Detailed information for compound 323759

Basic information

Technical information
  • TDR Targets ID: 323759
  • Name: 4-(5-chloro-2-hydroxyphenyl)-3-[2-(4-methylpi perazin-1-yl)-2-oxoethyl]sulfanyl-6-(trifluor omethyl)-1H-quinolin-2-one
  • MW: 511.944 | Formula: C23H21ClF3N3O3S
  • H donors: 2 H acceptors: 4 LogP: 4.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN1CCN(CC1)C(=O)CSc1c(O)nc2c(c1c1cc(Cl)ccc1O)cc(cc2)C(F)(F)F
  • InChi: 1S/C23H21ClF3N3O3S/c1-29-6-8-30(9-7-29)19(32)12-34-21-20(16-11-14(24)3-5-18(16)31)15-10-13(23(25,26)27)2-4-17(15)28-22(21)33/h2-5,10-11,31H,6-9,12H2,1H3,(H,28,33)
  • InChiKey: DROAXDKMEJHTFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(5-chloro-2-hydroxy-phenyl)-3-[2-(4-methylpiperazin-1-yl)-2-oxo-ethyl]sulfanyl-6-(trifluoromethyl)-1H-quinolin-2-one
  • 4-(5-chloro-2-hydroxyphenyl)-3-[[2-(4-methyl-1-piperazinyl)-2-oxoethyl]thio]-6-(trifluoromethyl)-1H-quinolin-2-one
  • 4-(5-chloro-2-hydroxy-phenyl)-3-[[2-keto-2-(4-methylpiperazino)ethyl]thio]-6-(trifluoromethyl)carbostyril
  • 4-(5-chloro-2-hydroxy-phenyl)-3-[[2-keto-2-(4-methylpiperazin-1-yl)ethyl]thio]-6-(trifluoromethyl)carbostyril

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0028 0.0071
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.004 0.0101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0152 0.015
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0052 0.009 0.0225
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0052 0.009 0.0225
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0009 0.0021
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0428 0.1102 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0066 0.0166
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0044 0.011
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0428 0.1102 1
Leishmania major quinonoid dihydropteridine reductase 0.0052 0.009 0.0225
Mycobacterium tuberculosis Probable reductase 0.0118 0.0267 0.0266
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0052 0.009 0.0225
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0052 0.009 0.0225
Brugia malayi intermediate filament protein 0.0057 0.0104 0.0261
Leishmania major hypothetical protein, conserved 0.0052 0.009 0.0225
Leishmania major hypothetical protein, conserved 0.0075 0.0152 0.0381
Brugia malayi nuclear receptor NHR-88 0.0021 0.0009 0.0021
Schistosoma mansoni glutathione synthetase 0.0428 0.1102 0.2762
Schistosoma mansoni Smad4 0.0035 0.0044 0.011
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Giardia lamblia Farnesyl diphosphate synthase 0.1502 0.3989 1
Brugia malayi jmjC domain containing protein 0.0025 0.0018 0.0046
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0025 0.0055
Plasmodium vivax importin-beta 2, putative 0.0028 0.0027 0.005
Onchocerca volvulus Hexokinase homolog 0.0039 0.0057 0.0378
Brugia malayi Bromodomain containing protein 0.0148 0.0348 0.0873
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0073 0.0184
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0072 0.0144 0.1307
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0084 0.0211
Brugia malayi Fli-1 protein 0.0219 0.0539 0.1351
Trypanosoma brucei short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Onchocerca volvulus 0.0075 0.0152 0.1122
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0021
Loa Loa (eye worm) oxidoreductase 0.0052 0.009 0.0225
Trypanosoma cruzi short chain dehydrogenase, putative 0.0052 0.009 0.0225
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0009 0.0021
Schistosoma mansoni inositol monophosphatase 0.0072 0.0144 0.0361
Brugia malayi Probable ClpP-like protease 0.0088 0.0187 0.0468
Brugia malayi Pre-SET motif family protein 0.0437 0.1126 0.2822
Schistosoma mansoni carbonyl reductase 0.0052 0.009 0.0225
Schistosoma mansoni hypothetical protein 0.003 0.0031 0.0078
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.009 0.0225
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Echinococcus granulosus WW domain containing oxidoreductase 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0077 0.0158 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0009 0.0021
Brugia malayi Protein cec-1. 0.0022 0.0011 0.0029
Brugia malayi hexokinase type II 0.002 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0029
Leishmania major 3-keto-dihydrosphingosine reductase 0.0052 0.009 0.0225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.021 0.0527
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0029
Leishmania major quinonoid dihydropteridine reductase 0.0052 0.009 0.0225
Brugia malayi jmjC domain containing protein 0.0025 0.0018 0.0046
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.006 0.0149
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0104 0.0261
Brugia malayi MH2 domain containing protein 0.0035 0.0044 0.011
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0022 0.0011 0.0029
Leishmania major short chain dehydrogenase/reductase, putative 0.0052 0.009 0.0225
Echinococcus multilocularis steroid dehydrogenase 0.0052 0.009 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0097 0.0244
Brugia malayi Heterochromatin protein 1 0.0137 0.0319 0.08
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0018 0.0041
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0428 0.1102 0.11
Leishmania major hexokinase, putative 0.0063 0.012 0.03
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0052 0.009 0.0225
Brugia malayi Pre-SET motif family protein 0.0063 0.0121 0.0303
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Trichomonas vaginalis steroid dehydrogenase, putative 0.0052 0.009 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0018 0.0046
Toxoplasma gondii carbonyl reductase 1, putative 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0021
Trichomonas vaginalis chromobox protein, putative 0.0137 0.0319 0.08
Echinococcus multilocularis lysine specific demethylase 5A 0.0094 0.0203 0.0449
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0052 0.009 0.0209
Trypanosoma brucei protein kinase, putative 0.0049 0.0084 0.0211
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0189 0.0458 0.1148
Schistosoma mansoni inositol monophosphatase 0.0072 0.0144 0.0361
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0028 0.0071
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0029
Trichomonas vaginalis set domain proteins, putative 0.0497 0.1288 0.3228
Leishmania major trypanothione reductase 0.0052 0.009 0.0225
Brugia malayi MH2 domain containing protein 0.0035 0.0044 0.011
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0002 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Schistosoma mansoni hypothetical protein 0.0537 0.1395 0.3497
Toxoplasma gondii thioredoxin reductase 0.0052 0.009 0.0225
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1502 0.3989 1
Echinococcus multilocularis tar DNA binding protein 0.0257 0.0643 0.1422
Echinococcus granulosus retinol dehydrogenase 11 0.0052 0.009 0.0225
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0009 0.0021
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Mycobacterium ulcerans short-chain dehydrogenase 0.0052 0.009 0.0088
Onchocerca volvulus 0.0052 0.009 0.0636
Schistosoma mansoni lamin 0.0057 0.0104 0.0261
Onchocerca volvulus 0.0052 0.009 0.0636
Brugia malayi beta-lactamase family protein 0.0075 0.0152 0.0381
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.009 0.0209
Loa Loa (eye worm) RNA binding protein 0.0257 0.0643 0.1612
Schistosoma mansoni intermediate filament proteins 0.0057 0.0104 0.0261
Brugia malayi hypothetical protein 0.0052 0.009 0.0225
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.006 0.0133
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0032 0.0064
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Trypanosoma brucei short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.006 0.0132
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0052 0.009 0.0088
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0052 0.009 0.0225
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.0228 0.0503
Onchocerca volvulus 0.0052 0.009 0.0636
Leishmania major GTP-binding protein, putative 0.0021 0.0007 0.0017
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0052 0.009 0.0816
