Detailed information for compound 36109

Basic information

Technical information
  • TDR Targets ID: 36109
  • Name: 2-phenylbenzo[h]chromen-4-one
  • MW: 272.297 | Formula: C19H12O2
  • H donors: 0 H acceptors: 1 LogP: 4.43 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(oc2c1ccc1c2cccc1)c1ccccc1
  • InChi: 1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H
  • InChiKey: VFMMPHCGEFXGIP-UHFFFAOYSA-N  


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Synonyms

  • 2-phenyl-4-benzo[h][1]benzopyranone
  • alpha-naphthoflavone
  • 2-phenyl-4-benzo[h]chromenone
  • 604-59-1
  • Oprea1_802803
  • ZINC00038933
  • NCGC00017210-01
  • TNP00080
  • .alpha.-Naphthoflavone
  • .alpha.-Naphthylflavone
  • 4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl-
  • N5757_SIGMA
  • NCGC00142408-01
  • 7,8-Benzoflavone
  • Oprea1_054595
  • AIDS-105039
  • NSC407011
  • Benzo(h)flavone
  • 2-Phenyl-4H-naphtho(1,2-b)pyran-4-one
  • 2-Phenylbenzo(h)chromen-4-one
  • 4H-NAPHTHO(1,2-b)PYRAN-4-ONE, 2-PHENYL-
  • 5-17-10-00726 (Beilstein Handbook Reference)
  • 7,8-BF
  • 7,8-Benzoflavone (7CI)
  • BRN 0210862
  • ST055359
  • CCRIS 3607
  • EINECS 210-071-1
  • NSC 407011
  • alpha-Naphthylflavone
  • 2-Phenyl-benzo[h]chromen-4-one
  • BAS 07630283
  • BHF
  • AIDS105039

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Starlite/ChEMBL References
Homo sapiens protein kinase, DNA-activated, catalytic polypeptide Starlite/ChEMBL References
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens phosphodiesterase 5A, cGMP-specific Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 Starlite/ChEMBL References
Homo sapiens adenosine A1 receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 1, subfamily B, polypeptide 1 Starlite/ChEMBL References
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily B, polypeptide 6 Starlite/ChEMBL References
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Rattus norvegicus Adenosine A2a receptor Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens tachykinin receptor 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 Starlite/ChEMBL References
Homo sapiens thromboxane A synthase 1 (platelet) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ATP-binding cassette sub-family G member 1, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) multidrug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma japonicum ko:K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi multidrug resistance protein E, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania infantum ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Giardia lamblia ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis ABC transporter protein Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei multidrug resistance protein E Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium knowlesi ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium parvum ATP-binding cassette protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma congolense multidrug resistance protein A Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense multidrug resistance protein E,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Brugia malayi multidrug resistance related protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum ABC transporter, AAA domain Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania braziliensis p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium falciparum ABC transporter G family member 2 Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Giardia lamblia ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Neospora caninum hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium berghei ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Entamoeba histolytica multidrug resistance protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense multidrug resistance-associated protein, putative,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium vivax ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia MRP-like ABC transporter Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum ko:K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Canalicular multispecific organic anion transporter 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania infantum ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania infantum ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium hominis SI:dZ52I16.4 (novel ABC transporter similar to human multidrug-resistance proteins (MRP)) Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Cryptosporidium parvum ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter, ATP-binding protein domain containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi ABC transporter family protein Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Multidrug resistance-associated protein 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 7, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum ko:K05681 ATP-binding cassette, subfamily G (WHITE), member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana multidrug resistance protein, copy 1-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania infantum ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Trypanosoma cruzi cytochrome P450, putative cytochrome P450, family 19, subfamily A, polypeptide 1 503 aa 425 aa 18.8 %
Trypanosoma brucei ABC transporter, putative ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 611 aa 557 aa 28.2 %
Echinococcus granulosus allatostatin A receptor Adenosine A2a receptor   410 aa 368 aa 22.6 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 317 aa 24.6 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 286 aa 26.9 %
Trypanosoma brucei cytochrome P450, putative thromboxane A synthase 1 (platelet) 534 aa 498 aa 21.5 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 327 aa 24.8 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 274 aa 22.6 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 311 aa 21.2 %
Echinococcus multilocularis allatostatin A receptor Adenosine A2a receptor   410 aa 372 aa 22.8 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A2a receptor   410 aa 352 aa 23.6 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 306 aa 21.2 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2a receptor   410 aa 399 aa 28.1 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2a receptor   410 aa 366 aa 25.4 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 1 512 aa 505 aa 26.7 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2a receptor   410 aa 340 aa 27.9 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2a receptor   410 aa 346 aa 28.3 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 356 aa 23.9 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 304 aa 21.1 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.9 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily B, polypeptide 6 491 aa 395 aa 19.5 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 337 aa 23.1 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 323 aa 20.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0043 0.0144 0.0182
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0044 0.0044
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.013 0.0263
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0156 0.063 0.0797
Brugia malayi hypothetical protein 0.0118 0.0466 0.072
Loa Loa (eye worm) hypothetical protein 0.0119 0.047 0.047
Onchocerca volvulus 0.0039 0.013 0.0992
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0048 0.0073
Brugia malayi hypothetical protein 0.0019 0.0043 0.0067
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0009 0 0.0001
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.0084 0.0319 0.0319
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0077 0.0155
Schistosoma mansoni multidrug resistance protein 0.0017 0.0036 0.0055
Brugia malayi hypothetical protein 0.0015 0.0026 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0055 0.0085
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.049 0.099
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Echinococcus granulosus jun protein 0.0101 0.0395 0.0798
Brugia malayi hypothetical protein 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0084 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0044 0.015 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0104 0.0132
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0048 0.0073
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit 0.0065 0.024 0.0484
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Leishmania major protein kinase, putative 0.002 0.0046 0.0057
Brugia malayi Cytochrome P450 family protein 0.0112 0.044 0.0679
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0048 0.0096
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0112 0.0646
Brugia malayi Uncoordinated protein 44 0.002 0.0046 0.0071
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0017 0.0036 0.0045
Brugia malayi larval opioid receptor 0.002 0.0048 0.0073
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0044 0.0259
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0244 0.1004 0.155
Loa Loa (eye worm) DR-78 0.0039 0.013 0.013
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0055 0.0055
Schistosoma mansoni amine GPCR 0.002 0.0048 0.0073
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0036 0.157
Onchocerca volvulus 0.0118 0.0466 0.3812
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.002 0.0041
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0156 0.0315
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0203 0.0828 0.1671
Giardia lamblia MRP-like ABC transporter 0.0017 0.0036 0.157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0084 0.0319 0.0493
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.013 0.013
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0048 0.0096
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0314 0.0485
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0244 0.1004 0.155
Echinococcus multilocularis 0.0043 0.0144 0.0291
Loa Loa (eye worm) hypothetical protein 0.0084 0.0319 0.0319
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0062 0.0224
Loa Loa (eye worm) hypothetical protein 0.0099 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0044 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0112 0.0141
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0118 0.0466 0.0941
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0163 0.0206
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0015 0.0026 0.0052
Schistosoma mansoni neurotransmitter gated ion channel 0.0118 0.0466 0.072
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Brugia malayi hypothetical protein 0.002 0.0048 0.0073
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0048 0.0073
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.0277 0.035
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0015 0.0026 0.0032
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Schistosoma mansoni nuclear hormone receptor 0.0039 0.013 0.0201
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0073
Plasmodium falciparum dihydroorotate dehydrogenase 0.04 0.1672 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0244 0.1004 0.2026
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.002 0.0046 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0048 0.0073
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.002 0.0094
Schistosoma mansoni ap endonuclease 0.0019 0.0044 0.0068
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Onchocerca volvulus 0.0035 0.0112 0.0839
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0118 0.0466 0.072
Schistosoma mansoni multidrug resistance protein 0.0017 0.0036 0.0055
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0156 0.0315
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0084 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.002 0.0026
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0017 0.0036 0.0045
Onchocerca volvulus 0.002 0.0048 0.0299
Leishmania major cytochrome p450-like protein 0.0043 0.0144 0.0182
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0535 0.1081
Echinococcus multilocularis stromal interaction molecule 1 0.0015 0.0026 0.0052
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.0535 0.0827
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0084 0.0319 0.0493
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0043 0.0144 0.0791
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.013 0.0263
Trypanosoma brucei DNA repair protein, putative 0.0023 0.0058 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0043 0.0144 0.084
Brugia malayi steroid hormone receptor 0.0084 0.0319 0.0493
Onchocerca volvulus 0.002 0.0048 0.0299
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0248 0.1021 0.1578
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0211 0.0325
Onchocerca volvulus 0.0118 0.0466 0.3812
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0009 0 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0084 0.0319 0.0493
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0244 0.1004 0.1004
Mycobacterium ulcerans hypothetical protein 0.0024 0.0065 0.0313
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0039 0.0155
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0009 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0012 0.0014 0.0018
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0277 0.035
Loa Loa (eye worm) hypothetical protein 0.0134 0.0535 0.0535
Brugia malayi hypothetical protein 0.0044 0.015 0.0232
Plasmodium falciparum heterochromatin protein 1 0.0014 0.002 0.012
Brugia malayi CHD4 protein 0.0014 0.002 0.0032
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0535 0.0827
Entamoeba histolytica hypothetical protein 0.0043 0.0147 0.1692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0048 0.0096
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0062 0.0295
Brugia malayi Cytochrome P450 family protein 0.0053 0.019 0.0293
Onchocerca volvulus 0.0014 0.002 0.0072
