Detailed information for compound 1362675

Basic information

Technical information
  • TDR Targets ID: 1362675
  • Name: (4S)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl ]oxolan-2-one; nitric acid
  • MW: 271.27 | Formula: C11H17N3O5
  • H donors: 0 H acceptors: 5 LogP: -0.3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)O.CCC1C(=O)OC[C@H]1Cc1cncn1C
  • InChi: 1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10?;/m1./s1
  • InChiKey: PRZXEPJJHQYOGF-GLXCQHJISA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4S)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]tetrahydrofuran-2-one; nitric acid
  • (4S)-3-ethyl-4-[(3-methyl-4-imidazolyl)methyl]-2-tetrahydrofuranone; nitric acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0025 0.0002 0.0002
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.023 0.0632 0.5748
Plasmodium falciparum ornithine aminotransferase 0.0091 0.0204 0.2576
Mycobacterium tuberculosis Probable reductase 0.0209 0.0567 0.2013
Loa Loa (eye worm) hypothetical protein 0.0122 0.0301 0.03
Loa Loa (eye worm) hypothetical protein 0.0062 0.0114 0.0114
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0031 0.0021 0.0111
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0044 0.0059 0.0059
Brugia malayi MBOAT family protein 0.3273 0.9999 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0068 0.0132 0.0132
Brugia malayi Bromodomain containing protein 0.0081 0.0175 0.0175
Trypanosoma cruzi cytochrome P450, putative 0.0049 0.0075 0.0666
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0209 0.0567 0.2013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0132 0.0132
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.001 0.007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0031 0.0021 0.0111
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0058 0.0104 0.0104
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.011 0.0263 0.2376
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0235 0.1056
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0022 0.0071
Echinococcus granulosus allatostatin A receptor 0.0044 0.0059 0.0059
Schistosoma mansoni amine GPCR 0.0044 0.0059 0.0059
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.0206 0.0206
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.037 0.3373
Echinococcus granulosus snurportin 1 0.0299 0.0845 0.0845
Schistosoma mansoni survival motor neuron protein 0.0099 0.0228 0.0228
Echinococcus granulosus neuropeptide s receptor 0.1446 0.4373 0.4374
Onchocerca volvulus 0.0032 0.0022 0.008
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0282 0.0792 0.0792
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0022 0.0199
Loa Loa (eye worm) inositol-1 0.011 0.0263 0.0262
Brugia malayi PHD-finger family protein 0.0061 0.0113 0.0113
Onchocerca volvulus Neuropeptide F receptor homolog 0.0044 0.0059 0.0248
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0032 0.0022 0.0022
Brugia malayi hypothetical protein 0.0044 0.0059 0.0059
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0382 0.1098 0.1098
Schistosoma mansoni lipoxygenase 0.0236 0.0652 0.0652
Brugia malayi Dopamine receptor protein 2 0.0044 0.0059 0.0059
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0031 0.0021 0.0191
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0022 0.0453
Mycobacterium ulcerans hypothetical protein 0.0161 0.0421 0.2223
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0068 0.0132 0.0132
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.0377 0.1338
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.064 0.1893 0.672
Schistosoma mansoni RAR-like nuclear receptor 0.0068 0.0132 0.0132
Trypanosoma cruzi glycerol uptake protein, putative 0.0282 0.0792 0.7209
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0282 0.0792 0.0792
Echinococcus multilocularis G-protein coupled receptor, putative 0.0044 0.0059 0.0059
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.0238 0.0238
Trypanosoma cruzi ISWI complex protein 0.0031 0.002 0.0162
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus multilocularis GPCR, family 2 0.0065 0.0125 0.0125
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0046 0.067
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Brugia malayi hypothetical protein 0.0036 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0147 0.0377 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0377 0.1713
Loa Loa (eye worm) hypothetical protein 0.0282 0.0792 0.0792
Schistosoma mansoni bromodomain containing protein 0.0139 0.0353 0.0353
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0181 0.0482 0.525
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0068 0.0132 0.0132
Echinococcus granulosus g protein coupled receptor 0.0044 0.0059 0.0059
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0382 0.1098 0.5049
Echinococcus granulosus alpha 1A adrenergic receptor 0.0044 0.0059 0.0059
Brugia malayi hypothetical protein 0.0044 0.0059 0.0059
Schistosoma mansoni smad1 5 8 and 0.0025 0.0001 0.0001
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.0087 0.0087
Brugia malayi GnHR receptor homolog 0.0044 0.0059 0.0059
Plasmodium falciparum glutathione reductase 0.0032 0.0022 0.0276
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0147 0.0377 0.0377
Echinococcus granulosus 7TM GPCR rhodopsin 0.0044 0.0059 0.0059
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.0206 0.0731
Onchocerca volvulus 0.0044 0.0059 0.0248
Echinococcus granulosus mixed lineage leukemia protein mll 0.0034 0.0029 0.0029
Plasmodium vivax ornithine aminotransferase, putative 0.0091 0.0204 0.2576
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.0206 0.26
Schistosoma mansoni amine GPCR 0.0044 0.0059 0.0059
Onchocerca volvulus 0.0044 0.0059 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0104 0.0451
Loa Loa (eye worm) doublecortin family protein 0.0062 0.0114 0.0114
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0022 0.0453
Onchocerca volvulus 0.0122 0.0301 0.1365
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus granulosus neuropeptide receptor A26 0.1446 0.4373 0.4374
Echinococcus granulosus tachykinin peptides receptor 99D 0.0044 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0044 0.0059 0.0059
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0042 0.0053 0.0214
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.0393 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.001 0.0018
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0282 0.0792 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0005 0.0005
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0382 0.1098 0.5049
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0147 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0065 0.0125 0.0125
Brugia malayi diacylglycerol acyltransferase 0.0282 0.0792 0.0792
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0321 0.0321
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0047 0.07
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0082 0.0177 0.0176
Echinococcus multilocularis 0.0047 0.007 0.0069
Mycobacterium tuberculosis Probable dehydrogenase 0.0209 0.0567 0.2013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0046 0.0398
Schistosoma mansoni loxhd1 0.0062 0.0114 0.0114
Trichomonas vaginalis helicase, putative 0.0028 0.001 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0022 0.0022
Toxoplasma gondii cytochrome p450 superfamily protein 0.0031 0.0021 0.0229
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.1313
Trypanosoma cruzi cytochrome P450, putative 0.0049 0.0075 0.0666
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.0209 0.0742
Echinococcus multilocularis muscleblind protein 1 0.1692 0.5133 0.5132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.051 0.1494 0.1494
Echinococcus multilocularis microtubule associated protein 2 0.1429 0.4321 0.4321
Trichomonas vaginalis esterase, putative 0.0147 0.0377 0.1713
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0031 0.0021 0.0075
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0181 0.0482 1
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.0377 0.1338
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0147 0.0377 1
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1216 0.5596
Echinococcus granulosus mitogen activated protein kinase 3 0.0101 0.0235 0.0235
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.0104 0.0947
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0044 0.0059 0.0059
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.023 0.0632 0.2893
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.0059 0.0059
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0057 0.0499
Schistosoma mansoni Smad4 0.0025 0.0001 0.0001
Schistosoma mansoni zinc finger protein 0.0032 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Mycobacterium leprae conserved hypothetical protein 0.0151 0.039 0.2062
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.0059 0.0059
Echinococcus multilocularis zinc finger protein 0.005 0.0079 0.0079
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.056 0.0559
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0058 0.0104 0.0104
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.0022 0.0022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0125 0.0125
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0046 0.0415
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Brugia malayi hypothetical protein 0.0044 0.0059 0.0059
Plasmodium falciparum thioredoxin reductase 0.0032 0.0022 0.0276
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Mycobacterium ulcerans putative regulatory protein 0.0151 0.039 0.2062
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0031 0.0021 0.0191
Loa Loa (eye worm) hypothetical protein 0.0058 0.0104 0.0104
Plasmodium vivax importin-beta 2, putative 0.0028 0.001 0.0131
Brugia malayi Nuclear hormone receptor E75 0.0032 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0104 0.0104
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0282 0.0792 0.0792
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0149 0.0149
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0044 0.0059 0.0059
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0022 0.0115
