Detailed information for compound 570622

Basic information

Technical information
  • TDR Targets ID: 570622
  • Name: sodium (6R,7S)-7-[[2-(cyanomethylsulfanyl)ace tyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-y l)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4 .2.0]oct-2-ene-2-carboxylate
  • MW: 493.516 | Formula: C15H16N7NaO5S3
  • H donors: 1 H acceptors: 8 LogP: -0.15 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCSCC(=O)N[C@]1(OC)C(=O)N2[C@@H]1SCC(=C2C(=O)[O-])CSc1nnnn1C.[Na+]
  • InChi: 1S/C15H17N7O5S3.Na/c1-21-14(18-19-20-21)30-6-8-5-29-13-15(27-2,17-9(23)7-28-4-3-16)12(26)22(13)10(8)11(24)25;/h13H,4-7H2,1-2H3,(H,17,23)(H,24,25);/q;+1/p-1/t13-,15+;/m1./s1
  • InChiKey: BITQGIOJQWZUPL-PBCQUBLHSA-M  


Substructure search Similarity search

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Synonyms

  • sodium (6R,7S)-7-[[2-(cyanomethylthio)-1-oxoethyl]amino]-7-methoxy-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • sodium (6R,7S)-7-[2-(cyanomethylsulfanyl)ethanoylamino]-7-methoxy-3-[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • sodium (6R,7S)-7-[[2-(cyanomethylthio)acetyl]amino]-8-keto-7-methoxy-3-[[(1-methyltetrazol-5-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • Cefmetazole
  • 56796-39-5
  • EU-0100266
  • C6048_SIGMA
  • CMZ
  • Cefmetazole sodium (JP15/USP)
  • D00911
  • Zefazone (TN)
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((((cyanomethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodium salt, (6R-cis)-
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((((cyanomethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, sodium salt, (6R-cis)-
  • CMZ sodium
  • CS 1170 sodium
  • Cefmetazole sodium [USAN:JAN]
  • Cefmetazon
  • SKF 83088 sodium
  • Sodium (6R,7S)-7-(2-((cyanomethyl)thio)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
  • U 72791A
  • Zefazone
  • CEFMETAZOLE SODIUM SALT
  • MLS000028660
  • SMR000058923
  • Prestwick_21
  • C08104
  • Cefmetazole sodium

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Escherichia coli endonuclease IV with intrinsic 3'-5' exonuclease activity Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum AP endonuclease of the TIM barrel fold, possible bacterial horizontal transfer Get druggable targets OG5_129467 All targets in OG5_129467
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase Get druggable targets OG5_129467 All targets in OG5_129467
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_129467 All targets in OG5_129467
Cryptosporidium hominis apurinic/apyrimidinic endonuclease Apn1 Get druggable targets OG5_129467 All targets in OG5_129467
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129467 All targets in OG5_129467
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis apurinic endonuclease (APN1) family protein Get druggable targets OG5_129467 All targets in OG5_129467
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii AP endonuclease 1 Get druggable targets OG5_129467 All targets in OG5_129467
Neospora caninum endonuclease V, putative Get druggable targets OG5_129467 All targets in OG5_129467
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans apurinic/apyrimidinic endonuclease/3'-repair diesterase Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii endonuclease IV APN Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0004 0.0011
Trypanosoma brucei fatty acyl CoA synthetase 3 0.0012 0.0004 0.0092
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0221 0.0173 0.0788
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0032 0.0123
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.007 0.2105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.001 0.0559
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0012 0.0004 0.0041
Onchocerca volvulus 0.0522 0.0417 0.703
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0012 0.0004 0.0061
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.016 0.4925
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0296 0.0234 0.093
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.001 0.0002 0.0002
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0012
Schistosoma mansoni hypothetical protein 0.0069 0.0049 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0016 0.0435
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.001 0.0339
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.004 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Echinococcus multilocularis lamin dm0 0.003 0.0018 0.0018
Plasmodium falciparum glutathione reductase 0.0057 0.004 0.1184
Toxoplasma gondii type I fatty acid synthase, putative 0.0012 0.0004 0.005
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.001 0.0559
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0048
Toxoplasma gondii hypothetical protein 0.0012 0.0004 0.005
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0064 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.001 0.0048
Entamoeba histolytica cysteine protease, putative 0.001 0.0002 0.0051
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0017 0.0946
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0066 0.0066
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0024 0.0598
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0002 0.0002
Entamoeba histolytica papain family cysteine protease domain containing protein 0.001 0.0002 0.0051
Plasmodium vivax vivapain-3 0.0028 0.0017 0.0456
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.001 0.0002 0.0034
Leishmania major acetyl-CoA synthetase, putative 0.0087 0.0064 0.2686
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.001 0.0002 0.0034
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0012 0.0004 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Brugia malayi AMP-binding enzyme family protein 0.0087 0.0064 0.0292
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.003 0.003
Mycobacterium tuberculosis Probable reductase 0.013 0.0099 0.0394
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0042 0.1234
Echinococcus granulosus flap endonuclease 1 0.0026 0.0015 0.0015
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0087 0.0064 0.3573
Brugia malayi glutathione reductase 0.0057 0.004 0.0183
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.016 0.9095
Schistosoma mansoni coup transcription factor 0.0021 0.001 0.001
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0118 0.0118
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.001 0.0002 0.0113
Echinococcus granulosus expressed protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0107
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.004 0.2275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 0.0012 0.0004 0.0011
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0099 0.0394
Entamoeba histolytica hypothetical protein 0.0012 0.0004 0.0091
Loa Loa (eye worm) patched family protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0007 0.0031
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0007 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0064 0.0253
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0016 0.0804
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.001 0.0244
Leishmania major DNA polymerase kappa, putative 0.0014 0.0006 0.0153
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0012
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.001 0.0296
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.001 0.001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0111 0.0441
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0064 0.0253
Echinococcus granulosus cathepsin l cysteine peptidase 0.0055 0.0038 0.0038
Schistosoma mansoni cathepsin B (C01 family) 0.001 0.0002 0.0002
Schistosoma mansoni DNA polymerase eta 0.0077 0.0057 0.0057
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0006 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0296 0.0234 1
Onchocerca volvulus 0.0094 0.007 0.1176
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0296 0.0234 0.093
Schistosoma mansoni smad1 5 8 and 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0026 0.012
Mycobacterium tuberculosis Conserved protein 0.0225 0.0176 0.07
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Loa Loa (eye worm) hypothetical protein 0.0204 0.0159 0.0726
Loa Loa (eye worm) glutaminase 2 0.033 0.0261 0.1191
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0016
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Echinococcus granulosus FTZ F1 alpha 0.0021 0.001 0.001
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 0.0012 0.0004 0.0004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0225 0.0176 0.0802
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0493 0.0393 1
Mycobacterium ulcerans esterase/lipase LipP 0.0225 0.0176 0.07
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.001 0.0559
Leishmania major cathepsin L-like protease 0.0055 0.0038 0.1562
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0407 0.0324 0.1289
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0087 0.0064 0.0253
Schistosoma mansoni smad 0.001 0.0002 0.0002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0009 0.021
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0012
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0002 0.0011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0009 0.0204
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.008
Giardia lamblia DNA damage repair protein 0.0014 0.0006 0.009
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0002 0.0008
Toxoplasma gondii cathepsin CPL 0.0055 0.0038 0.1125
Entamoeba histolytica cysteine proteinase 2 0.0028 0.0017 0.0424
Onchocerca volvulus 0.0012 0.0004 0.0065
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0006 0.0314
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0055 0.3119
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0002 0.0008
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.0065 0.0065
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0009 0.0032
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0032 0.0144
Loa Loa (eye worm) hypothetical protein 0.0225 0.0176 0.0802
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0099 0.0394
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0048
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0407 0.0324 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0407 0.0324 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0055 0.0038 0.0174
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0009 0.0496
Brugia malayi Patched protein homolog 1 0.0012 0.0004 0.0017
Loa Loa (eye worm) beta-lactamase 0.0225 0.0176 0.0802
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.003 0.0506
Leishmania major cathepsin L-like protease 0.0055 0.0038 0.1562
Entamoeba histolytica hypothetical protein 0.001 0.0002 0.0051
