Detailed information for compound 557596

Basic information

Technical information
  • TDR Targets ID: 557596
  • Name: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[( 1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6 R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tet rahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]t etrahydropyran-3,4-diol; sulfuric acid
  • MW: 581.592 | Formula: C18H39N5O14S
  • H donors: 13 H acceptors: 10 LogP: -10.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: OS(=O)(=O)O.OC[C@H]1O[C@H](O[C@H]2[C@H](N)C[C@@H]([C@H]([C@@H]2O)O[C@H]2O[C@H](CN)[C@H]([C@@H]([C@H]2N)O)O)N)[C@@H]([C@H]([C@@H]1O)N)O
  • InChi: 1S/C18H37N5O10.H2O4S/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18;1-5(2,3)4/h4-18,24-29H,1-3,19-23H2;(H2,1,2,3,4)/t4-,5+,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+;/m0./s1
  • InChiKey: YGTPKDKJVZOVCO-KELBJJLKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-2-hydroxycyclohexoxy]tetrahydropyran-3,4-diol; sulfuric acid
  • (2R,3S,4R,5R,6R)-2-(aminomethyl)-5-azanyl-6-[(1R,2S,3S,4R,6S)-4,6-bis(azanyl)-3-[(2S,3R,4S,5S,6R)-4-azanyl-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; sulfuric acid
  • (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol; sulfuric acid
  • (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4-diol; sulfuric acid
  • bekanamycin
  • (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; sulfuric acid
  • Kanendomycin
  • Kanendomycin (TN)
  • 60616_FLUKA
  • Bekanamycin sulfate salt
  • Kanamycin B sulfate salt
  • SPECTRUM1500812
  • B5264_SIGMA
  • (1R,2S,3S,4R,6S)-4,6-diamino-3-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside sulfate
  • CHEBI:31255
  • AKM
  • Bekanamycin sulfate
  • Bekanamycin sulfate (JP15)
  • D01868

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock 27kDa protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi small heat shock protein Get druggable targets OG5_141248 All targets in OG5_141248
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141248 All targets in OG5_141248
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hsp20/alpha crystallin family protein heat shock 27kDa protein 1 205 aa 168 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0052 0.0063
Loa Loa (eye worm) hypothetical protein 0.0131 0.0246 0.0297
Onchocerca volvulus 0.0114 0.0204 0.0859
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0096 0.0329
Brugia malayi Isocitrate dehydrogenase 0.0371 0.0821 0.0994
Loa Loa (eye worm) MH1 domain-containing protein 0.0234 0.0493 0.0598
Echinococcus granulosus expressed protein 0.0368 0.0814 0.1629
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0039 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.0048 0.0045 0.0079
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0183 0.0369 0.1271
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0005 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0052 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0115 0.0278
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0087 0.0139 0.2039
Brugia malayi topoisomerase 0.008 0.0123 0.0148
Echinococcus multilocularis expressed conserved protein 0.0184 0.0372 0.0372
Loa Loa (eye worm) IMP dehydrogenase 1 0.0183 0.0369 0.0447
Toxoplasma gondii hypothetical protein 0.0087 0.0138 0.0476
Plasmodium vivax thioredoxin reductase, putative 0.0251 0.0533 0.1822
Mycobacterium ulcerans proteasome PrcA 0.0243 0.0515 0.1773
Mycobacterium ulcerans lipase LipD 0.0077 0.0115 0.0396
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0243 0.0515 0.0916
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0052 0.0093
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1097 0.2565 0.2565
Brugia malayi glutathione reductase 0.0251 0.0533 0.0646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0052 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0137 0.0454
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0069 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0096 0.0191
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Leishmania major proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0243 0.0515 0.1757
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0006 0.0006
Brugia malayi nuclear receptor NHR-88 0.0051 0.0052 0.0063
Leishmania major proteasome alpha 2 subunit, putative 0.0243 0.0515 0.1773
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.0139 0.048
Brugia malayi mbt repeat family protein 0.0051 0.0052 0.0063
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0053 0.0182
Brugia malayi MH1 domain containing protein 0.0234 0.0493 0.0598
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0243 0.0515 0.1773
Schistosoma mansoni kinase 0.0142 0.0272 0.0483
Brugia malayi TAR-binding protein 0.0902 0.2096 0.2539
Schistosoma mansoni hypothetical protein 0.0081 0.0125 0.0222
Trypanosoma brucei pol-associated gene 1 0.0056 0.0066 0.0226
Trypanosoma cruzi polo-like protein kinase, putative 0.0279 0.0601 0.2069
Brugia malayi steroid hormone receptor 0.0051 0.0052 0.0063
Schistosoma mansoni hypothetical protein 0.1097 0.2565 0.4562
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0378 0.0837 0.1488
Trypanosoma cruzi 20S proteasome subunit 0.0596 0.1362 0.469
Plasmodium falciparum endoplasmic reticulum oxidoreductin, putative 0.0056 0.0066 0.0208
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0052 0.0104
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0132 0.0132
Echinococcus granulosus mothers against decapentaplegic 5 0.0234 0.0493 0.0987
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0052 0.0093
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0243 0.0515 0.0515
Leishmania major inosine-5-monophosphate dehydrogenase 0.0183 0.0369 0.1271
Brugia malayi jmjC domain containing protein 0.0043 0.0033 0.004
Loa Loa (eye worm) hypothetical protein 0.0086 0.0137 0.0166
Toxoplasma gondii isocitrate dehydrogenase 0.0371 0.0821 0.2825
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0234 0.0493 0.0877
Trypanosoma cruzi hypothetical protein, conserved 0.0422 0.0943 0.3246
Plasmodium falciparum methionine--tRNA ligase, putative 0.0086 0.0137 0.0454
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0035 0.0121
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Schistosoma mansoni intermediate filament proteins 0.0033 0.0009 0.0015
Echinococcus multilocularis lamin 0.0033 0.0009 0.0009
Echinococcus granulosus mothers against decapentaplegic 6 0.0105 0.0182 0.0364
Loa Loa (eye worm) transcription factor SMAD2 0.3442 0.8191 0.9922
Giardia lamblia Proteasome subunit beta type 3 0.0243 0.0515 0.1757
Toxoplasma gondii proteasome subunit alpha type, putative 0.0243 0.0515 0.1773
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0115 0.0278
Toxoplasma gondii hypothetical protein 0.0039 0.0024 0.0081
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0371 0.0821 0.2825
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0069 0.0069
Schistosoma mansoni smad1 5 8 and 0.0234 0.0493 0.0877
Brugia malayi nuclear hormone receptor 0.0051 0.0052 0.0063
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0596 0.1362 0.469
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0251 0.0533 0.1821
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0045 0.0039 0.0047
Loa Loa (eye worm) hypothetical protein 0.3469 0.8256 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0123 0.0422
Plasmodium vivax proteasome subunit beta type-7, putative 0.0243 0.0515 0.1757
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0226 0.0472 0.1625
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0043 0.0052
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0045 0.0039 0.0077
Giardia lamblia 20S proteasome alpha subunit 5 0.0243 0.0515 0.1757
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0243 0.0515 0.0624
Echinococcus multilocularis tar DNA binding protein 0.0902 0.2096 0.2096
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0243 0.0515 0.1757
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0087 0.0139 0.2039
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0243 0.0515 0.1757
Brugia malayi Pre-SET motif family protein 0.0127 0.0234 0.0284
Schistosoma mansoni hypothetical protein 0.2371 0.5621 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0872 0.2023 0.245
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0596 0.1362 0.469
Brugia malayi Smad1 0.0234 0.0493 0.0598
Toxoplasma gondii proteasome subunit 0.0243 0.0515 0.1773
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0087 0.0139 0.048
Trypanosoma cruzi PAB1-binding protein , putative 0.0345 0.0758 0.261
Onchocerca volvulus Serine\/threonine kinase homolog 0.0279 0.0601 0.2582
Trypanosoma cruzi endoplasmic reticulum oxidoreductin, putative 0.0056 0.0066 0.0226
