Detailed information for compound 1447978

Basic information

Technical information
  • TDR Targets ID: 1447978
  • Name: (3-quinoxalin-2-ylphenyl) 4-bromo-3-(diethyls ulfamoyl)benzoate
  • MW: 540.429 | Formula: C25H22BrN3O4S
  • H donors: 0 H acceptors: 5 LogP: 4.85 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(S(=O)(=O)c1cc(ccc1Br)C(=O)Oc1cccc(c1)c1cnc2c(n1)cccc2)CC
  • InChi: 1S/C25H22BrN3O4S/c1-3-29(4-2)34(31,32)24-15-18(12-13-20(24)26)25(30)33-19-9-7-8-17(14-19)23-16-27-21-10-5-6-11-22(21)28-23/h5-16H,3-4H2,1-2H3
  • InChiKey: FDFRWERXSFLOMF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-bromo-3-(diethylsulfamoyl)benzoic acid [3-(2-quinoxalinyl)phenyl] ester
  • 4-bromo-3-(diethylsulfamoyl)benzoic acid (3-quinoxalin-2-ylphenyl) ester
  • Oprea1_696742
  • 3-(2-quinoxalinyl)phenyl 4-bromo-3-[(diethylamino)sulfonyl]benzoate
  • MLS000540791
  • SMR000161902
  • AG-205/12140081
  • ZINC00707336
  • A1910/0080291

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0023 0.0052
Onchocerca volvulus 0.0155 0.0534 0.1859
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0065 0.0099
Echinococcus multilocularis lipoxygenase domain containing protein 0.0166 0.0577 0.0577
Onchocerca volvulus 0.0209 0.0742 0.2601
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.0087 0.0272 0.032
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0027 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0058
Echinococcus granulosus tubulin alpha chain 0.1317 0.5015 0.5911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.005 0.0075
Echinococcus granulosus RUN 0.0166 0.0577 0.068
Loa Loa (eye worm) hypothetical protein 0.0039 0.0089 0.0135
Loa Loa (eye worm) tubulin alpha-2 chain 0.1317 0.5015 0.7601
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0205 0.0311
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0025 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0023 0.0052
Brugia malayi PAS domain containing protein 0.0209 0.0744 0.1127
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0082 0.0253 0.0382
Plasmodium vivax multidomain scavenger receptor, putative 0.0166 0.0577 0.0872
Brugia malayi multidrug resistance protein 3 0.0023 0.0025 0.0038
Schistosoma mansoni tubulin subunit alpha 0.1317 0.5015 0.5911
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0109 0.0358 0.0541
Echinococcus multilocularis tubulin subunit beta 0.1727 0.6597 0.6597
Echinococcus multilocularis Tubulin alpha 1 chain 0.1317 0.5015 0.5015
Brugia malayi hypothetical protein 0.0286 0.1038 0.1574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0307 0.0362
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0431 0.1599 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0096
Echinococcus multilocularis tubulin beta 1 chain 0.1727 0.6597 0.6597
Brugia malayi MH1 domain containing protein 0.0043 0.0103 0.0156
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0054 0.0147 0.0222
Onchocerca volvulus 0.0087 0.0272 0.0927
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.011 0.0363 0.0549
Trypanosoma brucei zeta tubulin, putative 0.0732 0.276 0.4184
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.0053 0.0053
Trichomonas vaginalis guanylate cyclase, putative 0.0054 0.0147 0.0222
Toxoplasma gondii tubulin, putative 0.0029 0.0048 0.0071
Schistosoma mansoni polycystin 1-related 0.0166 0.0577 0.068
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1038 0.1224
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0023 0.0052
Brugia malayi tubulin alpha chain - mouse 0.1317 0.5015 0.7602
Brugia malayi 6-phosphofructokinase 0.0118 0.0393 0.0596
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0482 0.2951
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.0023
Echinococcus granulosus CREB binding protein 0.0125 0.0419 0.0493
Leishmania major beta tubulin 0.1727 0.6597 1
Loa Loa (eye worm) agrin synaptic family protein 0.0062 0.0176 0.0265
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0073 0.011
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0188 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0125 0.019
Echinococcus multilocularis follistatin 0.0062 0.0176 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.0023
Brugia malayi Tubulin gamma chain 0.0986 0.374 0.5669
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0089 0.0135
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0213 0.0759 0.0895
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0054 0.0147 0.0222
Echinococcus multilocularis Tubulin beta 2C chain 0.1727 0.6597 0.6597
Schistosoma mansoni agrin 0.0062 0.0176 0.0207
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0358 0.0543
Echinococcus granulosus regulator of G protein signaling 7 0.0045 0.0112 0.0131
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0023 0.0034
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0178 0.0178
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.025 0.0377
Plasmodium vivax delta tubulin, putative 0.0431 0.1599 0.2421
Leishmania major beta tubulin 0.1727 0.6597 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0011 0.0017
Trichomonas vaginalis tubulin beta chain, putative 0.0526 0.1966 0.298
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0112 0.0169
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0392 0.2358
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0023 0.0052
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0073 0.011
Loa Loa (eye worm) hypothetical protein 0.009 0.0286 0.0433
Echinococcus multilocularis Niemann Pick C1 protein 0.021 0.0747 0.0746
Echinococcus multilocularis beta tubulin 0.1727 0.6597 0.6597
Trichomonas vaginalis tubulin beta chain, putative 0.1317 0.5015 0.7601
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0255 0.03
Brugia malayi hypothetical protein 0.009 0.0286 0.0434
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0117 0.0176
Echinococcus multilocularis lipoxygenase domain containing protein 0.0166 0.0577 0.0577
Plasmodium falciparum tubulin gamma chain 0.0986 0.374 0.5668
Echinococcus granulosus tubulin alpha 3 chain 0.1317 0.5015 0.5911
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0255 0.0254
Brugia malayi bHLH-PAS transcription factor 0.0155 0.0534 0.0809
Echinococcus multilocularis dnaJ subfamily B 0.0872 0.33 0.33
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0103 0.0103
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0099 0.0116
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0178 0.0178
Onchocerca volvulus 0.0748 0.2822 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0258 0.0931 0.5784
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0392 0.2385
Echinococcus multilocularis raf serine:threonine protein kinase 0.0047 0.0118 0.0118
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0125 0.019
Schistosoma mansoni lamin 0.0087 0.0272 0.032
Leishmania major beta tubulin 0.1727 0.6597 1
Echinococcus multilocularis musashi 0.0087 0.0272 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0117
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.0205 0.0242
Echinococcus multilocularis expressed conserved protein 0.0197 0.0698 0.0697
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1053 0.1595
Trichomonas vaginalis abcb9, putative 0.0023 0.0025 0.0037
Brugia malayi nuclear hormone receptor 0.007 0.0205 0.0311
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0055 0.0064
Giardia lamblia Gamma tubulin 0.0986 0.374 0.566
Loa Loa (eye worm) tubulin alpha 2 0.0886 0.3354 0.5083
Schistosoma mansoni Smad4 0.0019 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.014
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.0053 0.0062
Loa Loa (eye worm) hypoxia-induced factor 1 0.0647 0.2433 0.3687
Brugia malayi CXXC zinc finger family protein 0.009 0.0283 0.0429
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0023 0.0025 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.0205 0.0311
Brugia malayi jmjC domain containing protein 0.0017 0.0002 0.0002
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0125 0.019
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0025 0.0029
Brugia malayi hypothetical protein 0.0384 0.1417 0.2148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0117
Brugia malayi MH2 domain containing protein 0.0043 0.0103 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0577 0.0874
Trichomonas vaginalis tubulin alpha chain, putative 0.1727 0.6597 1
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0272 0.0412
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.0053 0.008
Echinococcus granulosus axis inhibition protein axin 0.0045 0.0112 0.0131
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0208 0.0244
Echinococcus granulosus CREB binding protein 0.0033 0.0065 0.0076
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0073 0.011
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Echinococcus multilocularis thioredoxin glutathione reductase 0.0102 0.0329 0.0329
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0205 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.0023
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0067 0.0101
Loa Loa (eye worm) Smad1 0.0043 0.0103 0.0156
Schistosoma mansoni tubulin subunit alpha 0.1317 0.5015 0.5911
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0067 0.0101
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0023 0.0034
Brugia malayi nuclear receptor RXR 0.0039 0.0089 0.0135
Echinococcus granulosus agrin 0.0062 0.0176 0.0206
Schistosoma mansoni hypothetical protein 0.0895 0.3388 0.3994
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Schistosoma mansoni multidrug resistance protein 0.0023 0.0025 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0023 0.0052
Entamoeba histolytica tubulin alpha-1 chain 0.1317 0.5015 0.7596
Loa Loa (eye worm) steroid hormone receptor 0.007 0.0205 0.0311
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0054 0.0147 0.0222
Loa Loa (eye worm) hypothetical protein 0.009 0.0286 0.0433
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0103 0.0156
Echinococcus granulosus neuropeptide receptor A26 0.099 0.3755 0.4425
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.025 0.0378
Mycobacterium tuberculosis Probable dehydrogenase 0.0232 0.0831 0.5154
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0054 0.0147 0.5334
Trypanosoma brucei alpha tubulin, putative 0.0526 0.1966 0.298
Giardia lamblia Beta tubulin 0.1727 0.6597 1
Brugia malayi Pre-SET motif family protein 0.0657 0.2472 0.3748
