Detailed information for compound 1507177

Basic information

Technical information
  • TDR Targets ID: 1507177
  • Name: (4E)-4-[(1-acetylindol-3-yl)methylidene]-2-ph enyl-1,3-oxazol-5-one
  • MW: 330.337 | Formula: C20H14N2O3
  • H donors: 0 H acceptors: 2 LogP: 3.52 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC(=N/C/1=C/c1cn(c2c1cccc2)C(=O)C)c1ccccc1
  • InChi: 1S/C20H14N2O3/c1-13(23)22-12-15(16-9-5-6-10-18(16)22)11-17-20(24)25-19(21-17)14-7-3-2-4-8-14/h2-12H,1H3/b17-11+
  • InChiKey: SNVSWEBYYVWBGR-GZTJUZNOSA-N  


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Synonyms

  • 4-[(1-acetylindol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5-one
  • (4E)-4-[(1-acetylindol-3-yl)methylene]-2-phenyl-oxazol-5-one
  • 4-[(1-acetylindol-3-yl)methylene]-2-phenyl-oxazol-5-one
  • 4-[(1-acetyl-3-indolyl)methylene]-2-phenyl-5-oxazolone
  • (4E)-4-[(1-acetyl-3-indolyl)methylene]-2-phenyl-5-oxazolone
  • (4E)-4-[(1-ethanoylindol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5-one
  • 4-[(1-ethanoylindol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5-one
  • 77362-24-4
  • NSC202094
  • MLS000557203
  • SMR000174534
  • 4-(1-Acetyl-1H-indol-3-ylmethylene)-2-phenyl-4H-oxazol-5-one
  • BAS 00340590
  • PD 00564
  • ZINC00069763

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Carica papaya Papain Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis papain family cysteine protease containing protein Papain   345 aa 342 aa 31.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 361 aa 24.9 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Papain   345 aa 323 aa 26.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 318 aa 22.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 392 aa 23.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Plasmodium yoelii cysteine proteinase precursor Papain   345 aa 346 aa 30.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 302 aa 24.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus granulosus cathepsin b Papain   345 aa 321 aa 25.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Onchocerca volvulus Papain   345 aa 326 aa 31.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Plasmodium vivax unspecified product Papain   345 aa 358 aa 30.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Theileria parva cysteine proteinase, putative Papain   345 aa 350 aa 29.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 357 aa 26.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Theileria parva cysteine proteinase, putative Papain   345 aa 307 aa 29.0 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Papain   345 aa 324 aa 35.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Plasmodium vivax vivapain-3 Papain   345 aa 340 aa 33.2 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma cruzi cysteine proteinase, putative Papain   345 aa 299 aa 30.1 %
Plasmodium knowlesi knowpain-1 Papain   345 aa 396 aa 29.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Neospora caninum hypothetical protein Papain   345 aa 297 aa 23.2 %
Trypanosoma cruzi cysteine proteinase, putative Papain   345 aa 298 aa 29.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Papain   345 aa 328 aa 33.5 %
Giardia lamblia Dipeptidyl-peptidase I precursor Papain   345 aa 281 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma cruzi cysteine protease, putative Papain   345 aa 344 aa 30.8 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Papain   345 aa 328 aa 33.5 %
Giardia lamblia Dipeptidyl-peptidase I precursor Papain   345 aa 280 aa 29.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 Papain   345 aa 376 aa 30.6 %
Onchocerca volvulus Papain   345 aa 324 aa 32.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 343 aa 25.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Plasmodium vivax vivapain-1 Papain   345 aa 360 aa 30.0 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Brugia malayi cathepsin B-like cysteine proteinase Papain   345 aa 306 aa 26.1 %
Brugia malayi Papain family cysteine protease containing protein Papain   345 aa 308 aa 27.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 373 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Echinococcus multilocularis cathepsin L Papain   345 aa 355 aa 27.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Plasmodium berghei berghepain-1 Papain   345 aa 345 aa 29.9 %
Echinococcus granulosus cathepsin L Papain   345 aa 356 aa 36.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Onchocerca volvulus Papain   345 aa 307 aa 35.5 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 291 aa 24.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Papain   345 aa 342 aa 30.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Papain   345 aa 355 aa 30.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 321 aa 29.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis cathepsin L Papain   345 aa 352 aa 36.4 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Onchocerca volvulus Cathepsin L homolog Papain   345 aa 317 aa 33.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Onchocerca volvulus Protein MCM10 homolog Papain   345 aa 294 aa 34.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Echinococcus granulosus cathepsin L Papain   345 aa 316 aa 29.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Onchocerca volvulus Papain   345 aa 312 aa 35.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Papain   345 aa 313 aa 29.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Papain   345 aa 320 aa 28.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Onchocerca volvulus Papain   345 aa 344 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum cathepsin L-like proteinase Papain   345 aa 330 aa 37.3 %
Theileria parva cysteine proteinase, putative Papain   345 aa 324 aa 32.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.003 0.0009 0.0118
Toxoplasma gondii subtilisin SUB5 0.0406 0.0418 0.9653
Brugia malayi Protein kinase domain containing protein 0.0088 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Brugia malayi serpin 0.0023 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0044 0.0024 0.0024
Onchocerca volvulus 0.0118 0.0105 0.1575
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0406 0.0418 1
Trypanosoma brucei subtilisin peptidase 0.0406 0.0418 0.5881
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0033 0.0012 0.0011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0023 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Loa Loa (eye worm) subtilase 0.0406 0.0418 0.0418
Toxoplasma gondii F5/8 type C domain-containing protein 0.0033 0.0012 0.0253
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0037 0.0016 0.035
Trichomonas vaginalis hypothetical protein 0.0033 0.0012 0.0019
Plasmodium falciparum apical sushi protein 0.0037 0.0017 0.0372
Entamoeba histolytica cysteine protease, putative 0.0047 0.0027 0.0375
Loa Loa (eye worm) hypothetical protein 0.0071 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Entamoeba histolytica serine protease inhibitor, putative 0.0023 0.0001 0.0002
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.0883 0.0883
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0023 0.0037
Onchocerca volvulus Cathepsin F homolog 0.0047 0.0027 0.041
