Detailed information for compound 1212047

Basic information

Technical information
  • TDR Targets ID: 1212047
  • Name: (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroeth yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4 -one
  • MW: 275.282 | Formula: C13H14FN5O
  • H donors: 3 H acceptors: 3 LogP: 0.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCC[C@H]1CNC(=O)c2c1[nH]c(c2)c1ccnc(n1)N
  • InChi: 1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19)/t7-/m0/s1
  • InChiKey: LCBAQTCTQXHTJG-ZETCQYMHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (7S)-2-(2-amino-4-pyrimidinyl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 11 Starlite/ChEMBL References
Homo sapiens aurora kinase A Starlite/ChEMBL References
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 9 Starlite/ChEMBL References
Homo sapiens NIMA-related kinase 6 Starlite/ChEMBL References
Homo sapiens pyruvate dehydrogenase kinase, isozyme 1 Starlite/ChEMBL References
Homo sapiens NIM1 serine/threonine protein kinase Starlite/ChEMBL References
Homo sapiens cell division cycle 7 Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL References
Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 Starlite/ChEMBL References
Homo sapiens insulin receptor Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 4 Starlite/ChEMBL References
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens ret proto-oncogene Starlite/ChEMBL References
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens STE20-like kinase Starlite/ChEMBL References
Homo sapiens fms-related tyrosine kinase 4 Starlite/ChEMBL References
Homo sapiens serine/threonine protein kinase 26 Starlite/ChEMBL References
Homo sapiens protein kinase C, beta Starlite/ChEMBL References
Homo sapiens checkpoint kinase 1 Starlite/ChEMBL References
Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon Starlite/ChEMBL References
Homo sapiens anaplastic lymphoma receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References
Homo sapiens fibroblast growth factor receptor 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens High affinity immunoglobulin gamma Fc receptor I Starlite/ChEMBL References
Homo sapiens polo-like kinase 1 Starlite/ChEMBL References
Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Starlite/ChEMBL References
Homo sapiens TAO kinase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum protein kinase, putative Get druggable targets OG5_127277 All targets in OG5_127277
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum expressed protein Get druggable targets OG5_132867 All targets in OG5_132867
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) NEK/NEK6 protein kinase Get druggable targets OG5_131134 All targets in OG5_131134
Onchocerca volvulus Get druggable targets OG5_132867 All targets in OG5_132867
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Get druggable targets OG5_130531 All targets in OG5_130531
Loa Loa (eye worm) STE/STE20/SLK protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_127277 All targets in OG5_127277
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase NIM1, putative Get druggable targets OG5_132867 All targets in OG5_132867
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08837 serine/threonine kinase 10, putative Get druggable targets OG5_130670 All targets in OG5_130670
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132867 All targets in OG5_132867
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus serine threonine protein kinase Get druggable targets OG5_127277 All targets in OG5_127277
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania infantum developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Serine/threonine-protein kinase SULU Get druggable targets OG5_129521 All targets in OG5_129521
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax serine/threonine-specific protein kinase, putative Get druggable targets OG5_127277 All targets in OG5_127277
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128769 All targets in OG5_128769
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis STE family protein kinase Get druggable targets OG5_127277 All targets in OG5_127277
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. pombe SPAC644.11c predicted pyruvate dehydrogenase kinase Get druggable targets OG5_127409 All targets in OG5_127409
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_127277 All targets in OG5_127277
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Chlamydia trachomatis serine/threonine protein kinase Get druggable targets OG5_131134 All targets in OG5_131134
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) STE/STE20/YSK protein kinase Get druggable targets OG5_127277 All targets in OG5_127277
Schistosoma japonicum ko:K08857 NIMA (never in mitosis gene a)-related kinase, putative Get druggable targets OG5_131134 All targets in OG5_131134
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis serine:threonine protein kinase NIM1 Get druggable targets OG5_132867 All targets in OG5_132867
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130454 All targets in OG5_130454
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine:threonine protein kinase TAO1 Get druggable targets OG5_129521 All targets in OG5_129521
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase Nek6, putative Get druggable targets OG5_131134 All targets in OG5_131134
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial precursor, putative Get druggable targets OG5_127409 All targets in OG5_127409
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132867 All targets in OG5_132867
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_128769 All targets in OG5_128769
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis STE family protein kinase Get druggable targets OG5_127277 All targets in OG5_127277
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase Get druggable targets OG5_127409 All targets in OG5_127409
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_132247 All targets in OG5_132247
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04429 thousand and one amino acid protein kinase, putative Get druggable targets OG5_129521 All targets in OG5_129521
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Get druggable targets OG5_130531 All targets in OG5_130531
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_130531 All targets in OG5_130531
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma mansoni pyruvate dehydrogenase Get druggable targets OG5_127409 All targets in OG5_127409
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K04527 insulin receptor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase Get druggable targets OG5_127409 All targets in OG5_127409
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi hypothetical protein Get druggable targets OG5_129521 All targets in OG5_129521
Echinococcus granulosus serine:threonine protein kinase TAO1 Get druggable targets OG5_129521 All targets in OG5_129521
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127409 All targets in OG5_127409
Echinococcus granulosus STE20 serine:threonine protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni pyruvate dehydrogenase Get druggable targets OG5_127409 All targets in OG5_127409
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129521 All targets in OG5_129521
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_132867 All targets in OG5_132867
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) IKK protein kinase Get druggable targets OG5_132247 All targets in OG5_132247
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi kinase, mitochondrial precursor Get druggable targets OG5_127409 All targets in OG5_127409
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai Get druggable targets OG5_128769 All targets in OG5_128769
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) STE/STE20/TAO protein kinase Get druggable targets OG5_129521 All targets in OG5_129521
Echinococcus granulosus insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127277 All targets in OG5_127277
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) TK/INSR protein kinase Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K00898 pyruvate dehydrogenase kinase [EC2.7.11.2], putative Get druggable targets OG5_127409 All targets in OG5_127409
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus macrophage colony stimulating factor 1 receptor Get druggable targets OG5_132967 All targets in OG5_132967
Candida albicans CDC2-related protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Schistosoma mansoni pyruvate dehydrogenase Get druggable targets OG5_127409 All targets in OG5_127409
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar ot C terminus of S. cerevisiae SGV1 (YPR161C) Get druggable targets OG5_130531 All targets in OG5_130531
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132231 All targets in OG5_132231
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Serine/threonine-protein kinase Nek7 Get druggable targets OG5_131134 All targets in OG5_131134
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus multilocularis STE20 serine:threonine protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense developmentally regulated phosphoprotein Get druggable targets OG5_127409 All targets in OG5_127409
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) TK/ALK protein kinase Get druggable targets OG5_132231 All targets in OG5_132231
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_130670 All targets in OG5_130670
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Serine/threonine-protein kinase NIM1, putative Get druggable targets OG5_132867 All targets in OG5_132867
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi developmentally regulated phosphoprotein, putative Get druggable targets OG5_127409 All targets in OG5_127409