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0004
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0015 0.0068
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 0.0012 0.0004 0.0011
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.001 0.0047
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.0118 0.0118
Onchocerca volvulus 0.0554 0.0443 0.7475
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.001 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0111 0.0504
Mycobacterium tuberculosis Probable esterase LipL 0.0225 0.0176 0.07
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.001 0.0048
Loa Loa (eye worm) fibroinase 0.0055 0.0038 0.0174
Schistosoma mansoni ferritin 0.0009 0.0001 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0006 0.0203
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0015 0.0252
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0012 0.0004 0.0204
Toxoplasma gondii propionate-CoA ligase 0.0087 0.0064 0.1935
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Mycobacterium tuberculosis Conserved protein 0.0225 0.0176 0.07
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.001 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.001 0.0002 0.0009
Brugia malayi CXXC zinc finger family protein 0.0028 0.0017 0.0076
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0057 0.3131
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0032 0.1699
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0225 0.0176 0.0802
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.001 0.0258
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0012 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0011
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Onchocerca volvulus Cathepsin L homolog 0.001 0.0002 0.0034
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0012 0.0004 0.0041
Toxoplasma gondii hypothetical protein 0.0012 0.0004 0.0057
Echinococcus granulosus cathepsin b 0.001 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0017 0.0946
Mycobacterium tuberculosis Probable lipase LipD 0.0225 0.0176 0.07
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.003 0.0869
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0006 0.0314
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0006 0.0025
Brugia malayi Bromodomain containing protein 0.0038 0.0024 0.0111
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0004 0.0011
Plasmodium falciparum DNA repair protein REV1, putative 0.0014 0.0006 0.011
Echinococcus granulosus Niemann Pick C1 protein 0.0204 0.0159 0.0159
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0087 0.0064 0.0064
Trichomonas vaginalis antibiotic synthetase, putative 0.0087 0.0064 0.1084
Brugia malayi cathepsin Z-like cysteine proteinase 0.001 0.0002 0.0009
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0002 0.0008
Brugia malayi hypothetical protein 0.0011 0.0003 0.0012
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0002 0.0011
Trichomonas vaginalis glutathione reductase, putative 0.002 0.001 0.0166
Giardia lamblia DINP protein human, muc B family 0.0047 0.0032 0.0756
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0002 0.0002
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0002 0.0002
Entamoeba histolytica papain family cysteine protease domain containing protein 0.001 0.0002 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.001 0.0584
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0087 0.0064 0.0064
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.3099 0.2506 1
Schistosoma mansoni hypothetical protein 0.0032 0.002 0.002
Echinococcus granulosus acyl coenzyme A synthetase family 0.0012 0.0004 0.0004
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0002 0.0042
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0004 0.0011
Entamoeba histolytica cysteine protease, putative 0.0055 0.0038 0.0971
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.001 0.0048
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0038 0.0971
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.005 0.2071
Leishmania major hypothetical protein, conserved 0.0012 0.0004 0.0069
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0004 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Schistosoma mansoni hypothetical protein 0.0084 0.0062 0.0062
Brugia malayi hypothetical protein 0.2716 0.2195 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Plasmodium falciparum thioredoxin reductase 0.0057 0.004 0.1184
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0407 0.0324 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.002 0.002
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.001 0.0048
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0407 0.0324 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0004 0.0011
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.001 0.0047
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.016 0.4945
Echinococcus granulosus tumor protein p63 0.3563 0.2882 0.2882
Echinococcus multilocularis neuropeptide receptor A26 0.0516 0.0412 0.0412
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0002 0.0008
Echinococcus multilocularis Niemann Pick C1 protein 0.0204 0.0159 0.0159
Onchocerca volvulus 0.0092 0.0068 0.1148
Schistosoma mansoni apoferritin-2 0.0009 0.0001 0.0001
Trypanosoma cruzi fatty acyl CoA synthetase, putative 0.0012 0.0004 0.0204
Echinococcus granulosus long chain fatty acid coenzyme A ligase 4 0.0012 0.0004 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0071 0.0071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.049 0.0391 0.0391
Trypanosoma brucei unspecified product 0.0032 0.002 0.1026
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.005 0.0196
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.016 0.0637
Trichomonas vaginalis antibiotic synthetase, putative 0.0087 0.0064 0.1084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.001 0.0048
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0064 0.0253
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0011
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.001 0.0451
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0038 0.0971
Brugia malayi hypothetical protein 0.001 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0006 0.0203
Leishmania major trypanothione reductase 0.0057 0.004 0.1645
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0026 0.0102
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0004 0.0011
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0015 0.0248
Loa Loa (eye worm) hypothetical protein 0.0221 0.0173 0.0788
Brugia malayi hypothetical protein 0.002 0.001 0.0047
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0407 0.0324 1
Brugia malayi cathepsin L precursor 0.001 0.0002 0.0009
Toxoplasma gondii patched family protein 0.0012 0.0004 0.0057
Mycobacterium ulcerans acyl-CoA synthetase 0.0296 0.0234 0.093
Echinococcus granulosus Protein patched homolog 1 0.0088 0.0065 0.0065
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.001 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.001 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0064 0.0253
Plasmodium vivax long-chain fatty acid CoA ligase, putative 0.0012 0.0004 0.005
Echinococcus granulosus Smad4 0.001 0.0002 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.049 0.0391 0.0391
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0163 0.9246
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.002 0.002
Echinococcus granulosus bloom syndrome protein 0.0026 0.0015 0.0015
Schistosoma mansoni cathepsin s 0.0018 0.0008 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.002 0.002
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0015 0.0403
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0002 0.0002
Leishmania major long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative 0.0012 0.0004 0.0069
Echinococcus multilocularis expressed conserved protein 0.0192 0.0149 0.0149
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0032 0.0032
Plasmodium falciparum glutathione reductase 0.002 0.001 0.0244
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0032 0.0533
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0048
Mycobacterium ulcerans TetR family transcriptional regulator 0.3099 0.2506 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0004 0.005
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0032 0.0123
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0016
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0087 0.0064 0.0253
Brugia malayi polk-prov protein 0.0014 0.0006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0025
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0004
Mycobacterium leprae POSSIBLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE) 0.0012 0.0004 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.001 0.0559
Loa Loa (eye worm) patched family protein 0.0012 0.0004 0.0017
Echinococcus multilocularis cysteine protease 0.0055 0.0038 0.0038
Plasmodium vivax SET domain protein, putative 0.0094 0.007 0.2105
Plasmodium vivax vivapain-2 0.0055 0.0038 0.1125
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.001 0.0282
Onchocerca volvulus 0.0055 0.0038 0.0644
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0087 0.0064 0.0253
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0006 0.0203
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0002 0.0009
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0087 0.0064 0.0253
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0002 0.0009
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.0006 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0002 0.0034
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0054 0.0214
Echinococcus granulosus AMP dependent ligase 0.0012 0.0004 0.0004
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0012 0.0004 0.0204
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0002 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.001 0.0002 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Mycobacterium ulcerans acyl-CoA synthetase 0.0296 0.0234 0.093
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.016 0.9095
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.0038 0.0038
Leishmania major cysteine peptidase A (CPA) 0.0055 0.0038 0.1562
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0032 0.1699
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.001 0.001
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.016 0.016
Echinococcus granulosus muscleblind protein 0.0157 0.0121 0.0121
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0111 0.0441
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0087 0.0064 0.3645
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0296 0.0234 0.1064
Loa Loa (eye worm) hypothetical protein 0.0218 0.0171 0.0777
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0087 0.0064 0.0253
