Detailed information for compound 419572

Basic information

Technical information
  • TDR Targets ID: 419572
  • Name: cyclopropylmethyl 1-(2-chloro-2-phenylethyl)- 4-[2-(4-methylphenyl)ethylamino]pyrazolo[3,4- b]pyridine-5-carboxylate
  • MW: 489.008 | Formula: C28H29ClN4O2
  • H donors: 1 H acceptors: 3 LogP: 6.34 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CCNc1c(cnc2c1cnn2CC(c1ccccc1)Cl)C(=O)OCC1CC1
  • InChi: 1S/C28H29ClN4O2/c1-19-7-9-20(10-8-19)13-14-30-26-23-16-32-33(17-25(29)22-5-3-2-4-6-22)27(23)31-15-24(26)28(34)35-18-21-11-12-21/h2-10,15-16,21,25H,11-14,17-18H2,1H3,(H,30,31)
  • InChiKey: IWQXSZVGOYWAGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • cyclopropylmethyl 1-(2-chloro-2-phenyl-ethyl)-4-[2-(p-tolyl)ethylamino]pyrazolo[3,4-b]pyridine-5-carboxylate
  • 1-(2-chloro-2-phenylethyl)-4-[2-(p-tolyl)ethylamino]-5-pyrazolo[3,4-b]pyridinecarboxylic acid cyclopropylmethyl ester
  • cyclopropylmethyl 1-(2-chloro-2-phenyl-ethyl)-4-[2-(4-methylphenyl)ethylamino]pyrazolo[3,4-b]pyridine-5-carboxylate
  • 1-(2-chloro-2-phenyl-ethyl)-4-[2-(p-tolyl)ethylamino]pyrazolo[3,4-b]pyridine-5-carboxylic acid cyclopropylmethyl ester
  • cyclopropylmethyl 1-(2-chloro-2-phenylethyl)-4-[2-(4-methylphenyl)ethylamino]pyrazolo[4,5-e]pyridine-5-carboxylate
  • cyclopropylmethyl 1-(2-chloro-2-phenyl-ethyl)-4-[2-(4-methylphenyl)ethylamino]pyrazolo[4,5-e]pyridine-5-carboxylate
  • 1-(2-chloro-2-phenylethyl)-4-[2-(4-methylphenyl)ethylamino]-5-pyrazolo[4,5-e]pyridinecarboxylic acid cyclopropylmethyl ester
  • 1-(2-chloro-2-phenyl-ethyl)-4-[2-(4-methylphenyl)ethylamino]pyrazolo[4,5-e]pyridine-5-carboxylic acid cyclopropylmethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References
Bos taurus Adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A1 receptor   326 aa 318 aa 22.3 %
Echinococcus granulosus allatostatin A receptor Adenosine A1 receptor   326 aa 304 aa 25.3 %
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 315 aa 23.8 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 296 aa 22.6 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 314 aa 21.7 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 301 aa 25.6 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 277 aa 23.8 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.3 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 331 aa 25.7 %
Echinococcus multilocularis allatostatin A receptor Adenosine A1 receptor   326 aa 306 aa 26.1 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 311 aa 21.9 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 312 aa 24.0 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 311 aa 21.9 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 307 aa 21.2 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 312 aa 22.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 326 aa 20.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor 0.0882 0.552 0.8933
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0113 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0882 0.552 0.8933
Echinococcus multilocularis dna polymerase eta 0.002 0.0046 0.0016
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0052 0.0244 0.0349
Plasmodium falciparum DNA topoisomerase 2 0.0055 0.0264 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.0098 0.0191
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0416 0.2559 0.2537
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0055 0.0264 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0015
Mycobacterium ulcerans putative regultory protein 0.0055 0.0264 0.1546
Mycobacterium ulcerans two component sensor kinase MprB 0.0055 0.0264 0.1546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Schistosoma mansoni hypothetical protein 0.0023 0.006 0.0085
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0985 0.6175 0.6164
Echinococcus granulosus cathepsin l1 0.002 0.0039 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0173 0.1014 0.1602
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0416 0.2559 0.4116
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0882 0.552 0.5506
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0882 0.552 0.7784
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0142 0.0113
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0049 0.0224 0.1387
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0047 0.0079
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0047 0.0032
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0049 0.0224 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0083 0.0446 0.0417
Trichomonas vaginalis chaperonin, putative 0.0024 0.0068 0.0096
Echinococcus multilocularis musashi 0.0173 0.1014 0.0987
Brugia malayi Pre-SET motif family protein 0.0068 0.0346 0.0515
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0049 0.0224 0.1282
Loa Loa (eye worm) hypothetical protein 0.0305 0.1853 0.2966
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0121 0.017
Loa Loa (eye worm) norepinephrine transporter 0.0305 0.1853 0.2966
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.021 0.0537
Giardia lamblia Pms1-like protein 0.0055 0.0264 1
Giardia lamblia Kinase, CMGC MAPK 0.0044 0.0195 0.6831
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0055 0.0264 0.038
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0039 0.0015
Trypanosoma brucei heat shock protein, putative 0.0055 0.0264 0.0419
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0882 0.552 0.7793
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0046 0.0025
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0466 0.2876 0.2855
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0491 0.0462
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Schistosoma mansoni nuclear receptor 0.0416 0.2559 0.3613
Onchocerca volvulus 0.0068 0.0346 0.0576
Schistosoma mansoni slit 0.0102 0.0567 0.08
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0047 0.0028
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0055 0.0264 0.1672
Brugia malayi Carboxylesterase family protein 0.0078 0.041 0.0619
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0985 0.6175 0.6164
Echinococcus multilocularis ETS transcription factor Elf 5 0.0023 0.006 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0882 0.552 0.8933
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0337 0.0476
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0049 0.0224 0.0315
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0068 0.0038
Loa Loa (eye worm) hypothetical protein 0.0052 0.0244 0.0349
Loa Loa (eye worm) hypothetical protein 0.0466 0.2876 0.4631
Loa Loa (eye worm) hypothetical protein 0.0882 0.552 0.8933
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0337 0.0476
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0039 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0142 0.0803
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0044 0.0195 0.0307
Trypanosoma brucei heat shock protein, putative 0.0055 0.0264 0.0419
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0882 0.552 0.7793
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0055 0.0264 0.1672
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0025
Brugia malayi Death domain containing protein 0.0032 0.0119 0.0145
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0365 0.0475
Loa Loa (eye worm) hypothetical protein 0.0052 0.0244 0.0349
Schistosoma mansoni hypothetical protein 0.0023 0.006 0.0085
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0347 0.0516
Onchocerca volvulus 0.0416 0.2559 0.4607
Schistosoma mansoni cell polarity protein 0.0102 0.0567 0.08
Echinococcus granulosus ETS transcription factor Elf 2 0.0023 0.006 0.0043
Onchocerca volvulus 0.0136 0.078 0.1365
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0337 0.05
Loa Loa (eye worm) nuclear receptor NHR-67 0.0416 0.2559 0.4116
Schistosoma mansoni hypothetical protein 0.0031 0.0113 0.016
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0068 0.0156
Entamoeba histolytica hypothetical protein 0.0038 0.0158 0.5286
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0049 0.0224 0.1282
Loa Loa (eye worm) hypothetical protein 0.0305 0.1853 0.2966
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0466 0.2876 0.4061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0365 0.2216
