Detailed information for compound 1274230

Basic information

Technical information
  • TDR Targets ID: 1274230
  • Name: N-[1-(4-methoxyphenyl)-6,6-dimethyl-5,7-dihyd ro-4H-indazol-4-yl]-2-methylpyrazole-3-carbox amide
  • MW: 379.456 | Formula: C21H25N5O2
  • H donors: 1 H acceptors: 3 LogP: 2.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1ncc2c1CC(C)(C)CC2NC(=O)c1ccnn1C
  • InChi: 1S/C21H25N5O2/c1-21(2)11-17(24-20(27)18-9-10-22-25(18)3)16-13-23-26(19(16)12-21)14-5-7-15(28-4)8-6-14/h5-10,13,17H,11-12H2,1-4H3,(H,24,27)
  • InChiKey: JEDMTKHBAOFZLM-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[1-(4-methoxyphenyl)-6,6-dimethyl-5,7-dihydro-4H-indazol-4-yl]-2-methyl-pyrazole-3-carboxamide
  • N-[1-(4-methoxyphenyl)-6,6-dimethyl-5,7-dihydro-4H-indazol-4-yl]-2-methyl-3-pyrazolecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei pantothenate kinase subunit, putative 0.0013 0.0011 0.008
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0034 0.0161 0.0206
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0011 0.0009
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0114 0.0738 0.1064
Brugia malayi cytochrome P450 0.0034 0.0161 0.0212
Schistosoma mansoni hypothetical protein 0.0035 0.0166 0.0166
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0024 0.0091 0.0127
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0074 0.045 0.0647
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.1276 0.1681
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0006
Echinococcus granulosus lamin dm0 0.0027 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0141
Trichomonas vaginalis antibiotic synthetase, putative 0.0093 0.0585 0.7332
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0794 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0008
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0389 0.0389
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0073 0.0073
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0032 0.0137
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0701 0.0993
Plasmodium vivax importin-beta 2, putative 0.0029 0.013 0.1798
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0073 0.0096
Schistosoma mansoni intermediate filament proteins 0.0027 0.011 0.011
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.0794 1
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0794 1
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0032 0.0268
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0011 0.0014
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0975 0.6924 1
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0013 0.0011 0.0009
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0093 0.0585 0.7332
Schistosoma mansoni acetyl-CoA synthetase 0.0093 0.0585 0.0585
Onchocerca volvulus 0.0093 0.0585 0.3755
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0259
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.0032 0.0039
Plasmodium falciparum DNase I-like protein, putative 0.0016 0.0032 0.047
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0701 0.1009
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0076 0.0467 0.0671
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0073 0.0407
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0988 0.7016 1
Brugia malayi Importin beta-1 subunit 0.0029 0.013 0.0171
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0034 0.0161 0.0229
Loa Loa (eye worm) hypothetical protein 0.0029 0.013 0.0171
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0279 0.3479
Leishmania major acetyl-CoA synthetase, putative 0.0093 0.0585 0.0839
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Brugia malayi intermediate filament protein 0.0027 0.011 0.0145
Giardia lamblia Long chain fatty acid CoA ligase, putative 0.0013 0.0011 0.0133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1276 0.1276
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.0481 0.068
Giardia lamblia Hypothetical protein 0.0013 0.0011 0.0133
Mycobacterium ulcerans polyketide synthase 0.0076 0.0467 0.061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0701 0.0701
Loa Loa (eye worm) hypothetical protein 0.0121 0.0786 0.1036
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0155 0.2184
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0096
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0101 0.0641 0.0839
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0013 0.0011 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0073 0.0073
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0031 0.014 0.0199
Onchocerca volvulus 0.0016 0.0032 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1276 0.1276
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0032 0.0042
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0701 0.8805
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0073 0.0073
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0585 0.0842
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0155 0.2159
Loa Loa (eye worm) hypothetical protein 0.05 0.3509 0.4622
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.0585 0.0765
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0032 0.0032
Brugia malayi Cytochrome P450 family protein 0.0034 0.0161 0.0212
Loa Loa (eye worm) hypothetical protein 0.0093 0.0585 0.0771
Mycobacterium ulcerans polyketide synthase Pks13 0.0114 0.0738 0.0968
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0794 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.0501 0.0655
Echinococcus multilocularis 6 phosphofructokinase 0.0122 0.0794 0.0794
Schistosoma mansoni hypothetical protein 0.0102 0.065 0.065
Loa Loa (eye worm) hypothetical protein 0.0178 0.1197 0.1577
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0196 0.0259
Schistosoma mansoni ets-related 0.0222 0.1511 0.1511
Schistosoma mansoni DNA polymerase eta 0.0039 0.0196 0.0196
Brugia malayi AMP-binding enzyme family protein 0.1068 0.7591 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0155 0.2589
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0196 0.243
Echinococcus multilocularis muscleblind protein 0.032 0.2215 0.2215
Leishmania major long chain fatty Acyl CoA synthetase, putative 0.0013 0.0011 0.0009
Schistosoma mansoni ap endonuclease 0.0078 0.0481 0.0481
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0013 0.0011 0.0008
Entamoeba histolytica acyl-coA synthetase, putative 0.0093 0.0585 0.7332
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0975 0.6924 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0155 0.2184
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0268
Brugia malayi hypothetical protein 0.005 0.0275 0.0362
Brugia malayi N-terminal motif family protein 0.0178 0.1197 0.1577
Brugia malayi beta-lactamase family protein 0.0109 0.0701 0.0923
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0032 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0155 0.1838
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0701 0.0923
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0013 0.0011 0.0009
Leishmania major fatty acyl CoA syntetase 1, putative 0.0013 0.0011 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0032
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.0794 0.1046
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 4 0.0013 0.0011 0.0011
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0019 0.0056 0.0074
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0034 0.0161 0.0229
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0279 0.0397
Echinococcus granulosus AMP dependent ligase 0.0021 0.0066 0.0066
Mycobacterium ulcerans hypothetical protein 0.0109 0.0701 0.0918
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0155 0.1838