Loa Loa (eye worm) hypothetical protein 0.0062 0.0176 0.0265
Plasmodium falciparum tubulin beta chain 0.1727 0.6597 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.0358 0.0543
Loa Loa (eye worm) thioredoxin reductase 0.0102 0.0329 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.0205 0.0311
Echinococcus multilocularis regulator of G protein signaling 0.0045 0.0112 0.0111
Echinococcus multilocularis tubulin epsilon chain 0.0986 0.3739 0.3738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0058
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0431 0.1599 0.2423
Trichomonas vaginalis abcb9, putative 0.0023 0.0025 0.0037
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0025 0.0025
Echinococcus granulosus smad 0.0043 0.0103 0.0121
Echinococcus granulosus Regulator of G protein signaling 20 0.0045 0.0112 0.0131
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0176 0.0264
Schistosoma mansoni transcription factor LCR-F1 0.0151 0.052 0.0613
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0073 0.011
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.0205 0.0205
Leishmania major beta tubulin 0.1727 0.6597 1
Trichomonas vaginalis taga, putative 0.0023 0.0025 0.0037
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0067 0.0101
Brugia malayi TAZ zinc finger family protein 0.0202 0.0718 0.1088
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0023 0.0027
Plasmodium vivax tubulin beta chain, putative 0.1727 0.6597 1
Schistosoma mansoni follistatin 0.0062 0.0176 0.0207
Toxoplasma gondii beta-1 tubulin, putative 0.1727 0.6597 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0039 0.0089 0.0135
Brugia malayi jmjC domain containing protein 0.0017 0.0002 0.0002
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0073 0.0108
Plasmodium falciparum alpha tubulin 1 0.1317 0.5015 0.7601
Brugia malayi tailless protein 0.003 0.0053 0.0081
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0023 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.0023
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0089 0.0104
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.006 0.0091
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0103 0.0121
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0392 0.0574
Trypanosoma brucei beta tubulin 0.1727 0.6597 1
Brugia malayi SPARC precursor 0.0062 0.0176 0.0266
Trypanosoma brucei beta tubulin 0.1727 0.6597 1
Echinococcus multilocularis tumor protein p63 0.1427 0.5438 0.5438
Leishmania major protein kinase, putative 0.0055 0.0151 0.0228
Loa Loa (eye worm) raf kinase 0.0047 0.0118 0.0178
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0025 0.0037
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0392 0.0462
Treponema pallidum NADH oxidase 0.0035 0.0073 0.0368
Toxoplasma gondii histone lysine methyltransferase SET1 0.0177 0.0619 0.0937
Echinococcus multilocularis tubulin alpha chain 0.1317 0.5015 0.5015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0016 0.0023
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0125 0.0147
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0073 0.011
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Loa Loa (eye worm) hypothetical protein 0.0046 0.0113 0.0171
Echinococcus multilocularis Tubulin beta 2C chain 0.1727 0.6597 0.6597
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0027 0.0039
Leishmania major gamma-tubulin 0.0986 0.374 0.5669
Schistosoma mansoni microtubule-associated protein tau 0.2217 0.8484 1
Echinococcus granulosus CREB binding protein 0.0033 0.0065 0.0076
Trypanosoma brucei beta tubulin 0.1727 0.6597 1
Schistosoma mansoni regulator of G protein signaling 0.0045 0.0112 0.0132
Entamoeba histolytica hypothetical protein 0.0045 0.0112 0.0147
Plasmodium vivax tubulin gamma chain, putative 0.0986 0.374 0.5668
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1053 0.1595
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0067 0.0099
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0109 0.0358 0.0543
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0178 0.021
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Echinococcus granulosus CREB binding protein 0.0202 0.0718 0.0846
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.0053 0.008
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0025 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0057 0.0158 0.024
Loa Loa (eye worm) hypothetical protein 0.007 0.0205 0.0311
Loa Loa (eye worm) hypothetical protein 0.0209 0.0742 0.1125
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0023 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0118 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0023 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0117
Loa Loa (eye worm) doublecortin family protein 0.0166 0.0577 0.0874
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.006 0.0089
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0151 0.052 0.0613
Plasmodium falciparum multidrug resistance protein 1 0.0023 0.0025 0.0036
Toxoplasma gondii beta-tubulin, putative 0.1727 0.6597 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0205 0.0311
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0109 0.0358 0.0543
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0036 0.0036
Echinococcus granulosus Niemann Pick C1 protein 0.021 0.0747 0.088
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0073 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0098 0.0148
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0089 0.0134
Toxoplasma gondii alpha-tubulin I, putative 0.1317 0.5015 0.7601
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0232 0.0831 0.5137
Echinococcus multilocularis CREB binding protein 0.0033 0.0065 0.0065
Echinococcus granulosus expressed protein 0.0786 0.2966 0.3496
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.1053 0.6553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0058
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.0053 0.0081
Echinococcus multilocularis Tubulin alpha 1 chain 0.1317 0.5015 0.5015
Leishmania major beta tubulin 0.1727 0.6597 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0023 0.0052
Leishmania major cytochrome p450-like protein 0.0022 0.0023 0.0034
Onchocerca volvulus 0.009 0.0283 0.0966
Echinococcus granulosus tubulin alpha 3 chain 0.1317 0.5015 0.5911
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.006 0.0089
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0073 0.0368
Schistosoma mansoni alpha tubulin 0.1317 0.5015 0.5911
Echinococcus multilocularis hypothetical protein 0.1317 0.5015 0.5015
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.0205 0.0242
Leishmania major hypothetical protein, conserved 0.0081 0.025 0.0378
Brugia malayi MH2 domain containing protein 0.0019 0.0011 0.0017
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0103 0.0103
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1053 0.1595
Loa Loa (eye worm) hypothetical protein 0.0062 0.0176 0.0265
Brugia malayi jmjC domain containing protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0701 0.2642 0.4004
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0025 0.0037
Trypanosoma brucei beta tubulin 0.0957 0.3628 0.5499
Schistosoma mansoni CREB-binding protein 2 0.0202 0.0718 0.0846
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0073 0.011
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0384 0.1417 0.2148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0036 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.0205 0.0311
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.006 0.0069
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0208 0.0314
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0307 0.0307
Schistosoma mansoni intermediate filament proteins 0.0087 0.0272 0.032
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.006 0.0091
Schistosoma mansoni z-protein (S1r protein) 0.0045 0.0112 0.0132
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0109 0.0358 0.0543
Toxoplasma gondii protease inhibitor PI2 0.0062 0.0176 0.0264
Schistosoma mansoni smad1 5 8 and 0.0043 0.0103 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0116 0.0136
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0023 0.0025 0.0036
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0011 0.0011
Echinococcus multilocularis mitogen activated protein kinase 3 0.0109 0.0358 0.0358
Onchocerca volvulus 0.0023 0.0025 0.0049
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0067 0.0331
Loa Loa (eye worm) nuclear factor I 0.0024 0.0029 0.0043
Entamoeba histolytica hypothetical protein 0.0151 0.052 0.0768
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0089 0.0135
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.0205 0.0311
Brugia malayi Cell division protein ftsZ 0.0431 0.1599 0.2423
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0631 0.2371 0.3594
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0053 0.0053
Schistosoma mansoni tubulin subunit beta 0.1727 0.6597 0.7776
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0208 0.0245
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0106 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0049 0.0073
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0015 0.0022
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0016 0.0023
Brugia malayi Nuclear hormone receptor E75 0.003 0.0053 0.0081
Onchocerca volvulus Huntingtin homolog 0.0384 0.1417 0.5001
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0067 0.0099
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0045 0.0112 0.0169
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0125 0.0168
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0025 0.0029
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.006 0.0089
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0103 0.0121
Echinococcus multilocularis regulator of G protein signaling 7 0.0045 0.0112 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0057 0.0158 0.0187
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.0199 0.0301
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0392 0.0594
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.006 0.0089
Echinococcus multilocularis protein patched 0.009 0.0285 0.0284
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.0384 0.1417 0.2148
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0358 0.0543
Schistosoma mansoni rab6-interacting 0.0166 0.0577 0.068