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0065
Brugia malayi hypothetical protein 0.0136 0.078 0.122
Schistosoma mansoni intermediate filament proteins 0.0173 0.1014 0.1432
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0049 0.0224 0.0354
Brugia malayi orphan nuclear receptor NR2E1 0.0416 0.2559 0.4116
Brugia malayi Nuclear hormone receptor-like 1 0.0882 0.552 0.8933
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0399 0.2452 1
Echinococcus multilocularis mitogen activated protein kinase 0.0044 0.0195 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0008
Plasmodium vivax heat shock protein 86, putative 0.0055 0.0264 0.7387
Echinococcus granulosus intermediate filament protein 0.0173 0.1014 0.1396
Mycobacterium leprae Probable lipase LipE 0.0036 0.0142 0.48
Echinococcus multilocularis mitogen activated protein kinase 3 0.0044 0.0195 0.0165
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0039 0.0015
Entamoeba histolytica DNA topoisomerase II, putative 0.0055 0.0264 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0052 0.0244 0.0215
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0068 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0337 0.0476
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0044 0.0195 0.0268
Schistosoma mansoni sodium/chloride dependent transporter 0.0305 0.1853 0.2616
Leishmania major hypothetical protein, conserved 0.0036 0.0142 0.0183
Loa Loa (eye worm) hypothetical protein 0.0173 0.1014 0.1602
Onchocerca volvulus 0.002 0.0039 0.0017
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Onchocerca volvulus 0.002 0.0039 0.0017
Loa Loa (eye worm) cytochrome P450 family protein 0.0085 0.0458 0.0696
Echinococcus multilocularis cysteine protease 0.002 0.0039 0.0009
Loa Loa (eye worm) hypothetical protein 0.0882 0.552 0.8933
Echinococcus granulosus mitogen activated protein kinase 0.0044 0.0195 0.0233
Schistosoma mansoni hypothetical protein 0.1128 0.7083 1
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0055 0.0264 1
Brugia malayi conserved hypotetical protein 0.0416 0.2559 0.4116
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0052 0.0244 0.0345
Entamoeba histolytica hypothetical protein 0.0038 0.0158 0.5286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Leishmania major cathepsin L-like protease 0.002 0.0039 0.0015
Echinococcus multilocularis cpg binding protein 0.0089 0.0483 0.0454
Echinococcus multilocularis jun protein 0.0173 0.1016 0.0989
Echinococcus granulosus acetylcholinesterase 0.0078 0.041 0.0539
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Echinococcus granulosus heat shock protein 90 0.0055 0.0264 0.0331
Loa Loa (eye worm) hypothetical protein 0.0985 0.6175 1
Brugia malayi hypoxia-induced factor 1 0.0343 0.2093 0.3357
Echinococcus multilocularis heat shock protein 90 0.0055 0.0264 0.0234
Plasmodium vivax amine transporter, putative 0.0052 0.0244 0.6776
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0068 0.1621
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0046 0.021 0.0296
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0029 0.0098 0.0191
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0052 0.0244 0.0349
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0882 0.552 0.5506
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.0264 0.038
Trypanosoma brucei heat shock protein, putative 0.0055 0.0264 0.0419
Echinococcus multilocularis dna polymerase kappa 0.002 0.0046 0.0016
Loa Loa (eye worm) TOPoisomerase family member 0.0055 0.0264 0.038
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0044 0.0195 0.0268
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0055 0.0264 0.1546
Brugia malayi nuclear receptor RXR 0.0466 0.2876 0.4631
Brugia malayi Carboxylesterase family protein 0.0078 0.041 0.0619
Loa Loa (eye worm) RNA binding protein 0.0066 0.0337 0.05
Loa Loa (eye worm) hypothetical protein 0.008 0.0426 0.0644
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0029 0.0098 0.0111
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.021 0.0293
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0882 0.552 0.7784
Brugia malayi nuclear receptor NHR-88 0.0416 0.2559 0.4116
Brugia malayi Cytochrome P450 family protein 0.0085 0.0458 0.0696
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0008
Treponema pallidum sodium- and chloride- dependent transporter 0.0305 0.1853 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0098 0.0191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0491 0.0654
Mycobacterium leprae Probable two component sensor kinase MprB 0.0055 0.0264 1
Plasmodium vivax DNA topoisomerase II, putative 0.0055 0.0264 0.7387
Schistosoma mansoni hypothetical protein 0.0038 0.0158 0.0223
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0052 0.0244 0.0304
Trypanosoma cruzi cytochrome P450, putative 0.0085 0.0458 0.0696
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0462 0.285 0.4588
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0388 0.0582
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0055 0.0264 0.0419
Loa Loa (eye worm) serotonin transporter b 0.0305 0.1853 0.2966
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0049 0.0224 0.1282
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0055 0.0264 0.1672
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0466 0.2876 0.4631
Brugia malayi small heat shock protein 0.0673 0.4192 0.6773
Brugia malayi Uncoordinated protein 44 0.0032 0.0119 0.0145
Schistosoma mansoni hypothetical protein 0.1128 0.7083 1
Brugia malayi Nuclear hormone receptor E75 0.0416 0.2559 0.4116
Brugia malayi N-terminal motif family protein 0.0177 0.1043 0.1648
Schistosoma mansoni aryl hydrocarbon receptor 0.0111 0.0619 0.0874
Brugia malayi nuclear receptor RXR 0.0416 0.2559 0.4116
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0264 0.038
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0183
Brugia malayi nuclear hormone receptor family member nhr-6 0.0416 0.2559 0.4116
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0113 0.0084
Echinococcus multilocularis aryl hydrocarbon receptor 0.0029 0.0098 0.0069
Echinococcus multilocularis acetylcholinesterase 0.0078 0.041 0.0382
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0416 0.2559 0.4116
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0044 0.0195 0.0679
Trypanosoma brucei protein kinase, putative 0.0044 0.0195 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0882 0.552 0.8933
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0015
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0052 0.0244 0.0304
Onchocerca volvulus 0.0046 0.021 0.0328
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0388 0.0582
Loa Loa (eye worm) hypothetical protein 0.0068 0.0346 0.0515
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0142 0.0183
Schistosoma mansoni pyruvate dehydrogenase 0.093 0.5827 0.8227
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0064 0.0034
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0068 0.0096
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0101 0.0115
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0044 0.0195 0.0268
Toxoplasma gondii histone lysine methyltransferase SET1 0.0162 0.0947 0.3787
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0882 0.552 0.8933
Schistosoma mansoni retinoic acid receptor RXR 0.0882 0.552 0.7793
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0113 0.0084
Echinococcus multilocularis sodium and chloride dependent glycine 0.0052 0.0244 0.0215
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0052 0.0244 0.0215
Echinococcus multilocularis nuclear receptor nhr 48 0.0416 0.2559 0.2537
Loa Loa (eye worm) hypothetical protein 0.0882 0.552 0.8933
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0018 0.003 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0142 0.3546
Toxoplasma gondii DNA topoisomerase 2, putative 0.0055 0.0264 0.0965
Trypanosoma brucei heat shock protein, putative 0.0055 0.0264 0.0419
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0052 0.0244 0.0349
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0039 0.0056
Schistosoma mansoni cytochrome P450 0.0049 0.0224 0.0316
Mycobacterium tuberculosis Conserved protein 0.0036 0.0142 0.0803
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0882 0.552 0.7793