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0032 0.0392
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0471 0.0665
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0585 0.0842
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0074 0.0074
Onchocerca volvulus Fatty acid synthase homolog 0.0138 0.0908 0.5862
Plasmodium vivax acetyl-CoA synthetase, putative 0.0093 0.0585 0.8342
Echinococcus granulosus tar DNA binding protein 0.0076 0.0468 0.0468
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0073 0.0073
Trichomonas vaginalis antibiotic synthetase, putative 0.0093 0.0585 0.7332
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.0794 0.1046
Brugia malayi 6-phosphofructokinase 0.0122 0.0794 0.1046
Schistosoma mansoni FFA transport protein 0.0988 0.7016 0.7016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0073 0.0073
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0032 0.0346
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0155 0.1838
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0032 0.0032
Brugia malayi Fli-1 protein 0.0222 0.1511 0.199
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0093 0.0585 0.0585
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0468 0.0468
Echinococcus granulosus disco interacting protein 2 0.0013 0.0011 0.0011
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0279 0.0392
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0013 0.0011 0.0009
Loa Loa (eye worm) phosphofructokinase 0.0122 0.0794 0.1046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1276 0.1276
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0196 0.0277
Echinococcus granulosus cpg binding protein 0.003 0.0134 0.0134
Plasmodium falciparum importin beta, putative 0.0029 0.013 0.2155
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0073 0.0073
Onchocerca volvulus 0.0109 0.0701 0.4509
Echinococcus granulosus acyl coenzyme A synthetase family 0.0013 0.0011 0.0011
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0093 0.0585 0.0771
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0196 0.243
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0034 0.0161 0.0206
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 0.0013 0.0011 0.0011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.0481 0.0481
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0279 0.0279
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0032 0.0032
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0034 0.0161 0.0229
Brugia malayi beta-lactamase 0.0109 0.0701 0.0923
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0701 0.0701
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0032 0.0042
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0701 0.8805
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.0481 0.0634
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0.0107 0.0151
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0196 0.243
Leishmania major hypothetical protein, conserved 0.0016 0.0032 0.0039
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0034 0.0161 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0034 0.0161 0.0229
Mycobacterium tuberculosis Probable fatty acyl-AMP ligase MbtM 0.0013 0.0011 0.0012
Leishmania major hypothetical protein, conserved 0.0016 0.0032 0.0039
Giardia lamblia Long chain fatty acid CoA ligase 4 0.0013 0.0011 0.0133
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0096
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0279 0.0279
Mycobacterium leprae POSSIBLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE) 0.0013 0.0011 0.0012
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0032 0.0346
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0073 0.0073
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0794 1
Brugia malayi phosphofructokinase 0.0122 0.0794 0.1046
Mycobacterium tuberculosis Hypothetical protein 0.0023 0.0083 0.0117
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0042
Schistosoma mansoni cytochrome P450 0.0034 0.0161 0.0161
Trypanosoma brucei fatty acyl CoA synthetase, putative 0.0013 0.0011 0.008
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0073 0.0073
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0101 0.0641 0.0922
Trypanosoma cruzi AMP-binding enzyme, putative 0.0013 0.0011 0.0009
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0013 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.0034 0.0161 0.0161
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0101 0.0641 0.0922
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0155 1
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0481 0.6006
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0093 0.0585 0.8347
Loa Loa (eye worm) hypothetical protein 0.0043 0.0226 0.0297
Echinococcus multilocularis snurportin 1 0.0314 0.2176 0.2176
Schistosoma mansoni hypothetical protein 0.0112 0.0722 0.0722
Schistosoma mansoni synaptojanin 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Echinococcus granulosus cytochrome P450 2K1 0.0034 0.0161 0.0161
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0145 0.0959 0.1263
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0034 0.0161 0.0229
Echinococcus multilocularis AMP dependent ligase 0.0021 0.0066 0.0066
Leishmania major importin beta-1 subunit, putative 0.0024 0.009 0.0123
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.1276 0.1681
Plasmodium vivax long-chain-fatty-acid--CoA ligase, putative 0.0013 0.0011 0.0091
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0032 0.0032
Schistosoma mansoni AMP dependent ligase 0.0013 0.0011 0.0011
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0389 0.0389
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0034 0.0161 0.0223
Onchocerca volvulus 0.0105 0.0672 0.4324
Trypanosoma brucei Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5), putative 0.0013 0.0011 0.008
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0011 0.008
Echinococcus granulosus synaptojanin 1 0.0016 0.0032 0.0032
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0357 0.0471
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0042
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0034 0.0161 0.0206
Schistosoma mansoni coup transcription factor 0.0022 0.0073 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.0585 0.0765
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 0.0013 0.0011 0.0008
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.0794 0.0794
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0423
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Brugia malayi CXXC zinc finger family protein 0.0028 0.0123 0.0162
Schistosoma mansoni hypothetical protein 0.0314 0.2176 0.2176
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0073 0.0096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1276 0.1276
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0019 0.0056 0.0885
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0032 0.0032
Entamoeba histolytica acyl-CoA synthetase, putative 0.0093 0.0585 0.7332
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.0481 0.0629
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0794 1
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0021 0.0066 0.0081
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0004 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0196 0.243
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0021 0.0028
Mycobacterium tuberculosis Conserved protein 0.0109 0.0701 0.1009
Trichomonas vaginalis importin beta-1, putative 0.0024 0.009 0.1006
Brugia malayi hypothetical protein 0.0077 0.0471 0.062
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0011 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0357 0.0471