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0067 0.0101
Trypanosoma cruzi tubulin gamma chain 0.0986 0.374 0.5669
Trypanosoma cruzi trypanothione reductase, putative 0.0102 0.0329 0.0498
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0045 0.0112 0.0169
Trypanosoma cruzi cytochrome P450, putative 0.0068 0.0199 0.0301
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0073 0.0086
Schistosoma mansoni hypothetical protein 0.0058 0.0162 0.0191
Brugia malayi hypothetical protein 0.0039 0.0089 0.0135
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0125 0.019
Echinococcus multilocularis axis inhibition protein axin 0.0045 0.0112 0.0111
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0073 0.011
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0087 0.0131
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0057 0.0158 0.024
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0089 0.0134
Schistosoma mansoni thyroid hormone receptor 0.007 0.0205 0.0242
Echinococcus granulosus regulator of G protein signaling 7 0.0045 0.0112 0.0131
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.007 0.0205 0.069
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0089 0.0134
Trypanosoma brucei tubulin delta chain 0.0611 0.2294 0.3476
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0039 0.0089 0.0089
Loa Loa (eye worm) tubulin alpha chain 0.1317 0.5015 0.7601
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0077 0.0115
Schistosoma mansoni nuclear hormone receptor 0.003 0.0053 0.0063
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0239 0.0239
Leishmania major beta tubulin 0.1727 0.6597 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0025 0.0037
Echinococcus multilocularis tubulin gamma 1 chain 0.0986 0.374 0.374
Schistosoma mansoni thyroid hormone receptor 0.007 0.0205 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0058
Brugia malayi Tubulin beta chain 0.0526 0.1966 0.2981
Onchocerca volvulus 0.0526 0.1966 0.6955
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.025 0.0377
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0015 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0147 0.0222
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1053 0.1595
Trypanosoma cruzi cytochrome P450, putative 0.0068 0.0199 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0117
Loa Loa (eye worm) hypothetical protein 0.0095 0.0304 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0059 0.009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.0205 0.0311
Brugia malayi A-kinase anchor protein 10, precursor 0.0045 0.0112 0.017
Leishmania major beta tubulin 0.1727 0.6597 1
Trypanosoma brucei alpha tubulin 0.1317 0.5015 0.7601
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0089 0.0112
Onchocerca volvulus Putative organic anion transporter 0.009 0.0286 0.0978
Brugia malayi Smad1 0.0043 0.0103 0.0156
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0002 0.0001
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0106 0.0161
Schistosoma mansoni lipoxygenase 0.0365 0.1344 0.1584
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.1053 0.1577
Brugia malayi regulator of G-protein signaling rgs-7 0.0045 0.0112 0.017
Schistosoma mansoni Smad4 0.0043 0.0103 0.0121
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.0205 0.0242
Echinococcus multilocularis tubulin delta chain 0.0431 0.1599 0.1598
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0147 0.0222
Loa Loa (eye worm) pax transcription factor protein 2 0.0256 0.0924 0.14
Loa Loa (eye worm) hypothetical protein 0.0045 0.0112 0.0169
Schistosoma mansoni aryl hydrocarbon receptor 0.0209 0.0744 0.0876
Leishmania major p-glycoprotein 0.0023 0.0025 0.0037
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0058 0.0067
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0054 0.0147 0.0222
Brugia malayi beta-tubulin, identical 0.1727 0.6597 1
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0392 0.0574
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0027 0.004
Onchocerca volvulus 0.009 0.0286 0.0978
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1317 0.5015 0.7601
Echinococcus multilocularis axis inhibition protein axin 0.0045 0.0112 0.0111
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.0205 0.0242
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0116 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0057 0.0158 0.0158
Loa Loa (eye worm) tubulin beta chain 0.1727 0.6597 1
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0285 0.0431
Echinococcus multilocularis jun protein 0.0263 0.0952 0.0951
Echinococcus multilocularis agrin 0.0062 0.0176 0.0175
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0023 0.0024 0.0028
Leishmania major beta tubulin 0.1727 0.6597 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0057 0.0158 0.0187
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0055 0.0081
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0015 0.0023
Brugia malayi Cytochrome P450 family protein 0.0022 0.0023 0.0035
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0208 0.0315
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.0053 0.0081
Brugia malayi isocitrate dehydrogenase 0.0034 0.0067 0.0102
Echinococcus multilocularis tubulin alpha chain 0.1317 0.5015 0.5015
Trichomonas vaginalis tubulin, putative 0.0526 0.1966 0.298
Loa Loa (eye worm) CYP4Cod1 0.0068 0.0199 0.0301
Loa Loa (eye worm) hypothetical protein 0.007 0.0205 0.0311
Leishmania major beta tubulin 0.1727 0.6597 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0208 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0087 0.0131
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0023 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0205 0.0311
Loa Loa (eye worm) hypothetical protein 0.007 0.0205 0.0311
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0082 0.0253 0.0384
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0073 0.0368
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0054 0.0147 0.0222
Brugia malayi ecdysone receptor 0.003 0.0053 0.0081
Brugia malayi hypothetical protein 0.0052 0.0139 0.0211
Schistosoma mansoni nuclear receptor 0.003 0.0053 0.0063
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.006 0.0091
Brugia malayi Tubulin alpha-2 chain 0.1317 0.5015 0.7602
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0023 0.0052
Brugia malayi hypothetical protein 0.0207 0.0734 0.1112
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0036 0.0052
Brugia malayi glutathione reductase 0.0102 0.0329 0.0499
Loa Loa (eye worm) hypothetical protein 0.009 0.0286 0.0433
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0194 0.0684 0.0806
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0023 0.0025 0.0037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0073 0.011
Loa Loa (eye worm) hypothetical protein 0.007 0.0205 0.0311
Schistosoma mansoni alpha tubulin 0.1317 0.5015 0.5911
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0657 0.2472 0.3747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.0205 0.0311
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0067 0.0101
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0055 0.0083
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0109 0.0358 0.0543
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0002 0.0002
Echinococcus granulosus microtubule associated protein 2 0.2217 0.8484 1
Echinococcus multilocularis geminin 0.0895 0.3388 0.3388
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0392 0.0594
Mycobacterium leprae cell division protein FtsZ 0.0431 0.1599 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0176 0.0264
Echinococcus multilocularis lamin 0.0087 0.0272 0.0272
Brugia malayi Nuclear hormone receptor E75 0.003 0.0053 0.0081
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0055 0.0054
Schistosoma mansoni hypothetical protein 0.0872 0.33 0.389
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Trichomonas vaginalis tubulin gamma chain, putative 0.0431 0.1599 0.2423
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0023 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.0205 0.0242
Brugia malayi nuclear receptor NHR-67 0.003 0.0053 0.0081
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0046 0.0116 0.0175
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0046 0.0116 0.0175
Loa Loa (eye worm) hypothetical protein 0.0042 0.0099 0.0149
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.006 0.0091
Trichomonas vaginalis guanylate cyclase, putative 0.0054 0.0147 0.0222
Brugia malayi hypothetical protein 0.0039 0.0089 0.0135
Brugia malayi Pax transcription factor protein 2 0.0256 0.0924 0.14
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0045 0.0112 0.0169
Echinococcus granulosus organic anion transporting polypeptide 30B 0.009 0.0286 0.0337
Echinococcus multilocularis beta adrenergic receptor kinase 0.0046 0.0116 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0087 0.0131
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0023 0.0052
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0232 0.0831 0.5154
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0055 0.0064
Loa Loa (eye worm) DR-78 0.003 0.0053 0.008
Mycobacterium ulcerans endonuclease IV 0.0082 0.0253 0.1506
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.0053 0.0063
Echinococcus multilocularis Regulator of G protein signaling 20 0.0045 0.0112 0.0111
Trichomonas vaginalis tubulin epsilon chain, putative 0.1727 0.6597 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0073 0.0108
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0087 0.0131
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0023 0.0052
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0089 0.0112
Echinococcus granulosus peroxisome assembly protein 26 0.1317 0.5015 0.5911
Loa Loa (eye worm) hypothetical protein 0.0082 0.0253 0.0383
Entamoeba histolytica tubulin alpha chain, putative 0.1317 0.5015 0.7596
Plasmodium vivax multidrug resistance protein 1, putative 0.0023 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.007 0.0205 0.0311
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0055 0.0083
Entamoeba histolytica hypothetical protein 0.0151 0.052 0.0768
Onchocerca volvulus 0.003 0.0053 0.0149
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0026 0.0039
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.0053 0.0063
Schistosoma mansoni tubulin subunit alpha 0.0431 0.1599 0.1884
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0125 0.019
