Detailed information for compound 1860938

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.901 | Formula: C19H21ClN2S
  • H donors: 0 H acceptors: 0 LogP: 5.24 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)N(C1CN(C1)C(C)(C)C)c1c(S2)cccc1
  • InChi: 1S/C19H21ClN2S/c1-19(2,3)21-11-14(12-21)22-15-6-4-5-7-17(15)23-18-9-8-13(20)10-16(18)22/h4-10,14H,11-12H2,1-3H3
  • InChiKey: SGJXQZZWGAROBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0036 0.0384 0.0384
Loa Loa (eye worm) cytochrome P450 0.0009 0.0049 0.004
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0069 0.0068
Schistosoma mansoni amine GPCR 0.0008 0.0033 0.0032
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0124 0.0123
Onchocerca volvulus 0.0162 0.1944 0.2263
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0069 0.0068
Schistosoma mansoni amine GPCR 0.0008 0.0033 0.0032
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.0427 0.0487
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Onchocerca volvulus 0.004 0.0427 0.0467
Brugia malayi Cytochrome P450 family protein 0.0009 0.0049 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0427 0.1496
Trichomonas vaginalis chaperonin, putative 0.0015 0.0123 0.0629
Brugia malayi Retinol dehydrogenase 12 0.0015 0.0124 0.0129
Onchocerca volvulus 0.0015 0.0124 0.0108
Schistosoma mansoni coup transcription factor 0.0162 0.1944 0.1943
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0184 0.0575
Trypanosoma brucei beta lactamase 0.0075 0.0861 0.9698
Schistosoma mansoni smad1 5 8 and 0.0009 0.0042 0.0041
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0046 0.0049
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.0069 0.0264
Echinococcus multilocularis cysteine protease 0.002 0.0183 0.057
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0063
Mycobacterium tuberculosis Possible oxidoreductase 0.0035 0.0362 0.0564
Echinococcus multilocularis retinol dehydrogenase 11 0.0015 0.0124 0.0347
Leishmania major cytochrome p450-like protein 0.0009 0.0049 0.0549
Loa Loa (eye worm) oxidoreductase 0.0015 0.0124 0.0129
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0184 0.1092
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0183 0.0198
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0008 0.0033 0.0032
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0015 0.0124 0.0635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0027 0.0268 0.7306
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0008 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0362 0.041
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0015 0.0124 0.0016
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0015 0.0124 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0183 0.1028
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.0427 0.0487
Onchocerca volvulus 0.0027 0.0263 0.0272
Schistosoma mansoni hypothetical protein 0.0008 0.0033 0.0032
Echinococcus multilocularis protoporphyrinogen oxidase 0.0035 0.0362 0.125
Schistosoma mansoni thyroid hormone receptor 0.0162 0.1944 0.1943
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0124 0.0347
Brugia malayi Dopamine receptor 0.0008 0.0033 0.0021
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0124 0.0347
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0124 0.0635
Brugia malayi T-complex protein 1, beta subunit 0.0015 0.0123 0.0128
Leishmania major hypothetical protein, conserved 0.0015 0.0124 0.1398
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0035 0.0362 0.0523
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0061 0.006
Loa Loa (eye worm) nuclear hormone receptor 0.004 0.0427 0.0487
Schistosoma mansoni growth hormone secretagogue receptor 0.0008 0.0033 0.0032
Brugia malayi nuclear hormone receptor 0.0162 0.1944 0.2279
Brugia malayi dehydrogenases, short chain protein 2 0.0015 0.0124 0.0129
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0046 0.0049
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0122 0.1449 0.1695
Schistosoma mansoni hypothetical protein 0.0009 0.0049 0.0048
Toxoplasma gondii aldehyde dehydrogenase 0.0044 0.048 0.6171
Mycobacterium leprae Probable oxidoreductase 0.0015 0.0124 0.0928
Schistosoma mansoni aldehyde dehydrogenase 0.0044 0.048 0.0479
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0069 0.0036
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0015 0.0124 0.0129
Brugia malayi Smad1 0.0009 0.0042 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0044 0.048 0.0479
Brugia malayi MH1 domain containing protein 0.0009 0.0042 0.0031
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0427 0.1496
Brugia malayi MH2 domain containing protein 0.0009 0.0042 0.0031
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0162 0.1944 0.2279
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0061 0.006
Echinococcus granulosus expressed protein 0.0018 0.0155 0.0466
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0073 0.0841 0.3068
Loa Loa (eye worm) oxidoreductase 0.0015 0.0124 0.0129
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.0841 0.1323
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0681 0.436
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0027 0.0268 0.3451
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0015 0.0124 0.6739
Entamoeba histolytica myo-inositol monophosphatase, putative 0.002 0.0179 0.1121
Brugia malayi acetyltransferase, GNAT family protein 0.0092 0.1076 0.1254
Trypanosoma cruzi cysteine protease, putative 0.001 0.0061 0.069
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Brugia malayi Carboxylesterase family protein 0.0011 0.0069 0.0063
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.1044 0.3839
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0027 0.0268 0.3451
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0015 0.0124 0.0928
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0183 0.0198
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0075 0.0861 0.1461
Echinococcus multilocularis retinol dehydrogenase 11 0.0015 0.0124 0.0347
Trypanosoma brucei cytochrome P450, putative 0.0009 0.0049 0.0549
Entamoeba histolytica hypothetical protein 0.0015 0.0124 0.0598
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0183 0.0182
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Schistosoma mansoni inositol monophosphatase 0.002 0.0179 0.0178
Schistosoma mansoni inositol monophosphatase 0.002 0.0179 0.0178
Leishmania major cathepsin L-like protease 0.002 0.0183 0.206
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0015 0.0124 0.0635
Schistosoma mansoni hypothetical protein 0.001 0.0057 0.0056
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.0033 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0122 0.1449 0.1695
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0124 0.0635
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0184 0.1169
Loa Loa (eye worm) hypothetical protein 0.0035 0.0362 0.041
Echinococcus multilocularis expressed protein 0.0018 0.0155 0.0466
Brugia malayi cathepsin L-like precursor 0.0013 0.01 0.01
Schistosoma mansoni zinc finger protein 0.004 0.0427 0.0426
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0035 0.0362 0.0361
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0072 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0033 0.0032
Trypanosoma cruzi short chain dehydrogenase, putative 0.0015 0.0124 0.1398
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.0033 0.0021
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0162 0.1944 0.7255
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0124 0.0347
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.0124 0.0598
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0124 0.0123
Echinococcus granulosus cpg binding protein 0.0036 0.0384 0.1335
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0162 0.1944 0.7255
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0183 0.057
Brugia malayi Muscleblind-like protein 0.008 0.0931 0.1082
Schistosoma mansoni RAR-like nuclear receptor 0.0162 0.1944 0.1943