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0093 0.0585 0.0842
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0032 0.0268
Onchocerca volvulus Huntingtin homolog 0.0121 0.0786 0.5069
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0061 0.036 0.0516
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0093 0.0585 0.0828
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0794 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.0585 0.0765
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Schistosoma mansoni cpg binding protein 0.003 0.0134 0.0134
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0074 0.0097
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0093 0.0585 0.0842
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0034 0.0161 0.0206
Mycobacterium ulcerans acyl-CoA synthetase 0.0101 0.0641 0.0839
Loa Loa (eye worm) hypothetical protein 0.0354 0.246 0.3241
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0008
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0013 0.0011 0.0133
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0468 0.0616
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0034 0.0161 0.0229
Schistosoma mansoni hypothetical protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0096
Trypanosoma brucei acetyl-CoA synthetase, truncated 0.0013 0.0011 0.008
Leishmania major fatty acyl CoA synthetase 2, putative 0.0013 0.0011 0.0009
Schistosoma mansoni cpg binding protein 0.003 0.0134 0.0134
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 0.0013 0.0011 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0093 0.0585 0.0771
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.0481 0.0689
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0034 0.0161 0.0206
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0093 0.0585 0.0842
Brugia malayi TAR-binding protein 0.0076 0.0468 0.0616
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0027 0.011 0.065
Loa Loa (eye worm) fatty acid synthase 0.0075 0.046 0.0606
Trichomonas vaginalis ran, putative 0.0022 0.0074 0.0804
Schistosoma mansoni hypothetical protein 0.0242 0.1656 0.1656
Mycobacterium ulcerans beta-lactamase 0.0109 0.0701 0.0918
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0196 0.243
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0196 0.243
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.083 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0073 0.0096
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0093 0.0585 0.0842
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0279 0.3426
Loa Loa (eye worm) RNA binding protein 0.0076 0.0468 0.0616
Schistosoma mansoni hypothetical protein 0.0112 0.0722 0.0722
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0423
Onchocerca volvulus Huntingtin homolog 0.0121 0.0786 0.5069
Leishmania major DNA polymerase kappa, putative 0.0039 0.0196 0.0277
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0423
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0155 0.1838
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0443 0.0583
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0013 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0073 0.0096
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0073 0.0073
Echinococcus multilocularis microtubule associated protein 2 0.1368 0.975 0.975
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0032 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.0061 0.0357 0.0503
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0011 0.0012
Brugia malayi MAP kinase sur-1 0.005 0.0279 0.0368
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0013 0.0011 0.0133
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0093 0.0585 0.7353
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0155 0.1838
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0032 0.0039
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0468 0.0468
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0155 0.1838
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0016 0.0032 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.011 0.1337
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0196 0.243
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0013 0.0011 0.0009
Loa Loa (eye worm) oxidoreductase 0.0093 0.0585 0.0771
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0122 0.0794 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0279 0.0392
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0073 0.0073
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0074 0.1193
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0032 0.0042
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0013 0.0011 0.0008
Onchocerca volvulus 0.0109 0.0701 0.4509
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0011 0.0008
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0268
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0073 0.0073
Trichomonas vaginalis esterase, putative 0.0109 0.0701 0.8805
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.0501 0.0721
Brugia malayi Cytochrome P450 family protein 0.0061 0.0357 0.0471
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0013 0.0011 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0196 0.0259
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0352 0.0352
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0196 0.028
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0279 0.0397
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0468 0.0616
Giardia lamblia Methyltransferase like 2 0.0023 0.0083 0.1656
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1276 0.1276
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0196 0.0196
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0279 0.0392
Schistosoma mansoni hypothetical protein 0.0406 0.2832 0.2832
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.0032 0.0039
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0032 0.0032
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0032 0.0042
Loa Loa (eye worm) hypothetical protein 0.0112 0.0722 0.0952
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0032 0.0042
Leishmania major ATP-dependent phosphofructokinase 0.0122 0.0794 0.1141
Toxoplasma gondii hypothetical protein 0.0013 0.0011 0.0122
Brugia malayi Disco-interacting protein 2 homolog 0.0013 0.0011 0.0014
Echinococcus granulosus long chain fatty acid transport protein 4 0.0988 0.7016 0.7016
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0062 0.0367 0.0527
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0101 0.0641 0.0839
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0032 0.0042
Leishmania major DNA polymerase eta, putative 0.0039 0.0196 0.0277
Plasmodium vivax ATP-dependent acyl-CoA synthetase, putative 0.0013 0.0011 0.0091
Giardia lamblia DINP protein human, muc B family 0.0039 0.0196 0.4025
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0034 0.0161 0.0229
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0279 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.011 0.1337
Onchocerca volvulus 0.0093 0.0585 0.3755
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0161 0.0223
Echinococcus multilocularis synaptojanin 1 0.0016 0.0032 0.0032
Trypanosoma brucei fatty acyl CoA synthetase 2 0.0013 0.0011 0.008
Brugia malayi steroid hormone receptor 0.0022 0.0073 0.0096
Trypanosoma cruzi fatty acyl CoA synthetase, putative 0.0013 0.0011 0.0009
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0268
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0112 0.0722 0.0722
Schistosoma mansoni ap endonuclease 0.0078 0.0481 0.0481
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0032 0.0042
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.0481 0.6006
