Detailed view for EmuJ_000095900

Basic information

TDR Targets ID: 958000
Echinococcus multilocularis, lysine specific histone demethylase 1A
Source Database / ID:  GeneDB

pI: 5.0673 | Length (AA): 1040 | MW (Da): 113208 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01593   Flavin containing amine oxidoreductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0003677   DNA binding  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 58 4ylf (A) 208 256 6.00 0.022 0 0.168615 -0.87
133 1013 2dw4 (A) 175 831 34.00 0 1 0.693615 1.68
301 352 4gdp (A) 10 63 58.00 0.0019 0.76 0.4837 1.44
301 340 3qj4 (A) 3 45 35.00 0 0.19 0.156662 1.59
467 571 2mqa (A) 24 128 16.00 0 0.19 0.295162 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130448)

Species Accession Gene Product
Arabidopsis thaliana AT4G16310   protein LSD1-like 3
Brugia malayi Bm1_20500   SWIRM domain containing protein
Caenorhabditis elegans CELE_T08D10.2   Protein LSD-1
Caenorhabditis elegans CELE_Y40B1B.6   Protein SPR-5
Drosophila melanogaster Dmel_CG17149   Suppressor of variegation 3-3
Echinococcus granulosus EgrG_000095900   lysine specific histone demethylase 1A
Echinococcus multilocularis EmuJ_000095900   lysine specific histone demethylase 1A
Homo sapiens ENSG00000004487   lysine (K)-specific demethylase 1A
Loa Loa (eye worm) LOAG_09223   hypothetical protein
Loa Loa (eye worm) LOAG_13424   hypothetical protein
Loa Loa (eye worm) LOAG_07849   hypothetical protein
Mus musculus ENSMUSG00000036940   lysine (K)-specific demethylase 1A
Oryza sativa 4349214   Os10g0532100
Onchocerca volvulus OVOC180  
Schistosoma japonicum Sjp_0102670   ko:K00540 amine oxidase (flavin containing) domain 2 [EC:1.-.-.-], putative
Schistosoma japonicum Sjp_0082330   Lysine-specific histone demethylase 1, putative
Schistosoma mansoni Smp_150560   Lysine-specific histone demethylase 1
Schmidtea mediterranea mk4.004117.00   Lysine-specific histone demethylase 1A
Schmidtea mediterranea mk4.004117.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens lysine (K)-specific demethylase 1A Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0451 0.4504 0.4496
0.0563 0.5942 0.5942
0.0453 0.3521 0.3517
0.0083 0.9093 1
0.1263 0.7922 1
0.0083 0.8938 1
0.0136 0.416 0.5292
0.1126 0.9243 1
0.0137 0.8938 0.5
0.0137 0.7284 1
0.0453 0.3521 0.3517
0.018 0.2673 0.2753
0.1227 0.4266 1
0.0443 0.8934 1
0.0241 0.3136 0.3071
0.0918 0.2639 1
0.0065 1 1
0.0087 0.3247 0.3247
0.0362 0.4157 0.4125
0.0079 0.3809 1
0.0151 0.3793 0.3793
0.0133 0.4884 0.6794
0.1177 0.9208 1
0.0561 0.9154 1