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0064 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0065
Loa Loa (eye worm) hypothetical protein 0.0466 0.2876 0.4631
Mycobacterium tuberculosis Possible two component sensor kinase 0.0055 0.0264 0.1672
Schistosoma mansoni sodium/chloride dependent transporter 0.0052 0.0244 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Echinococcus granulosus tar DNA binding protein 0.0066 0.0337 0.0435
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0055 0.0264 0.1546
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0044 0.0195 0.0268
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0055 0.0264 1
Leishmania major cysteine peptidase A (CPA) 0.002 0.0039 0.0015
Echinococcus granulosus death domain containing protein 0.0032 0.0119 0.0126
Echinococcus multilocularis Ankyrin 0.0032 0.0121 0.0091
Loa Loa (eye worm) fibroinase 0.002 0.0039 0.0015
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0346 0.0317
Onchocerca volvulus 0.0052 0.0244 0.039
Onchocerca volvulus 0.0526 0.3255 0.5875
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0029 0.0098 0.0111
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0029 0.0098 0.0191
Loa Loa (eye worm) cysteine protease 0.002 0.0039 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0046 0.0022
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0055 0.0264 0.0705
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0055 0.0264 0.1546
Loa Loa (eye worm) hypothetical protein 0.0882 0.552 0.8933
Onchocerca volvulus 0.0036 0.0142 0.0204
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0305 0.1853 0.2966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0238 0.1427 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0055 0.0264 0.1546
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0049 0.0224 0.1387
Brugia malayi hypothetical protein 0.0052 0.0244 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0882 0.552 0.8933
Brugia malayi ecdysone receptor 0.0416 0.2559 0.4116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.1043 0.1844
Loa Loa (eye worm) hypothetical protein 0.0882 0.552 0.8933
Onchocerca volvulus 0.002 0.0039 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0046 0.0103
Brugia malayi Pre-SET motif family protein 0.0462 0.285 0.4588
Echinococcus granulosus dnaJ subfamily B 0.0807 0.5045 0.711
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Echinococcus multilocularis muscleblind protein 0.0147 0.0853 0.0825
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0064 0.0048
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0055 0.0264 0.1672
Loa Loa (eye worm) hypothetical protein 0.0046 0.021 0.0293
Brugia malayi DNA-binding protein D-ETS-3 0.0023 0.006 0.0049
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0085 0.0458 0.2828
Leishmania major cytochrome p450-like protein 0.0085 0.0458 0.0696
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0142 0.0803
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0142 0.0803
Toxoplasma gondii ABC1 family protein 0.0036 0.0142 0.0463
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0491 0.0462
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0052 0.0244 0.0345
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0055 0.0264 0.1198
Brugia malayi intermediate filament protein 0.0173 0.1014 0.1602
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0049 0.0224 0.1387
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0491 0.0654
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0882 0.552 0.7784
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0049 0.0224 0.1282
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0068 0.0062
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0097 0.0095
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0416 0.2559 0.3613
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0388 0.0582
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0039 0.0009
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0055 0.0264 0.0705
Toxoplasma gondii heat shock protein 90, putative 0.0055 0.0264 0.0965
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0491 0.0693
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0365 0.2216
Echinococcus granulosus muscleblind protein 0.0147 0.0853 0.1166
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0882 0.552 0.5506
Leishmania major cathepsin L-like protease 0.002 0.0039 0.0015
Schistosoma mansoni jun-related protein 0.0141 0.081 0.1143
Brugia malayi photoreceptor-specific nuclear receptor 0.0882 0.552 0.8933
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0049 0.0224 0.1282
Loa Loa (eye worm) hypothetical protein 0.017 0.0994 0.1569
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0346 0.0449
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0049 0.0224 0.1387
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0068 0.0062
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Loa Loa (eye worm) hypothetical protein 0.0078 0.041 0.0619
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0097 0.0067
Echinococcus multilocularis acetylcholinesterase 0.0078 0.041 0.0382
Loa Loa (eye worm) CYP4Cod1 0.0085 0.0458 0.0696
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0049 0.0224 0.1387
Loa Loa (eye worm) ctsf protein 0.002 0.0039 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0264 0.7387
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0264 0.038
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Brugia malayi hypothetical protein 0.0416 0.2559 0.4116
Echinococcus multilocularis protein C ets 2 0.0023 0.006 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Entamoeba histolytica hypothetical protein 0.0038 0.0158 0.5286
Schistosoma mansoni heat shock protein 0.0055 0.0264 0.0372
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0337 0.0308
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0047 0.0068
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0068 0.0346 0.0317
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0049 0.0224 0.1282
Leishmania major cathepsin L-like protease 0.0074 0.0388 0.0582
Loa Loa (eye worm) hypothetical protein 0.0882 0.552 0.8933
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0052 0.0244 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.021 0.0537
Brugia malayi hypothetical protein 0.0466 0.2876 0.4631
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0049 0.0224 0.1387
Mycobacterium ulcerans lipase LipD 0.0036 0.0142 0.0742
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0068 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Echinococcus granulosus heat shock protein 0.0055 0.0264 0.0331
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0049 0.0224 0.1282
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0882 0.552 0.5506
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0049 0.0224 0.1282
Onchocerca volvulus 0.0082 0.0436 0.074
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0101 0.0115
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0052 0.0244 0.0215
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Brugia malayi Nuclear hormone receptor-like 1 0.0466 0.2876 0.4631
Loa Loa (eye worm) hypothetical protein 0.0147 0.0853 0.1339
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0046 0.021 0.018
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0047 0.0024
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0365 0.1383
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0142 0.0201
Onchocerca volvulus Cathepsin L homolog 0.002 0.0039 0.0017
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0055 0.0264 0.038
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0049 0.0224 0.1282
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0365 0.0336
Mycobacterium leprae Probable two-component sensor kinase 0.0055 0.0264 1
Leishmania major DNA polymerase eta, putative 0.002 0.0046 0.0025
Loa Loa (eye worm) hypothetical protein 0.0102 0.0567 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0039 0.0008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0008 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0049 0.0224 0.1387
Loa Loa (eye worm) carboxylesterase 0.0078 0.041 0.0619
Mycobacterium tuberculosis Conserved protein 0.0036 0.0142 0.0803
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0882 0.552 0.8933