Schistosoma mansoni cytochrome P450 0.0009 0.0049 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.0841 0.1323
Giardia lamblia Kinase, PLK 0.006 0.0681 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0009 0.0049 0.0549
Onchocerca volvulus Cathepsin L homolog 0.002 0.0183 0.0178
Loa Loa (eye worm) fibroinase 0.002 0.0183 0.0198
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Entamoeba histolytica acetyltransferase, GNAT family 0.0025 0.024 0.1706
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0183 0.1157
Mycobacterium ulcerans short-chain dehydrogenase 0.0015 0.0124 0.0126
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0015 0.0124 0.0136
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0015 0.0124 0.1398
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Chlamydia trachomatis protoporphyrinogen oxidase 0.0035 0.0362 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0015 0.0123 0.0343
Brugia malayi Dehydrogenases, short chain protein 30 0.0015 0.0124 0.0129
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0162 0.1944 0.2279
Entamoeba histolytica serine/threonine protein kinase, putative 0.006 0.0681 0.5902
Loa Loa (eye worm) inositol-1 0.002 0.0179 0.0194
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0124 0.1398
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0015 0.0124 0.0108
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0049 0.0549
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Schistosoma mansoni amine GPCR 0.0008 0.0033 0.0032
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0141 0.014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0033 0.0032
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0018 0.0155 0.0166
Loa Loa (eye worm) carboxylesterase 0.0011 0.0069 0.0063
Echinococcus granulosus cysteine protease 0.001 0.0061 0.0108
Trypanosoma cruzi polo-like protein kinase, putative 0.006 0.0681 0.7677
Echinococcus granulosus serine:threonine protein kinase PLK1 0.006 0.0681 0.2462
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Echinococcus multilocularis smad 0.0009 0.0042 0.0033
Echinococcus granulosus neuroligin 0.0011 0.0069 0.0136
Brugia malayi nuclear receptor NHR-88 0.0162 0.1944 0.2279
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.002 0.0179 0.9725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0033 0.0032
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0015 0.0124 0.0123
Mycobacterium ulcerans short-chain dehydrogenase 0.0015 0.0124 0.0126
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0015 0.0124 0.0598
Schistosoma mansoni ap endonuclease 0.002 0.0184 0.0183
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0015 0.0123 0.0122
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Schistosoma mansoni alpha-1 adrenergic receptor 0.0008 0.0033 0.0032
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0122 0.1449 0.1695
Mycobacterium tuberculosis Possible oxidoreductase 0.0015 0.0124 0.0136
Schistosoma mansoni carbonyl reductase 0.0015 0.0124 0.0123
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0015 0.0124 0.0129
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0048 0.0532 0.3362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0061 0.069
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Leishmania major cytochrome p450-like protein 0.0009 0.0049 0.0549
Echinococcus granulosus cathepsin l1 0.002 0.0183 0.057
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0681 0.436
Echinococcus multilocularis muscleblind protein 0.008 0.0931 0.3409
Leishmania major short chain dehydrogenase-like protein 0.0015 0.0124 0.1398
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.1595
Echinococcus multilocularis neuroligin 0.0011 0.0069 0.0136
Brugia malayi Nuclear hormone receptor E75 0.004 0.0427 0.0487
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0015 0.0124 0.1398
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0015 0.0124 0.0108
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0124 0.0123
Leishmania major short chain dehydrogenase, putative 0.0015 0.0124 0.1398
Onchocerca volvulus 0.004 0.0427 0.0467
Loa Loa (eye worm) hypothetical protein 0.0035 0.0362 0.041
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Schistosoma mansoni Smad4 0.0009 0.0042 0.0041
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0033 0.0032
Brugia malayi dehydrogenases, short chain protein 9 0.0015 0.0124 0.0129
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0033 0.0032
Brugia malayi latrophilin 2 splice variant baaae 0.0022 0.0201 0.022
Schistosoma mansoni retinal dehydrogenase 0.0015 0.0124 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0681 0.436
Loa Loa (eye worm) hypothetical protein 0.0013 0.01 0.01
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0015 0.0123 0.0343
Schistosoma mansoni opsin-like receptor 0.0008 0.0033 0.0032
Brugia malayi hypothetical protein 0.0035 0.0362 0.041
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0069 0.0136
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0069 0.0136
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0037 0.0388 0.4988
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0042 0.0041
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0162 0.1944 0.1943
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0035 0.0362 1
Toxoplasma gondii oxidoreductase, putative 0.0015 0.0124 0.1595
Leishmania major oxidoreductase-like protein 0.0015 0.0124 0.1398
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0015 0.0124 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0155 0.0845
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0015 0.0124 0.1398
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.0033 0.0021
Brugia malayi hypothetical protein 0.0122 0.1449 0.1695
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0063
Brugia malayi MH2 domain containing protein 0.0129 0.1538 0.18
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0044 0.048 0.0776
Brugia malayi Nuclear hormone receptor-like 1 0.0122 0.1449 0.1695
Giardia lamblia Short-chain dehydrogenase, putative 0.0015 0.0124 0.0016
Onchocerca volvulus 0.0011 0.0069 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0305 0.1844
Onchocerca volvulus 0.002 0.0183 0.0178
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0136
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0126
Plasmodium falciparum T-complex protein 1 subunit beta 0.0015 0.0123 0.2058
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0887 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0015 0.0124 0.0347
Schistosoma mansoni kinase 0.0031 0.0315 0.0314
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.1538 0.18
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0183 0.1028
Schistosoma mansoni hypothetical protein 0.0022 0.0201 0.02
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0015 0.0124 0.0348
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0049 0.004
Loa Loa (eye worm) hypothetical protein 0.0065 0.074 0.0857
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0035 0.0362 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0928
Leishmania major pteridine reductase 1 0.0015 0.0124 0.1398
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0162 0.1944 0.7255
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0008 0.0033 0.0032
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.1595
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.0124 0.0598
Loa Loa (eye worm) carboxylesterase 0.0011 0.0069 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0033 0.0032
Echinococcus granulosus hypothetical protein 0.0015 0.0124 0.0347
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0538 0.0537
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0681 0.436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Trypanosoma brucei short-chain dehydrogenase, putative 0.0015 0.0124 0.1398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Brugia malayi neuropeptide F receptor 0.0008 0.0033 0.0021
Giardia lamblia Reductase, putative 0.0015 0.0124 0.0016
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0124 0.0347
