Detailed information for compound 234390

Basic information

Technical information
  • TDR Targets ID: 234390
  • Name: 2-(2-benzoylpyrrol-1-yl)acetic acid
  • MW: 229.231 | Formula: C13H11NO3
  • H donors: 1 H acceptors: 3 LogP: 2.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cn1cccc1C(=O)c1ccccc1
  • InChi: 1S/C13H11NO3/c15-12(16)9-14-8-4-7-11(14)13(17)10-5-2-1-3-6-10/h1-8H,9H2,(H,15,16)
  • InChiKey: IIBKYEGOAYTTFM-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(2-benzoyl-1-pyrrolyl)acetic acid
  • 2-[2-(phenylcarbonyl)pyrrol-1-yl]ethanoic acid
  • 2-[2-(benzoyl)pyrrol-1-yl]acetic acid
  • 2-[2-(oxo-phenylmethyl)-1-pyrrolyl]acetic acid
  • 2-(2-phenylcarbonylpyrrol-1-yl)ethanoic acid
  • ChemDiv2_002848
  • (2-benzoyl-1H-pyrrol-1-yl)acetic acid
  • MLS000095834
  • SMR000031382

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Homo sapiens arachidonate 12-lipoxygenase Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Pseudomonas aeruginosa Beta Lactamase Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans class a beta-lactamase, BlaC Get druggable targets OG5_143180 All targets in OG5_143180
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Class a beta-lactamase BlaC Get druggable targets OG5_143180 All targets in OG5_143180
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 12-lipoxygenase 663 aa 662 aa 22.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis General substrate transporter 0.0135 0.1541 0.1539
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0005 0.0002
Leishmania major hypothetical protein, conserved 0.0008 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0151 0.1861
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0008 0.0005 0.002
Brugia malayi Cytochrome P450 family protein 0.0008 0.0005 0.0002
Plasmodium vivax hexose transporter 0.0157 0.1808 0.2267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0048 0.049 0.0671
Echinococcus granulosus geminin 0.0205 0.2388 0.2386
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0041 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0048 0.049 0.0671
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.015 0.1754
Onchocerca volvulus Peroxidasin homolog 0.0078 0.0854 0.2902
Brugia malayi Carboxylesterase family protein 0.0012 0.0054 0.0071
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0225 0.0307
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0008 0.0005 0.0009
Echinococcus multilocularis musashi 0.0033 0.0305 0.0302
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0048 0.0492 0.0489
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0008 0.0003 0.0004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0138 0.073
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Echinococcus granulosus solute carrier family 22 0.0022 0.0177 0.0174
Echinococcus granulosus RUN 0.0063 0.0672 0.0669
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0276 0.0273
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0048 0.0492 0.0674
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0221 0.0218
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.015 0.185
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.002
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0055 0.0071
Trypanosoma brucei glucose transporter, putative 0.0049 0.0499 0.5914
Echinococcus granulosus lamin dm0 0.0033 0.0305 0.0302
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0157 0.1808 0.1806
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0008 0.0005 0.0009
Loa Loa (eye worm) sugar transporter 0.0157 0.1808 0.249
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0238 0.2792 0.2789
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0071
Schistosoma mansoni sugar transporter 0.0022 0.0177 0.0174
Schistosoma mansoni BC026374 protein (S09 family) 0.0012 0.0054 0.0051
Trypanosoma cruzi hexose transporter, putative 0.0049 0.0499 0.8283
Brugia malayi Doublecortin family protein 0.0063 0.0672 0.0922
Loa Loa (eye worm) hypothetical protein 0.0048 0.049 0.0671
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.072 0.1361
Onchocerca volvulus 0.0033 0.0305 0.1029
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0305 0.0416
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0048 0.049 0.0487
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.015 0.0203
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0005 0.0028
Loa Loa (eye worm) cytochrome P450 0.0008 0.0005 0.0002
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0241 0.0238
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0151 0.0148
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Brugia malayi Major Facilitator Superfamily protein 0.0022 0.0177 0.0241
Leishmania major glucose transporter/membrane transporter D2, putative 0.0049 0.0499 0.6238
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0022 0.0177 0.0944
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0032
Echinococcus granulosus FTZ F1 alpha 0.0048 0.049 0.0487
Schistosoma mansoni lysyl-tRNA synthetase 0.0035 0.0334 0.0331
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.049 0.0487
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Loa Loa (eye worm) hypothetical protein 0.0046 0.0464 0.0636
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0177 0.0606
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0221 0.03
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0197
Plasmodium vivax multidomain scavenger receptor, putative 0.0063 0.0672 0.084
Brugia malayi ecdysteroid receptor 0.0048 0.049 0.0671
Trichomonas vaginalis ras GTP exchange factor, putative 0.0008 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.049 0.0671
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0151 0.1734 0.1731
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0048 0.049 0.0671
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0048 0.0492 0.0489
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0008 0.0005 0.0009
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0038 0.0372 0.0369
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0138 0.073
Giardia lamblia DNA repair protein RAD52 0.0347 0.4111 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1488 0.894
Loa Loa (eye worm) glutathione reductase 0.0057 0.0602 0.0826
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0253 0.4165
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0151 0.1764
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0225 0.1203
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0008 0.0003 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0798 0.1509
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0217 0.0294
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0046 0.0043
Entamoeba histolytica hypothetical protein 0.0008 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0151 0.1734 0.4214
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0184 0.0181
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0005 0.0002
Brugia malayi Pre-SET motif family protein 0.0032 0.0299 0.0409
Schistosoma mansoni hypothetical protein 0.0157 0.1808 0.1806
Leishmania major cytochrome p450-like protein 0.0008 0.0005 0.0021
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5891 0.589
Echinococcus multilocularis synaptic vesicle 2 protein 0.0022 0.0177 0.0174
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.0135
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0041 0.0038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0151 0.0204
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.016 0.1851 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0048 0.049 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0048 0.049 0.0671
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0005 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0579 0.0577
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0138 0.2251
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0225 0.0307
Brugia malayi conserved hypotetical protein 0.0023 0.0184 0.0249
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1495 0.2058
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1664 0.8986
Trypanosoma brucei THT1 - hexose transporter, putative 0.0049 0.0499 0.5914
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0241 0.0238
Trypanosoma brucei beta lactamase 0.0077 0.0842 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0225 0.1339
Plasmodium vivax importin-beta 2, putative 0.0035 0.0332 0.0413
Plasmodium vivax lysine--tRNA ligase, putative 0.0035 0.0334 0.0416
Trichomonas vaginalis glucose transporter, putative 0.0022 0.0177 0.0606
Loa Loa (eye worm) hypothetical protein 0.0063 0.0672 0.0922
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0008 0.0005 0.0009
Echinococcus multilocularis acetylcholinesterase 0.007 0.076 0.0757
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0492 0.1678
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0022 0.0177 0.0219
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0048 0.0492 0.0489