Brugia malayi Muscleblind-like protein 0.032 0.2215 0.2919
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.011 0.0145
Brugia malayi RNA binding protein 0.0076 0.0468 0.0616
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0032 0.0346
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0034 0.0161 0.0206
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0701 0.8805
Echinococcus granulosus dna polymerase eta 0.0039 0.0196 0.0196
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0032 0.0268
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.013 0.1584
Onchocerca volvulus 0.0109 0.0701 0.4509
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0196 0.0259
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0032 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0011 0.0008
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.0794 0.0794
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0032 0.0268
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0093 0.0585 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0073 0.0096
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0011 0.0122
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0076 0.0467 0.0671
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0073 0.0073
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0034 0.0161 0.0226
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0467 0.061
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0073 0.0407
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0122 0.0794 0.1144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0101 0.0641 0.0844
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0034 0.0161 0.0229
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.1197 0.7757
Echinococcus multilocularis survival motor neuron protein 1 0.05 0.3509 0.3509
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0034 0.0161 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0468 0.0468
Echinococcus granulosus snurportin 1 0.0314 0.2176 0.2176
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0074 0.1453
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.0481 0.0692
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0101 0.0641 0.0839
Loa Loa (eye worm) latrophilin receptor protein 2 0.0112 0.0722 0.0952
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0019 0.0056 0.0651
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0019 0.0056 0.0073
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 0.0013 0.0011 0.0011
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0467 0.061
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.011 0.1337
Echinococcus granulosus microtubule associated protein 2 0.1368 0.975 0.975
Echinococcus multilocularis importin subunit beta 1 0.0029 0.013 0.013
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0196 0.243
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0701 0.0918
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0093 0.0585 0.0828
Echinococcus granulosus dnaJ subfamily B 0.0406 0.2832 0.2832
Loa Loa (eye worm) hypothetical protein 0.0093 0.0585 0.0771
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0073 0.0096
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0166 0.0166
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0093 0.0585 0.0771
Toxoplasma gondii ABC1 family protein 0.0109 0.0701 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0268
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0013 0.0011 0.0009
Leishmania major fatty acid transporter protein-like protein 0.0975 0.6924 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0034 0.0161 0.0206
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Echinococcus multilocularis dna polymerase eta 0.0039 0.0196 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0073 0.0096
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0471 0.671
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 0.0013 0.0011 0.0011
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0032 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1276 0.1276
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0019 0.0056 0.0074
Brugia malayi CCR4 0.0016 0.0032 0.0042
Schistosoma mansoni amine GPCR 0.0329 0.2281 0.2281
Mycobacterium tuberculosis Putative polyketide synthase Pks16 0.0013 0.0011 0.0012
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0032 0.047
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.083 0.1094
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.001
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0122 0.0794 0.1144
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0196 0.243
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0306 0.4345
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0034 0.0161 0.0206
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Loa Loa (eye worm) cytochrome P450 0.0034 0.0161 0.0212
Leishmania major acetyl-CoA synthetase, putative 0.0093 0.0585 0.0839
Mycobacterium ulcerans thioesterase TesA 0.0064 0.0376 0.0489
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0279 0.0279
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0034 0.0161 0.0229
Trypanosoma brucei fatty acyl CoA synthetase, putative 0.0013 0.0011 0.008
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0073 0.0096
Mycobacterium ulcerans hypothetical protein 0.0093 0.0585 0.0765
Echinococcus multilocularis GPCR, family 2 0.0112 0.0722 0.0722
Brugia malayi AMP-binding enzyme family protein 0.0093 0.0585 0.0771
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1276 0.1276
Mycobacterium ulcerans polyketide synthase MbtC 0.0019 0.0056 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0073 0.0073
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0032 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0279 0.3426
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0019 0.0056 0.0056
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0109 0.0701 0.0923
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0021 0.0028
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0011 0.0009
Leishmania major hypothetical protein, conserved 0.0013 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0093 0.0585 0.0765
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0011
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0011 0.0122
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0701 0.8814
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0032 0.0032
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0011 0.0012
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0196 0.0196
Leishmania major long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative 0.0013 0.0011 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0093 0.0585 0.0839
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0011 0.0014
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0073 0.0073
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0013 0.0011 0.0008
Echinococcus granulosus muscleblind protein 0.032 0.2215 0.2215
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0279 0.0368
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0013 0.0011 0.0012
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0423
Brugia malayi Calcitonin receptor-like protein seb-1 0.0354 0.246 0.3241
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0701 0.0993
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0034 0.0161 0.0206
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.0585 0.0765
Schistosoma mansoni microtubule-associated protein tau 0.1368 0.975 0.975
Leishmania major hypothetical protein, conserved 0.0077 0.0471 0.0674
Trypanosoma cruzi cytochrome P450, putative 0.0061 0.0357 0.0503