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0035 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0035 0.0121
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0115 0.023
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Brugia malayi MH2 domain containing protein 0.0105 0.0182 0.022
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0035 0.0121
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0087 0.0139 0.048
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0052 0.0104
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0637 0.146 0.5025
Giardia lamblia 20S proteasome alpha subunit 1 0.0243 0.0515 0.1757
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0243 0.0515 0.0916
Giardia lamblia Leucyl-tRNA synthetase 0.0086 0.0137 0.0454
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0371 0.0821 0.146
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0243 0.0515 0.1773
Brugia malayi hypothetical protein 0.0036 0.0017 0.002
Loa Loa (eye worm) proteasome subunit beta type 1 0.0963 0.2241 0.2714
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0243 0.0515 0.1757
Schistosoma mansoni hypothetical protein 0.1097 0.2565 0.4562
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0243 0.0515 0.0916
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0087 0.0139 0.0462
Schistosoma mansoni dep domain containing protein 0.0039 0.0024 0.0042
Echinococcus granulosus peregrin 0.0031 0.0005 0.0011
Brugia malayi GMP reductase 0.0079 0.0119 0.0145
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Loa Loa (eye worm) MBCTL1 0.0058 0.0069 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0052 0.0063
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0155 0.0302 0.0604
Echinococcus multilocularis peptidase Clp (S14 family) 0.0165 0.0326 0.0326
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.007 0.0098 0.0339
Echinococcus multilocularis expressed protein 0.0368 0.0814 0.0814
Leishmania major proteasome alpha 1 subunit, putative 0.0243 0.0515 0.1773
Giardia lamblia 20S proteasome alpha subunit 6 0.0243 0.0515 0.1757
Schistosoma mansoni Smad4 0.0105 0.0182 0.0324
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0183 0.0369 0.1271
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0573 0.1306 0.4497
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0243 0.0515 0.1757
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0138 0.0458
Brugia malayi Probable ClpP-like protease 0.0251 0.0533 0.0646
Brugia malayi proteasome subunit beta type 2 0.0596 0.1362 0.165
Trypanosoma brucei cytochrome P450, putative 0.0047 0.0043 0.0148
Toxoplasma gondii proteasome subunit beta type, putative 0.1239 0.2904 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0119
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.049 0.0981
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0009 0.001
Giardia lamblia 20S proteasome alpha subunit 3 0.0243 0.0515 0.1757
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0243 0.0515 0.1773
Echinococcus granulosus proteasome subunit alpha type 2 0.0243 0.0515 0.103
Trypanosoma brucei GMP reductase 0.0183 0.0369 0.1271
Brugia malayi MH1 domain containing protein 0.013 0.0242 0.0293
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0176 0.0176
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0039 0.0024 0.0024
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0064 0.0084 0.0102
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0052 0.0092
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0279 0.0601 0.0601
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0596 0.1362 0.1362
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0378 0.0837 0.0837
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1239 0.2904 1
Echinococcus multilocularis microtubule associated protein 2 0.2111 0.4998 0.4998
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1239 0.2904 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0115 0.0278
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0243 0.0515 0.0515
Schistosoma mansoni tar DNA-binding protein 0.0902 0.2096 0.3729
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0087 0.0139 0.048
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0053 0.0163
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0045 0.0039 0.0039
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0243 0.0515 0.1724
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0052 0.0052
Brugia malayi proteasome subunit alpha type 4 0.0243 0.0515 0.0624
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0596 0.1362 0.2423
Schistosoma mansoni unc-13 (munc13) 0.0045 0.0039 0.0069
Loa Loa (eye worm) glutathione reductase 0.0251 0.0533 0.0646
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243 0.0515 0.0515
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.0551 0.0667
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0094 0.0155 0.0535
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0052 0.0093
Mycobacterium ulcerans hypothetical protein 0.0077 0.0115 0.0396
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0115 0.0205
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0052 0.0104
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0165 0.0326 0.1121
Echinococcus granulosus proteasome subunit beta type 7 0.0243 0.0515 0.103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0052 0.0063
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.008 0.0123 0.0148
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0371 0.0821 0.0821
Brugia malayi Latrophilin receptor protein 2 0.1097 0.2565 0.3106
Schistosoma mansoni Smad4 0.0234 0.0493 0.0877
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0196 0.04 0.1327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0052 0.0063
Entamoeba histolytica tartrate dehydrogenase, putative 0.0045 0.0039 0.0075
Mycobacterium tuberculosis Conserved protein 0.0077 0.0115 0.0396
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0087 0.0139 0.048
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0338 0.1441
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0155 0.0535
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0105 0.0182 0.0766
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0279 0.0601 0.1202
Plasmodium falciparum replication factor C subunit 1, putative 0.008 0.0123 0.0404
Echinococcus multilocularis tumor protein p63 0.0334 0.0732 0.0732
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0052 0.0052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0096 0.0329
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0035 0.0035
Trypanosoma brucei PAB1-binding protein , putative 0.0345 0.0758 0.261
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0052 0.0201
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0378 0.0837 0.0837
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0371 0.0821 0.2825
Leishmania major hypothetical protein, conserved 0.0345 0.0758 0.261
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0963 0.2241 0.7702
Schistosoma mansoni alpha-glucosidase 0.0169 0.0337 0.0599
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0243 0.0515 0.0916
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0053 0.0182
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0183 0.0369 0.1271
Echinococcus granulosus GPCR family 2 0.1097 0.2565 0.5132
Loa Loa (eye worm) beta-lactamase 0.0077 0.0115 0.0139
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0052 0.0063
Schistosoma mansoni dishevelled 0.0039 0.0024 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0052 0.0063
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0083 0.013 0.0449
Echinococcus granulosus Pleckstrin G protein interacting region 0.0039 0.0024 0.0047
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0371 0.0821 0.2825
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.008 0.0123 0.0422
Plasmodium vivax proteasome subunit beta type-1, putative 0.0963 0.2241 0.7712
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0243 0.0515 0.1671
Loa Loa (eye worm) hypothetical protein 0.0251 0.0533 0.0646
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0087 0.0139 0.0248
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0053 0.0061
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0234 0.0493 0.0493
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Echinococcus granulosus tumor protein p63 0.0334 0.0732 0.1464
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0096 0.0329
Schistosoma mansoni lamin 0.0033 0.0009 0.0015
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0243 0.0515 0.1724
Brugia malayi CHE-14 protein 0.0084 0.0132 0.016
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.008 0.0123 0.0304
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0033 0.0066