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0015 0.0124 0.0347
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0162 0.1944 0.2279
Echinococcus granulosus hypothetical protein 0.0015 0.0124 0.0347
Entamoeba histolytica protein kinase, putative 0.0095 0.1112 1
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Toxoplasma gondii carbonyl reductase 1, putative 0.0015 0.0124 0.1595
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.001 0.0057 0.009
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0015 0.0124 0.1595
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0035 0.0362 0.3858
Brugia malayi SWIRM domain containing protein 0.0035 0.0362 0.041
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.1595
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0887 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0015 0.0124 0.1398
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0015 0.0124 0.0136
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Echinococcus multilocularis retinol dehydrogenase 13 0.0015 0.0124 0.0347
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0015 0.0124 0.0136
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0136
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0124 0.1398
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0015 0.0124 0.0598
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0141 0.014
Brugia malayi Cytochrome P450 family protein 0.003 0.0304 0.0341
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.0427 0.0487
Echinococcus granulosus cathepsin l1 0.0013 0.01 0.0255
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0124 0.0347
Onchocerca volvulus Cathepsin L homolog 0.002 0.0183 0.0178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.048 0.072
Brugia malayi Cathepsin L-like precursor 0.002 0.0183 0.0198
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0073 0.0841 0.3068
Loa Loa (eye worm) DR-78 0.004 0.0427 0.0487
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0008 0.0033 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0162 0.1944 0.2279
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0015 0.0124 0.0126
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0184 0.2074
Mycobacterium ulcerans short-chain dehydrogenase 0.0015 0.0124 0.0126
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.1595
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0184 0.1036
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0061 0.069
Echinococcus multilocularis protein quaking 0.0032 0.0329 0.1123
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0183 0.1028
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.008 0.0931 0.1082
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Brugia malayi Nuclear hormone receptor E75 0.004 0.0427 0.0487
Schistosoma mansoni gliotactin 0.0011 0.0069 0.0068
Brugia malayi Serotonin receptor 0.0008 0.0033 0.0021
Brugia malayi hypothetical protein 0.0008 0.0033 0.0021
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0018 0.0153 0.0188
Schistosoma mansoni opsin-like receptor 0.0008 0.0033 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0061 0.0215
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Echinococcus multilocularis 0.0035 0.0362 0.125
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0063
Brugia malayi T-complex protein 1, beta subunit 0.0015 0.0123 0.0128
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Brugia malayi Cathepsin L-like precursor 0.002 0.0183 0.0198
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0015 0.0124 0.0136
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.002 0.0179 0.2017
Echinococcus granulosus lysine specific histone demethylase 1A 0.0035 0.0362 0.125
Schistosoma mansoni histamine h1 receptor 0.0008 0.0033 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0183 0.057
Brugia malayi Pre-SET motif family protein 0.0113 0.1333 0.1558
Loa Loa (eye worm) carboxylesterase 0.0065 0.074 0.0857
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0162 0.1944 0.2279
Loa Loa (eye worm) oxidoreductase 0.0015 0.0124 0.0129
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0061 0.006
Entamoeba histolytica short chain dehydrogenase family protein 0.0015 0.0124 0.0598
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0126
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0069 0.0136
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0124 0.0136
Trypanosoma brucei short-chain dehydrogenase, putative 0.0015 0.0124 0.1398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0015 0.0124 0.0136
Brugia malayi Cathepsin L-like precursor 0.002 0.0183 0.0198
Loa Loa (eye worm) cysteine protease 0.002 0.0183 0.0198
Toxoplasma gondii peptidylprolyl isomerase 0.0018 0.015 0.193
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0015 0.0124 0.0136
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.049 0.6036 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0072 0.0148
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0015 0.0124 0.0136
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.0033 0.0021
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0073 0.0841 0.0976
Trypanosoma brucei oxidoreductase-like protein 0.0015 0.0124 0.1398
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0015 0.0124 0.0136
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.074 0.0739
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0184 0.2074
Echinococcus granulosus retinol dehydrogenase 11 0.0015 0.0124 0.0347
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0183 0.057
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0015 0.0124 0.1398
Schistosoma mansoni biogenic amine receptor 0.0008 0.0033 0.0032
Schistosoma mansoni neuropeptide receptor 0.0008 0.0033 0.0032
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0033 0.0032
Leishmania major cathepsin L-like protease 0.002 0.0183 0.206
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0681 0.436
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Echinococcus granulosus steroid dehydrogenase 0.0015 0.0124 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0092 0.1076 0.1075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0061 0.069
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Loa Loa (eye worm) hypothetical protein 0.0035 0.0362 0.041
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0183 0.4044
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.1944 0.7255
Mycobacterium ulcerans oxidoreductase 0.0015 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.0027 0.0263 0.0293
Schistosoma mansoni cpg binding protein 0.0036 0.0384 0.0384
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.01 0.01
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0162 0.1944 0.2279
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0162 0.1944 0.7255
Onchocerca volvulus 0.0011 0.0069 0.0042
Brugia malayi hypothetical protein 0.0008 0.0033 0.0021
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0015 0.0124 0.0598
Brugia malayi ORL1-like opioid receptor 0.0008 0.0033 0.0021
Echinococcus granulosus muscleblind protein 0.008 0.0931 0.3409
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0362 0.0564
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0015 0.0123 0.3117
Leishmania major short chain dehydrogenase, putative 0.0015 0.0124 0.1398
Loa Loa (eye worm) hypothetical protein 0.0122 0.1449 0.1695
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0427 0.1496
Toxoplasma gondii oxidoreductase, putative 0.0015 0.0124 0.1595
Schistosoma mansoni hypothetical protein 0.0008 0.0033 0.0032
Echinococcus granulosus carboxylesterase 5A 0.0065 0.074 0.2685
Onchocerca volvulus Protein ultraspiracle homolog 0.0162 0.1944 0.2263
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Brugia malayi serine/threonine-protein kinase plk-2 0.006 0.0681 0.0788
Brugia malayi neuropeptide F receptor 0.0008 0.0033 0.0021
Schistosoma mansoni opsin-like receptor 0.0008 0.0033 0.0032
Schistosoma mansoni nuclear receptor 0.004 0.0427 0.0426