Brugia malayi pregnancy-associated plasma protein-A 0.0037 0.0017 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0023 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0033 0.0012 0.0262
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0021 0.0021
Leishmania major cathepsin L-like protease 0.0047 0.0027 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0071 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Brugia malayi BmSERPIN 0.0023 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0047 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Plasmodium falciparum subtilisin-like protease 3 0.0406 0.0418 0.986
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0011
Mycobacterium leprae Possible secreted protease 0.0406 0.0418 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Onchocerca volvulus Arrow homolog 0.0026 0.0005 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0023 0.0037
Echinococcus multilocularis discoidin domain containing receptor 2 0.0033 0.0012 0.0014
Onchocerca volvulus 0.0023 0.0001 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0027 0.0034
Brugia malayi hypothetical protein 0.0037 0.0017 0.0016
Onchocerca volvulus 0.0047 0.0027 0.041
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0118 0.0105 0.2492
Brugia malayi Trypsin family protein 0.0033 0.0012 0.0011
Brugia malayi beta-lactamase family protein 0.0043 0.0023 0.0023
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0406 0.0418 1
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0406 0.0418 0.0523
Echinococcus granulosus microtubule associated protein 2 0.0833 0.0883 0.0883
Plasmodium falciparum plasmepsin IV 0.0037 0.0016 0.0357
Echinococcus granulosus laminin 0.0026 0.0005 0.0005
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0118 0.0105 0.2457
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0675 0.0711 0.1164
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0033 0.0012 0.0019
Plasmodium vivax subtilisin-like protease 2, putative 0.0406 0.0418 0.986
Schistosoma mansoni hypothetical protein 0.0088 0.0071 0.0071
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0037 0.0016 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.001 0.0017
Mycobacterium tuberculosis Conserved protein 0.0043 0.0023 0.0541
Brugia malayi Trypsin family protein 0.0033 0.0012 0.0011
Brugia malayi aspartic protease BmAsp-1, identical 0.0037 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Mycobacterium ulcerans beta-lactamase 0.0043 0.0023 0.0541
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0001 0.0001
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0084 0.0138
Loa Loa (eye worm) hypothetical protein 0.0088 0.0071 0.0071
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0118 0.0105 0.2492
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0084 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0023 0.0318
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.01 0.0084 0.1178
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0027 0.0375
Echinococcus multilocularis protein kinase c epsilon type 0.01 0.0085 0.0106
Brugia malayi hypothetical protein 0.0097 0.0082 0.0082
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0035 0.0014 0.031
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0023 0.0037
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Trypanosoma cruzi Protein kinase B 0.0023 0.0002 0.0012
Loa Loa (eye worm) transcriptional regulator 0.01 0.0084 0.0084
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.0089 0.1246
Toxoplasma gondii aspartyl protease ASP1 0.0037 0.0016 0.035
Echinococcus multilocularis 0.0118 0.0105 0.0131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0084 0.0138
Onchocerca volvulus 0.0043 0.0023 0.035
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0033 0.0012 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Plasmodium falciparum cysteine proteinase falcipain 3 0.0047 0.0027 0.0629
Onchocerca volvulus 0.0037 0.0017 0.0247
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0009 0.0199
Onchocerca volvulus 0.0023 0.0001 0.0011
Brugia malayi transcriptional regulator, Sir2 family protein 0.0675 0.0711 0.071
Loa Loa (eye worm) hypothetical protein 0.0118 0.0105 0.0104
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0007 0.0091
Brugia malayi Trypsin family protein 0.0118 0.0105 0.0104
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0044 0.0044
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.01 0.0084 0.0105
Schistosoma mansoni serpin 0.0023 0.0001 0.0001
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0023 0.0393
Brugia malayi amine oxidase, flavin-containing family protein 0.0168 0.0158 0.0158
Onchocerca volvulus 0.0023 0.0001 0.0011
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0049 0.003 0.0037
Toxoplasma gondii rhoptry neck protein RON9 0.0037 0.0017 0.0364
Loa Loa (eye worm) hypothetical protein 0.0047 0.0027 0.0027
Echinococcus granulosus cathepsin l1 0.0047 0.0027 0.0027
Onchocerca volvulus 0.0037 0.0017 0.0247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0027 0.0045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Plasmodium vivax subtilisin-like serine protease, putative 0.0406 0.0418 0.986
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.002
Brugia malayi Protein kinase domain containing protein 0.0033 0.0012 0.0012
Echinococcus granulosus protein arginine N methyltransferase 7 0.0035 0.0014 0.0014
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0426 0.0439 0.6179
Plasmodium vivax subtilisin-like protease 1 0.0406 0.0418 0.986
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Toxoplasma gondii calcium binding egf domain-containing protein 0.0026 0.0005 0.0092
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0027 0.0034
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0253 0.0251 0.0251
Plasmodium vivax aspartyl protease, putative 0.0037 0.0016 0.0357
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Brugia malayi NAD-dependent deacetylase SIRT1 0.01 0.0084 0.0084
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Entamoeba histolytica cysteine proteinase 2 0.0024 0.0003 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Echinococcus multilocularis Estrogen regulated protein EP45 0.0023 0.0001 0.0001
Plasmodium falciparum plasmepsin VI 0.0037 0.0016 0.0357
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.01 0.0084 0.0084
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2245 0.242 0.3962
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0002 0.0002
Echinococcus granulosus discoidin domain receptor 0.0033 0.0012 0.0012
Mycobacterium tuberculosis Transcriptional regulatory protein 0.01 0.0084 0.2004
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2245 0.242 0.242
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.0418 0.0685
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0037 0.0016 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Echinococcus granulosus cathepsin l cysteine peptidase 0.0047 0.0027 0.0027
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0062 0.0044 0.1014
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0035 0.0014 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2245 0.242 0.3962
Onchocerca volvulus 0.0406 0.0418 0.6305