Echinococcus granulosus fmrfamide receptor 0.0044 0.0059 0.0059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0029 0.0029
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.011 0.0263 0.1387
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0209 0.0567 0.2995
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0147 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0042 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Brugia malayi Tachykinin-like peptides receptor 99D 0.0044 0.0059 0.0059
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0044 0.0059 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0032 0.0022 0.0022
Loa Loa (eye worm) cytochrome P450 0.0031 0.0021 0.0021
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0058 0.0104 0.0104
Brugia malayi Nuclear hormone receptor-like 1 0.0068 0.0132 0.0132
Trichomonas vaginalis inositol monophosphatase, putative 0.011 0.0263 0.1184
Toxoplasma gondii thioredoxin reductase 0.0092 0.0206 0.2243
Echinococcus granulosus zinc finger protein 0.005 0.0079 0.0079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0068 0.0132 0.0132
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.0206 0.0206
Echinococcus granulosus g protein coupled receptor 0.0044 0.0059 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0154 0.068
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0022 0.0453
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0022 0.0181
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0034 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0111 0.0266 0.0266
Brugia malayi hypothetical protein 0.0044 0.0059 0.0059
Loa Loa (eye worm) CXXC zinc finger family protein 0.0124 0.0305 0.0305
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0058 0.0104 0.0947
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0031 0.0021 0.0111
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0154 0.068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0068 0.0132 0.0132
Brugia malayi ORL1-like opioid receptor 0.0044 0.0059 0.0059
Brugia malayi Protein kinase domain containing protein 0.0049 0.0074 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0068 0.0132 0.0132
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0382 0.1098 0.5049
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0377 0.1713
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0282 0.0792 1
Echinococcus granulosus G protein coupled receptor 139 0.0044 0.0059 0.0059
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.0377 0.0377
Onchocerca volvulus 0.0102 0.0238 0.1076
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0104 0.0104
Loa Loa (eye worm) steroid hormone receptor 0.0068 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0078 0.0164 0.0164
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.037 0.3361
Onchocerca volvulus 0.0729 0.2169 1
Brugia malayi AMP-binding enzyme family protein 0.0077 0.016 0.0159
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Brugia malayi M-phase phosphoprotein, mpp8 0.0122 0.0301 0.03
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0132 0.033 0.033
Echinococcus granulosus g-protein coupled receptor 0.0044 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0068 0.0132 0.0132
Onchocerca volvulus 0.0044 0.0059 0.0248
Trichomonas vaginalis transmembrane protein nessy, putative 0.0282 0.0792 0.3634
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Onchocerca volvulus 0.0044 0.0059 0.0248
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Brugia malayi Melatonin receptor type 1A 0.0044 0.0059 0.0059
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.0845 0.0845
Loa Loa (eye worm) glutathione reductase 0.0092 0.0206 0.0206
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.0059 0.0059
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.1313
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.0022 0.0022
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.0059 0.0059
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0282 0.0792 1
Brugia malayi AMP-binding enzyme family protein 0.0077 0.016 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.001 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0022 0.0022
Giardia lamblia Kinase, CMGC MAPK 0.0101 0.0235 0.6002
Plasmodium vivax glutathione reductase, putative 0.0092 0.0206 0.26
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.0451
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.051 0.1494 0.1494
Brugia malayi Importin beta-1 subunit 0.0028 0.001 0.001
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.001 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0126 0.0126
Toxoplasma gondii hypothetical protein 0.0151 0.039 0.425
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0382 0.1098 0.1098
Schistosoma mansoni alpha-1 adrenergic receptor 0.0044 0.0059 0.0059
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0301 0.0851 0.0851
Loa Loa (eye worm) hypothetical protein 0.0086 0.019 0.019
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0044 0.0059 0.0059
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0058 0.0104 0.0104
Brugia malayi conserved hypotetical protein 0.0032 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.0147 0.0377 0.1991
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0068 0.0132 0.0132
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0022 0.0022
Echinococcus granulosus 7tm_1 domain containing protein 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0031 0.0021 0.0075
Onchocerca volvulus Protein ultraspiracle homolog 0.0068 0.0132 0.0589
Loa Loa (eye worm) hypothetical protein 0.0369 0.1058 0.1058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.009 0.0321
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.3273 0.9999 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0635 0.1879 0.1879
Schistosoma mansoni lamin 0.0026 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0053 0.0214
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0031 0.0021 0.0075
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0005 0.0005
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0058 0.0104 0.0451
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0022 0.0199
Schistosoma mansoni biogenic amine receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) acetyltransferase 0.0152 0.0393 0.0393
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0577 0.1699 0.1699
Echinococcus multilocularis mitogen activated protein kinase 3 0.0101 0.0235 0.0235
Echinococcus multilocularis neuropeptide s receptor 0.1446 0.4373 0.4373
Schistosoma mansoni ap endonuclease 0.0039 0.0046 0.0045
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0022 0.0276
Brugia malayi follicle stimulating hormone receptor 0.1937 0.5886 0.5887
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0108 0.0257 0.0257
Echinococcus multilocularis somatostatin receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) hhat protein 0.0282 0.0792 0.0792
Schistosoma mansoni lipoxygenase 0.0126 0.031 0.031
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0091 0.0204 0.2222
Loa Loa (eye worm) hypothetical protein 0.0282 0.0792 0.0792
Toxoplasma gondii aldehyde dehydrogenase 0.0301 0.0851 0.9271
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0058 0.0104 0.0104
Echinococcus granulosus muscleblind protein 0.1692 0.5133 0.5133
Echinococcus granulosus neuropeptide FF receptor 2 0.0044 0.0059 0.0059
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0214 0.0214
Echinococcus granulosus insulin receptor 0.0049 0.0074 0.0074
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0101 0.0235 0.2125
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0031 0.0021 0.0075
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0031 0.0021 0.0111
Echinococcus granulosus o acyltransferase membrane bound domain 0.0282 0.0792 0.0792
Brugia malayi nuclear receptor NHR-88 0.0032 0.0022 0.0022
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.0059 0.0059
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0022 0.0276
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0022 0.0181
Brugia malayi larval opioid receptor 0.0044 0.0059 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.023 0.0632 0.2893
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0101 0.0235 0.2558
Brugia malayi glutathione reductase 0.0092 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0196 0.0195
Echinococcus multilocularis Smad4 0.0025 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0301 0.0851 0.4498
Brugia malayi beta-lactamase family protein 0.0147 0.0377 0.0377
Schistosoma mansoni zinc finger protein 0.3273 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0031 0.0031
Schistosoma mansoni cpg binding protein 0.0135 0.0339 0.0338
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0114 0.0114
Toxoplasma gondii exonuclease III APE 0.0039 0.0046 0.0497
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Onchocerca volvulus 0.0068 0.0132 0.0589
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0031 0.0021 0.0111
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0031 0.0021 0.0075
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0058 0.0104 0.0931
Brugia malayi nuclear receptor NHR-67 0.0032 0.0022 0.0022
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0194 0.0194
Echinococcus multilocularis thyroid hormone receptor alpha 0.0068 0.0132 0.0132
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0228 0.0228
Giardia lamblia hypothetical protein 0.0058 0.0104 0.2316
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.0867 0.7892
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0114 0.0114
Echinococcus multilocularis Aminotransferase class III 0.0091 0.0204 0.0204
Echinococcus multilocularis fmrfamide receptor 0.0044 0.0059 0.0059
Schistosoma mansoni importin beta-1 0.0028 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Mycobacterium ulcerans acetylornithine aminotransferase 0.0091 0.0204 0.1078
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.0059 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0377 0.3421
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0031 0.0021 0.0075
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0147 0.0377 0.4757
Mycobacterium ulcerans L-lysine aminotransferase 0.0091 0.0204 0.1078