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0008 0.0005 0.0009
Schistosoma mansoni smad 0.0009 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.0048 0.049 0.0671
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0221 0.03
Brugia malayi hypothetical protein 0.0011 0.0041 0.0052
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0138 0.1607
Onchocerca volvulus Bile acid receptor homolog 0.0048 0.049 0.1659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0241 0.0822
Onchocerca volvulus Protein ultraspiracle homolog 0.0048 0.049 0.1659
Schistosoma mansoni glucose transport protein 0.0157 0.1808 0.1806
Echinococcus granulosus solute carrier family 22 0.0022 0.0177 0.0174
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0008 0.0005 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0499 0.1703
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0008 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0218 0.255 0.3513
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.015 0.0796
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0305 0.0416
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.015 0.0185
Echinococcus granulosus solute carrier family 22 0.0022 0.0177 0.0174
Echinococcus granulosus death domain containing protein 0.0045 0.046 0.0457
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0854 0.1174
Mycobacterium ulcerans integral membrane transport protein 0.0022 0.0177 0.0944
Plasmodium vivax sugar transporter, putative 0.0022 0.0177 0.0219
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.0492 0.0489
Echinococcus granulosus jun protein 0.0088 0.0978 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0046 0.0158
Loa Loa (eye worm) hypothetical protein 0.0048 0.049 0.0671
Echinococcus granulosus smad 0.0009 0.0019 0.0016
Trypanosoma brucei glucose transporter, putative 0.0049 0.0499 0.5914
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.255 0.8684
Brugia malayi Carboxylesterase family protein 0.0012 0.0054 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0499 0.1703
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0054 0.0051
Trypanosoma brucei THT1 - hexose transporter, putative 0.0049 0.0499 0.5914
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0071
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0031 0.0282 0.0962
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0029 0.0026
Schistosoma mansoni acetylcholinesterase 0.0012 0.0054 0.0051
Brugia malayi hypothetical protein 0.0151 0.1734 0.2387
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0579 0.0795
Brugia malayi steroid hormone receptor 0.0048 0.049 0.0671
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.002
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0184 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Schistosoma mansoni ap endonuclease 0.0019 0.0138 0.0135
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0373 0.051
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.015 0.1754
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0054 0.0277
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0009 0.0017 0.024
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0062 0.0699
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0221 0.0497
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0047 0.048 0.0477
Echinococcus multilocularis lamin 0.0033 0.0305 0.0302
Trichomonas vaginalis ras GTP exchange factor, putative 0.0008 0.0003 0.0011
Loa Loa (eye worm) Smad1 0.0009 0.0019 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.049 0.0487
Echinococcus granulosus ecdysone induced protein 78C 0.0048 0.049 0.0487
Echinococcus granulosus netrin receptor unc 5 0.0045 0.046 0.0457
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0499 0.1703
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0184 0.0616
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.015 0.8297
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.015 0.0185
Brugia malayi Blistered cuticle protein 3 0.0078 0.0854 0.1174
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0087 0.0115
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0009 0.0017 0.0171
Echinococcus multilocularis Smad4 0.0009 0.0019 0.0016
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0008 0.0005 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Loa Loa (eye worm) blistered cuticle protein 3 0.0078 0.0854 0.1174
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0004 0.0001
Schistosoma mansoni cpg binding protein 0.0037 0.0355 0.0352
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0184 0.0181
Brugia malayi RNA, U transporter 1 0.0099 0.111 0.1526
Brugia malayi hypothetical protein 0.0078 0.0854 0.1174
Brugia malayi glutathione reductase 0.0057 0.0602 0.0826
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0151 0.1764
Schistosoma mansoni nuclear hormone receptor 0.0048 0.049 0.0487
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Onchocerca volvulus 0.0022 0.0177 0.0595
Toxoplasma gondii hypothetical protein 0.0011 0.0041 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.1808 0.6169
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0151 0.0148
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0009 0.0017 0.0078
Echinococcus granulosus cGMP dependent protein kinase 1 0.0008 0.0004 0.0001
Giardia lamblia Sugar-proton symporter 0.0022 0.0177 0.0391
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.015 0.2457
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0022 0.0177 0.0174
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Plasmodium vivax glutathione reductase, putative 0.0057 0.0602 0.0752
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0854 0.1174
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0177 0.0606
Echinococcus granulosus Ankyrin 0.0046 0.0464 0.0461
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0048 0.049 0.1659
Schistosoma mansoni dishevelled 0.0011 0.0041 0.0038
Schistosoma mansoni retinoic acid receptor RXR 0.0048 0.049 0.0487
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0038 0.0372 0.6152
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0088 0.0978 0.0976
Echinococcus granulosus glycyl tRNA synthetase 0.0009 0.0017 0.0014
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.015 0.1754
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0005 0.0028
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0332 0.3924
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0217 0.0294
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0009 0.0017 0.0035
Onchocerca volvulus 0.0078 0.0854 0.2902
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Loa Loa (eye worm) hypothetical protein 0.007 0.076 0.1044
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0151 0.0281
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0045 0.046 0.0457
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0046 0.0721
Onchocerca volvulus 0.0022 0.0177 0.0595
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0062 0.0211
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0798 0.0796
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0008 0.0005 0.0009
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.015 0.185
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Brugia malayi N-terminal motif family protein 0.0218 0.255 0.3513
Loa Loa (eye worm) hypothetical protein 0.0025 0.0217 0.0294
Echinococcus multilocularis lipoxygenase domain containing protein 0.0063 0.0672 0.0669
Echinococcus granulosus nuclear factor of activated T cells 5 0.0232 0.2723 0.2721
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0184 0.0181
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0008 0.0005 0.0009
Echinococcus granulosus acetylcholinesterase 0.007 0.076 0.0757
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0048 0.049 0.0671
Plasmodium falciparum calcium-dependent protein kinase 4 0.0048 0.0492 0.0614
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0225 0.0541
Plasmodium falciparum hexose transporter 0.0157 0.1808 0.2267
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.002
Plasmodium falciparum protein kinase 6 0.0665 0.7965 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.015 0.185
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0022 0.0177 1
Entamoeba histolytica protein kinase, putative 0.0048 0.0492 0.119
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0225 0.1203
Mycobacterium ulcerans sugar transporter 0.0022 0.0177 0.0944
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.0005 0.0002
Echinococcus granulosus solute carrier family 22 0.0022 0.0177 0.0174
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0241 0.2834
Loa Loa (eye worm) hypothetical protein 0.0025 0.0217 0.0294
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.001
Schistosoma mansoni rab6-interacting 0.0063 0.0672 0.0669
Onchocerca volvulus 0.0022 0.0177 0.0595
Brugia malayi tailless protein 0.0023 0.0184 0.0249