Brugia malayi Dehydrogenases, short chain protein 2 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0144 0.0361
Treponema pallidum hexokinase (hxk) 0.0063 0.012 0.0541
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Schistosoma mansoni steroid dehydrogenase 0.0052 0.009 0.0225
Brugia malayi CHD4 protein 0.0028 0.0026 0.0064
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0084 0.0211
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Entamoeba histolytica hypothetical protein 0.0189 0.0458 0.4158
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0152 0.0381
Echinococcus multilocularis smad 0.0035 0.0044 0.0097
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0052 0.009 0.0225
Entamoeba histolytica short chain dehydrogenase family protein 0.0052 0.009 0.0816
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0064 0.0124 0.0122
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0033 0.0083
Onchocerca volvulus 0.0028 0.0026 0.0135
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0187 0.0452
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.006 0.0149
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0173 0.0434
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0086 0.0181 0.0454
Brugia malayi M-phase phosphoprotein, mpp8 0.0022 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0075 0.0152 0.0381
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0428 0.1102 0.2762
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0019 0.0048
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0018 0.0046
Trypanosoma brucei short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Plasmodium falciparum importin beta, putative 0.0028 0.0027 0.005
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0052 0.009 0.0816
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0106 0.0265
Loa Loa (eye worm) hexokinase 0.0019 0.0003 0.0008
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0044 0.011
Loa Loa (eye worm) hypothetical protein 0.0088 0.0187 0.0468
Echinococcus granulosus phd:f box containing protein 0.0025 0.0018 0.0046
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0052 0.009 0.0199
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0018 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0029
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0477 0.1234 0.1233
Schistosoma mansoni carbonyl reductase 0.0052 0.009 0.0225
Mycobacterium ulcerans dehydrogenase/reductase 0.0052 0.009 0.0088
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0052 0.009 0.0816
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0428 0.1102 0.2435
Entamoeba histolytica hypothetical protein 0.0189 0.0458 0.4158
Loa Loa (eye worm) hypothetical protein 0.0065 0.0125 0.0313
Echinococcus multilocularis carbonyl reductase 1 0.0052 0.009 0.0199
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.0187 0.0468
Leishmania major short chain dehydrogenase/reductase, putative 0.0052 0.009 0.0225
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0052 0.009 0.0088
Loa Loa (eye worm) oxidoreductase 0.0052 0.009 0.0225
Echinococcus granulosus hexokinase 0.0063 0.012 0.03
Brugia malayi glutaminase DH11.1 0.0276 0.0692 0.1735
Leishmania major short chain dehydrogenase, putative 0.0052 0.009 0.0225
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0052 0.009 0.0225
Schistosoma mansoni jumonji domain containing protein 0.0133 0.031 0.0776
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0207 0.0519
Mycobacterium ulcerans short-chain dehydrogenase 0.0052 0.009 0.0088
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0009 0.0021
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0084 0.0211
Onchocerca volvulus 0.0063 0.012 0.0868
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0084 0.0211
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.0017
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0007 0.0015
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0135 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0333 0.0737
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0056
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0009 0.0021
Brugia malayi MH2 domain containing protein 0.0507 0.1313 0.3291
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0084 0.0211
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0052 0.009 0.0538
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0033 0.0083
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.1126 0.2822
Leishmania major importin beta-1 subunit, putative 0.0023 0.0012 0.0031
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0018 0.0046
Schistosoma mansoni smad1 5 8 and 0.0035 0.0044 0.011
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Loa Loa (eye worm) hypothetical protein 0.0079 0.0164 0.0412
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0018 0.0046
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0428 0.1102 0.11
Toxoplasma gondii oxidoreductase, putative 0.0052 0.009 0.0225
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0009 0.0021
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0084 0.0211
Mycobacterium tuberculosis Probable oxidoreductase 0.0052 0.009 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0018 0.0046
Echinococcus granulosus snurportin 1 0.0299 0.0756 0.1894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0333 0.0836
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0286 0.0717
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0018 0.0046
Schistosoma mansoni steroid dehydrogenase 0.0052 0.009 0.0225
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.009 0.0225
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0428 0.1102 0.275
Loa Loa (eye worm) oxidoreductase 0.0052 0.009 0.0225
Brugia malayi SET domain containing protein 0.0025 0.0019 0.0048
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0121 0.0268
Brugia malayi hypothetical protein 0.0189 0.0458 0.1148
Echinococcus multilocularis snurportin 1 0.0299 0.0756 0.167
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.0267 0.0266
Brugia malayi jmjC domain containing protein 0.0099 0.0217 0.0545
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0052 0.009 0.0225
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0002 0.0004
Brugia malayi Hexokinase family protein 0.0039 0.0057 0.0142
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0052 0.009 0.0225
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0009 0.0021
Brugia malayi Dehydrogenases, short chain protein 30 0.0052 0.009 0.0225
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Trypanosoma brucei unspecified product 0.0019 0.0002 0.0004
Giardia lamblia Reductase, putative 0.0052 0.009 0.0225
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Brugia malayi hypothetical protein 0.0022 0.0011 0.0029
Echinococcus multilocularis lamin 0.0057 0.0104 0.023
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0052 0.009 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0009 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0333 0.0836
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.009 0.0225
Echinococcus multilocularis inositol monophosphatase 1 0.0072 0.0144 0.0318
Brugia malayi steroid hormone receptor 0.0021 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0021
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0026 0.0065
Trichomonas vaginalis chromobox protein, putative 0.0022 0.0011 0.0029
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0228 0.057
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.0187 0.0452
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0004
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0052 0.009 0.0225
Leishmania major quinonoid dihydropteridine reductase 0.0052 0.009 0.0225
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0537 0.1395 0.3497
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0011 0.0104
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0018 0.0046
Loa Loa (eye worm) glutaminase 2 0.0276 0.0692 0.1735
Schistosoma mansoni importin beta-1 0.0028 0.0027 0.0067
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0104 0.0261
Leishmania major quinonoid dihydropteridine reductase 0.0052 0.009 0.0225
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0301 0.076 0.1904