0.0625 0.3644 0.3644
0.0083 0.3563 1
0.0135 0.4325 0.4325
0.0548 0.2713 0.2709
0.0417 0.2783 0.2783
0.0637 0.472 1
0.0083 0.904 1
0.1121 0.9238 1
0.0243 0.3692 1
0.0745 0.9254 1
0.028 0.92 1
0.0255 0.6236 1
0.0089 0.2534 0.8541
0.0185 0.4197 0.6345
0.045 0.9148 1
0.128 0.7349 1
0.0528 0.9154 1
0.0125 0.3061 1
0.1123 0.2725 1
0.0069 0.3488 1
0.0323 0.2932 0.2721
0.0169 0.3722 0.2424
0.0991 0.6849 0.6849
0.0568 0.3605 0.3604
0.0534 0.9138 1
0.0581 0.9209 1
0.0184 0.4506 0.6849
0.0472 0.3344 0.3343
0.0069 0.3088 0.8652
0.0111 0.3061 1
0.0247 0.2793 0.5
0.1049 0.6316 1
0.1593 0.6048 1
0.03 0.3174 0.3141
0.0224 0.4042 0.5585
0.1158 0.3513 0.7224
0.02 0.2835 1
0.0231 0.2622 0.2622
0.0358 0.9172 1
0.0605 0.904 1
0.1177 0.9208 1
0.1419 0.2598 1
0.0271 0.3666 1
0.0139 0.4381 0.4381
0.0433 0.2656 0.2656
0.0719 0.9207 1
0.0083 0.7219 0.7219
0.0251 0.3294 0.4032
0.0233 0.3336 0.333
0.041 0.9197 1
0.0607 0.9199 1
0.0258 0.358 0.6285
0.0548 0.904 1
0.022 0.7154 1
0.0403 0.4554 0.5
0.0083 0.5146 1
0.1124 0.922 1
0.0083 0.8938 0.5
0.1423 0.4398 1
0.0068 0.904 1
0.0385 0.254 0.252
0.0533 0.2714 1
0.1292 0.8111 1
0.0454 0.9154 1
0.014 0.7783 0.8313
0.0063 1 1
0.0991 0.6849 0.6849
0.0314 0.9179 1
0.1232 0.9238 1
0.073 0.275 1
0.0137 0.4491 0.7752
0.0137 0.8938 0.5
0.0311 0.349 0.349
0.1095 0.7302 1
0.0178 0.3747 0.3747
0.0513 0.5229 0.5864
0.0207 0.2804 1
0.0122 0.3357 0.3357
0.0173 0.3998 0.5899
0.0134 0.9154 1
0.0181 0.3696 0.5
0.0142 0.7364 1
0.0068 0.9006 1
0.0774 0.9214 1
0.0873 0.4102 1
0.0486 0.2692 1
0.0297 0.3042 0.3042
0.021 0.2643 0.3837
0.0102 0.3765 0.3765
0.0439 0.3516 1
0.0402 0.3279 0.3498
0.0289 0.9201 1
0.1062 0.9243 1
0.0991 0.6849 0.6849
0.1466 0.5966 1
0.0453 0.3521 0.3517
0.0347 0.5697 0.5697
0.0042 0.2805 0.6461
0.021 0.9154 1
0.025 0.3685 1
0.044 0.919 1
0.0314 0.9179 1
0.0489 0.5164 1
0.018 0.2673 0.2753
0.0067 0.3475 0.4533
0.0344 0.914 1
0.0064 1 1
0.0083 0.3212 0.3234
0.0068 0.8938 1
0.0069 0.3488 1
0.0201 0.3056 0.8319
0.0204 0.315 0.3933
0.0083 0.7051 0
0.021 0.8196 1
0.0546 0.2917 0.2917
0.0262 1 1
0.0262 1 1
0.0268 0.904 1
0.0408 0.9128 1
0.0171 0.3722 0.3879
0.1109 0.9254 1
0.0083 0.9073 1
0.0158 0.372 0.3952
0.1275 0.3277 0.3321
0.0246 0.3057 0.2875
0.0139 0.3599 1
0.0083 0.5146 1
0.0076 0.911 1
0.0472 0.3344 0.3343
0.0831 0.4971 0.4968
0.1161 0.9237 1
0.0177 0.2563 0.9476
0.0434 0.9111 1
0.1275 0.3277 0.3321
0.021 0.2744 1
0.0204 0.8754 0.8754
0.0227 0.9146 1
0.0221 0.9144 1
0.0083 0.904 1
0.1693 0.7663 1
0.0895 0.9249 1
0.0717 0.2635 1
0.0716 0.904 1
0.0299 0.7507 0.5
0.0083 0.9045 1
0.017 0.3396 0.5