Echinococcus granulosus nuclear receptor nhr 48 0.0416 0.2559 0.3586
Brugia malayi nuclear receptor NHR-67 0.0416 0.2559 0.4116
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.0264 0.0419
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0083 0.0446 0.059
Brugia malayi tailless protein 0.0416 0.2559 0.4116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0049 0.0224 0.1282
Mycobacterium ulcerans hypothetical protein 0.0046 0.021 0.1189
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0142 0.0803
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0119 0.0145
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.0065
Mycobacterium leprae putative cytochrome p450 0.0049 0.0224 0.8294
Echinococcus multilocularis transfer RNA-Lys 0.0082 0.0436 0.0407
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0541 0.0831
Trichomonas vaginalis adenylate cyclase, putative 0.0029 0.0098 0.0191
Schistosoma mansoni hypothetical protein 0.0031 0.0113 0.016
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0052 0.0244 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0882 0.552 0.8933
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Mycobacterium ulcerans two component regulator - sensor kinase 0.0055 0.0264 0.1546
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0023 0.006 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0346 0.0489
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0049 0.0224 0.1387
Brugia malayi Probable DNA topoisomerase II 0.0055 0.0264 0.038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0008
Brugia malayi laminin alpha chain 0.0102 0.0567 0.0873
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0882 0.552 0.8933
Schistosoma mansoni ap endonuclease 0.0021 0.0047 0.0067
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.021 0.0332
Onchocerca volvulus 0.0052 0.0244 0.039
Leishmania major cathepsin L-like protease 0.0074 0.0388 0.0582
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0882 0.552 0.8933
Onchocerca volvulus 0.0173 0.1014 0.1793
Trichomonas vaginalis sensor histidine kinase, putative 0.0055 0.0264 0.0705
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0049 0.0224 0.1387
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0158 0.0128
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0055 0.0264 0.1672
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0882 0.552 0.8933
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0319 0.041
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0049 0.0224 0.1282
Plasmodium vivax polyprenol reductase, putative 0.0046 0.021 0.5685
Schistosoma mansoni coup transcription factor 0.0882 0.552 0.7793
Echinococcus granulosus GA binding protein alpha chain 0.0157 0.0915 0.1254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0882 0.552 0.8933
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0046 0.0064
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0055 0.0264 0.1546
Loa Loa (eye worm) hypothetical protein 0.0147 0.0853 0.1339
Trypanosoma brucei heat shock protein, putative 0.0055 0.0264 0.0419
Mycobacterium leprae Conserved hypothetical protein 0.0049 0.0224 0.8294
Loa Loa (eye worm) ets-domain-containing protein 0.0023 0.006 0.0049
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.041 0.0579
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0102 0.0567 0.08
Brugia malayi PAS domain containing protein 0.0111 0.0619 0.0958
Loa Loa (eye worm) hypothetical protein 0.0078 0.041 0.0619
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Leishmania major protein kinase, putative 0.0029 0.0101 0.0115
Mycobacterium ulcerans DNA gyrase subunit B 0.0055 0.0264 0.1546
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0047 0.0114
Mycobacterium ulcerans hypothetical protein 0.0036 0.0142 0.0742
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0052 0.0244 0.0345
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0047 0.0124
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0049 0.0224 0.1387
Loa Loa (eye worm) hypothetical protein 0.0305 0.1853 0.2966
Brugia malayi nuclear hormone receptor family member odr-7 0.0416 0.2559 0.4116
Loa Loa (eye worm) hypothetical protein 0.0032 0.0121 0.0147
Loa Loa (eye worm) nuclear hormone receptor 0.0416 0.2559 0.4116
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0093 0.0504 0.0772
Loa Loa (eye worm) hypothetical protein 0.0102 0.0567 0.0873
Onchocerca volvulus Bile acid receptor homolog 0.0882 0.552 1
Plasmodium falciparum transporter, putative 0.0052 0.0244 0.9173
Schistosoma mansoni hypothetical protein 0.0807 0.5045 0.7123
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0882 0.552 0.8933
Loa Loa (eye worm) CXXC zinc finger family protein 0.0084 0.0452 0.0687
Brugia malayi cytoplasmic intermediate filament protein 0.0093 0.0504 0.0772
Schistosoma mansoni DNA polymerase eta 0.002 0.0046 0.0064
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0055 0.0264 0.1546
Brugia malayi CXXC zinc finger family protein 0.0084 0.0452 0.0687
Toxoplasma gondii cytochrome p450 superfamily protein 0.0049 0.0224 0.08
Schistosoma mansoni netrin receptor unc5 0.0032 0.0119 0.0168
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0055 0.0264 0.1546
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0047 0.0739
Brugia malayi Cytochrome P450 family protein 0.0208 0.1236 0.1963
Echinococcus multilocularis 0.0049 0.0224 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0065
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0039 0.0009
Brugia malayi heat shock protein 90 0.0055 0.0264 0.038
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0049 0.0224 0.1387
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.0264 1
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0365 0.2216
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0015
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.0264 0.0419
Trypanosoma brucei heat shock protein, putative 0.0055 0.0264 0.0419
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0068 0.0102
Schistosoma mansoni lamin 0.0173 0.1014 0.1432
Brugia malayi Synaptic glycoprotein SC2 0.0046 0.021 0.0293
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0119 0.0089
Brugia malayi Fli-1 protein 0.0477 0.2949 0.475
Onchocerca volvulus 0.0173 0.1014 0.1793
Schistosoma mansoni sodium/chloride dependent transporter 0.0052 0.0247 0.0349
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0882 0.552 0.8933
Loa Loa (eye worm) hypothetical protein 0.0052 0.0244 0.0349
Brugia malayi Intermediate filament tail domain containing protein 0.0173 0.1014 0.1602
Loa Loa (eye worm) hypothetical protein 0.0055 0.0264 0.038
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0183
Schistosoma mansoni nuclear hormone receptor 0.0882 0.552 0.7793
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0055 0.0264 0.1672
Brugia malayi beta-lactamase family protein 0.0036 0.0142 0.0183
Echinococcus multilocularis heat shock protein 0.0055 0.0264 0.0234
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0195 0.049
Echinococcus multilocularis FTZ F1 alpha 0.0882 0.552 0.5506
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0882 0.552 0.8933
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.0065
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Brugia malayi transcription factor E74 isoform 0.0023 0.006 0.0049
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0113 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0142 0.0183
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0039 0.0404
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0052 0.0244 0.0345
Schistosoma mansoni nuclear receptor 0.0416 0.2559 0.3613
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0119 0.0089
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0119 0.0162
Schistosoma mansoni amine oxidase 0.0018 0.003 0.0042
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0416 0.2559 0.4607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Loa Loa (eye worm) hypoxia-induced factor 1 0.0343 0.2093 0.3357
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0039 0.0404
Trypanosoma brucei unspecified product 0.002 0.0046 0.0065
Echinococcus granulosus mitogen activated protein kinase 3 0.0044 0.0195 0.0233
Onchocerca volvulus Cathepsin L homolog 0.002 0.0039 0.0017
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0119 0.0168