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0048 0.0096
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0112 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.002 0.0026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0128 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) helicase 0.0014 0.002 0.002
Trichomonas vaginalis guanylate cyclase, putative 0.0019 0.0043 0.0054
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0277 0.035
Brugia malayi beta-lactamase 0.0035 0.0112 0.0173
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4148 0.8373
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0063 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0048 0.0096
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0055 0.0069
Echinococcus multilocularis chromobox protein 2 0.0014 0.002 0.0041
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.049 0.0758
Echinococcus granulosus death domain containing protein 0.0017 0.0036 0.0072
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0048 0.0096
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0043 0.0144 0.0791
Entamoeba histolytica hypothetical protein 0.0037 0.012 0.1345
Schistosoma mansoni coup transcription factor 0.0084 0.0319 0.0493
Loa Loa (eye worm) hypothetical protein 0.0044 0.015 0.015
Loa Loa (eye worm) ABC transporter 0.001 0.0005 0.0005
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0313 0.1302 0.2628
Toxoplasma gondii hypothetical protein 0.0023 0.0062 0.0369
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.002 0.012
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0047 0.0162 0.0205
Brugia malayi cytochrome P450 0.0043 0.0144 0.0223
Echinococcus granulosus SAM domain containing protein 0.0015 0.0026 0.0052
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0321 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0225 0.0347
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.013 0.013
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.04 0.1672 0.2118
Echinococcus multilocularis integrin alpha ps 0.0683 0.2881 0.5816
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0156 0.063 0.0797
Echinococcus granulosus fmrfamide receptor 0.002 0.0048 0.0096
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0244 0.1004 0.155
Plasmodium falciparum carbonic anhydrase 0.0134 0.0535 0.3201
Echinococcus multilocularis serotonin receptor 0.002 0.0048 0.0096
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0055 0.0069
Schistosoma mansoni nuclear hormone receptor 0.0039 0.013 0.0201
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0244 0.1004 0.1004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.002 0.0025
Onchocerca volvulus 0.0244 0.1004 0.8319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0048 0.0073
Brugia malayi RE15519p 0.002 0.0048 0.0073
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0084 0.0319 0.0644
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0112 0.0141
Brugia malayi hypothetical protein 0.0118 0.0466 0.072
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.012 0.0151
Brugia malayi Cation transporter family protein 0.0244 0.1004 0.155
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.002 0.0026
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.049 0.0758
Echinococcus multilocularis somatostatin receptor 0.002 0.0048 0.0096
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.049 0.0758
Loa Loa (eye worm) hypothetical protein 0.0126 0.0499 0.0499
Brugia malayi Death domain containing protein 0.0017 0.0036 0.0055
Echinococcus multilocularis tankyrase 0.0182 0.0739 0.1492
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0244 0.1004 0.2026
Echinococcus granulosus nAChR subunit 0.0244 0.1004 0.2026
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0033 0.0101 0.0203
Mycobacterium tuberculosis Conserved protein 0.0035 0.0112 0.0646
Schistosoma mansoni single-minded 0.0073 0.0276 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0084 0.0319 0.0644
Brugia malayi ecdysteroid receptor 0.0084 0.0319 0.0493
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.002 0.0046 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0084 0.0319 0.0319
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0062 0.0369
Onchocerca volvulus 0.0158 0.0637 0.5243
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0225 0.0454
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0043 0.0144 0.084
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.0314 0.0398
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit 0.0065 0.024 0.0484
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0043 0.0144 0.0791
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0017 0.0036 0.0045
Loa Loa (eye worm) hypothetical protein 0.014 0.0558 0.0558
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.015 0.0304
Echinococcus granulosus tankyrase 0.0182 0.0739 0.1492
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.012 0.0151
Schistosoma mansoni tankyrase 0.0182 0.0741 0.1144
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0048 0.0073
Schistosoma mansoni nAChR subunit 0.0118 0.0466 0.072
Echinococcus granulosus importin subunit beta 1 0.0029 0.0087 0.0176
Loa Loa (eye worm) hypothetical protein 0.0029 0.0087 0.0087
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0214 0.1278
Onchocerca volvulus 0.0024 0.0065 0.0445
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.047 0.0726
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0044 0.1933
Onchocerca volvulus 0.002 0.0048 0.0299
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0244 0.1004 0.2026
Echinococcus granulosus glycine receptor subunit alpha 1 0.0244 0.1004 0.2026
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.002 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0014 0.0018
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0214 0.0432
Echinococcus granulosus FTZ F1 alpha 0.0084 0.0319 0.0644
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0055 0.0069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0112
Brugia malayi multidrug resistance related protein 1 0.0017 0.0036 0.0055
Echinococcus granulosus Ankyrin 0.002 0.0047 0.0095
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0014 0.002 0.012
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0048 0.0096
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0832 0.3518 0.5435
Leishmania major cytochrome p450-like protein 0.0043 0.0144 0.0182
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0014 0.002 0.0119
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0062
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0156 0.0315
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0152 0.0612 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Brugia malayi Cation transporter family protein 0.0244 0.1004 0.155
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.1303 0.1303
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.002 0.0048 0.006
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0065 0.0082
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0225 1
Brugia malayi G-protein coupled receptor 0.002 0.0048 0.0073
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0277 0.035
Echinococcus granulosus muscleblind protein 0.0152 0.0612 0.1236
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0048 0.0096
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.013 0.0263
Loa Loa (eye worm) ACC-1 protein 0.0244 0.1004 0.1004
Echinococcus multilocularis tumor protein p63 0.0408 0.1706 0.3444
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0048 0.0048
Echinococcus multilocularis thyroid hormone receptor alpha 0.0236 0.0969 0.1956
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0048 0.0096
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0535 0.1081
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0017 0.0036 0.0045
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0244 0.1004 0.155
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0084 0.0319 0.0493
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0055 0.0069
Echinococcus multilocularis SAM domain containing protein 0.0015 0.0026 0.0052
Brugia malayi hypothetical protein 0.002 0.0048 0.0073
Echinococcus multilocularis chromobox protein 1 0.0084 0.0321 0.0649
Entamoeba histolytica ABC transporter, putative 0.0017 0.0036 0.0284
Echinococcus multilocularis sex peptide receptor 0.002 0.0048 0.0096
Plasmodium vivax tyrosine kinase-like protein, putative 0.0016 0.0031 0.0111
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0048 0.0048
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0012 0.0013 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0048 0.0096
Brugia malayi WGR domain containing protein 0.0198 0.0807 0.1246
Brugia malayi Nuclear hormone receptor E75 0.0039 0.013 0.0201
Echinococcus granulosus g protein coupled receptor 0.002 0.0048 0.0096
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit 0.0065 0.024 0.1431
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0009 0 0.0001
Brugia malayi GnHR receptor homolog 0.002 0.0048 0.0073
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0084 0.0319 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0014 0.0018
Loa Loa (eye worm) multidrug resistance-associated protein 0.0013 0.0019 0.0019
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.005 0.0176 0.0223
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1182 0.2387
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.013 0.0201
Loa Loa (eye worm) hypothetical protein 0.0044 0.015 0.015
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0048 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0084 0.0319 0.0493
Entamoeba histolytica hypothetical protein 0.0126 0.0499 0.6123
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0044 0.0055
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Schistosoma mansoni chromobox protein 0.0084 0.0321 0.0496
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0342 0.069
Entamoeba histolytica hypothetical protein 0.0027 0.0077 0.0804
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.04 0.1672 0.2583
Echinococcus granulosus chromobox protein 2 0.0014 0.002 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0036 0.0284
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0012 0.0014 0.0018
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0048 0.0048
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0048 0.0096
Schistosoma mansoni nAChR subunit 0.0244 0.1004 0.155
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0035 0.0183
Brugia malayi hypothetical protein 0.002 0.0048 0.0073
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0225 0.1342
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.002 0.0032
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0036 0.0072
Onchocerca volvulus 0.0084 0.0319 0.2576
Trypanosoma brucei poly(adp-ribose) polymerase 0.0119 0.0472 0.0598
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0039 0.014
Schistosoma mansoni netrin receptor unc5 0.0017 0.0036 0.0055
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0198 0.0807 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Echinococcus granulosus glycine receptor subunit alpha 1 0.0244 0.1004 0.2026
Toxoplasma gondii cytochrome p450 superfamily protein 0.0043 0.0144 0.0861
Schistosoma mansoni hypothetical protein 0.0327 0.1361 0.2102
Echinococcus multilocularis neuropeptide receptor A26 0.002 0.0048 0.0096
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.047 0.5756
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0039
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0048 0.0096
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Echinococcus granulosus glycine receptor subunit beta 0.0244 0.1004 0.2026
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative 0.002 0.0048 0.0283
Onchocerca volvulus 0.0291 0.1204 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi ABC transporter family protein 0.001 0.0005 0.0008
Leishmania major hypothetical protein, conserved 0.1856 0.7894 1
Entamoeba histolytica hypothetical protein 0.0043 0.0147 0.1692
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0112 0.0596
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Echinococcus multilocularis neuropeptide s receptor 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Onchocerca volvulus 0.0118 0.0466 0.3812
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Echinococcus multilocularis protein patched 0.0051 0.018 0.0363
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.04 0.1672 0.2118
Brugia malayi Neurabin protein 1 0.0015 0.0026 0.0039
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0112 0.0405
Onchocerca volvulus 0.0244 0.1004 0.8319
Schistosoma mansoni hypothetical protein 0.0049 0.0172 0.0265
Onchocerca volvulus 0.002 0.0048 0.0299
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0048 0.0073
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.1021 0.1578
Trypanosoma cruzi multidrug resistance protein E, putative 0.0017 0.0036 0.0045
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0535 0.0827
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1152 0.4887 0.755
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0065 0.0313
Schistosoma mansoni ABC transporter 0.001 0.0005 0.0008
Brugia malayi hypothetical protein 0.008 0.0302 0.0467
Brugia malayi protein-tyrosine kinase 0.0041 0.0137 0.0212
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.002 0.0026
Schistosoma mansoni biogenic amine receptor 0.002 0.0048 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0014 0.0018
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.04 0.1672 0.2118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0035 0.0183
Onchocerca volvulus Neuropeptide F receptor homolog 0.002 0.0048 0.0299
Trichomonas vaginalis adenylate cyclase, putative 0.0019 0.0043 0.0054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.015 0.0232
Onchocerca volvulus 0.002 0.0048 0.0299
Toxoplasma gondii ABC1 family protein 0.0035 0.0112 0.0667