Brugia malayi Dopamine receptor protein 1 0.0008 0.0033 0.0021
Echinococcus multilocularis steroid dehydrogenase 0.0015 0.0124 0.0347
Mycobacterium ulcerans dehydrogenase 0.0035 0.0362 0.0523
Mycobacterium ulcerans lipoprotein LpqF 0.0075 0.0861 0.1356
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.0033 0.0021
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0015 0.0124 0.0598
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0778 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.0183 0.0178
Echinococcus multilocularis acetylcholinesterase 0.0065 0.074 0.2685
Trypanosoma brucei short-chain dehydrogenase, putative 0.0015 0.0124 0.1398
Schistosoma mansoni hypothetical protein 0.0091 0.1065 0.1064
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0015 0.0124 0.1398
Entamoeba histolytica short chain dehydrogenase family protein 0.0015 0.0124 0.0598
Toxoplasma gondii histone lysine-specific demethylase 0.0035 0.0362 0.4652
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0427 0.1496
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0362 1
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0122 0.1449 0.1695
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0162 0.1944 0.1943
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0184 0.02
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0183 0.057
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Trichomonas vaginalis set domain proteins, putative 0.0128 0.1525 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0033 0.0032
Schistosoma mansoni hypothetical protein 0.022 0.2667 0.2666
Schistosoma mansoni acetylcholinesterase 0.0011 0.0069 0.0068
Loa Loa (eye worm) hypothetical protein 0.0146 0.1752 0.2053
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0069 0.0136
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Onchocerca volvulus 0.0011 0.0069 0.0042
Leishmania major UDP-galactopyranose mutase 0.0035 0.0362 0.4079
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0015 0.0124 0.0347
Echinococcus multilocularis Smad4 0.0009 0.0042 0.0033
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0162 0.1944 0.2279
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0183 0.0198
Brugia malayi Dopamine receptor protein 2 0.0008 0.0033 0.0021
Leishmania major cathepsin L-like protease 0.0077 0.0887 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0183 0.0198
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Echinococcus multilocularis steroid dehydrogenase 0.0015 0.0124 0.0347
Brugia malayi sulfakinin receptor protein 0.0008 0.0033 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0124 0.1398
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0162 0.1944 0.7255
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0681 0.0681
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0162 0.1944 0.7255
Echinococcus granulosus cathepsin L 0.001 0.0061 0.0108
Brugia malayi hypothetical protein 0.0011 0.0069 0.0063
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0015 0.0124 0.1398
Loa Loa (eye worm) tumor suppressor 0.0377 0.462 0.5443
Echinococcus multilocularis transient receptor potential cation channel 0.0015 0.0124 0.0347
Brugia malayi conserved hypotetical protein 0.004 0.0427 0.0487
Brugia malayi hypothetical protein 0.0008 0.0033 0.0021
Loa Loa (eye worm) oxidoreductase 0.0015 0.0124 0.0129
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Schistosoma mansoni cpg binding protein 0.0034 0.036 0.0359
Onchocerca volvulus 0.0015 0.0124 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0063
Brugia malayi nuclear receptor NHR-88 0.004 0.0427 0.0487
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0008 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Brugia malayi Cytochrome P450 family protein 0.0009 0.0049 0.004
Leishmania major cytochrome p450-like protein 0.0009 0.0049 0.0549
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0061 0.069
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0015 0.0124 0.1398
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Onchocerca volvulus 0.0015 0.0124 0.0108
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.001 0.0057 0.0049
Brugia malayi Cathepsin L-like precursor 0.002 0.0183 0.0198
Trypanosoma cruzi UDP-galactopyranose mutase 0.0035 0.0362 0.4079
Loa Loa (eye worm) dehydrogenase 0.0015 0.0124 0.0129
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0184 0.0244
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0268 0.1601
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0124 0.0123
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0069 0.0136
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0124 0.1398
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0124 0.0136
Brugia malayi nuclear hormone receptor 0.004 0.0427 0.0487
Onchocerca volvulus 0.0015 0.0124 0.0108
Brugia malayi MH2 domain containing protein 0.0009 0.0042 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0532 0.3362
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0015 0.0124 0.0598
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0184 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0049 0.004
Plasmodium vivax vivapain-2 0.002 0.0183 0.4838
Echinococcus multilocularis oxidoreductase 0.0015 0.0124 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0061 0.0215
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0124 0.0136
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0015 0.0123 0.1388
Echinococcus multilocularis geminin 0.0091 0.1065 0.3919
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0008 0.0033 0.0032
Mycobacterium ulcerans dehydrogenase/reductase 0.0015 0.0124 0.0126
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0113 0.1333 0.1558
Brugia malayi Steroid receptor seven-up type 2 0.0162 0.1944 0.2279
Loa Loa (eye worm) hypothetical protein 0.0032 0.0326 0.0367
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0162 0.1944 0.1943
Brugia malayi nuclear receptor NHR-67 0.004 0.0427 0.0487
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0141 0.0411
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0141 0.014
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0015 0.0123 0.0122
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Onchocerca volvulus 0.0015 0.0124 0.0108
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.0427 0.0487
Trypanosoma brucei polo-like protein kinase 0.006 0.0681 0.7677
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0184 0.4085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0362 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0015 0.0124 0.0347
Plasmodium falciparum protoporphyrinogen oxidase 0.0035 0.0362 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.002 0.0179 0.2017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0162 0.1944 0.7255
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0162 0.1944 0.7255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0015 0.0124 0.1398
Loa Loa (eye worm) hypothetical protein 0.0122 0.1449 0.1695
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0027 0.0268 0.1601
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.002 0.0179 0.2017
Schistosoma mansoni amine oxidase 0.0035 0.0362 0.0361
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0427 0.1496
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0122 0.1449 0.5377
Brugia malayi photoreceptor-specific nuclear receptor 0.0162 0.1944 0.2279
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0162 0.1944 0.7255
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0162 0.1944 0.2279
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0015 0.0124 0.0635
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.0427 0.0487
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.01 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0162 0.1944 0.2279
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0126
Echinococcus multilocularis cysteine protease 0.002 0.0183 0.057
Loa Loa (eye worm) hypothetical protein 0.0162 0.1944 0.2279
Plasmodium vivax vivapain-1 0.001 0.0061 0.1334