Schistosoma mansoni hypothetical protein 0.0271 0.1639 0.2314
Echinococcus granulosus cpg binding protein 0.0089 0.0483 0.0642
Schistosoma mansoni hypothetical protein 0.0141 0.081 0.1143
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0039 0.0056
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.0264 1
Mycobacterium tuberculosis Conserved protein 0.0055 0.0264 0.1672
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0337 0.05
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0049 0.0224 0.1282
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0008
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0264 0.038
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0018 0.003 0.0042
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1364 0.9545
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0142 0.0803
Schistosoma mansoni hypothetical protein 0.0031 0.0113 0.016
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0344 0.2104 0.3375
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0055 0.0264 0.1672
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0047 0.0028
Giardia lamblia Synaptic glycoprotein SC2 0.0046 0.021 0.7532
Loa Loa (eye worm) fli-1 protein 0.0477 0.2949 0.475
Loa Loa (eye worm) acetylcholinesterase 1 0.0078 0.041 0.0619
Onchocerca volvulus 0.002 0.0039 0.0017
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0305 0.1853 0.2616
Echinococcus granulosus single minded 2 0.0082 0.0436 0.0576
Echinococcus granulosus geminin 0.1128 0.7083 1
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0119 0.0126
Onchocerca volvulus 0.0036 0.0142 0.0204
Echinococcus multilocularis synaptic glycoprotein sc2 0.0046 0.021 0.018
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0068 0.0054
Schistosoma mansoni amine oxidase 0.0018 0.003 0.0042
Onchocerca volvulus 0.0305 0.1853 0.3321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0491 0.0693
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0029 0.0098 0.0111
Toxoplasma gondii cathepsin CPL 0.002 0.0039 0.0039
Schistosoma mansoni elf1 0.0023 0.006 0.0085
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0055 0.0264 1
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0055 0.0264 0.0705
Brugia malayi TAR-binding protein 0.0066 0.0337 0.05
Trypanosoma brucei cytochrome P450, putative 0.0085 0.0458 0.0733
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Loa Loa (eye worm) hypothetical protein 0.0031 0.0113 0.0135
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0039 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0049 0.0224 0.1387
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0046 0.021 0.0332
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0365 0.0515
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0025
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0047 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0183
Echinococcus granulosus protein C ets 2 0.0023 0.006 0.0043
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Brugia malayi kinase, mitochondrial precursor 0.0985 0.6175 1
Brugia malayi MAP kinase sur-1 0.0044 0.0195 0.0268
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0344 0.2104 0.3375
Loa Loa (eye worm) D-ets-2 protein 0.0023 0.006 0.0049
Echinococcus multilocularis thyroid hormone receptor alpha 0.0882 0.552 0.5506
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0046 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0065
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0055 0.0264 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0142 0.0201
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0039 0.0013
Onchocerca volvulus 0.0052 0.0244 0.039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0149 0.0194
Echinococcus multilocularis serotonin transporter 0.0305 0.1853 0.1828
Leishmania major cathepsin L-like protease 0.002 0.0039 0.0015
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0101 0.0115
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0052 0.0244 0.0345
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0882 0.552 0.5506
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0142 0.0183
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0142 0.0327
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0046 0.021 0.0293
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0046 0.0025
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0047 0.0546
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0052 0.0244 0.0885
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0491 0.3037 0.4893
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.0264 0.038
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0882 0.552 0.7793
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0046 0.021 0.7599
Schistosoma mansoni ets-related 0.0477 0.2949 0.4164
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0119 0.0145
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0055 0.0264 0.1546
Brugia malayi beta-lactamase 0.0036 0.0142 0.0183
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0044 0.0195 0.0268
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0173 0.1016 0.1398
Echinococcus granulosus Ankyrin 0.0032 0.0121 0.0128
Schistosoma mansoni laminin gamma-3 chain 0.0102 0.0567 0.08
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0008
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0046 0.021 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0046 0.0025
Loa Loa (eye worm) hypothetical protein 0.0052 0.0244 0.0349
Schistosoma mansoni hypothetical protein 0.0031 0.0113 0.016
Echinococcus multilocularis sodium and chloride dependent glycine 0.0052 0.0244 0.0215
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0882 0.552 0.7784
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0039 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0049 0.0224 0.1387
Onchocerca volvulus 0.0416 0.2559 0.4607
Toxoplasma gondii heat shock protein HSP90 0.0055 0.0264 0.0965
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0416 0.2559 0.2537
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0095 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0065
Schistosoma mansoni pyruvate dehydrogenase 0.093 0.5827 0.8227
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0023 0.006 0.0085
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0416 0.2559 0.4607
Loa Loa (eye worm) hypothetical protein 0.0466 0.2876 0.4631
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0052 0.0244 0.0349
Plasmodium vivax endoplasmin, putative 0.0055 0.0264 0.7387
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0052 0.0244 0.0304
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0052 0.0244 0.0349
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Brugia malayi Steroid receptor seven-up type 2 0.0882 0.552 0.8933
Brugia malayi Cytochrome P450 family protein 0.0085 0.0458 0.0696
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0256 0.1542 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0015
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0068 0.1268
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0416 0.2559 0.3586
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0068 0.0096
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0046 0.0027
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0049 0.0224 0.1387
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0882 0.552 0.7793
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0049 0.0224 0.0315
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0046 0.0065
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0055 0.0264 0.1672
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Echinococcus granulosus dna polymerase kappa 0.002 0.0046 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0491 0.075
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0049 0.0224 0.1282
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0046 0.021 0.0742
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.0098 0.0191
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0084 0.0447 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0181 0.1069 0.1509
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0046 0.021 0.0293
Schistosoma mansoni pyruvate dehydrogenase 0.0985 0.6175 0.8719