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.0003 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Onchocerca volvulus 0.0047 0.0027 0.041
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0003 0.0024
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0675 0.0711 1
Onchocerca volvulus 0.0037 0.0017 0.0247
Brugia malayi serpin 0.0023 0.0001 0.0001
Onchocerca volvulus Putative cubilin 0.0039 0.0018 0.0272
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0406 0.0418 0.0418
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0084 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0675 0.0711 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2245 0.242 0.3962
Plasmodium falciparum plasmepsin III 0.0037 0.0016 0.0357
Brugia malayi hypothetical protein 0.0023 0.0001 0.0001
Echinococcus multilocularis transmembrane protease serine 3 0.0033 0.0012 0.0014
Onchocerca volvulus 0.0071 0.0053 0.0797
Onchocerca volvulus 0.0033 0.0012 0.0174
Brugia malayi BmSERPIN, truncated 0.0023 0.0001 0.0001
Trypanosoma brucei SIR2-like protein 4, putative 0.01 0.0084 0.1178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0027 0.0045
Onchocerca volvulus 0.0037 0.0017 0.0247
Echinococcus multilocularis membrane bound transcription factor site 1 0.0406 0.0418 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.0418 0.0685
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0044 0.0044
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5633 0.6107 0.6107
Loa Loa (eye worm) proprotein convertase 2 0.2245 0.242 0.242
Loa Loa (eye worm) transcriptional regulator 0.0675 0.0711 0.071
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1389 0.1488 0.1488
Leishmania major hypothetical protein, conserved 0.0088 0.0071 0.0995
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Plasmodium falciparum cysteine repeat modular protein 1 0.0088 0.0071 0.1667
Entamoeba histolytica cysteine proteinase 1, putative 0.0024 0.0003 0.0024
Chlamydia trachomatis protoporphyrinogen oxidase 0.0118 0.0105 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0023 0.0541
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0062 0.0044 0.1014
Brugia malayi serpin 0.0023 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0047 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.01 0.0084 0.0228
Plasmodium falciparum plasmepsin I 0.0037 0.0016 0.0357
Brugia malayi Cathepsin L-like precursor 0.0032 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Brugia malayi hypothetical protein 0.0058 0.0039 0.0039
Giardia lamblia High cysteine membrane protein Group 2 0.3388 0.3664 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0023 0.0534
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0027 0.0375
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0118 0.0105 0.2374
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.01 0.0085 0.0085
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0035 0.0014 0.031
Brugia malayi SWIRM domain containing protein 0.0049 0.003 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Mycobacterium tuberculosis Conserved protein 0.0043 0.0023 0.0541
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0016
Plasmodium falciparum transcriptional regulatory protein sir2b 0.01 0.0084 0.1976
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Echinococcus multilocularis Mastin 0.0033 0.0012 0.0014
Echinococcus multilocularis growth factor receptor bound protein 2 0.0259 0.0258 0.0323
Onchocerca volvulus 0.0023 0.0001 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.0089 0.1246
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Brugia malayi hypothetical protein 0.0023 0.0001 0.0001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Brugia malayi Angiotensin-converting enzyme family protein 0.0651 0.0685 0.0685
Mycobacterium ulcerans hypothetical protein 0.0033 0.0012 0.0261
Echinococcus multilocularis glycoprotein Antigen 5 0.0033 0.0012 0.0014
Schistosoma mansoni site-1 peptidase (S08 family) 0.0406 0.0418 0.0418
Loa Loa (eye worm) fibroinase 0.0047 0.0027 0.0027
Plasmodium vivax vivapain-2 0.0047 0.0027 0.0629
Echinococcus multilocularis Estrogen regulated protein EP45 0.0023 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0071 0.0053 0.0053
Leishmania major cathepsin L-like protease 0.0104 0.0089 0.1246
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0118 0.0105 0.2457
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0406 0.0418 0.0418
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.0003 0.0024
Onchocerca volvulus 0.0047 0.0027 0.041
Plasmodium vivax aspartyl protease, putative 0.0037 0.0016 0.0357
Mycobacterium tuberculosis Conserved hypothetical protein 0.0118 0.0105 0.2492
Echinococcus multilocularis serine protease inhibitor 0.0023 0.0001 0.0001
Loa Loa (eye worm) TK/EGFR protein kinase 0.0761 0.0805 0.0805
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0035 0.0014 0.0189
Brugia malayi Sex muscle abnormal protein 5 0.0259 0.0258 0.0258
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0003 0.0024
Echinococcus granulosus cathepsin L 0.0024 0.0003 0.0002
Brugia malayi Cathepsin L-like precursor 0.0047 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Brugia malayi Fibulin-1 precursor 0.0026 0.0005 0.0005
Brugia malayi hypothetical protein 0.0037 0.0017 0.0016
Leishmania major cathepsin L-like protease 0.0047 0.0027 0.0375
Schistosoma mansoni discoidin domain receptor 0.0033 0.0012 0.0012
Trypanosoma cruzi UDP-galactopyranose mutase 0.0118 0.0105 0.1466
Onchocerca volvulus 0.0033 0.0012 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.003 0.0049
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0035 0.0014 0.0189
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0278 0.6649
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0105 0.2457
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0035 0.0014 0.0189
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.0084 0.1178
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0097 0.0082 0.1142
Echinococcus multilocularis geminin 0.0205 0.0199 0.0248
Onchocerca volvulus 0.0037 0.0016 0.0237
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0007 0.0007
Toxoplasma gondii subtilisin SUB11 0.0406 0.0418 0.9653
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0037 0.0016 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Schistosoma mansoni discoidin domain receptor 0.0033 0.0012 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0118 0.0105 0.2492
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0007 0.0154
Echinococcus granulosus cathepsin l1 0.0032 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Trypanosoma brucei rac serine-threonine kinase, putative 0.0043 0.0023 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0018 0.0018
Echinococcus granulosus geminin 0.0205 0.0199 0.0199
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.0055 0.0055
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Echinococcus multilocularis Furin 1 0.2245 0.242 0.3025
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0058 0.0039 0.0039
Toxoplasma gondii histone deacetylase SIR2 0.01 0.0084 0.1934
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0002 0.0012
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.001 0.0136