Schistosoma mansoni adenoreceptor 0.0008 0.0033 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0184 0.0226
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0015 0.0123 0.1388
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0046 0.0045
Trichomonas vaginalis steroid dehydrogenase, putative 0.0015 0.0124 0.0635
Schistosoma mansoni myosin xvIII 0.0008 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0015 0.0124 0.2088
Mycobacterium ulcerans ketoacyl reductase 0.0015 0.0124 0.0126
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0073 0.0841 0.9476
Loa Loa (eye worm) hypothetical protein 0.0162 0.1944 0.2279
Leishmania major cathepsin L-like protease 0.002 0.0183 0.206
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0061 0.0108
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0124 0.0123
Plasmodium vivax unspecified product 0.001 0.0061 0.1334
Loa Loa (eye worm) CYP4Cod1 0.0009 0.0049 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0887 1
Onchocerca volvulus 0.0015 0.0124 0.0108
Loa Loa (eye worm) hypothetical protein 0.002 0.0183 0.0198
Brugia malayi CXXC zinc finger family protein 0.0034 0.036 0.0408
Leishmania major short chain dehydrogenase/reductase, putative 0.0015 0.0124 0.1398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Echinococcus multilocularis GPCR, family 2 0.001 0.0057 0.009
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0126
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0427 0.0467
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0162 0.1944 0.2279
Schistosoma mansoni carbonyl reductase 0.0015 0.0124 0.0123
Onchocerca volvulus 0.002 0.0183 0.0178
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0183 0.057
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0042 0.0033
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0015 0.0124 0.1398
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0042 0.0033
Brugia malayi MH1 domain containing protein 0.0009 0.0042 0.0031
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0075 0.0861 1
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.0069 0.0264
Leishmania major hypothetical protein, conserved 0.0015 0.0124 0.1398
Onchocerca volvulus 0.0015 0.0124 0.0108
Echinococcus granulosus dnaJ subfamily B 0.022 0.2667 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0015 0.0124 0.0129
Loa Loa (eye worm) hypothetical protein 0.0022 0.0201 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0124 0.1398
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.0427 0.0487
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0183 0.4044
Brugia malayi Inositol-1 0.002 0.0179 0.0194
Toxoplasma gondii cytochrome p450 superfamily protein 0.0009 0.0049 0.0626
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0073 0.0841 0.1426
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.006 0.0681 0.7677
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0124 0.0123
Plasmodium vivax vivapain-2 0.002 0.0183 0.4838
Giardia lamblia Histone acetyltransferase GCN5 0.0025 0.024 0.2102
Echinococcus granulosus WW domain containing oxidoreductase 0.0015 0.0124 0.0347
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0042 0.0033
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0015 0.0124 0.1398
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0015 0.0124 0.1398
Onchocerca volvulus 0.002 0.0183 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0032 0.0329 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0183 0.1028
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Mycobacterium ulcerans monoamine oxidase 0.0035 0.0362 0.0523
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0124 0.0123
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0124 0.0635
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0033 0.0032
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.004 0.0427 0.1496
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.074 0.2685
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0124 0.1398
Echinococcus granulosus histone acetyltransferase KAT2B 0.0027 0.0268 0.0895
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.006 0.0681 0.0788
Brugia malayi hypothetical protein 0.0122 0.1449 0.1695
Mycobacterium tuberculosis Probable dehydrogenase 0.0015 0.0124 0.0136
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0015 0.0123 0.0589
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0184 0.1036
Brugia malayi RE15519p 0.0008 0.0033 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0183 0.1028
Brugia malayi G protein-coupled receptor 0.0008 0.0033 0.0021
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0035 0.0362 0.0361
Leishmania major short chain dehydrogenase/reductase, putative 0.0015 0.0124 0.1398
Brugia malayi Carboxylesterase family protein 0.0065 0.074 0.0857
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0015 0.0124 0.0129
Onchocerca volvulus 0.0015 0.0124 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0162 0.1944 0.2279
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0126
Onchocerca volvulus 0.0015 0.0124 0.0108
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Loa Loa (eye worm) oxidoreductase 0.0015 0.0124 0.0129
Onchocerca volvulus 0.0034 0.036 0.0387
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0124 0.0123
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0124 0.0347
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0069 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0183 0.1028
Plasmodium vivax steroid dehydrogenase, putative 0.0015 0.0124 0.3143
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0183 0.0182
Schistosoma mansoni biogenic amine (5HT) receptor 0.0146 0.1752 0.1751
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0042 0.0031
Echinococcus granulosus lysine specific histone demethylase 1A 0.0035 0.0362 0.125
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Onchocerca volvulus 0.002 0.0183 0.0178
Schistosoma mansoni hypothetical protein 0.0032 0.0329 0.0328
Echinococcus multilocularis FTZ F1 alpha 0.0162 0.1944 0.7255
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0126
Brugia malayi hypothetical protein 0.0008 0.0033 0.0021
Trichomonas vaginalis rotamase, putative 0.0018 0.015 0.081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0162 0.1944 0.1943
Echinococcus granulosus geminin 0.0091 0.1065 0.3919
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0015 0.0124 0.0347
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0015 0.0124 0.1398
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0122 0.1449 0.1448
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0095 0.1112 0.4097
Brugia malayi putative neuropeptide receptor 0.0008 0.0033 0.0021
Brugia malayi hypothetical protein 0.004 0.0427 0.0487
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.0427 0.1496
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0183 0.1028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0032 0.0326 0.0367
Onchocerca volvulus Serine\/threonine kinase homolog 0.006 0.0681 0.0768
Trichomonas vaginalis myo inositol monophosphatase, putative 0.002 0.0179 0.1003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Trichomonas vaginalis rotamase, putative 0.0018 0.0155 0.0845
Brugia malayi Carboxylesterase family protein 0.0011 0.0069 0.0063
Onchocerca volvulus 0.0015 0.0124 0.0108
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0184 0.2074
Brugia malayi Cytochrome P450 family protein 0.0009 0.0049 0.004
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0009 0.0049 0.0549
Onchocerca volvulus 0.0012 0.0081 0.0057
Echinococcus granulosus retinol dehydrogenase 11 0.0015 0.0124 0.0347
Schistosoma mansoni smad 0.0009 0.0042 0.0041
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0018 0.0155 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.1944 0.2279
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0304 0.0341
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.048 0.072
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.0427 0.1496
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Onchocerca volvulus 0.0128 0.1525 0.1768