0.0083 0.8938 0.5
0.0078 0.3809 0.7222
0.0159 0.3701 0.3692
0.0083 0.8938 0.5
0.0155 0.3494 0.3725
0.0083 0.8489 1
0.0048 0.6551 0.6178
0.7447 0.3029 1
0.0546 0.2917 0.2917
0.0083 0.904 1
0.1185 0.4346 1
0.0279 0.904 1
0.0155 0.3696 0.3667
0.0083 0.8938 0.5
0.0851 0.9215 1
0.024 0.3288 0.3288
0.0314 0.9179 1
0.0083 0.8938 0.5
0.0472 0.3344 0.3343
0.1 0.2641 0.8023
0.0083 0.8938 0.5
0.0108 0.2744 1
0.1651 0.2549 0.4875
0.1124 0.922 1
0.0621 0.904 1
0.0077 0.2722 0.2465
0.0208 0.3809 1
0.0067 0.3626 1
0.0481 0.92 1
0.2654 0.3671 1
0.0857 0.7805 1
0.0177 0.4028 0.4005
0.043 0.33 0.5229
0.0125 0.3061 1
0.0282 0.5 0.5
0.0478 0.2943 0.399
0.0563 0.5942 0.5942
0.0225 0.6121 0.6894
0.0062 1 1
0.00904827 0.89855 1
0.0349 0.4564 0.4525
0.0146 0.8808 0.8808
0.0661 0.389 0.7294
0.0083 0.904 1
0.0546496 0.399452 0.733743
0.0561 0.3465 0.3464
0.1065 0.9244 1
0.0873 0.4102 1
0.0071 0.7574 0.7445
0.0094 0.2651 0.4226
0.0169 0.2594 1
0.0992 0.6316 0.5
0.0501 0.4548 0.4548
0.0217 0.903 1
0.013 1 1
0.00877338 0.901345 1
0.041 0.9078 1
0.0959 0.9247 1
0.0481 0.92 1
0.2793 0.3861 1
0.052 0.5096 0.5096
0.1068 0.9243 1
0.1465 0.2772 1
0.0327 0.3138 0.4499
0.0231 0.2663 0.2663
0.0905 0.3676 0.7467
0.0384 0.5618 1
0.0216 0.4447 0
0.0379 0.5026 0.5007
0.0079 0.3809 1
0.0051 1 1
0.0227 0.3845 1
0.0225 0.6121 0.6894
0.0281 0.3312 0.3312
0.1006 0.2969 1
0.0241 0.3454 0.3274
0.116 0.7452 1
0.0063 1 1
0.0702 0.9154 1
0.0375 0.2803 0.2803
0.02 0.2805 0.2805
0.0524 0.2993 0.35
0.0139 0.9155 1
0.0071 0.3809 1
0.0142 0.7364 1
0.0213 0.2882 0.2882
0.0643 0.9209 1
0.0366 0.2606 1
0.0272 0.3442 0.4315
0.0553 0.9154 1
0.0576 0.2868 0.2868
0.0489 0.5164 1
0.0239 0.3073 0.3072
0.0419 1 1
0.0744 0.9257 1
0.0067 0.3626 1
0.0142 0.2825 0.356
0.0067 0.8997 1
0.1296 0.7069 1
0.0869 0.3981 0.7197
0.1074 0.7385 1
0.0432 0.3002 0.2991
0.1324 0.7881 0.5
0.1448 0.2966 1
0.0131 0.5 0.5
0.1292 0.904 1
0.0717 0.2635 1
0.0074 0.9082 1
0.025 0.3685 1
0.0711 0.9154 1
0.0064 1 1
0.0408 0.3061 1
0.0075 0.3809 1
0.0283 0.2896 0.7904
0.0083 0.3809 1
0.0717 0.2635 1
0.023 0.256 0.256
0.0073 0.5694 0.5694
0.1245 0.7735 1
0.1263 0.7922 1
0.0625 0.3644 0.3644
0.0086 0.5 0.5
0.0862 0.9226 1
0.0135 0.6054 0.6054
0.0356338 0.442179 0.341087
0.1373 0.9235 1
0.1275 0.3277 0.3321
0.0283 0.9134 1
0.0509 0.3154 0.697
0.0085 1 1
0.0653 0.2575 1
0.0104 0.2744 1
0.0271 0.2688 0.2687
0.0135 0.4782 0.5
0.0204 0.4127 0.5249
0.0487 0.4286 0.4286
0.0839 0.2639 1
0.052 0.5096 0.5096
0.0099 0.2744 1
0.7447 0.3029 1
0.0305 0.3272 0.3272
0.0903 0.3099 0.5848
0.0073 0.9002 1
0.1095 0.7302 1
0.0761 0.9242 1