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0794 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0279 0.3426
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0073 0.0096
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0076 0.0467 0.0671
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0074 0.0877
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0073 0.0096
Echinococcus granulosus lamin 0.0027 0.011 0.011
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0453 0.0597
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0196 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0073 0.0096
Leishmania major hypothetical protein, conserved 0.0109 0.0701 0.1006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0354 0.246 0.3241
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0032 0.0039
Schistosoma mansoni lamin 0.0027 0.011 0.011
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0196 0.2369
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0011 0.0122
Echinococcus multilocularis acyl coenzyme A synthetase family 0.0013 0.0011 0.0011
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0019 0.0056 0.0056
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0279 0.0392
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0032 0.0268
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0034 0.0161 0.0229
Loa Loa (eye worm) fli-1 protein 0.0222 0.1511 0.199
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0196 0.028
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0032 0.0042
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0585 0.0842
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0032 0.0346
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0096
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0093 0.0585 0.7353
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0093 0.0585 0.0842
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0051 0.0281 0.0365
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0034 0.0161 0.0229
Onchocerca volvulus 0.0164 0.1098 0.7107
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0101 0.0641 0.0922
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.0585 0.0765
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0032 0.0039
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.065 0.0857
Brugia malayi AMP-binding enzyme family protein 0.0093 0.0585 0.0771
Brugia malayi Ets-domain containing protein 0.0073 0.0443 0.0583
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0389 0.0508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0073 0.0096
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0093 0.0585 0.0839
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0074 0.1023
Mycobacterium tuberculosis Conserved protein 0.0109 0.0701 0.1009
Trypanosoma cruzi fatty acyl CoA synthetase, putative 0.0013 0.0011 0.0009
Brugia malayi Ets-domain containing protein 0.0073 0.0443 0.0583
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0076 0.0467 0.0615
Plasmodium vivax acyl-CoA synthetase, putative 0.0013 0.0011 0.0091
Onchocerca volvulus 0.0016 0.0032 0.0137
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Leishmania major hypothetical protein, conserved 0.0023 0.0083 0.0114
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.1068 0.7591 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.013 0.013
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0196 0.0253
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0032 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.0585 0.0765
Loa Loa (eye worm) AMP-binding enzyme family protein 0.1068 0.7591 1
Mycobacterium ulcerans lipase LipD 0.0109 0.0701 0.0918
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0423
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0701 0.1009
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0279 0.0279
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0164 0.1098 0.1583
Plasmodium vivax exodeoxyribonuclease III, putative 0.0016 0.0032 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0073 0.0096
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0073 0.0073
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0471 0.5905
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0112 0.0722 0.0722
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 0.0013 0.0011 0.0011
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0443 0.0443
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0073 0.0073
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0032 0.0039
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0423
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0034 0.0161 0.0206
Trypanosoma brucei fatty acyl CoA synthetase 4 0.0013 0.0011 0.008
Mycobacterium tuberculosis Probable thioesterase TesA 0.0064 0.0376 0.0539
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0093 0.0585 0.0828
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0013 0.0011 0.0012
Echinococcus granulosus intermediate filament protein 0.0027 0.011 0.011
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0155 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0078 0.0481 0.6006
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0032 0.0042
Echinococcus multilocularis muscleblind protein 1 0.032 0.2215 0.2215
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0034 0.0161 0.0206
Schistosoma mansoni lamin 0.0027 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0701 0.0923
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.0481 0.068
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0093 0.0585 0.0828
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 0.0013 0.0011 0.0011
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0161 0.0223
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0066 0.0092
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0019 0.0052 0.0072
Brugia malayi Latrophilin receptor protein 2 0.0112 0.0722 0.0952
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0051 0.0281 0.0403
Loa Loa (eye worm) hypothetical protein 0.0093 0.0585 0.0771
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0196 0.0274
Loa Loa (eye worm) hypothetical protein 0.0077 0.0471 0.062
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0155 0.1838
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0112 0.0722 0.0952
Plasmodium vivax long-chain fatty acid CoA ligase, putative 0.0013 0.0011 0.0091
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0481 0.6006
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0008
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0093 0.0585 0.0771
Brugia malayi hypothetical protein 0.0013 0.0011 0.0014
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0101 0.0641 0.0922
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0279 0.3426
Schistosoma mansoni hypothetical protein 0.0112 0.0722 0.0722
Onchocerca volvulus 0.0028 0.0123 0.0731
Echinococcus granulosus survival motor neuron protein 1 0.05 0.3509 0.3509
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0034 0.0161 0.0229
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0109 0.0701 0.0923
Trypanosoma brucei fatty acyl CoA syntetase 1 0.0013 0.0011 0.008
Leishmania major hypothetical protein, unknown function 0.0013 0.0011 0.0009
Leishmania major hypothetical protein, conserved 0.0016 0.0032 0.0039
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0101 0.0641 0.0839
Brugia malayi RNA, U transporter 1 0.0084 0.052 0.0684
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0034 0.0161 0.0229
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0389 0.0556
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0354 0.246 0.3241
Trypanosoma brucei fatty acyl CoA synthetase 3 0.0013 0.0011 0.008