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0244 0.1004 0.2026
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.012 0.0151
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0244 0.1004 0.155
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0214 0.0331
Schistosoma mansoni nAChR subunit 0.0244 0.1004 0.155
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0244 0.1004 0.2026
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0156 0.063 0.1271
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0126 0.0499 0.0771
Brugia malayi CHE-14 protein 0.0051 0.018 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.043 0.0545
Schistosoma mansoni amine GPCR 0.002 0.0048 0.0073
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0147 0.0297
Brugia malayi Protein cec-1. 0.0014 0.002 0.0032
Trypanosoma cruzi hypothetical protein 0.0013 0.0018 0.0022
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0012 0.0014 0.0016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.002 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0137 0.0277
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3524 0.7114
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Echinococcus granulosus multidrug resistance associated protein 1 0.0017 0.0036 0.0072
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0036 0.0284
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0065 0.0313
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0244 0.1004 0.2026
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.013 0.0263
Schistosoma mansoni carbonic anhydrase 0.0134 0.0535 0.0827
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0118 0.0466 0.072
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0048 0.0096
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0036 0.0056
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.0014 0.0029
Brugia malayi SET domain containing protein 0.0014 0.002 0.0032
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0043 0.0144 0.0182
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0073
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0005 0.0011
Plasmodium vivax importin-beta 2, putative 0.0029 0.0087 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0238 0.0301
Brugia malayi Valyl-tRNA synthetase 0.0014 0.002 0.0032
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0055 0.0529
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0179 0.0226
Trypanosoma cruzi hypothetical protein 0.1856 0.7894 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0036 0.0284
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0217 0.0335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0084 0.0319 0.0319
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0132 0.0266
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0036 0.0201
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0248 0.1021 0.1578
Trichomonas vaginalis Heterochromatin protein, putative 0.0014 0.002 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0065 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0084 0.0319 0.0493
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0019 0.0043 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.005 0.0176 0.0223
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0065 0.0313
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0048 0.0096
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0009 0 0.0001
Brugia malayi follicle stimulating hormone receptor 0.002 0.0048 0.0073
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0021 0.0032
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0112 0.0226
Brugia malayi beta-lactamase family protein 0.0035 0.0112 0.0173
Echinococcus multilocularis GPCR, family 2 0.0019 0.0043 0.0087
Brugia malayi nuclear receptor NHR-88 0.0039 0.013 0.0201
Brugia malayi Cation transporter family protein 0.0244 0.1004 0.155
Onchocerca volvulus 0.0126 0.0499 0.4086
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0009 0 0.0001
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.049 0.099
Entamoeba histolytica multidrug resistance protein, putative 0.0017 0.0036 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0032
Schistosoma mansoni chromobox protein 0.0014 0.002 0.0032
Onchocerca volvulus 0.0014 0.002 0.0072
Echinococcus multilocularis Ankyrin 0.002 0.0047 0.0096
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.04 0.1672 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0046 0.0158 0.032
Schistosoma mansoni amine GPCR 0.002 0.0048 0.0073
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0612 0.1234
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Leishmania major hypothetical protein, conserved 0.0023 0.0058 0.0074
Onchocerca volvulus 0.0014 0.002 0.0072
Schistosoma mansoni nAChR subunit 0.0244 0.1004 0.155
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0043 0.0144 0.084
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0048 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.012 0.0151
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0043 0.0144 0.0791
Toxoplasma gondii Alpha-galactosidase 0.0018 0.0036 0.0216
Echinococcus multilocularis expressed conserved protein 0.0112 0.0439 0.0886
Echinococcus granulosus tyrosine kinase 0.0041 0.0137 0.0277
Schistosoma mansoni hypothetical protein 0.0314 0.1303 0.2013
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0043 0.0144 0.0791
Onchocerca volvulus 0.002 0.0048 0.0299
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0156 0.0315
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.018 0.0363
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0043 0.0144 0.0182
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0225 0.0284
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi AKH receptor 0.002 0.0048 0.0073
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0065 0.0365
Echinococcus multilocularis FTZ F1 alpha 0.0084 0.0319 0.0644
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.1021 0.1293
Loa Loa (eye worm) GABA receptor subunit 0.0126 0.0499 0.0499
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0101 0.0127
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0087 0.011
Echinococcus multilocularis Chromobox protein 3 0.0014 0.002 0.0041
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0087 0.0176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0048 0.0073
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.04 0.1672 1
Schistosoma mansoni nAChR subunit 0.0118 0.0466 0.072
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0244 0.1004 0.1004
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.002 0.0026
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0043 0.0144 0.084
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0048 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0112 0.0141
Echinococcus granulosus allatostatin A receptor 0.002 0.0048 0.0096
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0009 0 0.0001
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0009 0 0.0001
Loa Loa (eye worm) LGC-31 protein 0.0244 0.1004 0.1004
Trypanosoma cruzi ABC transporter, putative 0.0012 0.0013 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Entamoeba histolytica hypothetical protein 0.0037 0.012 0.1345
Loa Loa (eye worm) hypothetical protein 0.0132 0.0526 0.0526
Schistosoma mansoni hypothetical protein 0.0019 0.0043 0.0066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0058
Schistosoma mansoni importin beta-1 0.0029 0.0087 0.0135
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0048 0.0073
Schistosoma mansoni neuropeptide receptor 0.002 0.0048 0.0073
Echinococcus granulosus serine protein kinase ATM 0.0012 0.0014 0.0029
Echinococcus multilocularis neuropeptide receptor 0.002 0.0048 0.0096
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0044 0.0088
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0084 0.0319 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Echinococcus granulosus g protein coupled receptor 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Schistosoma mansoni adenoreceptor 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0535 0.0827
Entamoeba histolytica hypothetical protein 0.0037 0.012 0.1345
Echinococcus multilocularis liprin alpha 2 0.0015 0.0026 0.0052
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0065 0.0313
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0535 0.0827
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0277 0.035
Echinococcus granulosus snurportin 1 0.0314 0.1303 0.263
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0044 0.0055
Onchocerca volvulus 0.006 0.0217 0.172
Echinococcus granulosus tumor protein p63 0.0408 0.1706 0.3444
Loa Loa (eye worm) hypothetical protein 0.0024 0.0065 0.0065
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0048 0.0096
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1182 0.2387
Echinococcus granulosus aryl hydrocarbon receptor 0.0159 0.064 0.1291
Echinococcus granulosus Protein patched homolog 1 0.0051 0.018 0.0363
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0112 0.0646
Brugia malayi conserved hypotetical protein 0.0039 0.013 0.0201
Schistosoma mansoni amine GPCR 0.002 0.0048 0.0073
Schistosoma mansoni hypothetical protein 0.0019 0.0043 0.0066
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0065 0.0654
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.047 0.0949
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Schistosoma mansoni cytochrome P450 0.0043 0.0144 0.0223
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0156 0.0315
Onchocerca volvulus 0.0039 0.013 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0014 0.0018
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0137 0.0277
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0048 0.0073
Brugia malayi Dopamine receptor protein 1 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0084 0.0319 0.0319
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0064 0.0235 0.0474
Echinococcus granulosus integrin alpha ps 0.0327 0.1361 0.2747
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0009 0 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0012 0.0014 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0084 0.0319 0.0493
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.013 0.0263
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0225 0.0284
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0065 0.0313
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0244 0.1004 0.155
Loa Loa (eye worm) steroid hormone receptor 0.0084 0.0319 0.0319
Schistosoma mansoni hypothetical protein 0.0205 0.0836 0.1292
Schistosoma mansoni neuropeptide receptor 0.002 0.0048 0.0073
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0225 0.0284
Loa Loa (eye worm) hypothetical protein 0.0024 0.0065 0.0065
Onchocerca volvulus 0.0035 0.0112 0.0839
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0225 0.0284
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0019 0.0043 0.0054
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0118 0.0466 0.072
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Echinococcus granulosus c src tyrosine kinase 0.001 0.0005 0.0011
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.013 0.0201
Brugia malayi Steroid receptor seven-up type 2 0.0084 0.0319 0.0493
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0277 0.035
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0013 0.0026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0048 0.0096
Brugia malayi Cytochrome P450 family protein 0.0043 0.0144 0.0223
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0277 0.035
Schistosoma mansoni opsin-like receptor 0.002 0.0048 0.0073
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.0134 0.0535 0.0535
Echinococcus granulosus serotonin receptor 0.002 0.0048 0.0096
Plasmodium vivax heterochromatin protein 1, putative 0.0014 0.002 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Brugia malayi bHLH-PAS transcription factor 0.0054 0.0194 0.03
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0039
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0048 0.0096
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0015 0.0026 0.0052
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0156 0.063 0.0797
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0013 0.0026
Brugia malayi Dopamine receptor protein 2 0.002 0.0048 0.0073
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0118 0.0466 0.0466
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0048 0.0096
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0013 0.0026
Echinococcus granulosus g protein coupled receptor 0.002 0.0048 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Echinococcus multilocularis geminin 0.0205 0.0836 0.1688
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0244 0.1004 0.155
Schistosoma mansoni biogenic amine receptor 0.002 0.0048 0.0073
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0126 0.0499 0.0771
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0084 0.0319 0.0493
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0101 0.0156
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0009 0 0.0001
Schistosoma mansoni hypothetical protein 0.0041 0.0138 0.0212
Schistosoma mansoni multidrug resistance protein 0.0017 0.0036 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0035 0.0183
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0063 0.008
Trichomonas vaginalis conserved hypothetical protein 0.1856 0.7894 1
Schistosoma mansoni nuclear hormone receptor 0.0084 0.0319 0.0493
Loa Loa (eye worm) hypothetical protein 0.0119 0.0472 0.0472
Loa Loa (eye worm) SRC-1 0.0045 0.0156 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0048 0.0096
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0048 0.0096
Brugia malayi hypothetical protein 0.0043 0.0147 0.0228
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0342 0.069
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.0062 0.0295
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0277 0.035