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase Get druggable targets OG5_127409 All targets in OG5_127409
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_127277 All targets in OG5_127277
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni kinase Get druggable targets OG5_130531 All targets in OG5_130531
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Fibroblast growth factor receptor precursor, putative Get druggable targets OG5_128769 All targets in OG5_128769
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense developmentally regulated phosphoprotein, putative Get druggable targets OG5_127409 All targets in OG5_127409
Loa Loa (eye worm) CAMK/CAMKL/NIM1 protein kinase Get druggable targets OG5_132867 All targets in OG5_132867
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130670 All targets in OG5_130670
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127277 All targets in OG5_127277
Trypanosoma brucei developmentally regulated phosphoprotein Get druggable targets OG5_127409 All targets in OG5_127409
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma japonicum Serine/threonine-protein kinase Chk1, putative Get druggable targets OG5_130454 All targets in OG5_130454
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08839 serine/threonine kinase 25, putative Get druggable targets OG5_127277 All targets in OG5_127277
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR008957,Fibronectin, type III-like fold,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Brugia malayi map kinase activated protein kinase protein 2 Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus serine:threonine protein kinase NIM1 Get druggable targets OG5_132867 All targets in OG5_132867
Echinococcus multilocularis cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_132867 All targets in OG5_132867
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi cyclin-dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131134 All targets in OG5_131134
Schistosoma mansoni protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_132867 All targets in OG5_132867
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_132231 All targets in OG5_132231
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_132247 All targets in OG5_132247
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130670 All targets in OG5_130670
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum expressed protein Get druggable targets OG5_132867 All targets in OG5_132867
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein High affinity immunoglobulin gamma Fc receptor I   374 aa 300 aa 22.7 %
Loa Loa (eye worm) hypothetical protein High affinity immunoglobulin gamma Fc receptor I   374 aa 306 aa 22.2 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %
Trypanosoma cruzi Wee1-like protein kinase, putative NIMA-related kinase 6 347 aa 301 aa 24.2 %
Onchocerca volvulus High affinity immunoglobulin gamma Fc receptor I   374 aa 310 aa 20.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase-activated protein kinase 2 370 aa 303 aa 26.4 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 9 372 aa 313 aa 31.6 %
Brugia malayi Immunoglobulin I-set domain containing protein High affinity immunoglobulin gamma Fc receptor I   374 aa 305 aa 18.7 %
Onchocerca volvulus High affinity immunoglobulin gamma Fc receptor I   374 aa 322 aa 21.4 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 11 364 aa 361 aa 33.0 %
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative pyruvate dehydrogenase kinase, isozyme 1 456 aa 397 aa 22.7 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Loa Loa (eye worm) hypothetical protein High affinity immunoglobulin gamma Fc receptor I   374 aa 310 aa 24.2 %
Echinococcus granulosus hemicentin 1 High affinity immunoglobulin gamma Fc receptor I   374 aa 325 aa 20.9 %
Echinococcus multilocularis hemicentin 1 High affinity immunoglobulin gamma Fc receptor I   374 aa 325 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1583 0.1788
Brugia malayi hypothetical protein 0.0034 0.0168 0.025
Loa Loa (eye worm) hypothetical protein 0.0148 0.1562 0.2338
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0068 0.0588 0.088
Echinococcus multilocularis cyclin dependent kinase 0.0114 0.1146 0.1146
Schistosoma mansoni serine/threonine kinase 0.0034 0.0163 0.0183
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0021 0.0012 0.0014
Echinococcus multilocularis protein patched 0.009 0.0854 0.0854
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0087 0.0087
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0162 0.1739 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0321 0.3682 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0297 0.3387 0.5069
Loa Loa (eye worm) hypothetical protein 0.006 0.0486 0.0727
Echinococcus granulosus fibroblast growth factor receptor 4 0.0132 0.1369 0.1547
Echinococcus multilocularis expressed conserved protein 0.0197 0.2164 0.2164
Echinococcus granulosus serine:threonine protein kinase NIM1 0.011 0.1097 0.124
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0008 0.0009
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0034 0.0163 0.0185
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.009 0.0854 0.1278
Echinococcus granulosus nervana 2 0.0025 0.0055 0.0062
Brugia malayi glutaminase DH11.1 0.0255 0.2874 0.4301
Schistosoma mansoni cell adhesion molecule 0.0037 0.0209 0.0235
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0228 0.2539 0.287
Brugia malayi Protein kinase domain containing protein 0.017 0.1831 0.2739
Brugia malayi serine/threonine-protein kinase PAK 7 0.0231 0.258 0.386
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0335 0.0335
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.059 0.16
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Loa Loa (eye worm) transcription factor SMAD2 0.0231 0.2577 0.3857
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0689 0.103
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0008 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0124 0.0184
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0689 0.1868
Loa Loa (eye worm) hypothetical protein 0.0309 0.3533 0.5287
Schistosoma mansoni serine/threonine protein kinase 0.011 0.1097 0.1238
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0008 0.001
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0029 0.011 0.0124
Brugia malayi steroid hormone receptor 0.0021 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Loa Loa (eye worm) hypothetical protein 0.0141 0.1478 0.2212
Loa Loa (eye worm) hypothetical protein 0.0059 0.0473 0.0708
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0036 0.0188 0.0188
Echinococcus granulosus protein kinase c epsilon type 0.0042 0.0271 0.0306
Loa Loa (eye worm) phosphatidylinositol 3 0.0103 0.1011 0.1512
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0068 0.0588 0.3378
Echinococcus granulosus Protein patched homolog 1 0.009 0.0854 0.0965
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0144 0.151 0.1707
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0279 0.0755
Schistosoma mansoni hypothetical protein 0.0743 0.8846 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0008 0.001
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.1146 0.1146
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0027 0.0031
Entamoeba histolytica protein kinase 2, putative 0.0036 0.0188 0.0507
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0046 0.0254
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Loa Loa (eye worm) latrophilin receptor protein 2 0.006 0.0486 0.0727
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.011 0.011
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0103 0.1011 0.5808
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0452 0.1509
Brugia malayi Fibronectin type III domain containing protein 0.0033 0.0153 0.0227
Echinococcus multilocularis tyrosine protein kinase ABL1 0.027 0.306 0.306
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.1384 0.1563
Echinococcus granulosus protein kinase C gamma type 0.0083 0.0764 0.0864
Echinococcus multilocularis mitogen activated protein kinase 14 0.0162 0.1739 0.1739
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0059 0.0473 0.2716
Schistosoma mansoni plexin 0.0021 0.0007 0.0006
Toxoplasma gondii AGC kinase 0.0058 0.0466 0.3922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Echinococcus granulosus raf serine:threonine protein kinase 0.002 0.0002 0.0002
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0072 0.0631 0.3625
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0125 0.1276 0.1443
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.0631 0.3625
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0103 0.1011 0.5808
Schistosoma mansoni tyrosine kinase 0.0025 0.0056 0.0062
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0496 0.1344
Loa Loa (eye worm) hypothetical protein 0.0056 0.0434 0.065
Brugia malayi hypothetical protein 0.0021 0.0012 0.0016
Schistosoma mansoni hypothetical protein 0.013 0.1337 0.151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0008 0.001
Echinococcus granulosus Protein kinase C brain isozyme 0.009 0.0854 0.0965
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.2351 0.2656
Loa Loa (eye worm) hypothetical protein 0.0077 0.0689 0.1031
Echinococcus multilocularis serine threonine protein kinase 0.0083 0.0764 0.0764
Schistosoma mansoni atypical protein kinase C 0.0041 0.0253 0.0284
Loa Loa (eye worm) hypothetical protein 0.0048 0.0335 0.0501
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0065 0.0548 0.082
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0236 0.0351
Giardia lamblia Kinase, CMGC GSK 0.0068 0.0588 0.1594
Brugia malayi Cytochrome P450 family protein 0.005 0.0368 0.0549
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0236 0.0267
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.3533 0.3533