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0392 0.0594
Schistosoma mansoni hypothetical protein 0.0895 0.3388 0.3994
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1038 0.1038
Trypanosoma cruzi beta tubulin, putative 0.1727 0.6597 1
Echinococcus multilocularis Smad4 0.0043 0.0103 0.0103
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0023 0.0052
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.0053 0.0063
Schistosoma mansoni tubulin subunit beta 0.1727 0.6597 0.7776
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.0053 0.0081
Loa Loa (eye worm) alpha-tubulin 0.1317 0.5015 0.7601
Echinococcus multilocularis Polycystic kidney disease protein 0.0166 0.0577 0.0577
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0116 0.0136
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0025 0.0025
Plasmodium falciparum glutathione reductase 0.0102 0.0329 0.0497
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0025 0.0037
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0611 0.2294 0.3475
Giardia lamblia Beta tubulin 0.1727 0.6597 1
Echinococcus granulosus regulator of G protein signaling 3 0.0045 0.0112 0.0131
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0358 0.0543
Echinococcus granulosus beta-adrenergic receptor kinase 0.0046 0.0116 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1053 0.1595
Brugia malayi nuclear hormone receptor 0.003 0.0053 0.0081
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0023 0.0052
Brugia malayi jmjC domain containing protein 0.0068 0.0198 0.03
Mycobacterium leprae Possible regulatory protein 0.0054 0.0147 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0112 0.0169
Schistosoma mansoni cpg binding protein 0.009 0.0283 0.0333
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.0205 0.0205
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0392 0.2385
Loa Loa (eye worm) hypothetical protein 0.0081 0.025 0.0378
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0073 0.0111
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.1053 0.1577
Brugia malayi hypothetical protein 0.0081 0.025 0.0379
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0023 0.0052
Echinococcus granulosus Solute carrier organic anion transporter family 0.009 0.0286 0.0337
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0023 0.0052
Schistosoma mansoni lipoxygenase 0.0663 0.2495 0.2941
Schistosoma mansoni organic anion transporter 0.009 0.0286 0.0337
Schistosoma mansoni lamin 0.0087 0.0272 0.032
Mycobacterium ulcerans cell division protein FtsZ 0.0431 0.1599 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0125 0.019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0198 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0431 0.1599 0.2423
Echinococcus granulosus Tubulin alpha 1 chain 0.1317 0.5015 0.5911
Entamoeba histolytica hypothetical protein 0.0151 0.052 0.0768
Echinococcus multilocularis mitogen activated protein kinase 0.0109 0.0358 0.0358
Schistosoma mansoni survival motor neuron protein 0.0058 0.0162 0.0191
Echinococcus granulosus Protein patched homolog 1 0.009 0.0285 0.0335
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0482 0.2926
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0025 0.0037
Trypanosoma cruzi epsilon tubulin, putative 0.0986 0.3739 0.5667
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.0205 0.0242
Trichomonas vaginalis tubulin gamma chain, putative 0.0986 0.374 0.5669
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0208 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.0205 0.0311
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0073 0.0368
Echinococcus granulosus Tubulin alpha 1 chain 0.1317 0.5015 0.5911
Echinococcus granulosus geminin 0.0895 0.3388 0.3993
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0258 0.0931 0.5769
Trichomonas vaginalis tubulin alpha chain, putative 0.0526 0.1966 0.298
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0037 0.0056
Mycobacterium ulcerans epimerase 0.0022 0.002 0.0035
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.0205 0.0205
Echinococcus multilocularis tubulin alpha 3 chain 0.1317 0.5015 0.5015
Leishmania major beta tubulin 0.1727 0.6597 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0096 0.0307 0.0465
Trypanosoma cruzi tubulin delta chain 0.0611 0.2294 0.3476
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0392 0.0594
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0025 0.0025
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0067 0.0079
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.0053 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.0023
Brugia malayi PXA domain containing protein 0.0045 0.0112 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0205 0.0242
Loa Loa (eye worm) alpha-tubulin 0.1317 0.5015 0.7601
Trypanosoma cruzi epsilon tubulin, putative 0.0986 0.3739 0.5667
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0025 0.0037
Echinococcus granulosus neuropeptide s receptor 0.099 0.3755 0.4425
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.006 0.0089
Trichomonas vaginalis tubulin gamma chain, putative 0.0986 0.3739 0.5667
Echinococcus granulosus dnaJ subfamily B 0.0872 0.33 0.3889
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0027 0.004
Entamoeba histolytica P-glycoprotein-2 0.0023 0.0025 0.0016
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0202 0.0718 0.0846
Brugia malayi Tubulin alpha-2 chain 0.1317 0.5015 0.7602
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0791 0.2986 0.4526
Echinococcus granulosus tubulin beta 4A class IVa 0.1727 0.6597 0.7776
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.006 0.0287
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0176 0.0266
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0272 0.0412
Onchocerca volvulus Bile acid receptor homolog 0.007 0.0205 0.069
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0089 0.0105
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0027 0.0074
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0089 0.0104
Onchocerca volvulus 0.0054 0.0147 0.0482
Schistosoma mansoni tubulin subunit beta 0.1727 0.6597 0.7776
Echinococcus multilocularis regulator of G protein signaling 3 0.0045 0.0112 0.0111
Leishmania major beta tubulin 0.1727 0.6597 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1053 0.1595
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0307 0.0464
Echinococcus multilocularis regulator of G protein signaling 7 0.0045 0.0112 0.0111
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0023 0.0052
Echinococcus granulosus FTZ F1 alpha 0.007 0.0205 0.0242
Echinococcus granulosus retinoic acid receptor rxr beta a 0.007 0.0205 0.0242
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0037
Echinococcus granulosus lamin dm0 0.0087 0.0272 0.032
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0011 0.0013
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0054 0.0147 0.0146
Loa Loa (eye worm) tubulin beta-2A chain 0.1727 0.6597 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0255 0.03
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0188 0.0282
Giardia lamblia GTOR 0.0049 0.0125 0.0168
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0232 0.0831 0.5154
Trichomonas vaginalis tubulin, putative 0.046 0.1711 0.2593
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0198 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0058
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0285 0.0335
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0307 0.0362
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0023 0.0052
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0392 0.0594
Echinococcus granulosus tubulin alpha chain 0.1317 0.5015 0.5911
Echinococcus granulosus tubulin subunit TubB 0.1317 0.5015 0.5911
Schistosoma mansoni nuclear hormone receptor 0.007 0.0205 0.0242
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0055 0.0081
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0053 0.0062
Echinococcus multilocularis FTZ F1 alpha 0.007 0.0205 0.0205
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0023 0.0025 0.0037
Schistosoma mansoni cytochrome P450 0.0022 0.0023 0.0027
Onchocerca volvulus 0.0087 0.0272 0.0927
Leishmania major epsilon tubulin, putative 0.0986 0.3739 0.5667
Schistosoma mansoni cpg binding protein 0.0095 0.0303 0.0357
Brugia malayi MH2 domain containing protein 0.0631 0.2371 0.3595
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.006 0.0091
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.0205 0.0205
Echinococcus granulosus regulator of G protein signaling 3 0.0045 0.0112 0.0131
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0392 0.0594
Onchocerca volvulus 0.0166 0.0577 0.2012
Loa Loa (eye worm) hypothetical protein 0.0286 0.1038 0.1573
Brugia malayi MH1 domain containing protein 0.0043 0.0103 0.0156
Trichomonas vaginalis tubulin beta chain, putative 0.1317 0.5015 0.7601
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.0023
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0073 0.011
Trypanosoma brucei cytochrome P450, putative 0.0068 0.0199 0.0301
Onchocerca volvulus 0.0062 0.0176 0.0584
Onchocerca volvulus 0.009 0.0286 0.0978
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0017
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0176 0.0265
Echinococcus granulosus phd:f box containing protein 0.0017 0.0002 0.0001
Giardia lamblia Kinase, CMGC MAPK 0.0109 0.0358 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0112 0.0169
Echinococcus multilocularis peroxisome assembly protein 26 0.1317 0.5015 0.5015
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0025 0.0037
Schistosoma mansoni multidrug resistance protein 0.0023 0.0025 0.0029
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0073 0.0108
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0023 0.0052
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0106 0.0106
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0025 0.0029
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0094 0.011
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.0053 0.008
Giardia lamblia Delta tubulin 0.0431 0.1599 0.2406
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0025 0.0025
Leishmania major beta tubulin 0.1727 0.6597 1
Schistosoma mansoni tubulin subunit beta 0.1727 0.6597 0.7776
Loa Loa (eye worm) tubulin gamma chain 0.0986 0.374 0.5669
Echinococcus granulosus Tubulin beta 2C chain 0.1727 0.6597 0.7776