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0098 0.0227 0.0806
Mycobacterium ulcerans hypothetical protein 0.064 0.1893 1
Leishmania major alpha glucosidase II subunit, putative 0.0075 0.0154 0.1399
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0057 0.0499
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.039 0.1775
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.0451
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0059 0.0059
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0091 0.0204 0.4233
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0154 0.068
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0058 0.0104 0.0104
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0282 0.0792 0.0792
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0087 0.0191 0.019
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0053 0.0053
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0091 0.0204 0.1078
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0104 0.0931
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0068 0.0132 0.0132
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0053 0.0214
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.01 0.2076
Loa Loa (eye worm) TK/INSR protein kinase 0.0049 0.0074 0.0074
Mycobacterium ulcerans putative regulatory protein 0.0151 0.039 0.2062
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Loa Loa (eye worm) MBOAT family protein 0.0282 0.0792 0.0792
Brugia malayi hypothetical protein 0.0062 0.0114 0.0114
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0046 0.0162
Onchocerca volvulus 0.0282 0.0792 0.3638
Onchocerca volvulus 0.0147 0.0377 0.1719
Schistosoma mansoni neuropeptide receptor 0.0044 0.0059 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.051 0.1494 0.1494
Trypanosoma brucei protein kinase, putative 0.0101 0.0235 0.2139
Loa Loa (eye worm) hypothetical protein 0.0057 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0003
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0232 0.0639 0.2267
Brugia malayi MBOAT family protein 0.0282 0.0792 0.0792
Plasmodium vivax SET domain protein, putative 0.0094 0.0214 0.2705
Brugia malayi nuclear receptor RXR 0.0032 0.0022 0.0022
Leishmania major cytochrome p450-like protein 0.0031 0.0021 0.0191
Leishmania major glycerol uptake protein, putative 0.0282 0.0792 0.7214
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.016 0.0567
Schistosoma mansoni tyrosine kinase 0.0049 0.0074 0.0074
Trichomonas vaginalis maltase-glucoamylase, putative 0.0075 0.0154 0.068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0059 0.0059
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.016 0.0843
Loa Loa (eye worm) hypothetical protein 0.0057 0.01 0.01
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0058 0.0104 0.0104
Trichomonas vaginalis sucrase-isomaltase, putative 0.0075 0.0154 0.068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0059 0.0059
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0022 0.0199
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0057 0.0499
Echinococcus multilocularis ornithine aminotransferase 0.0091 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0022 0.0181
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0053 0.0214
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0101 0.0235 0.2139
Plasmodium falciparum phosphodiesterase gamma, putative 0.0058 0.0104 0.1313
Brugia malayi Pre-SET motif family protein 0.0094 0.0214 0.0214
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0044 0.0059 0.0059
Echinococcus granulosus lamin 0.0026 0.0005 0.0005
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0044 0.0059 0.0059
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0044 0.0059 0.0059
Onchocerca volvulus Huntingtin homolog 0.0369 0.1058 0.4868
Mycobacterium ulcerans aldehyde dehydrogenase 0.0301 0.0851 0.4498
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.064 0.1893 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0005 0.0005
Schistosoma mansoni nuclear receptor 0.0032 0.0022 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0125 0.0125
Echinococcus granulosus importin subunit beta 1 0.0028 0.001 0.001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0097 0.0222 0.0998
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.001 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0301 0.0851 0.0851
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0031 0.0021 0.0075
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0036 0.0034 0.0034
Brugia malayi Cytochrome P450 family protein 0.0031 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0282 0.0792 0.7214
Echinococcus granulosus RUN 0.0062 0.0114 0.0114
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0091 0.0204 0.1078
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0059 0.0059
Echinococcus granulosus smad 0.0025 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0077 0.016 0.0159
Loa Loa (eye worm) hypothetical protein 0.0147 0.0377 0.0377
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0101 0.0235 0.0235
Brugia malayi hypothetical protein 0.0044 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0059 0.0059
Toxoplasma gondii GAF domain-containing protein 0.0151 0.039 0.425
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0068 0.0132 0.0132
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.0377 0.0377
Loa Loa (eye worm) histone methyltransferase 0.0042 0.0052 0.0052
Schistosoma mansoni neuropeptide f receptor 76f 0.0044 0.0059 0.0059
Brugia malayi MH1 domain containing protein 0.0025 0.0001 0.0001
Brugia malayi cytochrome P450 0.0031 0.0021 0.0021
Echinococcus granulosus sterol O acyltransferase 1 0.0282 0.0792 0.0792
Brugia malayi sulfakinin receptor protein 0.0044 0.0059 0.0059
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.001 0.007
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0058 0.0104 0.0947
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0002 0.0025
Echinococcus multilocularis FTZ F1 alpha 0.0068 0.0132 0.0132
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.001 0.0014
Brugia malayi Inositol-1 0.011 0.0263 0.0262
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0109 0.0258 0.0258
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0031 0.0021 0.0111
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.011 0.0263 0.239
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0104 0.0931
Echinococcus multilocularis ubiquitin specific protease 41 0.0147 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Trypanosoma brucei trypanothione reductase 0.0092 0.0206 0.1875
Echinococcus granulosus Smad4 0.0025 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0235 0.1056
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.001 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0377 0.1713
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.1049 0.1049
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0154 0.1383
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1937 0.5886 0.5887
Loa Loa (eye worm) hypothetical protein 0.0147 0.0377 0.0377
Echinococcus multilocularis zinc finger protein 0.2991 0.913 0.913
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0266 0.0266
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0032 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0068 0.0132 0.0132
Onchocerca volvulus 0.0044 0.0059 0.0248
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0002
Echinococcus granulosus peptide allatostatin:somatostatin 0.0044 0.0059 0.0059
Onchocerca volvulus 0.0044 0.0059 0.0248
Echinococcus multilocularis fmrfamide receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) MBOAT family protein 0.3273 0.9999 1
Echinococcus granulosus somatostatin receptor 0.0044 0.0059 0.0059
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0022 0.0276
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0232 0.0639 0.3374
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0369 0.1058 0.1058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0059 0.0059
Brugia malayi putative neuropeptide receptor 0.0044 0.0059 0.0059
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0098 0.0227 0.12
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.001 0.0021
Echinococcus multilocularis G protein coupled receptor 139 0.0044 0.0059 0.0059
Trypanosoma brucei glycerol uptake protein, putative 0.0282 0.0792 0.7214
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0058 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0147 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0141 0.0358 0.0358
Mycobacterium tuberculosis Probable aminotransferase 0.064 0.1893 0.672
Echinococcus multilocularis orexin receptor type 2 0.0044 0.0059 0.0059
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0382 0.1098 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.0377 0.1991
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0042 0.0368
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0046 0.0045
Mycobacterium leprae conserved hypothetical protein 0.0147 0.0377 0.1991
Mycobacterium tuberculosis Conserved protein 0.0147 0.0377 0.1338
Trypanosoma cruzi GUP1, putative 0.0282 0.0792 0.7209
Schistosoma mansoni hypothetical protein 0.0062 0.0114 0.0114
Entamoeba histolytica hypothetical protein 0.0111 0.0266 0.3359
Echinococcus multilocularis ecdysone induced protein 78C 0.0068 0.0132 0.0132
Trypanosoma brucei cytochrome P450, putative 0.0049 0.0075 0.0683
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.016 0.2015
Brugia malayi AMP-binding enzyme family protein 0.0077 0.016 0.0159
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.0059 0.0059
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0001 0.0001
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.01 0.1263
Brugia malayi tailless protein 0.0032 0.0022 0.0022
Brugia malayi neuropeptide F receptor 0.0044 0.0059 0.0059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0022 0.0181
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0058 0.0104 0.0104
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.001 0.0095
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0042 0.0053 0.0214
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Leishmania major hypothetical protein, conserved 0.0025 0.0002 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0031 0.0021 0.0075