Trypanosoma brucei protein kinase, putative 0.0062 0.0225 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Mycobacterium leprae putative cytochrome p450 0.0043 0.0144 0.0621
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0048 0.0096
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.019 0.019
Echinococcus multilocularis glycine receptor subunit beta 0.0244 0.1004 0.2026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Loa Loa (eye worm) hypothetical protein 0.0047 0.0163 0.0163
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0688 0.1389
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.0055 0.0069
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0048 0.0096
Onchocerca volvulus 0.008 0.0302 0.2434
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.002 0.0048 0.006
Schistosoma mansoni neuropeptide receptor 0.002 0.0048 0.0073
Echinococcus granulosus poly adp ribose polymerase 2 0.0119 0.0472 0.0954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.002 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.012 0.0151
Onchocerca volvulus Tankyrase homolog 0.0165 0.0665 0.5479
Trichomonas vaginalis chromobox protein, putative 0.0014 0.002 0.0026
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0043 0.0144 0.0791
Brugia malayi Importin beta-1 subunit 0.0029 0.0087 0.0135
Loa Loa (eye worm) tnks protein 0.0167 0.0677 0.0677
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0005 0.0011
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0198 0.0807 0.1246
Echinococcus granulosus multidrug resistance associated protein 4 0.0013 0.0018 0.0036
Schistosoma mansoni nAChR subunit 0.0244 0.1004 0.155
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0118 0.0466 0.0466
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0158 0.0639 0.129
Brugia malayi hypothetical protein 0.0039 0.013 0.0201
Leishmania major p-glycoprotein e 0.0017 0.0036 0.0045
Leishmania major hypothetical protein, conserved 0.0035 0.0112 0.0141
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0043 0.0144 0.0791
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0048 0.0073
Echinococcus granulosus orexin receptor type 2 0.002 0.0048 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.018 0.0227
Echinococcus multilocularis protein dispatched 1 0.0058 0.0211 0.0425
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0012 0.0013 0.0016
Toxoplasma gondii FATC domain-containing protein 0.0012 0.0014 0.0083
Schistosoma mansoni nAChR subunit 0.0244 0.1004 0.155
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0214 0.0271
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0009 0 0.0001
Brugia malayi coiled-coil like protein 1 0.0015 0.0026 0.0039
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.0055 0.0069
Onchocerca volvulus 0.002 0.0048 0.0299
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0087 0.011
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0017 0.0036 0.0045
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0043 0.0087
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0087 0.052
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0244 0.1004 0.1004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0084 0.0319 0.0644
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0043 0.0144 0.0791
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni zinc finger protein 0.0039 0.013 0.0201
Entamoeba histolytica protein kinase, putative 0.0036 0.0118 0.1318
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0026
Schistosoma mansoni neurotransmitter gated ion channel 0.0126 0.0499 0.0771
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0244 0.1004 0.155
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0043 0.0144 0.0791
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.012 0.0151
Echinococcus granulosus neuropeptide s receptor 0.002 0.0048 0.0096
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0225 0.0454
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0048 0.0096
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0062 0.0115
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi Melibiase family protein 0.0082 0.0314 0.0485
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.002 0.0026
Onchocerca volvulus 0.0244 0.1004 0.8319
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0112 0.0141
Brugia malayi SRC-1 0.0045 0.0156 0.0241
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0277 0.035
Onchocerca volvulus Putative nachr subunit 0.0244 0.1004 0.8319
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.002 0.0046 0.0057
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0009 0 0.0001
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0019 0.0043 0.0054
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.018 0.018
Brugia malayi hypothetical protein 0.0015 0.0026 0.0039
Onchocerca volvulus 0.0126 0.0499 0.4086
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0048 0.0073
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0017 0.0036 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Loa Loa (eye worm) hypothetical protein 0.0126 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0062 0.0295
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0065 0.0313
Schistosoma mansoni acetylcholine receptor-related 0.0118 0.0466 0.072
Brugia malayi Ectopic membrane ruffles in embryo protein 1 0.0065 0.024 0.037
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0156 0.063 0.1271
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0112 0.0646
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0044 0.0055
Onchocerca volvulus 0.002 0.0048 0.0299
Toxoplasma gondii melibiase subfamily protein 0.0124 0.049 0.2931
Toxoplasma gondii hypothetical protein 0.0023 0.0062 0.0369
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0048 0.0073
Onchocerca volvulus 0.002 0.0048 0.0299
Echinococcus granulosus neuropeptide receptor 0.002 0.0048 0.0096
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0048 0.0073
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0009 0 0.0001
Echinococcus multilocularis integrin alpha ps 0.0683 0.2881 0.5816
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0043 0.0144 0.0791
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0065 0.0654
Echinococcus multilocularis jun protein 0.0101 0.0395 0.0798
Onchocerca volvulus 0.0037 0.012 0.0904
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 0.0065 0.024 0.024
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0065 0.0654
Brugia malayi hypothetical protein 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0286 0.1182 0.1182
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.002 0.0032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0147 0.0297
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0043 0.0144 0.084
Brugia malayi beta-lactamase family protein 0.0035 0.0112 0.0173
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0126 0.0499 0.0771
Loa Loa (eye worm) beta-lactamase 0.0035 0.0112 0.0112
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0043 0.0144 0.0791
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0043 0.0144 0.084
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0055 0.0111
Echinococcus granulosus single minded 2 0.0054 0.0194 0.0392
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0214 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Echinococcus multilocularis chromobox protein 1 0.0084 0.0321 0.0649
Onchocerca volvulus 0.0244 0.1004 0.8319
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0048 0.0096
Onchocerca volvulus 0.0244 0.1004 0.8319
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0244 0.1004 0.155
Echinococcus granulosus ecdysone induced protein 78C 0.0084 0.0319 0.0644
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Echinococcus granulosus chromobox protein 1 0.0084 0.0321 0.0649
Onchocerca volvulus 0.0015 0.0026 0.0114
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.018 0.0363
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0156 0.0315
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0055 0.0069
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0082 0.0314 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0014 0.0018
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0048 0.0096
Brugia malayi neuropeptide F receptor 0.002 0.0048 0.0073
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0179 0.0226
Leishmania major ubiquitin activating enzyme, putative 0.002 0.0048 0.006
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0065 0.01
Schistosoma mansoni myosin xvIII 0.002 0.0048 0.0073
Onchocerca volvulus 0.0058 0.0211 0.1667
Schistosoma mansoni amine GPCR 0.002 0.0048 0.0073
Onchocerca volvulus 0.0015 0.0026 0.0114
Schistosoma mansoni hypothetical protein 0.0017 0.0036 0.0055
Loa Loa (eye worm) carbonic anhydrase 3 0.0248 0.1021 0.1021
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0126 0.0499 0.0771
Loa Loa (eye worm) hypothetical protein 0.0024 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0048 0.0073
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0043 0.0144 0.0791
Toxoplasma gondii hypothetical protein 0.0134 0.0535 0.3201
Onchocerca volvulus 0.0055 0.0197 0.155
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0244 0.1004 0.2026
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0062 0.0369
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0015 0.0026 0.0039
Schistosoma mansoni nuclear receptor 0.0039 0.013 0.0201
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0048 0.0096
Schistosoma mansoni opsin-like receptor 0.002 0.0048 0.0073
Echinococcus multilocularis carbonic anhydrase II 0.0248 0.1021 0.2062
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0156 0.0315
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0048 0.0073
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.013 0.0263
Onchocerca volvulus 0.002 0.0048 0.0299
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0043 0.0144 0.084
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0043 0.0144 0.0791
Echinococcus multilocularis nAChR subunit 0.0126 0.0499 0.1007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Echinococcus multilocularis multidrug resistance associated protein 7 0.0017 0.0036 0.0072
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0009 0 0.0001
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0119 0.0472 0.0598
Brugia malayi WGR domain containing protein 0.0119 0.0472 0.073
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0053 0.019 0.1064
Brugia malayi PAS domain containing protein 0.0073 0.0276 0.0426
Brugia malayi tailless protein 0.0039 0.013 0.0201
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0134 0.0535 0.0535
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0065 0.0133
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0043 0.0144 0.0791
Echinococcus granulosus carbonic anhydrase 0.0134 0.0535 0.1081
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0248 0.1021 0.1021
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0225 0.0284
Brugia malayi Protein kinase domain containing protein 0.0018 0.0038 0.0059
Loa Loa (eye worm) hypothetical protein 0.0084 0.0319 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0084 0.0319 0.0493
Schistosoma mansoni tyrosine kinase 0.001 0.0005 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Echinococcus multilocularis Chromo domain 0.0014 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0017 0.0036 0.0045
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0313 0.1302 0.2628
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0225 0.0454
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.002 0.0046 0.0046
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0048 0.0073
Onchocerca volvulus 0.002 0.0048 0.0299
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0112 0.0173
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0244 0.1004 0.155
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0043 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0112
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0055 0.0085
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0118 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0039
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0084 0.0319 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0163 0.0206
Echinococcus multilocularis g protein coupled receptor 0.002 0.0048 0.0096
Echinococcus granulosus glycine receptor subunit alpha 1 0.0244 0.1004 0.2026
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0048 0.0096
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0118 0.0466 0.0941
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.1021 0.1578
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0156 0.063 0.7768
Loa Loa (eye worm) hypothetical protein 0.0158 0.0637 0.0637
Schistosoma mansoni hypothetical protein 0.0058 0.0211 0.0325
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0225 0.0454
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0653 0.2752 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0244 0.1004 0.2026
Entamoeba histolytica hypothetical protein 0.0037 0.012 0.1345
Brugia malayi hypothetical protein 0.0286 0.1182 0.1826
Schistosoma mansoni histamine h1 receptor 0.002 0.0048 0.0073
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0034 0.1517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0014 0.0018
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0074 0.0277 0.0558
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0055 0.0327
Loa Loa (eye worm) hypothetical protein 0.0126 0.0499 0.0499
Plasmodium vivax ubiquitin-activating enzyme E1C, putative 0.002 0.0048 0.0172
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0043 0.0144 0.084
Echinococcus granulosus carbonic anhydrase 0.0134 0.0535 0.1081
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0074 0.0277 0.035
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0101 0.0127
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0043 0.0144 0.084
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0244 0.1004 0.155