Schistosoma mansoni lamin 0.0033 0.0009 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0052 0.0104
Echinococcus granulosus proteasome prosome macropain 0.1239 0.2904 0.5812
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0243 0.0515 0.1773
Leishmania major hypothetical protein, conserved 0.0077 0.0115 0.0396
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0183 0.0369 0.0657
Onchocerca volvulus Putative GMP reductase 0.0079 0.0119 0.0495
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0243 0.0515 0.1724
Loa Loa (eye worm) hypothetical protein 0.0131 0.0246 0.0297
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.008 0.0123 0.1698
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0115 0.0396
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0039 0.0024 0.0078
Trichomonas vaginalis mercuric reductase, putative 0.0087 0.0139 0.0363
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0243 0.0515 0.1757
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0052 0.0063
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0243 0.0515 0.0916
Schistosoma mansoni z-protein (S1r protein) 0.0058 0.0069 0.0123
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0094 0.0155 0.0535
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243 0.0515 0.0515
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0243 0.0515 0.1757
Brugia malayi DIX domain containing protein 0.0039 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0788 0.1821 0.7875
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Loa Loa (eye worm) MH2 domain-containing protein 0.0105 0.0182 0.022
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0243 0.0515 0.0916
Brugia malayi RNA binding protein 0.0902 0.2096 0.2539
Schistosoma mansoni ero1-related 0.0056 0.0066 0.0117
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0251 0.0533 0.1836
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0069 0.0122
Onchocerca volvulus 0.0032 0.0006 0.0004
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0132 0.016
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0243 0.0515 0.0624
Schistosoma mansoni dishevelled 0.0039 0.0024 0.0042
Loa Loa (eye worm) isocitrate dehydrogenase 0.0371 0.0821 0.0994
Trypanosoma cruzi polo-like protein kinase, putative 0.0279 0.0601 0.2069
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0123 0.0304
Echinococcus granulosus dnaJ subfamily B 0.1236 0.2898 0.5798
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0155 0.0535
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0087 0.0139 0.048
Loa Loa (eye worm) thioredoxin reductase 0.0251 0.0533 0.0646
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0119
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.3469 0.8256 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0155 0.0535
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0052 0.0063
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0086 0.0137 0.0472
Echinococcus multilocularis methionine tRNA synthetase 0.0226 0.0472 0.0472
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0251 0.0533 0.0533
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0243 0.0515 0.1724
Schistosoma mansoni peptidase Clp (S14 family) 0.0251 0.0533 0.0949
Plasmodium falciparum glutathione reductase 0.0251 0.0533 0.1822
Leishmania major proteasome beta 5 subunit, putative 0.1239 0.2904 1
Schistosoma mansoni smad1 5 8 and 0.0234 0.0493 0.0877
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0378 0.0837 0.1674
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0226 0.0472 0.0572
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0243 0.0515 0.0916
Giardia lamblia 20S proteasome alpha subunit 4 0.0243 0.0515 0.1757
Onchocerca volvulus Notchless protein homolog 0.0243 0.0515 0.2209
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0052 0.0104
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0053 0.0061
Onchocerca volvulus 0.0033 0.0009 0.0014
Leishmania major methionyl-tRNA synthetase, putative 0.0226 0.0472 0.1625
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Loa Loa (eye worm) hypothetical protein 0.0054 0.0059 0.0071
Loa Loa (eye worm) hypothetical protein 0.0086 0.0137 0.0166
Onchocerca volvulus 0.0033 0.0009 0.0014
Mycobacterium leprae Probable lipase LipE 0.0077 0.0115 0.0396
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0052 0.0063
Echinococcus granulosus methionine tRNA synthetase 0.0226 0.0472 0.0944
Echinococcus granulosus Niemann Pick C1 protein 0.0196 0.04 0.0801
Toxoplasma gondii heat shock protein hslv, putative 0.0243 0.0515 0.1773
Brugia malayi protein ZK524.3 0.0086 0.0137 0.0166
Loa Loa (eye worm) hypothetical protein 0.0045 0.0039 0.0047
Onchocerca volvulus 0.0049 0.0048 0.0183
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0115 0.0396
Echinococcus granulosus Endoplasmic reticulum oxidoreductin 1 0.0056 0.0066 0.0131
Loa Loa (eye worm) hypothetical protein 0.0788 0.1821 0.2206
Onchocerca volvulus 0.0051 0.0052 0.0203
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.01 0.0169 0.0583
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0052 0.0052
Trypanosoma brucei proteasome beta 7 subunit 0.0243 0.0515 0.1773
Toxoplasma gondii proteasome beta subunit 0.0243 0.0515 0.1773
Echinococcus granulosus proteasome subunit alpha type 6 0.0243 0.0515 0.103
Echinococcus granulosus thioredoxin glutathione reductase 0.0253 0.0537 0.1075
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.1097 0.2565 0.2565
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1239 0.2904 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0119
Plasmodium falciparum methionine--tRNA ligase 0.0226 0.0472 0.1609
Treponema pallidum leucyl-tRNA synthetase 0.0086 0.0137 0.0355
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0035 0.0043
Schistosoma mansoni hypothetical protein 0.0081 0.0125 0.0222
Echinococcus multilocularis proteasome subunit alpha type 2 0.0243 0.0515 0.0515
Brugia malayi Proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0963 0.2241 0.4484
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0243 0.0515 0.0916
Trypanosoma brucei proteasome alpha 7 subunit 0.0243 0.0515 0.1773
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1239 0.2904 0.5167
Toxoplasma gondii proteasome subunit alpha1, putative 0.0243 0.0515 0.1773
Leishmania major proteasome beta 2 subunit, putative 0.0243 0.0515 0.1773
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0053 0.0106
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0005 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0052 0.0063
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1239 0.2904 1
Echinococcus multilocularis citrate lyase subunit beta protein 0.0049 0.0047 0.0047
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0243 0.0515 0.1724
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0243 0.0515 0.1757
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0069 0.0083
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0178 0.0358 0.1217
Echinococcus granulosus Proteasome subunit alpha type 7 0.0243 0.0515 0.103
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0371 0.0821 0.0821
Echinococcus granulosus geminin 0.0725 0.1672 0.3345
Brugia malayi Proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0139 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Onchocerca volvulus 0.008 0.0123 0.0508
Mycobacterium ulcerans hypothetical protein 0.0049 0.0047 0.0162
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0115 0.0378
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0637 0.146 0.5025
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0005 0.001
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0045 0.0039 0.0133
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0243 0.0515 0.1757
Schistosoma mansoni isocitrate dehydrogenase 0.0045 0.0039 0.0069
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0245 0.0518 0.1736
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Schistosoma mansoni Smad4 0.0105 0.0182 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0052 0.0063
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 1
Plasmodium falciparum acyl-CoA synthetase 0.007 0.0098 0.0321
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0052 0.0104
Leishmania major proteasome beta 3 subunit, putative 0.0243 0.0515 0.1773
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0049 0.0047 0.0041
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0005 0.0019
Brugia malayi Cytochrome P450 family protein 0.0047 0.0043 0.0052
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0251 0.0533 0.1067
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0725 0.1672 0.2974
Loa Loa (eye worm) hypothetical protein 0.0058 0.0069 0.0083