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0426 0.0439 0.6179
Plasmodium vivax LCCL domain-containing protein 0.0033 0.0012 0.0258
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0023 0.0037
Plasmodium falciparum subtilisin-like protease 1 0.0406 0.0418 0.986
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Echinococcus multilocularis Tolloid protein 1 0.0046 0.0026 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0011
Echinococcus granulosus Estrogen regulated protein EP45 0.0023 0.0001 0.0001
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0005 0.0005
Toxoplasma gondii aspartyl protease ASP5 0.0375 0.0384 0.8869
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0075 0.0058 0.0058
Leishmania major cathepsin L-like protease 0.0047 0.0027 0.0375
Trypanosoma cruzi cysteine protease, putative 0.0024 0.0003 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0003 0.0002
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0118 0.0105 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.003 0.0049
Brugia malayi Serpin protein 6 0.0023 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0024 0.0024
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0001 0.0001
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0037 0.0016 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0003 0.0024
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0044 0.0024 0.0024
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.01 0.0084 0.1178
Schistosoma mansoni protein arginine n-methyltransferase 0.0035 0.0014 0.0014
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.01 0.0084 0.1178
Schistosoma mansoni septate junction protein 0.0052 0.0033 0.0033
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0084 0.0138
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0042 0.0041
Brugia malayi angiogenesis inhibito 0.0026 0.0004 0.0004
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1839 0.1977 0.3238
Echinococcus multilocularis C type lectin domian containing protein 0.0037 0.0017 0.002
Loa Loa (eye worm) hypothetical protein 0.0118 0.0105 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0027 0.0045
Echinococcus multilocularis 0.7371 0.7999 1
Brugia malayi beta-lactamase family protein 0.0043 0.0023 0.0023
Schistosoma mansoni growth factor receptor-bound protein 0.0259 0.0258 0.0258
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0007 0.0154
Loa Loa (eye worm) hypothetical protein 0.01 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.3577 0.3869 0.3869
Echinococcus multilocularis cysteine protease 0.0047 0.0027 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0035 0.0014 0.0189
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0001 0.5
Entamoeba histolytica hypothetical protein 0.0049 0.003 0.0407
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0016
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0084 0.0138
Schistosoma mansoni serpin 0.0023 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Brugia malayi Cathepsin L-like precursor 0.0047 0.0027 0.0027
Onchocerca volvulus 0.0287 0.0288 0.4339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Echinococcus multilocularis protein kinase c iota type 0.0026 0.0005 0.0006
Echinococcus multilocularis protein will die slowly 0.0287 0.0288 0.036
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0711 0.071
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0033 0.0012 0.0011
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1839 0.1977 0.3238
Brugia malayi hypothetical protein 0.0037 0.0017 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0027 0.0045
Onchocerca volvulus 0.0023 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0406 0.0418 0.0418
Mycobacterium tuberculosis Conserved protein 0.0043 0.0023 0.0541
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0027 0.0027
Leishmania major sir2-family protein-like protein 0.01 0.0084 0.1178
Mycobacterium ulcerans lipase LipD 0.0043 0.0023 0.0541
Plasmodium falciparum transcriptional regulatory protein sir2a 0.01 0.0084 0.1976
Echinococcus granulosus transmembrane protease serine 3 0.0033 0.0012 0.0011
Brugia malayi cathepsin L-like precursor 0.0032 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0582 0.061 0.061
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0016 0.0357
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0012 0.0014
Toxoplasma gondii SWIRM domain-containing protein 0.0049 0.003 0.0668
Leishmania major arginine N-methyltransferase, type I 0.0035 0.0014 0.0189
Echinococcus granulosus C type lectin domian containing protein 0.0037 0.0017 0.0016
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0033 0.0012 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0042 0.0041
Echinococcus granulosus neuroendocrine convertase 2 0.5822 0.6312 0.6312
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Plasmodium falciparum cysteine proteinase falcipain 1 0.0024 0.0003 0.0041
Onchocerca volvulus 0.0037 0.0017 0.0247
Mycobacterium ulcerans monoamine oxidase 0.0118 0.0105 0.2492
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0711 0.071
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0406 0.0418 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.01 0.0084 0.0084
Toxoplasma gondii aspartyl protease 0.0037 0.0016 0.035
Plasmodium vivax vivapain-1 0.0024 0.0003 0.0041
Echinococcus granulosus lysine specific histone demethylase 1A 0.0582 0.061 0.061
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0027 0.041
Brugia malayi Cathepsin L-like cysteine proteinase 0.0032 0.001 0.001
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0259 0.0258 0.0258
Trichomonas vaginalis esterase, putative 0.0043 0.0023 0.0038
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0033 0.0012 0.0012
Onchocerca volvulus 0.0047 0.0027 0.041
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0005 0.0005
Onchocerca volvulus 0.0033 0.0012 0.0173
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0062 0.0044 0.0993
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0007 0.0154
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0023 0.0023
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0582 0.061 0.061
Onchocerca volvulus 0.0033 0.0012 0.0173
Echinococcus multilocularis c4b binding protein beta chain 0.0037 0.0017 0.002
Schistosoma mansoni hypothetical protein 0.0041 0.0021 0.0021
Echinococcus multilocularis enteropeptidase 0.0033 0.0012 0.0014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0042 0.0041
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Echinococcus multilocularis protein arginine methyltransferase 0.0062 0.0044 0.0054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Echinococcus multilocularis fibrillin 1 0.0029 0.0007 0.0009
Entamoeba histolytica protein kinase, putative 0.0043 0.0023 0.031
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0035 0.0014 0.0014
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0047 0.0027 0.0629
Onchocerca volvulus 0.0033 0.0012 0.0173
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0406 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Onchocerca volvulus 0.0037 0.0017 0.0247
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0023 0.0541