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0043 0.0144 0.084
Schistosoma mansoni hypothetical protein 0.0014 0.002 0.0032
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.002 0.0094
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0019 0.0043 0.0054
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Schistosoma mansoni tyrosine kinase 0.0045 0.0156 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0104 0.0132
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.002 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0048 0.0096
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3524 0.7114
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0043 0.0144 0.084
Schistosoma mansoni nAChR subunit 0.0244 0.1004 0.155
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0156 0.0315
Trypanosoma brucei p-glycoprotein 0.0017 0.0036 0.0045
Echinococcus granulosus expressed conserved protein 0.0112 0.0439 0.0886
Brugia malayi nuclear receptor RXR 0.0039 0.013 0.0201
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi hypothetical protein 0.002 0.0048 0.0073
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0009 0 0.0001
Onchocerca volvulus Bile acid receptor homolog 0.0084 0.0319 0.2576
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0244 0.1004 0.2026
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0063 0.008
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.002 0.012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0356 0.1482 0.1482
Leishmania major carbonic anhydrase-like protein 0.0248 0.1021 0.1293
Schistosoma mansoni hypothetical protein 0.0019 0.0043 0.0066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0219 0.0338
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0019 0.0043 0.0066
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.013 0.0992
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.0014 0.0022
Echinococcus granulosus Chromobox protein 3 0.0014 0.002 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.0319 0.0644
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0126 0.0499 0.0499
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0084 0.0319 0.0493
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0156 0.0315
Mycobacterium ulcerans lipase LipD 0.0035 0.0112 0.0596
Echinococcus granulosus poly (ADP ribose) polymerase 0.0054 0.0192 0.0388
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0225 0.0284
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.0319 0.0644
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0048 0.0073
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.015 0.0232
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0118 0.0466 0.0941
Echinococcus granulosus neuropeptide receptor 0.002 0.0048 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.002 0.0026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0036 0.0055
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.015 0.015
Loa Loa (eye worm) TK protein kinase 0.0036 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0139 0.0555 0.0555
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0043 0.0144 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0238 0.0301
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0084 0.0319 0.0644
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.013 0.0201
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0036 0.157
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0012 0.0013 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0048 0.0096
Loa Loa (eye worm) cytochrome P450 family protein 0.0112 0.044 0.044
Giardia lamblia ABC transporter 0.0012 0.0012 0.0513
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.1204 0.1204
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0126 0.0499 0.0771
Brugia malayi ORL1-like opioid receptor 0.002 0.0048 0.0073
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.002 0.0046 0.0057
Onchocerca volvulus 0.002 0.0048 0.0299
Echinococcus granulosus integrin alpha ps 0.0683 0.2881 0.5816
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.013 0.0263
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0219 0.0219
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0132 0.0266
Echinococcus multilocularis fmrfamide receptor 0.002 0.0048 0.0096
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.002 0.0025
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0048 0.0096
Schistosoma mansoni hypothetical protein 0.0049 0.0172 0.0265
Echinococcus granulosus liprin beta 1 0.0015 0.0026 0.0052
Loa Loa (eye worm) CYP4Cod1 0.0053 0.019 0.019
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0048 0.0096
Onchocerca volvulus 0.002 0.0048 0.0299
Trichomonas vaginalis guanylate cyclase, putative 0.0019 0.0043 0.0054
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.002 0.0046 0.0057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0043 0.0087
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0244 0.1004 0.2026
Leishmania major cytochrome p450-like protein 0.0053 0.019 0.024
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0244 0.1004 0.1004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0112 0.0646
Leishmania major ABC-thiol transporter 0.0017 0.0036 0.0045
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0112 0.0646
Entamoeba histolytica hypothetical protein 0.0014 0.002 0.0094
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0077 0.0155
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0019 0.0043 0.0054
Echinococcus granulosus Chromo domain 0.0014 0.002 0.0041
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0244 0.1004 0.155
Trypanosoma brucei carbonic anhydrase-like protein 0.0248 0.1021 0.1293
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0225 0.0284
Loa Loa (eye worm) follicle stimulating hormone receptor 0.002 0.0048 0.0048
Brugia malayi nuclear receptor RXR 0.0044 0.015 0.0232
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0214 0.1212
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0244 0.1004 0.155
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0244 0.1004 0.2026
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3524 0.5444
Brugia malayi hypothetical protein 0.0118 0.0466 0.072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0023 0.0062 0.0347
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0163 0.1269
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0118 0.0237
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Schistosoma mansoni hypothetical protein 0.0043 0.0147 0.0228
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0156 0.063 0.0797
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0055 0.0069
Echinococcus multilocularis g protein coupled receptor 0.002 0.0048 0.0096
Entamoeba histolytica hypothetical protein 0.0012 0.0014 0.0016
Brugia malayi Dopamine receptor 0.002 0.0048 0.0073
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.0277 0.035
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0048 0.0073
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0156 0.0315
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0048 0.0073
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0041 0.0138 0.0138
Brugia malayi photoreceptor-specific nuclear receptor 0.0084 0.0319 0.0493
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0048 0.0096
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0036
Schistosoma mansoni RAR-like nuclear receptor 0.0084 0.0319 0.0493
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0156 0.0315
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0048 0.0096
Schistosoma mansoni chromobox protein 0.0014 0.002 0.0032
Leishmania major DNA repair protein, putative 0.0023 0.0058 0.0074
Echinococcus granulosus integrin alpha 3 0.1168 0.4954 1
Schistosoma mansoni integrin alpha-ps 0.0683 0.2881 0.445
Echinococcus granulosus Sterile alpha motif SAM 0.0015 0.0026 0.0052
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.002 0.0046 0.0093
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0048 0.0073
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0244 0.1004 0.2026
Schistosoma mansoni lip-related protein (liprin) alpha 0.0015 0.0026 0.0039
Echinococcus granulosus nAChR subunit 0.0126 0.0499 0.1007
Brugia malayi Nuclear hormone receptor-like 1 0.0084 0.0319 0.0493
Loa Loa (eye worm) ACC-1 protein 0.0244 0.1004 0.1004
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0277 0.035
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.04 0.1672 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0055 0.0085
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0084 0.0319 0.0644
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0048 0.0096
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0039 0.023
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0009 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0026
Onchocerca volvulus 0.0244 0.1004 0.8319
Loa Loa (eye worm) hypothetical protein 0.084 0.3554 0.3554
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0112 0.0422
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0048 0.0096
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.002 0.0032
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.013 0.0992
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0062 0.0078
Echinococcus multilocularis nAChR subunit 0.0244 0.1004 0.2026
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0225 0.0225
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.002 0.0041
Echinococcus multilocularis integrin alpha 3 0.1168 0.4954 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0009 0 0.0001
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.013 0.0201
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0073
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0156 0.063 0.0797
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0156 0.0315
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0198 0.0807 0.1629
Echinococcus granulosus liprin alpha 2 0.0015 0.0026 0.0052
Echinococcus granulosus hypothetical protein 0.002 0.0048 0.0096
Echinococcus multilocularis ecdysone induced protein 78C 0.0084 0.0319 0.0644
Echinococcus granulosus sex peptide receptor 0.002 0.0048 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0048 0.0073
Trichomonas vaginalis chromobox protein, putative 0.0014 0.002 0.0026
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0009 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0118 0.0466 0.072
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.013 0.0201
Echinococcus multilocularis multidrug resistance associated protein 4 0.0013 0.0018 0.0036
Loa Loa (eye worm) hypothetical protein 0.0152 0.0612 0.0612
Schistosoma mansoni hypothetical protein 0.0049 0.0172 0.0265
Plasmodium falciparum importin beta, putative 0.0029 0.0087 0.052
Schistosoma mansoni steroid hormone receptor ad4bp 0.0084 0.0319 0.0493
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0043 0.0144 0.084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0009 0 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0043 0.0144 0.084
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0009 0 0.0001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0044 0.0068
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0048 0.0096
Brugia malayi hypothetical protein 0.0039 0.013 0.0201
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0044 0.0185
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0244 0.1004 0.2026
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.002 0.0048 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0112 0.0141
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.0036 0.0211
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0101 0.0127
Echinococcus granulosus neuropeptide receptor A26 0.002 0.0048 0.0096
Schistosoma mansoni thyroid hormone receptor 0.0236 0.0969 0.1497
Entamoeba histolytica hypothetical protein 0.0024 0.0063 0.0636
Onchocerca volvulus 0.002 0.0048 0.0299
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0535 0.1081
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.0051 0.018 0.018
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.002 0.0041
Onchocerca volvulus 0.002 0.0048 0.0299
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.0319 0.0644
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.012 0.0151
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0225 0.0284
Loa Loa (eye worm) acetylcholine receptor protein 0.0118 0.0466 0.0466
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0084 0.0319 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0043 0.0054
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0037 0.0058
Trypanosoma brucei ATP-binding cassette protein, putative 0.0012 0.0013 0.0016
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0138 0.0212
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Echinococcus granulosus carbonic anhydrase II 0.0248 0.1021 0.2062
Echinococcus multilocularis neuropeptide receptor 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Brugia malayi ecdysone receptor 0.0039 0.013 0.0201
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0074 0.0277 0.0427
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0009 0 0.0001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0118 0.0466 0.072
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0032
Brugia malayi G-protein coupled receptor 0.002 0.0048 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0112 0.0141
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.002 0.0048 0.0299
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0043 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0043 0.0066
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0055 0.0111
Brugia malayi Cytochrome P450 family protein 0.0053 0.019 0.0293
Brugia malayi Nuclear hormone receptor E75 0.0039 0.013 0.0201
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0137 0.0277
Brugia malayi G protein-coupled receptor 0.002 0.0048 0.0073
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0036 0.0072
Mycobacterium ulcerans putative regulatory protein 0.0054 0.0194 0.109