Leishmania major hypothetical protein, conserved 0.0008 0.0005 0.0024
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Brugia malayi Sugar transporter family protein 0.0157 0.1808 0.249
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.002
Trichomonas vaginalis spcc417.12 protein, putative 0.0012 0.0054 0.0185
Plasmodium falciparum mitogen-activated protein kinase 2 0.0253 0.2977 0.3735
Brugia malayi hypothetical protein 0.0022 0.0177 0.0241
Leishmania major hypothetical protein, conserved 0.0022 0.0177 0.2193
Leishmania major cytochrome p450-like protein 0.0008 0.0005 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0048 0.049 0.0671
Schistosoma mansoni dep domain containing protein 0.0011 0.0041 0.0038
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0087 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0008 0.0005 0.0009
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0054 0.0277
Schistosoma mansoni thyroid hormone receptor 0.0048 0.049 0.0487
Brugia malayi Cytochrome P450 family protein 0.0008 0.0005 0.0002
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.015 0.0279
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0048 0.0492 0.0614
Mycobacterium ulcerans hypothetical protein 0.0008 0.0005 0.0011
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.015 0.2457
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0008 0.0005 0.0009
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0038 0.0372 0.4392
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0184 0.0181
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0854 0.1174
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0602 0.0599
Entamoeba histolytica hypothetical protein 0.0151 0.1734 0.4214
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.015 0.2457
Echinococcus multilocularis lysyl tRNA synthetase 0.0035 0.0334 0.0331
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0048 0.0492 0.0928
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0602 0.0826
Trypanosoma brucei cytochrome P450, putative 0.0008 0.0005 0.002
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0184 0.0249
Schistosoma mansoni protein kinase 0.0048 0.0492 0.0489
Toxoplasma gondii sugar transporter ST2 0.0022 0.0177 0.0331
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.049 0.0671
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0028 0.0253 0.0607
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0008 0.0005 0.0009
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0048 0.0492 0.5825
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.049 0.0487
Plasmodium vivax proline--tRNA ligase, putative 0.0055 0.0574 0.0717
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0048 0.049 0.0487
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0009 0.0017 0.002
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Plasmodium falciparum lysine--tRNA ligase 0.0035 0.0334 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0299 0.0296
Loa Loa (eye worm) DR-78 0.0023 0.0184 0.0249
Schistosoma mansoni ran 0.0026 0.0221 0.0218
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0151 0.1861
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0157 0.1808 0.1806
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0048 0.049 0.0487
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0854 0.1174
Onchocerca volvulus 0.0063 0.0672 0.2279
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.076 0.0757
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0008 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0299 0.0409
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0019 0.0016
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0008 0.0003 0.0001
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0045 0.046 0.0457
Onchocerca volvulus 0.0012 0.0054 0.0174
Onchocerca volvulus 0.0012 0.0054 0.0174
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0138 0.047
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0854 0.1174
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Leishmania major GTP-binding protein, putative 0.0026 0.0221 0.2739
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0009 0.0017 0.0086
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0854 0.1174
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0815 0.0812
Echinococcus granulosus lysyl tRNA synthetase 0.0035 0.0334 0.0331
Loa Loa (eye worm) hypothetical protein 0.0015 0.0094 0.0125
Loa Loa (eye worm) hypothetical protein 0.0048 0.049 0.0671
Echinococcus granulosus importin subunit beta 1 0.0035 0.0332 0.0329
Brugia malayi hypothetical protein 0.0023 0.0184 0.0249
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0046 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Loa Loa (eye worm) hypothetical protein 0.0026 0.0225 0.0307
Brugia malayi lysyl-tRNA synthetase 0.0035 0.0334 0.0457
Trichomonas vaginalis helicase, putative 0.0008 0.0006 0.002
Entamoeba histolytica hypothetical protein 0.0027 0.0241 0.0579
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0225 0.2795
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0184 0.0249
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0055 0.0051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0217 0.0214
Onchocerca volvulus 0.0022 0.0177 0.0595
Echinococcus granulosus cGMP dependent protein kinase 0.0008 0.0004 0.0001
Trypanosoma brucei glucose transporter, putative 0.0049 0.0499 0.5914
Leishmania major glucose transporter, lmgt1 0.0049 0.0499 0.6238
Brugia malayi Carboxylesterase family protein 0.007 0.076 0.1044
Schistosoma mansoni jun-related protein 0.0072 0.0778 0.0775
Schistosoma mansoni neuroligin 3 (S09 family) 0.0012 0.0054 0.0051
Brugia malayi Importin beta-1 subunit 0.0035 0.0332 0.0454
Plasmodium falciparum glutathione reductase 0.0057 0.0602 0.0752
Echinococcus granulosus intermediate filament protein 0.0033 0.0305 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0062 0.0211
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0048 0.0492 0.0928
Loa Loa (eye worm) major facilitator superfamily transporter 0.0022 0.0177 0.0241
Loa Loa (eye worm) hypothetical protein 0.0047 0.048 0.0658
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0299 0.0562
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0184 0.0249
Echinococcus multilocularis lipoxygenase domain containing protein 0.0063 0.0672 0.0669
Toxoplasma gondii sugar transporter ST1 0.0022 0.0177 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0048 0.049 0.0671
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0241 0.0238
Onchocerca volvulus 0.0008 0.0003 0.0001
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.015 0.0796
Brugia malayi hypothetical protein 0.0011 0.0041 0.0052
Echinococcus granulosus cGMP dependent protein kinase 1 0.0008 0.0004 0.0001
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0038 0.0372 0.0897
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0019 0.0144 0.0195
Schistosoma mansoni lysyl-tRNA synthetase 0.0035 0.0334 0.0331
Onchocerca volvulus 0.0033 0.0305 0.1029
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.0151 0.036
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0009 0.0015 0.0012
Plasmodium falciparum proline--tRNA ligase 0.0055 0.0574 0.0717
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0048 0.0492 0.0489
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1664 0.8986
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0048 0.049 0.0487
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0048 0.049 0.0487
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0009 0.0017 0.002
Trypanosoma cruzi hexose transporter 0.0049 0.0499 0.8283
Echinococcus granulosus cpg binding protein 0.0037 0.0355 0.0352
Echinococcus granulosus carboxylesterase 5A 0.007 0.076 0.0757
Trichomonas vaginalis sugar transport protein, putative 0.0022 0.0177 0.0606
Schistosoma mansoni RAR-like nuclear receptor 0.0048 0.049 0.0487
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4411 0.6079
Leishmania major protein kinase, putative 0.0048 0.0492 0.6144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0046 0.0158
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0008 0.0005 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0225 0.1203
Brugia malayi Peroxidasin 0.0078 0.0854 0.1174
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0041 0.0052
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0138 0.0169
Schistosoma mansoni gliotactin 0.0012 0.0054 0.0051
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0008 0.0005 0.0032
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0798 0.0796
Echinococcus multilocularis snurportin 1 0.0372 0.4411 0.4409
Loa Loa (eye worm) hypothetical protein 0.0048 0.049 0.0671
Mycobacterium leprae Conserved hypothetical protein 0.0008 0.0005 0.001
Brugia malayi major facilitator superfamily protein 0.0022 0.0177 0.0241
Loa Loa (eye worm) hypothetical protein 0.0045 0.046 0.063
Echinococcus multilocularis solute carrier family 22 0.0022 0.0177 0.0174