Schistosoma mansoni hypothetical protein 0.0287 0.0288 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0037 0.0016 0.0016
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5633 0.6107 1
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0002 0.0001
Toxoplasma gondii calcium binding egf domain-containing protein 0.0026 0.0005 0.0092
Echinococcus multilocularis neuroendocrine convertase 2 0.5822 0.6312 0.7892
Echinococcus multilocularis serine:threonine protein kinase N2 0.0092 0.0076 0.0095
Toxoplasma gondii subtilisin SUB4 0.0406 0.0418 0.9653
Toxoplasma gondii F5/8 type C domain-containing protein 0.0033 0.0012 0.0253
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0118 0.0105 0.2457
Echinococcus granulosus cathepsin L cysteine proteinase 0.0047 0.0027 0.0027
Toxoplasma gondii AGC kinase 0.0041 0.0021 0.0457
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0029
Leishmania major UDP-galactopyranose mutase 0.0118 0.0105 0.1466
Onchocerca volvulus 0.0047 0.0027 0.041
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0037 0.0017 0.0016
Brugia malayi Eukaryotic aspartyl protease family protein 0.0037 0.0016 0.0016
Loa Loa (eye worm) TK/ROR protein kinase 0.0088 0.0071 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0027 0.0045
Toxoplasma gondii subtilisin SUB1 0.0406 0.0418 0.9653
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0003 0.0002
Echinococcus granulosus tissue type plasminogen activator 0.0088 0.0071 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0027 0.0045
Echinococcus multilocularis protoporphyrinogen oxidase 0.0118 0.0105 0.0131
Brugia malayi Cathepsin L-like precursor 0.0032 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0023 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0105 0.2457
Loa Loa (eye worm) AGC/AKT protein kinase 0.0043 0.0023 0.0023
Brugia malayi Will die slowly protein 0.0287 0.0288 0.0288
Brugia malayi hypothetical protein 0.0037 0.0017 0.0016
Echinococcus multilocularis discoidin domain containing receptor 2 0.0033 0.0012 0.0014
Echinococcus multilocularis laminin 0.0026 0.0005 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2245 0.242 0.3962
Loa Loa (eye worm) beta-lactamase 0.0043 0.0023 0.0023
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0426 0.0439 0.6179
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0026 0.0005 0.0005
Brugia malayi Kringle domain containing protein 0.0088 0.0071 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.0003 0.0024
Loa Loa (eye worm) ctsf protein 0.0047 0.0027 0.0027
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0675 0.0711 1
Giardia lamblia Sirtuin type 2 0.01 0.0084 0.0228
Echinococcus granulosus membrane bound transcription factor site 1 0.0406 0.0418 0.0418
Onchocerca volvulus 0.0071 0.0053 0.0797
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0084 0.0138
Echinococcus granulosus growth factor receptor bound protein 2 0.0259 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0118 0.0105 0.0105
Entamoeba histolytica protein kinase, putative 0.0041 0.0021 0.0278
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Loa Loa (eye worm) serpin 0.0023 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0043 0.0023 0.0318
Echinococcus granulosus lysine specific histone demethylase 1A 0.0118 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.0418 0.0685
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.0084 0.1178
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.001
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Brugia malayi serpin (BmSERPIN) 0.0023 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0037 0.0017 0.0247
Schistosoma mansoni memapsin-2 (A01 family) 0.0037 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0027 0.0045
Echinococcus granulosus Protein kinase C brain isozyme 0.0028 0.0006 0.0006
Onchocerca volvulus 0.0085 0.0069 0.1038
Plasmodium vivax plasmepsin IV, putative 0.0037 0.0016 0.0357
Onchocerca volvulus 0.0088 0.0071 0.1074
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0035 0.0014 0.0189
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0027 0.0027
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.01 0.0084 0.1976
Brugia malayi hypothetical protein 0.0033 0.0012 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.0089 0.1246
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0006 0.0006
Echinococcus granulosus methyltransferase protein 5 0.0035 0.0014 0.0014
Toxoplasma gondii ABC1 family protein 0.0043 0.0023 0.0523
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0027 0.0375
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0041 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0205 0.0199 0.0199
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0007 0.0154
Plasmodium vivax vivapain-2 0.0047 0.0027 0.0629
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0097 0.0082 0.1142
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0007 0.0154
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0001 0.0001
Brugia malayi ADAM-TS Spacer 1 family protein 0.0026 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.01 0.0084 0.0105
Echinococcus granulosus protein will die slowly 0.0287 0.0288 0.0288
Trichomonas vaginalis WD repeat domain, putative 0.0287 0.0288 0.0472
Leishmania major arginine N-methyltransferase-like protein 0.0062 0.0044 0.0605
Plasmodium falciparum plasmepsin V 0.0412 0.0424 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Entamoeba histolytica SWIRM domain protein 0.0049 0.003 0.0407
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0001 0.0001
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0035 0.0014 0.0189
Leishmania major silent information regulator 2, putative 0.0675 0.0711 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0007 0.0154
Echinococcus granulosus discoidin domain containing receptor 2 0.0033 0.0012 0.0012
Onchocerca volvulus 0.0224 0.022 0.3311
Leishmania major cathepsin L-like protease 0.0104 0.0089 0.1246
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0675 0.0711 0.071
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0012 0.0011
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0002 0.0001
Loa Loa (eye worm) transcriptional regulator 0.01 0.0084 0.0084
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0009 0.0199
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0023 0.0038
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0023 0.0541
Toxoplasma gondii rhoptry neck protein RON1 0.0037 0.0017 0.0364
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0011
Mycobacterium ulcerans NAD-dependent deacetylase 0.01 0.0084 0.2004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0205 0.0199 0.0199
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0675 0.0711 0.1164
Plasmodium vivax NAD-dependent deacetylase, putative 0.01 0.0084 0.1976
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0033 0.0012 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0003 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0009 0.0199
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0023 0.0318
Echinococcus multilocularis tissue type plasminogen activator 0.0088 0.0071 0.0089
Echinococcus granulosus Estrogen regulated protein EP45 0.0023 0.0001 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0023 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Loa Loa (eye worm) serpin 0.0023 0.0001 0.0001