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0045 0.0039 0.0133
Mycobacterium tuberculosis Probable oxidoreductase 0.0637 0.146 0.5025
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0086 0.0137 0.1993
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0115 0.0396
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0243 0.0515 0.1757
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0052 0.0203
Loa Loa (eye worm) hypothetical protein 0.0698 0.1605 0.1944
Brugia malayi N-terminal motif family protein 0.0788 0.1821 0.2206
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Brugia malayi 20S proteasome alpha5 subunit 0.0243 0.0515 0.0624
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0119
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0087 0.0139 0.0462
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0069 0.0137
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0176 0.0352
Loa Loa (eye worm) hypothetical protein 0.0127 0.0234 0.0284
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0243 0.0515 0.1724
Trypanosoma cruzi FHA domain containing protein, putative 0.008 0.0123 0.0422
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0105 0.0182 0.022
Echinococcus granulosus subfamily T1A non peptidase ue 0.0243 0.0515 0.103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0052 0.0104
Loa Loa (eye worm) RNA binding protein 0.0902 0.2096 0.2539
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0243 0.0515 0.1724
Echinococcus granulosus peptidase Clp S14 family 0.0165 0.0326 0.0652
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0243 0.0515 0.0916
Mycobacterium ulcerans proteasome PrcB 0.1239 0.2904 1
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0079 0.0119 0.0145
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0087 0.0139 0.048
Plasmodium vivax proteasome subunit beta type-4, putative 0.0243 0.0515 0.1757
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0094 0.0155 0.0535
Plasmodium vivax replication factor C subunit 1, putative 0.008 0.0123 0.0404
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0052 0.0052
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0079
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0243 0.0515 0.1724
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0069 0.0069
Giardia lamblia Methionyl-tRNA synthetase 0.0226 0.0472 0.1609
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.012 0.0219 0.0438
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Loa Loa (eye worm) MH1 domain-containing protein 0.0105 0.0182 0.022
Plasmodium vivax methionine--tRNA ligase, putative 0.0226 0.0472 0.1609
Onchocerca volvulus 0.0077 0.0115 0.0476
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0243 0.0515 0.1671
Leishmania major proteasome beta 2 subunit, putative 0.0596 0.1362 0.469
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0115 0.0396
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0053 0.0061
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0087 0.0139 0.048
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0243 0.0515 0.1757
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.008 0.0123 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.0422 0.0943 0.3246
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0183 0.0369 0.0369
Trypanosoma brucei glucosidase, putative 0.0044 0.0035 0.0121
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0637 0.146 0.5025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0052 0.0063
Leishmania major proteasome beta 7 subunit, putative 0.0243 0.0515 0.1773
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0053 0.0182
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Brugia malayi beta-lactamase family protein 0.0077 0.0115 0.0139
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.1097 0.2565 0.4562
Loa Loa (eye worm) pigment dispersing factor receptor c 0.3469 0.8256 1
Schistosoma mansoni chromosome transmission fidelity factor 0.008 0.0123 0.0218
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0028
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0226 0.0472 0.1522
Loa Loa (eye worm) hypothetical protein 0.0084 0.0132 0.016
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0053 0.0182
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0378 0.0837 0.1013
Brugia malayi Probable isocitrate dehydrogenase 0.0045 0.0039 0.0047
Loa Loa (eye worm) CYP4Cod1 0.0047 0.0043 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0009
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0087 0.0139 0.0279
Echinococcus multilocularis GPCR, family 2 0.1097 0.2565 0.2565
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243 0.0515 0.0515
Schistosoma mansoni methionine-tRNA synthetase 0.0226 0.0472 0.0839
Brugia malayi beta-lactamase 0.0077 0.0115 0.0139
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0165 0.0326 0.1121
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0053 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.0601 0.1069
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0096 0.0329
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0243 0.0515 0.0515
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0052 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0493 0.0598
Echinococcus multilocularis nibrin 0.008 0.0123 0.0123
Schistosoma mansoni microtubule-associated protein tau 0.2111 0.4998 0.889
Onchocerca volvulus 0.0048 0.0045 0.017
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0243 0.0515 0.1773
Brugia malayi Calcitonin receptor-like protein seb-1 0.3469 0.8256 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0045 0.0079
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0183 0.0369 0.1271
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0378 0.0837 0.1013
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0226 0.0472 0.1625
Echinococcus multilocularis proteasome subunit alpha type 6 0.0243 0.0515 0.0515
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 1
Toxoplasma gondii endoplasmic reticulum oxidoreductin, putative 0.0056 0.0066 0.0226
Entamoeba histolytica hypothetical protein 0.008 0.0123 0.0366
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0052 0.0063
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0243 0.0515 0.0624
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0033 0.0059
Brugia malayi latrophilin 2 splice variant baaae 0.2371 0.5621 0.6809
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1239 0.2904 1
Brugia malayi MH2 domain containing protein 0.0234 0.0493 0.0598
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1097 0.2565 0.5132
Brugia malayi Cytochrome P450 family protein 0.0047 0.0043 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0422 0.0943 0.3246
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Brugia malayi Niemann-Pick C1 protein precursor 0.0196 0.04 0.0485
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0243 0.0515 0.1724
Brugia malayi PHD-finger family protein 0.0031 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.013 0.0242 0.0293
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.1097 0.2565 0.3106
Brugia malayi proteasome subunit alpha type 6 0.0243 0.0515 0.0624
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0183 0.0369 0.1271
Schistosoma mansoni smad 0.0234 0.0493 0.0877
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Echinococcus granulosus expressed conserved protein 0.0184 0.0372 0.0744
Leishmania major isocitrate dehydrogenase, putative 0.0045 0.0039 0.0133
Trypanosoma brucei trypanothione reductase 0.0251 0.0533 0.1837
Echinococcus multilocularis replication factor c subunit 1 0.008 0.0123 0.0123
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0047 0.0162
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0053 0.0064
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0189 0.0383 0.0682
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0187 0.0227
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0115 0.0396
Leishmania major proteasome alpha 1 subunit, putative 0.0243 0.0515 0.1773
Brugia malayi hypothetical protein 0.008 0.0123 0.0148
Brugia malayi CXXC zinc finger family protein 0.0087 0.0139 0.0168
Schistosoma mansoni topbp1 0.008 0.0123 0.0218
Schistosoma mansoni patched 1 0.0084 0.0132 0.0235
Echinococcus granulosus proteasome subunit beta t family 0.0243 0.0515 0.103
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0043 0.0148
Chlamydia trachomatis leucine--tRNA ligase 0.0086 0.0137 0.089
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0035 0.0043
Leishmania major guanosine monophosphate reductase 0.0183 0.0369 0.1271
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0115 0.0396
Echinococcus granulosus tm gpcr rhodopsin 0.0566 0.1289 0.2579
Brugia malayi MH2 domain containing protein 0.0234 0.0493 0.0598