Mycobacterium ulcerans dehydrogenase 0.0015 0.0124 0.0126
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.002 0.0179 0.2017
Onchocerca volvulus 0.0015 0.0124 0.0108
Schistosoma mansoni hypothetical protein 0.0008 0.0033 0.0032
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.015 0.0846
Echinococcus granulosus acetylcholinesterase 0.0065 0.074 0.2685
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0008 0.0033 0.0032
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0015 0.0124 0.1398
Onchocerca volvulus 0.0011 0.0069 0.0042
Loa Loa (eye worm) hypothetical protein 0.0065 0.074 0.0857
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0033 0.0032
Mycobacterium ulcerans carveol-like dehydrogenase 0.0015 0.0124 0.0126
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.0427 0.0426
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0061 0.069
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0018 0.015 0.1692
Loa Loa (eye worm) Smad1 0.0009 0.0042 0.0031
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Echinococcus granulosus protein quaking 0.0032 0.0329 0.1123
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0136
Onchocerca volvulus Sepiapterin reductase homolog 0.0015 0.0124 0.0108
Onchocerca volvulus 0.002 0.0183 0.0178
Brugia malayi Cathepsin L-like precursor 0.002 0.0183 0.0198
Loa Loa (eye worm) ctsf protein 0.002 0.0183 0.0198
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0124 0.0136
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0649 0.0749
Brugia malayi nuclear receptor RXR 0.0122 0.1449 0.1695
Echinococcus multilocularis acetylcholinesterase 0.0065 0.074 0.2685
Leishmania major hypothetical protein, conserved 0.0015 0.0124 0.1398
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0015 0.0124 0.0126
Echinococcus granulosus cytochrome P450 2K1 0.0009 0.0049 0.0061
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.0033 0.0021
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0184 0.0575
Schistosoma mansoni biogenic amine receptor 0.0008 0.0033 0.0032
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.0427 0.1496
Echinococcus multilocularis muscleblind protein 1 0.008 0.0931 0.3409
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0427 0.1496
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0162 0.1944 0.7255
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0847 0.0846
Brugia malayi ecdysone receptor 0.004 0.0427 0.0487
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.0069 0.0036
Schistosoma mansoni hypothetical protein 0.0091 0.1065 0.1064
Loa Loa (eye worm) dehydrogenase 0.0015 0.0124 0.0129
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0183 0.1157
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0033 0.0021
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0162 0.1944 0.1943
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Schistosoma mansoni cellular tumor antigen P53 0.0027 0.0263 0.0262
Loa Loa (eye worm) hypothetical protein 0.0146 0.1752 0.2053
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.002 0.0179 0.0218
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0124 0.0123
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0033 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.01 0.0474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Brugia malayi hypothetical protein 0.0008 0.0033 0.0021
Schistosoma mansoni hypothetical protein 0.001 0.0057 0.0056
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0015 0.0124 0.0136
Plasmodium vivax SET domain protein, putative 0.0017 0.0141 0.3632
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Brugia malayi Temporarily assigned gene name protein 44 0.0032 0.0329 0.0371
Schistosoma mansoni hypothetical protein 0.0008 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0122 0.1449 0.1695
Brugia malayi tailless protein 0.004 0.0427 0.0487
Mycobacterium ulcerans oxidoreductase 0.0035 0.0362 0.0523
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0008 0.0033 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0007 0.0015 0.0169
Echinococcus granulosus FTZ F1 alpha 0.0162 0.1944 0.7255
Trypanosoma cruzi UDP-galactopyranose mutase 0.0035 0.0362 0.4079
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.0033 0.0021
Loa Loa (eye worm) steroid hormone receptor 0.0162 0.1944 0.2279
Brugia malayi Cathepsin L-like precursor 0.0013 0.01 0.01
Schistosoma mansoni nuclear hormone receptor 0.0162 0.1944 0.1943
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0044 0.048 0.541
Onchocerca volvulus Bile acid receptor homolog 0.0686 0.8475 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0018 0.015 0.1692
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0015 0.0124 0.0136
Schistosoma mansoni smad1 5 8 and 0.0009 0.0042 0.0041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0183 0.1028
Leishmania major 3-keto-dihydrosphingosine reductase 0.0015 0.0124 0.1398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0183 0.4044
Brugia malayi nuclear receptor RXR 0.004 0.0427 0.0487
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0126
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0032 0.0326 0.0367
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0018 0.015 0.1692
Toxoplasma gondii exonuclease III APE 0.002 0.0184 0.2366
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0018 0.015 0.1692
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Onchocerca volvulus 0.002 0.0183 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0033 0.0032
Brugia malayi hypothetical protein 0.0015 0.0124 0.0129
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0129
Echinococcus multilocularis dnaJ subfamily B 0.022 0.2667 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Loa Loa (eye worm) hypothetical protein 0.0162 0.1944 0.2279
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0069 0.0136
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0124 0.1398
Leishmania major T-complex protein 1, beta subunit, putative 0.0015 0.0123 0.1388
Schistosoma mansoni nuclear hormone receptor 0.004 0.0427 0.0426
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0124 0.0126
Brugia malayi G-protein coupled receptor 0.0008 0.0033 0.0021
Brugia malayi tumor suppressor. 0.0377 0.462 0.5443
Echinococcus granulosus hypothetical protein 0.0032 0.0329 0.1123
Leishmania major dehydrogenase-like protein 0.0015 0.0124 0.1398
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0124 0.0635
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0015 0.0124 0.0928
Brugia malayi Serotonin receptor 0.0008 0.0033 0.0021
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0015 0.0124 0.0108
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.0033 0.0021
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0136
Schistosoma mansoni amine oxidase 0.0035 0.0362 0.0361
Echinococcus granulosus smad 0.0009 0.0042 0.0033
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0042 0.0033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0015 0.0124 0.1398
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0017 0.0141 0.0411
Brugia malayi hypothetical protein 0.0008 0.0033 0.0021
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0805 0.9066
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0124 0.0635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0162 0.1944 0.2279
Brugia malayi Cathepsin L-like precursor 0.0013 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0126
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0183 0.206
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0681 0.436
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0162 0.1944 0.7255
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.001 0.0057 0.009
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0928
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0015 0.0123 0.0629
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0122 0.1449 0.5377
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0141 0.0411
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0035 0.0362 0.125