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0033 0.0101 0.0156
Schistosoma mansoni survival motor neuron protein 0.0058 0.0211 0.0325
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0044 0.0237
Brugia malayi ABC transporter transmembrane region family protein 0.0017 0.0036 0.0055
Loa Loa (eye worm) hypothetical protein 0.1196 0.5074 0.5074
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0204 0.0836 0.4997
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0219 0.0338
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.002 0.0032
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0612 0.1234
Schistosoma mansoni multidrug resistance protein 0.0017 0.0036 0.0055
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.002 0.0032
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0277 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.0277 0.035
Brugia malayi chromobox protein homolog 3 0.0047 0.0163 0.0252
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.04 0.1672 0.6075
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0112 0.0141
Giardia lamblia ABC transporter, putative 0.0017 0.0036 0.157
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0044 0.5
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0043 0.0144 0.084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0084 0.0319 0.0493
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.013 0.0201
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0033 0.0101 0.0203
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0084 0.0319 0.0493
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0013 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0225 0.0284
Plasmodium falciparum ABC transporter G family member 2 0.0012 0.0013 0.0076
Trypanosoma cruzi cytochrome P450, putative 0.0053 0.019 0.024
Brugia malayi hypothetical protein 0.002 0.0048 0.0073
Echinococcus granulosus GPCR family 2 0.0019 0.0043 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0065 0.01
Brugia malayi putative neuropeptide receptor 0.002 0.0048 0.0073
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0244 0.1004 0.2026
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0214 0.1258
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.002 0.0026
Trypanosoma brucei multidrug resistance protein E 0.0017 0.0036 0.0045
Schistosoma mansoni nuclear receptor 0.0039 0.013 0.0201
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0244 0.1004 0.2026
Schistosoma mansoni hypothetical protein 0.0082 0.0314 0.0485
Onchocerca volvulus 0.0035 0.0112 0.0839
Trypanosoma brucei nucleoside 2-deoxyribosyltransferase 0.1856 0.7894 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0219 0.0219
Echinococcus granulosus somatostatin receptor 0.002 0.0048 0.0096
Brugia malayi Tnks protein 0.0181 0.0733 0.1133
Loa Loa (eye worm) hypothetical protein 0.0044 0.015 0.015
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0119 0.0472 0.0954
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0048 0.0096
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0244 0.1004 0.2026
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.001 0.0002 0.0005
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0101 0.0395 0.0798
Schistosoma mansoni patched 1 0.0051 0.018 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.002 0.0026
Echinococcus multilocularis serine protein kinase ATM 0.0012 0.0014 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0043 0.0144 0.084
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0048 0.0073
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0048 0.0048
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0112
Brugia malayi RNA, U transporter 1 0.0084 0.0319 0.0493
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0055 0.0111
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0009 0 0.0001
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0118 0.0466 0.0941
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0015 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0101
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0005 0.0008
Loa Loa (eye worm) cytochrome P450 0.0043 0.0144 0.0144
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0214 0.0432
Echinococcus multilocularis multidrug resistance associated protein 1 0.0017 0.0036 0.0072
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.002 0.0026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0044 0.0088
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0225 0.0284
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0015 0.0026 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.0053 0.019 0.024
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0156 0.0315
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0009 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0126 0.0499 0.0771
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0137 0.0277
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0043 0.0144 0.084
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0019 0.0043 0.0054
Brugia malayi nuclear receptor NHR-67 0.0039 0.013 0.0201
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0048 0.0096
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0244 0.1004 0.2026
Schistosoma mansoni integrin alpha 0.1523 0.6474 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0499 0.0499
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0065 0.01
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.002 0.0041
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0043 0.0144 0.0791
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0043 0.0144 0.0791
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0244 0.1004 0.155
Loa Loa (eye worm) hypothetical protein 0.0082 0.0314 0.0314
Leishmania major protein kinase, putative 0.002 0.0046 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0043 0.0144 0.084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.0319 0.0644
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0023 0.0062 0.0347
Brugia malayi MAP kinase sur-1 0.0062 0.0225 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.012 0.0151
Entamoeba histolytica protein kinase rad3, putative 0.0012 0.0014 0.0016
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0321 0.0321
Echinococcus granulosus g-protein coupled receptor 0.002 0.0048 0.0096
Echinococcus granulosus glycine receptor subunit beta 0.0244 0.1004 0.2026
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.049 0.0758
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0043 0.0066
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0018 0.0036 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni tyrosine kinase 0.0045 0.0156 0.0241
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.1021 0.1293
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.0014 0.0029
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.047 0.0949
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0244 0.1004 0.155
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0156 0.0315
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0225 0.0284
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0043 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0014 0.0018
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0688 0.1389
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.013 0.0263
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0244 0.1004 0.155
Loa Loa (eye worm) hypothetical protein 0.0327 0.1361 0.1361
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0026
Echinococcus multilocularis g protein coupled receptor 0.002 0.0048 0.0096
Echinococcus multilocularis serotonin receptor 0.002 0.0048 0.0096
Schistosoma mansoni hypothetical protein 0.0152 0.0612 0.0945
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.015 0.0232
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0048 0.0048
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0048 0.0096
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0048 0.0073
Trypanosoma brucei cytochrome P450, putative 0.0053 0.019 0.024
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0074 0.0277 0.0558
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0014 0.002 0.012
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0009 0 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0044 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0012 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0055 0.0111
Mycobacterium tuberculosis Conserved protein 0.0035 0.0112 0.0646
Loa Loa (eye worm) hypothetical protein 0.0714 0.3014 0.3014
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0478 0.0738
Trypanosoma cruzi DNA repair protein, putative 0.0023 0.0058 0.0074
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0043 0.0144 0.0182
Brugia malayi nuclear hormone receptor 0.0084 0.0319 0.0493
Echinococcus granulosus cytochrome P450 2K1 0.0043 0.0144 0.0291
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0012 0.0013 0.002
Echinococcus granulosus stromal interaction molecule 1 0.0015 0.0026 0.0052
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0147 0.0228
Leishmania major hypothetical protein, conserved 0.0114 0.0448 0.0567
Loa Loa (eye worm) hypothetical protein 0.0832 0.3518 0.3518
Brugia malayi Pax transcription factor protein 2 0.0291 0.1204 0.186
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.001 0.0002 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0084 0.0319 0.0493
Mycobacterium leprae Conserved hypothetical protein 0.0043 0.0144 0.0621
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0137 0.0277
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0156 0.063 0.1271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0084 0.0319 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0032
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0985 0.417 0.417
Trypanosoma cruzi hypothetical protein 0.1856 0.7894 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0112 0.0596
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0244 0.1004 0.155
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0043 0.0144 0.0791
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0084 0.0319 0.0644
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0112 0.0173
Entamoeba histolytica hypothetical protein 0.0014 0.002 0.0094
Loa Loa (eye worm) hypothetical protein 0.0126 0.0499 0.0499
Echinococcus granulosus multidrug resistance associated protein 7 0.0017 0.0036 0.0072
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Trypanosoma brucei ABC transporter, putative 0.0012 0.0013 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0032
Brugia malayi Heterochromatin protein 1 0.0084 0.0321 0.0496
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0036 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.1856 0.7894 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.002 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0043 0.0144 0.084
Plasmodium vivax hypothetical protein, conserved 0.0014 0.002 0.0073
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0084 0.0319 0.0319
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.019 0.019
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0019 0.0043 0.0054
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0055 0.0069
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0048 0.0073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0014 0.0022
Schistosoma mansoni neuropeptide receptor 0.002 0.0048 0.0073
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.0277 0.035
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0179 0.1398
Brugia malayi sulfakinin receptor protein 0.002 0.0048 0.0073
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0006
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0043 0.0144 0.0791
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0093 0.0357 0.0357
Schistosoma mansoni hypothetical protein 0.0134 0.0535 0.0827
Entamoeba histolytica hypothetical protein 0.0017 0.0036 0.0284
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0048 0.0048
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.0535 0.0827
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0048 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.012 0.0151
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0277 0.035
Loa Loa (eye worm) hypothetical protein 0.0084 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Brugia malayi nuclear hormone receptor 0.0039 0.013 0.0201
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0244 0.1004 0.155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0112
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.013 0.0263
Brugia malayi Serotonin receptor 0.002 0.0048 0.0073
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0139 0.0555 0.0858
Schistosoma mansoni opsin-like receptor 0.002 0.0048 0.0073
Trichomonas vaginalis hypothetical protein 0.0014 0.002 0.0026
Echinococcus granulosus poly ADP ribose polymerase 1 0.0198 0.0807 0.1629
Toxoplasma gondii hypothetical protein 0.0065 0.0238 0.1421
Mycobacterium ulcerans hypothetical protein 0.0035 0.0112 0.0596
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0048 0.0096
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0044 0.015 0.015
Onchocerca volvulus 0.002 0.0048 0.0299
Entamoeba histolytica hypothetical protein 0.0043 0.0147 0.1692
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0017 0.0036 0.0036
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0156 0.063 0.0797
Schistosoma mansoni chromobox protein 0.0084 0.0321 0.0496
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0043 0.0144 0.0791
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.013 0.0263
Brugia malayi nuclear receptor NHR-88 0.0084 0.0319 0.0493
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0244 0.1004 0.1004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0214 0.1212
Schistosoma mansoni sarm1 0.0015 0.0026 0.0039
Plasmodium vivax hypothetical protein, conserved 0.0014 0.002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0039