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0252
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2575 0.6991
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0473 0.0534
Loa Loa (eye worm) CAMK/CAMKL/NIM1 protein kinase 0.011 0.1097 0.1641
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0103 0.1011 0.1141
Echinococcus multilocularis aurora kinase A 0.0078 0.0712 0.0712
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0008 0.0009
Echinococcus multilocularis protein kinase c epsilon type 0.0042 0.0271 0.0271
Echinococcus multilocularis serine threonine protein kinase 0.0133 0.1384 0.1384
Onchocerca volvulus 0.0566 0.6682 1
Echinococcus granulosus protein kinase shaggy 0.0068 0.0588 0.0665
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0236 0.0236
Echinococcus multilocularis c src tyrosine kinase 0.0029 0.011 0.011
Plasmodium falciparum serine/threonine protein kinase, putative 0.0078 0.0712 0.5139
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0024 0.0046 0.0046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0689 0.4025
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0038 0.022 0.0319
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0112
Brugia malayi Tyrosine-protein kinase abl-1 0.0125 0.1275 0.1907
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0103 0.1011 0.5808
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Echinococcus granulosus GPCR family 2 0.006 0.0486 0.0549
Brugia malayi SH2 domain containing protein 0.0021 0.0012 0.0016
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.003 0.0116 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0236 0.0638
Echinococcus granulosus roundabout 2 0.0045 0.0297 0.0335
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.1146 0.659
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0271 0.0305
Schistosoma mansoni survival motor neuron protein 0.005 0.0361 0.0407
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0689 0.3959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0536 0.1453
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.003 0.0116 0.0131
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Schistosoma mansoni protein kinase 0.0024 0.0046 0.005
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.006 0.0486 0.0728
Loa Loa (eye worm) hypothetical protein 0.019 0.2071 0.3099
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0689 0.2325
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.034 0.034
Brugia malayi hypothetical protein 0.0031 0.0132 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Loa Loa (eye worm) hypothetical protein 0.0046 0.0319 0.0478
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0024 0.0046 0.0164
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0036 0.0188 0.135
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0059 0.0473 0.0706
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.006 0.0486 0.0486
Onchocerca volvulus 0.0079 0.072 0.1068
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0132 0.1369 0.1369
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus multilocularis roundabout 2 0.0045 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0034 0.0163 0.0244
Brugia malayi protein kinase C II. 0.0042 0.0271 0.0404
Toxoplasma gondii AGC kinase 0.0059 0.0473 0.3987
Echinococcus granulosus hemicentin 1 0.0038 0.022 0.0249
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0059 0.0473 0.2716
Mycobacterium tuberculosis Conserved protein 0.004 0.0236 0.0742
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.1634 0.2444
Echinococcus granulosus serine threonine protein kinase 0.0133 0.1384 0.1564
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.006 0.0486 0.0486
Giardia lamblia Kinase, STE STE20 0.003 0.0116 0.031
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0125 0.1276 0.1276
Entamoeba histolytica protein kinase, putative 0.003 0.0116 0.031
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0059 0.0473 0.2716
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0447 0.0669
Trichomonas vaginalis glutaminase, putative 0.0255 0.2874 0.7805
Echinococcus granulosus expressed conserved protein 0.0197 0.2164 0.2447
Entamoeba histolytica protein kinase, putative 0.0078 0.0712 0.193
Loa Loa (eye worm) SRC-1 0.0029 0.011 0.0165
Echinococcus multilocularis 0.0021 0.0005 0.0005
Echinococcus multilocularis insulin receptor 0.017 0.1831 0.1831
Schistosoma mansoni tyrosine kinase 0.0071 0.0616 0.0695
Brugia malayi Protein kinase domain containing protein 0.0079 0.072 0.1075
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0008 0.0008
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0029 0.011 0.0124
Entamoeba histolytica protein kinase, putative 0.003 0.0116 0.031
Onchocerca volvulus 0.0034 0.0164 0.0235
Brugia malayi Protein kinase c protein 2 0.0067 0.0576 0.086
Schistosoma mansoni fkbp-rapamycin associated protein 0.0026 0.0076 0.0084
Onchocerca volvulus 0.0027 0.0076 0.0104
Echinococcus granulosus geminin 0.0743 0.8846 1
Onchocerca volvulus 0.0029 0.0108 0.0151
Brugia malayi hypothetical protein 0.0141 0.1478 0.221
Trypanosoma brucei cdc2-related kinase 1 0.0114 0.1146 0.659
Onchocerca volvulus 0.011 0.1097 0.1632
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0236 0.1351
Onchocerca volvulus 0.004 0.0236 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0536 0.1453
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0008 0.0008
Schistosoma mansoni nephrin 0.004 0.0241 0.027
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0161
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0029 0.011 0.011
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0689 0.2325
Loa Loa (eye worm) AUR protein kinase 0.0078 0.0712 0.1065
Loa Loa (eye worm) plexin A 0.0025 0.0054 0.0081
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0588 0.1594
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0689 0.3959
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0029 0.011 0.011
Echinococcus granulosus mitogen activated protein kinase 11 0.0162 0.1739 0.1966
Brugia malayi Immunoglobulin I-set domain containing protein 0.0259 0.2918 0.4366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Loa Loa (eye worm) hypothetical protein 0.0103 0.1013 0.1516
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1583 0.1789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Brugia malayi Protein kinase domain containing protein 0.0203 0.2234 0.3342
Brugia malayi hypothetical protein 0.0148 0.1562 0.2336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0496 0.1344
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0153 0.0227
Schistosoma mansoni pyruvate dehydrogenase 0.0144 0.151 0.1706
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.006 0.0486 0.0725
Onchocerca volvulus 0.0027 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0252
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.1146 0.659
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Leishmania major protein kinase A catalytic subunit 0.0059 0.0473 0.2716
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0072 0.0631 0.3625
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0588 0.1594
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0025 0.0055 0.0055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0452 0.1493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0008 0.0012
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0132 0.1369 0.1547
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0133 0.1384 1
Echinococcus granulosus tyrosine kinase 0.0021 0.0012 0.0014
Echinococcus granulosus serine:threonine protein kinase NLK 0.002 0.0001 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Echinococcus granulosus cyclin dependent kinase 9 0.0075 0.0664 0.0751
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0038 0.0218 0.1248
Echinococcus multilocularis CDC7 cell division cycle 7 0.0079 0.072 0.072
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0854 0.2316
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0236 0.0353
Brugia malayi nuclear receptor NHR-88 0.0021 0.0008 0.001
Plasmodium vivax SET domain protein, putative 0.0029 0.0108 0.0769
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0034 0.0163 0.0244
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0021 0.0012 0.0014
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0027 0.0186
Plasmodium falciparum protein kinase, putative 0.0024 0.0046 0.0319
Entamoeba histolytica protein kinase domain containing protein 0.0024 0.0046 0.012
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Entamoeba histolytica protein kinase, putative 0.0133 0.1384 0.3755
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.011 0.0124
Echinococcus multilocularis serine protein kinase ATM 0.0042 0.0262 0.0262
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0447 0.0669
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0008 0.001
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.0163 0.0185
Echinococcus multilocularis cyclin dependent kinase 9 0.0065 0.0548 0.0548
Onchocerca volvulus 0.0021 0.0012 0.0008
Brugia malayi p70 ribosomal S6 kinase beta 0.0058 0.0466 0.0696
Loa Loa (eye worm) AGC/PKA protein kinase 0.0059 0.0473 0.0708
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.0777 0.0777
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0034 0.0163 0.0244
Brugia malayi Protein kinase domain containing protein 0.0114 0.1146 0.1714
Plasmodium falciparum glycogen synthase kinase 3 0.0068 0.0588 0.4246
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0041
Echinococcus multilocularis tyrosine protein kinase Blk 0.0021 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.0021 0.0012 0.0012
Onchocerca volvulus 0.0021 0.0012 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0008 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0059 0.0473 0.2716
Echinococcus granulosus tyrosine protein kinase Blk 0.0021 0.0012 0.0014