Mycobacterium tuberculosis Possible oxidoreductase 0.0015 0.0124 0.0136
Echinococcus multilocularis ecdysone induced protein 78C 0.0162 0.1944 0.7255
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.01 0.0099
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0008 0.0033 0.0021
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0124 0.0635
Brugia malayi steroid hormone receptor 0.0162 0.1944 0.2279
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0069 0.0068
Brugia malayi Carboxylesterase family protein 0.0011 0.0069 0.0063
Entamoeba histolytica cysteine protease, putative 0.002 0.0183 0.1157
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0044 0.048 0.1698
Plasmodium vivax vivapain-3 0.001 0.0061 0.1334
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0162 0.1944 0.2279
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.006 0.0681 0.2462
Loa Loa (eye worm) oxidoreductase 0.0015 0.0124 0.0129
Leishmania major cathepsin L-like protease 0.0077 0.0887 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.002 0.0179 0.1003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Echinococcus multilocularis serotonin receptor 0.0146 0.1752 0.6528
Schistosoma mansoni neuropeptide receptor 0.0008 0.0033 0.0032
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0042 0.0031
Brugia malayi cytochrome P450 0.0009 0.0049 0.004
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0015 0.0124 0.1398
Echinococcus granulosus ecdysone induced protein 78C 0.0162 0.1944 0.7255
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Schistosoma mansoni rotamase 0.0018 0.0155 0.0155
Trypanosoma cruzi short chain dehydrogenase, putative 0.0015 0.0124 0.1398
Schistosoma mansoni steroid hormone receptor ad4bp 0.0162 0.1944 0.1943
Loa Loa (eye worm) T-complex protein 1 0.0015 0.0123 0.0128
Plasmodium falciparum steroid dehydrogenase, putative 0.0015 0.0124 0.2088
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0069 0.0068
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0015 0.0124 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Loa Loa (eye worm) hypothetical protein 0.0162 0.1944 0.2279
Loa Loa (eye worm) IRE protein kinase 0.0095 0.1112 0.1296
Leishmania major cathepsin L-like protease 0.002 0.0183 0.206
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.1595
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0124 0.0635
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0033 0.0032
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0456 0.5606 1
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0124 0.1398
Onchocerca volvulus 0.0015 0.0124 0.0108
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.049 0.6036 1
Echinococcus multilocularis inositol monophosphatase 1 0.002 0.0179 0.0555
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0184 0.2074
Plasmodium falciparum histone acetyltransferase GCN5 0.0025 0.024 0.596
Trypanosoma brucei short-chain dehydrogenase, putative 0.0015 0.0124 0.1398
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0184 0.02
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0009 0.0049 0.0549
Loa Loa (eye worm) hypothetical protein 0.0162 0.1944 0.2279
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0122 0.1449 0.1448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0162 0.1944 0.2279
Schistosoma mansoni smad1 5 8 and 0.0009 0.0042 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0162 0.1944 0.2279
Brugia malayi amine oxidase, flavin-containing family protein 0.0035 0.0362 0.041
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0124 0.0347
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Leishmania major hypothetical protein, conserved 0.0015 0.0124 0.1398
Brugia malayi larval opioid receptor 0.0008 0.0033 0.0021
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0033 0.0021
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0061 0.0055
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Echinococcus multilocularis tumor protein p63 0.0181 0.2191 0.8195
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0015 0.0124 0.0347
Brugia malayi Melatonin receptor type 1A 0.0008 0.0033 0.0021
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Schistosoma mansoni nuclear receptor 0.004 0.0427 0.0426
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0015 0.0124 0.0123
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0184 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Onchocerca volvulus 0.0013 0.01 0.008
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0046 0.0049
Giardia lamblia Hypothetical protein 0.0015 0.0124 0.0016
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0162 0.1944 0.2263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0183 0.1028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.036 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.01 0.0474
Echinococcus multilocularis cathepsin L 0.001 0.0061 0.0108
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.002 0.0179 0.2301
Onchocerca volvulus 0.0015 0.0124 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0183 0.1028
Leishmania major hypothetical protein, conserved 0.0015 0.0124 0.1398
Brugia malayi Carboxylesterase family protein 0.0065 0.074 0.0857
Schistosoma mansoni amine GPCR 0.0008 0.0033 0.0032
Brugia malayi Latrophilin receptor protein 2 0.001 0.0057 0.0049
Brugia malayi Carboxylesterase family protein 0.0011 0.0069 0.0063
Loa Loa (eye worm) hypothetical protein 0.0162 0.1944 0.2279
Leishmania major cathepsin L-like protease 0.0077 0.0887 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0162 0.1944 0.2279
Loa Loa (eye worm) acetyltransferase 0.0092 0.1076 0.1254
Brugia malayi hypothetical protein 0.0032 0.0329 0.0371
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0033 0.0021
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0015 0.0124 0.0126
Schistosoma mansoni thyroid hormone receptor 0.0162 0.1944 0.1943
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0155 0.1867 0.3036
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0887 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0146 0.1752 0.6528
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.074 0.0857
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0069 0.0036
Echinococcus granulosus tumor protein p63 0.0181 0.2191 0.8195
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0155 0.1867 0.3271
Loa Loa (eye worm) hypothetical protein 0.0035 0.0362 0.041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0032 0.0326 0.0367
Entamoeba histolytica protein kinase, putative 0.0095 0.1112 1
Echinococcus multilocularis conserved hypothetical protein 0.0015 0.0124 0.0347
Mycobacterium ulcerans ketoacyl reductase 0.0015 0.0124 0.0126
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0124 0.0635
Brugia malayi oxidoreductase 0.0015 0.0124 0.0129
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.001 0.0057 0.009
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0015 0.0124 0.1398
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0073 0.0841 0.084
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0362 0.041
Trypanosoma cruzi major cysteine proteinase, putative 0.006 0.0683 0.7696
Schistosoma mansoni nuclear hormone receptor 0.004 0.0427 0.0426
Schistosoma mansoni amine GPCR 0.0008 0.0033 0.0032
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0015 0.0124 0.0123
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0009 0.0049 0.0549
Brugia malayi hypothetical protein 0.0008 0.0033 0.0021
Schistosoma mansoni retinoic acid receptor RXR 0.0162 0.1944 0.1943
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0162 0.1944 0.7255
Schistosoma mansoni cathepsin s 0.0007 0.0015 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0162 0.1944 0.2279
Mycobacterium ulcerans ketoacyl reductase 0.0015 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.048 0.072
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.0427 0.1496
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0063
Schistosoma mansoni hypothetical protein 0.001 0.0057 0.0056
Leishmania major cysteine peptidase A (CPA) 0.002 0.0183 0.206