Echinococcus multilocularis beta tubulin 0.1727 0.6597 0.6597
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0045 0.0112 0.0132
Echinococcus multilocularis neuropeptide receptor A26 0.099 0.3755 0.3755
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0886 0.3354 0.5083
Brugia malayi regulator of G-protein signaling egl-10 0.0045 0.0112 0.017
Brugia malayi intermediate filament protein 0.0087 0.0272 0.0412
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0056 0.0085
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0025 0.0037
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0002 0.0002
Trichomonas vaginalis tubulin epsilon chain, putative 0.1727 0.6597 1
Echinococcus multilocularis RUN 0.0166 0.0577 0.0577
Schistosoma mansoni ap endonuclease 0.002 0.0015 0.0017
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.0205 0.0242
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0176 0.0264
Schistosoma mansoni retinoic acid receptor RXR 0.007 0.0205 0.0242
Onchocerca volvulus 0.009 0.0286 0.0978
Brugia malayi nuclear receptor RXR 0.003 0.0053 0.0081
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.0038 0.0056
Brugia malayi Regulator of G protein signaling domain containing protein 0.0045 0.0112 0.017
Echinococcus multilocularis lamin dm0 0.0087 0.0272 0.0272
Echinococcus granulosus tubulin gamma 1 chain 0.0986 0.374 0.4408
Loa Loa (eye worm) hypothetical protein 0.009 0.0286 0.0433
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0482 0.2951
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0073 0.011
Loa Loa (eye worm) multidrug resistance protein 3 0.0023 0.0025 0.0037
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0286 0.0337
Onchocerca volvulus 0.0256 0.0924 0.3245
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Trichomonas vaginalis tubulin beta chain, putative 0.1317 0.5015 0.7601
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0176 0.0264
Mycobacterium ulcerans hypothetical protein 0.0022 0.002 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0058
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.0205 0.0242
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0198 0.03
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0082 0.0253 0.1506
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0039 0.0089 0.0105
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.0205 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.0023
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0109 0.0358 0.0543
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0054 0.0147 0.0222
Brugia malayi hypothetical protein 0.003 0.0053 0.0081
Echinococcus multilocularis Tubulin beta 2C chain 0.1727 0.6597 0.6597
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0272 0.0412
Echinococcus multilocularis Tubulin alpha 1 chain 0.1317 0.5015 0.5015
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0078 0.0091
Trichomonas vaginalis tubulin beta chain, putative 0.1317 0.5015 0.7601
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Trypanosoma brucei epsilon tubulin 0.0986 0.3739 0.5667
Entamoeba histolytica P-glycoprotein-1 0.0023 0.0025 0.0016
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.0205 0.0205
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0089 0.0104
Echinococcus granulosus Tubulin beta 2C chain 0.1727 0.6597 0.7776
Schistosoma mansoni smdr2 0.0023 0.0025 0.0029
Echinococcus granulosus lipoxygenase domain containing protein 0.0166 0.0577 0.068
Echinococcus granulosus tubulin alpha chain 0.1317 0.5015 0.5911
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0023 0.0052
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0023 0.0033
Trypanosoma brucei alpha tubulin 0.1317 0.5015 0.7601
Brugia malayi Tubulin alpha chain 0.1317 0.5015 0.7602
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0307 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.0023
Entamoeba histolytica hypothetical protein 0.0151 0.052 0.0768
Loa Loa (eye worm) hypothetical protein 0.0054 0.0147 0.0222
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0045 0.0112 0.0169
Onchocerca volvulus Putative organic anion transporter 0.009 0.0286 0.0978
Loa Loa (eye worm) hypothetical protein 0.0039 0.0089 0.0135
Schistosoma mansoni hypothetical protein 0.0087 0.0272 0.032
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0103 0.0156
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Schistosoma mansoni tubulin subunit gamma 0.0986 0.374 0.4408
Echinococcus multilocularis tubulin subunit TubB 0.1317 0.5015 0.5015
Loa Loa (eye worm) tubulin beta chain 0.0431 0.1599 0.2423
Schistosoma mansoni smad 0.0043 0.0103 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.005 0.0075
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0087 0.0131
Trichomonas vaginalis set domain proteins, putative 0.0748 0.2822 0.4277
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.002 0.0035
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.0205 0.0311
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0002 0.0002
Schistosoma mansoni zinc finger protein 0.003 0.0053 0.0063
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.006 0.0091
Plasmodium vivax tubulin epsilon chain, putative 0.0986 0.3739 0.5666
Leishmania major zeta tubulin, putative 0.0732 0.276 0.4184
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0094 0.0093
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0073 0.0368
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0027 0.0074
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0073 0.0088
Brugia malayi ABC transporter family protein 0.0023 0.0025 0.0038
Echinococcus multilocularis ATP binding cassette sub family B 0.0023 0.0024 0.0024
Trichomonas vaginalis abcb9, putative 0.0023 0.0025 0.0037
Schistosoma mansoni tubulin subunit beta 0.1727 0.6597 0.7776
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.0205 0.0311
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Loa Loa (eye worm) glutathione reductase 0.0102 0.0329 0.0498
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0176 0.0266
Brugia malayi MH2 domain containing protein 0.0043 0.0103 0.0156
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0015 0.0022
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0089 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0205 0.0205
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0358 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0089 0.0134
Brugia malayi hypothetical protein 0.0701 0.2642 0.4005
Loa Loa (eye worm) hypothetical protein 0.0039 0.0089 0.0135
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0176 0.0266
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.025 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0087 0.0131
Echinococcus multilocularis expressed protein 0.0062 0.0176 0.0175
Echinococcus granulosus Tubulin beta 2C chain 0.1727 0.6597 0.7776
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0067 0.0067
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0023 0.0052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0205 0.0242
Schistosoma mansoni hypothetical protein 0.0151 0.052 0.0613
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0036 0.0036
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0045 0.0112 0.0131
Brugia malayi Steroid receptor seven-up type 2 0.007 0.0205 0.0311
Loa Loa (eye worm) hypothetical protein 0.0045 0.0112 0.0169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.0023
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.021 0.0747 0.1112
Brugia malayi prostaglandin transporter 0.009 0.0286 0.0434
Schistosoma mansoni regulator of G protein signaling 0.0046 0.0116 0.0137
Loa Loa (eye worm) hypothetical protein 0.0791 0.2986 0.4526
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0089 0.0134
Echinococcus granulosus tubulin delta chain 0.0431 0.1599 0.1884
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0392 0.0594
Echinococcus granulosus tubulin alpha 1C chain 0.1317 0.5015 0.5911
Entamoeba histolytica hypothetical protein 0.0045 0.0112 0.0147
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0025 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0073 0.011
Trichomonas vaginalis tubulin epsilon chain, putative 0.0431 0.1599 0.2423
Loa Loa (eye worm) tubulin beta-1 chain 0.1727 0.6597 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0011 0.0017
Brugia malayi hypoxia-induced factor 1 0.0647 0.2433 0.3687
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0663 0.2495 0.2495
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0036 0.0043
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0053 0.0053
Trichomonas vaginalis tubulin epsilon chain, putative 0.1317 0.5015 0.7601
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0089 0.0135
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0214 0.0762 0.0897
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0147 0.0222
Echinococcus multilocularis CREB binding protein 0.0033 0.0065 0.0065
Schistosoma mansoni coup transcription factor 0.007 0.0205 0.0242
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0015 0.0014
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0188 0.0221
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0083
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0045 0.0112 0.0132
Echinococcus granulosus beta tubulin 0.1727 0.6597 0.7776
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0078 0.0077
Loa Loa (eye worm) hypothetical protein 0.0039 0.0089 0.0135
Loa Loa (eye worm) transcription factor SMAD2 0.0631 0.2371 0.3594
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0089 0.0134
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0188 0.1091
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0125 0.019
Brugia malayi conserved hypotetical protein 0.003 0.0053 0.0081
Echinococcus granulosus beta tubulin 0.1727 0.6597 0.7776
Schistosoma mansoni hypothetical protein 0.0087 0.0272 0.032
Loa Loa (eye worm) PXA domain-containing protein 0.0045 0.0112 0.0169
Loa Loa (eye worm) hypothetical protein 0.0062 0.0176 0.0265
Brugia malayi Niemann-Pick C1 protein precursor 0.021 0.0747 0.1132
Plasmodium vivax SET domain protein, putative 0.0096 0.0307 0.0464
Trypanosoma cruzi zeta tubulin, putative 0.0732 0.276 0.4184
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0205 0.0311
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.0358 0.0543
Echinococcus multilocularis Tubulin beta 2C chain 0.1727 0.6597 0.6597
Echinococcus granulosus Tubulin alpha 1 chain 0.1317 0.5015 0.5911