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0113 0.0118
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0052 0.0244 0.0345
Brugia malayi hypothetical protein 0.0416 0.2559 0.4116
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.021 0.0537
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0055 0.0264 0.0426
Loa Loa (eye worm) steroid hormone receptor 0.0882 0.552 0.8933
Trypanosoma brucei heat shock protein, putative 0.0055 0.0264 0.0419
Echinococcus granulosus ETS transcription factor Elf 1 0.0023 0.006 0.0043
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0264 0.0705
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0025
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0055 0.0264 0.0419
Brugia malayi Muscleblind-like protein 0.0147 0.0853 0.1339
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0065
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0416 0.2559 0.2537
Schistosoma mansoni RAR-like nuclear receptor 0.0882 0.552 0.7793
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0416 0.2559 0.2537
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0113 0.0135
Loa Loa (eye worm) hypothetical protein 0.0673 0.4192 0.6773
Schistosoma mansoni steroid hormone receptor ad4bp 0.0882 0.552 0.7793
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0055 0.0264 0.0426
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0046 0.0025
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0244 0.6776
Brugia malayi bZIP transcription factor family protein 0.0173 0.1016 0.1604
Loa Loa (eye worm) hypothetical protein 0.0371 0.2276 0.3654
Echinococcus granulosus FTZ F1 alpha 0.0882 0.552 0.7784
Trypanosoma cruzi DNA topoisomerase II, putative 0.0055 0.0264 0.038
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0049 0.0224 0.1282
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0142 0.0327
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0008
Brugia malayi EGF-like domain containing protein 0.0102 0.0567 0.0873
Mycobacterium leprae Possible regulatory protein 0.0029 0.0098 0.2923
Entamoeba histolytica hypothetical protein 0.0046 0.021 0.7599
Trypanosoma cruzi Heat shock protein 83, putative 0.0055 0.0264 0.038
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0164 0.0957 0.093
Schistosoma mansoni cpg binding protein 0.0089 0.0483 0.0681
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0023 0.006 0.003
Schistosoma mansoni cpg binding protein 0.0084 0.0452 0.0638
Echinococcus granulosus slit 2 protein 0.0102 0.0567 0.0761
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0046 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0142 0.0327
Echinococcus granulosus ETS transcription factor Elf 2 0.0023 0.006 0.0043
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0113 0.0118
Trypanosoma cruzi DNA topoisomerase II, putative 0.0055 0.0264 0.038
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0337 0.0476
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0047 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0541 0.0831
Loa Loa (eye worm) cytochrome P450 0.0049 0.0224 0.0315
Echinococcus granulosus dna polymerase eta 0.002 0.0046 0.0022
Loa Loa (eye worm) DR-78 0.0416 0.2559 0.4116
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0264 0.0705
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0388 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0882 0.552 0.8933
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.021 0.0537
Echinococcus granulosus ETS domain containing protein Elk 1 0.0023 0.006 0.0043
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.021 0.5685
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0055 0.0264 0.0965
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0119 0.0126
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0365 0.2398
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0046 0.0103
Mycobacterium ulcerans putative regulatory protein 0.0082 0.0436 0.2686
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.0264 1
Brugia malayi cytochrome P450 0.0049 0.0224 0.0315
Echinococcus granulosus lamin 0.0173 0.1014 0.1396
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0029 0.0098 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0098 0.0191
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0047 0.035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0541 0.0831
Trichomonas vaginalis guanylate cyclase, putative 0.0029 0.0098 0.0191
Leishmania major cytochrome p450-like protein 0.0049 0.0224 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0065
Onchocerca volvulus Cathepsin F homolog 0.002 0.0039 0.0017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0882 0.552 0.5506
Loa Loa (eye worm) hypothetical protein 0.0102 0.0567 0.0873
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0142 0.0222
Schistosoma mansoni gabp alpha 0.0157 0.0915 0.1291
Echinococcus granulosus thyroid hormone receptor alpha 0.0416 0.2559 0.3586
Echinococcus granulosus Nuclear hormone receptor HR96 0.0416 0.2559 0.3586
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0046 0.0272
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0046 0.0111
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0015
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0049 0.0224 0.1282
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0055 0.0264 0.0705
Echinococcus multilocularis pikachurin 0.0102 0.0567 0.0538
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.021 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Brugia malayi hypothetical protein 0.0466 0.2876 0.4631
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0142 0.48
Onchocerca volvulus 0.002 0.0039 0.0017
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0882 0.552 0.7793
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0365 0.0545
Brugia malayi hypothetical protein 0.0371 0.2276 0.3654
Echinococcus multilocularis lamin dm0 0.0173 0.1014 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0052 0.0244 0.0304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0055 0.0264 0.038
Schistosoma mansoni endoplasmin 0.0055 0.0264 0.0372
Echinococcus granulosus sodium and chloride dependent glycine 0.0052 0.0244 0.0304
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0049 0.0224 0.1387
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Echinococcus granulosus acetylcholinesterase 0.0078 0.041 0.0539
Plasmodium falciparum DNA gyrase subunit B 0.0055 0.0264 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0055 0.0264 0.1672
Schistosoma mansoni hypothetical protein 0.0067 0.0343 0.0484
Loa Loa (eye worm) hypothetical protein 0.0046 0.021 0.0293
Brugia malayi Ets-domain containing protein 0.0157 0.0915 0.144
Toxoplasma gondii hypothetical protein 0.0052 0.0244 0.0885
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0416 0.2559 0.2537
Schistosoma mansoni ap endonuclease 0.0021 0.0047 0.0067
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0102 0.0567 0.0873
Echinococcus multilocularis ewsr:fli fusion protein type 0.0023 0.006 0.003
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0023 0.006 0.0049
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0097 0.0109
Plasmodium falciparum endoplasmin, putative 0.0055 0.0264 1
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Echinococcus multilocularis ecdysone induced protein 78C 0.0882 0.552 0.5506
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0055 0.0264 0.1672
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0046 0.0064
Echinococcus granulosus ETS transcription factor Elf 5 0.0023 0.006 0.0043
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0052 0.0244 0.0885
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0491 0.075
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0039 0.0404
Plasmodium falciparum heat shock protein 90 0.0055 0.0264 1
Trichomonas vaginalis guanylate cyclase, putative 0.0029 0.0098 0.0191
Echinococcus granulosus GPCR family 2 0.0031 0.0113 0.0118
Brugia malayi hypothetical protein 0.0038 0.0158 0.0208
Echinococcus multilocularis dnaJ subfamily B 0.0807 0.5045 0.503
Echinococcus multilocularis neurogenic locus notch protein 0.0102 0.0567 0.0538
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0049 0.0224 0.1282
Loa Loa (eye worm) hypothetical protein 0.0052 0.0244 0.0349
Echinococcus multilocularis ETS transcription factor Elf 2 0.0023 0.006 0.003