0.0147 0.3861 1
0.0422 0.9154 1
0.0225 0.6121 0.6894
0.0108 1 1
0.043 0.33 0.5229
0.041 0.9197 1
0.0125 0.3061 1
0.0202 0.3263 0.2902
0.0449 0.6539 0.6416
0.021 0.8196 1
0.1185 0.4346 1
0.0299 0.7507 0.5
0.0483 0.4778 0.6054
0.0305 0.3272 0.3272
0.0075 0.2911 1
0.0289 0.8955 1
0.0908 0.3711 0.925
0.0103 0.2586 1
0.0399 0.6831 1
0.0581 0.3365 0.3365
0.0272 1 1
0.0989 0.924 1
0.0348 0.9138 1
0.0083 0.4451 0.4451
0.0495 0.2773 0.2772
0.0851 0.9215 1
0.0411 0.4762 1
0.0072 0.2909 1
0.1245 0.9202 1
0.1264 0.2734 1
0.0235 0.3809 1
0.0488 0.9201 1
0.0668 0.3694 1
0.1745 0.2507 1
0.0436 0.9166 1
0.0083 0.9045 1
0.0717 0.2635 1
0.1112 0.5655 1
0.0563 0.5942 0.5942
0.101 0.9256 1
0.0227 0.3845 1
0.0434 0.9111 1
0.1074 0.7385 1
0.0605 0.904 1
0.0176 0.3619 0.5
0.0308 0.8467 0.8467
0.0083 0.8938 0.5
0.0083 0.8938 1
0.0652 0.9235 1
0.0083 0.8938 0.5
0.0403 0.308 0.5
0.0487 0.4286 0.4286
0.0153 1 1
0.127 0.7462 0.5
0.0165 0.2689 0.2689
0.1283 0.8167 1
0.0717 0.2635 1
0.0417 0.2783 0.2783
0.1074 0.7385 1
0.0023 0.5 0.5
0.0717 0.2635 1
0.0042 0.5 0.5
0.0142 0.2825 0.356
0.0083 0.8938 0.5
0.0083 0.4163 0
0.0751 0.3764 0.376
0.1075 0.3084 1
0.0652 0.9235 1
0.014 0.9532 1
0.0141 0.6804 0.6779
0.0139 0.8938 1
0.0224 0.5817 0.5817
0.0225 0.6121 0.6894
0.0235 0.2801 0.2801
0.023 0.3809 1
0.0203 0.2739 0.2739
0.007 0.9131 1
0.1245 0.7735 1
0.1293 0.8938 0.5
0.0135 0.4782 0.5
0.0717 0.2635 1
0.0079 0.3809 1
0.008 0.3146 0
0.0083 0.3572 0.2784
0.0384 0.5846 0.9686
0.0462 0.285 0.2842
0.1167 0.7448 1
0.0074 0.3587 1
0.1074 0.7385 1
0.0083 0.5146 1
0.7631 0.293 1
0.0299 0.7507 0.5
0.0083 0.8938 0.5
0.6336 0.2977 0.8414
0.0229 0.3809 1
0.0429 0.9182 1
0.0083 0.8938 0.5
0.0281 0.3312 0.3312
0.1289 0.7233 0.5
0.0982 0.9245 1
0.0125 0.3061 1
0.011 0.3084 0.4891
0.1254 0.7435 0.5
0.0025 0.4128 0.4601
0.0173 0.3583 1
0.0235 0.574 0.5
0.0073 0.5694 0.5694
0.0203 0.2739 0.2739
0.0156 0.6931 0
0.0561 0.3465 0.3464
0.0393 0.3367 0.3352
0.0284 0.9137 1
0.0155 0.3809 1
0.0168 0.4236 1
0.1149 0.9242 1
0.0594 0.8129 1
0.0467 0.2675 1
0.0138 0.7471 1
0.0108 0.2744 1
0.0786 0.7684 0.7684
0.0152 0.3809 1
0.0174 0.2545 1
0.00978849 0.89855 1
0.0133 0.4884 0.6794
0.0168 0.4236 1
0.0717 0.2635 1
0.0069 0.3809 1
0.022 0.7154 1
0.0912 0.6677 1
0.0219 0.5915 1
0.0071 0.3809 1
0.1651 0.2549 0.4875
0.1275 0.3277 0.3321
0.0726 0.6663 1
0.0991 0.6849 0.6849
0.0083 0.3876 0.3876
0.0298 0.3739 0.3739
0.0326 0.3061 1
0.0139 0.9104 1
0.0187 0.2838 1
0.2693 0.464 1
0.0447 0.2863 0.6341
0.02 0.4919 0.4919
0.0083 0.4067 0.4067
0.043 0.6228 0.6228
0.0394 0.4491 0.5
0.0125 0.3061 1