Echinococcus granulosus protein arginine N methyltransferase 8 0.0062 0.0044 0.0044
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0406 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.001
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0033 0.0012 0.0109
Echinococcus granulosus cysteine protease 0.0024 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0071 0.0053 0.0053
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0118 0.0105 0.2406
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.0883 0.1104
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.0084 0.0084
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0009 0.0118
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Brugia malayi SWIRM domain containing protein 0.0631 0.0663 0.0663
Giardia lamblia Furin precursor putative serine protease 0.1839 0.1977 0.5396
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0002 0.0012
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0406 0.0418 1
Toxoplasma gondii cathepsin CPL 0.0047 0.0027 0.0616
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Echinococcus granulosus Furin 1 0.2245 0.242 0.242
Onchocerca volvulus 0.0631 0.0663 1
Echinococcus granulosus MAM 0.0071 0.0053 0.0053
Toxoplasma gondii subtilisin SUB7 0.0406 0.0418 0.9653
Brugia malayi hypothetical protein 0.0037 0.0017 0.0016
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0062 0.0044 0.0054
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0014 0.0023
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0047 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Brugia malayi Probable ATP-dependent helicase DHX35 0.0034 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Brugia malayi hypothetical protein 0.0037 0.0017 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Echinococcus granulosus discoidin domain containing receptor 2 0.0033 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0016
Loa Loa (eye worm) reprolysin 0.0044 0.0024 0.0024
Brugia malayi Subtilase family protein 0.0406 0.0418 0.0418
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0711 0.071
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0024 0.0003 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.0071 0.0995
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0047 0.0027 0.0629
Plasmodium vivax aspartyl protease, putative 0.0037 0.0016 0.0357
Echinococcus granulosus enteropeptidase 0.0033 0.0012 0.0011
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0084 0.0138
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0009 0.0118
Echinococcus granulosus serine protease inhibitor 0.0023 0.0001 0.0001
Brugia malayi Trypsin family protein 0.0033 0.0012 0.0011
Brugia malayi Furin-like cysteine rich region family protein 0.0761 0.0805 0.0805
Loa Loa (eye worm) hypothetical protein 0.0034 0.0013 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5633 0.6107 1
Toxoplasma gondii bicoid-interacting protein BIN3 0.0035 0.0014 0.031
Brugia malayi GCC2 and GCC3 family protein 0.0057 0.0038 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.0003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0057 0.0038 0.0037
Onchocerca volvulus 0.0043 0.0023 0.035
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0023 0.0318
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Brugia malayi ADAMTS-like protease 0.0026 0.0004 0.0004
Brugia malayi hypothetical protein 0.0071 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0097 0.0082 0.0082
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0016 0.0016
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0088 0.0072 0.1007
Schistosoma mansoni hypothetical protein 0.0071 0.0053 0.0053
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.0003 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Echinococcus granulosus dnaJ subfamily B 0.0396 0.0408 0.0407
Echinococcus multilocularis epidermal growth factor receptor 0.0761 0.0805 0.1006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0007 0.0091
Loa Loa (eye worm) hypothetical protein 0.0168 0.0158 0.0158
Plasmodium falciparum LCCL domain-containing protein 0.0033 0.0012 0.0258
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.0084 0.0084
Echinococcus granulosus protein kinase c epsilon type 0.01 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Plasmodium falciparum plasmepsin VII 0.0037 0.0016 0.0357
Toxoplasma gondii PA14 domain-containing protein 0.0033 0.0012 0.0253
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0023 0.0541
Leishmania major cathepsin L-like protease 0.0047 0.0027 0.0375
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0651 0.0685 0.0685
Schistosoma mansoni egf-like domain protein 0.0026 0.0005 0.0005
Plasmodium falciparum protoporphyrinogen oxidase 0.0118 0.0105 0.2457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Onchocerca volvulus 0.0043 0.0023 0.035
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Brugia malayi Cathepsin L-like precursor 0.0047 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0396 0.0408 0.0407
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0582 0.061 0.0762
Echinococcus granulosus Tolloid protein 1 0.0046 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0027 0.0045
Plasmodium falciparum plasmepsin II 0.0037 0.0016 0.0357
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0023 0.0037
Loa Loa (eye worm) hypothetical protein 0.0582 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0023 0.0037
Mycobacterium ulcerans oxidoreductase 0.0118 0.0105 0.2492
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0003 0.0024
Giardia lamblia Transcriptional regulator, Sir2 family 0.01 0.0084 0.0228
Leishmania major subtilisin-like serine peptidase 0.0406 0.0418 0.5881
Echinococcus granulosus Mastin 0.0033 0.0012 0.0011
Brugia malayi serpin 0.0023 0.0001 0.0001
Echinococcus multilocularis adam 0.0058 0.0039 0.0049
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0085 0.0085
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0012 0.0011
Mycobacterium ulcerans Sir2-like regulatory protein 0.01 0.0084 0.2004
Toxoplasma gondii histone lysine-specific demethylase 0.0118 0.0105 0.2406
Schistosoma mansoni dock 0.0033 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0007 0.0154
Echinococcus granulosus cathepsin L cysteine protease 0.0024 0.0003 0.0002
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0044 0.0072
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0023 0.0001 0.0003
Schistosoma mansoni amine oxidase 0.0118 0.0105 0.0105
Schistosoma mansoni tyrosine kinase 0.0761 0.0805 0.0805
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5633 0.6107 0.7636
Brugia malayi celfurPC protein 0.7371 0.7999 0.7999
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Echinococcus granulosus epidermal growth factor receptor 0.0761 0.0805 0.0805
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0023 0.0541
Giardia lamblia Hypothetical protein 0.0675 0.0711 0.1938
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Echinococcus granulosus glycoprotein Antigen 5 0.0033 0.0012 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0675 0.0711 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.0418 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Brugia malayi Sushi domain 0.0037 0.0017 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0023 0.0038