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0114 0.1146 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2232 0.3341
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0042 0.0262 0.0295
Brugia malayi hypothetical protein 0.0244 0.274 0.41
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0008 0.0008
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0163 0.0163
Onchocerca volvulus 0.0021 0.0012 0.0008
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus multilocularis raf serine:threonine protein kinase 0.002 0.0002 0.0002
Giardia lamblia Kinase, CMGC CDK 0.0114 0.1146 0.3111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0008 0.0009
Echinococcus multilocularis cyclin dependent kinase 5 0.0114 0.1146 0.1146
Toxoplasma gondii non-specific serine/threonine protein kinase 0.003 0.0113 0.0768
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0689 0.2325
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0029 0.011 0.011
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0103 0.1011 0.5808
Schistosoma mansoni tyrosine kinase 0.017 0.1831 0.2069
Echinococcus multilocularis protein dispatched 1 0.0103 0.101 0.101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0008 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0008 0.001
Echinococcus granulosus lamin dm0 0.0057 0.0447 0.0505
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0236 0.0742
Echinococcus multilocularis nervana 2 0.0025 0.0055 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Echinococcus granulosus tyrosine protein kinase Srms 0.0021 0.0012 0.0014
Echinococcus granulosus Niemann Pick C1 protein 0.03 0.3422 0.3869
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.072 0.1952
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0008 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Echinococcus granulosus cyclin dependent kinase 1 0.0114 0.1146 0.1296
Trypanosoma brucei aurora B kinase 0.0078 0.0712 0.4089
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.274 0.274
Brugia malayi Niemann-Pick C1 protein precursor 0.021 0.232 0.3471
Echinococcus granulosus protein kinase c iota type 0.0041 0.0253 0.0286
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0008 0.0008
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0068 0.0588 0.088
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0027 0.0038
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0059 0.0473 0.2716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0586 0.1589
Onchocerca volvulus 0.0141 0.1478 0.2204
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0535
Echinococcus multilocularis serine:threonine protein kinase NLK 0.002 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0071 0.0616 0.0695
Echinococcus multilocularis plexin a4 0.0025 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.021 0.232 0.3472
Brugia malayi Protein kinase domain containing protein 0.0212 0.2351 0.3516
Onchocerca volvulus 0.0046 0.0319 0.0468
Echinococcus granulosus activin receptor type 0.0024 0.0046 0.0051
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0029 0.011 0.0124
Schistosoma mansoni titin 0.0038 0.022 0.0247
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Echinococcus granulosus low density lipoprotein receptor ldl 0.0027 0.0076 0.0086
Echinococcus granulosus c src tyrosine kinase 0.0029 0.011 0.0124
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0024 0.0046 0.0051
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0026 0.0076 0.0076
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.1146 0.3111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.019 0.2071 0.3097
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0238 0.2666 0.3013
Trypanosoma cruzi polo-like protein kinase, putative 0.0125 0.1276 0.7337
Loa Loa (eye worm) glutaminase 0.0255 0.2874 0.4302
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.021 0.232 0.6299
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0588 0.1594
Schistosoma mansoni kinase 0.0065 0.0548 0.0618
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0565 0.6664 0.7534
Entamoeba histolytica protein kinase, putative 0.0058 0.0466 0.1262
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.0777 0.0777
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0008 0.0012
Loa Loa (eye worm) TK/ABL protein kinase 0.027 0.306 0.4579
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Giardia lamblia Kinase, CMGC CDK 0.0114 0.1146 0.3111
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0238 0.2666 0.2666
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Trichomonas vaginalis STE family protein kinase 0.0133 0.1384 0.3755
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0046 0.0254
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0236 0.0742
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0033 0.0153 0.0153
Trypanosoma brucei developmentally regulated phosphoprotein 0.0144 0.151 0.8683
Loa Loa (eye worm) AGC/PKA protein kinase 0.0059 0.0473 0.0708
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0036 0.0188 0.1074
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0103 0.1011 0.2741
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0078 0.0712 0.0805
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0243 0.0275
Onchocerca volvulus 0.0231 0.2575 0.3847
Echinococcus granulosus Niemann Pick C1 protein 0.021 0.232 0.2623
Loa Loa (eye worm) beta-lactamase 0.004 0.0236 0.0353
Echinococcus multilocularis Immunoglobulin 0.0033 0.0153 0.0153
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0447 0.0667
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.017 0.1831 0.1831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0536 0.1453
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0021 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Brugia malayi nuclear hormone receptor 0.0021 0.0008 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0008 0.0012
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0689 0.2349
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0335 0.0378
Leishmania major phosphatidylinositol 3-kinase, putative 0.0047 0.0327 0.1872
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.013 0.1337 0.1999
Trichomonas vaginalis esterase, putative 0.004 0.0236 0.0638
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.005 0.0367 0.3032
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0212 0.235 0.235
Schistosoma mansoni transcription factor LCR-F1 0.0067 0.0576 0.0649
Echinococcus multilocularis tyrosine protein kinase Abl 0.0125 0.1275 0.1275
Brugia malayi SH2 domain containing protein 0.0021 0.0012 0.0016
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0114 0.1146 0.1296
Giardia lamblia Kinase, CDC7 0.0079 0.072 0.1952
Mycobacterium ulcerans lipase LipD 0.004 0.0236 0.0734
Echinococcus multilocularis lamin dm0 0.0057 0.0447 0.0447
Brugia malayi Serine/threonine-protein kinase SULU 0.0238 0.2666 0.3988
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0368 0.0551
Schistosoma mansoni tyrosine kinase 0.0084 0.0777 0.0877
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0008 0.0008
Leishmania major developmentally regulated phosphoprotein-like protein 0.0144 0.151 0.8683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0262 0.0708
Echinococcus granulosus tyrosine kinase 0.0021 0.0012 0.0014
Plasmodium vivax hypothetical protein, conserved 0.004 0.0236 0.1698
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.1276 0.1441
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0008 0.0008
Schistosoma mansoni protein kinase 0.003 0.0116 0.0129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0452 0.3262
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0103 0.1011 0.1011
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0103 0.1011 0.5808
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0504 0.1364
Schistosoma mansoni serine/threonine protein kinase 0.004 0.024 0.027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0108 0.0108
Schistosoma mansoni kinase 0.0068 0.059 0.0665
Brugia malayi SRC-1 0.0029 0.011 0.0162
Leishmania major protein kinase, putative 0.0024 0.0046 0.0254
Echinococcus multilocularis MAM 0.0034 0.0168 0.0168
Brugia malayi map kinase activated protein kinase protein 2 0.0228 0.2539 0.3798
Echinococcus multilocularis Niemann Pick C1 protein 0.03 0.3422 0.3422
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Schistosoma mansoni protein kinase 0.0203 0.2234 0.2524
Echinococcus multilocularis GPCR, family 2 0.006 0.0486 0.0486
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0236 0.1351
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0008 0.001
Brugia malayi Protein kinase domain containing protein 0.0099 0.0967 0.1445
Loa Loa (eye worm) hypothetical protein 0.025 0.281 0.4206
Loa Loa (eye worm) hypothetical protein 0.0027 0.0087 0.0131
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0236 0.0265
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0236 0.0742
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0033 0.0152 0.0864
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0133 0.1384 0.2071
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0087 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0008 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0203
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.003 0.0116 0.0116
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0103 0.1011 0.1142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0068 0.0588 0.0665
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0027 0.007
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.3533 0.3994
Entamoeba histolytica protein kinase, putative 0.0034 0.0163 0.044
Brugia malayi Latrophilin receptor protein 2 0.006 0.0486 0.0725
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0086 0.0801 0.4601
Onchocerca volvulus 0.005 0.0361 0.0531
Schistosoma mansoni tyrosine kinase 0.0262 0.296 0.3345
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Trichomonas vaginalis STE family protein kinase 0.0133 0.1384 0.3755