Trypanosoma cruzi fatty acyl CoA synthetase, putative 0.0012 0.0004 0.0204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0038 0.0644
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.001 0.0584
Trypanosoma cruzi AMP-binding enzyme, putative 0.0012 0.0004 0.0204
Echinococcus multilocularis AMP dependent ligase 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0225 0.0176 0.0802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0407 0.0324 0.1289
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0004 0.0016
Echinococcus multilocularis expressed protein 0.0009 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0032 0.002 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.001 0.001
Echinococcus multilocularis replication factor c subunit 1 0.002 0.001 0.001
Toxoplasma gondii patched family protein 0.0012 0.0004 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Echinococcus multilocularis geminin 0.0187 0.0146 0.0146
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0032 0.1699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Echinococcus granulosus ferritin 0.0009 0.0001 0.0001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.001 0.0036
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0012 0.0004 0.0011
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0225 0.0176 0.2973
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0009 0.004
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.001 0.0002 0.0002
Echinococcus multilocularis cysteine protease 0.0055 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.001 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0493 0.0393 0.6639
Brugia malayi AMP-binding enzyme family protein 0.0296 0.0234 0.1064
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0002 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0087 0.0064 0.0292
Leishmania major cathepsin L-like protease 0.0055 0.0038 0.1562
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.001 0.0038
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 0.0012 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0064 0.0253
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0017 0.0946
Echinococcus multilocularis Niemann Pick C1 protein 0.0292 0.023 0.023
Brugia malayi Disco-interacting protein 2 homolog 0.0012 0.0004 0.0016
Brugia malayi nuclear receptor NHR-67 0.001 0.0002 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0038 0.0644
Loa Loa (eye worm) hypothetical protein 0.0157 0.0121 0.0553
Toxoplasma gondii hypothetical protein 0.014 0.0107 0.3278
Trichomonas vaginalis D-aminoacylase, putative 0.0225 0.0176 0.2973
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.001 0.001
Schistosoma mansoni ferritin light chain 0.0009 0.0001 0.0001
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0102 0.0102
Echinococcus granulosus beta LACTamase domain containing family member 0.0225 0.0176 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.001 0.0048
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0004 0.0004
Brugia malayi Bromodomain containing protein 0.0075 0.0055 0.025
Loa Loa (eye worm) patched family protein 0.0012 0.0004 0.0017
Schistosoma mansoni hypothetical protein 0.049 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0107
Onchocerca volvulus 0.0225 0.0176 0.2973
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.016 0.4798
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0002 0.0011
Brugia malayi ecdysone receptor 0.001 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Brugia malayi beta-lactamase family protein 0.0225 0.0176 0.0802
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0047
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0008 0.0039
Schistosoma mansoni hypothetical protein 0.0084 0.0062 0.0062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.001 0.0559
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.005 0.0228
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0002 0.0002
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0087 0.0064 0.1935
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0011
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.001 0.0244
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.001 0.001
Toxoplasma gondii patched family protein 0.0012 0.0004 0.0057
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0407 0.0324 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.0176 0.0802
Schistosoma mansoni peptidase Clp (S14 family) 0.0407 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0221 0.0173 0.0788
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0032 0.1793
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0009 0.0291
Brugia malayi hypothetical protein 0.0012 0.0004 0.0017
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0012 0.0004 0.0011
Schistosoma mansoni cpg binding protein 0.0028 0.0017 0.0017
Schistosoma mansoni AMP dependent ligase 0.0012 0.0004 0.0004
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0009 0.0388
Loa Loa (eye worm) hypothetical protein 0.2716 0.2195 1
Schistosoma mansoni DNA helicase recq1 0.0011 0.0002 0.0002
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0002 0.0011
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.001 0.0244
Trypanosoma brucei fatty acyl CoA synthetase 4 0.0012 0.0004 0.0092
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0032 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.001 0.0002 0.0034
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0012 0.0004 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0004 0.0011
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0012 0.0004 0.0011
Onchocerca volvulus 0.001 0.0002 0.0028
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0015 0.0849
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0023
Loa Loa (eye worm) glutathione reductase 0.0057 0.004 0.0183
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0296 0.0234 0.093
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0107
Trichomonas vaginalis AMP dependent ligase, putative 0.0012 0.0004 0.0061
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0187 0.0146 0.0146
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0017 0.0017
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0055 0.3119
Brugia malayi steroid hormone receptor 0.0021 0.001 0.0048
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.001 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0024 0.0397
Schistosoma mansoni nuclear hormone receptor 0.0021 0.001 0.001
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0087 0.0064 0.0253
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0225 0.0176 0.07
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.001 0.001
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0015 0.0331
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.001 0.001
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0002 0.0002
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0012 0.0004 0.0061
Brugia malayi MH1 domain containing protein 0.001 0.0002 0.0008
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0003 0.0012
Plasmodium vivax vivapain-1 0.0028 0.0017 0.0456
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Echinococcus granulosus geminin 0.0187 0.0146 0.0146
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0039
Brugia malayi nuclear receptor RXR 0.0011 0.0003 0.0012
Onchocerca volvulus 0.0225 0.0176 0.2973
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.003 0.17
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0002 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0069 0.2078
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0012 0.0004 0.0204
Mycobacterium ulcerans lipase LipD 0.0225 0.0176 0.07
Onchocerca volvulus 0.0012 0.0004 0.0061
Loa Loa (eye worm) patched family protein 0.0012 0.0004 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0296 0.0234 0.1064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0225 0.0176 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0002 0.0002
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0087 0.0064 0.0253
Leishmania major 4-coumarate:coa ligase-like protein 0.0296 0.0234 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0493 0.0393 0.6639
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0296 0.0234 1
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0012 0.0004 0.0061
Echinococcus multilocularis Smad4 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.0069 0.0272
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.001 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.001 0.0002 0.0034
Echinococcus granulosus survival motor neuron protein 1 0.2716 0.2195 0.2195
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.005 0.0196
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0296 0.0234 0.093
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0004
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0002 0.0002
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0002 0.0002
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0012 0.0004 0.0204
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.016 0.0637
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0225 0.0176 0.0802
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0013 0.0013
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0002 0.0013
Brugia malayi cathepsin L-like cysteine proteinase 0.001 0.0002 0.0009
Onchocerca volvulus 0.003 0.0018 0.0304
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0012 0.0004 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0038 0.0644
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 0.0012 0.0004 0.0004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.003 0.0506
Loa Loa (eye worm) hypothetical protein 0.0044 0.0029 0.0133
Leishmania major hypothetical protein, conserved 0.0015 0.0006 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.001 0.001
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0002 0.0011
Entamoeba histolytica hypothetical protein 0.049 0.0391 0.995
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.001 0.0262
Onchocerca volvulus 0.0012 0.0004 0.0065
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0055 0.3119
Schistosoma mansoni topbp1 0.002 0.001 0.001
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0014 0.0062
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 0.0012 0.0004 0.0004
Brugia malayi DKFZp564C0469 protein 0.002 0.001 0.0047
Schistosoma mansoni hypothetical protein 0.0401 0.0319 0.0319
Onchocerca volvulus 0.0012 0.0004 0.0065
Schistosoma mansoni cellular tumor antigen P53 0.0522 0.0417 0.0417
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0002 0.0002
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 0.0012 0.0004 0.0004
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0002