Schistosoma mansoni acetylcholine receptor subunit beta 0.0118 0.0466 0.072
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0612 0.1236
Loa Loa (eye worm) hypothetical protein 0.0126 0.0499 0.0499
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.04 0.1672 1
Trypanosoma cruzi hypothetical protein, conserved 0.1856 0.7894 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0055 0.0069
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.015 0.0232
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Echinococcus multilocularis allatostatin A receptor 0.002 0.0048 0.0096
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0055 0.0069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0014 0.0022
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0036 0.0072
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0023 0.0058 0.0074
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0244 0.1004 0.155
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0048 0.0096
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0077 0.0155
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0156 0.063 0.1271
Schistosoma mansoni tyrosine kinase 0.001 0.0005 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0065 0.0082
Schistosoma mansoni hypothetical protein 0.0205 0.0836 0.1292
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0035 0.0183
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0063 0.008
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0055 0.0069
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0244 0.1004 0.155
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0084 0.0319 0.0319
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0014 0.002 0.012
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0244 0.1004 0.2026
Mycobacterium leprae Probable lipase LipE 0.0035 0.0112 0.0422
Giardia lamblia GTOR 0.0022 0.0055 0.2436
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.013 0.0263
Brugia malayi excitatory GABA receptor EXP-1A 0.0244 0.1004 0.155
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0048 0.0096
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0055 0.0085
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0039
Trichomonas vaginalis esterase, putative 0.0035 0.0112 0.0141
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.013 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0048 0.0096
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0084 0.0319 0.0493
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0043 0.0144 0.084
Plasmodium falciparum tyrosine kinase-like protein 0.0016 0.0031 0.0183
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0043
Schistosoma mansoni jun-related protein 0.0082 0.0314 0.0485
Loa Loa (eye worm) hypothetical protein 0.0134 0.0535 0.0535
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0084 0.0319 0.0644
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0065 0.024 0.037
Loa Loa (eye worm) hypothetical protein 0.006 0.0217 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0048 0.0073
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0048 0.0096
Schistosoma mansoni retinoic acid receptor RXR 0.0203 0.0828 0.1279
Onchocerca volvulus DNA ligase 3 homolog 0.0023 0.0058 0.0391
Loa Loa (eye worm) TK protein kinase 0.0041 0.0137 0.0137
Brugia malayi hypothetical protein 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.1856 0.7894 1
Entamoeba histolytica zinc finger protein, putative 0.0037 0.012 0.1345
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0048 0.0073
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0112 0.0141
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.049 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Leishmania major importin beta-1 subunit, putative 0.0024 0.0063 0.008
Brugia malayi Serotonin receptor 0.002 0.0048 0.0073
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0016 0.0028 0.0165
Schistosoma mansoni neurotransmitter gated ion channel 0.0118 0.0466 0.072
Echinococcus multilocularis orexin receptor type 2 0.002 0.0048 0.0096
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0048 0.0073
Echinococcus granulosus chromobox protein 1 0.0084 0.0321 0.0649
Echinococcus granulosus geminin 0.0205 0.0836 0.1688
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0019 0.0043 0.0054
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0023 0.0058 0.0074
Schistosoma mansoni biogenic amine receptor 0.002 0.0048 0.0073
Leishmania major dihydroorotate dehydrogenase 0.04 0.1672 0.2118
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0048 0.0096
Brugia malayi hypothetical protein 0.0118 0.0466 0.072
Echinococcus multilocularis aryl hydrocarbon receptor 0.0159 0.064 0.1291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0036
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0017 0.0036 0.0045
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0118 0.0466 0.0941
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.002 0.0026
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0277 0.035
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0048 0.0096
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0039 0.0208
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0048 0.0096
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.0176 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0084 0.0319 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0119 0.0472 0.0598
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0156 0.0315
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0044 0.0386
Schistosoma mansoni integrin alpha-ps 0.0356 0.1482 0.2289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0048 0.0073
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0156 0.0315
Brugia malayi hypothetical protein 0.002 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0043
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0048 0.0073
Toxoplasma gondii exonuclease III APE 0.0019 0.0044 0.0259
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0043 0.0144 0.084
Brugia malayi Muscleblind-like protein 0.0152 0.0612 0.0946
Trypanosoma brucei NEDD8 activating enzyme subunit, putative 0.002 0.0048 0.006
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0009 0 0.0001
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.04 0.1672 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0044 0.0158
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0044 0.0055
Echinococcus granulosus WGR domain containing protein 0.0054 0.0192 0.0388
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0244 0.1004 0.155
Loa Loa (eye worm) hypothetical protein 0.1152 0.4887 0.4887
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0065 0.0082
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0055 0.0069
Schistosoma mansoni hypothetical protein 0.0049 0.0172 0.0265
Echinococcus multilocularis snurportin 1 0.0314 0.1303 0.263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Schistosoma mansoni thyroid hormone receptor 0.0236 0.0969 0.1497
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0033 0.0101 0.0156
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0055 0.0529
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0065 0.024 0.2854
Brugia malayi bZIP transcription factor family protein 0.0101 0.0395 0.061
Plasmodium vivax ABC transporter G family member 2, putative 0.0012 0.0013 0.0046
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.015 0.0304
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0048 0.0096
Echinococcus multilocularis glycine receptor subunit beta 0.0244 0.1004 0.2026
Onchocerca volvulus 0.002 0.0048 0.0299
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0065 0.0133
Brugia malayi hypothetical protein 0.002 0.0048 0.0073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0112 0.0173
Onchocerca volvulus Protein ultraspiracle homolog 0.0084 0.0319 0.2576
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0084 0.0319 0.0493
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0048 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0014 0.0018
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0119 0.0472 0.073
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0055 0.0055
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0118 0.0466 0.072
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi hypothetical protein 0.0044 0.015 0.0232
Schistosoma mansoni ap endonuclease 0.0019 0.0044 0.0068
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0112 0.0646
Brugia malayi neuropeptide F receptor 0.002 0.0048 0.0073
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Leishmania major pentamidine resistance protein 1 0.0017 0.0036 0.0045
Entamoeba histolytica hypothetical protein 0.0043 0.0147 0.1692
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0277 0.035
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0084 0.0319 0.0319
Echinococcus granulosus carbonic anhydrase 0.0134 0.0535 0.1081
Brugia malayi hypothetical protein 0.0014 0.0022 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0214 0.1212
Echinococcus multilocularis transfer RNA-Lys 0.0054 0.0194 0.0392
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0043 0.0144 0.0791
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0112 0.0112
Brugia malayi hypothetical protein 0.0118 0.0466 0.072
Schistosoma mansoni hypothetical protein 0.0043 0.0144 0.0223
Brugia malayi Zinc finger, C2H2 type family protein 0.0156 0.063 0.0973
Brugia malayi Integrin alpha pat-2 precursor 0.1523 0.6474 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.002 0.0026
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0084 0.0319 0.2576
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0535 0.0827
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Schistosoma mansoni aryl hydrocarbon receptor 0.0213 0.0872 0.1347
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0156 0.063 0.0797
Brugia malayi Liprin-alpha 2 0.0015 0.0026 0.0039
Echinococcus multilocularis integrin alpha ps 0.0327 0.1361 0.2747
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0314 0.0485
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.002 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0039
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.0055 0.0069
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.04 0.1672 0.2583
Mycobacterium tuberculosis Conserved protein 0.0035 0.0112 0.0646
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.04 0.1672 0.2118
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0026
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0012 0.0014 0.0018
Echinococcus multilocularis muscleblind protein 0.0152 0.0612 0.1236
Echinococcus multilocularis fmrfamide receptor 0.002 0.0048 0.0096
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.002 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0048 0.0048
Echinococcus multilocularis liprin beta 1 0.0015 0.0026 0.0052
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0321 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0065 0.0313
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0084 0.0319 0.0644
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0112 0.0646
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0048 0.0096
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0048 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0084 0.0319 0.0493
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.002 0.0026
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0048 0.0096
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0535 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.002 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.0244 0.1004 0.1004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0043 0.0054
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0036 0.0284
Loa Loa (eye worm) hypothetical protein 0.0126 0.0499 0.0499
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0112 0.0596
Brugia malayi FAT domain containing protein 0.001 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.0055 0.0069
Schistosoma mansoni dihydroorotate dehydrogenase 0.04 0.1672 0.2583
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0922 0.5501
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0101 0.0395 0.0798
Schistosoma mansoni nAChR subunit 0.0244 0.1004 0.155
Entamoeba histolytica hypothetical protein 0.0014 0.002 0.0094
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0019 0.0043 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0238 0.0301
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0055 0.0069
Brugia malayi Melatonin receptor type 1A 0.002 0.0048 0.0073
Plasmodium falciparum protein kinase, putative 0.0016 0.0031 0.0183
Trichomonas vaginalis chromobox protein, putative 0.0014 0.002 0.0026

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Clinically relevant inhibitors of human liver microsomal P450 enzymes, isoform CYP1A2 ChEMBL. No reference
Activity (binding) = 2.9 Inhibition of human aromatase in placental microsomes relative to aminogluthetimide ChEMBL. 18042388
Activity (binding) = 2.9 Inhibition of human aromatase in placental microsomes relative to aminogluthetimide ChEMBL. 18042388
Activity (ADMET) = 3.8 % Effect on CYP1A1/CYP1A2 in human liver assessed as 7-ethoxyresorufin O-deethylation at 100 uM relative to control ChEMBL. 17132069
Activity (ADMET) = 0 pm/min/mg Specific activity of expressed human recombinant UGT1A10 ChEMBL. 10836148
Activity (ADMET) = 0 pm/min/mg Specific activity of expressed human recombinant UGT1A7 ChEMBL. 10836148
Alpha Ki (binding) = 0.000000033 M Compound was evaluated for alpha -rate constant, in liver microsomes from 3-methylcholanthrene-exposed rats ChEMBL. 7277387
Alpha Ki (binding) = 0.000000048 M Compound was evaluated for alpha -rate constant, in liver microsomes from beta-naphthoflavone-exposed rats ChEMBL. 7277387
Cmax/SS (binding) = 3.67 uM Ratio of maximum concentration bound and specificity sum for triplex nucleic acids ChEMBL. 15509172
Displacement (binding) = 71 % Displacement of specific [125I]-AB-MECA binding from human Adenosine A3 receptor expressed in HEK-293 cells ChEMBL. 8576921