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.003 0.0116 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0854 0.0964
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0124 0.0186
Echinococcus granulosus cyclin dependent kinase 9 0.0065 0.0548 0.062
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0059 0.0473 0.3414
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Brugia malayi serine/threonine-protein kinase 6 0.0078 0.0712 0.1063
Brugia malayi serine/threonine kinase 12 0.0078 0.0712 0.1063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0192
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0144 0.151 0.8683
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0854 0.0964
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Echinococcus granulosus tumor protein p63 0.0317 0.3628 0.4102
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0008 0.0008
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.1146 0.1716
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.015 0.1583 0.2367
Giardia lamblia Fructose-bisphosphate aldolase 0.0321 0.3682 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0303
Entamoeba histolytica protein kinase, putative 0.0068 0.0588 0.1594
Brugia malayi ecdysteroid receptor 0.0021 0.0008 0.001
Echinococcus granulosus cyclin dependent kinase 0.0114 0.1146 0.1296
Onchocerca volvulus Netrin receptor homolog 0.0034 0.0164 0.0235
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0367 0.2101
Echinococcus granulosus plexin a4 0.0025 0.0054 0.0061
Echinococcus multilocularis Niemann Pick C1 protein 0.021 0.232 0.232
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0283 0.1619
Giardia lamblia Kinase, CMGC MAPK 0.0072 0.0631 0.1711
Onchocerca volvulus 0.004 0.0236 0.0343
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.0163 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0008 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0108 0.012
Brugia malayi plexin A 0.0025 0.0054 0.0078
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0218 0.0589
Brugia malayi intracellular kinase 0.0068 0.0588 0.0878
Loa Loa (eye worm) hypothetical protein 0.0071 0.0621 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0163 0.044
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0068 0.0588 0.0664
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0072 0.0631 0.3625
Echinococcus multilocularis Immunoglobulin 0.0033 0.0153 0.0153
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0212 0.2351 0.3518
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0321 0.3682 1
Giardia lamblia Kinase, PLK 0.0125 0.1276 0.3463
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.002 0.0001 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0021 0.0012 0.003
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0008 0.0009
Schistosoma mansoni coup transcription factor 0.0021 0.0008 0.0008
Onchocerca volvulus 0.0021 0.0012 0.0008
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0157 0.1672 0.5837
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0108 0.072
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0008 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0473 0.0534
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0027 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0008 0.001
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.1146 0.659
Echinococcus granulosus lamin 0.0057 0.0447 0.0505
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0002 0.0000097908
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.1146 0.659
Brugia malayi kinase, mitochondrial precursor 0.0144 0.151 0.2258
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0259 0.2918 0.4367
Entamoeba histolytica protein kinase , putative 0.0078 0.0712 0.193
Echinococcus granulosus mitogen activated protein kinase 3 0.0072 0.0631 0.0714
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0162 0.1739 1
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0588 0.1594
Echinococcus multilocularis protein kinase shaggy 0.0068 0.0588 0.0588
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.2539 0.2869
Brugia malayi cell division control protein 2 homolog 0.0114 0.1146 0.1714
Echinococcus granulosus insulin receptor 0.017 0.1831 0.207
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0068 0.0588 0.5014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0008 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Brugia malayi intermediate filament protein 0.0057 0.0447 0.0667
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0008 0.0009
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0452 0.3262
Loa Loa (eye worm) hypothetical protein 0.0099 0.0963 0.1442
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0008 0.0012
Echinococcus granulosus serine/threonine protein kinase 0.0038 0.0218 0.0247
Echinococcus multilocularis cyclin dependent kinase 9 0.0075 0.0664 0.0664
Onchocerca volvulus 0.0022 0.0027 0.003
Echinococcus granulosus serine protein kinase ATM 0.0042 0.0262 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0027 0.007
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0047 0.0327 0.0368
Brugia malayi cell division control protein 2 homolog 0.011 0.1097 0.1639
Trypanosoma cruzi Protein kinase B 0.0038 0.0218 0.1248
Echinococcus granulosus tyrosine protein kinase Src42A 0.0029 0.011 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.026 0.293 0.3311
Plasmodium falciparum protein kinase 5 0.0114 0.1146 0.8284
Brugia malayi beta-lactamase family protein 0.004 0.0236 0.0351
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.0163 0.0163
Echinococcus granulosus insulin growth factor 1 receptor beta 0.017 0.1831 0.207
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.011 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1583 0.1788
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.006 0.0486 0.0549
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.002 0.0003 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0008 0.0009
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0367 0.2101
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.1146 0.1716
Loa Loa (eye worm) AUR protein kinase 0.0078 0.0712 0.1065
Leishmania major protein kinase A catalytic subunit isoform 1 0.0059 0.0473 0.2716
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0008 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0076 0.0112
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.011 0.011
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0037 0.0209 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1583 0.1789
Onchocerca volvulus 0.004 0.0236 0.0343
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0029 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Loa Loa (eye worm) TK protein kinase 0.0139 0.1456 0.218
Echinococcus multilocularis activin receptor type 0.0024 0.0046 0.0046
Leishmania major protein kinase A catalytic subunit isoform 2 0.0059 0.0473 0.2716
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0236 0.0742
Echinococcus multilocularis nervana 2 0.0025 0.0055 0.0055
Loa Loa (eye worm) AUR protein kinase 0.0078 0.0712 0.1065
Schistosoma mansoni hypothetical protein 0.0743 0.8846 1
Trypanosoma brucei protein kinase, putative 0.0081 0.0747 0.4294
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Entamoeba histolytica hypothetical protein 0.0042 0.0262 0.0708
Echinococcus multilocularis tyrosine protein kinase shark 0.0021 0.0012 0.0012
Brugia malayi serine/threonine-protein kinase plk-2 0.0125 0.1276 0.1908
Schistosoma mansoni serine/threonine-protein kinase 0.0038 0.0218 0.0245
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0067 0.0576 0.0651
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0103 0.1011 0.2741
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0361 0.0539
Schistosoma mansoni protein kinase 0.003 0.0116 0.0129
Loa Loa (eye worm) haspin protein kinase 0.002 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0008 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0689 0.2349
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Trypanosoma cruzi target of rapamycin kinase 3 0.0086 0.0801 0.4601
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0059 0.0473 0.2716
Brugia malayi CHE-14 protein 0.009 0.0854 0.1276
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Loa Loa (eye worm) hypothetical protein 0.0037 0.0209 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0548 0.0618
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.1146 0.3111
Schistosoma mansoni tyrosine kinase 0.0084 0.0777 0.0877
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0008 0.0009
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0162 0.1739 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0203
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0162 0.1739 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0008 0.001
Brugia malayi Plexin repeat family protein 0.0021 0.0007 0.0009
Loa Loa (eye worm) TK/EGFR protein kinase 0.0084 0.0777 0.1162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0026 0.0076 0.0203
Entamoeba histolytica protein kinase, putative 0.0032 0.0146 0.0393
Entamoeba histolytica serine/threonine protein kinase, putative 0.0125 0.1276 0.3463
Echinococcus multilocularis mitogen activated protein kinase 0.0072 0.0631 0.0631
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0236 0.0742
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0712 0.0803
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0236 0.0638
Brugia malayi Protein kinase domain containing protein 0.0566 0.6682 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0078 0.0712 0.193
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0033 0.0153 0.0171
Schistosoma mansoni pyruvate dehydrogenase 0.0136 0.1412 0.1595
Entamoeba histolytica protein kinase, putative 0.0061 0.0496 0.1345
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0072 0.0631 0.3625