Echinococcus granulosus tar DNA binding protein 0.0257 0.0643 0.1612
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Brugia malayi MAP kinase sur-1 0.0049 0.0084 0.0211
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.004 0.0101
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0027 0.0067
Loa Loa (eye worm) hypothetical protein 0.0075 0.0152 0.0381
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.0187 0.1443
Echinococcus granulosus retinol dehydrogenase 11 0.0052 0.009 0.0225
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0063
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.0228 0.057
Echinococcus multilocularis chromobox protein 1 0.0137 0.0319 0.0706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.021 0.0527
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0052 0.009 0.0225
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.063 0.1643 0.412
Leishmania major DNA polymerase eta, putative 0.0019 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0119 0.0271 0.0679
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0228 0.057
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0009 0.0019
Trichomonas vaginalis esterase, putative 0.0075 0.0152 0.0381
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0009 0.0021
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0084 0.0186
Leishmania major quinonoid dihydropteridine reductase 0.0052 0.009 0.0225
Schistosoma mansoni hypothetical protein 0.0395 0.1013 0.254
Schistosoma mansoni smad 0.0035 0.0044 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0009 0.0021
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Mycobacterium ulcerans ketoacyl reductase 0.0052 0.009 0.0088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.006 0.0149
Brugia malayi TAR-binding protein 0.0257 0.0643 0.1612
Mycobacterium tuberculosis Conserved protein 0.0075 0.0152 0.015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0011 0.0029
Brugia malayi beta-lactamase 0.0075 0.0152 0.0381
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.0267 0.0266
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.0187 0.0413
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0052 0.009 0.0088
Leishmania major oxidoreductase-like protein 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Onchocerca volvulus 0.0052 0.009 0.0636
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0002 0.0004
Mycobacterium ulcerans dehydrogenase 0.0052 0.009 0.0088
Schistosoma mansoni trans-prenyltransferase 0.0428 0.1102 0.2762
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0152 0.0381
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0207 0.0519
Loa Loa (eye worm) hypothetical protein 0.0096 0.021 0.0527
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0052 0.009 0.0199
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0022 0.0011 0.0012
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0428 0.1102 0.2762
Echinococcus granulosus GPCR family 2 0.0095 0.0207 0.0519
Brugia malayi dehydrogenases, short chain protein 2 0.0052 0.009 0.0225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0028 0.0071
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Echinococcus granulosus dna polymerase eta 0.0019 0.0002 0.0004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.006 0.0149
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1502 0.3989 1
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0011 0.0012
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0217 0.0545
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0018 0.0046
Brugia malayi glutathione reductase 0.0052 0.009 0.0225
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0152 0.0381
Echinococcus granulosus biogenic amine 5HT receptor 0.0375 0.096 0.2407
Onchocerca volvulus 0.006 0.0113 0.0816
Echinococcus multilocularis carbonyl reductase 1 0.0052 0.009 0.0199
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0052 0.009 0.0225
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.009 0.0225
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0002 0.0004
Mycobacterium ulcerans short-chain type oxidoreductase 0.0052 0.009 0.0088
Echinococcus granulosus cpg binding protein 0.0033 0.004 0.01
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0011 0.0104
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0017
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.0343 0.0759
Entamoeba histolytica hypothetical protein 0.0023 0.0012 0.0112
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Schistosoma mansoni microtubule-associated protein tau 0.1367 0.3624 0.9086
Schistosoma mansoni hypothetical protein 0.004 0.0059 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0028 0.0053
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0187 0.0468
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.006 0.0149
Loa Loa (eye worm) hypothetical protein 0.0301 0.076 0.1904
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Loa Loa (eye worm) helicase 0.0022 0.0011 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0009 0.0019
Echinococcus granulosus carbonyl reductase 1 0.0052 0.009 0.0225
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0428 0.1102 0.2762
Brugia malayi Hexokinase family protein 0.0019 0.0003 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0152 0.015
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0002 0.0004
Plasmodium falciparum hexokinase 0.0063 0.012 0.0283
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0333 0.0836
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0052 0.009 0.0225
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Schistosoma mansoni gabp alpha 0.0072 0.0145 0.0363
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.021 0.0527
Entamoeba histolytica hypothetical protein 0.0022 0.0011 0.0104
Brugia malayi Melibiase family protein 0.0069 0.0135 0.034
Entamoeba histolytica hexokinase 2 0.0063 0.012 0.1085
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0084 0.0211
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0145 0.032
Trichomonas vaginalis hypothetical protein 0.0022 0.0011 0.0029
Leishmania major hexokinase, putative 0.0063 0.012 0.03
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0009 0.0021
Schistosoma mansoni mucolipin 0.0072 0.0145 0.0362
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1502 0.3989 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0144 0.0361
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0018 0.0046
Schistosoma mansoni zinc finger protein 0.003 0.0031 0.0078
Echinococcus granulosus tumor protein p63 0.0669 0.175 0.4386
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0012 0.0031
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0052 0.009 0.0225
Plasmodium vivax heterochromatin protein 1, putative 0.0022 0.0011 0.0012
Mycobacterium ulcerans short-chain dehydrogenase 0.0052 0.009 0.0088
Brugia malayi Calcitonin receptor-like protein seb-1 0.0301 0.076 0.1904
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0152 0.0336
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0052 0.009 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0152 0.0381
Loa Loa (eye worm) glutathione reductase 0.0052 0.009 0.0225
Echinococcus multilocularis hexokinase 0.0063 0.012 0.0264
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0017
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0029
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0207 0.0519
Brugia malayi MH1 domain containing protein 0.0035 0.0044 0.011
Schistosoma mansoni hypothetical protein 0.0125 0.0286 0.0717
Echinococcus granulosus hexokinase 0.0063 0.012 0.03
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0069
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0018 0.0046
Echinococcus multilocularis Chromo domain 0.0022 0.0011 0.0025
Loa Loa (eye worm) hexokinase type II 0.0063 0.012 0.03
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0257 0.0643 0.1612
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.009 0.0225
Brugia malayi PHD-finger family protein 0.0028 0.0028 0.0069
Toxoplasma gondii ABC1 family protein 0.0075 0.0152 0.0381
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0052 0.009 0.0225
Mycobacterium ulcerans lipase LipD 0.0075 0.0152 0.015