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.0205 0.0242
Echinococcus multilocularis tubulin alpha 0.0957 0.3628 0.3627
Loa Loa (eye worm) hypothetical protein 0.0166 0.0577 0.0874
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0054 0.0147 0.0222
Brugia malayi Cytochrome P450 family protein 0.0068 0.0199 0.0302
Echinococcus multilocularis CREB binding protein 0.0033 0.0065 0.0065
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.006 0.0091
Plasmodium falciparum LCCL domain-containing protein 0.0166 0.0577 0.0872
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Schistosoma mansoni patched 1 0.009 0.0285 0.0335
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0023 0.0052
Echinococcus multilocularis tubulin alpha chain 0.1317 0.5015 0.5015
Plasmodium vivax glutathione reductase, putative 0.0102 0.0329 0.0497
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0392 0.0462
Loa Loa (eye worm) tubulin alpha-3 chain 0.0791 0.2986 0.4526
Echinococcus multilocularis tubulin alpha 1C chain 0.1317 0.5015 0.5015
Trichomonas vaginalis adenylate cyclase, putative 0.0054 0.0147 0.0222
Schistosoma mansoni DNA helicase recq1 0.003 0.0055 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0205 0.0242
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0089 0.0088
Echinococcus granulosus intermediate filament protein 0.0087 0.0272 0.032
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Entamoeba histolytica hypothetical protein 0.0023 0.0027 0.0018
Loa Loa (eye worm) sodium-independent organic anion transporter 0.009 0.0286 0.0433
Onchocerca volvulus 0.003 0.0053 0.0149
Loa Loa (eye worm) RecQ helicase 0.0044 0.0106 0.0161
Echinococcus granulosus Tubulin beta 2C chain 0.1727 0.6597 0.7776
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0067 0.0067
Trypanosoma brucei trypanothione reductase 0.0102 0.0329 0.0498
Echinococcus granulosus alpha tubulin 0.1317 0.5015 0.5911
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0198 0.0233
Echinococcus granulosus jun protein 0.0263 0.0952 0.1121
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0025 0.0037
Schistosoma mansoni regulator of G protein signaling 0.0045 0.0112 0.0132
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0392 0.0594
Loa Loa (eye worm) hypothetical protein 0.0062 0.0176 0.0265
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0023 0.0052
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0025 0.0037
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0023 0.0034
Loa Loa (eye worm) tubulin alpha chain 0.1317 0.5015 0.7601
Echinococcus multilocularis protein dispatched 1 0.0103 0.0334 0.0333
Schistosoma mansoni hypothetical protein 0.0022 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.003
Schistosoma mansoni cellular tumor antigen P53 0.0209 0.0742 0.0875
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0023 0.0052
Onchocerca volvulus 0.0207 0.0734 0.257
Loa Loa (eye worm) hypothetical protein 0.009 0.0286 0.0433
Brugia malayi MAP kinase sur-1 0.0109 0.0358 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.0023
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0025 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0117
Entamoeba histolytica tubulin family protein 0.1727 0.6597 1
Brugia malayi hypothetical protein 0.0045 0.0112 0.017
Schistosoma mansoni Smad4 0.0019 0.0011 0.0013
Trypanosoma cruzi MFS transporter, putative 0.009 0.0286 0.0433
Echinococcus granulosus tubulin epsilon chain 0.0986 0.3739 0.4406
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0392 0.2385
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0188 0.0221
Echinococcus granulosus raf serine:threonine protein kinase 0.0047 0.0118 0.0139
Loa Loa (eye worm) RGS-3 protein 0.0045 0.0112 0.0169
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0023 0.0052
Echinococcus granulosus mitogen activated protein kinase 0.0109 0.0358 0.0422
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.0283 0.0428
Brugia malayi hypothetical protein 0.0166 0.0577 0.0875
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0082 0.0255 0.0385
Echinococcus multilocularis aryl hydrocarbon receptor 0.0054 0.0147 0.0146
Schistosoma mansoni smad1 5 8 and 0.0043 0.0103 0.0121
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.0205 0.0242
Trichomonas vaginalis DNA helicase recq, putative 0.0033 0.0065 0.0099
Echinococcus multilocularis Solute carrier organic anion transporter family 0.009 0.0286 0.0286
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0055 0.0151 0.0228
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0023 0.0052
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0067 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1053 0.1595
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0055 0.0151 0.0228
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0055 0.0151 0.0228
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0015 0.0022
Brugia malayi hypothetical protein 0.0151 0.052 0.0788
Trypanosoma brucei protein kinase, putative 0.0109 0.0358 0.0543
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0023 0.0052
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.0199 0.0301
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0023 0.0052
Plasmodium vivax tubulin alpha chain, putative 0.1317 0.5015 0.7601
Schistosoma mansoni tubulin subunit beta 0.1727 0.6597 0.7776
Schistosoma mansoni hypothetical protein 0.0087 0.0272 0.032
Leishmania major beta tubulin 0.1727 0.6597 1
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0058 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.0205 0.0311
Echinococcus multilocularis transfer RNA-Lys 0.0155 0.0534 0.0534
Onchocerca volvulus Putative organic anion transporter 0.009 0.0286 0.0978
Mycobacterium tuberculosis Cell division protein FtsZ 0.0431 0.1599 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0002 0.0002
Plasmodium vivax tubulin alpha chain, putative 0.1317 0.5015 0.7601
Loa Loa (eye worm) hypothetical protein 0.0085 0.0266 0.0402
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0039 0.0089 0.0105
Echinococcus granulosus Smad4 0.0043 0.0103 0.0121
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0089 0.0134
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.0023
Leishmania major beta tubulin 0.1727 0.6597 1
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0082 0.0253 0.0382
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0125 0.0148
Schistosoma mansoni tubulin subunit alpha 0.1317 0.5015 0.5911
Brugia malayi follicle stimulating hormone receptor 0.0258 0.093 0.141
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0125 0.019
Echinococcus granulosus tubulin alpha chain 0.1317 0.5015 0.5911
Brugia malayi Regulator of G protein signaling domain containing protein 0.0045 0.0112 0.017
Brugia malayi secreted modular calcium-binding protein 1 0.0062 0.0176 0.0266
Trichomonas vaginalis tubulin, putative 0.0526 0.1966 0.298
Entamoeba histolytica P-glyco protein 6, putative 0.0023 0.0025 0.0016
Chlamydia trachomatis endonuclease IV 0.0082 0.0253 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0112 0.0169
Loa Loa (eye worm) BEN-1 protein 0.1727 0.6597 1
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.006 0.0089
Brugia malayi sodium-independent organic anion transporter family protein 0.009 0.0286 0.0434
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0125 0.0168
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0106 0.0161
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0025 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0358 0.0422
Onchocerca volvulus 0.0082 0.0255 0.0865
Echinococcus granulosus single minded 2 0.0155 0.0534 0.0629
Loa Loa (eye worm) BEN-1 protein 0.1727 0.6597 1
Schistosoma mansoni axis inhibition protein axin 0.0045 0.0112 0.0132
Plasmodium vivax thioredoxin reductase, putative 0.0102 0.0329 0.0497
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.006 0.0069
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0526 0.1966 0.298
Echinococcus granulosus axis inhibition protein axin 0.0045 0.0112 0.0131
Trichomonas vaginalis tubulin, putative 0.1727 0.6597 1
Brugia malayi Pre-SET motif family protein 0.0096 0.0307 0.0466
Trypanosoma brucei tubulin gamma chain 0.0986 0.374 0.5669
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0037
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0043
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0067 0.0101
Toxoplasma gondii thioredoxin reductase 0.0102 0.0329 0.0497
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0073 0.011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0015 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0053 0.0062
Trypanosoma brucei epsilon tubulin 0.0957 0.3628 0.5499
Plasmodium falciparum thioredoxin reductase 0.0102 0.0329 0.0497
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0055 0.0083
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0067 0.0067
Mycobacterium ulcerans putative regulatory protein 0.0155 0.0534 0.3278
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0002 0.0001
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0073 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0045 0.0112 0.0132
Loa Loa (eye worm) hypothetical protein 0.009 0.0286 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0125 0.019
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0027 0.0074
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0089 0.0104
Brugia malayi bZIP transcription factor family protein 0.0263 0.0952 0.1442
Echinococcus granulosus tubulin beta 1 chain 0.1727 0.6597 0.7776
Echinococcus multilocularis expressed protein 0.0786 0.2966 0.2966
Toxoplasma gondii endonuclease IV APN 0.0082 0.0253 0.0382
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0002 0.0002
Schistosoma mansoni nuclear hormone receptor 0.003 0.0053 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1053 0.1595
Echinococcus granulosus mitogen activated protein kinase 3 0.0109 0.0358 0.0422
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0055 0.0081
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0208 0.0207
Brugia malayi sodium-independent organic anion transporter family protein 0.009 0.0286 0.0434
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0023 0.0052
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0027 0.0074
Echinococcus granulosus cpg binding protein 0.0095 0.0303 0.0356
Loa Loa (eye worm) hypothetical protein 0.0087 0.0272 0.0412