Brugia malayi serpin 0.0023 0.0001 0.0001
Echinococcus multilocularis MAM 0.0071 0.0053 0.0066
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0406 0.0418 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0033 0.0012 0.0019
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0027 0.0034
Mycobacterium tuberculosis Possible oxidoreductase 0.0118 0.0105 0.2492
Plasmodium falciparum plasmepsin VIII, putative 0.0037 0.0016 0.0357
Brugia malayi Cathepsin L-like precursor 0.0047 0.0027 0.0027
Leishmania major cathepsin L-like protease 0.0047 0.0027 0.0375
Toxoplasma gondii subtilisin SUB6 0.0406 0.0418 0.9653
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.001
Brugia malayi p70 ribosomal S6 kinase beta 0.0041 0.0021 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.0418 0.0685
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0406 0.0418 0.0418
Echinococcus multilocularis discoidin domain receptor 0.0033 0.0012 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0027 0.0045
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0097 0.0082 0.1142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0003 0.0004
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0014 0.0023
Brugia malayi serpin 0.0023 0.0001 0.0001
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0049 0.003 0.0029
Echinococcus granulosus adam 0.0058 0.0039 0.0039
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0024 0.0024
Schistosoma mansoni btb and poz domain-containing protein 0.0033 0.0012 0.0012
Echinococcus granulosus protein arginine methyltransferase 0.0062 0.0044 0.0044
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0406 0.0418 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0118 0.0105 0.2457
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0001 0.0001
Echinococcus multilocularis chromatin regulatory protein sir2 0.0675 0.0711 0.0888
Brugia malayi Pepsin A precursor 0.0037 0.0016 0.0016
Toxoplasma gondii F5/8 type C domain-containing protein 0.0033 0.0012 0.0253
Trypanosoma brucei Silent information regulator 2 related protein 3 0.01 0.0084 0.1178
Entamoeba histolytica hypothetical protein 0.0097 0.0082 0.1142
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0007 0.0091
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0007 0.0091
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0675 0.0711 0.0888
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0406 0.0418 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0003 0.0002
Loa Loa (eye worm) sirtuin 4 0.01 0.0084 0.0084
Echinococcus multilocularis serine protease inhibitor 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0037 0.0017 0.0247
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1839 0.1977 0.3238
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Brugia malayi hypothetical protein 0.0118 0.0105 0.0105
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.001 0.001
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0046 0.0026 0.0026
Plasmodium vivax plasmepsin V, putative 0.0412 0.0424 1
Entamoeba histolytica hypothetical protein, conserved 0.01 0.0084 0.1178
Loa Loa (eye worm) serpin protein 6 0.0023 0.0001 0.0001
Brugia malayi aspartic protease BmAsp-2, identical 0.0037 0.0016 0.0016
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0027 0.0034
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0406 0.0418 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0011
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0016 0.0016
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0018
Onchocerca volvulus 0.0023 0.0001 0.0011
Brugia malayi Protein kinase domain containing protein 0.0071 0.0053 0.0053
Onchocerca volvulus 0.0033 0.0012 0.0173
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0007 0.0007
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0016 0.0357
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0007 0.0091
Toxoplasma gondii subtilisin SUB12 0.042 0.0433 1
Toxoplasma gondii subtilisin SUB10 0.0406 0.0418 0.9653
Brugia malayi hypothetical protein 0.0037 0.0017 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0027 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0027 0.0027
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.01 0.0084 0.0084
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0675 0.0711 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0007 0.0154
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0003 0.0002
Loa Loa (eye worm) WD40 repeat protein 0.0287 0.0288 0.0288
Toxoplasma gondii kringle domain-containing protein 0.0088 0.0071 0.1632
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0088 0.0071 0.1667
Entamoeba histolytica SWIRM domain protein 0.0049 0.003 0.0407
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0044 0.0024 0.003
Trypanosoma cruzi cruzipain precursor, putative 0.0104 0.0089 0.1246
Brugia malayi proprotein convertase 2 0.5822 0.6312 0.6312
Echinococcus multilocularis discoidin domain containing receptor 2 0.0033 0.0012 0.0014
Onchocerca volvulus 0.0041 0.0021 0.0307
Schistosoma mansoni ap endonuclease 0.0023 0.0001 0.0001
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.0408 0.0509
Schistosoma mansoni c4b-binding protein beta chain 0.0037 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0118 0.0105 0.0105
Loa Loa (eye worm) cysteine protease 0.0047 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0032 0.001 0.0154
Schistosoma mansoni SWI/SNF complex-related 0.0049 0.003 0.0029
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0044 0.0044
Echinococcus multilocularis cathepsin L 0.0024 0.0003 0.0003
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0023 0.0541
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Toxoplasma gondii subtilisin SUB8 0.0406 0.0418 0.9653
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Toxoplasma gondii aspartyl protease ASP3 0.0037 0.0016 0.035
Loa Loa (eye worm) aspartyl protease 6 0.0037 0.0016 0.0016
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0002 0.0001
Echinococcus granulosus plasminogen activator inhibitor 2 0.0023 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Onchocerca volvulus 0.0047 0.0027 0.041
Loa Loa (eye worm) DEAH box polypeptide 35 0.0034 0.0013 0.0012
Brugia malayi protein kinase C II. 0.01 0.0085 0.0085
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0118 0.0105 0.0105
Loa Loa (eye worm) trypsin family protein 0.0033 0.0012 0.0011
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0033 0.0012 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0027 0.0045
Plasmodium falciparum LCCL domain-containing protein 0.0033 0.0012 0.0258
Schistosoma mansoni furin-1 (S08 family) 0.3983 0.4311 0.4311
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0033 0.0012 0.0014
Echinococcus granulosus chromatin regulatory protein sir2 0.0675 0.0711 0.071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0027 0.0045
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0035 0.0014 0.0189
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0001 0.0001