Echinococcus multilocularis peroxidasin 0.0078 0.0854 0.0851
Loa Loa (eye worm) hypothetical protein 0.0025 0.0217 0.0294
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0046 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.002
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0009 0.0017 0.0035
Schistosoma mansoni ap endonuclease 0.0019 0.0138 0.0135
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0054 0.0051
Echinococcus granulosus peroxidasin 0.0078 0.0854 0.0851
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.002
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0146 0.0179
Echinococcus multilocularis glycyl tRNA synthetase 0.0009 0.0017 0.0014
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0048 0.0492 0.0614
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0006 0.002
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0151 0.0204
Loa Loa (eye worm) hypothetical protein 0.0026 0.0225 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Schistosoma mansoni peroxidasin 0.0078 0.0854 0.0851
Mycobacterium tuberculosis Probable reductase 0.013 0.1488 0.8034
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0035 0.0334 0.3948
Loa Loa (eye worm) hypothetical protein 0.0086 0.0949 0.1305
Loa Loa (eye worm) hypothetical protein 0.0047 0.048 0.0658
Brugia malayi Carboxylesterase family protein 0.0012 0.0054 0.0071
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0241 0.397
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0579 0.0577
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0138 0.047
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.0151 0.2471
Onchocerca volvulus 0.0012 0.0054 0.0174
Loa Loa (eye worm) AGC/PKG protein kinase 0.0008 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0372 0.4411 0.4409
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0253 0.0861
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.015 0.2457
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0038 0.0372 0.0369
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0019 0.0021
Loa Loa (eye worm) CYP4Cod1 0.0008 0.0005 0.0002
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0055 0.0574 0.6809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0046 0.0158
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.0492 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0499 0.1703
Brugia malayi Cytochrome P450 family protein 0.0008 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0305 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0048 0.049 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0499 0.1703
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0047 0.048 0.0658
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0041 0.0038
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0062 0.0111
Echinococcus granulosus BC026374 protein S09 family 0.0012 0.0054 0.0051
Echinococcus multilocularis lamin dm0 0.0033 0.0305 0.0302
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.015 0.0279
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0138 0.2251
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0047 0.048 0.0477
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0151 0.0148
Plasmodium falciparum threonine--tRNA ligase 0.0009 0.0017 0.0018
Plasmodium falciparum glutathione reductase 0.002 0.015 0.0185
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Loa Loa (eye worm) hypothetical protein 0.0032 0.0298 0.0406
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0151 0.1764
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0081
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Plasmodium vivax calcium-dependent protein kinase, putative 0.0048 0.0492 0.0614
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0004 0.0001
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0184 0.0181
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0225 0.1203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0579 0.0577
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0151 0.1764
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Echinococcus multilocularis solute carrier family 22 0.0022 0.0177 0.0174
Echinococcus multilocularis jun protein 0.0088 0.0978 0.0976
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0184 0.0181
Schistosoma mansoni smad1 5 8 and 0.0009 0.0019 0.0016
Schistosoma mansoni protein kinase 0.0048 0.0492 0.0489
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0022 0.0177 0.0174
Trypanosoma cruzi sugar transporter, putative 0.0022 0.0177 0.2912
Brugia malayi hypothetical protein 0.0063 0.0672 0.0922
Giardia lamblia Hexose transporter 0.0022 0.0177 0.0391
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0579 0.0795
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0035 0.0334 0.1994
Giardia lamblia GTOR 0.002 0.0151 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Schistosoma mansoni rab6-interacting 0.0063 0.0672 0.0669
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0008 0.0005 0.0009
Schistosoma mansoni ankyrin 23/unc44 0.0045 0.046 0.0457
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0009 0.0017 0.0078
Loa Loa (eye worm) hypothetical protein 0.0048 0.0492 0.0674
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0012 0.0054 0.0051
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Schistosoma mansoni loxhd1 0.0063 0.0672 0.0669
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.002
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0299 0.0296
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0008 0.0005 0.0028
Onchocerca volvulus Peroxidase homolog 0.0078 0.0854 0.2902
Brugia malayi Egg laying defective protein 4 0.0008 0.0004 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0048 0.049 0.0487
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0184 0.0181
Entamoeba histolytica Ran family GTPase 0.0026 0.0221 0.053
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0046 0.0464 0.0461
Onchocerca volvulus 0.0063 0.0672 0.2279
Schistosoma mansoni thyroid hormone receptor 0.0048 0.049 0.0487
Plasmodium falciparum protein kinase 7 0.0443 0.5272 0.6618
Onchocerca volvulus 0.0069 0.0749 0.2543
Onchocerca volvulus Putative transporter 0.0022 0.0177 0.0595
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.003 0.027 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0046 0.0158
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0041 0.0038
Onchocerca volvulus 0.0012 0.0054 0.0174
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.002
Entamoeba histolytica hypothetical protein 0.0099 0.1106 0.2684
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0008 0.0005 0.0009
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0151 0.2471
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.0492 0.0489
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0225 0.1203
Brugia malayi cytochrome P450 0.0008 0.0005 0.0002
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0184 0.0181
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Echinococcus multilocularis ecdysone induced protein 78C 0.0048 0.049 0.0487
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.015 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0299 0.0296
Echinococcus multilocularis calcium dependent protein kinase 0.0045 0.0456 0.0453
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.0151 0.036
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0225 0.2795
Schistosoma mansoni polycystin 1-related 0.0063 0.0672 0.0669
Echinococcus granulosus calcium dependent protein kinase 0.0045 0.0456 0.0453
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0184 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0579 0.0577
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0184 0.0181
Schistosoma mansoni sugar transporter 0.0022 0.0177 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0177 0.0606
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0035 0.0334 0.1792
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0008 0.0005 0.0009
Toxoplasma gondii lysine-tRNA ligase 0.0035 0.0334 0.0629
Schistosoma mansoni zinc finger protein 0.0023 0.0184 0.0181
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0029 0.0026
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0009 0.0015 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Schistosoma mansoni hypothetical protein 0.0008 0.0005 0.0002
Echinococcus multilocularis acetylcholinesterase 0.007 0.076 0.0757
Schistosoma mansoni hypothetical protein 0.0045 0.046 0.0457
Brugia malayi hypothetical protein 0.0063 0.0672 0.0922
Schistosoma mansoni hypothetical protein 0.0205 0.2388 0.2386
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0048 0.049 0.0671
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0184 0.0249
Trypanosoma cruzi hypothetical protein 0.0008 0.0003 0.0004
Trypanosoma brucei glucose transporter 2A 0.0049 0.0499 0.5914
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0602 0.3241
Plasmodium falciparum calcium-dependent protein kinase 5 0.0048 0.0492 0.0614