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0011 0.0122
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0093 0.0585 0.0765
Giardia lamblia hypothetical protein 0.0016 0.0032 0.0573
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0029 0.0345
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0013 0.0011 0.0009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0696 0.4917 0.7101
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0073 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0066 0.0092
Loa Loa (eye worm) beta-lactamase 0.0109 0.0701 0.0923
Entamoeba histolytica hypothetical protein 0.0024 0.009 0.1006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0073 0.0073
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0701 0.1009
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0155 0.2589
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0004 0.0031
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0096
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0019 0.0056 0.0073
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0015 0.0029 0.0414
Leishmania major 4-coumarate:coa ligase-like protein 0.0093 0.0585 0.0839
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 0.0013 0.0011 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0701 0.8805
Leishmania major GTP-binding protein, putative 0.0022 0.0074 0.01
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0034 0.0161 0.0229
Echinococcus granulosus dna polymerase kappa 0.0039 0.0196 0.0196
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0701 0.1009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0032 0.0039
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.0501 0.0655
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0389 0.0513
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0013 0.0011 0.0133
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0155 0.3152
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0389 0.0559
Schistosoma mansoni hypothetical protein 0.1403 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0471 0.8031
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0074 0.0099
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0013 0.0011 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0073 0.0096
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0011 0.0012
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0093 0.0585 0.0842
Echinococcus multilocularis geminin 0.1403 1 1
Onchocerca volvulus 0.0102 0.065 0.4181
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0011 0.0014
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0073 0.0073
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0196 0.0196
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0019 0.0056 0.0068
Mycobacterium leprae Putative polyketide synthetase Pks16 0.0013 0.0011 0.0012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0073 0.0073
Leishmania major 4-coumarate:coa ligase-like protein 0.0093 0.0585 0.0839
Echinococcus multilocularis musashi 0.0027 0.011 0.011
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.0585 0.0765
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0074 0.0995
Trypanosoma brucei unspecified product 0.0039 0.0196 0.243
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.001
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0019 0.0056 0.0767
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0701 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0701 0.0701
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0011 0.0009
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0081 0.0501 0.0721
Mycobacterium ulcerans polyketide synthase Pks9 0.0051 0.0281 0.0365
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0019 0.0056 0.0056
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0112 0.0722 0.0722
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0196 0.0274
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0155 0.2184
Brugia malayi cDNA sequence BC018371 0.0013 0.0011 0.0014
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0004 0.0004
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0073 0.0073
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0034 0.0161 0.0206
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0988 0.7016 0.7016
Loa Loa (eye worm) hypothetical protein 0.032 0.2215 0.2919
Echinococcus granulosus 6 phosphofructokinase 0.0122 0.0794 0.0794
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0701 0.1009
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0013 0.0011 0.0012
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.0481 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.009 0.1006
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0011 0.0008
Toxoplasma gondii propionate-CoA ligase 0.0093 0.0585 0.8347
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0093 0.0585 0.8347
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0073 0.0096
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0032 0.0039
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0032 0.0042
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Brugia malayi AMP-binding enzyme family protein 0.0093 0.0585 0.0771
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0081 0.0501 0.0721
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.2176 0.2867
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0032 0.0032
Brugia malayi MH2 domain containing protein 0.0127 0.083 0.1094
Loa Loa (eye worm) hypothetical protein 0.0242 0.1656 0.2182
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0073 0.0073
Brugia malayi hypothetical protein 0.0121 0.0786 0.1036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0073 0.0096
Brugia malayi AMP-binding enzyme family protein 0.0164 0.1098 0.1447
Mycobacterium leprae Polyketide synthase Pks13 0.0114 0.0738 0.1064
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0043 0.023 0.0329
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0032 0.0042
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0268
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0701 0.1009
Loa Loa (eye worm) intermediate filament protein 0.0027 0.011 0.0145
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0034 0.0161 0.0206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0011 0.0012
Trypanosoma brucei cytochrome P450, putative 0.0061 0.0357 0.4469
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0471 0.0665
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0155 0.1838
Loa Loa (eye worm) hypothetical protein 0.0141 0.0933 0.1229
Echinococcus multilocularis lamin 0.0027 0.011 0.011
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0032 0.0032
Onchocerca volvulus 0.0027 0.011 0.065
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0492 0.0708
Brugia malayi Cytochrome P450 family protein 0.0061 0.0357 0.0471
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0093 0.0585 0.0765
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0011 0.0012
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 0.0013 0.0011 0.0008
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.0481 0.6038
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0052 0.0288 0.4095
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0034 0.0161 0.0229
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0093 0.0585 0.0765
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0011 0.0008
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0196 0.2369
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0093 0.0585 0.0765
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0032 0.0268
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0073 0.0073
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0032 0.0039