Echinococcus granulosus serine protease inhibitor 0.0023 0.0001 0.0001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0116 0.0102 0.0102
Schistosoma mansoni atypical protein kinase C 0.0026 0.0005 0.0004
Trypanosoma cruzi UDP-galactopyranose mutase 0.0118 0.0105 0.1466
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Mycobacterium leprae Probable lipase LipE 0.0043 0.0023 0.0393
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0011
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0001 0.0001
Toxoplasma gondii subtilisin SUB2 0.0406 0.0418 0.9653
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0027 0.041
Plasmodium vivax LCCL domain-containing protein 0.0033 0.0012 0.0258
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Onchocerca volvulus 0.0037 0.0017 0.0247
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0007 0.0154
Toxoplasma gondii histone deacetylase SIR2-like 0.01 0.0084 0.1934
Schistosoma mansoni amine oxidase 0.0118 0.0105 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0007 0.0091
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0009 0.0118
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0023 0.0541
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0097 0.0082 0.1142
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0011
Loa Loa (eye worm) serpin 0.0023 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0007 0.0154
Giardia lamblia hypothetical protein 0.0049 0.003 0.0079
Brugia malayi Reprolysin 0.0026 0.0004 0.0004
Toxoplasma gondii subtilisin SUB9 0.0406 0.0418 0.9653
Echinococcus granulosus serine protease inhibitor 0.0023 0.0001 0.0001
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.0047 0.0656
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0044 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0089 0.1246
Brugia malayi Carm1-pending protein 0.0035 0.0014 0.0014
Echinococcus granulosus c4b binding protein beta chain 0.0037 0.0017 0.0016
Entamoeba histolytica protein kinase, putative 0.0043 0.0023 0.031
Mycobacterium ulcerans hypothetical protein 0.0043 0.0023 0.0541
Brugia malayi Protein arginine N-methyltransferase 0.0035 0.0014 0.0014
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0002 0.0012
Schistosoma mansoni ap endonuclease 0.0023 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2245 0.242 0.3962
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0084 0.0138
Brugia malayi serpin (BmSERPIN) 0.0023 0.0001 0.0001
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0406 0.0418 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0044 0.0072
Schistosoma mansoni site-1 peptidase (S08 family) 0.0406 0.0418 0.0418
Schistosoma mansoni hypothetical protein 0.1839 0.1977 0.1977
Plasmodium vivax apical sushi protein, putative 0.0037 0.0017 0.0372
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0037 0.0016 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0012 0.0011
Schistosoma mansoni growth factor receptor-bound protein 0.0259 0.0258 0.0258
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.01 0.0084 0.0105
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0035 0.0014 0.0017
Plasmodium falciparum plasmepsin X 0.0037 0.0016 0.0357
Plasmodium vivax vivapain-3 0.0024 0.0003 0.0041
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0023 0.0038
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0057 0.0799
Entamoeba histolytica cysteine protease, putative 0.0024 0.0003 0.0024
Plasmodium falciparum plasmepsin IX 0.0037 0.0016 0.0357
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0011
Brugia malayi serpin precursor 0.0023 0.0001 0.0001
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0035 0.0014 0.0014
Loa Loa (eye worm) Carm1-pending protein 0.0035 0.0014 0.0014
Echinococcus granulosus discoidin domain containing receptor 2 0.0033 0.0012 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0023 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.001 0.0017
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0033 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.006 0.0042 0.0041
Brugia malayi neuroendocrine convertase 1 precursor 0.5822 0.6312 0.6312
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0001 0.5
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0028 0.0006 0.0007
Onchocerca volvulus 0.0033 0.0012 0.0174
Brugia malayi Trypsin-like protease protein 5 0.0033 0.0012 0.0011
Onchocerca volvulus 0.0037 0.0017 0.0247
Trichomonas vaginalis hypothetical protein 0.1839 0.1977 0.3238
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0041 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Leishmania major cysteine peptidase A (CPA) 0.0047 0.0027 0.0375
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.0084 0.0084
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0012 0.0011
Mycobacterium ulcerans dehydrogenase 0.0118 0.0105 0.2492
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0001 0.0001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0023 0.0541
Loa Loa (eye worm) TK/ALK protein kinase 0.0071 0.0053 0.0053
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0406 0.0418 0.5881
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Toxoplasma gondii protease inhibitor PI1 0.0023 0.0001 0.0003
Echinococcus granulosus protein kinase c iota type 0.0026 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0138 0.0126 0.0126
Onchocerca volvulus 0.0037 0.0016 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.1839 0.1977 0.3238
Loa Loa (eye worm) hypothetical protein 0.0631 0.0663 0.0663
Brugia malayi hypothetical protein 0.003 0.0009 0.0009
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0009 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0019
Loa Loa (eye worm) serpin 0.0023 0.0001 0.0001
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.0084 0.0084
Trypanosoma cruzi subtilisin peptidase 0.0406 0.0418 0.5881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2245 0.242 0.3962
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0012 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0047 0.0027 0.041
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.0104 0.0089 0.1246
Onchocerca volvulus 0.0029 0.0007 0.0106
Brugia malayi beta-lactamase 0.0043 0.0023 0.0023
Plasmodium falciparum subtilisin-like protease 2 0.0406 0.0418 0.986
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0014 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0014
Echinococcus multilocularis cysteine protease 0.0047 0.0027 0.0034
Plasmodium vivax unspecified product 0.0024 0.0003 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.0418 0.0685

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 99 uM PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504720, AID504743] ChEMBL. No reference
EC50 (functional) > 99 uM PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504720, AID504743] ChEMBL. No reference
Potency (functional) 0.5805 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)] ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay. (Class of assay: confirmatory) [Related pubchem assays: 1476 (Cruzain without detergent), 1478 (Cruzain with detergent)] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (functional) 5.3582 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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