Loa Loa (eye worm) hypothetical protein 0.0023 0.0195 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Onchocerca volvulus Chorion peroxidase homolog 0.0078 0.0854 0.2902
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0008 0.0005 0.0009
Loa Loa (eye worm) major facilitator superfamily transporter 0.0022 0.0177 0.0241
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0197
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0152 0.1866
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Schistosoma mansoni glycyl-tRNA synthetase 0.0009 0.0017 0.0014
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0157 0.1808 0.1806
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0048 0.049 0.0671
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0195 0.3198
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0225 0.1203
Toxoplasma gondii glycyl-tRNA synthetase 0.0009 0.0017 0.0027
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Brugia malayi Protein kinase domain containing protein 0.0048 0.0496 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0009 0.0017 0.002
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Echinococcus granulosus lipoxygenase domain containing protein 0.0063 0.0672 0.0669
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.015 0.2457
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.001 0.0027 0.0281
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0047 0.048 0.1637
Schistosoma mansoni lipoxygenase 0.0125 0.1422 0.1419
Brugia malayi nuclear receptor NHR-88 0.0048 0.049 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0133 0.0703
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.015 0.2457
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0225 0.0541
Loa Loa (eye worm) doublecortin family protein 0.0063 0.0672 0.0922
Echinococcus multilocularis cpg binding protein 0.0037 0.0355 0.0352
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0052
Plasmodium falciparum calcium-dependent protein kinase 3 0.0048 0.0492 0.0614
Trypanosoma cruzi hexose transporter, putative 0.0022 0.0177 0.2912
Trichomonas vaginalis glutathione reductase, putative 0.002 0.015 0.0513
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.015 0.0147
Onchocerca volvulus 0.0023 0.0184 0.0616
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.002
Loa Loa (eye worm) carboxylesterase 0.0012 0.0054 0.0071
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0225 0.1203
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0008 0.0005 0.0009
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0138 0.1695
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0151 0.1861
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0048 0.049 0.0671
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0602 0.0752
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0579 0.0577
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0221 0.3638
Echinococcus granulosus acetylcholinesterase 0.007 0.076 0.0757
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.003 0.027 0.161
Trichomonas vaginalis mercuric reductase, putative 0.002 0.015 0.0513
Brugia malayi hypothetical protein 0.0069 0.0749 0.1029
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0184 0.0181
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0041 0.0128
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0019 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Leishmania major threonyl-tRNA synthetase, putative 0.0009 0.0017 0.0181
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0048 0.0492 0.0674
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0101 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0046 0.0158
Trypanosoma cruzi hexose transporter, putative 0.0027 0.0232 0.3828
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.003 0.027 0.1447
Onchocerca volvulus 0.0022 0.0177 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0157 0.1808 0.1806
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0157 0.1808 0.1806
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0055 0.0574 0.7182
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Loa Loa (eye worm) hypothetical protein 0.0048 0.049 0.0671
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0052
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0602 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0151 0.1764
Brugia malayi nuclear hormone receptor 0.0048 0.049 0.0671
Chlamydia trachomatis proline--tRNA ligase 0.0017 0.0112 0.2978
Trypanosoma brucei sugar transporter, putative 0.0022 0.0177 0.2079
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0138 0.7525
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.015 0.0147
Trypanosoma brucei glucose transporter, putative 0.0049 0.0499 0.5914
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0009 0.0017 0.0059
Loa Loa (eye worm) carboxylesterase 0.007 0.076 0.1044
Schistosoma mansoni ran 0.0026 0.0221 0.0218
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1488 0.8034
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0035 0.0334 0.5529
Schistosoma mansoni intermediate filament proteins 0.0033 0.0305 0.0302
Leishmania major protein kinase, putative 0.0008 0.0004 0.0011
Loa Loa (eye worm) acetylcholinesterase 1 0.007 0.076 0.1044
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0152 0.2479
Entamoeba histolytica hypothetical protein 0.0035 0.0334 0.0806
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0005 0.0017
Leishmania major trypanothione reductase 0.0057 0.0602 0.753
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Onchocerca volvulus 0.0032 0.0299 0.101
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0217 0.0214
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0041 0.0038
Trichomonas vaginalis glucose transporter, putative 0.0049 0.0499 0.1703
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0019 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0048 0.049 0.0671
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.015 0.2457
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0157 0.1808 0.1806
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0138 0.0328
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0048 0.049 0.0487
Schistosoma mansoni nuclear receptor 0.0023 0.0184 0.0181
Brugia malayi MH2 domain containing protein 0.0009 0.0019 0.0021
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.015 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0015 0.0053
Loa Loa (eye worm) sugar transporter 0.0022 0.0177 0.0241
Schistosoma mansoni sugar transporter 0.0022 0.0177 0.0174
Schistosoma mansoni hypothetical protein 0.0494 0.5891 0.589
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0177 0.0606
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.0151 0.2471
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0101 0.0098
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Echinococcus multilocularis 0.0008 0.0005 0.0002
Trichomonas vaginalis myo-inositol transporter, putative 0.0022 0.0177 0.0606
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0022 0.0177 0.2079
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0048 0.049 0.0487
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0332 0.0329
Entamoeba histolytica hypothetical protein 0.0151 0.1734 0.4214
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Schistosoma mansoni peroxidasin 0.0078 0.0854 0.0851
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0184 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0005 0.0017
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0184 0.0181
Schistosoma mansoni lipoxygenase 0.0238 0.2792 0.2789
Echinococcus granulosus General substrate transporter 0.0135 0.1541 0.1539
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0019 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0798 0.4304
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0047 0.048 0.0658
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0035 0.0334 0.1792
Onchocerca volvulus 0.0012 0.0054 0.0174
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0046 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0008 0.0005 0.0009
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0241 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0055 0.0574 0.9538
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.2566 0.3534
Schistosoma mansoni glucose transporter 0.0022 0.0177 0.0174
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0009 0.0017 0.0078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0006 0.002
Plasmodium falciparum cGMP-dependent protein kinase 0.0008 0.0004 0.0001
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0038 0.0372 0.4633
Toxoplasma gondii protein kinase, putative 0.0443 0.5272 1
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.046 0.063
Brugia malayi MH2 domain containing protein 0.0009 0.0019 0.0021
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0005 0.0028
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Echinococcus granulosus synaptic vesicle 2 protein 0.0022 0.0177 0.0174