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Onchocerca volvulus 0.009 0.0286 0.0978
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0205 0.0311
Trypanosoma cruzi tubulin delta chain 0.0611 0.2294 0.3476
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0045 0.0112 0.0111
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0285 0.0284
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0002 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0205 0.0311
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0065 0.0099
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0015 0.0022
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0027 0.0063
Trichomonas vaginalis tubulin alpha chain, putative 0.0526 0.1966 0.298
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.0205 0.0242
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.006 0.1541
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0205 0.0311
Echinococcus multilocularis Tubulin beta 2C chain 0.1727 0.6597 0.6597
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.025 0.0377
Entamoeba histolytica hypothetical protein 0.0045 0.0112 0.0147
Brugia malayi cytochrome P450 0.0022 0.0023 0.0035
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0232 0.0831 0.5154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0057 0.0158 0.0186
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0057 0.0158 0.0158
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0307 0.0362
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.025 0.0378
Brugia malayi nuclear receptor NHR-88 0.003 0.0053 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0073 0.011
Brugia malayi MH1 domain containing protein 0.0024 0.0029 0.0044
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0027 0.0074
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Entamoeba histolytica P-glycoprotein 5, putative 0.0023 0.0025 0.0016
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0045 0.0112 0.0132
Brugia malayi Tubulin beta-1 chain 0.1727 0.6597 1
Brugia malayi hypothetical protein 0.009 0.0286 0.0434
Echinococcus granulosus tubulin alpha chain 0.1317 0.5015 0.5911
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0112 0.0169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.0023
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0025 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.005 0.0075
Plasmodium falciparum thioredoxin reductase 0.0035 0.0073 0.0108
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.046 0.171 0.2589
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0392 0.0462
Giardia lamblia Beta tubulin 0.1727 0.6597 1
Brugia malayi sodium-independent organic anion transporter family protein 0.009 0.0286 0.0434
Echinococcus multilocularis neuropeptide s receptor 0.099 0.3755 0.3755
Trichomonas vaginalis tubulin beta chain, putative 0.1317 0.5015 0.7601
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0263 0.0952 0.0951
Echinococcus granulosus Tubulin beta 2C chain 0.1727 0.6597 0.7776
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0002 0.0001
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0054 0.0147 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0112 0.0169
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0109 0.0358 0.0543
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0239 0.0281
Brugia malayi hypothetical protein 0.003 0.0053 0.0081
Schistosoma mansoni DNA helicase recq5 0.003 0.0055 0.0064
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0047 0.0055
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0082 0.0253 0.1476
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0023 0.0052
Brugia malayi hypothetical protein 0.0045 0.0112 0.017
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0011 0.0017
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0188 0.0284
Brugia malayi PXA domain containing protein 0.0045 0.0112 0.017
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0045 0.0112 0.0169
Entamoeba histolytica P-glycoprotein-2 0.0023 0.0025 0.0016
Brugia malayi nuclear receptor NHR-88 0.007 0.0205 0.0311
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0025 0.0029
Brugia malayi jmjC domain containing protein 0.0063 0.0178 0.027
Schistosoma mansoni organic anion transporter 0.009 0.0286 0.0337
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0002 0.0001
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.0053 0.0062
Brugia malayi MH1 domain containing protein 0.0024 0.0029 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0023 0.0052
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0089 0.0134
Entamoeba histolytica P-glycoprotein-5 0.0023 0.0025 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0067 0.0067
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.0205 0.069
Schistosoma mansoni ap endonuclease 0.002 0.0015 0.0017
Onchocerca volvulus 0.0058 0.0162 0.0535
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.0023
Trichomonas vaginalis tubulin epsilon chain, putative 0.1317 0.5015 0.7601
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.006 0.0089
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0054 0.0147 0.0222
Brugia malayi tubulin alpha-2 chain 0.1317 0.5015 0.7602
Schistosoma mansoni hypothetical protein 0.0166 0.0577 0.068
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0208 0.0314
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Trichomonas vaginalis helicase, putative 0.002 0.0016 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.0205 0.0311
Schistosoma mansoni rab6-interacting 0.0166 0.0577 0.068
Loa Loa (eye worm) tubulin alpha 2 0.036 0.1324 0.2007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0057 0.0158 0.0186
Loa Loa (eye worm) hypothetical protein 0.1317 0.5015 0.7601
Brugia malayi Cytochrome P450 family protein 0.0068 0.0199 0.0302
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0151 0.052 0.052
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0307 0.0307
Schistosoma mansoni multidrug resistance protein 0.0023 0.0025 0.0029
Echinococcus multilocularis tubulin alpha chain 0.1317 0.5015 0.5015
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0021 0.0025
Schistosoma mansoni jun-related protein 0.0214 0.0762 0.0897
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0025 0.0037
Trypanosoma cruzi zeta tubulin, putative 0.0732 0.276 0.4184
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0176 0.0266
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0117 0.0177
Leishmania major beta tubulin 0.1727 0.6597 1
Schistosoma mansoni alpha tubulin 0.1317 0.5015 0.5911
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0392 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.0023
Entamoeba histolytica recQ family helicase, putative 0.0033 0.0065 0.0077
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.0205 0.0311
Echinococcus granulosus expressed conserved protein 0.0197 0.0698 0.0822
Plasmodium falciparum tubulin delta chain, putative 0.0431 0.1599 0.2421
Brugia malayi Cytochrome P450 family protein 0.0022 0.0023 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0188 0.1091
Leishmania major delta tubulin, putative 0.0611 0.2294 0.3476
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0089 0.0104
Trichomonas vaginalis tubulin beta chain, putative 0.1727 0.6597 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0258 0.093 0.141
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.0205 0.0242
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0208 0.0314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0057 0.0158 0.0187
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0002 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0073 0.011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0 0.0001
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0255 0.0386
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0025 0.0037
Echinococcus granulosus thioredoxin glutathione reductase 0.0102 0.0329 0.0387
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0188 0.0187
Echinococcus granulosus lamin 0.0087 0.0272 0.032
Trichomonas vaginalis tubulin beta chain, putative 0.1317 0.5015 0.7601
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0055 0.0151 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0117
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0023 0.0052
Trypanosoma brucei epsilon tubulin 0.0986 0.3739 0.5667
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0055 0.0061
Brugia malayi phosphofructokinase 0.0118 0.0392 0.0595
Leishmania major beta tubulin 0.1727 0.6597 1
Echinococcus multilocularis tubulin alpha 3 chain 0.1317 0.5015 0.5015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0117
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0073
Leishmania major protein kinase, putative 0.0055 0.0151 0.0228
Entamoeba histolytica tubulin family protein 0.1727 0.6597 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0089 0.0088
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0102 0.0329 0.1984
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0205 0.0311
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0023 0.0017
Brugia malayi alpha-tubulin 0.1317 0.5015 0.7602
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0392 0.0574
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0011 0.0013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0015 0.0022
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0023 0.0052
Loa Loa (eye worm) hypothetical protein 0.009 0.0285 0.0431
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0073 0.011
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0025 0.0037
Brugia malayi 6-phosphofructokinase 0.0118 0.0392 0.0595
Mycobacterium tuberculosis Probable oxidoreductase 0.0258 0.0931 0.5784
Loa Loa (eye worm) CBP-B 0.0141 0.048 0.0726
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0256 0.0924 0.14
Echinococcus granulosus tumor protein p63 0.1427 0.5438 0.641
Schistosoma mansoni smad 0.0019 0.0011 0.0013
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0073 0.0086
Echinococcus granulosus tubulin alpha 1C chain 0.1317 0.5015 0.5911
Echinococcus granulosus tubulin subunit beta 0.1727 0.6597 0.7776
Brugia malayi Tubulin alpha chain 0.0431 0.1599 0.2423
Echinococcus multilocularis CREB binding protein 0.0139 0.0473 0.0472
Leishmania major alpha tubulin 0.1317 0.5015 0.7601
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0073 0.0368
Schistosoma mansoni single-minded 0.0209 0.0744 0.0876
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0073 0.0073