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0109 0.0258 0.0258
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0075 0.0154 0.0153
Loa Loa (eye worm) PDE1B protein 0.0058 0.0104 0.0104
Brugia malayi hypothetical protein 0.0044 0.0059 0.0059
Echinococcus multilocularis serotonin receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.0059 0.0059
Trypanosoma brucei glycerol uptake protein, putative 0.0282 0.0792 0.7214
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0282 0.0792 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0068 0.0132 0.0132
Brugia malayi MH1 domain containing protein 0.0025 0.0001 0.0001
Echinococcus granulosus cytochrome P450 2K1 0.0031 0.0021 0.0021
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0382 0.1098 0.5049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0059 0.0059
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0036 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.0132
Loa Loa (eye worm) nuclear hormone receptor 0.0032 0.0022 0.0022
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0382 0.1098 0.5049
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0058 0.0104 0.0104
Echinococcus multilocularis tumor protein p63 0.0697 0.2068 0.2068
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0101 0.0235 0.2125
Loa Loa (eye worm) hypothetical protein 0.1692 0.5133 0.5133
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0792 0.3634
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0297 0.0837 0.0837
Echinococcus multilocularis lysosomal alpha glucosidase 0.0336 0.0958 0.0958
Echinococcus granulosus dnaJ subfamily B 0.1307 0.3945 0.3946
Schistosoma mansoni hypothetical protein 0.0044 0.0059 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0068 0.0132 0.0132
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0073 0.0306
Onchocerca volvulus 0.0077 0.016 0.0714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0321 0.0321
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0091 0.0204 0.1078
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.011 0.0263 0.239
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0421 0.1494
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Brugia malayi hypothetical protein 0.0122 0.0301 0.03
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0377 0.1713
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0021 0.0173
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0068 0.0132 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0132 0.0132
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.0377 0.1991
Trichomonas vaginalis conserved hypothetical protein 0.0323 0.0918 0.4217
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0149 0.0149
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0194 0.0194
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.0022 0.0022
Brugia malayi Hhat protein 0.0282 0.0792 0.0792
Plasmodium falciparum GAF domain-related protein, putative 0.0151 0.039 0.4927
Entamoeba histolytica hypothetical protein 0.0111 0.0266 0.3359
Schistosoma mansoni microtubule-associated protein tau 0.1429 0.4321 0.4322
Onchocerca volvulus 0.0044 0.0059 0.0248
Chlamydia trachomatis endonuclease IV 0.0093 0.0209 0.4335
Brugia malayi Cytochrome P450 family protein 0.0049 0.0075 0.0075
Brugia malayi MH2 domain containing protein 0.0366 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Loa Loa (eye worm) RNA binding protein 0.0066 0.0126 0.0126
Toxoplasma gondii histone lysine methyltransferase SET1 0.0246 0.0682 0.7423
Treponema pallidum NADH oxidase 0.0032 0.0022 0.0276
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0104 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.009 0.0321
Echinococcus granulosus ecdysone induced protein 78C 0.0068 0.0132 0.0132
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0021 0.0173
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0022 0.0199
Schistosoma mansoni hypothetical protein 0.0099 0.0228 0.0228
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.064 0.1893 0.8725
Brugia malayi MBOAT family protein 0.0282 0.0792 0.0792
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0104 0.0931
Schistosoma mansoni opsin-like receptor 0.0044 0.0059 0.0059
Schistosoma mansoni histamine h1 receptor 0.0044 0.0059 0.0059
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.016 0.0843
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0031 0.0021 0.0111
Schistosoma mansoni cpg binding protein 0.0135 0.0339 0.0338
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0022 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.001 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0034 0.0034
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.001 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0031 0.0021 0.0075
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0361 0.1034 0.1034
Loa Loa (eye worm) TYRA-2 protein 0.0044 0.0059 0.0059
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0282 0.0792 0.0792
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0235 0.2125
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0031 0.0021 0.0075
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0209 0.0567 0.2013
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0058 0.0104 0.0104
Echinococcus granulosus dro:myosuppressin receptor 0.0044 0.0059 0.0059
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0036 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0087 0.0191 0.019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.051 0.1494 0.1494
Brugia malayi putative neuropeptide receptor NPR1 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0141 0.0358 0.0358
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.016 0.1453
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0031 0.0021 0.0111
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0031 0.0031
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0058 0.0104 0.1313
Schistosoma mansoni biogenic amine receptor 0.0044 0.0059 0.0059
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.016 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0068 0.0132 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0068 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0058 0.0104 0.1313
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus granulosus serotonin receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0091 0.0204 0.0204
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.001 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0022 0.0181
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0282 0.0792 0.8627
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0382 0.1098 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0032 0.0022 0.0022
Leishmania major cytochrome p450-like protein 0.0031 0.0021 0.0191
Echinococcus multilocularis snurportin 1 0.0299 0.0845 0.0844
Loa Loa (eye worm) hypothetical protein 0.0297 0.0837 0.0837
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0046 0.0415
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0282 0.0792 0.8627
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0031 0.0021 0.0075
Echinococcus granulosus hypothetical protein 0.0044 0.0059 0.0059
Loa Loa (eye worm) CYP4Cod1 0.0049 0.0075 0.0075
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0031 0.0021 0.0075
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0031 0.0021 0.0075
Leishmania major hypothetical protein, conserved 0.0058 0.0104 0.0947
Schistosoma mansoni hypothetical protein 0.0282 0.0792 0.0792
Brugia malayi nuclear receptor NHR-88 0.0068 0.0132 0.0132
Treponema pallidum alginate O-acetylation protein (algI) 0.0282 0.0792 1
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0125 0.0125
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0044 0.0059 0.0059
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0058 0.0104 0.0104
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.016 0.0843
Leishmania major hypothetical protein, conserved 0.0038 0.0042 0.0385
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0104 0.0931
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0266 0.0266
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0058 0.0104 0.0104
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.0451
Brugia malayi hypothetical protein 0.0087 0.0191 0.019
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0046 0.0946
Schistosoma mansoni hypothetical protein 0.1307 0.3945 0.3946
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0031 0.0021 0.0111
Loa Loa (eye worm) beta-lactamase 0.0147 0.0377 0.0377
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0031 0.0021 0.0111
Echinococcus multilocularis lamin dm0 0.0026 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.001 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.1313
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0235 0.0235
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.056 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0068 0.0132 0.0132
Brugia malayi G-protein coupled receptor 0.0044 0.0059 0.0059
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.037 0.3373
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0032 0.0022 0.008
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0206 0.056 0.0559
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0126 0.0126
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.021 0.057 0.2607
Trichomonas vaginalis myo inositol monophosphatase, putative 0.011 0.0263 0.1184
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.042 0.1216 0.5596
Mycobacterium leprae putative cytochrome p450 0.0031 0.0021 0.0111
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0058 0.0104 0.0104
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0282 0.0792 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.0022 0.0022
Mycobacterium leprae Conserved hypothetical protein 0.0031 0.0021 0.0111
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0047 0.0589
Echinococcus multilocularis serotonin receptor 0.0044 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.001 0.0018
Schistosoma mansoni adenoreceptor 0.0044 0.0059 0.0059
Echinococcus multilocularis dro:myosuppressin receptor 0.0044 0.0059 0.0059