Displacement (binding) = 71 % Displacement of specific [125I]-AB-MECA binding from human Adenosine A3 receptor expressed in HEK-293 cells ChEMBL. 8576921
IC50 (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (ADMET) = 7.8 Inhibition of human recombinant CYP1A2 EROD activity expressed in Escherichia coli JM109 assessed as inhibition of de-ethylation of 7-ethoxyresorufin to resorufin by spectrofluorometric analysis ChEMBL. No reference
IC50 (binding) = 1.3 nM Inhibition of human CYP1B1 assessed as reduction in 7-ethoxyresorufin O-deethylation activity by fluorescence based EROD assay ChEMBL. 25799264
IC50 (ADMET) = 3.8 nM Inhibition of human CYP1A2 assessed as reduction in 7-ethoxyresorufin O-deethylation activity by fluorescence based EROD assay ChEMBL. 25799264
IC50 (ADMET) = 5 nM Inhibition of CYP1B1 (unknown origin) ChEMBL. 17544277
IC50 (ADMET) = 5 nM Inhibition of CYP1B1 (unknown origin) ChEMBL. 17544277
IC50 (binding) = 5 nM Inhibition of human recombinant CYP1B1 expressed in Escherichia coli membranes assessed as reduction in 7-ethoxyresorufin O-deethylation activity ChEMBL. 25799264
IC50 (ADMET) = 6 nM Inhibition of CYP1A2 (unknown origin) ChEMBL. 17544277
IC50 (ADMET) = 6 nM Inhibition of CYP1A2 (unknown origin) ChEMBL. 17544277
IC50 (ADMET) = 6 nM Inhibition of human recombinant CYP1A2 expressed in Escherichia coli membranes assessed as reduction in 7-ethoxyresorufin O-deethylation activity ChEMBL. 25799264
IC50 (ADMET) = 11.9 nM Inhibition of human CYP1A1 assessed as reduction in 7-ethoxyresorufin O-deethylation activity by fluorescence based EROD assay ChEMBL. 25799264
IC50 (ADMET) = 16 nM Inhibition of human recombinant CYP1A2 EROD activity expressed in Escherichia coli JM109 assessed as inhibition of de-ethylation of 7-ethoxyresorufin to resorufin by spectrofluorometric analysis ChEMBL. No reference
IC50 (ADMET) = 49 nM Inhibition of human CYP1A2 ChEMBL. 20832301
IC50 (ADMET) = 60 nM Inhibition of CYP1A1 (unknown origin) ChEMBL. 17544277
IC50 (ADMET) = 60 nM Inhibition of CYP1A1 (unknown origin) ChEMBL. 17544277
IC50 (ADMET) = 60 nM Inhibition of human recombinant CYP1A1 expressed in Escherichia coli membranes assessed as reduction in 7-ethoxyresorufin O-deethylation activity ChEMBL. 25799264
IC50 (binding) = 70 nM Inhibition of human placental microsome CYP19 ChEMBL. 20413308
IC50 (binding) = 0.0035 uM Inhibition of beta-napthoflavone-induced Cyp1A in rat H4II7 cell ChEMBL. 17291041
IC50 (ADMET) = 0.019 uM Inhibition of CYP1A2 (unknown origin)-mediated demethylation of resorufin methyl ether after 5 mins by spectrofluorimetric analysis ChEMBL. 23600958
IC50 (ADMET) = 0.03 uM Inhibition of recombinant human CYP1A2 by P450-Glo luminescence assay ChEMBL. 27145071
IC50 (ADMET) = 0.043 uM Inhibition of CYP1A1 (unknown origin)-mediated deethylation of resorufin ethyl ether after 5 mins by spectrofluorimetric analysis ChEMBL. 23600958
IC50 (ADMET) = 0.234 uM Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC/MS/MS method LITERATURE. 27955926
IC50 (binding) = 0.3 uM Inhibition of recombinant human CYP1B1 expressed in bacterial microsomes co-expressing P450 reductase using 7-ethyl-O-resorufin as substrate after 45 mins in presence of NADPH by fluorescence assay LITERATURE. 27687674
IC50 (binding) = 0.9909 uM DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) = 1.1325 uM DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
IC50 (binding) = 1.31 uM Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of Hoechst 33342 preincubated for 30 mins before Hoechst 33342 addition measured after 120 mins by fluorescence assay ChEMBL. 23851114
IC50 (binding) = 1.4 uM Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of pheophorbide-A preincubated for 30 mins before pheophorbide-A addition measured after 120 mins by flow cytometry ChEMBL. 23851114
IC50 (binding) = 2 uM Inhibition of human aromatase in placental microsomes ChEMBL. 18042388
IC50 (binding) = 2 uM Inhibition of human aromatase in placental microsomes ChEMBL. 18042388
IC50 (binding) = 2.3034 uM DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
IC50 (binding) = 4.98 uM Inhibition of DNA dependent protein kinase isolated from HeLa cells ChEMBL. 15658870
IC50 (binding) = 4.98 uM Inhibition of DNA dependent protein kinase isolated from HeLa cells ChEMBL. 15658870
IC50 (binding) = 5.8471 uM DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
IC50 (binding) = 6.7608 uM DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
IC50 (binding) = 11.3 uM Inhibition of MRP1 (unknown origin) expressed in human 2008 cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay ChEMBL. 23851114
IC50 (ADMET) = 13 uM Inhibition of CYP2B1 (unknown origin)-mediated depentylation of resorufin pentyl ether after 5 mins by spectrofluorimetric analysis ChEMBL. 23600958
IC50 (binding) = 24.6 uM Inhibition of p-glycoprotein (unknown origin) expressed in human A2780Adr cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay ChEMBL. 23851114
IC50 (ADMET) > 25 uM Inhibition of CYP2A6 (unknown origin)-mediated coumarin 7-hydroxylation after 5 mins by spectrofluorimetric analysis ChEMBL. 23600958
IC50 (ADMET) = 32 uM Inhibition of recombinant human CYP1A2 preincubated for 5 mins before fluorescent substrate addition by fluorescence assay ChEMBL. 24974340
IC50 (ADMET) = 32.6 uM Inhibition of human recombinant CYP1A2 incubated for 5 mins by fluorescence assay ChEMBL. 25221656
IC50 (binding) = 98.2 uM Inhibition of CYP1B1 in TCDD-stimulated human MCF7 cells assessed as inhibition of anticancer drug resistance by measuring docetaxel cytotoxic IC50 at 10 uM after 48 hrs by MTT assay (Rvb = 139.8 +/- 11.5 microM) ChEMBL. 25799264
IC50 (binding) = 110.6 uM Inhibition of CYP1B1 in TCDD-stimulated human MCF7 cells assessed as inhibition of anticancer drug resistance by measuring docetaxel cytotoxic IC50 at 5 uM after 48 hrs by MTT assay (Rvb = 139.8 +/- 11.5 microM) ChEMBL. 25799264
Inhibition (ADMET) Inhibition of human CYP2C19 at 10 uM preincubated for 10 mins with cofactor followed by mixture of enzyme-substrate addition by fluorescence assay relative to control ChEMBL. No reference
Inhibition (ADMET) Inhibition of human CYP2D6 at 10 uM preincubated for 10 mins with cofactor followed by mixture of enzyme-substrate addition by fluorescence assay relative to control ChEMBL. No reference
Inhibition (ADMET) Inhibition of CYP1B1 (unknown origin)-mediated deethylation of resorufin ethyl ether after 5 mins by spectrofluorimetric analysis ChEMBL. 23600958
Inhibition (ADMET) Inhibition of human CYP3A4 at 10 uM preincubated for 10 mins with cofactor followed by mixture of enzyme-substrate addition by fluorescence assay relative to control ChEMBL. No reference
Inhibition (ADMET) Inhibition of human CYP2C9 at 10 uM preincubated for 10 mins with cofactor followed by mixture of enzyme-substrate addition by fluorescence assay relative to control ChEMBL. No reference
Inhibition (functional) 0 % In vitro inhibitory activity of the compound against the growth of WISH cell derived from human cervical carcinoma was determined; slight effect ChEMBL. 14684314
Inhibition (ADMET) = 5.4 % Inhibition of recombinant human CYP1A2 preincubated at 10 uM for 5 mins before fluorescent substrate addition by fluorescence assay ChEMBL. 24974340
Inhibition (ADMET) > 50 % Inhibition of human recombinant CYP1A2 EROD activity expressed in Escherichia coli JM109 assessed as inhibition of de-ethylation of 7-ethoxyresorufin to resorufin at 0.3 uM by spectrofluorometric analysis ChEMBL. No reference
Inhibition (ADMET) = 84 % Inhibition of human CYP1A2 at 10 uM ChEMBL. 25244572
Inhibition (ADMET) = 87 % Inhibitory activity of 0.3 uM 7,8 benzoflavone on 69 Pmoles of cDNA-derived CYP1A2 enzyme in microsome prepared from human lymphoblastoid cell line ChEMBL. No reference
Inhibition (binding) = 89.2 % Inhibition of recombinant human CYP1B1 expressed in bacterial microsomes co-expressing P450 reductase at 3 uM using 7-ethyl-O-resorufin as substrate after 45 mins in presence of NADPH by fluorescence assay relative to control LITERATURE. 27687674
Inhibition (ADMET) = 90 % Inhibitory activity of 0.3 uM 7,8 benzoflavone on 56 Pmoles of cDNA-derived CYP1A2 enzyme in microsome prepared from human lymphoblastoid cell line ChEMBL. No reference
Inhibition (ADMET) > 93 % Inhibition of CYP1A2 at 3 uM ChEMBL. 22704887
Inhibition (ADMET) > 93 % Inhibition of human CYP1A2 at 3 uM ChEMBL. 23466233
Inhibition (ADMET) = 98 % Inhibitory activity of 0.3 uM 7,8 benzoflavone on 12.4 Pmoles of cDNA-derived CYP1A2 enzyme in microsome prepared from human lymphoblastoid cell line ChEMBL. No reference
Inhibition (ADMET) = 98.6 % Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control ChEMBL. 24900814
Inhibition (ADMET) = 99.21 % Inhibition of CYP1A2 (unknown origin) at 4 uM by luminescent readout-based method ChEMBL. 26096679
Inhibition (ADMET) = 99.21 % Inhibition of CYP1A2 (unknown origin) at 4 uM by P450-glo assay ChEMBL. 27229618
Ki (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) = 0.000000017 M Compound was evaluated for inhibition constant, in liver microsomes from 3-methylcholanthrene-exposed rats ChEMBL. 7277387
Ki (binding) = 0.000000024 M Compound was evaluated for inhibition constant, in liver microsomes from beta-naphthoflavone-exposed rats ChEMBL. 7277387
Ki (binding) = 20 nM Binding affinity of the compound was measured on Cytochrome P450 19A1 ChEMBL. 2231592
Ki (binding) = 20 nM Binding affinity of the compound was measured on Cytochrome P450 19A1 ChEMBL. 2231592
Ki (binding) = 0.016 uM Inhibition of human microsomal CYP1B1-dependent ethoxyresorufin-O-deethylase activity by spectrofluorimetric analysis in presence of NADPH regenerating solution ChEMBL. 26222195
Ki (binding) = 0.02 uM Inhibition of human microsomal CYP1A2-dependent methoxyresorufin-O-demethylase activity by spectrofluorimetric analysis in presence of NADPH regenerating solution ChEMBL. 26222195
Ki (binding) = 0.045 uM Inhibition of human microsomal CYP1A1-dependent ethoxyresorufin-O-deethylase activity by spectrofluorimetric analysis in presence of NADPH regenerating solution ChEMBL. 26222195
Ki (binding) = 0.6606 uM DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
Ki (binding) = 0.786 uM Displacement of specific [3H]-PIA binding from adenosine A1 receptor in rat brain membranes. ChEMBL. 8576921
Ki (binding) = 0.786 uM Displacement of specific [3H]-PIA binding from adenosine A1 receptor in rat brain membranes. ChEMBL. 8576921
Ki (binding) = 1.32 uM Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement. ChEMBL. 8576921
Ki (binding) = 1.32 uM Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement. ChEMBL. 8576921
Ki (binding) = 1.949 uM DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
Ki (ADMET) = 80.1 uM Mechanism based inhibition of rabbit cytochrome P450 3A6 measured by testosterone and progesterone 6-beta hydroxylation ChEMBL. 16248836
Km (binding) = 17 uM Michaelis menton constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to beta-naphthoflavone at 27.5 microM ChEMBL. 7277387
Km (binding) = 17.3 uM Michaelis menton constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to 3-methylcholanthrene at a concentration of 25 microM ChEMBL. 7277387
Km (binding) = 18.5 uM Michaelis menton constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to beta-naphthoflavone at 5 microM ChEMBL. 7277387
Km (binding) = 19.6 uM Michaelis menton constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to 3-methylcholanthrene at a concentration of 10 microM ChEMBL. 7277387
Km (binding) = 23.4 uM Michaelis menton constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to 3-methylcholanthrene at a concentration of 50 microM ChEMBL. 7277387
Km (binding) = 25.7 uM Michaelis menton constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to beta-naphthoflavone at 50 microM ChEMBL. 7277387
Log Ki (binding) = -0.12 uM Ability to displace [3H]-CGS- 21680 binding from adenosine A2A receptor. ChEMBL. 9438021
Log Ki (binding) 0 uM Ability to displace [125I]-AB-MECA binding from adenosine A3 receptor. ChEMBL. 9438021
Log Ki (binding) = 0.1 uM Ability to displace [3H]-N6-phenylisopropyladenosine binding from adenosine A1 receptor. ChEMBL. 9438021
mechanism based inhibition (ADMET) Mechanism based inhibition of human cytochrome P450 3A4 measured by testosterone 6-beta hydroxylation LITERATURE. 16248836
pKi(uM) (binding) Ability to displace [125I]-AB-MECA binding from adenosine A3 receptor. ChEMBL. 9438021
pKi(uM) (binding) = -0.12 Ability to displace [3H]-CGS- 21680 binding from adenosine A2A receptor. ChEMBL. 9438021
pKi(uM) (binding) = 0.1 Ability to displace [3H]-N6-phenylisopropyladenosine binding from adenosine A1 receptor. ChEMBL. 9438021
Potency (ADMET) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Vmax (binding) = 9.4 pM min-1 mg-1 Maximum rate constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to beta-naphthoflavone at concentration of 27.5 microM ChEMBL. 7277387
Vmax (binding) = 69 pM min-1 mg-1 Maximum rate constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to 3-methylcholanthrene at concentration of 50 microM ChEMBL. 7277387
Vmax (binding) = 108 pM min-1 mg-1 Maximum rate constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to 3-methylcholanthrene at concentration of 25 microM ChEMBL. 7277387
Vmax (binding) = 137 pM min-1 mg-1 Vmax of the compound determined by 7-ethoxycoumarin deethylation in the presence of the compound by liver microsomes from rats exposed to 3-methylcholanthrene at concentration of 10 microM ChEMBL. 7277387
Vmax (binding) = 665 pM min-1 mg-1 Maximum rate constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to beta-naphthoflavone at 50 microM ChEMBL. 7277387
Vmax (binding) = 1217 pM min-1 mg-1 Maximum rate constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to beta-naphthoflavone at 5 microM ChEMBL. 7277387

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

31 literature references were collected for this gene.

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