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.016 0.4925
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.001 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0008 0.0481
Schistosoma mansoni cathepsin S (C01 family) 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.082 0.0658 0.2624
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0002 0.0002
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.004 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0032 0.1699
Brugia malayi cathepsin F-like cysteine proteinase 0.001 0.0002 0.0009
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0007 0.0199
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0002 0.0008
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0087 0.0064 0.0292
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0002 0.0002
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0002 0.0013
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0087 0.0064 0.1935
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.001 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0407 0.0324 0.1474
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0649 0.052 0.2368
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0005 0.017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0071 0.0071
Schistosoma mansoni dishevelled 0.0011 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0037 0.0024 0.0107
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0017 0.0424
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0407 0.0324 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0296 0.0234 0.093
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0407 0.0324 0.1289
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0064 0.0253
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0225 0.0176 0.07
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0004 0.005
Loa Loa (eye worm) intermediate filament protein 0.003 0.0018 0.0082
Treponema pallidum fructose-bisphosphate aldolase 0.0493 0.0393 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0174
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0014 0.0051
Echinococcus granulosus replication factor c subunit 1 0.002 0.001 0.001
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.005 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0017 0.0424
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.001 0.0002 0.0034
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.001 0.0282
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.003 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0009
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.3099 0.2506 1
Leishmania major cathepsin L-like protease 0.0055 0.0038 0.1562
Echinococcus multilocularis tumor protein p63 0.3563 0.2882 0.2882
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0015 0.0015
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0407 0.0324 0.8224
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Echinococcus multilocularis dna polymerase eta 0.0077 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0032 0.002 0.002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0009 0.004
Schistosoma mansoni cpg binding protein 0.0032 0.0019 0.0019
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0004
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0082
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0045 0.0045
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0039
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.003 0.0885
Echinococcus granulosus lamin 0.003 0.0018 0.0018
Entamoeba histolytica cysteine protease, putative 0.001 0.0002 0.0051
Brugia malayi cathepsin Z-like cysteine proteinase 0.001 0.0002 0.0009
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0012 0.0004 0.0061
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0009 0.021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0296 0.0234 0.093
Entamoeba histolytica acyl-CoA synthetase, putative 0.0296 0.0234 0.594
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0004 0.005
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0075 0.0342
Schistosoma mansoni hypothetical protein 0.0084 0.0062 0.0062
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Echinococcus granulosus zinc finger protein 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Leishmania major DNA polymerase eta, putative 0.0077 0.0057 0.2354
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0032 0.1793
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0032 0.1699
Onchocerca volvulus 0.0012 0.0004 0.0065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0071 0.0071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD11 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0004 0.0011
Treponema pallidum NADH oxidase 0.002 0.001 0.0232
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Plasmodium falciparum thioredoxin reductase 0.002 0.001 0.0244
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0039
Onchocerca volvulus 0.0012 0.0004 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0032 0.1793
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0032 0.0123
Brugia malayi nuclear hormone receptor 0.0021 0.001 0.0048
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.001 0.0048
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0012 0.0004 0.0204
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.003 0.17
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.002 0.1026
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0087 0.0064 0.0253
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0024 0.0014 0.0228
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0004 0.005
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0005 0.0281
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Toxoplasma gondii ATPase, AAA family protein 0.002 0.001 0.0258
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0003 0.0003
Mycobacterium ulcerans hypothetical protein 0.0014 0.0006 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0225 0.0176 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0009 0.0496
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0005 0.0023
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.014 0.0107 0.3278
Brugia malayi MH1 domain containing protein 0.001 0.0002 0.0008
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.001 0.0002 0.0113
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0032 0.1699
Brugia malayi Cathepsin L-like precursor 0.0055 0.0038 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0038 0.0644
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.001 0.0476
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0008 0.0036
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.019 0.0148 0.8413
Echinococcus multilocularis survival motor neuron protein 1 0.2716 0.2195 0.2195
Leishmania major DNA polymerase kappa, putative 0.0047 0.0032 0.1277
Brugia malayi cathepsin B-like cysteine proteinase 0.001 0.0002 0.0009
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.005 0.0196
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0002 0.0002
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.001 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0002 0.0034
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0012 0.0004 0.0092
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 0.0012 0.0004 0.0011
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0017 0.0017
Echinococcus multilocularis microtubule associated protein 2 1.2345 1 1
Schistosoma mansoni lamin 0.003 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0011
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0012 0.0004 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0009 0.0009
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.014 0.0107 0.2718
Trichomonas vaginalis D-aminoacylase, putative 0.0225 0.0176 0.2973
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0002 0.0034
Trypanosoma brucei acetyl-CoA synthetase, truncated 0.0012 0.0004 0.0092
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0087 0.0064 0.3645
Trypanosoma brucei acyl-CoA synthetase, putative 0.0012 0.0004 0.0092
Treponema pallidum phosphoglycerate kinase 0.0206 0.016 0.4067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0493 0.0393 0.6639
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0055 0.0038 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0011
Loa Loa (eye worm) glutaminase 0.033 0.0261 0.1191
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0221 0.0173 0.0688
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0174
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0005 0.0084
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0017 0.0017
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.082 0.0658 0.2624
Trichomonas vaginalis ferritin, putative 0.0009 0.0001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0048
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0407 0.0324 0.0324
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0048
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0111 0.0441
Echinococcus granulosus cathepsin b 0.001 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0493 0.0393 0.6639
Echinococcus multilocularis cathepsin b 0.001 0.0002 0.0002
Treponema pallidum long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0073
Echinococcus granulosus dnaJ subfamily B 0.0401 0.0319 0.0319
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0225 0.0176 0.07
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0039
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0002 0.0002
Echinococcus multilocularis muscleblind protein 0.0157 0.0121 0.0121
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.001 0.0174
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0087 0.0064 0.0253
Brugia malayi hypothetical protein 0.0018 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0017 0.0456
Loa Loa (eye worm) hypothetical protein 0.0522 0.0417 0.1897
Echinococcus multilocularis zinc finger protein 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Brugia malayi Patched related family protein 12 0.0012 0.0004 0.0017
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0038 0.0644
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0016
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0004 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0048
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0099 0.0394
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0002 0.0028
Trypanosoma brucei unspecified product 0.0047 0.0032 0.1699
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.0002 0.0034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0075 0.0342
Loa Loa (eye worm) hypothetical protein 0.0157 0.0121 0.0553
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0038 0.0174
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0012 0.0004 0.0041