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0018 0.0046
Echinococcus multilocularis hexokinase 0.0063 0.012 0.0264
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Mycobacterium tuberculosis Conserved protein 0.0075 0.0152 0.015
Echinococcus granulosus importin subunit beta 1 0.0028 0.0027 0.0067
Leishmania major quinonoid dihydropteridine reductase 0.0052 0.009 0.0225
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Toxoplasma gondii oxidoreductase, putative 0.0052 0.009 0.0225
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0333 0.0836
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0052 0.009 0.0636
Mycobacterium ulcerans oxidoreductase 0.0052 0.009 0.0088
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.009 0.0225
Mycobacterium tuberculosis Possible oxidoreductase 0.0052 0.009 0.0088
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0052 0.009 0.0816
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0011 0.0012
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1502 0.3989 1
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0097 0.0244
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0015 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0021
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.0228 0.0503
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.009 0.0088
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0152 0.0381
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Loa Loa (eye worm) polyprenyl synthetase 0.1502 0.3989 1
Schistosoma mansoni ap endonuclease 0.004 0.006 0.0149
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.0187 0.0468
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0121 0.0303
Loa Loa (eye worm) dehydrogenase 0.0052 0.009 0.0225
Schistosoma mansoni ets-related 0.0219 0.0539 0.1351
Onchocerca volvulus 0.0022 0.0011 0.0023
Mycobacterium tuberculosis Possible oxidoreductase 0.0052 0.009 0.0088
Trichomonas vaginalis inositol monophosphatase, putative 0.0072 0.0144 0.0361
Brugia malayi Polyprenyl synthetase family protein 0.0428 0.1102 0.2762
Schistosoma mansoni hypothetical protein 0.0299 0.0756 0.1894
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0158 0.0395
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0018 0.0046
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.1013 0.224
Loa Loa (eye worm) mucolipin 1 0.0072 0.0145 0.0362
Brugia malayi Associated with TFs and helicases family protein 0.0022 0.0011 0.0029
Brugia malayi hypothetical protein 0.0052 0.009 0.0225
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0028 0.0069
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0106 0.0233
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0145 0.0363
Plasmodium falciparum glutathione reductase 0.0052 0.009 0.0209
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0106 0.0104
Loa Loa (eye worm) glutaminase 0.0276 0.0692 0.1735
Mycobacterium leprae Probable lipase LipE 0.0075 0.0152 0.112
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0022 0.0011 0.0029
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0022 0.0011 0.0029
Entamoeba histolytica hypothetical protein 0.0189 0.0458 0.4158
Loa Loa (eye worm) transcription factor SMAD2 0.0507 0.1313 0.3291
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0428 0.1102 0.11
Entamoeba histolytica hypothetical protein 0.0025 0.0018 0.0165
Brugia malayi MH1 domain containing protein 0.0019 0.0003 0.0006
Onchocerca volvulus 0.0052 0.009 0.0636
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0018 0.004
Echinococcus multilocularis chromobox protein 1 0.0137 0.0319 0.0706
Schistosoma mansoni tar DNA-binding protein 0.0257 0.0643 0.1612
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Leishmania major short chain dehydrogenase, putative 0.0052 0.009 0.0225
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0052 0.009 0.0225
Onchocerca volvulus Huntingtin homolog 0.0119 0.0271 0.2052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0333 0.0836
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.009 0.0225
Echinococcus granulosus mucolipin 3 0.0072 0.0145 0.0362
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0428 0.1102 0.11
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.004 0.0101
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0153 0.0361 0.0905
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0052 0.009 0.0225
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0052 0.009 0.0088
Leishmania major solanesyl-diphosphate synthase, putative 0.0428 0.1102 0.2762
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Entamoeba histolytica hypothetical protein 0.0022 0.0011 0.0104
Brugia malayi Bromodomain containing protein 0.0075 0.0152 0.038
Schistosoma mansoni steroid dehydrogenase 0.0052 0.009 0.0225
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0002 0.0004
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0058 0.0127
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0002 0.0004
Trypanosoma brucei ISWI complex protein 0.003 0.0031 0.0078
Echinococcus multilocularis zinc finger protein 0.004 0.0058 0.0128
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Onchocerca volvulus 0.0052 0.009 0.0636
Loa Loa (eye worm) bromodomain containing protein 0.0034 0.0044 0.011
Trypanosoma brucei trypanothione reductase 0.0052 0.009 0.0225
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0021
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0052 0.009 0.0225
Echinococcus granulosus steroid dehydrogenase 0.0052 0.009 0.0225
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0428 0.1102 1
Trichomonas vaginalis glutaminase, putative 0.0276 0.0692 0.1735
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0044 0.0097
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0052 0.009 0.0225
Echinococcus multilocularis chromobox protein 2 0.0022 0.0011 0.0025
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0009 0.0021
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0152 0.0381
Brugia malayi MH1 domain containing protein 0.0035 0.0044 0.011
Loa Loa (eye worm) nuclear factor I 0.0019 0.0003 0.0006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0009 0.0019
Trypanosoma cruzi polyprenyl synthase, putative 0.063 0.1643 0.412
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.009 0.0225
Echinococcus multilocularis mucolipin 3 0.0072 0.0145 0.032
Mycobacterium tuberculosis Probable oxidoreductase 0.0052 0.009 0.0088
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0052 0.009 0.0636
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0009 0.0021
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0022 0.0011 0.0029
Schistosoma mansoni steroid dehydrogenase 0.0052 0.009 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0257 0.0643 0.1612
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0009 0.0019
Echinococcus granulosus hypothetical protein 0.0052 0.009 0.0225
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Echinococcus multilocularis hexokinase type 2 0.0063 0.012 0.0264
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0009 0.0021
Onchocerca volvulus 0.0052 0.009 0.0636
Brugia malayi hypothetical protein 0.0119 0.0271 0.0679
Mycobacterium ulcerans carveol-like dehydrogenase 0.0052 0.009 0.0088
Echinococcus multilocularis lamin dm0 0.0057 0.0104 0.023
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0069 0.0135 0.034
Echinococcus granulosus chromobox protein 1 0.0137 0.0319 0.08
Mycobacterium ulcerans hypothetical protein 0.0075 0.0152 0.015
Trypanosoma brucei hexokinase, putative 0.0063 0.012 0.03
Mycobacterium tuberculosis Probable oxidoreductase 0.0052 0.009 0.0088
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0009 0.0021
Echinococcus granulosus carbonyl reductase 1 0.0052 0.009 0.0225
Mycobacterium ulcerans oxidoreductase 0.0052 0.009 0.0088
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0052 0.009 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0333 0.0836
Echinococcus multilocularis carbonyl reductase 1 0.0052 0.009 0.0199
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0029
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0018 0.0046
Brugia malayi Importin beta-1 subunit 0.0028 0.0027 0.0067