Onchocerca volvulus 0.0044 0.0059 0.0248
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0114 0.0114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Onchocerca volvulus 0.0044 0.0059 0.0248
Schistosoma mansoni cpg binding protein 0.0124 0.0305 0.0305
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0049 0.0075 0.0396
Loa Loa (eye worm) MBOAT family protein 0.0282 0.0792 0.0792
Echinococcus granulosus sex peptide receptor 0.0044 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0792 0.3634
Toxoplasma gondii endonuclease IV APN 0.0093 0.0209 0.2276
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0282 0.0792 0.0792
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0031 0.0021 0.0075
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0209 0.2638
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0382 0.1098 0.5049
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0382 0.1098 0.5049
Trichomonas vaginalis conserved hypothetical protein 0.0323 0.0918 0.4217
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0059 0.0059
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0044 0.0059 0.0059
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0641 0.1897 0.1898
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0068 0.0132 0.0589
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0147 0.0377 0.342
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0282 0.0792 0.0792
Brugia malayi Thioredoxin reductase 0.0092 0.0206 0.0206
Echinococcus multilocularis neuropeptide receptor A26 0.1446 0.4373 0.4373
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0046 0.0045
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0068 0.0132 0.0132
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0154 0.068
Echinococcus granulosus orexin receptor type 2 0.0044 0.0059 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Schistosoma mansoni lamin 0.0026 0.0005 0.0005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.011 0.0263 0.1184
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0068 0.0132 0.0132
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.011 0.0263 0.2859
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.051 0.1494 0.1494
Plasmodium vivax multidomain scavenger receptor, putative 0.0062 0.0114 0.1436
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.0059 0.0059
Schistosoma mansoni opsin-like receptor 0.0044 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0013 0.0029
Brugia malayi G protein-coupled receptor F59B2.13 0.0044 0.0059 0.0059
Echinococcus granulosus mitogen activated protein kinase 0.0101 0.0235 0.0235
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0022 0.0071
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0034 0.0034
Plasmodium falciparum glutathione reductase 0.0092 0.0206 0.26
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0068 0.0132 0.0132
Schistosoma mansoni smad1 5 8 and 0.0025 0.0001 0.0001
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0104 0.0104
Echinococcus multilocularis epidermal growth factor receptor 0.0153 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus granulosus survival motor neuron protein 1 0.0485 0.1415 0.1415
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0282 0.0792 0.0792
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0282 0.0792 0.0792
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.016 0.0843
Echinococcus multilocularis neuropeptide FF receptor 2 0.0044 0.0059 0.0059
Schistosoma mansoni coup transcription factor 0.0068 0.0132 0.0132
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0034 0.0034
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0005 0.0005
Toxoplasma gondii hypothetical protein 0.0282 0.0792 0.8627
Plasmodium falciparum phosphodiesterase delta, putative 0.0058 0.0104 0.1313
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0282 0.0792 0.0792
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0075 0.0154 0.1673
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.0393 0.0393
Mycobacterium tuberculosis Possible penicillin-binding protein 0.094 0.2817 1
Echinococcus multilocularis allatostatin A receptor 0.0044 0.0059 0.0059
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0377 0.0377
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0125 0.0125
Onchocerca volvulus 0.0194 0.0522 0.239
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0154 0.1939
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.016 0.1453
Brugia malayi CXXC zinc finger family protein 0.0124 0.0305 0.0305
Leishmania major glycerol uptake protein, putative 0.0282 0.0792 0.7214
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0154 0.1939
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0382 0.1098 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0058 0.0104 0.0104
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Loa Loa (eye worm) hypothetical protein 0.0093 0.0209 0.0209
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0059 0.0059
Brugia malayi F/Y-rich N-terminus family protein 0.0045 0.0063 0.0063
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0297 0.0837 0.0837
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0031 0.0021 0.0075
Brugia malayi Pre-SET motif family protein 0.0641 0.1897 0.1898
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.064 0.1893 1
Brugia malayi Steroid receptor seven-up type 2 0.0068 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.0209 0.0209
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.021 0.057 0.2607
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0059 0.0059
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.0209 0.1104
Brugia malayi ecdysone receptor 0.0032 0.0022 0.0022
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.021 0.057 0.2607
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0147 0.0377 0.0377
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0058 0.0104 0.2316
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0022 0.0181
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0194 0.0194
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.001 0.0113
Echinococcus granulosus epidermal growth factor receptor 0.0082 0.0177 0.0176
Schistosoma mansoni inositol monophosphatase 0.011 0.0263 0.0262
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0147 0.0377 0.1713
Echinococcus granulosus GPCR family 2 0.0065 0.0125 0.0125
Leishmania major glycosyl hydrolase-like protein 0.0028 0.001 0.0088
Brugia malayi hypothetical protein 0.0044 0.0059 0.0059
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0091 0.0204 0.4233
Loa Loa (eye worm) cytochrome P450 family protein 0.0108 0.0256 0.0256
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0046 0.0241
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.001 0.0088
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0031 0.0021 0.0111
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.019 0.0509 0.1805
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0132 0.0132
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0097 0.0222 0.0998
Trichomonas vaginalis conserved hypothetical protein 0.0323 0.0918 0.4217
Loa Loa (eye worm) hypothetical protein 0.0425 0.1233 0.1233
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0147 0.0377 0.1713
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.0059 0.0059
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.0947
Onchocerca volvulus 0.0032 0.0022 0.008
Loa Loa (eye worm) hypothetical protein 0.0144 0.0366 0.0366
Brugia malayi hypothetical protein 0.0485 0.1415 0.1415
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0001 0.0001
Onchocerca volvulus Huntingtin homolog 0.0369 0.1058 0.4868
Brugia malayi MBOAT family protein 0.0282 0.0792 0.0792
Brugia malayi G-protein coupled receptor 0.0044 0.0059 0.0059
Brugia malayi hypothetical protein 0.0369 0.1058 0.1058
Brugia malayi beta-lactamase family protein 0.0147 0.0377 0.0377
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0002 0.0018
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0236 0.0652 0.0652
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0022 0.0199
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0031 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0147 0.0377 0.3433
Schistosoma mansoni ap endonuclease 0.0039 0.0046 0.0045
Trichomonas vaginalis porcupine, putative 0.0282 0.0792 0.3634
Brugia malayi photoreceptor-specific nuclear receptor 0.0068 0.0132 0.0132
Echinococcus granulosus lamin dm0 0.0026 0.0005 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0001 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0282 0.0792 0.0792
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Leishmania major cAMP-specific phosphodiesterase, putative 0.0058 0.0104 0.0947
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0059 0.0059
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0022 0.0115
Loa Loa (eye worm) hypothetical protein 0.0102 0.0238 0.0238
Brugia malayi hypothetical protein 0.0032 0.0022 0.0022
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0022 0.0181
Trichomonas vaginalis set domain proteins, putative 0.0729 0.2169 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0068 0.0132 0.0132
Onchocerca volvulus 0.0062 0.0114 0.0502
Mycobacterium tuberculosis Conserved protein 0.0147 0.0377 0.1338
Schistosoma mansoni tyrosine kinase 0.0153 0.0394 0.0394
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0044 0.0059 0.0059
Brugia malayi orphan nuclear receptor NR2E1 0.0032 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0122 0.0301 0.03
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0214 0.0214
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0044 0.0059 0.0059
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Echinococcus multilocularis cpg binding protein 0.0135 0.0339 0.0338
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0031 0.0021 0.0075
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0058 0.0104 0.0931
Mycobacterium tuberculosis Conserved protein 0.0147 0.0377 0.1338
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0091 0.0204 0.1078
Brugia malayi Glycosyl hydrolases family 31 protein 0.0075 0.0154 0.0153
Leishmania major hypothetical protein, conserved 0.0058 0.0104 0.0947