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0209 0.0163 0.0649
Trypanosoma brucei pantothenate kinase subunit, putative 0.0012 0.0004 0.0092
Brugia malayi Cathepsin L-like precursor 0.0055 0.0038 0.0174
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0017 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0225 0.0176 0.0176
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.003 0.0762
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.0002 0.0034
Echinococcus granulosus expressed conserved protein 0.0192 0.0149 0.0149
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0004 0.0016
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0012 0.0004 0.0061
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0088 0.0065 0.0295
Mycobacterium tuberculosis Probable lipase LipE 0.0225 0.0176 0.07
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0024 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.0038 0.0644
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0012 0.0004 0.0204
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0087 0.0064 0.0253
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0018 0.0082
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0055 0.3041
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.001 0.001
Mycobacterium tuberculosis Putative polyketide synthase Pks16 0.0012 0.0004 0.0011
Schistosoma mansoni microtubule-associated protein tau 1.2345 1 1
Onchocerca volvulus 0.0011 0.0002 0.0042
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0012 0.0004 0.0204
Giardia lamblia Long chain fatty acid CoA ligase 4 0.0012 0.0004 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.001 0.0048
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0017 0.0424
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.005 0.005
Echinococcus multilocularis GPCR, family 2 0.0032 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Mycobacterium tuberculosis Probable hydrolase 0.0225 0.0176 0.07
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0055 0.0038 0.1125
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.001 0.0177
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0008 0.0179
Plasmodium falciparum flap endonuclease 1 0.0026 0.0015 0.0403
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0009 0.0032
Schistosoma mansoni hypothetical protein 0.002 0.001 0.001
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Mycobacterium leprae conserved hypothetical protein 0.0225 0.0176 0.07
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.001 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0087 0.0064 0.0292
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0015 0.0015
Onchocerca volvulus 0.001 0.0002 0.0028
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0008 0.0039
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Plasmodium vivax long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0296 0.0234 0.093
Loa Loa (eye worm) hypothetical protein 0.0077 0.0057 0.0257
Onchocerca volvulus 0.003 0.0018 0.0304
Echinococcus granulosus dna polymerase eta 0.0077 0.0057 0.0057
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0057 0.0257
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0087 0.0064 0.0292
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0009
Trypanosoma cruzi ISWI complex protein 0.0015 0.0006 0.0341
Onchocerca volvulus 0.001 0.0002 0.0034
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0004 0.005
Trypanosoma brucei ISWI complex protein 0.0015 0.0006 0.0231
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0002 0.0002
Trypanosoma cruzi ISWI complex protein 0.0015 0.0006 0.0341
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.016 0.4925
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0121 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0209 0.0163 0.0649
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0016
Brugia malayi Cathepsin L-like precursor 0.0037 0.0024 0.0107
Brugia malayi AMP-binding enzyme family protein 0.0087 0.0064 0.0292
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0024 0.0024
Brugia malayi Phosphoglycerate kinase 0.0075 0.0055 0.025
Trypanosoma brucei hypothetical protein, conserved 0.0225 0.0176 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0009 0.021
Echinococcus granulosus neuropeptide receptor A26 0.0516 0.0412 0.0412
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0002 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Schistosoma mansoni zinc finger protein 0.0021 0.0011 0.0011
Plasmodium vivax acyl-CoA synthetase, putative 0.0221 0.0173 0.5317
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0221 0.0173 0.52
Mycobacterium ulcerans hypothetical protein 0.0024 0.0014 0.0051
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0221 0.0173 0.0688
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0038 0.0038
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0163 0.9246
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0002 0.0002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0111 0.0441
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0087 0.0064 0.1935
Leishmania major cathepsin L-like protease 0.0055 0.0038 0.1562
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0055 0.3119
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0046 0.021
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0005 0.0128
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0026 0.0102
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.0069 0.0272
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0004
Brugia malayi fibroinase precursor 0.001 0.0002 0.0009
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.001 0.001
Onchocerca volvulus 0.0055 0.0038 0.0644
Brugia malayi nuclear receptor NHR-88 0.001 0.0002 0.0008
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.001 0.0174
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 0.0012 0.0004 0.0004
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Schistosoma mansoni inositol monophosphatase 0.0045 0.003 0.003
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Entamoeba histolytica hypothetical protein 0.049 0.0391 0.995
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0002 0.0002
Loa Loa (eye worm) RecQ helicase 0.0026 0.0015 0.0067
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0055 0.3119
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0002
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0004 0.0011
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.0038 0.0644
Loa Loa (eye worm) hypothetical protein 0.0093 0.0069 0.0313
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.007 0.007
Trypanosoma cruzi major cysteine proteinase, putative 0.0164 0.0127 0.7192
Brugia malayi topoisomerase 0.002 0.001 0.0047
Mycobacterium leprae Probable lipase LipE 0.0225 0.0176 0.07
Giardia lamblia Fructose-bisphosphate aldolase 0.0493 0.0393 1
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Entamoeba histolytica acyl-CoA synthetase, putative 0.0012 0.0004 0.0091
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0002 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0016 0.0435
Loa Loa (eye worm) hypothetical protein 0.0107 0.0081 0.0368
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0017 0.0076
Entamoeba histolytica cysteine protease, putative 0.001 0.0002 0.0051
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0055 0.2286
Entamoeba histolytica hypothetical protein 0.049 0.0391 0.995
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.002 0.0089
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.001 0.0584
Echinococcus granulosus cathepsin L 0.0028 0.0017 0.0017
Giardia lamblia Phosphoglycerate kinase 0.0206 0.016 0.4048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.0083 0.0083
Entamoeba histolytica acyl-CoA synthetase, putative 0.0012 0.0004 0.0091
Schistosoma mansoni zinc finger protein 0.0015 0.0006 0.0006
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0099 0.0394
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0015 0.0248
Schistosoma mansoni dishevelled 0.0011 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0174
Loa Loa (eye worm) DR-78 0.001 0.0002 0.0008
Brugia malayi conserved hypotetical protein 0.001 0.0002 0.0008
Brugia malayi MH2 domain containing protein 0.001 0.0002 0.0008
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0038 0.0174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0493 0.0393 0.6639
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0002 0.0002
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0006 0.0203
Mycobacterium ulcerans hypothetical protein 0.0225 0.0176 0.07
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0006 0.0314
Entamoeba histolytica hypothetical protein 0.002 0.001 0.0262
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Leishmania major long chain fatty Acyl CoA synthetase, putative 0.0012 0.0004 0.0069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.011 0.0083 0.0083
Loa Loa (eye worm) papain family cysteine protease containing protein 0.001 0.0002 0.0009
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0006 0.011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.001 0.001
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0012 0.0004 0.0204
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0017 0.0946
Brugia malayi nuclear hormone receptor 0.001 0.0002 0.0008
Mycobacterium ulcerans glutaminase 0.033 0.0261 0.104
Echinococcus granulosus nibrin 0.002 0.001 0.001
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.001 0.0244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0493 0.0393 0.6639
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.001 0.0258
Trypanosoma brucei fatty acyl CoA syntetase 1 0.0012 0.0004 0.0092
Schistosoma mansoni patched 1 0.0088 0.0065 0.0065
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.002 0.1026
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0015 0.038
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0087 0.0064 0.0253
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.014 0.0107 0.0426
Brugia malayi hypothetical protein 0.0012 0.0004 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0065 0.1094
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.001 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.002 0.0089
Brugia malayi Phosphoglycerate kinase 0.0206 0.016 0.0731
Leishmania major DNA damage repair protein, putative 0.0014 0.0006 0.0153
Echinococcus multilocularis peptidase Clp (S14 family) 0.0267 0.021 0.021
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.016 0.4925
Brugia malayi hypothetical protein 0.0011 0.0003 0.0012
Echinococcus granulosus cpg binding protein 0.0032 0.0019 0.0019
Schistosoma mansoni topbp1 0.002 0.001 0.001
Trypanosoma brucei fatty acyl CoA synthetase, putative 0.0012 0.0004 0.0092