Echinococcus granulosus zinc finger protein 0.004 0.0058 0.0145
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.009 0.0225
Schistosoma mansoni steroid dehydrogenase 0.0052 0.009 0.0225
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0052 0.009 0.0538
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Echinococcus granulosus dna polymerase kappa 0.0019 0.0002 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0009 0.0021
Trypanosoma brucei short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0009 0.0021
Schistosoma mansoni smad1 5 8 and 0.0035 0.0044 0.011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0104 0.0261
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0056
Leishmania major quinonoid dihydropteridine reductase 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0029
Entamoeba histolytica hypothetical protein 0.0052 0.009 0.0816
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0302 0.0301
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.0504 0.1263
Brugia malayi Thioredoxin reductase 0.0052 0.009 0.0225
Entamoeba histolytica hypothetical protein 0.0189 0.0458 0.4158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0009 0.0021
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0011 0.0029
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.021 0.0465
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0152 0.0381
Toxoplasma gondii hexokinase 0.0063 0.012 0.03
Plasmodium falciparum heterochromatin protein 1 0.0022 0.0011 0.0012
Onchocerca volvulus 0.0075 0.0152 0.1122
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0028 0.0069
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0187 0.0185
Echinococcus multilocularis conserved hypothetical protein 0.0052 0.009 0.0199
Loa Loa (eye worm) hypothetical protein 0.0056 0.0101 0.0254
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.0756 0.1894
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0052 0.009 0.0088
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0073 0.0162
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0028 0.0069
Trypanosoma cruzi ISWI complex protein 0.003 0.0031 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0009 0.0021
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.0267 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Leishmania major short chain dehydrogenase-like protein 0.0052 0.009 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0029
Loa Loa (eye worm) hexokinase 0.0063 0.012 0.03
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Echinococcus multilocularis peregrin 0.0033 0.004 0.0089
Brugia malayi ecdysteroid receptor 0.0021 0.0009 0.0021
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0152 0.015
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0052 0.009 0.0225
Brugia malayi RNA, U transporter 1 0.008 0.0165 0.0415
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0002 0.0004
Echinococcus granulosus carbonyl reductase 1 0.0052 0.009 0.0225
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0152 0.0365
Schistosoma mansoni coup transcription factor 0.0021 0.0009 0.0021
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0152 0.015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0011 0.0029
Brugia malayi MH1 domain containing protein 0.0019 0.0003 0.0006
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.004 0.0089
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0052 0.009 0.0816
Echinococcus multilocularis geminin 0.0537 0.1395 0.3083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0028 0.0071
Loa Loa (eye worm) polyprenyl synthetase 0.0428 0.1102 0.2762
Trichomonas vaginalis ap endonuclease, putative 0.004 0.006 0.0149
Onchocerca volvulus 0.0022 0.0011 0.0023
Mycobacterium ulcerans short chain dehydrogenase 0.3739 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.0267 0.2196
Schistosoma mansoni glutaminase 0.0276 0.0692 0.1735
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0012 0.0031
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0073 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0029
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0052 0.009 0.0088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0144 0.0361
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Mycobacterium ulcerans ketoacyl reductase 0.0052 0.009 0.0088
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0044 0.011
Leishmania major farnesyl pyrophosphate synthase 0.1502 0.3989 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0228 0.057
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0044 0.0097
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1502 0.3989 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Mycobacterium tuberculosis Probable oxidoreductase 0.0052 0.009 0.0088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0009 0.0021
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0028 0.0069
Plasmodium falciparum thioredoxin reductase 0.0052 0.009 0.0209
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0011 0.0104
Schistosoma mansoni zinc finger protein 0.004 0.0058 0.0145
Schistosoma mansoni bromodomain containing protein 0.0125 0.0287 0.0719
Echinococcus granulosus hexokinase type 2 0.0063 0.012 0.03
Schistosoma mansoni biogenic amine (5HT) receptor 0.0375 0.096 0.2407
Brugia malayi Polyprenyl synthetase family protein 0.1502 0.3989 1
Onchocerca volvulus 0.0052 0.009 0.0636
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0064 0.0124 0.0856
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0012 0.0031
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0027 0.0067
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.063 0.1643 0.412
Echinococcus granulosus lamin dm0 0.0057 0.0104 0.0261
Echinococcus multilocularis dna polymerase eta 0.0019 0.0002 0.0004
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0052 0.009 0.0088
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0002 0.0004
Loa Loa (eye worm) oxidoreductase 0.0052 0.009 0.0225
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0009 0.0021
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0286 0.0632
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1502 0.3989 1
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0018 0.0046
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0135 0.034
Loa Loa (eye worm) TAR-binding protein 0.0257 0.0643 0.1612
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0009 0.0022
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0152 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.0187 0.122
Trypanosoma cruzi hexokinase, putative 0.0063 0.012 0.03
Loa Loa (eye worm) oxidoreductase 0.0052 0.009 0.0225
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0004
Plasmodium vivax hexokinase, putative 0.0063 0.012 0.0283
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0052 0.009 0.0199
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0017
Onchocerca volvulus 0.0063 0.012 0.0868
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0018 0.0046
Toxoplasma gondii exonuclease III APE 0.004 0.006 0.0149
Onchocerca volvulus 0.0063 0.012 0.0868
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0027 0.0067
Mycobacterium leprae Probable oxidoreductase 0.0052 0.009 0.0538
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0428 0.1102 0.2762
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0084 0.0211
Entamoeba histolytica short chain dehydrogenase family protein 0.0052 0.009 0.0816
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0018 0.0041
Loa Loa (eye worm) hypothetical protein 0.0075 0.0152 0.0381
Leishmania major dehydrogenase-like protein 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Schistosoma mansoni cpg binding protein 0.0028 0.0026 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0029
Brugia malayi follicle stimulating hormone receptor 0.0227 0.0562 0.1409
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0029
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Echinococcus multilocularis Chromobox protein 3 0.0022 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0021
Echinococcus multilocularis Smad4 0.0035 0.0044 0.0097
Entamoeba histolytica hypothetical protein 0.0022 0.0011 0.0104
Brugia malayi RNA binding protein 0.0257 0.0643 0.1612