0.0273 0.3606 0.9812
0.0206 0.3963 0.4188
0.0646 0.9154 1
0.0209 0.3415 0.3415
0.031 0.4039 0.4039
0.0076 0.3809 1
0.0109 1 1
0.0917 0.5443 1
0.0548 0.5315 0.6478
0.0041 1 1
0.0417 0.2783 0.2783
0.0282 0.904 1
0.0553 0.904 1
0.0391 0.4404 0.4404
0.1169 0.9254 1
0.0717 0.2635 1
0.1257 0.7464 0.5
0.0069 0.3088 0.8652
0.7883 0.2661 1
0.0135 0.4164 0.4087
0.0173 0.3998 0.5899
0.0213 0.2729 0.5928
0.036 0.2888 0.5124
0.042 0.3257 1
0.043 0.33 0.5229
0.0717 0.2635 1
0.0233 0.3809 1
0.0217 0.5666 0.5666
0.1155 0.7753 1
0.0371 0.3831 0.3831
0.0242 0.3085 0.3085
0.0083 0.9007 1
0.0138 0.8934 0.6636
0.0083 0.3365 0
0.0605 0.904 1
0.0375 0.4096 0.4096
0.0282 0.3765 0.3714
0.0078 0.3809 1
0.0469 0.2641 0.5335
0.115 0.9241 1
0.0207 0.9032 1
0.8337 0.2786 1
0.0348 0.9202 0.962
0.0176 0.3619 0.5
0.0205 0.6422 0.8346
0.0289 0.8955 1
0.0424 0.3226 1
0.0083 0.8938 1
0.0796 0.9212 1
0.073 0.275 1
0.0524 0.2993 0.35
0.0083 0.8724 1
0.0522 0.4768 0.4768
0.0322 0.4588 1
0.0083 0.3809 1
0.0108 0.2744 1
0.0546 0.6963 0.6963
0.0217 1 1
0.0307 0.3633 0.3633
0.1117 0.7026 0.5
0.0311 0.349 0.349
0.0311 0.349 0.349
0.0453 0.3521 0.3517
0.0144 0.3535 0.3535
0.022 0.534 0.5272
0.0068 0.8938 1
0.1158 0.3513 0.7224
0.0385 0.254 0.252
0.2654 0.3671 1
0.0242 0.3841 0.42
0.0944 0.9202 1
0.0308 0.8467 0.8467
0.0354 0.9176 0.9468
0.0599 0.9167 1
0.021 0.2744 1
0.0072 0.2909 1
0.0083 0.8938 0.5
0.044 0.4275 0.4275
0.0083 0.398 1
0.0281 0.3312 0.3312
0.0067 0.904 1
0.8471 0.2567 1
0.0432 0.9154 1
0.0134 0.9103 1
0.059 0.8548 1
0.0417 0.4007 1
0.0796 0.3062 0.4928
0.0083 0.8938 0.5
0.0209 0.5455 0.5406
0.0104 0.2744 0.7967
0.0456 0.4429 0.4429
0.0067 0.3295 0.391
0.0592 0.7835 0.5
0.1219 0.7458 0.5
0.0446 0.2583 1
0.0218 0.8975 1
0.0284 0.9196 1
0.0239 0.2732 1
0.0094 0.2651 0.4226
0.1171 0.6904 0.5
0.0292 0.9154 1
0.0213 0.2882 0.2882
0.1795 0.2511 1
0.0169 0.3068 0.547
0.0256 0.3668 1
0.0242 0.3085 0.3085
0.1218 0.2681 1
0.0072 0.2909 1
0.0023 0.5 0.5
0.0429 0.9179 0.9487
0.0484 0.5591 0.5591
0.035 0.3764 0.3659
0.0604 0.3192 0.3635
0.008 0.904 1
0.0207 0.256 0.2555
0.017 0.4051 1
0.0079 0.3809 1
0.0083 0.5342 0
0.0492 0.5653 0.5653
0.0147 0.9159 1
0.0853 0.8187 1
0.0202 0.2902 0.2291
0.0142 0.3381 0.4229
0.0083 0.9056 1
0.0563 0.5942 0.5942
0.0079 0.3809 1

Assayability

Assay information

No assay information for this target.

Reagent availability

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Gene identifier EmuJ_000095900 (Echinococcus multilocularis), lysine specific histone demethylase 1A
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