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0009 0.0248
Brugia malayi MH2 domain containing protein 0.0144 0.0111 0.0504
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0012 0.0004 0.0069
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Trichomonas vaginalis set domain proteins, putative 0.0739 0.0592 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0203
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0022 0.0022
Brugia malayi Cathepsin L-like precursor 0.0055 0.0038 0.0174
Chlamydia trachomatis DNA ligase 0.002 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0016
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0008 0.0184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.001 0.001
Echinococcus multilocularis protein dispatched 1 0.01 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.001 0.0048
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0004 0.0017
Echinococcus granulosus smad 0.001 0.0002 0.0002
Brugia malayi protein C24B5.3 0.0012 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0048
Chlamydia trachomatis endonuclease IV 0.0093 0.0069 0.188
Brugia malayi Flap endonuclease-1 0.0026 0.0015 0.0068
Brugia malayi Thioredoxin reductase 0.0057 0.004 0.0183
Onchocerca volvulus 0.0055 0.0038 0.0644
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.007 0.005 0.0229
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0055 0.0038 0.1125
Trichomonas vaginalis D-aminoacylase, putative 0.0225 0.0176 0.2973
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0087 0.0064 0.0292
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0014 0.0051
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0012 0.0004 0.0204
Plasmodium vivax vivapain-2 0.0055 0.0038 0.1125
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0087 0.0064 0.3645
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0002 0.0002
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0012 0.0004 0.0061
Onchocerca volvulus Protein patched homolog 0.0012 0.0004 0.0065
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0296 0.0234 0.093
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.016 0.9105
Trichomonas vaginalis AMP dependent ligase, putative 0.0012 0.0004 0.0061
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0015 0.0067
Echinococcus multilocularis nibrin 0.002 0.001 0.001
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.001 0.0036
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0087 0.0064 0.2686
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0012 0.0004 0.0061
Brugia malayi DIX domain containing protein 0.0011 0.0002 0.0011
Onchocerca volvulus 0.0055 0.0038 0.0644
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.001 0.001
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0225 0.0176 0.07
Loa Loa (eye worm) cysteine protease 0.0055 0.0038 0.0174
Schistosoma mansoni ferritin 0.0009 0.0001 0.0001
Schistosoma mansoni intermediate filament proteins 0.003 0.0018 0.0018
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.01 0.0075 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0002 0.0034
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 0.0012 0.0004 0.0004
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0004 0.005
Echinococcus granulosus histone lysine methyltransferase setb 0.011 0.0083 0.0083
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0493 0.0393 1
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0006 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0174
Schistosoma mansoni ferritin 0.0009 0.0001 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0296 0.0234 0.594
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.001 0.0002 0.0034
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.0038 0.0038
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.003 0.1606
Brugia malayi Inositol-1 0.0045 0.003 0.0136
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0296 0.0234 0.1064
Echinococcus multilocularis cathepsin L 0.0028 0.0017 0.0017
Onchocerca volvulus 0.0028 0.0017 0.028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0004 0.0004
Toxoplasma gondii thioredoxin reductase 0.0057 0.004 0.1184
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0032 0.1699
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0225 0.0176 0.2973
Brugia malayi PHD-finger family protein 0.0026 0.0015 0.0068
Toxoplasma gondii hypothetical protein 0.0011 0.0002 0.0016
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0012 0.0004 0.0069
Loa Loa (eye worm) hypothetical protein 0.0024 0.0014 0.0062
Onchocerca volvulus Protein patched homolog 0.0012 0.0004 0.0065
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0012 0.0004 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0174
Trichomonas vaginalis esterase, putative 0.0225 0.0176 0.2973
Schistosoma mansoni lamin 0.003 0.0018 0.0018
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0012 0.0004 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0016 0.0435
Brugia malayi Probable ClpP-like protease 0.0407 0.0324 0.1474
Mycobacterium tuberculosis Conserved protein 0.0225 0.0176 0.07
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0071 0.0071
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.0171 0.2878
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0089
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0032 0.0032
Entamoeba histolytica acyl-coA synthetase, putative 0.0296 0.0234 0.594
Loa Loa (eye worm) hypothetical protein 0.0069 0.0049 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0034
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Schistosoma mansoni acetyl-CoA synthetase 0.0087 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0009
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0005 0.0126
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Echinococcus multilocularis cpg binding protein 0.0032 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0017 0.0842
Leishmania major fatty acyl CoA syntetase 1, putative 0.0012 0.0004 0.0069
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0016 0.0908
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.001 0.0174
Trypanosoma cruzi cruzipain precursor, putative 0.0209 0.0163 0.9246
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0004 0.0011
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.016 0.6838
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0407 0.0324 0.0324
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Onchocerca volvulus 0.0739 0.0592 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0064 0.0253
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0034
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0002 0.0002
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0002 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 4 0.0012 0.0004 0.0004
Brugia malayi tailless protein 0.001 0.0002 0.0008
Leishmania major cathepsin L-like protease 0.0209 0.0163 0.6946
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Onchocerca volvulus 0.0037 0.0024 0.0397
Giardia lamblia Replication factor C, subunit 1 0.002 0.001 0.0212
Brugia malayi hypothetical protein 0.0027 0.0016 0.0073
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0057 0.3208
Brugia malayi hypothetical protein 0.0012 0.0004 0.0017
Echinococcus granulosus cysteine protease 0.0028 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0048
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Trypanosoma brucei unspecified product 0.0032 0.002 0.1026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0017 0.0842
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0004
Brugia malayi Pre-SET motif family protein 0.0649 0.052 0.2368
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.004 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0163 0.9246
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0002 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0007 0.0375
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0002
Brugia malayi protein C24B5.3 0.0012 0.0004 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.001 0.0048
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0049 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.001 0.001
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.001 0.0174
Schistosoma mansoni ap endonuclease 0.0018 0.0009 0.0009
Brugia malayi Patched related family protein 4 0.0012 0.0004 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0038 0.0644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0038 0.0644
Brugia malayi hypothetical protein 0.001 0.0002 0.0008
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0002 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.001 0.0339
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0032 0.1699
Toxoplasma gondii endonuclease IV APN 0.0093 0.0069 0.2078
Plasmodium vivax ATP-dependent acyl-CoA synthetase, putative 0.0012 0.0004 0.005
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0006 0.0203
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0012 0.0004 0.0204
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.001 0.0584
Loa Loa (eye worm) cathepsin B 0.001 0.0002 0.0009
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0017 0.0017
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0032 0.0533
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.0083 0.0083
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0017 0.0946
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0209 0.0163 0.0649
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0004 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.001 0.001
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.001 0.0244
Loa Loa (eye worm) PHD-finger family protein 0.002 0.001 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0047
Schistosoma mansoni hypothetical protein 0.0032 0.002 0.002
Trichomonas vaginalis AMP dependent ligase, putative 0.0012 0.0004 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0038 0.0644
Plasmodium vivax acetyl-CoA synthetase, putative 0.0087 0.0064 0.1935
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0012 0.0004 0.0204
Loa Loa (eye worm) patched family protein 0.0012 0.0004 0.0017
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0013 0.0013
Plasmodium vivax unspecified product 0.0028 0.0017 0.0456
Schistosoma mansoni cpg binding protein 0.0032 0.0019 0.0019
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.016 0.6838
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0012 0.0004 0.0204
Onchocerca volvulus 0.0296 0.0234 0.3943
Onchocerca volvulus 0.0055 0.0038 0.0644
Echinococcus granulosus intermediate filament protein 0.003 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0047
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0002
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.016 0.4078
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.003 0.0905