Plasmodium vivax glutathione reductase, putative 0.0052 0.009 0.0209
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1502 0.3989 0.3988
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0018 0.0041
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0052 0.009 0.0538
Schistosoma mansoni hexokinase 0.0063 0.012 0.03
Giardia lamblia Short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0187 0.0468
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0207 0.0458
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0028 0.0026 0.0064
Giardia lamblia PHD finger protein 15 0.0028 0.0028 0.0069
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Schistosoma mansoni ap endonuclease 0.004 0.006 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0084 0.0211
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0145 0.0363
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0052 0.009 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0009 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0217 0.0545
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0144 0.0361
Echinococcus granulosus carbonyl reductase 1 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0173 0.0434
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0207 0.0519
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0028 0.0061
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0028 0.0069
Echinococcus granulosus Smad4 0.0035 0.0044 0.011
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Toxoplasma gondii hypothetical protein 0.003 0.0032 0.0081
Loa Loa (eye worm) oxidoreductase 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0098 0.0214 0.0538
Giardia lamblia DINP protein human, muc B family 0.0019 0.0002 0.0004
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1502 0.3989 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Leishmania major hypothetical protein, conserved 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0075 0.0152 0.0381
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.063 0.1643 0.412
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0018 0.0046
Schistosoma mansoni chromobox protein 0.0022 0.0011 0.0029
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0375 0.096 0.2122
Treponema pallidum octaprenyl-diphosphate synthase 0.063 0.1643 1
Echinococcus multilocularis retinol dehydrogenase 13 0.0052 0.009 0.0199
Brugia malayi jmjC domain containing protein 0.0025 0.0018 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0009 0.0021
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1502 0.3989 1
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0011 0.0012
Echinococcus granulosus lamin 0.0057 0.0104 0.0261
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0121 0.0303
Trichomonas vaginalis chromobox protein, putative 0.0022 0.0011 0.0029
Onchocerca volvulus Sepiapterin reductase homolog 0.0052 0.009 0.0636
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0343 0.086
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0018 0.0046
Echinococcus multilocularis retinol dehydrogenase 11 0.0052 0.009 0.0199
Brugia malayi RNA recognition motif domain containing protein 0.0257 0.0643 0.1612
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0207 0.0519
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0084 0.0211
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0135 0.034
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0052 0.009 0.0199
Onchocerca volvulus 0.0086 0.0181 0.1351
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0152 0.0381
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0428 0.1102 0.2762
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0028 0.0026 0.0064
Brugia malayi Retinol dehydrogenase 12 0.0052 0.009 0.0225
Schistosoma mansoni steroid dehydrogenase 0.0052 0.009 0.0225
Onchocerca volvulus Huntingtin homolog 0.0119 0.0271 0.2052
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.0017
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0052 0.009 0.0225
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0152 0.112
Brugia malayi Coelomocyte uptake defective protein 5 0.0072 0.0145 0.0362
Plasmodium falciparum phd finger protein, putative 0.0028 0.0028 0.0053
Onchocerca volvulus 0.0052 0.009 0.0636
Plasmodium vivax steroid dehydrogenase, putative 0.0052 0.009 0.0209
Echinococcus granulosus dnaJ subfamily B 0.0395 0.1013 0.254
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Trypanosoma brucei hexokinase 0.0063 0.012 0.03
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0052 0.009 0.0225
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0428 0.1102 1
Loa Loa (eye worm) heterochromatin protein 1 0.0137 0.0319 0.08
Loa Loa (eye worm) fli-1 protein 0.0219 0.0539 0.1351
Entamoeba histolytica hexokinase 1 0.0063 0.012 0.1085
Schistosoma mansoni tar DNA-binding protein 0.0257 0.0643 0.1612
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0009 0.0019
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0106 0.0104
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0052 0.009 0.0209
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0106 0.0685
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0187 0.0958
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0084 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Brugia malayi Ets-domain containing protein 0.0072 0.0145 0.0363
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Loa Loa (eye worm) hexokinase 0.0063 0.012 0.03
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0113 0.0284
Brugia malayi hexokinase 0.0063 0.012 0.03
Schistosoma mansoni lamin 0.0057 0.0104 0.0261
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0022 0.0011 0.0025
Plasmodium vivax JmjC domain containing protein 0.0025 0.0018 0.0029
Echinococcus granulosus oxidoreductase 0.0052 0.009 0.0225
Schistosoma mansoni chromobox protein 0.0137 0.0319 0.08
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Echinococcus multilocularis hexokinase 0.0063 0.012 0.0264
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0206 0.0504 0.1263
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0002 0.0015
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0022 0.0011 0.0029
Trypanosoma brucei hexokinase 0.0063 0.012 0.03
Echinococcus multilocularis tumor protein p63 0.0669 0.175 0.3867
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0152 0.015
Plasmodium falciparum steroid dehydrogenase, putative 0.0052 0.009 0.0209
Schistosoma mansoni cpg binding protein 0.0033 0.004 0.01
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.0267 0.0266
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0189 0.0458 0.1148
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0109 0.0274
Schistosoma mansoni steroid dehydrogenase 0.0052 0.009 0.0225
Schistosoma mansoni steroid dehydrogenase 0.0052 0.009 0.0225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0333 0.0737
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0052 0.009 0.0225
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0428 0.1102 1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.006 0.0149
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0116 0.029
Brugia malayi PHD-finger family protein 0.005 0.0086 0.0215
Schistosoma mansoni mucolipin 0.0066 0.0128 0.0322
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0428 0.1102 0.2435
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Trypanosoma brucei oxidoreductase-like protein 0.0052 0.009 0.0225
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0022 0.0011 0.0029
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1502 0.3989 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.009 0.0198
Leishmania major hypothetical protein, conserved 0.0025 0.0018 0.0046
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0228 0.057
Echinococcus multilocularis steroid dehydrogenase 0.0052 0.009 0.0199
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.006 0.0058
Schistosoma mansoni steroid dehydrogenase 0.0052 0.009 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0152 0.0381
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0044 0.011
Mycobacterium ulcerans short-chain dehydrogenase 0.0052 0.009 0.0088
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0189 0.0458 0.1013