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0081 0.0501 0.0721
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.0467 0.0671
Schistosoma mansoni ran 0.0022 0.0074 0.0074
Mycobacterium leprae Probable polyketide synthase Pks1 0.0081 0.0501 0.0721
Schistosoma mansoni cript-related 0.0016 0.0032 0.0032
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0034 0.0161 0.1977
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0093 0.0585 0.0842
Trypanosoma brucei acyl-CoA synthetase, putative 0.0013 0.0011 0.008
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0073 0.0073
Onchocerca volvulus 0.0226 0.1541 1
Toxoplasma gondii exonuclease III APE 0.0078 0.0481 0.686
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0268
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0471 0.67
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0196 0.0274
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0032 0.0268
Loa Loa (eye worm) hypothetical protein 0.0027 0.0115 0.0151
Mycobacterium tuberculosis Probable exported protein 0.0016 0.0032 0.0043
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0032 0.0039
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0112 0.0722 0.0722
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0011 0.0012
Brugia malayi nuclear receptor NHR-88 0.0022 0.0073 0.0096
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0019 0.0056 0.0074
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0389 0.0508
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0027 0.011 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0196 0.243
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0013 0.0011 0.0009
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0073 0.0096
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0032 0.0042
Loa Loa (eye worm) hypothetical protein 0.0109 0.0701 0.0923
Schistosoma mansoni gabp alpha 0.0073 0.0443 0.0443
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0074 0.0097
Loa Loa (eye worm) hypothetical protein 0.0062 0.0367 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0196 0.243
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.013 0.1823
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0011 0.0012
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0032 0.0042
Schistosoma mansoni nocturnin 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.032 0.2215 0.2919
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0196 0.0196
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0032 0.0268
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0155 0.2159
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0155 0.1838
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0096
Giardia lamblia Inositol 5-phosphatase 4 0.0016 0.0032 0.0573
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0021 0.0066 0.0081
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.009 0.1006
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0164 0.1098 0.1447
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0196 0.243
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0011 0.0012
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0061 0.036 0.0468
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0083 0.0927
Trypanosoma brucei unspecified product 0.0027 0.011 0.1337
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0389 0.0389
Loa Loa (eye worm) CYP4Cod1 0.0061 0.0357 0.0471
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0013 0.0011 0.0133
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0701 0.1009
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.005 0.0274 0.3894
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.013 0.1584
Trypanosoma brucei protein kinase, putative 0.005 0.0279 0.3479
Schistosoma mansoni synaptojanin 0.0016 0.0032 0.0032
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0093 0.0585 0.0765
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0032 0.0268
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD11 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0011 0.0012
Mycobacterium ulcerans thioesterase 0.0064 0.0376 0.0489
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0032 0.0346
Brugia malayi hypothetical protein 0.05 0.3509 0.4622
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0468 0.0468
Brugia malayi latrophilin 2 splice variant baaae 0.0242 0.1656 0.2182
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0073 0.0096
Echinococcus multilocularis disco interacting protein 2 0.0013 0.0011 0.0011
Mycobacterium ulcerans fatty acid synthase Fas 0.0024 0.0091 0.0113
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0032 0.0039
Schistosoma mansoni hypothetical protein 0.0112 0.0722 0.0722
Brugia malayi AMP-binding enzyme family protein 0.0036 0.018 0.0237
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0011 0.0014
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.0794 0.1126
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0988 0.7016 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0585 0.0842
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0481 0.685
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0701 0.8805
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0701 0.0923
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.0585 0.0765
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0034 0.0161 0.0206
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0032 0.0032
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0701 0.0701
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0032 0.0392
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 0.0013 0.0011 0.0011
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0034 0.0161 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0468 0.0468
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0032 0.0042
Echinococcus multilocularis 0.0034 0.0161 0.0161
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0196 0.243
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.0585 0.0765
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0081 0.0501 0.0721
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0032 0.047
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0034 0.0161 0.0229
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0196 0.0253
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0279 0.5761
Echinococcus multilocularis cpg binding protein 0.003 0.0134 0.0134
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Entamoeba histolytica acyl-CoA synthetase, putative 0.0101 0.0641 0.8039
Mycobacterium tuberculosis Conserved protein 0.0109 0.0701 0.1009
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0011 0.0109
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0004 0.0031
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0029 0.0125 0.0171
Schistosoma mansoni survival motor neuron protein 0.0102 0.065 0.065
Mycobacterium leprae Probable lipase LipE 0.0109 0.0701 0.1009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0467 0.061
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0013 0.0011 0.0008
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0061 0.0357 0.0465
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0032 0.0392
Brugia malayi beta-lactamase family protein 0.0109 0.0701 0.0923
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0032 0.0032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0073 0.0096
Schistosoma mansoni ran 0.0022 0.0074 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0471 0.8031
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 0.0013 0.0011 0.0011
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0034 0.0161 0.0206
Toxoplasma gondii cytochrome p450 superfamily protein 0.0034 0.0161 0.2267