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0046 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0068 0.0346 0.0489
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0046 0.021 0.0537
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0466 0.2876 0.4036
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0055 0.0264 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0008
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0044 0.0195 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0466 0.2876 0.4631
Brugia malayi Protein kinase domain containing protein 0.0032 0.0121 0.0149
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0047 0.0028
Echinococcus granulosus Nuclear hormone receptor HR96 0.0416 0.2559 0.3586
Loa Loa (eye worm) hypothetical protein 0.0098 0.0541 0.0831
Schistosoma mansoni thyroid hormone receptor 0.0882 0.552 0.7793
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0049 0.0224 0.1387
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0173 0.1014 0.1602
Loa Loa (eye worm) hypothetical protein 0.0466 0.2876 0.4631
Loa Loa (eye worm) hypothetical protein 0.0055 0.0264 0.038
Leishmania major protein kinase, putative 0.0033 0.0125 0.0155
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0055 0.0264 0.0426
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0046 0.021 0.0255
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0068 0.1024
Loa Loa (eye worm) heat shock protein 90 0.0055 0.0264 0.038
Trichomonas vaginalis receptor histidine kinase, putative 0.0055 0.0264 0.0705
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0068 0.1198
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0049 0.0224 0.1387
Leishmania major cathepsin L-like protease 0.002 0.0039 0.0015
Onchocerca volvulus 0.0084 0.0452 0.0769
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Schistosoma mansoni nuclear hormone receptor 0.0416 0.2559 0.3613
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0029 0.0098 0.0097
Echinococcus multilocularis ets variant gene 4 0.0023 0.006 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0346 0.0489
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Echinococcus multilocularis GA binding protein alpha chain 0.0157 0.0915 0.0887
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0142 0.0742
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0985 0.6175 0.8713
Leishmania major DNA topoisomerase ii 0.0055 0.0264 0.038
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0044 0.0195 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0882 0.552 0.8933
Echinococcus granulosus neurogenic locus notch protein 0.0102 0.0567 0.0761
Echinococcus granulosus ewsr:fli fusion protein type 0.0023 0.006 0.0043
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0046 0.021 0.0537
Schistosoma mansoni ets-related 0.0023 0.006 0.0085
Schistosoma mansoni zinc finger protein 0.0416 0.2559 0.3613
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0052 0.0244 0.5146
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0985 0.6175 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0158 0.0223
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0055 0.0264 0.0234
Leishmania major DNA polymerase kappa, putative 0.002 0.0046 0.0025
Echinococcus granulosus carboxylesterase 5A 0.0078 0.041 0.0539
Loa Loa (eye worm) hypothetical protein 0.0416 0.2559 0.4116
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0195 0.049
Schistosoma mansoni single-minded 0.0111 0.0619 0.0874
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0049 0.0224 0.1282
Schistosoma mansoni sodium-dependent amino acid transporter 0.0052 0.0244 0.0345
Leishmania major cytochrome p450-like protein 0.0049 0.0224 0.0315
Brugia malayi Nuclear hormone receptor E75 0.0416 0.2559 0.4116
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0055 0.0264 0.1198
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0052 0.0244 0.0345
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0101 0.0115
Schistosoma mansoni nuclear receptor nhr-48 0.0416 0.2559 0.3613
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0049 0.0224 0.1282
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.021 0.0293
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0388 0.062
Brugia malayi nuclear receptor NHR-88 0.0882 0.552 0.8933
Loa Loa (eye worm) beta-lactamase 0.0036 0.0142 0.0183
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0055 0.0264 0.0419
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0008
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0047 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0882 0.552 0.8933
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0111
Onchocerca volvulus 0.002 0.0039 0.0017
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0068 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0491 0.0693
Toxoplasma gondii exonuclease III APE 0.0021 0.0047 0.0071
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0068 0.0346 0.1306
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.021 0.7696
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0046 0.021 0.0742
Onchocerca volvulus 0.0036 0.0142 0.0204
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0025
Loa Loa (eye worm) hypothetical protein 0.0134 0.077 0.1204
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0049 0.0224 0.1387
Loa Loa (eye worm) hypothetical protein 0.0052 0.0244 0.0349
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0049 0.0224 0.1387
Loa Loa (eye worm) solute carrier family 6 member 4 0.0305 0.1853 0.2966
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0046 0.021 0.7599
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0416 0.2559 0.3613
Loa Loa (eye worm) hypothetical protein 0.0882 0.552 0.8933
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0195 0.0275
Onchocerca volvulus Protein ultraspiracle homolog 0.0882 0.552 1
Schistosoma mansoni cpg binding protein 0.0089 0.0483 0.0681
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0882 0.552 0.7784
Trichomonas vaginalis DNA topoisomerase II, putative 0.0055 0.0264 0.0705
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0049 0.0224 0.0315
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0049 0.0224 0.1387
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0046 0.021 0.7599
Leishmania major cathepsin L-like protease 0.0074 0.0388 0.0582
Brugia malayi Ets-domain containing protein 0.0023 0.006 0.0049
Schistosoma mansoni thyroid hormone receptor 0.0882 0.552 0.7793
Brugia malayi bHLH-PAS transcription factor 0.0082 0.0436 0.0661
Schistosoma mansoni heat shock protein 0.0055 0.0264 0.0372
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0068 0.0062
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0068 0.0062
Echinococcus granulosus lamin dm0 0.0173 0.1014 0.1396
Schistosoma mansoni hypothetical protein 0.0049 0.0224 0.0316
Leishmania major hypothetical protein, conserved 0.0055 0.0264 0.038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0064 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0882 0.552 0.8933
Echinococcus granulosus pikachurin 0.0102 0.0567 0.0761
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0039 0.0009
Chlamydia trachomatis DNA gyrase subunit B 0.0055 0.0264 0.561
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0142 0.0742
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0882 0.552 0.7784
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0882 0.552 1
Brugia malayi Endoplasmin precursor 0.0055 0.0264 0.038
Echinococcus multilocularis cysteine protease 0.002 0.0039 0.0009
Trypanosoma brucei DNA topoisomerase ii 0.0055 0.0264 0.0419
Mycobacterium tuberculosis Probable two component sensor kinase 0.0055 0.0264 0.1672
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0052 0.0244 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0039 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0195 0.049
Leishmania major developmentally regulated phosphoprotein-like protein 0.0985 0.6175 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0049 0.0224 0.1282
Brugia malayi RNA binding protein 0.0066 0.0337 0.05
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0046 0.021 0.0742
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0142 0.0803
Brugia malayi Cytochrome P450 family protein 0.0049 0.0224 0.0315