Brugia malayi Latrophilin receptor protein 2 0.0032 0.002 0.0089
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0009 0.0148
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 0.0012 0.0004 0.0004
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0012 0.0004 0.0004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0007 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0225 0.0176 0.0176
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0032 0.0803
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0209 0.0163 0.0649
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0055 0.3041
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0032 0.1277
Loa Loa (eye worm) hypothetical protein 0.0221 0.0173 0.0788
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0032 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0064 0.0253
Entamoeba histolytica cysteine proteinase 1, putative 0.0028 0.0017 0.0424
Onchocerca volvulus 0.0055 0.0038 0.0644
Onchocerca volvulus 0.0225 0.0176 0.2973
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Brugia malayi hypothetical protein 0.0012 0.0004 0.0016
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0012 0.0004 0.0204
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0038 0.2167
Loa Loa (eye worm) inositol-1 0.0045 0.003 0.0136
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0225 0.0176 0.0802
Onchocerca volvulus 0.0055 0.0038 0.0644
Schistosoma mansoni dep domain containing protein 0.0011 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.001 0.0048
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0002 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.0002 0.0034
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0008 0.0039
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0016 0.0908
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.001 0.001
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0032 0.1699
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.001 0.0339
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.001 0.0201
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0032 0.1699
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0038 0.0644
Brugia malayi MH2 domain containing protein 0.001 0.0002 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.346 0.2798 0.2798
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0012 0.0004 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0047
Schistosoma mansoni hypothetical protein 0.0133 0.0102 0.0102
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0087 0.0064 0.0253
Plasmodium falciparum cysteine proteinase falcipain 3 0.0055 0.0038 0.1125
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0002 0.0002
Echinococcus granulosus cathepsin L 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0099 0.0394
Echinococcus granulosus lamin dm0 0.003 0.0018 0.0018
Echinococcus granulosus Niemann Pick C1 protein 0.0292 0.023 0.023
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0002 0.0009
Brugia malayi N-terminal motif family protein 0.0218 0.0171 0.0777
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0296 0.0234 0.093
Brugia malayi hypothetical protein 0.0012 0.0004 0.0016
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0013 0.0013
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0015 0.0744
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0004 0.0011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.0065 0.0295
Echinococcus multilocularis lamin 0.003 0.0018 0.0018
Toxoplasma gondii ABC1 family protein 0.0225 0.0176 0.5416
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Echinococcus granulosus dna polymerase kappa 0.0047 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0187 0.0146 0.0146
Leishmania major fatty acyl CoA synthetase 2, putative 0.0012 0.0004 0.0069
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0002 0.0002
Trypanosoma brucei Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5), putative 0.0012 0.0004 0.0092
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.001 0.0048
Leishmania major cathepsin L-like protease 0.0209 0.0163 0.6946
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0012 0.0004 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0017 0.0281
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.004 0.004
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0012 0.0004 0.0011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.014 0.0107 0.3278
Leishmania major hypothetical protein, conserved 0.0225 0.0176 0.7519
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0009 0.0148
Mycobacterium ulcerans endonuclease IV 0.0093 0.0069 0.0272
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0064 0.0253
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0207 0.0162 0.0162
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0012 0.0004 0.0061
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0012 0.0004 0.0061
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.001 0.0048
Schistosoma mansoni nuclear receptor 0.001 0.0002 0.0002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.001 0.0045
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0554 0.0443 0.2017
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.001 0.0038
Brugia malayi glutaminase DH11.1 0.033 0.0261 0.1191
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 0.0012 0.0004 0.0011
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0087 0.0064 0.1633
Echinococcus multilocularis smad 0.001 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.001 0.0048
Schistosoma mansoni glutaminase 0.033 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.011 0.0083 0.0379
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0087 0.0064 0.0253
Echinococcus granulosus cathepsin l1 0.0055 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0016
Plasmodium falciparum acyl-CoA synthetase 0.0221 0.0173 0.5317
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0064 0.0253
Schistosoma mansoni cathepsin C 0.001 0.0002 0.0002
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.016 0.016
Echinococcus multilocularis acyl coenzyme A synthetase family 0.0012 0.0004 0.0004
Trypanosoma cruzi major cysteine proteinase, putative 0.001 0.0002 0.0113
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0002 0.0002
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0087 0.0064 0.3645
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0038 0.0644
Entamoeba histolytica cysteine protease, putative 0.001 0.0002 0.0051
Echinococcus granulosus disco interacting protein 2 0.0012 0.0004 0.0004
Brugia malayi hypothetical protein 0.002 0.001 0.0047
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0204 0.0159 0.405
Echinococcus granulosus GPCR family 2 0.0032 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0002 0.0008
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0002 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.001 0.0451
Onchocerca volvulus 0.0012 0.0004 0.0065
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.001 0.001
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0015 0.0403
Plasmodium vivax patched family protein, putative 0.0012 0.0004 0.0057
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.004 0.1184
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0002 0.0002
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0102 0.0102
Echinococcus granulosus neuropeptide s receptor 0.0516 0.0412 0.0412
Entamoeba histolytica cysteine protease, putative 0.001 0.0002 0.0051
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0002 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.001 0.0048
Mycobacterium ulcerans acetyl-CoA synthetase 0.0087 0.0064 0.0253
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0002 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0032 0.1793
Brugia malayi intermediate filament protein 0.003 0.0018 0.0082
Echinococcus multilocularis musashi 0.003 0.0018 0.0018
Mycobacterium ulcerans beta-lactamase 0.0225 0.0176 0.07
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.0038 0.0038
Plasmodium vivax unspecified product 0.0018 0.0008 0.0202
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0071 0.0324
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0018 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0071 0.0071
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0011
Onchocerca volvulus Cathepsin F homolog 0.0055 0.0038 0.0644
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.0038 0.0038
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0073
Trypanosoma brucei fatty acyl CoA synthetase, putative 0.0012 0.0004 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.001 0.001
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0012 0.0316
Brugia malayi cDNA sequence BC018371 0.0012 0.0004 0.0016
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.0065 0.0065
Schistosoma mansoni nuclear receptor 0.001 0.0002 0.0002
Brugia malayi cathepsin L-like precursor 0.0037 0.0024 0.0107
Trichomonas vaginalis mercuric reductase, putative 0.002 0.001 0.0166
Brugia malayi cahepsin L-like non-peptiedase homolog 0.001 0.0002 0.0009
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0012 0.0004 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0009 0.0173
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Echinococcus multilocularis ferritin 0.0009 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.002 0.1026
Brugia malayi Smad1 0.001 0.0002 0.0008
Brugia malayi Cathepsin L-like precursor 0.0055 0.0038 0.0174
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0267 0.021 0.0835
Schistosoma mansoni smad1 5 8 and 0.001 0.0002 0.0002
Schistosoma mansoni zinc finger protein 0.001 0.0002 0.0002
Schistosoma mansoni survival motor neuron protein 0.0554 0.0443 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Onchocerca volvulus 0.0087 0.0064 0.1084
Loa Loa (eye worm) hypothetical protein 0.0087 0.0064 0.0292
Loa Loa (eye worm) ctsf protein 0.0055 0.0038 0.0174
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0069 0.2078
Brugia malayi Patched related family protein 10 0.0012 0.0004 0.0017
Leishmania major acetyl-CoA synthetase, putative 0.0087 0.0064 0.2686
Trypanosoma brucei trypanothione reductase 0.0057 0.004 0.2187
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.001 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.002 0.002
Plasmodium vivax glutathione reductase, putative 0.0057 0.004 0.1184
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0017 0.0424
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.001 0.0002 0.0034
Leishmania major hypothetical protein, unknown function 0.0012 0.0004 0.0069
Brugia malayi Niemann-Pick C1 protein precursor 0.0204 0.0159 0.0726
Echinococcus granulosus long chain fatty acid transport protein 4 0.0012 0.0004 0.0004