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0095 0.1112 0.4097
Loa Loa (eye worm) latrophilin receptor protein 2 0.001 0.0057 0.0049
Brugia malayi hypothetical protein 0.0008 0.0033 0.0021
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0044 0.048 0.1698
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0162 0.1944 0.1943
Trypanosoma cruzi polo-like protein kinase, putative 0.006 0.0681 0.7677
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0015 0.0124 0.2088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0887 1
Brugia malayi GnHR receptor homolog 0.0008 0.0033 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0305 0.1844
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0063
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0015 0.0123 0.0122
Echinococcus multilocularis 0.0009 0.0049 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0162 0.1944 0.2279
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0162 0.1944 0.7255
Echinococcus granulosus acetylcholinesterase 0.0065 0.074 0.2685
Brugia malayi Ribonuclease 2-5A family protein 0.0095 0.1112 0.1296
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Schistosoma mansoni biogenic amine receptor 0.0008 0.0033 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0017 0.0141 0.014
Brugia malayi follicle stimulating hormone receptor 0.0008 0.0033 0.0021
Schistosoma mansoni neuropeptide receptor 0.0008 0.0033 0.0032
Brugia malayi hypothetical protein 0.004 0.0427 0.0487
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0049 0.0549
Onchocerca volvulus 0.0035 0.0362 0.039
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126
Echinococcus granulosus inositol monophosphatase 1 0.002 0.0179 0.0555
Schistosoma mansoni neuropeptide f receptor 76f 0.0008 0.0033 0.0032
Brugia malayi ecdysteroid receptor 0.0686 0.8475 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0126
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0018 0.0153 0.1286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0183 0.1028
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Leishmania major cathepsin L-like protease 0.002 0.0183 0.206
Toxoplasma gondii t-complex protein beta subunit 0.0015 0.0123 0.1583
Brugia malayi hypothetical protein 0.0008 0.0033 0.0021
Mycobacterium ulcerans oxidoreductase 0.0015 0.0124 0.0126
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0427 0.0467
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0124 0.1398
Brugia malayi Nuclear hormone receptor-like 1 0.0162 0.1944 0.2279
Schistosoma mansoni carbonyl reductase 0.0015 0.0124 0.0123
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0124 0.0347
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0033 0.0032
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0124 0.0136
Onchocerca volvulus 0.002 0.0183 0.0178
Brugia malayi AKH receptor 0.0008 0.0033 0.0021
Echinococcus granulosus oxidoreductase 0.0015 0.0124 0.0347
Loa Loa (eye worm) hypothetical protein 0.008 0.0931 0.1082
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0124 0.1398
Trypanosoma cruzi cruzipain precursor, putative 0.0007 0.0015 0.0169
Echinococcus multilocularis cpg binding protein 0.0036 0.0384 0.1335
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.0427 0.1496
Onchocerca volvulus 0.0017 0.0141 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0681 0.436
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0184 0.4874
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0035 0.0362 1
Toxoplasma gondii cathepsin CPL 0.002 0.0183 0.235
Mycobacterium ulcerans short-chain type oxidoreductase 0.0015 0.0124 0.0126
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0124 0.0123
Trypanosoma brucei short-chain dehydrogenase, putative 0.0015 0.0124 0.1398
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0049
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0124 0.1398
Loa Loa (eye worm) oxidoreductase 0.0015 0.0124 0.0129
Loa Loa (eye worm) oxidoreductase 0.0015 0.0124 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0124 0.1398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0033 0.0032
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0124 0.1398
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0015 0.0124 0.1398
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.0033 0.0021
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0035 0.0362 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0069 0.0068
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0072 0.0148
Onchocerca volvulus 0.0011 0.0069 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0124 0.3143
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0162 0.1944 0.2279
Schistosoma mansoni ap endonuclease 0.002 0.0184 0.0183
Brugia malayi hypothetical protein 0.0015 0.0124 0.0129
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0124 0.0129
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.001 0.0057 0.009
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0061 0.069
Echinococcus multilocularis serotonin receptor 0.0146 0.1752 0.6528
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.1538 0.18
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0183 0.1028
Schistosoma mansoni hypothetical protein 0.001 0.0057 0.0056
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0015 0.0124 0.1398
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0015 0.0124 0.1595
Trichomonas vaginalis inositol monophosphatase, putative 0.002 0.0179 0.1003
Brugia malayi G-protein coupled receptor 0.0008 0.0033 0.0021
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.0033 0.0021
Schistosoma mansoni neuropeptide receptor 0.0008 0.0033 0.0032
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.0033 0.0021
Mycobacterium ulcerans short-chain dehydrogenase 0.0015 0.0124 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0162 0.1944 0.2279
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.0427 0.0426
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0015 0.0124 0.1398
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Echinococcus granulosus GPCR family 2 0.001 0.0057 0.009
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0124 0.0123
Loa Loa (eye worm) hypothetical protein 0.0686 0.8475 1
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0015 0.0124 0.1595
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0017 0.0141 0.1813
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.01 0.01
Echinococcus granulosus Smad4 0.0009 0.0042 0.0033
Brugia malayi hypothetical protein 0.0008 0.0033 0.0021
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0092 0.1076 0.3961
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0061 0.0055
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0046 0.0049
Schistosoma mansoni hypothetical protein 0.0032 0.0329 0.0328
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0015 0.0124 0.0928
Loa Loa (eye worm) oxidoreductase 0.0015 0.0124 0.0129
Brugia malayi Pre-SET motif family protein 0.0017 0.0141 0.0149
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0124 0.0136
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0009 0.0049 0.0549
Loa Loa (eye worm) hypothetical protein 0.004 0.0427 0.0487
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0183 0.057
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0124 0.0136
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0124 0.0126

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antidepressant activity in ICEM:CET (SPF Caw) mouse assessed as antagonism of reserpine-induced hypothermia at 25 mg/kg, po administered via gavage 30 mins before reserpine challenge measured 4 hrs after reserpine treatment ChEMBL. 423198
Activity (functional) Antidepressant activity in ICEM:CET (SPF Caw) mouse assessed as antagonism of reserpine-induced blepharospasm at 25 mg/kg, po administered via gavage 30 mins before reserpine challenge measured 1 hr after reserpine treatment ChEMBL. 423198

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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