Brugia malayi Cytochrome P450 family protein 0.0108 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0101 0.0235 0.2139
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.0059 0.0059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0046 0.0398
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.016 0.1453
Schistosoma mansoni rab6-interacting 0.0062 0.0114 0.0114
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0091 0.0204 0.0724
Echinococcus granulosus cpg binding protein 0.0135 0.0339 0.0338
Schistosoma mansoni tyrosine kinase 0.0049 0.0074 0.0074
Trypanosoma cruzi glycerol uptake protein, putative 0.0282 0.0792 0.7209
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0031 0.0021 0.0111
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0002 0.0022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0046 0.0576
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.01 0.1263
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0044 0.0059 0.0059
Schistosoma mansoni alpha glucosidase 0.0075 0.0154 0.0153
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0126 0.0126
Echinococcus granulosus tar DNA binding protein 0.0066 0.0126 0.0126
Echinococcus multilocularis dnaJ subfamily B 0.1307 0.3945 0.3945
Echinococcus multilocularis muscleblind protein 0.1692 0.5133 0.5132
Echinococcus granulosus g protein coupled receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Brugia malayi TAR-binding protein 0.0066 0.0126 0.0126
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0031 0.0021 0.0111
Loa Loa (eye worm) nuclear receptor NHR-67 0.0032 0.0022 0.0022
Onchocerca volvulus 0.0147 0.0377 0.1719
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0073 0.0306
Leishmania major glycerol uptake protein, putative 0.0282 0.0792 0.7214
Brugia malayi Bromodomain containing protein 0.0163 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0147 0.0377 0.0377
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0282 0.0792 0.0792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0059 0.0059
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0635 0.1879 0.1879
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0059 0.0059
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0235 0.2125
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.001 0.0018
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0129 0.0321 0.0321
Toxoplasma gondii hypothetical protein 0.0049 0.0076 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0068 0.0132 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0068 0.0132 0.0132
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0044 0.0059 0.0059
Brugia malayi hypothetical protein 0.0044 0.0059 0.0059
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0022 0.0238
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0058 0.0104 0.0104
Schistosoma mansoni eyes absent homolog 0.0087 0.0191 0.019
Schistosoma mansoni hypothetical protein 0.0065 0.0125 0.0125
Onchocerca volvulus 0.0088 0.0194 0.0872
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.0132
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0209 0.0567 0.2013
Brugia malayi Cytochrome P450 family protein 0.0049 0.0075 0.0075
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Brugia malayi Smad1 0.0025 0.0001 0.0001
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0058 0.0104 0.0451
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0044 0.0059 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Echinococcus multilocularis neuropeptide receptor 0.0044 0.0059 0.0059
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0147 0.0377 0.342
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Schistosoma mansoni thyroid hormone receptor 0.0068 0.0132 0.0132
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0209 0.0567 0.2013
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Echinococcus granulosus neuropeptide receptor 0.0044 0.0059 0.0059
Schistosoma mansoni retinoic acid receptor RXR 0.0068 0.0132 0.0132
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0046 0.0576
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0049 0.0074 0.0074
Leishmania major hypothetical protein, conserved 0.0031 0.002 0.0181
Brugia malayi AKH receptor 0.0044 0.0059 0.0059
Schistosoma mansoni nuclear receptor 0.0032 0.0022 0.0022
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.001 0.0122
Schistosoma mansoni smad1 5 8 and 0.0025 0.0001 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0001 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0046 0.0181
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.3273 0.9999 0.9999
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0154 0.068
Echinococcus multilocularis lysosomal alpha glucosidase 0.0336 0.0958 0.0958
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0114 0.0114
Echinococcus multilocularis mitogen activated protein kinase 0.0101 0.0235 0.0235
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.0377 0.1338
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0044 0.0059 0.0059
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0214 0.2334
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0126 0.0126
Schistosoma mansoni zinc finger protein 0.0031 0.002 0.002
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0125 0.0125
Brugia malayi Dopamine receptor 0.0044 0.0059 0.0059
Schistosoma mansoni aldehyde dehydrogenase 0.0301 0.0851 0.0851
Onchocerca volvulus 0.0099 0.0228 0.1031
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Schistosoma mansoni zinc finger protein 0.005 0.0079 0.0079
Echinococcus granulosus lysosomal alpha glucosidase 0.0336 0.0958 0.0958
Loa Loa (eye worm) DR-78 0.0032 0.0022 0.0022
Onchocerca volvulus 0.0044 0.0059 0.0248
Brugia malayi MBOAT family protein 0.0282 0.0792 0.0792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Echinococcus granulosus thyroid hormone receptor alpha 0.0032 0.0022 0.0022
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0101 0.0235 0.2139
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0091 0.0204 0.0724
Brugia malayi MH2 domain containing protein 0.0025 0.0001 0.0001
Echinococcus multilocularis survival motor neuron protein 1 0.0485 0.1415 0.1415
Schistosoma mansoni tyrosine kinase 0.0081 0.0174 0.0174
Brugia malayi Serotonin receptor 0.0044 0.0059 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0154 0.068
Schistosoma mansoni tyrosine kinase 0.0081 0.0174 0.0174
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0068 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0044 0.0059 0.0059
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0282 0.0792 0.0792
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0282 0.0792 0.0792
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0181 0.0482 1
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0377 0.3421
Echinococcus granulosus nuclear receptor nhr 48 0.0032 0.0022 0.0022
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.019 0.0509 0.2686
Loa Loa (eye worm) hypothetical protein 0.0077 0.016 0.0159
Entamoeba histolytica myo-inositol monophosphatase, putative 0.011 0.0263 0.3314
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0147 0.0377 0.0377
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0068 0.0132 0.0132
Mycobacterium tuberculosis Probable oxidoreductase 0.0232 0.0639 0.2267
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.0059 0.0059
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0635 0.1879 0.1879
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0053 0.0214
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0266 0.0266
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0046 0.0576
Leishmania major glycerol uptake protein, putative 0.0282 0.0792 0.7214
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0059 0.0059
Schistosoma mansoni tyrosine kinase 0.0081 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0057 0.01 0.01
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0058 0.0104 0.0104
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.016 0.2015
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0058 0.0104 0.0104
Entamoeba histolytica hypothetical protein, conserved 0.0282 0.0792 1
Schistosoma mansoni amine GPCR 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0151 0.039 0.1386
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.0087 0.0087
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0032 0.0022 0.0022
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.0377 0.1338
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0031 0.0021 0.0075
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0044 0.0059 0.0059
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0194 0.0194
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0044 0.0059 0.0248
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0068 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0057 0.01 0.01
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0057 0.0517
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0031 0.0021 0.0111
Echinococcus multilocularis sex peptide receptor 0.0044 0.0059 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0154 0.068
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0031 0.0021 0.0075
Loa Loa (eye worm) bromodomain containing protein 0.004 0.0046 0.0046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0125 0.0125
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0031 0.0021 0.0111
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0042 0.0368
Loa Loa (eye worm) hypothetical protein 0.0077 0.016 0.0159
Brugia malayi hypothetical protein 0.0111 0.0266 0.0266
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0109 0.0258 0.0258
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Echinococcus granulosus neutral alpha glucosidase AB 0.0075 0.0154 0.0153
Loa Loa (eye worm) hypothetical protein 0.0057 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0111 0.0266 0.3359
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0147 0.0377 0.3432
Schistosoma mansoni growth hormone secretagogue receptor 0.0044 0.0059 0.0059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0059 0.0059
Echinococcus granulosus Aminotransferase class III 0.0091 0.0204 0.0204
Entamoeba histolytica vacuolar protein sorting 26 0.0282 0.0792 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.0132