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0183 0.0369 0.6681
Mycobacterium tuberculosis Probable reductase 0.0573 0.1306 0.4497
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0963 0.2241 0.7712
Trichomonas vaginalis replication factor C large subunit, putative 0.008 0.0123 0.0304
Plasmodium falciparum proteasome subunit beta type-4 0.0243 0.0515 0.1757
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0094 0.0155 0.0535
Brugia malayi methionyl-tRNA synthetase 0.0086 0.0137 0.0166
Toxoplasma gondii peptidase, T1 family protein 0.0243 0.0515 0.1773
Schistosoma mansoni cpg binding protein 0.0092 0.0151 0.0268
Brugia malayi Proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Leishmania major leucyl-tRNA synthetase, putative 0.0086 0.0137 0.0472
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0005 0.0011
Brugia malayi Pax transcription activation domain interacting protein 0.008 0.0123 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0115 0.0396
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0045 0.0039 0.0047
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0243 0.0515 0.1757
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.003 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0123 0.0304
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0243 0.0515 0.1773
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0052 0.0104
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0083 0.013 0.0449
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0243 0.0515 0.0515
Mycobacterium tuberculosis Conserved protein 0.0049 0.0047 0.0162
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0243 0.0515 0.1757
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0243 0.0515 0.1773
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0403 0.0403
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0035 0.0064
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0183 0.0369 0.0447
Plasmodium vivax proteasome subunit beta type-3, putative 0.0243 0.0515 0.1757
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0251 0.0533 0.1837
Giardia lamblia Replication factor C, subunit 1 0.008 0.0123 0.0404
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0243 0.0515 0.1773
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Echinococcus granulosus mothers against decapentaplegic 2 0.0105 0.0182 0.0364
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0087 0.0139 0.0462
Echinococcus multilocularis geminin 0.0725 0.1672 0.1672
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0052 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0378 0.0837 0.1674
Brugia malayi hypothetical protein 0.0131 0.0246 0.0297
Trypanosoma cruzi trypanothione reductase, putative 0.0251 0.0533 0.1837
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0243 0.0515 0.1773
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0049 0.0047 0.0162
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0018 0.0032
Echinococcus granulosus segment polarity protein dishevelled 0.0039 0.0024 0.0047
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0243 0.0515 0.0916
Echinococcus granulosus microtubule associated protein 2 0.2111 0.4998 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Entamoeba histolytica serine/threonine protein kinase, putative 0.0279 0.0601 0.2022
Plasmodium vivax ataxin-2 like protein, putative 0.0345 0.0758 0.2596
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0226 0.0472 0.1625
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.008 0.0123 0.0422
Brugia malayi small heat shock protein 0.0698 0.1605 0.1944
Plasmodium falciparum glutathione reductase 0.0087 0.0139 0.0462
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0087 0.0139 0.048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0052 0.0063
Echinococcus multilocularis mothers against decapentaplegic 2 0.0105 0.0182 0.0182
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0243 0.0515 0.1773
Onchocerca volvulus 0.0077 0.0115 0.0476
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Mycobacterium ulcerans hypothetical protein 0.0049 0.0047 0.0162
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0155 0.0188
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0226 0.0472 0.1625
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0039 0.0024 0.0042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0052 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0155 0.0188
Loa Loa (eye worm) PAS-3 protein 0.0243 0.0515 0.0624
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0115 0.0396
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0566 0.1289 0.1289
Trichomonas vaginalis esterase, putative 0.0077 0.0115 0.0278
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0243 0.0515 0.1757
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0378 0.0837 0.1488
Onchocerca volvulus Huntingtin homolog 0.0131 0.0246 0.1041
Plasmodium vivax glutathione reductase, putative 0.0251 0.0533 0.1822
Brugia malayi hypothetical protein 0.0039 0.0024 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0115 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0123 0.0422
Schistosoma mansoni hypothetical protein 0.0081 0.0125 0.0222
Schistosoma mansoni tar DNA-binding protein 0.0902 0.2096 0.3729
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0243 0.0515 0.1773
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0096 0.017
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0243 0.0515 0.1671
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.001
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0243 0.0515 0.1757
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0243 0.0515 0.1724
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0052 0.0063
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0243 0.0515 0.1757
Loa Loa (eye worm) hypothetical protein 0.0049 0.0048 0.0058
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.001
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0963 0.2241 0.2241
Echinococcus multilocularis Niemann Pick C1 protein 0.0196 0.04 0.04
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0243 0.0515 0.1773
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0155 0.0188
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0573 0.1306 0.4497
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0596 0.1362 0.4659
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0045 0.0039 0.0012
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0243 0.0515 0.1773
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0053 0.0106
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0226 0.0472 0.8759
Loa Loa (eye worm) MH2 domain-containing protein 0.3442 0.8191 0.9922
Chlamydia trachomatis DNA ligase 0.008 0.0123 0.0555
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0243 0.0515 0.103
Echinococcus multilocularis proteasome subunit beta type 7 0.0243 0.0515 0.0515
Echinococcus granulosus Niemann Pick C1 protein 0.028 0.0602 0.1204
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0028
Onchocerca volvulus Huntingtin homolog 0.0131 0.0246 0.1041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0052 0.0093
Loa Loa (eye worm) latrophilin receptor protein 2 0.1097 0.2565 0.3106
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0596 0.1362 0.2423
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0243 0.0515 0.1724
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0089 0.0307
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0132 0.0264
Schistosoma mansoni DNA ligase IV 0.008 0.0123 0.0218
Brugia malayi proteasome subunit beta type 3 0.0243 0.0515 0.0624
Echinococcus granulosus lamin dm0 0.0033 0.0009 0.0017
Brugia malayi MH1 domain containing protein 0.013 0.0242 0.0293
Echinococcus multilocularis Niemann Pick C1 protein 0.028 0.0602 0.0602
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0052 0.0063
Toxoplasma gondii tRNA ligases class I (M) protein 0.0086 0.0137 0.0472
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0243 0.0515 0.1773
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.0551 0.0667
Echinococcus multilocularis segment polarity protein dishevelled 0.0039 0.0024 0.0024
Plasmodium vivax proteasome subunit beta type-5, putative 0.1239 0.2904 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0089 0.0307
Toxoplasma gondii LsmAD domain-containing protein 0.0345 0.0758 0.261
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.0155 0.0479
Loa Loa (eye worm) hypothetical protein 0.0103 0.0177 0.0215
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0089 0.0307
Leishmania major trypanothione reductase 0.0251 0.0533 0.1837
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.008 0.0123 0.0304
Giardia lamblia Proteasome subunit beta type 2 0.0596 0.1362 0.468
