pI: 6.4581 |
Length (AA): 160 |
MW (Da): 17080 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 160 | 4k9d (A) | 180 | 339 | 98.00 | 0 | 1 | 2.0744 | -0.01 |
1 | 160 | 5c7i (O) | 279 | 438 | 78.00 | 0 | 1 | 1.8724 | 0.01 |
10 | 47 | 3ls0 (A) | 71 | 108 | 37.00 | 0.82 | 0.1 | 0.6879 | -0.77 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126628)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G42970 | glyceraldehyde-3-phosphate dehydrogenase B |
Arabidopsis thaliana | AT3G04120 | glyceraldehyde-3-phosphate dehydrogenase C subunit 1 |
Arabidopsis thaliana | AT1G79530 | glyceraldehyde-3-phosphate dehydrogenase GAPCP1 |
Arabidopsis thaliana | AT3G26650 | glyceraldehyde-3-phosphate dehydrogenase A subunit |
Arabidopsis thaliana | AT1G16300 | glyceraldehyde 3-phosphate dehydrogenase |
Babesia bovis | BBOV_II002540 | glyceraldehyde-3-phosphate dehydrogenase protein |
Brugia malayi | Bm1_41940 | Glyceraldehyde 3-phosphate dehydrogenase |
Candida albicans | CaO19.6814 | glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen |
Candida albicans | CaO19.14106 | glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen |
Caenorhabditis elegans | CELE_K10B3.8 | Protein GPD-2 |
Caenorhabditis elegans | CELE_T09F3.3 | Protein GPD-1 |
Caenorhabditis elegans | CELE_K10B3.7 | Protein GPD-3 |
Caenorhabditis elegans | CELE_F33H1.2 | Protein GPD-4 |
Cryptosporidium hominis | Chro.60434 | glyceraldehyde-3-phosphate dehydrogenase |
Cryptosporidium parvum | cgd6_3790 | glyceraldehyde 3-phosphate dehydrogenase |
Chlamydia trachomatis | CT_505 | glyceraldehyde-3-phosphate dehydrogenase |
Dictyostelium discoideum | DDB_G0275153 | NAD+-dependent glyceraldehyde phosphate dehydrogenase |
Drosophila melanogaster | Dmel_CG8893 | Glyceraldehyde 3 phosphate dehydrogenase 2 |
Drosophila melanogaster | Dmel_CG9010 | CG9010 gene product from transcript CG9010-RA |
Drosophila melanogaster | Dmel_CG12055 | Glyceraldehyde 3 phosphate dehydrogenase 1 |
Escherichia coli | b2927 | D-erythrose 4-phosphate dehydrogenase |
Escherichia coli | b1779 | glyceraldehyde-3-phosphate dehydrogenase A |
Echinococcus granulosus | EgrG_000254600 | glyceraldehyde 3 phosphate dehydrogenase |
Echinococcus granulosus | EgrG_001101100 | glyceraldehyde 3 phosphate dehydrogenase |
Echinococcus granulosus | EgrG_000429600 | glyceraldehyde 3 phosphate dehydrogenase |
Entamoeba histolytica | EHI_008200 | glyceraldehyde-3-phosphate dehydrogenase, putative |
Entamoeba histolytica | EHI_187020 | glyceraldehyde-3-phosphate dehydrogenase, putative |
Entamoeba histolytica | EHI_167320 | glyceraldehyde-3-phosphate dehydrogenase, putative |
Echinococcus multilocularis | EmuJ_001101100 | glyceraldehyde 3 phosphate dehydrogenase |
Echinococcus multilocularis | EmuJ_000254600 | glyceraldehyde 3 phosphate dehydrogenase |
Echinococcus multilocularis | EmuJ_000429600 | glyceraldehyde 3 phosphate dehydrogenase |
Giardia lamblia | GL50803_6687 | Glyceraldehyde 3-phosphate dehydrogenase |
Homo sapiens | ENSG00000105679 | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic |
Homo sapiens | ENSG00000111640 | glyceraldehyde-3-phosphate dehydrogenase |
Leishmania braziliensis | LbrM.30.2950 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Leishmania donovani | LdBPK_362480.1 | glyceraldehyde 3-phosphate dehydrogenase, cytosolic |
Leishmania donovani | LdBPK_303000.1 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Leishmania infantum | LinJ.30.3000 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Leishmania infantum | LinJ.30.2990 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Leishmania infantum | LinJ.36.2480 | glyceraldehyde 3-phosphate dehydrogenase, cytosolic |
Leishmania major | LmjF.30.2980 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Leishmania major | LmjF.30.2970 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Leishmania mexicana | LmxM.29.2980 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Leishmania mexicana | LmxM.36.2350 | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative |
Loa Loa (eye worm) | LOAG_12990 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12084 | glyceraldehyde 3-phosphate dehydrogenase |
Loa Loa (eye worm) | LOAG_06426 | glyceraldehyde-3-phosphate dehydrogenase |
Loa Loa (eye worm) | LOAG_16104 | glyceraldehyde 3-phosphate dehydrogenase |
Loa Loa (eye worm) | LOAG_12052 | glyceraldehyde-3-phosphate dehydrogenase |
Mycobacterium leprae | ML0570 | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) |
Mus musculus | 100042025 | predicted gene, 20899 |
Mus musculus | ENSMUSG00000061099 | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic |
Mus musculus | ENSMUSG00000057666 | glyceraldehyde-3-phosphate dehydrogenase |
Mycobacterium tuberculosis | Rv1436 | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) |
Mycobacterium ulcerans | MUL_1828 | glyceraldehyde 3-phosphate dehydrogenase Gap |
Neospora caninum | NCLIV_041940 | Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), related |
Neospora caninum | NCLIV_037190 | glyceraldehyde-3-phosphate dehydrogenase, putative |
Oryza sativa | 4329892 | Os02g0601300 |
Oryza sativa | 4331495 | Os03g0129300 |
Oryza sativa | 4344564 | Os08g0126300 |
Oryza sativa | 4341782 | Os06g0666600 |
Oryza sativa | 4336044 | Os04g0459500 |
Oryza sativa | 4328446 | Os02g0171100 |
Oryza sativa | 4336216 | Os04g0486600 |
Plasmodium berghei | PBANKA_1326400 | glyceraldehyde-3-phosphate dehydrogenase |
Plasmodium falciparum | PF3D7_1462800 | glyceraldehyde-3-phosphate dehydrogenase |
Plasmodium knowlesi | PKNH_1218700 | glyceraldehyde-3-phosphate dehydrogenase, putative |
Plasmodium vivax | PVX_117322 | glyceraldehyde-3-phosphate dehydrogenase, putative |