Trypanosoma brucei Heat shock protein 83, putative 0.0055 0.0264 0.0419
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0344 0.2104 0.3401
Loa Loa (eye worm) hypothetical protein 0.0168 0.0986 0.1555
Trichomonas vaginalis endoplasmin, putative 0.0055 0.0264 0.0705
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0064 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0525 0.3253 1
Brugia malayi beta-lactamase family protein 0.0036 0.0142 0.0183
Loa Loa (eye worm) endoplasmin 0.0055 0.0264 0.038
Echinococcus granulosus synaptic glycoprotein sc2 0.0046 0.021 0.0255
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0365 0.0515
Brugia malayi Ets-domain containing protein 0.0157 0.0915 0.144
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0882 0.552 0.7784
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0055 0.0264 0.0705
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0039 0.0015
Loa Loa (eye worm) hypothetical protein 0.0052 0.0244 0.0349
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0343 0.0509
Loa Loa (eye worm) hypothetical protein 0.008 0.0426 0.0644
Trypanosoma brucei heat shock protein, putative 0.0055 0.0264 0.0419
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0142 0.0327
Echinococcus granulosus ecdysone induced protein 78C 0.0882 0.552 0.7784
Brugia malayi ecdysteroid receptor 0.0882 0.552 0.8933
Echinococcus multilocularis geminin 0.1128 0.7083 0.7074
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0098 0.0191
Echinococcus granulosus nuclear factor of activated T cells 5 0.0164 0.0957 0.1315
Leishmania major mitochondrial DNA topoisomerase II 0.0055 0.0264 0.038
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0142 0.0159
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0195 0.049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0416 0.2559 0.3586
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.021 0.0293
Echinococcus multilocularis ETS transcription factor Elf 1 0.0023 0.006 0.003
Echinococcus granulosus jun protein 0.0173 0.1016 0.1398
Loa Loa (eye worm) hypothetical protein 0.0882 0.552 0.8933
Loa Loa (eye worm) hypothetical protein 0.0067 0.0343 0.0509
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0157 0.0915 0.144
Mycobacterium tuberculosis Conserved protein 0.0036 0.0142 0.0803
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0049
Trypanosoma cruzi cytochrome P450, putative 0.0085 0.0458 0.0696
Plasmodium vivax DNA gyrase subunit B, putative 0.0055 0.0264 0.7387
Echinococcus multilocularis GPCR, family 2 0.0031 0.0113 0.0084
Trichomonas vaginalis esterase, putative 0.0036 0.0142 0.0327
Loa Loa (eye worm) hypothetical protein 0.0032 0.0119 0.0145
Loa Loa (eye worm) abnormal epIthelia family member 0.0102 0.0567 0.0873
Brugia malayi nuclear hormone receptor 0.0416 0.2559 0.4116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0158 0.0181
Schistosoma mansoni endoplasmin 0.0055 0.0264 0.0372
Loa Loa (eye worm) hypothetical protein 0.0046 0.021 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0882 0.552 0.8933
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0256 0.1542 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0287 0.0418
Echinococcus granulosus sodium and chloride dependent glycine 0.0052 0.0244 0.0304
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0055 0.0264 0.1672
Loa Loa (eye worm) hypothetical protein 0.0466 0.2876 0.4631
Echinococcus multilocularis ETS transcription factor Elf 2 0.0023 0.006 0.003
Brugia malayi steroid hormone receptor 0.0882 0.552 0.8933
Echinococcus multilocularis lamin 0.0173 0.1014 0.0987
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0882 0.552 0.8933
Echinococcus multilocularis slit 2 protein 0.0102 0.0567 0.0538
Loa Loa (eye worm) cytochrome P450 family protein 0.0208 0.1236 0.1963
Loa Loa (eye worm) hypothetical protein 0.0083 0.0446 0.0677
Plasmodium vivax SET domain protein, putative 0.0068 0.0346 1
Schistosoma mansoni nuclear hormone receptor 0.0416 0.2559 0.3613
Plasmodium falciparum amino acid transporter, putative 0.0052 0.0244 0.9173
Plasmodium vivax vivapain-2 0.002 0.0039 0.0298
Toxoplasma gondii hypothetical protein 0.0052 0.0244 0.0885
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0142 0.0183
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.021 0.0537
Schistosoma mansoni ets 0.0023 0.006 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0346 0.0489
Brugia malayi laminin-like protein K08C7.3 precursor 0.0102 0.0567 0.0873
Onchocerca volvulus 0.0029 0.0098 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0025
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0466 0.2876 0.4061
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0344 0.2104 0.8562
Schistosoma mansoni DNA topoisomerase II 0.0055 0.0264 0.0372
Onchocerca volvulus 0.0882 0.552 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0023 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0177 0.1043 0.1648
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0065
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0047 0.0028
Leishmania major cathepsin L-like protease 0.002 0.0039 0.0015
Trypanosoma brucei developmentally regulated phosphoprotein 0.0985 0.6175 1
Echinococcus granulosus cytochrome P450 2K1 0.0049 0.0224 0.0275
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0046 0.0016
Echinococcus multilocularis carboxylesterase 5A 0.0078 0.041 0.0382
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0337 0.05
Echinococcus granulosus aryl hydrocarbon receptor 0.0029 0.0098 0.0097
Mycobacterium ulcerans beta-lactamase 0.0036 0.0142 0.0742
Entamoeba histolytica hypothetical protein 0.0038 0.0158 0.5286
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0142 0.0803
Brugia malayi follicle stimulating hormone receptor 0.0491 0.3037 0.4893
Leishmania major heat shock protein 83-1 0.0055 0.0264 0.038
Loa Loa (eye worm) cytochrome P450 family protein 0.0085 0.0458 0.0696
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0055 0.0264 0.0331
Plasmodium vivax vivapain-2 0.002 0.0039 0.0298
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0029 0.0098 0.0069
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0049
Chlamydia trachomatis DNA gyrase subunit B 0.0055 0.0264 0.561
Schistosoma mansoni hypothetical protein 0.0032 0.0119 0.0168
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0055 0.0264 0.0965
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0049 0.0224 0.1282
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0046 0.021 0.0296
Schistosoma mansoni lamin 0.0173 0.1014 0.1432
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0337 0.0476
Echinococcus granulosus serotonin transporter 0.0305 0.1853 0.2585
Trichomonas vaginalis receptor histidine kinase, putative 0.0055 0.0264 0.0705
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0853 0.0825
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0142 0.0327
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.0098 0.0191
Plasmodium falciparum polyprenol reductase, putative 0.0046 0.021 0.7696
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0055 0.0264 0.038
Onchocerca volvulus 0.002 0.0039 0.0017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0173 0.1016 0.0989
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0055 0.0264 0.038

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 4 % Displacement of [3HCGS21680 from adenosine A2A receptor in bovine cerebral cortical membranes at 10 uM ChEMBL. 16279775
Inhibition (binding) = 4 % Displacement of [3HCGS21680 from adenosine A2A receptor in bovine cerebral cortical membranes at 10 uM ChEMBL. 16279775
Ki (binding) Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 16279775
Ki (binding) = -7.2 Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells ChEMBL. 16279775
Ki (binding) 0 Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 16279775
Ki (binding) = 63 nM Displacement of [3H]DPCPX from adenosine A1 receptor in bovine cerebral cortical membranes ChEMBL. 16279775
Ki (binding) = 63 nM Displacement of [3H]DPCPX from adenosine A1 receptor in bovine cerebral cortical membranes ChEMBL. 16279775
Log Ki (binding) = 7.2 Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells ChEMBL. 16279775

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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