Brugia malayi intermediate filament protein 0.0026 0.0005 0.0005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0022 0.0199
Loa Loa (eye worm) hypothetical protein 0.0058 0.0104 0.0104
Brugia malayi nuclear hormone receptor family member nhr-6 0.0032 0.0022 0.0022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0068 0.0132 0.0132
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0058 0.0104 0.0104
Trichomonas vaginalis hypothetical protein 0.0181 0.0482 0.22
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0058 0.0104 0.0104
Brugia malayi Dopamine receptor protein 1 0.0044 0.0059 0.0059
Brugia malayi nuclear hormone receptor 0.0032 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.0206 0.1861
Brugia malayi Doublecortin family protein 0.0062 0.0114 0.0114
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0073 0.0916
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0181 0.0482 0.2547
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.011 0.0263 0.2376
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0109 0.0258 0.0258
Brugia malayi MAP kinase sur-1 0.0101 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.0947
Schistosoma mansoni amine GPCR 0.0044 0.0059 0.0059
Mycobacterium leprae Probable lipase LipE 0.0147 0.0377 0.1991
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.0377 0.1338
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Mycobacterium ulcerans beta-lactamase 0.0147 0.0377 0.1991
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0282 0.0792 0.0792
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0031 0.0021 0.0111
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.0059 0.0059
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0032 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0088 0.0194 0.0194
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0022 0.0238
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.0377 0.1338
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0091 0.0204 0.1078
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0053 0.0214
Loa Loa (eye worm) hypothetical protein 0.0065 0.0125 0.0125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0147 0.0377 0.0377
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.0377 0.0377
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0001 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0068 0.0132 0.0132
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.056 0.0559
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0125 0.0125
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0022 0.0181
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.051 0.1494 0.1494
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.0867 0.7896
Plasmodium vivax phosphodiesterase gamma, putative 0.0058 0.0104 0.1313
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0147 0.0377 0.3432
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0111 0.0266 0.3359
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0058 0.0104 0.0451
Echinococcus multilocularis nuclear receptor nhr 48 0.0032 0.0022 0.0022
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0058 0.0104 0.0931
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0126 0.0126
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0058 0.0104 0.0931
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0382 0.1098 0.5049
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0034 0.0029 0.0029
Plasmodium falciparum thioredoxin reductase 0.0092 0.0206 0.26
Schistosoma mansoni sterol O-acyltransferase 1 0.0282 0.0792 0.0792
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.0206 0.0206
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0046 0.0045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Trypanosoma cruzi ISWI complex protein 0.0031 0.002 0.0162
Schistosoma mansoni smad 0.0025 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0068 0.0132 0.0132
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0002 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0059 0.0059
Brugia malayi nuclear hormone receptor 0.0068 0.0132 0.0132
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.0087 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.0377 0.3433
Schistosoma mansoni hypothetical protein 0.0065 0.0125 0.0125
Brugia malayi RNA binding protein 0.0066 0.0126 0.0126
Brugia malayi ecdysteroid receptor 0.0068 0.0132 0.0132
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.0393 0.0393
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0282 0.0792 1
Loa Loa (eye worm) hypothetical protein 0.1692 0.5133 0.5133
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0059 0.0059
Brugia malayi nuclear hormone receptor family member odr-7 0.0032 0.0022 0.0022
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.0358 0.0358
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0377 0.1713
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0282 0.0792 0.0792
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus multilocularis smad 0.0025 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0299 0.0845 0.0845
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.016 0.0843
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0031 0.0021 0.0075
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.002
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0382 0.1098 0.5049
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0044 0.0059 0.0059
Loa Loa (eye worm) melatonin receptor type 1A 0.0044 0.0059 0.0059
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0001 0.0001
Echinococcus granulosus neuropeptide receptor 0.0044 0.0059 0.0059
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0022 0.0276
Onchocerca volvulus 0.0124 0.0305 0.1385
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0147 0.0377 0.0377
Echinococcus multilocularis inositol monophosphatase 1 0.011 0.0263 0.0262
Onchocerca volvulus 0.0044 0.0059 0.0248
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0181 0.0482 0.1712
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0049 0.0074 0.0074
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0032 0.0022 0.008
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0181 0.0482 0.6086
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0036 0.0034 0.0034
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0058 0.0104 0.0947
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Brugia malayi beta-lactamase 0.0147 0.0377 0.0377
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0059 0.0059
Toxoplasma gondii hypothetical protein 0.0323 0.0918 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Echinococcus multilocularis geminin 0.0361 0.1034 0.1034
Schistosoma mansoni steroid hormone receptor ad4bp 0.0068 0.0132 0.0132
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0046 0.0045
Brugia malayi Furin-like cysteine rich region family protein 0.0153 0.0394 0.0394
Echinococcus granulosus ornithine aminotransferase 0.0091 0.0204 0.0204
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0038 0.0042 0.0385
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0042 0.0052 0.0052
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0382 0.1098 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.001 0.001
Onchocerca volvulus 0.0108 0.0257 0.1163
Loa Loa (eye worm) Smad1 0.0025 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0068 0.0132 0.0132
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.0059 0.0059
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0058 0.0104 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0104 0.0931
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.016 0.0843
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0232 0.0639 0.2267
Mycobacterium ulcerans aldehyde dehydrogenase 0.0301 0.0851 0.4498
Plasmodium falciparum enoyl-acyl carrier reductase 0.0181 0.0482 0.6086
Brugia malayi RNA, U transporter 1 0.008 0.0169 0.0169
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0058 0.0104 0.0104
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0022 0.0077
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.1313
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0301 0.0851 0.3022
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0282 0.0792 0.0792
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0181 0.0482 0.2547
Brugia malayi hypothetical protein 0.0032 0.0022 0.0022
Plasmodium falciparum LCCL domain-containing protein 0.0062 0.0114 0.1436
Schistosoma mansoni myosin xvIII 0.0044 0.0059 0.0059
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0013 0.0029
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0282 0.0792 0.0792
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.016 0.0843
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0147 0.0377 0.0377
Onchocerca volvulus 0.0044 0.0059 0.0248
Brugia malayi Glycosyl hydrolases family 31 protein 0.0336 0.0958 0.0958
Echinococcus multilocularis sterol O acyltransferase 1 0.0282 0.0792 0.0792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0073 0.0791
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0068 0.0132 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0068 0.0132 0.0132
Echinococcus multilocularis insulin receptor 0.0049 0.0074 0.0074
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0282 0.0792 0.0792
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Echinococcus granulosus microtubule associated protein 2 0.1429 0.4321 0.4322
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0031 0.0021 0.0111
Mycobacterium ulcerans hypothetical protein 0.0077 0.016 0.0843
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0059 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0235 0.1056
Echinococcus granulosus o acyltransferase membrane bound domain 0.0282 0.0792 0.0792
Echinococcus multilocularis 0.0031 0.0021 0.0021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0132 0.033 0.033
Echinococcus granulosus zinc finger protein 0.2991 0.913 0.9132
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.1313
Leishmania major trypanothione reductase 0.0092 0.0206 0.1875
Echinococcus multilocularis RUN 0.0062 0.0114 0.0114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0792 0.3634
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0073 0.0791