Schistosoma mansoni hypothetical protein 0.0206 0.0504 0.1263
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Plasmodium vivax hypothetical protein, conserved 0.0052 0.009 0.0209
Entamoeba histolytica hypothetical protein, conserved 0.0052 0.009 0.0816
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0009 0.0021
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0009 0.0021
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0052 0.009 0.0225
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0052 0.009 0.0088
Echinococcus granulosus smad 0.0035 0.0044 0.011
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0052 0.009 0.0088
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0111 0.0278
Brugia malayi Ets-domain containing protein 0.0072 0.0145 0.0363
Loa Loa (eye worm) dehydrogenase 0.0052 0.009 0.0225
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0118 0.0268 0.0672
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0052 0.009 0.0225
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0173 0.1287
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0009 0.0021
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0052 0.009 0.0225
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.006 0.0133
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0139 0.0349
Brugia malayi beta-lactamase family protein 0.0075 0.0152 0.0381
Schistosoma mansoni retinal dehydrogenase 0.0052 0.009 0.0225
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0002 0.0004
Mycobacterium ulcerans ketoacyl reductase 0.0052 0.009 0.0088
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0052 0.009 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0084 0.0211
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0428 0.1102 0.2762
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Schistosoma mansoni smad1 5 8 and 0.0035 0.0044 0.011
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0428 0.1102 0.11
Schistosoma mansoni hypothetical protein 0.0095 0.0207 0.0519
Onchocerca volvulus 0.0039 0.0057 0.0378
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.0267 0.0266
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1502 0.3989 1
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.063 0.1643 0.3633
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0214 0.0538
Onchocerca volvulus 0.0497 0.1288 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0113 0.0283
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0428 0.1102 1
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0052 0.009 0.0538
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0009 0.0021
Echinococcus multilocularis oxidoreductase 0.0052 0.009 0.0199
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.0302 0.0301
Schistosoma mansoni cpg binding protein 0.0033 0.004 0.01
Trypanosoma brucei short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0022 0.0011 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0028 0.0071
Loa Loa (eye worm) hypothetical protein 0.0138 0.0321 0.0806
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Echinococcus multilocularis carbonyl reductase 1 0.0052 0.009 0.0199
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0152 0.0381
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0009 0.0019
Echinococcus granulosus chromobox protein 2 0.0022 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0028 0.0071
Brugia malayi jmjC domain containing protein 0.0153 0.0361 0.0905
Loa Loa (eye worm) hypothetical protein 0.0075 0.0152 0.0381
Echinococcus multilocularis transient receptor potential cation channel 0.0052 0.009 0.0199
Leishmania major hypothetical protein, conserved 0.0052 0.009 0.0225
Echinococcus granulosus intermediate filament protein 0.0057 0.0104 0.0261
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.0217 0.0545
Loa Loa (eye worm) oxidoreductase 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Echinococcus multilocularis musashi 0.0057 0.0104 0.023
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0118 0.0268 0.0592
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0028 0.0026 0.0057
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0152 0.015
Onchocerca volvulus 0.0057 0.0104 0.0749
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Schistosoma mansoni carbonyl reductase 0.0052 0.009 0.0225
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0022 0.0011 0.0029
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0052 0.009 0.0538
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0052 0.009 0.0291
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0084 0.0211
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Loa Loa (eye worm) hypothetical protein 0.0075 0.0152 0.0381
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0187 0.0185
Plasmodium vivax SET domain protein, putative 0.0063 0.0121 0.0287
Schistosoma mansoni tar DNA-binding protein 0.0257 0.0643 0.1612
Brugia malayi nuclear hormone receptor 0.0021 0.0009 0.0021
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Echinococcus multilocularis GPCR, family 2 0.0095 0.0207 0.0458
Loa Loa (eye worm) MH2 domain-containing protein 0.0507 0.1313 0.3291
Loa Loa (eye worm) hypothetical protein 0.0119 0.0271 0.0679
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0207 0.0458
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.0217 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0009 0.0021
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0072 0.0144 0.0811
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1502 0.3989 0.3988
Leishmania major hypothetical protein, conserved 0.0052 0.009 0.0225
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0033 0.0082
Echinococcus granulosus geminin 0.0537 0.1395 0.3497
Leishmania major hypothetical protein, conserved 0.003 0.0031 0.0078
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0018 0.0046
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0052 0.009 0.0225
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0084 0.0211
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0018 0.0046
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.0302 0.2525
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1502 0.3989 0.3988
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0052 0.009 0.0088
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0158 0.0395
Trichomonas vaginalis Heterochromatin protein, putative 0.0022 0.0011 0.0029
Mycobacterium tuberculosis Conserved protein 0.0075 0.0152 0.015
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0144 0.0361
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0189 0.0458 0.1148
Schistosoma mansoni hypothetical protein 0.0095 0.0207 0.0519
Echinococcus granulosus chromobox protein 1 0.0137 0.0319 0.08
Toxoplasma gondii melibiase subfamily protein 0.0103 0.0228 0.057
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0052 0.009 0.0225
Onchocerca volvulus 0.0057 0.0104 0.0749
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0021
Loa Loa (eye worm) hexokinase 0.0039 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0029
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0052 0.009 0.0088
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0152 0.0381
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1702 0.4524 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0052 0.009 0.0088
Schistosoma mansoni hypothetical protein 0.0095 0.0207 0.0519
Loa Loa (eye worm) CHromoDomain protein family member 0.0028 0.0026 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0009 0.0021
Schistosoma mansoni ran 0.0021 0.0007 0.0017
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.006 0.0149
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.006 0.0149
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0084 0.0211
Loa Loa (eye worm) hypothetical protein 0.0095 0.0207 0.0519
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0009 0.0021
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Loa Loa (eye worm) beta-lactamase 0.0075 0.0152 0.0381
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0009 0.0019
Brugia malayi Hexokinase family protein 0.0063 0.012 0.03
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0009 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0257 0.0643 0.1612