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0002 0.0002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0004 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0225 0.0176 0.5416
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0004 0.0011
Echinococcus multilocularis cathepsin b 0.001 0.0002 0.0002
Onchocerca volvulus 0.0021 0.001 0.0177
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.001 0.0339
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0032 0.1699
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0009 0.0222
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0087 0.0064 0.0253
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0015 0.056
Schistosoma mansoni hypothetical protein 0.0084 0.0062 0.0062
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0006 0.0006
Echinococcus multilocularis neuropeptide s receptor 0.0516 0.0412 0.0412
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0493 0.0393 0.6639
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0087 0.0064 0.3573
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0038 0.0644
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.016 0.2707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0038 0.0644
Schistosoma mansoni apoferritin-2 0.0009 0.0001 0.0001
Brugia malayi beta-lactamase family protein 0.0225 0.0176 0.0802
Brugia malayi Myosin head containing protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0048
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0267 0.021 0.0835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0071 0.0071
Schistosoma mansoni flap endonuclease-1 0.0024 0.0013 0.0013
Giardia lamblia Long chain fatty acid CoA ligase, putative 0.0012 0.0004 0.0041
Loa Loa (eye worm) oxidoreductase 0.0087 0.0064 0.0292
Brugia malayi AMP-binding enzyme family protein 0.0087 0.0064 0.0292
Onchocerca volvulus 0.002 0.001 0.0174
Loa Loa (eye worm) hypothetical protein 0.0038 0.0024 0.0111
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.001 0.0559
Toxoplasma gondii patched family protein 0.0012 0.0004 0.0057
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0008 0.0481
Brugia malayi nuclear receptor RXR 0.001 0.0002 0.0008
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0087 0.0064 0.0253
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.016 0.0637
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.001 0.0559
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0006
Echinococcus granulosus cathepsin l1 0.0037 0.0024 0.0024
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.016 0.9105
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0047
Leishmania major DNA polymerase eta, putative 0.0045 0.003 0.1229
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0032 0.1699
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0087 0.0064 0.0253
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0087 0.0064 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0004
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.003 0.1729
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0296 0.0234 0.093
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0002 0.0011
Brugia malayi hypothetical protein 0.049 0.0391 0.1783
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1437 0.1159 0.4623
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0014 0.0051
Echinococcus multilocularis cathepsin L 0.001 0.0002 0.0002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0099 0.0394
Giardia lamblia Hypothetical protein 0.0012 0.0004 0.0041
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.082 0.0658 0.2624
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0267 0.021 0.0835
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Loa Loa (eye worm) hypothetical protein 0.0087 0.0064 0.0292
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.016 0.016
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Schistosoma mansoni ferritin light chain 0.0009 0.0001 0.0001
Schistosoma mansoni bromodomain containing protein 0.0064 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0017 0.0281
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.0069 0.0313
Loa Loa (eye worm) Smad1 0.001 0.0002 0.0008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0002 0.0002
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Entamoeba histolytica cysteine protease, putative 0.0028 0.0017 0.0424
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.001 0.0559
Entamoeba histolytica hypothetical protein 0.049 0.0391 0.995
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0064 0.0253
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.0319 0.0319
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0043 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0075 0.0342
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0012 0.0004 0.0011
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0012 0.0004 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0493 0.0393 0.6639
Echinococcus granulosus peptidase Clp S14 family 0.0267 0.021 0.021
Onchocerca volvulus 0.0087 0.0064 0.1084
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Schistosoma mansoni ferritin 0.0009 0.0001 0.0001
Brugia malayi beta-lactamase 0.0225 0.0176 0.0802
Leishmania major hypothetical protein, conserved 0.0027 0.0016 0.0604
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.003 0.0506
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.007 0.007
Brugia malayi Muscleblind-like protein 0.0157 0.0121 0.0553
Brugia malayi hypothetical protein 0.0012 0.0004 0.0017
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.001 0.001
Brugia malayi Pre-SET motif family protein 0.0094 0.007 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0174
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.0024 0.0107
Brugia malayi Cathepsin L-like precursor 0.0055 0.0038 0.0174
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0012 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0296 0.0234 0.1064
Brugia malayi AMP-binding enzyme family protein 0.0296 0.0234 0.1064
Mycobacterium ulcerans transcriptional regulator 0.3099 0.2506 1
Treponema pallidum DNA ligase (lig) 0.002 0.001 0.0243
Brugia malayi Patched family protein 0.0012 0.0004 0.0017
Schistosoma mansoni FFA transport protein 0.0012 0.0004 0.0004
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.001 0.0002 0.0002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0225 0.0176 0.0176
Brugia malayi CHE-14 protein 0.0088 0.0065 0.0295
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0004 0.005
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0016 0.0435
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0012 0.0004 0.0061
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0012 0.0004 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.001 0.0177
Schistosoma mansoni Smad4 0.001 0.0002 0.0002
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0004 0.0091
Mycobacterium leprae Putative polyketide synthetase Pks16 0.0012 0.0004 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0032 0.1699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0163 0.9238
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Schistosoma mansoni DNA helicase recq5 0.0011 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.001 0.0002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0221 0.0173 0.0788
Echinococcus granulosus cathepsin L cysteine proteinase 0.0055 0.0038 0.0038
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0017 0.0076
Echinococcus multilocularis protein patched 0.0088 0.0065 0.0065
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0003 0.0003
Mycobacterium ulcerans AcrR family transcriptional regulator 0.3099 0.2506 1
Trypanosoma brucei fatty acyl CoA synthetase 2 0.0012 0.0004 0.0092
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.001 0.0451
Loa Loa (eye worm) hypothetical protein 0.0206 0.016 0.0731
Mycobacterium ulcerans epimerase 0.0024 0.0014 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0004 0.0016
Brugia malayi ecdysteroid receptor 0.0021 0.001 0.0048
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 0.0012 0.0004 0.0004
Schistosoma mansoni smad1 5 8 and 0.001 0.0002 0.0002
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0006 0.0025
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0007 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.001 0.0559
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.001 0.0174
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.016 0.2707
Brugia malayi hypothetical protein 0.0011 0.0002 0.0011
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0225 0.0176 0.0802
Mycobacterium tuberculosis Probable fatty acyl-AMP ligase MbtM 0.0012 0.0004 0.0011
Onchocerca volvulus 0.0087 0.0064 0.1084
Brugia malayi nuclear receptor NHR-88 0.0021 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0012
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0087 0.0064 0.0253
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.001 0.001
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.001 0.0002 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0111 0.0504
Echinococcus multilocularis disco interacting protein 2 0.0012 0.0004 0.0004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.001 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0071 0.0324
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.001 0.0177
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0012 0.0004 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0203
Schistosoma mansoni hypothetical protein 0.0554 0.0443 0.0443
Schistosoma mansoni ap endonuclease 0.0018 0.0009 0.0009
Schistosoma mansoni transcription factor LCR-F1 0.049 0.0391 0.0391
Schistosoma mansoni DNA ligase IV 0.002 0.001 0.001
Brugia malayi hypothetical protein 0.0011 0.0002 0.0011
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.003 0.1207
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0004 0.0011
Schistosoma mansoni inositol monophosphatase 0.0045 0.003 0.003
Entamoeba histolytica cysteine protease, putative 0.001 0.0002 0.0051
Trichomonas vaginalis glutaminase, putative 0.033 0.0261 0.4412
Onchocerca volvulus 0.0012 0.0004 0.0065
Leishmania major cathepsin L-like protease 0.0209 0.0163 0.6946

Activities

Activity type Activity value Assay description Source Reference
Inhibition (ADMET) = 108.5926061 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 123.3250353 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Potency (functional) = 0.0224 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) = 0.0224 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 0.0224 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV. (Class of assay: confirmatory) [Related pubchem assays: 1705, 1707 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.003 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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