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.0321 0.0321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0361 0.1034 0.1034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.051 0.1494 0.1494
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0022 0.0199
Schistosoma mansoni neuropeptide receptor 0.0044 0.0059 0.0059
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0104 0.0451
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0104 0.0451
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0044 0.0059 0.0059
Brugia malayi steroid hormone receptor 0.0068 0.0132 0.0132
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.01 0.0529
Brugia malayi MH2 domain containing protein 0.0025 0.0001 0.0001
Loa Loa (eye worm) TK/EGFR protein kinase 0.0153 0.0394 0.0394
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.1049 0.1049
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.0377 0.0377
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0236 0.0652 0.0652
Echinococcus multilocularis epidermal growth factor receptor 0.0082 0.0177 0.0176
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.042 0.1216 0.5596
Onchocerca volvulus 0.0044 0.0059 0.0248
Echinococcus granulosus intermediate filament protein 0.0026 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0235 0.1056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.051 0.1494 0.1494
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.0867 0.7892
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0126 0.0126
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0301 0.0851 0.7752
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.0132
Schistosoma mansoni cytochrome P450 0.0031 0.0021 0.0021
Brugia malayi nuclear receptor RXR 0.0036 0.0034 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0377 0.1713
Schistosoma mansoni neuropeptide receptor 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.0377 0.1338
Plasmodium falciparum importin beta, putative 0.0028 0.001 0.0131
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0266 0.0742 0.0742
Loa Loa (eye worm) hypothetical protein 0.0062 0.0114 0.0114
Schistosoma mansoni rab6-interacting 0.0062 0.0114 0.0114
Schistosoma mansoni alpha-glucosidase 0.0289 0.0814 0.0814
Schistosoma mansoni neuropeptide receptor 0.0044 0.0059 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0126 0.0126
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0068 0.0132 0.0132
Onchocerca volvulus 0.0062 0.0114 0.0502
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0104 0.0931
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0075 0.0075
Trypanosoma cruzi glycerol uptake protein, putative 0.0282 0.0792 0.7209
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0059 0.0059
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0382 0.1098 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0073 0.0072
Trypanosoma brucei glucosidase, putative 0.0075 0.0154 0.1399
Onchocerca volvulus 0.0147 0.0377 0.1719
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0022 0.0115
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0091 0.0204 0.1078
Schistosoma mansoni tyrosine kinase 0.0082 0.0177 0.0176
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0046 0.0576
Brugia malayi hypothetical protein 0.0044 0.0059 0.0059
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0336 0.0958 0.0958
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0002 0.0025
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.0059 0.0059
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0031 0.0031
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.016 0.0843
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.016 0.0843
Echinococcus granulosus geminin 0.0361 0.1034 0.1034
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0031 0.0021 0.0111
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0382 0.1098 0.1098
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.001 0.0095
Mycobacterium ulcerans lipase LipD 0.0147 0.0377 0.1991
Onchocerca volvulus 0.0122 0.0301 0.1365
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0086 0.0764
Echinococcus multilocularis lamin 0.0026 0.0005 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.009 0.0321
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0382 0.1098 0.5049
Echinococcus granulosus epidermal growth factor receptor 0.0153 0.0394 0.0394
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.051 0.1494 0.1494
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0022 0.0199
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.0867 0.7896
Brugia malayi G protein-coupled receptor 0.0044 0.0059 0.0059
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0031 0.0021 0.0111
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.01 0.0355
Echinococcus granulosus ubiquitin specific protease 41 0.0147 0.0377 0.0377
Giardia lamblia Hypothetical protein 0.0058 0.0104 0.2316
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.0059 0.0059
Brugia malayi neuropeptide F receptor 0.0044 0.0059 0.0059
Brugia malayi RE15519p 0.0044 0.0059 0.0059
Toxoplasma gondii ABC1 family protein 0.0147 0.0377 0.4105
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0068 0.0132 0.0132
Echinococcus granulosus inositol monophosphatase 1 0.011 0.0263 0.0262
Loa Loa (eye worm) hhat protein 0.0282 0.0792 0.0792
Brugia malayi hypothetical protein 0.0062 0.0114 0.0114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.011 0.0263 0.5445
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0047 0.0589
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0068 0.0132 0.0132
Onchocerca volvulus 0.0044 0.0059 0.0248
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0154 0.1383
Loa Loa (eye worm) hypothetical protein 0.0485 0.1415 0.1415
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0046 0.0181
Schistosoma mansoni alpha-glucosidase 0.0289 0.0814 0.0814
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0097 0.0224 0.0224
Schistosoma mansoni inositol monophosphatase 0.011 0.0263 0.0262
Mycobacterium ulcerans endonuclease IV 0.0093 0.0209 0.1104
Trypanosoma cruzi GUP1, putative 0.0282 0.0792 0.7209
Schistosoma mansoni opsin-like receptor 0.0044 0.0059 0.0059
Echinococcus granulosus Polycystic kidney disease protein 0.0062 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0042 0.015
Brugia malayi Serotonin receptor 0.0044 0.0059 0.0059
Echinococcus multilocularis g-protein coupled receptor 0.0044 0.0059 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0031 0.0021 0.0075
Schistosoma mansoni hypothetical protein 0.0065 0.0125 0.0125
Echinococcus multilocularis Polycystic kidney disease protein 0.0062 0.0114 0.0114
Onchocerca volvulus 0.0044 0.0059 0.0248
Echinococcus granulosus FTZ F1 alpha 0.0068 0.0132 0.0132
Leishmania major cytochrome p450-like protein 0.0049 0.0075 0.0683
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0031 0.0021 0.0111
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0034 0.0029 0.0029
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.016 0.2015
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0091 0.0204 0.0204
Echinococcus multilocularis neutral alpha glucosidase AB 0.0075 0.0154 0.0153
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0031 0.0021 0.0173
Plasmodium vivax hypothetical protein, conserved 0.0151 0.039 0.4927
Echinococcus granulosus tumor protein p63 0.0697 0.2068 0.2068
Onchocerca volvulus 0.0044 0.0059 0.0248
Brugia malayi Muscleblind-like protein 0.1692 0.5133 0.5133
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0091 0.0204 0.0724
Onchocerca volvulus Bile acid receptor homolog 0.0068 0.0132 0.0589
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0022 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.009 0.0321
Schistosoma mansoni tyrosine kinase 0.0082 0.0177 0.0176
Trypanosoma brucei ISWI complex protein 0.0031 0.002 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0068 0.0132 0.0132
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0147 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0022
Brugia malayi hypothetical protein 0.0036 0.0034 0.0034
Echinococcus multilocularis neuropeptide receptor 0.0044 0.0059 0.0059
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0301 0.0851 0.0851
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0209 0.2638
Plasmodium vivax hypothetical protein, conserved 0.0147 0.0377 0.4758
Echinococcus granulosus o acyltransferase membrane bound domain 0.0282 0.0792 0.0792
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0053 0.0214
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0042 0.0052 0.0052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0377 0.0377
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0104 0.0451
Leishmania major glycerol uptake protein, putative 0.0282 0.0792 0.7214
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.042 0.1216 0.5596
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.0366 0.0366
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0104 0.1133
Schistosoma mansoni amine GPCR 0.0044 0.0059 0.0059
Schistosoma mansoni polycystin 1-related 0.0062 0.0114 0.0114
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0075 0.0075
Toxoplasma gondii hypothetical protein 0.0151 0.039 0.425
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0091 0.0204 0.0724
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.0132
Echinococcus multilocularis ornithine aminotransferase 0.0091 0.0204 0.0204
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0282 0.0792 0.0792
Echinococcus multilocularis musashi 0.0026 0.0005 0.0005
Onchocerca volvulus 0.0044 0.0059 0.0248
Schistosoma mansoni nuclear receptor nhr-48 0.0032 0.0022 0.0022
Brugia malayi hypothetical protein 0.0044 0.0059 0.0059
Schistosoma mansoni biogenic amine receptor 0.0044 0.0059 0.0059
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0091 0.0204 0.1078
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0032 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0282 0.0792 0.0792
Brugia malayi Nuclear hormone receptor E75 0.0032 0.0022 0.0022

Activities

Activity type Activity value Assay description Source Reference
Potency (ADMET) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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