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.006 0.1541
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0263 0.0952 0.1121
Trypanosoma brucei beta tubulin 0.1727 0.6597 1
Mycobacterium tuberculosis Probable reductase 0.0232 0.0831 0.5154
Plasmodium falciparum glutathione reductase 0.0035 0.0073 0.0108
Entamoeba histolytica P-glycoprotein-2, putative 0.0023 0.0025 0.0016
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0054 0.0147 0.0222
Brugia malayi hypothetical protein 0.0166 0.0577 0.0875
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0232 0.0831 0.5154
Echinococcus multilocularis regulator of G protein signaling 3 0.0045 0.0112 0.0111
Leishmania major beta tubulin 0.1727 0.6597 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0258 0.0931 0.5784
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0087 0.0131
Trypanosoma brucei alpha tubulin 0.1317 0.5015 0.7601
Trypanosoma brucei zeta tubulin 0.0732 0.276 0.4184
Brugia malayi Raf kinase 0.0047 0.0118 0.0179
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0208 0.0314
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0053 0.0053
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0067 0.0079
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0023 0.0052
Giardia lamblia Alpha-tubulin 0.1317 0.5015 0.7596
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0073 0.0108
Leishmania major beta tubulin 0.1727 0.6597 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0046 0.0116 0.0175
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0103 0.0121
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0285 0.0431
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0023 0.0025 0.0037
Echinococcus multilocularis 0.0022 0.0023 0.0023
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0023 0.0025 0.0037
Leishmania major cytochrome p450-like protein 0.0068 0.0199 0.0301
Echinococcus granulosus tubulin alpha 0.0957 0.3628 0.4276
Schistosoma mansoni hypothetical protein 0.0273 0.0989 0.1166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0049 0.0073
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0027 0.0038
Echinococcus multilocularis Niemann Pick C1 protein 0.03 0.1094 0.1094
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Trichomonas vaginalis tubulin gamma chain, putative 0.1727 0.6597 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.0205 0.0311
Giardia lamblia Alpha-tubulin 0.1317 0.5015 0.7596
Schistosoma mansoni cpg binding protein 0.0095 0.0303 0.0357
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.002 0.0035
Loa Loa (eye worm) hypothetical protein 0.021 0.0747 0.1131
Schistosoma mansoni axis inhibition protein axin 0.0045 0.0112 0.0132
Echinococcus multilocularis tubulin alpha chain 0.1317 0.5015 0.5015
Brugia malayi jmjC domain containing protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0886 0.3354 0.5083
Schistosoma mansoni hypothetical protein 0.0036 0.0078 0.0091
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0096 0.0143
Brugia malayi Doublecortin family protein 0.0166 0.0577 0.0875
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0073 0.0368
Leishmania major cytochrome p450-like protein 0.0022 0.0023 0.0034
Loa Loa (eye worm) cytochrome P450 0.0022 0.0023 0.0034
Echinococcus granulosus lipoxygenase domain containing protein 0.0166 0.0577 0.068
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0002 0.0001
Brugia malayi ecdysteroid receptor 0.007 0.0205 0.0311
Trichomonas vaginalis tubulin alpha chain, putative 0.0526 0.1966 0.298
Echinococcus multilocularis smad 0.0043 0.0103 0.0103
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0015 0.002
Toxoplasma gondii alpha tubulin TUBA1 0.1317 0.5015 0.7601
Echinococcus multilocularis cpg binding protein 0.0095 0.0303 0.0302
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0065 0.0099
Schistosoma mansoni loxhd1 0.0166 0.0577 0.068
Onchocerca volvulus Huntingtin homolog 0.0384 0.1417 0.5001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0089 0.0135
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0023 0.0052
Schistosoma mansoni smad1 5 8 and 0.0043 0.0103 0.0121
Brugia malayi Tubulin beta chain 0.0431 0.1599 0.2423
Onchocerca volvulus 0.009 0.0286 0.0978
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0178 0.021
Echinococcus granulosus Niemann Pick C1 protein 0.03 0.1094 0.1289
Trypanosoma brucei alpha tubulin 0.1317 0.5015 0.7601
Brugia malayi steroid hormone receptor 0.007 0.0205 0.0311
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0073 0.011
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0073 0.2102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0015 0.0017
Echinococcus granulosus Polycystic kidney disease protein 0.0166 0.0577 0.068
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0053 0.0062
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0021 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0392 0.0594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.0205 0.0311
Schistosoma mansoni tubulin subunit beta 0.0431 0.1599 0.1884
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0068 0.0199 0.1164
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.0053 0.0081
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.025 0.0377
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.002 0.0032
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.0053 0.0053
Trypanosoma cruzi alpha tubulin, putative 0.1317 0.5015 0.7601
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0025 0.0037
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0125 0.0125
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0188 0.1091
Loa Loa (eye worm) hypothetical protein 0.007 0.0205 0.0311
Schistosoma mansoni regulator of G protein signaling 0.0045 0.0112 0.0132
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0067 0.0102
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0067 0.0099
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0023 0.0052
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0015 0.0022
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0392 0.0594
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0096 0.0307 0.0362
Plasmodium falciparum tubulin epsilon chain, putative 0.0986 0.3739 0.5666
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0663 0.2495 0.2941
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0067 0.0099
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.1053 0.1577
Giardia lamblia Epsilon tubulin 0.046 0.171 0.2575
Mycobacterium leprae putative cytochrome p450 0.0022 0.0023 0.0017
Schistosoma mansoni tubulin subunit epsilon 0.0986 0.3739 0.4406
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0002 0.0002
Toxoplasma gondii beta tubulin 0.1727 0.6597 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0957 0.3628 0.5498
Brugia malayi Thioredoxin reductase 0.0102 0.0329 0.0499
Echinococcus multilocularis tubulin alpha 1C chain 0.1317 0.5015 0.5015
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0053 0.0149
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0125 0.019
Leishmania major trypanothione reductase 0.0102 0.0329 0.0498
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1727 0.6597 0.6597
Toxoplasma gondii exonuclease III APE 0.002 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0058 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0431 0.1599 0.2423
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.009 0.0286 0.0286
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0023 0.0025 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0087 0.0131
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0025 0.0029
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0036 0.0043
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0002 0.0002
Echinococcus multilocularis microtubule associated protein 2 0.2217 0.8484 0.8484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0125 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0073 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0036
Entamoeba histolytica tubulin gamma chain 0.0986 0.374 0.566
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0025 0.0037
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0073 0.011
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0188 0.1091
Loa Loa (eye worm) hypothetical protein 0.0045 0.0112 0.0169
Schistosoma mansoni nuclear receptor 0.003 0.0053 0.0063
Brugia malayi CHE-14 protein 0.009 0.0285 0.0431
Treponema pallidum cell division protein FtsZ 0.0431 0.1599 1
Onchocerca volvulus 0.0166 0.0577 0.2012
Plasmodium falciparum alpha tubulin 2 0.1317 0.5015 0.7601
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0162 0.0245
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0002 0.0001
Toxoplasma gondii transporter, major facilitator family protein 0.009 0.0286 0.0432
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0002 0.0002
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0053 0.0149
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0027 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0058
Schistosoma mansoni tubulin subunit delta 0.0431 0.1599 0.1884
Onchocerca volvulus 0.007 0.0205 0.069
Loa Loa (eye worm) tubulin beta-4 chain 0.1727 0.6597 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0023 0.0052
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0023 0.0052
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0023 0.0034
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0023 0.0052
Echinococcus granulosus aryl hydrocarbon receptor 0.0054 0.0147 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.0205 0.0311
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0011 0.0011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0073 0.011
Onchocerca volvulus 0.0096 0.0307 0.1053
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.002 0.0031
Loa Loa (eye worm) beta-tubulin 0.1727 0.6597 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.009 0.0286 0.0433
Loa Loa (eye worm) hypothetical protein 0.0886 0.3354 0.5083
Echinococcus granulosus bloom syndrome protein 0.0044 0.0106 0.0125
Trichomonas vaginalis tubulin alpha chain, putative 0.0957 0.3628 0.5499
Loa Loa (eye worm) tubulin alpha 2 0.0886 0.3354 0.5083
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0023 0.0034
Echinococcus granulosus follistatin 0.0062 0.0176 0.0206

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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