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0492 0.111 0.3823
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0243 0.0515 0.103
Mycobacterium tuberculosis Probable dehydrogenase 0.0573 0.1306 0.4497
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0138 0.0379
Loa Loa (eye worm) hypothetical protein 0.1097 0.2565 0.3106
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0243 0.0515 0.1773
Echinococcus multilocularis leucyl tRNA synthetase 0.0086 0.0137 0.0137
Brugia malayi Thioredoxin reductase 0.0251 0.0533 0.0646
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0243 0.0515 0.0916
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0052 0.0093
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0243 0.0515 0.1773
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Echinococcus multilocularis protein dispatched 1 0.0096 0.0161 0.0161
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0035 0.0071
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0115 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0115 0.0396
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0178 0.0358 0.1234
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0009 0.001
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0963 0.2241 0.7716
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0251 0.0533 0.1836
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0243 0.0515 0.1773
Echinococcus granulosus tar DNA binding protein 0.0902 0.2096 0.4194
Plasmodium vivax proteasome subunit beta type-2, putative 0.0596 0.1362 0.468
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0115 0.0396
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0243 0.0515 0.1773
Schistosoma mansoni hypothetical protein 0.0725 0.1672 0.2974
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0596 0.1362 0.2725
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.0263 0.0793
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.0263 0.0793
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0035 0.007
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0243 0.0515 0.1773
Trichomonas vaginalis set domain proteins, putative 0.0992 0.2311 0.7932
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0115 0.0115
Brugia malayi Pre-SET motif family protein 0.0872 0.2023 0.245
Plasmodium vivax proteasome subunit beta type-6, putative 0.0243 0.0515 0.1757
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0115 0.0396
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0243 0.0515 0.1724
Brugia malayi RNA recognition motif domain containing protein 0.0902 0.2096 0.2539
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0096 0.0329
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0371 0.0821 0.0821
Echinococcus granulosus segment polarity protein dishevelled 0.0039 0.0024 0.0047
Brugia malayi DKFZp564C0469 protein 0.008 0.0123 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0132 0.0337
Treponema pallidum NADH oxidase 0.0087 0.0139 0.041
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0094 0.0155 0.0535
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0138 0.0458
Brugia malayi mbt repeat family protein 0.0051 0.0052 0.0063
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0371 0.0821 0.2825
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0045 0.0039 0.0077
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0086 0.0137 0.0416
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0596 0.1362 0.4625
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0053 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.036 0.113
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0403 0.0403
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0243 0.0515 0.0916
Loa Loa (eye worm) nuclear factor I 0.013 0.0242 0.0293
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0045 0.0039 0.0047
Giardia lamblia Proteasome subunit beta type 1 0.0963 0.2241 0.7712
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0085 0.0103
Plasmodium vivax acyl-CoA synthetase, putative 0.007 0.0098 0.0321
Echinococcus granulosus lamin 0.0033 0.0009 0.0017
Mycobacterium ulcerans hypothetical protein 0.0094 0.0155 0.0535
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0087 0.0139 0.048
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0086 0.0137 0.0137
Echinococcus multilocularis segment polarity protein dishevelled 0.0039 0.0024 0.0024
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0053 0.0182
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0047 0.0043 0.0148
Chlamydia trachomatis methionine--tRNA ligase 0.0086 0.0137 0.089
Echinococcus multilocularis musashi 0.0033 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.2371 0.5621 0.6809
Echinococcus multilocularis proteasome (prosome, macropain) 0.1239 0.2904 0.2904
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0403 0.0806
Schistosoma mansoni smad 0.0105 0.0182 0.0324
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0155 0.0302 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0123 0.0304
Giardia lamblia 20S proteasome alpha subunit 7 0.0243 0.0515 0.1757
Entamoeba histolytica acyl-coA synthetase, putative 0.0094 0.0155 0.0479
Schistosoma mansoni leucyl-tRNA synthetase 0.0086 0.0137 0.0244
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0243 0.0515 0.1773
Echinococcus multilocularis regulator of G protein signaling 7 0.0058 0.0069 0.0069
Schistosoma mansoni coup transcription factor 0.0051 0.0052 0.0093
Plasmodium vivax endoplasmic reticulum oxidoreductin, putative 0.0056 0.0066 0.0208
Brugia malayi proteasome subunit alpha type 1 0.0243 0.0515 0.0624
Mycobacterium tuberculosis Conserved protein 0.0077 0.0115 0.0396
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0573 0.1306 0.4497
Trypanosoma brucei protein kinase, putative 0.0051 0.0053 0.0182
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0052 0.0093
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0371 0.0821 0.1642
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.049 0.049
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Echinococcus granulosus Smad4 0.0234 0.0493 0.0987
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0052 0.0203
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0371 0.0821 0.2825
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0234 0.0807
Echinococcus multilocularis lamin dm0 0.0033 0.0009 0.0009
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0963 0.2241 0.7716
Loa Loa (eye worm) hypothetical protein 0.0094 0.0155 0.0188
Treponema pallidum methionyl-tRNA synthetase 0.0086 0.0137 0.0355
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0096 0.017
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.008 0.0123 0.0304
Brugia malayi ecdysteroid receptor 0.0051 0.0052 0.0063
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0243 0.0515 0.0916
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0371 0.0821 0.2825
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0963 0.2241 0.3986
Brugia malayi beta-lactamase family protein 0.0077 0.0115 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0052 0.0093
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0183 0.0369 0.1271
Loa Loa (eye worm) hypothetical protein 0.0058 0.0069 0.0083
Brugia malayi intermediate filament protein 0.0033 0.0009 0.001
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0183 0.0369 0.1271
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0035 0.0035
Echinococcus multilocularis thioredoxin glutathione reductase 0.0253 0.0537 0.0537
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Brugia malayi hypothetical protein 0.0223 0.0465 0.0563
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0243 0.0515 0.9626
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0087 0.0139 0.048
Mycobacterium ulcerans beta-lactamase 0.0077 0.0115 0.0396
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.036 0.113
Toxoplasma gondii NADPH-glutathione reductase 0.0087 0.0139 0.048
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.0409 0.0409
Echinococcus multilocularis peregrin 0.0031 0.0005 0.0005
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0279 0.0601 0.2069
Brugia malayi Proteasome subunit alpha type 7-1 0.0243 0.0515 0.0624
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0243 0.0515 0.1773
Echinococcus multilocularis Smad4 0.0234 0.0493 0.0493
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0378 0.0837 0.1488
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0017 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0052 0.0063
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0052 0.0104
Schistosoma mansoni methionine-tRNA synthetase 0.0086 0.0137 0.0244
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Onchocerca volvulus 0.0992 0.2311 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.0155 0.0479