Plasmodium yoelii | PY03280 | glyceraldehyde-3-phosphate dehydrogenase |
Saccharomyces cerevisiae | YGR192C | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 |
Saccharomyces cerevisiae | YJL052W | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 |
Saccharomyces cerevisiae | YJR009C | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 |
Schistosoma japonicum | Sjp_0025800 | ko:K00134 glyceraldehyde 3-phosphate dehydrogenase [EC1.2.1.12], putative |
Schistosoma mansoni | Smp_056970.2 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
Schistosoma mansoni | Smp_056970.4 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
Schistosoma mansoni | Smp_056970.3 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
Schistosoma mansoni | Smp_056970.1 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
Schmidtea mediterranea | mk4.004748.00 | Glyceraldehyde-3-phosphate dehydrogenase |
Schmidtea mediterranea | mk4.002051.00 | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific |
Schmidtea mediterranea | mk4.001021.01 | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific |
Schmidtea mediterranea | mk4.000484.08 | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific |
Schmidtea mediterranea | mk4.000238.07 | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific |
Schmidtea mediterranea | mk4.000238.04 | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific |
Trypanosoma brucei gambiense | Tbg972.10.8410 | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative |
Trypanosoma brucei gambiense | Tbg972.6.4110 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Trypanosoma brucei gambiense | Tbg972.6.4080 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Trypanosoma brucei | Tb927.10.6880 | glyceraldehyde 3-phosphate dehydrogenase, cytosolic |
Trypanosoma brucei | Tb927.6.4280 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Trypanosoma brucei | Tb927.6.4300 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Trypanosoma congolense | TcIL3000_10_5910 | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative |
Trypanosoma congolense | TcIL3000_0_36950 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Trypanosoma congolense | TcIL3000_0_05050 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal |
Trypanosoma cruzi | TcCLB.506943.60 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.509065.70 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.506943.50 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.509065.60 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.510105.230 | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative |
Trypanosoma cruzi | TcCLB.510187.60 | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative |
Trypanosoma cruzi | TcCLB.509717.80 | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative |
Toxoplasma gondii | TGME49_289690 | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 |
Toxoplasma gondii | TGME49_269190 | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 |
Treponema pallidum | TP0844 | glyceraldehyde 3-phosphate dehydrogenase (gap) |
Theileria parva | TP04_0383 | glyceraldehyde-3-phosphate dehydrogenase, putative |
Theileria parva | TP02_0858 | glyceraldehyde-3-phosphate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_366380 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_412780 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_146910 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_475220 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_347410 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_476100 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_193800 | glyceraldehyde 3-phosphate dehydrogenase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0298 | glyceraldehyde-3-phosphate dehydrogenase, GapA |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.6880 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6880 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6880 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.6880 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.6.4280 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4280 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4280 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.4280 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1779 | Escherichia coli | essential | goodall |
b2927 | Escherichia coli | non-essential | goodall |
CELE_T09F3.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T09F3.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K10B3.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K10B3.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K10B3.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K10B3.7 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F33H1.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F33H1.2 | Caenorhabditis elegans | larval arrest | wormbase |
PBANKA_1326400 | Plasmodium berghei | Essential | plasmo |
TGME49_289690 | Toxoplasma gondii | Probably essential | sidik |
TGME49_269190 | Toxoplasma gondii | Probably essential | sidik |
TGME49_289690 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_269190 | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | Compounds | References |
Oryctolagus cuniculus | Glyceraldehyde-3-phosphate dehydrogenase | Compounds | References |
Leishmania mexicana | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | Compounds | References |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | Compounds | References |
Homo sapiens | glyceraldehyde-3-phosphate dehydrogenase | Compounds | References |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | Compounds | References |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | Compounds | References |