Onchocerca volvulus Tyrosine kinase homolog 0.0255 0.2873 0.4294
Schistosoma mansoni protein kinase 0.0024 0.0046 0.005
Schistosoma mansoni tyrosine kinase 0.0021 0.0012 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0194 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.1011 0.2741
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0163 0.044
Trypanosoma brucei protein kinase, putative 0.0068 0.0588 0.3378
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0236 0.0742
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0021 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase Src64B 0.0029 0.011 0.0124
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0072 0.0631 0.3625
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0854 0.0965
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0103 0.1011 0.1511
Entamoeba histolytica cell division protein kinase 2, putative 0.0123 0.1263 0.3426
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0125 0.1276 0.7337
Entamoeba histolytica protein kinase, putative 0.0078 0.0712 0.193
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0252
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0236 0.1351
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0078 0.0712 0.193
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.072 0.1952
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Entamoeba histolytica protein kinase, putative 0.0032 0.0146 0.0393
Loa Loa (eye worm) hypothetical protein 0.0057 0.0447 0.0669
Onchocerca volvulus 0.0022 0.0027 0.003
Onchocerca volvulus Putative titin 0.0034 0.0164 0.0235
Loa Loa (eye worm) hypothetical protein 0.0045 0.0297 0.0444
Loa Loa (eye worm) IKK protein kinase 0.0566 0.6682 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0103 0.1011 0.5808
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0108 0.012
Loa Loa (eye worm) hypothetical protein 0.0148 0.1562 0.2338
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0144 0.151 0.151
Echinococcus granulosus mitogen activated protein kinase 0.0072 0.0631 0.0714
Brugia malayi MH2 domain containing protein 0.0231 0.2577 0.3856
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0095 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Echinococcus multilocularis mitogen activated protein kinase 11 0.0162 0.1739 0.1739
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0236 0.0638
Mycobacterium tuberculosis Conserved protein 0.004 0.0236 0.0742
Echinococcus granulosus MAM 0.0034 0.0168 0.019
Echinococcus granulosus Cell division cycle 2 protein kinase 0.002 0.0001 0.0002
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0367 0.2101
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.002 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Schistosoma mansoni vesicular amine transporter 0.0033 0.0153 0.0171
Brugia malayi Hr1 repeat family protein 0.0034 0.0163 0.0242
Echinococcus multilocularis Protein kinase C, brain isozyme 0.009 0.0854 0.0854
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0327 0.0489
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0712 0.193
Trypanosoma brucei cdc2-related kinase 3 0.0114 0.1146 0.659
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0008 0.0008
Schistosoma mansoni tyrosine kinase 0.0132 0.1369 0.1546
Leishmania major protein kinase, putative 0.0078 0.0712 0.4089
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0042 0.0271 0.0406
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0236 0.0742
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.072 0.1952
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0059 0.0473 0.3987
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0496 0.1344
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0236 0.0638
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0008 0.0008
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0047 0.0324 0.1855
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0068 0.0588 0.3378
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0689 0.4025
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.0777 0.0878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.1011 0.2741
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0689 0.2325
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0319 0.0359
Toxoplasma gondii FATC domain-containing protein 0.0042 0.0262 0.2099
Schistosoma mansoni tyrosine kinase 0.0032 0.0143 0.016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0689 0.1868
Trypanosoma brucei rac serine-threonine kinase, putative 0.0061 0.0496 0.2849
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0027 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Brugia malayi P38 map kinase family protein 2 0.0162 0.1739 0.2601
Schistosoma mansoni hypothetical protein 0.0034 0.0168 0.0188
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0011
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0029 0.011 0.011
Mycobacterium ulcerans hypothetical protein 0.004 0.0236 0.0734
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0327 0.0487
Schistosoma mansoni glutaminase 0.0255 0.2874 0.3248
Brugia malayi Calcitonin receptor-like protein seb-1 0.019 0.2071 0.3097
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.3533 0.3993
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0548 0.1485
Loa Loa (eye worm) hypothetical protein 0.0055 0.0424 0.0634
Brugia malayi beta-lactamase 0.004 0.0236 0.0351
Schistosoma mansoni tyrosine kinase 0.0084 0.0777 0.0877
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0689 0.1868
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0231 0.258 0.3862
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0036 0.0188 0.135
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0008 0.0002
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0047 0.0327 0.0327
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0689 0.2325
Echinococcus granulosus twitchin 0.0051 0.0374 0.0423
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0072 0.0631 0.5397
Loa Loa (eye worm) hypothetical protein 0.0144 0.151 0.226
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.0163 0.0244
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0114 0.1146 0.1716
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0008 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Echinococcus granulosus aurora kinase A 0.0078 0.0712 0.0805
Brugia malayi beta-lactamase family protein 0.004 0.0236 0.0351
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0112
Onchocerca volvulus 0.0034 0.0168 0.0241
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0086 0.0801 0.4601
Onchocerca volvulus 0.0022 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0554 0.6531 0.9774
Echinococcus multilocularis serine:threonine protein kinase NIM1 0.011 0.1097 0.1097
Echinococcus granulosus NDR protein kinase 0.0034 0.0163 0.0185
Brugia malayi serine/threonine protein kinase 6 0.0078 0.0712 0.1063
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Echinococcus granulosus intermediate filament protein 0.0057 0.0447 0.0505
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0023 0.0029 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Schistosoma mansoni protein kinase 0.0078 0.0712 0.0803
Trypanosoma cruzi polo-like protein kinase, putative 0.0125 0.1276 0.7337
Loa Loa (eye worm) hypothetical protein 0.0099 0.0963 0.1442
Echinococcus multilocularis PAK box P21 Rho binding 0.003 0.0116 0.0116
Plasmodium vivax protein kinase Crk2 0.0114 0.1146 0.8284
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.0163 0.0163
Giardia lamblia Kinase, CMGC GSK 0.0068 0.0588 0.1594
Loa Loa (eye worm) hypothetical protein 0.0033 0.0155 0.0231
Echinococcus multilocularis rac serine:threonine kinase 0.0038 0.0218 0.0218
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.006 0.0486 0.0549
Echinococcus multilocularis tyrosine kinase 0.0021 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Loa Loa (eye worm) glutaminase 2 0.0255 0.2874 0.4302
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0008 0.0012
Toxoplasma gondii target of rapamycin (TOR), putative 0.0081 0.0747 0.643
Plasmodium vivax glycogen synthase kinase 3, putative 0.0068 0.0588 0.4246
Schistosoma mansoni patched 1 0.009 0.0854 0.0964
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0108 0.012
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.034 0.0384
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0236 0.0638
Leishmania major phosphatidylinositol kinase related protein, putative 0.0024 0.0049 0.0271
Schistosoma mansoni hypothetical protein 0.0034 0.0168 0.0188
Echinococcus granulosus mitogen activated protein kinase 14 0.0162 0.1739 0.1966
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0008 0.0008
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0335 0.0335
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0078 0.0712 0.0712
Giardia lamblia Aurora kinase 0.0078 0.0712 0.193
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Echinococcus granulosus neuroglian 0.004 0.0241 0.0272
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0689 0.103
Onchocerca volvulus 0.0068 0.0588 0.0871
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0027 0.007
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0163 0.0163
Echinococcus granulosus tyrosine protein kinase ABL1 0.027 0.306 0.3459
Brugia malayi Pre-SET motif family protein 0.0029 0.0108 0.0159
Leishmania major hypothetical protein, conserved 0.004 0.0236 0.1351
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0262 0.039
Schistosoma mansoni lamin 0.0057 0.0447 0.0504
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Giardia lamblia Kinase, AGC PKA 0.0059 0.0473 0.1282
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.026 0.293 0.4385
Echinococcus granulosus mitogen activated protein kinase 15 0.002 0.0001 0.0002
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0162 0.1739 0.2602
Loa Loa (eye worm) AGC/AKT protein kinase 0.0061 0.0496 0.0743