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0243 0.0515 0.1671
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0226 0.0472 0.1625
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0155 0.0535
Echinococcus multilocularis proteasome subunit beta type 6 0.0243 0.0515 0.0515
Echinococcus multilocularis regulator of G protein signaling 7 0.0058 0.0069 0.0069
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0087 0.0139 0.0169
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0243 0.0515 0.1773
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0052 0.0063
Schistosoma mansoni hypothetical protein 0.1236 0.2898 0.5155
Leishmania major endoplasmic reticulum oxidoreductin, putative 0.0056 0.0066 0.0226
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0052 0.0092
Loa Loa (eye worm) TAR-binding protein 0.0902 0.2096 0.2539
Schistosoma mansoni tar DNA-binding protein 0.0902 0.2096 0.3729
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0573 0.1306 0.4497
Echinococcus granulosus citrate lyase subunit beta protein 0.0049 0.0047 0.0094
Brugia malayi hypothetical protein 0.0233 0.049 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0123 0.0304
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0234 0.0234
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0087 0.0139 0.048
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0047 0.0162
Brugia malayi Proteasome A-type and B-type family protein 0.1239 0.2904 0.3518
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0033 0.0059
Trypanosoma brucei polo-like protein kinase 0.0279 0.0601 0.2069
Toxoplasma gondii methionyl-tRNA synthetase 0.0226 0.0472 0.1625
Schistosoma mansoni topbp1 0.008 0.0123 0.0218
Loa Loa (eye worm) hypothetical protein 0.0233 0.049 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0052 0.0063
Brugia malayi regulator of G-protein signaling egl-10 0.0058 0.0069 0.0083
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0963 0.2241 0.7688
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0115 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0234 0.0417
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0243 0.0515 0.1724
Schistosoma mansoni alpha-glucosidase 0.0169 0.0337 0.0599
Brugia malayi isocitrate dehydrogenase 0.0371 0.0821 0.0994
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0087 0.0139 0.0139
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0243 0.0515 0.1757
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0234 0.0469
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0052 0.0104
Echinococcus multilocularis mothers against decapentaplegic 5 0.0234 0.0493 0.0493
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0045 0.0054
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0155 0.0535
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 1
Echinococcus multilocularis smad 0.0234 0.0493 0.0493
Echinococcus multilocularis dnaJ subfamily B 0.1236 0.2898 0.2898
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1239 0.2904 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0047 0.0162
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0371 0.0821 0.2812
Schistosoma mansoni hypothetical protein 0.0036 0.0017 0.003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0094 0.0155 0.0535
Loa Loa (eye worm) hypothetical protein 0.0345 0.0758 0.0918
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0165 0.0326 0.1121
Plasmodium falciparum thioredoxin reductase 0.0251 0.0533 0.1822
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0963 0.2241 0.7716
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0243 0.0515 0.1773
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0045 0.0039 0.0069
Brugia malayi proteasome subunit alpha type 2 0.0243 0.0515 0.0624
Leishmania major proteasome beta-1 subunit, putative 0.0243 0.0515 0.1773
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1239 0.2904 1
Schistosoma mansoni alpha glucosidase 0.0044 0.0035 0.0063
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 0.1821
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0234 0.0417
Echinococcus multilocularis protein patched 0.0084 0.0132 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.0345 0.0758 0.261
Toxoplasma gondii thioredoxin reductase 0.0251 0.0533 0.1837
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0596 0.1362 0.468
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0243 0.0515 0.1773
Plasmodium falciparum ataxin-2 like protein, putative 0.0345 0.0758 0.2596
Echinococcus granulosus regulator of G protein signaling 7 0.0058 0.0069 0.0138
Trypanosoma brucei proteasome beta 6 subunit 0.0963 0.2241 0.7716
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0596 0.1362 0.469
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0243 0.0515 0.0916
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0279 0.0601 0.0728
Echinococcus multilocularis mothers against decapentaplegic 6 0.0105 0.0182 0.0182
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0045 0.0039 0.0133
Brugia malayi Endoplasmic Reticulum Oxidoreductin 1 0.0056 0.0066 0.0079
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0403 0.0488
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Brugia malayi Proteasome subunit alpha type 1 0.0243 0.0515 0.0624
Onchocerca volvulus 0.0087 0.0139 0.0578
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0178 0.0358 0.1217
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0115 0.0396
Trypanosoma cruzi GMP reductase 0.0183 0.0369 0.1271
Schistosoma mansoni tar DNA-binding protein 0.0902 0.2096 0.3729
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0243 0.0515 0.1757
Schistosoma mansoni hypothetical protein 0.0081 0.0125 0.0222
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0052 0.0104
Echinococcus granulosus TGF beta signal transducer SmadC 0.0234 0.0493 0.0987
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0243 0.0515 0.1773
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0573 0.1306 0.4497
Brugia malayi proteasome subunit beta type 1 0.0963 0.2241 0.2714
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0243 0.0515 0.1757
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0155 0.0535
Plasmodium vivax SET domain protein, putative 0.0127 0.0234 0.079
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0243 0.0515 0.1773
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0049 0.0047 0.0162
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0403 0.0488
Brugia malayi hypothetical protein 0.008 0.0123 0.0148
Echinococcus granulosus proteasome subunit beta type 6 0.0243 0.0515 0.103
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0902 0.2096 0.2539
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0053 0.0053
Loa Loa (eye worm) Smad1 0.0234 0.0493 0.0598
Toxoplasma gondii histone lysine methyltransferase SET1 0.0169 0.0336 0.1157
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0243 0.0515 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0052 0.0063
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0243 0.0515 0.0624
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0126 0.0223
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0052 0.0052
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.008 0.0123 0.0422
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0043 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0902 0.2096 0.3729
Brugia malayi serine/threonine-protein kinase plk-2 0.0279 0.0601 0.0728
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0045 0.0039 0.0047
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0243 0.0515 0.1724
Echinococcus granulosus regulator of G protein signaling 7 0.0058 0.0069 0.0138
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0243 0.0515 0.1773
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0243 0.0515 0.1773
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1239 0.2904 0.3518
Schistosoma mansoni cpg binding protein 0.0092 0.0151 0.0268
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0132 0.0264
Loa Loa (eye worm) proteasome subunit beta type 3 0.0243 0.0515 0.0624
Loa Loa (eye worm) DIX domain-containing protein 0.0039 0.0024 0.0028
Schistosoma mansoni hypothetical protein 0.1097 0.2565 0.4562
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0039 0.0024 0.0028
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0035 0.0121
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0243 0.0515 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0123 0.0304
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0017 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.0345 0.0758 0.2596
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0052 0.0093