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0299 0.0296
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0038 0.0372 0.0463
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0017 0.0112 0.0588
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0217 0.0294
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0258 0.0352
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0046 0.006
Onchocerca volvulus 0.0022 0.0177 0.0595
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.015 0.0185
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0048 0.049 0.0487
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0047 0.048 0.1161
Brugia malayi MH1 domain containing protein 0.0009 0.0019 0.0021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0008 0.0005 0.0011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0602 0.0599
Loa Loa (eye worm) hypothetical protein 0.007 0.076 0.1044
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0022 0.0177 0.0944
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.0607 0.7254 1
Leishmania major glucose transporter, lmgt3 0.0049 0.0499 0.6238
Plasmodium falciparum LCCL domain-containing protein 0.0063 0.0672 0.084
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.015 0.8297
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0138 0.0186
Brugia malayi hypothetical protein 0.0023 0.0184 0.0249
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0038 0.0372 0.0508
Schistosoma mansoni transcription factor LCR-F1 0.0151 0.1734 0.1731
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1488 0.8034
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0048 0.049 0.0671
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0225 0.1203
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0221 0.0274
Leishmania major myo-inositol/proton symporter (MIT) 0.0022 0.0177 0.2193
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0008 0.0005 0.0009
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0088 0.0978 0.0976
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Loa Loa (eye worm) hypothetical protein 0.0015 0.0094 0.0125
Trichomonas vaginalis glucose transporter, putative 0.0049 0.0499 0.1703
Schistosoma mansoni lamin 0.0033 0.0305 0.0302
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0008 0.0005 0.0009
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0053 0.0069
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0232 0.2723 0.2721
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0138 0.0186
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0798 0.4304
Brugia malayi Pre-SET motif family protein 0.0219 0.2566 0.3534
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0048 0.049 0.0487
Brugia malayi hypothetical protein 0.0025 0.0217 0.0294
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0048 0.049 0.0487
Schistosoma mansoni hypothetical protein 0.0151 0.1734 0.1731
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0008 0.0005 0.0009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0055 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.049 0.0487
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0305 0.0416
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0151 0.0204
Brugia malayi Major Facilitator Superfamily protein 0.0022 0.0177 0.0241
Mycobacterium tuberculosis Carboxylesterase LipT 0.0012 0.0054 0.0277
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0019 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0225 0.0541
Schistosoma mansoni importin beta-1 0.0035 0.0332 0.0329
Onchocerca volvulus Peroxidase homolog 0.0078 0.0854 0.2902
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0041 0.0038
Toxoplasma gondii thioredoxin reductase 0.0057 0.0602 0.1137
Leishmania major lysyl-tRNA synthetase, putative 0.0035 0.0334 0.4164
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0332 0.0625
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0184 0.0181
Echinococcus multilocularis solute carrier family 22 0.0022 0.0177 0.0174
Brugia malayi Sugar transporter family protein 0.0022 0.0177 0.0241
Toxoplasma gondii sugar transporter ST3 0.0022 0.0177 0.0331
Plasmodium vivax SET domain protein, putative 0.0032 0.0299 0.0372
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0008 0.0005 0.0009
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0008 0.0005 0.0009
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0012 0.0054 0.0051
Trypanosoma brucei glucose transporter, putative 0.0049 0.0499 0.5914
Onchocerca volvulus 0.025 0.2936 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0048 0.049 0.0671
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0008 0.0004 0.0002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0138 0.0135
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0151 0.2471
Brugia malayi MH2 domain containing protein 0.0131 0.1495 0.2058
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0197
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0225 0.0307
Trypanosoma brucei trypanothione reductase 0.0057 0.0602 0.7139
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0054 0.0051
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0008 0.0005 0.0009
Chlamydia trachomatis lysine--tRNA ligase 0.0035 0.0334 1
Brugia malayi nuclear receptor RXR 0.0023 0.0184 0.0249
Echinococcus granulosus lamin 0.0033 0.0305 0.0302
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Brugia malayi hypothetical protein 0.0012 0.0054 0.0071
Treponema pallidum NADH oxidase 0.002 0.015 1
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0048 0.049 0.0487
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0008 0.0005 0.0009
Schistosoma mansoni sugar transporter 0.0022 0.0177 0.0174
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0221 0.2597
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0138 0.0294
Echinococcus multilocularis smad 0.0009 0.0019 0.0016
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0122 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Echinococcus granulosus Threonyl tRNA synthetase C 0.0009 0.0017 0.0014
Brugia malayi hypothetical protein 0.0022 0.0177 0.0241
Schistosoma mansoni smad1 5 8 and 0.0009 0.0019 0.0016
Brugia malayi Cam kinase protein 1 0.0048 0.0492 0.0674
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0008 0.0005 0.0009
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0184 0.0616
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0009 0.0017 0.024
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0099 0.1106 0.2684
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0008 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0048 0.049 0.0671
Brugia malayi Carboxylesterase family protein 0.007 0.076 0.1044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0133 0.0703
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0048 0.0492 0.0928
Brugia malayi Cytochrome P450 family protein 0.0029 0.0258 0.0352
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0299 0.0296
Echinococcus multilocularis BC026374 protein (S09 family) 0.0012 0.0054 0.0051
Trypanosoma brucei glucose transporter, putative 0.0049 0.0499 0.5914
Brugia malayi major facilitator superfamily protein 0.0022 0.0177 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0048 0.049 0.0671
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0008 0.0005 0.0004
Onchocerca volvulus 0.0078 0.0854 0.2902
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0008 0.0005 0.0009
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.015 0.2457
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.002
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0047 0.048 0.0477
Onchocerca volvulus 0.0022 0.0177 0.0595
Mycobacterium ulcerans lipoprotein LpqF 0.0077 0.0842 0.454
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0221 0.0274
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0253 0.0861
Echinococcus multilocularis geminin 0.0205 0.2388 0.2386
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.015 0.185
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0151 0.0148
Trichomonas vaginalis ran, putative 0.0026 0.0221 0.0754
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0579 0.0577
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0008 0.0005 0.0009
Mycobacterium ulcerans hypothetical protein 0.0026 0.0225 0.1203
Onchocerca volvulus 0.0022 0.0177 0.0595
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0146 0.0772
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0038 0.0372 0.0508
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0184 0.0181
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0253 0.0861
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Loa Loa (eye worm) hypothetical protein 0.0025 0.0217 0.0294
Trypanosoma brucei THT1 - hexose transporter, putative 0.0049 0.0499 0.5914
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0048 0.049 0.0671
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0012 0.0054 0.0185