Loa Loa (eye worm) MH2 domain-containing protein 0.0231 0.2577 0.3857
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.011 0.0124
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0473 0.1282
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.274 0.3098
Echinococcus granulosus serine threonine protein kinase nrc 0.0036 0.0188 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Trypanosoma brucei polo-like protein kinase 0.0125 0.1276 0.7337
Echinococcus granulosus tyrosine protein kinase shark 0.0021 0.0012 0.0014
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.0163 0.0185
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0689 0.2325
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.011 0.0124
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0042 0.0262 0.15
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0008 0.0008
Echinococcus granulosus defective proboscis extension response 0.0033 0.0153 0.0173
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Onchocerca volvulus 0.0057 0.0447 0.0659
Chlamydia trachomatis serine/threonine protein kinase 0.026 0.293 1
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0213 0.236 0.2667
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Loa Loa (eye worm) TK protein kinase 0.0021 0.0012 0.0018
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0036 0.0188 0.0213
Brugia malayi hypothetical protein 0.0067 0.0576 0.0859
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0157 0.1672 0.5777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.076 0.2061
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0212 0.235 0.2657
Loa Loa (eye worm) hypothetical protein 0.0077 0.0689 0.1031
Giardia lamblia GTOR 0.0103 0.1011 0.2741
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0008 0.001
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0072 0.0631 0.0945
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Echinococcus multilocularis lamin 0.0057 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0114 0.1146 0.659
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.1456 0.2178
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0132 0.1369 0.1369
Brugia malayi Furin-like cysteine rich region family protein 0.0084 0.0777 0.116
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0008 0.0008
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0084 0.0777 0.0878
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1583 0.1583
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0033 0.0153 0.0171
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0027 0.0041
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0029 0.011 0.011
Brugia malayi Protein kinase domain containing protein 0.0061 0.0496 0.0741
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0108 0.0122
Mycobacterium tuberculosis Conserved protein 0.004 0.0236 0.0742
Toxoplasma gondii ABC1 family protein 0.004 0.0236 0.1867
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0262 0.15
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Loa Loa (eye worm) TK/INSR protein kinase 0.017 0.1831 0.2741
Toxoplasma gondii AGC kinase 0.0059 0.0473 0.3987
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0854 0.0854
Brugia malayi cyclin-dependent kinase 9 0.0065 0.0548 0.0818
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0631 0.0712
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.015 0.1583 0.2369
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0031 0.0132 0.0148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0114
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0058 0.0464 0.3906
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0169
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0228 0.2539 0.2539
Onchocerca volvulus 0.0027 0.0076 0.0104
Echinococcus multilocularis Glutaredoxin protein 5 0.0025 0.0055 0.0055
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.0163 0.0244
Entamoeba histolytica protein kinase, putative 0.0061 0.0496 0.1345
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Schistosoma mansoni tyrosine kinase 0.0071 0.0616 0.0695
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0218 0.0589
Schistosoma mansoni protein kinase 0.003 0.0116 0.0129
Onchocerca volvulus 0.0021 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.011 0.1102 0.1649
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.1146 0.3111
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0203 0.2234 0.3343
Treponema pallidum fructose-bisphosphate aldolase 0.0321 0.3682 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0029 0.011 0.0123
Mycobacterium ulcerans glutaminase 0.0255 0.2874 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0027 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0047 0.0327 0.0369
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0078 0.0712 0.193
Loa Loa (eye worm) hypothetical protein 0.0244 0.274 0.4101
Loa Loa (eye worm) pigment dispersing factor receptor c 0.019 0.2071 0.3099
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0008 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.1146 0.3111
Mycobacterium ulcerans beta-lactamase 0.004 0.0236 0.0734
Onchocerca volvulus 0.0057 0.0447 0.0659
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0034 0.0163 0.0163
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0228 0.2539 0.38
Loa Loa (eye worm) hypothetical protein 0.0108 0.1077 0.1612
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.003 0.0116 0.0131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0008 0.001
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0144 0.151 0.151
Onchocerca volvulus 0.0034 0.0164 0.0235
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.0631 0.3625
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.1011 0.2741
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0565 0.6664 0.6664
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0473 0.0534
Echinococcus granulosus nervana 2 0.0025 0.0055 0.0062
Echinococcus granulosus Glutaredoxin protein 5 0.0025 0.0055 0.0062
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0046 0.0254
Schistosoma mansoni tyrosine kinase 0.017 0.1831 0.2069
Loa Loa (eye worm) CDC7 protein kinase 0.0079 0.072 0.1077
Schistosoma mansoni lamin 0.0057 0.0447 0.0504
Onchocerca volvulus 0.0034 0.0168 0.0241
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0058 0.0466 0.0698
Schistosoma mansoni pyruvate dehydrogenase 0.0136 0.1412 0.1595
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.2666 0.3012
Echinococcus multilocularis protein kinase c iota type 0.0041 0.0253 0.0253
Brugia malayi hypothetical protein 0.0033 0.0153 0.0227
Trypanosoma brucei protein kinase, putative 0.0024 0.0046 0.0254
Brugia malayi hypothetical protein 0.0238 0.2666 0.3988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0034 0.0163 0.0242
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0572 0.1549
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0008 0.0002
Onchocerca volvulus 0.0077 0.0689 0.1022
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0535
Onchocerca volvulus 0.0021 0.0008 0.0002
Brugia malayi MAP kinase sur-1 0.0072 0.0631 0.0943
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0689 0.3959
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0114 0.1146 0.659
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.1146 0.1146
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0157 0.1672 1
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Brugia malayi Protein kinase domain containing protein 0.0034 0.0163 0.0242
Schistosoma mansoni hypothetical protein 0.0034 0.0164 0.0184
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.059 0.16
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0029 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1583 0.1583
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1146 0.1295
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0049 0.0271
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0023 0.003 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0236 0.0734
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0008 0.001
Schistosoma mansoni hypothetical protein 0.002 0.0003 0.0001
Echinococcus multilocularis mitogen activated protein kinase 3 0.0072 0.0631 0.0631
Brugia malayi Protein kinase domain containing protein 0.0297 0.3388 0.507
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1583 0.1788
Loa Loa (eye worm) oxidoreductase 0.0022 0.0027 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1146 0.1295
Onchocerca volvulus 0.0079 0.072 0.1068
Brugia malayi Protein kinase domain 0.003 0.0116 0.0171
Loa Loa (eye worm) hypothetical protein 0.013 0.1337 0.2001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0067 0.0576 0.0576
Onchocerca volvulus 0.0208 0.2301 0.3436
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0027 0.0029
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.003 0.0116 0.0116
Brugia malayi protein-tyrosine kinase 0.0021 0.0012 0.0016
Mycobacterium leprae Probable lipase LipE 0.004 0.0236 0.1271
Trypanosoma cruzi aurora B kinase, putative 0.0078 0.0712 0.4089
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0078 0.0712 0.5139
Entamoeba histolytica protein kinase rad3, putative 0.0026 0.0076 0.0203
Brugia malayi Pre-SET motif family protein 0.0203 0.2232 0.3339
Echinococcus granulosus contactin 0.0038 0.022 0.0249
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0125 0.1276 0.191
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0238 0.2666 0.3989
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0504 0.1364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0162 0.1739 0.1739
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Echinococcus multilocularis neuroglian 0.004 0.0241 0.0241
Brugia malayi Serine/threonine-protein kinase Nek7 0.026 0.293 0.4384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.068 0.8068 0.9121
Echinococcus multilocularis musashi 0.0057 0.0447 0.0447