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0243 0.0515 0.1773
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0243 0.0515 0.1773
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0183 0.0369 0.0739
Toxoplasma gondii ATPase, AAA family protein 0.008 0.0123 0.0422
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0087 0.0139 0.048
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0069 0.0137
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0058 0.0069 0.0083
Brugia malayi jmjC domain containing protein 0.0102 0.0176 0.0213
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.01 0.0169 0.0583
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0098 0.0339
Echinococcus granulosus Proteasome subunit alpha beta 0.0243 0.0515 0.103
Giardia lamblia NADH oxidase lateral transfer candidate 0.0087 0.0139 0.0462
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1239 0.2904 1
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0052 0.0093
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0234 0.0417
Plasmodium falciparum thioredoxin reductase 0.0087 0.0139 0.0462
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0371 0.0821 0.0821
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0096 0.0329
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0243 0.0515 0.103
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0199 0.0407 0.0725
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0086 0.0137 0.0274
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0064 0.0084 0.0102
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0243 0.0515 0.0916
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0371 0.0821 0.2812
Schistosoma mansoni cpg binding protein 0.0087 0.0139 0.0247
Leishmania major cytochrome p450-like protein 0.0047 0.0043 0.0148
Plasmodium falciparum proteasome subunit beta type-5 0.1239 0.2904 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0053 0.0061
Brugia malayi MH2 domain containing protein 0.3442 0.8191 0.9922
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0053 0.0182
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0094 0.0155 0.0188
Schistosoma mansoni smad1 5 8 and 0.0234 0.0493 0.0877
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0087 0.0138 0.0476
Echinococcus multilocularis Endoplasmic reticulum oxidoreductin 1 0.0056 0.0066 0.0066
Leishmania major hypothetical protein, conserved 0.0422 0.0943 0.3246
Trichomonas vaginalis glutathione reductase, putative 0.0087 0.0139 0.0363
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0087 0.0139 0.0462
Echinococcus granulosus smad 0.0234 0.0493 0.0987
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0047 0.0162
Brugia malayi MH1 domain containing protein 0.0234 0.0493 0.0598
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0243 0.0515 0.1773
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0047 0.0162
Loa Loa (eye worm) hypothetical protein 0.0086 0.0137 0.0166
Loa Loa (eye worm) proteasome subunit beta type 2 0.0596 0.1362 0.165
Brugia malayi Cytochrome P450 family protein 0.0107 0.0187 0.0227
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 0.1836
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0119
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0052 0.0093
Echinococcus multilocularis cpg binding protein 0.0092 0.0151 0.0151
Toxoplasma gondii IMP dehydrogenas 0.0183 0.0369 0.1271
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.008 0.0123 0.0304
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0094 0.0155 0.0188
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 0.1836
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0045 0.0039 0.0039
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0243 0.0515 0.1773
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.008 0.0123 0.0366
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0033 0.004
Toxoplasma gondii ABC1 family protein 0.0077 0.0115 0.0396
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0052 0.0203
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.1097 0.2565 0.5132
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0251 0.0533 0.1836
Echinococcus granulosus cpg binding protein 0.0092 0.0151 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0052 0.0063
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0139 0.0265 0.0321
Brugia malayi proteasome subunit alpha type 3 0.0243 0.0515 0.0624
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0243 0.0515 0.1757
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0243 0.0515 0.1757
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0243 0.0515 0.1773
Leishmania major proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Leishmania major proteasome alpha 3 subunit, putative 0.0243 0.0515 0.1773
Mycobacterium tuberculosis Conserved protein 0.0077 0.0115 0.0396
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0052 0.0092
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.008 0.0123 0.0422
Schistosoma mansoni hypothetical protein 0.0155 0.0302 0.0537
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0115 0.0396
Loa Loa (eye worm) GMP reductase 0.0079 0.0119 0.0145
Giardia lamblia 20S proteasome alpha subunit 2 0.0243 0.0515 0.1757
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Toxoplasma gondii isocitrate dehydrogenase 0.0371 0.0821 0.2825
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0048 0.0085
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0006 0.0012
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0243 0.0515 0.0515
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.0409 0.0818
Echinococcus multilocularis isocitrate dehydrogenase 0.0371 0.0821 0.0821
Echinococcus granulosus replication factor c subunit 1 0.008 0.0123 0.0245
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0017 0.0017
Onchocerca volvulus 0.0077 0.0115 0.0476
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0596 0.1362 0.4625
Onchocerca volvulus 0.0051 0.0052 0.0201
Brugia malayi hypothetical protein 0.0345 0.0758 0.0918
Schistosoma mansoni hypothetical protein 0.0307 0.0668 0.1189
Brugia malayi Probable isocitrate dehydrogenase 0.0045 0.0039 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0053 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0155 0.0535
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0963 0.2241 0.7716
Brugia malayi MAP kinase sur-1 0.0051 0.0053 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Brugia malayi mothers against decapentaplegic homolog 3 0.0105 0.0182 0.022
Echinococcus granulosus nibrin 0.008 0.0123 0.0245
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0087 0.0139 0.048
Giardia lamblia Kinase, PLK 0.0279 0.0601 0.2054
Loa Loa (eye worm) hypothetical protein 0.0196 0.04 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0052 0.0063
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0243 0.0515 0.1757
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0052 0.0063
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0243 0.0515 0.1773
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0089 0.0307
Brugia malayi methionyl-tRNA synthetase 0.0226 0.0472 0.0572
Plasmodium vivax methionine--tRNA ligase, putative 0.0086 0.0137 0.0454
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0053 0.0182
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0043 0.0052
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0243 0.0515 0.1773
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0079 0.0119 0.0145
Onchocerca volvulus 0.0094 0.0155 0.065
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0115 0.0205
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0087 0.0139 0.0942
Onchocerca volvulus 0.0127 0.0234 0.0993
Onchocerca volvulus 0.0039 0.0024 0.0078
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0115 0.0139
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0155 0.0535
Brugia malayi Bromodomain containing protein 0.0031 0.0005 0.0007
Echinococcus granulosus intermediate filament protein 0.0033 0.0009 0.0017
Brugia malayi hypothetical protein 0.0039 0.0024 0.0028
Trypanosoma cruzi GMP reductase 0.0183 0.0369 0.1271
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0234 0.0417
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0052 0.0052
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0243 0.0515 0.1724
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0243 0.0515 0.0624
Onchocerca volvulus 0.0139 0.0265 0.1127

Activities

Activity type Activity value Assay description Source Reference
Inhibition (ADMET) = 101.9281723 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 118.1211282 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Potency (functional) 16.3555 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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