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0241 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0046 0.0158
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0009 0.0017 0.0014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.015 0.0796
Brugia malayi Uncoordinated protein 44 0.0045 0.046 0.063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0048 0.049 0.0671
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0041 0.0038
Onchocerca volvulus Peroxidasin homolog 0.0078 0.0854 0.2902
Schistosoma mansoni hypothetical protein 0.0009 0.0015 0.0012
Echinococcus granulosus neuroligin 0.0012 0.0054 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Echinococcus granulosus Sugar transporter ERD6 protein 0.0022 0.0177 0.0174
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0008 0.0004 0.0001
Onchocerca volvulus 0.0022 0.0177 0.0595
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0184 0.0249
Plasmodium falciparum thioredoxin reductase 0.002 0.015 0.0185
Schistosoma mansoni glucose transport protein 0.0157 0.1808 0.1806
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0077 0.0842 0.454
Onchocerca volvulus 0.0022 0.0177 0.0595
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0005 0.0028
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0055 0.0574 0.1084
Schistosoma mansoni nuclear receptor 0.0023 0.0184 0.0181
Schistosoma mansoni cpg binding protein 0.0037 0.0355 0.0352
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0184 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0798 0.0796
Onchocerca volvulus 0.0022 0.0177 0.0595
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0151 0.0148
Onchocerca volvulus Dual oxidase homolog 0.0078 0.0854 0.2902
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0077 0.0842 0.5052
Onchocerca volvulus 0.0011 0.0041 0.0128
Trypanosoma cruzi hypothetical protein 0.0008 0.0003 0.0004
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0038 0.0372 0.0463
Plasmodium vivax glycine--tRNA ligase, putative 0.0009 0.0017 0.0018
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0035 0.0334 0.114
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0041 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Onchocerca volvulus Netrin receptor homolog 0.0045 0.046 0.1557
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.002
Schistosoma mansoni glucose transport protein 0.0157 0.1808 0.1806
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0048 0.049 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Plasmodium falciparum importin beta, putative 0.0035 0.0332 0.0413
Brugia malayi nuclear hormone receptor 0.0023 0.0184 0.0249
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0184 0.0249
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0029 0.0026
Echinococcus multilocularis solute carrier family 22 0.0022 0.0177 0.0174
Brugia malayi bZIP transcription factor family protein 0.0088 0.0978 0.1345
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0225 0.1339
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0854 0.1174
Schistosoma mansoni coup transcription factor 0.0048 0.049 0.0487
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0009 0.0017 0.002
Schistosoma mansoni smad1 5 8 and 0.0009 0.0019 0.0016
Onchocerca volvulus 0.0022 0.0177 0.0595
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0151 0.2471
Trypanosoma cruzi hexose transporter, putative 0.0049 0.0499 0.8283
Schistosoma mansoni hypothetical protein 0.0205 0.2388 0.2386
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0331 0.0452
Brugia malayi MH1 domain containing protein 0.0009 0.0019 0.0021
Echinococcus granulosus snurportin 1 0.0372 0.4411 0.4409
Brugia malayi nuclear receptor NHR-88 0.0023 0.0184 0.0249
Onchocerca volvulus 0.0048 0.049 0.1659
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0151 0.1861
Plasmodium falciparum calcium-dependent protein kinase 1 0.0048 0.0492 0.0614
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0048 0.0492 0.0674
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0138 0.907
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0299 0.0296
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0253 0.2977 0.3735
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5891 0.589
Toxoplasma gondii facilitative glucose transporter GT1 0.0157 0.1808 0.3426
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0008 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0078 0.0854 0.1174
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0184 0.0249
Loa Loa (eye worm) carboxylesterase 0.0012 0.0054 0.0071
Loa Loa (eye worm) steroid hormone receptor 0.0048 0.049 0.0671
Mycobacterium leprae conserved hypothetical protein 0.0008 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0071
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0217 0.0214
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1664 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0038 0.0372 0.1267
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0009 0.0017 0.0027
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0038 0.0372 0.6152
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0045 0.046 0.063
Entamoeba histolytica hypothetical protein 0.0151 0.1734 0.4214
Brugia malayi hypothetical protein 0.0025 0.0217 0.0294
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0138 0.0135
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0038 0.0372 0.0508
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0041 0.0038
Schistosoma mansoni netrin receptor unc5 0.0045 0.046 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0492 0.0489
Trichomonas vaginalis set domain proteins, putative 0.0249 0.2931 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0253 0.2977 0.5644
Brugia malayi photoreceptor-specific nuclear receptor 0.0048 0.049 0.0671
Brugia malayi nuclear receptor RXR 0.0025 0.0217 0.0294
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0046 0.0105
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0146 0.0179
Toxoplasma gondii exonuclease III APE 0.0019 0.0138 0.0256
Onchocerca volvulus 0.0023 0.0184 0.0616
Echinococcus granulosus Polycystic kidney disease protein 0.0063 0.0672 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Echinococcus granulosus Smad4 0.0009 0.0019 0.0016
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0332 0.3924
Trypanosoma cruzi glucose transporter, putative 0.0022 0.0177 0.2912
Loa Loa (eye worm) hypothetical protein 0.0026 0.0225 0.0307
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0133 0.0703
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0008 0.0005 0.0009
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0008 0.0005 0.0009
Schistosoma mansoni cytochrome P450 0.0008 0.0005 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0225 0.1203
Echinococcus multilocularis netrin receptor unc 5 0.0045 0.046 0.0457
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0038 0.0372 0.0508
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0022 0.0177 0.0944
Echinococcus multilocularis Polycystic kidney disease protein 0.0063 0.0672 0.0669
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.0492 0.0489
Schistosoma mansoni steroid hormone receptor ad4bp 0.0048 0.049 0.0487
Trypanosoma brucei glucose transporter, putative 0.0049 0.0499 0.5914
Brugia malayi CXXC zinc finger family protein 0.0035 0.0331 0.0452
Schistosoma mansoni protein kinase 0.0048 0.0492 0.0489
Brugia malayi Smad1 0.0009 0.0019 0.0021
Schistosoma mansoni hypothetical protein 0.0063 0.0672 0.0669
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0008 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0238 0.2792 0.2789
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Brugia malayi Sugar transporter family protein 0.0022 0.0177 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0122 0.0164
Onchocerca volvulus 0.0078 0.0854 0.2902
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0579 0.0577
Trypanosoma cruzi hexose transporter, putative 0.0049 0.0499 0.8283
Loa Loa (eye worm) hypothetical protein 0.0035 0.0332 0.0454
Echinococcus multilocularis carboxylesterase 5A 0.007 0.076 0.0757
Entamoeba histolytica protein kinase, putative 0.0048 0.0492 0.119
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0041 0.0052
Onchocerca volvulus 0.0022 0.0177 0.0595
Mycobacterium ulcerans carboxylesterase, LipT 0.0012 0.0054 0.0277
Schistosoma mansoni lamin 0.0033 0.0305 0.0302
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0798 0.4304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0046 0.0158
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1488 0.8034
Onchocerca volvulus 0.0022 0.0177 0.0595
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Echinococcus multilocularis FTZ F1 alpha 0.0048 0.049 0.0487
Plasmodium falciparum calcium-dependent protein kinase 2 0.0048 0.0492 0.0614
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0009 0.0017 0.0171
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0347 0.4111 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0672 0.0922