Mycobacterium leprae putative cytochrome p450 0.0034 0.0161 0.0229
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0019 0.0056 0.0738
Echinococcus granulosus GPCR family 2 0.0112 0.0722 0.0722
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0073 0.0073
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0701 0.0918
Brugia malayi ecdysteroid receptor 0.0022 0.0073 0.0096
Loa Loa (eye worm) hypothetical protein 0.0109 0.0701 0.0923
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0032 0.0042
Toxoplasma gondii type I fatty acid synthase, putative 0.0094 0.0594 0.8471
Mycobacterium leprae Conserved hypothetical protein 0.0034 0.0161 0.0229
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0032 0.0268
Mycobacterium ulcerans 6-phosphofructokinase 0.0122 0.0794 0.1041
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.0481 1
Brugia malayi Cytochrome P450 family protein 0.0074 0.0453 0.0597
Leishmania major cytochrome p450-like protein 0.0034 0.0161 0.0226
Schistosoma mansoni importin beta-1 0.0029 0.013 0.013
Brugia malayi follicle stimulating hormone receptor 0.0235 0.1609 0.212
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0034 0.0161 0.0229
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0279 0.3965
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0114 0.0738 0.1064
Brugia malayi polk-prov protein 0.0012 0.0004 0.0006
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0032 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0073 0.0096
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0032 0.0268
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.2832 0.2832
Brugia malayi 6-phosphofructokinase 0.0122 0.0794 0.1046
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.1609 0.212
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.009 0.0121
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0076 0.0467 0.0671
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0016 0.0032 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0196 0.243
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0011 0.0091
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0032 0.0346
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0032 0.0423
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0196 0.0274
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0013 0.0011 0.0011
Brugia malayi hypothetical protein 0.0013 0.0011 0.0014
Schistosoma mansoni hypothetical protein 0.1403 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0073 0.0073
Schistosoma mansoni cpg binding protein 0.0028 0.0123 0.0123
Mycobacterium ulcerans acetyl-CoA synthetase 0.0093 0.0585 0.0765
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0074 0.0099
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.0481 0.0634
Brugia malayi AMP-binding enzyme family protein 0.0093 0.0585 0.0771
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0701 0.0923
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0061 0.036 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0073 0.0096
Loa Loa (eye worm) acyl carrier protein 0.0035 0.0171 0.0225
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0032 0.0268
Onchocerca volvulus 0.0022 0.0073 0.0407
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.0032 0.0039
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 0.0013 0.0011 0.0008
Trypanosoma brucei unspecified product 0.0027 0.011 0.1337
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0011 0.0011
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0073 0.0407
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0011 0.0109
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0358 0.0471
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0032 0.0032
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0019 0.0056 0.313
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0101 0.0641 0.0922
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.0585 0.0765
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0019 0.0056 0.0068
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.0032 0.0039
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0034 0.0161 0.0206
Leishmania major pantothenate kinase subunit, putative 0.0029 0.0125 0.0173
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0032 0.0268
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0074 0.045 0.0647
Mycobacterium ulcerans polyketide synthase 0.0081 0.0501 0.0655
Mycobacterium tuberculosis Conserved protein 0.0023 0.0083 0.0117
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0013 0.0011 0.0008
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0093 0.0585 0.0585
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0093 0.0585 0.0765
Treponema pallidum hypothetical protein 0.0016 0.0032 0.0268
Brugia malayi nuclear hormone receptor 0.0022 0.0073 0.0096
Schistosoma mansoni methyltransferase-related 0.0023 0.0083 0.0083
Echinococcus multilocularis lamin dm0 0.0027 0.011 0.011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0701 0.1009
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0011 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0073 0.0096
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0468 0.0616
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0828 0.5866 0.5866
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0123 0.0162
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0096
Entamoeba histolytica Ran family GTPase 0.0022 0.0074 0.0804
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0064 0.0376 0.0539
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0032 0.0346
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0034 0.0161 0.0229
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0196 0.2369
Leishmania major cytochrome p450-like protein 0.0034 0.0161 0.0226
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0011 0.0009
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0166 0.0166
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.0467 0.061
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.011 0.0145
Loa Loa (eye worm) hypothetical protein 0.0121 0.0786 0.1036
Toxoplasma gondii type I fatty acid synthase, putative 0.0054 0.0309 0.439
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0073 0.0096
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0032 0.0346
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0034 0.0161 0.0229
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0024 0.0091 0.0127
Leishmania major cytochrome p450-like protein 0.0061 0.0357 0.051
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0481 0.8211
Echinococcus granulosus long chain fatty acid coenzyme A ligase 4 0.0013 0.0011 0.0011
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0023 0.0087 0.0122
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0042
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0443 0.0443
Mycobacterium ulcerans polyketide synthase MbtD 0.0023 0.0087 0.0109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0585 0.0842
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0034 0.0161 0.0229
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0034 0.0161 0.0206
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0011 0.0014
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0066 0.0708
Brugia malayi Methyltransferase-like protein 4 0.0023 0.0083 0.011
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0055 0.0312 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0073 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0468 0.0468

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1683 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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