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0047 0.0327 0.1872
Giardia lamblia Kinase, AGC PKA 0.0036 0.0188 0.0507
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0026 0.0076 0.0086
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.0163 0.0185
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0068 0.0588 0.0588
Echinococcus granulosus cyclin dependent kinase 5 0.0114 0.1146 0.1296
Echinococcus multilocularis hemicentin 1 0.0038 0.022 0.022
Schistosoma mansoni protein kinase 0.0024 0.0046 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.1392 0.3779
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0008 0.001
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0549 0.1489
Plasmodium falciparum protein kinase, putative 0.0133 0.1384 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0689 0.1031
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0854 0.1278
Mycobacterium ulcerans hypothetical protein 0.0077 0.0689 0.2325
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.2845 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0021 0.0012 0.0012
Brugia malayi FAT domain containing protein 0.002 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Echinococcus multilocularis tumor protein p63 0.0317 0.3628 0.3628
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0008 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0008 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0008 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0152 0.0227
Echinococcus multilocularis mitogen activated protein kinase 14 0.0162 0.1739 0.1739
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0689 0.103
Echinococcus granulosus Immunoglobulin 0.0033 0.0153 0.0173
Schistosoma mansoni hypothetical protein 0.005 0.0361 0.0407
Schistosoma mansoni hypothetical protein 0.0067 0.0576 0.0649
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0572 0.1549
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0059 0.0473 0.2716
Onchocerca volvulus Serine\/threonine kinase homolog 0.0125 0.1276 0.1901
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0059 0.0473 0.3414
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.0777 0.0878
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.002 0.0001 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Mycobacterium leprae conserved hypothetical protein 0.004 0.0236 0.1271
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0027 0.0186
Loa Loa (eye worm) hypothetical protein 0.0086 0.0807 0.1207
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.072 0.0812
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0026 0.0076 0.043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0236 0.0734
Echinococcus granulosus CDC7 cell division cycle 7 0.0079 0.072 0.0814
Onchocerca volvulus 0.0021 0.0012 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0108 0.012
Schistosoma mansoni serine/threonine-protein kinase 0.0038 0.0218 0.0245
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0236 0.0265
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.002 0.0001 0.0001
Entamoeba histolytica p21-activated kinase 0.0032 0.0146 0.0393
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0689 0.2325
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Echinococcus multilocularis geminin 0.0743 0.8846 0.8846
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0025 0.0055 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Schistosoma mansoni intermediate filament proteins 0.0057 0.0447 0.0504
Toxoplasma gondii aurora kinase 0.0078 0.0712 0.6117

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Inhibition of human CYP2D6 ChEMBL. 19115845
Activity (ADMET) Inhibition of human CYP1A2 ChEMBL. 19115845
Activity (ADMET) Inhibition of human CYP3A4 ChEMBL. 19115845
Activity (ADMET) Inhibition of human CYP2C19 ChEMBL. 19115845
Activity (ADMET) Inhibition of human CYP2C9 ChEMBL. 19115845
Activity (ADMET) Inhibition of human CYP2C8 ChEMBL. 19115845
Activity (functional) = 3 % Inhibition of DNA synthesis in human HeLa cells at 3 uM assessed as bromodeoxyuridine incorporation after 24 hrs ChEMBL. 19115845
Activity (functional) = 6 % Inhibition of DNA synthesis in human HeLa cells at 3 uM assessed as bromodeoxyuridine incorporation after 9 hrs ChEMBL. 19115845
Activity (functional) = 16 % Inhibition of DNA synthesis in human HeLa cells at 3 uM assessed as bromodeoxyuridine incorporation after 6 hrs ChEMBL. 19115845
Activity (functional) = 28 % Inhibition of DNA synthesis in human HeLa cells at 3 uM assessed as bromodeoxyuridine incorporation after 3 hrs ChEMBL. 19115845
Activity (functional) = 35 % Inhibition of DNA synthesis in human HeLa cells at 3 uM assessed as bromodeoxyuridine incorporation ChEMBL. 19115845
AUC (ADMET) = 5 uM.hr AUC (0 to infinity) in nu/nu mouse at 10 mg/kg, po administered as single dose ChEMBL. 19115845
AUC (ADMET) = 9.5 uM.hr AUC (0 to infinity) in nu/nu mouse at 10 mg/kg, iv administered as single dose ChEMBL. 19115845
CL (ADMET) = 3.7 L/hr/kg Clearance in nu/nu mouse at 10 mg/kg, iv administered as single dose ChEMBL. 19115845
Cmax (ADMET) = 2.6 uM Cmax in nu/nu mouse at 10 mg/kg, po administered as single dose ChEMBL. 19115845
Cmax (ADMET) = 20.3 uM Cmax in nu/nu mouse at 10 mg/kg, iv administered as single dose ChEMBL. 19115845
F (ADMET) = 53 % Oral bioavailability in nu/nu mouse at 10 mg/kg administered as single dose ChEMBL. 19115845
IC50 (binding) = 0.002 uM Inhibition of human Cdc7 assessed as inhibition of rate of phosphorylation of Mcm2 protein ChEMBL. 19115845
IC50 (binding) = 0.028 uM Inhibition of CDK9 ChEMBL. 19115845
IC50 (binding) = 0.126 uM Inhibition of TAO3 ChEMBL. 19115845
IC50 (binding) = 0.138 uM Inhibition of Cdk2A ChEMBL. 19115845
IC50 (binding) = 0.146 uM Inhibition of GSK3-beta ChEMBL. 19115845
IC50 (functional) = 0.5 uM Antiproliferative activity against human A2780 cells after 72 hrs by luciferase based assay ChEMBL. 19115845
IC50 (functional) = 0.5 uM Antiproliferative activity against human COLO205 cells after 72 hrs by luciferase based assay ChEMBL. 19115845
IC50 (binding) = 0.51 uM Inhibition of MK2 ChEMBL. 19115845
IC50 (binding) = 0.574 uM Inhibition of PLK1 ChEMBL. 19115845
IC50 (binding) = 0.846 uM Inhibition of ERK2 ChEMBL. 19115845
IC50 (functional) = 0.9 uM Antiproliferative activity against human SW48 cells after 72 hrs by luciferase based assay ChEMBL. 19115845
IC50 (functional) = 1.1 uM Antiproliferative activity against human MCF7 cells after 72 hrs by luciferase based assay ChEMBL. 19115845
IC50 (binding) = 1.149 uM Inhibition of PKCbeta ChEMBL. 19115845
IC50 (functional) = 1.3 uM Antiproliferative activity against human L363 cells after 72 hrs by luciferase based assay ChEMBL. 19115845
IC50 (ADMET) = 1.6 uM Antiproliferative activity against human NHDF cells after 72 hrs by luciferase based assay ChEMBL. 19115845
IC50 (binding) = 1.62 uM Inhibition of CDK5/p25 ChEMBL. 19115845
IC50 (functional) = 3.7 uM Antiproliferative activity against human OPM2 cells after 72 hrs by luciferase based assay ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of ABL ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of AKT1 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of ALK ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of AUR2 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of CDK4 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of CHK1 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of FGFR1 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of IGFR1 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of IKKi ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of IR ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of KIT ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of LCK ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of MET ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of NEK6 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of NIM1 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of PAK4 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of PDK1 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of PKAalpha ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of P38beta ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of RET ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of VEGFR3 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of TRKA ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of MST4 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of STLK2 ChEMBL. 19115845
IC50 (binding) > 4 uM Inhibition of AUR1 ChEMBL. 19115845
IC50 (functional) = 4.1 uM Antiproliferative activity against human HT-29 cells after 72 hrs by luciferase based assay ChEMBL. 19115845
MED (binding) = 0.6 uM Inhibition of human Cdc7 in human A2780 cells assessed as inhibition of Ser53 phosphorylation of Mcm2 protein after 4 hrs ChEMBL. 19115845
MED (binding) = 3 uM Inhibition of human Cdc7 in human A2780 cells assessed as inhibition of Ser40 phosphorylation of Mcm2 protein after 4 hrs ChEMBL. 19115845
Stability (ADMET) = 95 % Metabolic stability in human hepatocytes expressing CYP3A4 assessed as drug remaining after 1 hr ChEMBL. 19115845
T1/2 (ADMET) = 1 hr Half life in nu/nu mouse at 10 mg/kg, po administered as single dose ChEMBL. 19115845
T1/2 (ADMET) = 1 hr Half life in nu/nu mouse at 10 mg/kg, iv administered as single dose ChEMBL. 19115845
TGI (functional) = 68 % Antitumor activity against human A2780 cells xenografted in CDI nu/nu mouse assessed as tumor growth inhibition at 60 mg/kg, po administered for 10 days ChEMBL. 19115845
Tmax (ADMET) = 0.5 hr Tmax in nu/nu mouse at 10 mg/kg, po administered as single dose ChEMBL. 19115845
Vdss (ADMET) = 2.6 L/Kg Volume of distribution at steady state in nu/nu mouse at 10 mg/kg, iv administered as single dose ChEMBL. 19115845

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19115845

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.