Trypanosoma brucei glucose transporter, putative 0.0049 0.0499 0.5914
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0221 0.3638
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.015 0.0185
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0151 0.0204
Toxoplasma gondii cytochrome p450 superfamily protein 0.0008 0.0005 0.0003
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0041 0.0052
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0854 0.1174
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.015 0.2457
Schistosoma mansoni Smad4 0.0009 0.0019 0.0016
Echinococcus granulosus lipoxygenase domain containing protein 0.0063 0.0672 0.0669
Brugia malayi nuclear receptor NHR-67 0.0023 0.0184 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0048 0.049 0.0671
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0041 0.0038
Echinococcus multilocularis RUN 0.0063 0.0672 0.0669
Giardia lamblia Prolyl-tRNA synthetase 0.0047 0.048 0.113
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0177 0.0606
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0184 0.0249
Loa Loa (eye worm) hypothetical protein 0.0035 0.0334 0.0457
Plasmodium vivax threonine--tRNA ligase, putative 0.0009 0.0017 0.0018
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0151 0.0148
Schistosoma mansoni cpg binding protein 0.0035 0.0331 0.0328
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0138 0.0169
Echinococcus granulosus para nitrobenzyl esterase 0.0012 0.0054 0.0051
Brugia malayi Major Facilitator Superfamily protein 0.0022 0.0177 0.0241
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0157 0.1808 0.1806
Mycobacterium leprae putative cytochrome p450 0.0008 0.0005 0.001
Brugia malayi Thioredoxin reductase 0.0057 0.0602 0.0826
Plasmodium falciparum thioredoxin reductase 0.0057 0.0602 0.0752
Schistosoma mansoni hypothetical protein 0.0072 0.0778 0.0775
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0146 0.0772
Onchocerca volvulus 0.0022 0.0177 0.0595
Trypanosoma brucei glucose transporter 1E 0.0049 0.0499 0.5914
Brugia malayi intermediate filament protein 0.0033 0.0305 0.0416
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0798 0.0796
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0038 0.0372 0.1267
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.002
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0008 0.0005 0.0021
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1664 0.8986
Echinococcus multilocularis neuroligin 0.0012 0.0054 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0133 0.0703
Leishmania major glucose transporter, lmgt2 0.0049 0.0499 0.6238
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0038 0.0372 0.0699
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0055 0.0574 0.9538
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0048 0.049 0.0487
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0008 0.0005 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Leishmania major cytochrome p450-like protein 0.0008 0.0005 0.0021
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0038 0.0372 0.0369
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0221 0.0218
Echinococcus multilocularis Ankyrin 0.0046 0.0464 0.0461
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0055 0.0574 0.7182
Brugia malayi Death domain containing protein 0.0045 0.046 0.063
Onchocerca volvulus 0.0022 0.0177 0.0595
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0008 0.0005 0.0032
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0854 0.1174
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Brugia malayi small heat shock protein 0.0607 0.7254 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0197
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.015 0.0796
Brugia malayi FAT domain containing protein 0.0009 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0249
Brugia malayi ecdysone receptor 0.0023 0.0184 0.0249
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0221 0.0414
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0798 0.4304
Onchocerca volvulus 0.0035 0.0331 0.1117
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0019 0.0016
Toxoplasma gondii transporter, major facilitator family protein 0.0022 0.0177 0.0331
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0299 0.0296
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.049 0.0487
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1488 0.8034
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0008 0.0004 0.0001
Brugia malayi DIX domain containing protein 0.0011 0.0041 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0184 0.0249
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1495 0.2058
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.015 0.1754
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.006
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0217 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0048 0.049 0.0671
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0008 0.0005 0.0009
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.015 0.4192
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0798 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0008 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0197
Onchocerca volvulus 0.0026 0.0225 0.0758
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0157 0.1808 0.1806
Plasmodium vivax CDK-related protein kinase 6, putative 0.0665 0.7965 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0008 0.0005 0.0009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0048 0.049 0.0487
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0008 0.0003 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0022 0.0177 0.0606
Leishmania major protein kinase, putative 0.0008 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0241
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0217 0.0294
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0047 0.048 0.0477
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0151 0.1861
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1488 0.8034
Brugia malayi Steroid receptor seven-up type 2 0.0048 0.049 0.0671
Leishmania major importin beta-1 subunit, putative 0.0028 0.0253 0.3136
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0048 0.0492 0.0614
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0225 0.2795
Treponema pallidum prolyl-tRNA synthetase 0.0017 0.0112 0.7103
Schistosoma mansoni dishevelled 0.0011 0.0041 0.0038
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.016 0.1851 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0041 0.0052
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0151 0.1734 0.1731
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0008 0.0005 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0151 0.0515
Echinococcus multilocularis expressed conserved protein 0.0008 0.0004 0.0001
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0008 0.0005 0.0009
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0022 0.0177 0.0944
Brugia malayi Carboxylesterase family protein 0.0012 0.0054 0.0071
Giardia lamblia Lysyl-tRNA synthetase 0.0035 0.0334 0.0774
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0146 0.4052
Brugia malayi glycyl-tRNA synthetase 0.0009 0.0017 0.002
Echinococcus multilocularis para nitrobenzyl esterase 0.0012 0.0054 0.0051
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0047 0.048 0.2872
Brugia malayi hypothetical protein 0.0022 0.0177 0.0241

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.035 uM PubChem BioAssay. FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify epi-absorbance assay artifacts. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 12.922 uM PubChem BioAssay. Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 22 uM Inhibition of partially purified Fischer-344 rat lens ALR2 using D,L-glyceraldehyde as substrate assessed as NADPH consumption by spectrophotometry ChEMBL. 23891165
IC50 (binding) > 59.64 uM PubChem BioAssay. Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of TEM-1 serine-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 59.64 uM PubChem BioAssay. FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 59.64 uM PubChem BioAssay. Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 100 uM Inhibition of partially purified Fischer-344 rat kidney ALR1 using D,L-glycuronate as substrate assessed as NADPH consumption by spectrophotometry ChEMBL. 23891165
Inhibition (binding) = 36 % In vitro inhibitory activity against aldose reductase of rat lens at 10E-5 M concentration ChEMBL. 12540241
Inhibition (binding) = 36 % In vitro inhibitory activity against aldose reductase of rat lens at 10E-5 M concentration ChEMBL. 12540241
Potency (functional) 0.0586 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 2.0596 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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