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.0562 0.1409
Loa Loa (eye worm) hypothetical protein 0.0085 0.0179 0.0448
Brugia malayi Valyl-tRNA synthetase 0.0022 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0009 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0029
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.009 0.0225
Schistosoma mansoni DNA polymerase eta 0.0019 0.0002 0.0004
Leishmania major hypothetical protein, conserved 0.0052 0.009 0.0225
Echinococcus granulosus hexokinase 0.0063 0.012 0.03
Schistosoma mansoni chromobox protein 0.0137 0.0319 0.08
Loa Loa (eye worm) hypothetical protein 0.0062 0.0117 0.0293
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0009 0.0021
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.006 0.0169
Schistosoma mansoni hypothetical protein 0.0095 0.0207 0.0519
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0072 0.0144 0.0361
Leishmania major polyprenyl synthase, putative 0.063 0.1643 0.412
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0152 0.0381
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0052 0.009 0.0088
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0084 0.0186
Entamoeba histolytica Ran family GTPase 0.0021 0.0007 0.006
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.063 0.1643 0.412
Schistosoma mansoni hypothetical protein 0.0028 0.0028 0.0069
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0009 0.0021
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Mycobacterium ulcerans glutaminase 0.0276 0.0692 0.0691
Brugia malayi Bromodomain containing protein 0.0033 0.004 0.0101
Onchocerca volvulus 0.0052 0.009 0.0636
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.0158 0.1165
Leishmania major pteridine reductase 1 0.0052 0.009 0.0225
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0052 0.009 0.0225
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.006 0.054
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0144 0.0361
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0044 0.011
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0428 0.1102 0.2762
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0009 0.0021
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0032 0.0064
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Onchocerca volvulus Alhambra homolog 0.0028 0.0028 0.015
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0428 0.1102 1
Echinococcus granulosus Chromo domain 0.0022 0.0011 0.0029
Echinococcus multilocularis cpg binding protein 0.0033 0.004 0.0088
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0059 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0021 0.0051
Loa Loa (eye worm) inositol-1 0.0072 0.0144 0.0361
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0018 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0009 0.0021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0139 0.0308
Loa Loa (eye worm) oxidoreductase 0.0052 0.009 0.0225
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0009 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0009 0.0021
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0104 0.0261
Leishmania major DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0018 0.0046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0009 0.0019
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0153 0.0361 0.0798
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0343 0.086
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.006 0.0058
Echinococcus granulosus microtubule associated protein 2 0.1367 0.3624 0.9086
Trypanosoma cruzi short chain dehydrogenase, putative 0.0052 0.009 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0009 0.0021
Schistosoma mansoni steroid dehydrogenase 0.0052 0.009 0.0225
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0301 0.076 0.1904
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0152 0.0381
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0052 0.009 0.0225
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0004
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0152 0.015
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0084 0.0211
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0018 0.0041
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Brugia malayi Inositol-1 0.0072 0.0144 0.0361
Onchocerca volvulus 0.0052 0.009 0.0636
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0072 0.0144 0.0142
Brugia malayi CXXC zinc finger family protein 0.0028 0.0026 0.0065
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0075 0.0152 0.0381
Trypanosoma cruzi hexokinase, putative 0.0063 0.012 0.03
Echinococcus granulosus peregrin 0.0033 0.004 0.0101
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0028 0.0071
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0028 0.0071
Brugia malayi jmjC domain containing protein 0.0025 0.0018 0.0046
Brugia malayi Smad1 0.0035 0.0044 0.011
Mycobacterium ulcerans beta-lactamase 0.0075 0.0152 0.015
Onchocerca volvulus 0.0075 0.0152 0.1122
Mycobacterium tuberculosis Probable dehydrogenase 0.0052 0.009 0.0088
Giardia lamblia Hypothetical protein 0.0052 0.009 0.0225
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0027 0.0059
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0025 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0004
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.009 0.0088
Loa Loa (eye worm) Smad1 0.0035 0.0044 0.011
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0018 0.0029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.006 0.0149
Echinococcus granulosus Chromobox protein 3 0.0022 0.0011 0.0029
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0052 0.009 0.0199
Trypanosoma cruzi ISWI complex protein 0.003 0.0031 0.0078
Schistosoma mansoni chromobox protein 0.0022 0.0011 0.0029
Onchocerca volvulus 0.0098 0.0214 0.161
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1502 0.3989 0.8817
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0046
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0021 0.0051
Brugia malayi chromobox protein homolog 3 0.0077 0.0158 0.0395
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0009 0.0021
Trichomonas vaginalis chromobox protein, putative 0.0137 0.0319 0.08
Loa Loa (eye worm) oxidoreductase 0.0052 0.009 0.0225
Echinococcus multilocularis microtubule associated protein 2 0.1367 0.3624 0.8011
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0018 0.0046
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.009 0.0088
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.0302 0.0301
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0152 0.015
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0012 0.0031
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0084 0.0211
Trichomonas vaginalis ran, putative 0.0021 0.0007 0.0017
Schistosoma mansoni ran 0.0021 0.0007 0.0017
Onchocerca volvulus 0.0052 0.009 0.0636
Echinococcus granulosus hypothetical protein 0.0052 0.009 0.0225
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0052 0.009 0.0225
Schistosoma mansoni short chain dehydrogenase 0.0052 0.009 0.0225
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0428 0.1102 0.275
Brugia malayi oxidoreductase 0.0052 0.009 0.0225
Echinococcus granulosus inositol monophosphatase 1 0.0072 0.0144 0.0361
Onchocerca volvulus 0.0052 0.009 0.0636
Echinococcus multilocularis retinol dehydrogenase 11 0.0052 0.009 0.0199
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1502 0.3989 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.009 0.0088
Brugia malayi dehydrogenases, short chain protein 9 0.0052 0.009 0.0225
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0007 0.0017
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0052 0.009 0.0636
Trypanosoma cruzi polyprenyl synthase, putative 0.063 0.1643 0.412
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0333 0.0836
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0033 0.0072
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0052 0.009 0.0225
Echinococcus granulosus jumonji domain containing protein 0.004 0.0058 0.0145
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0009 0.0021
Trichomonas vaginalis chromobox protein, putative 0.0022 0.0011 0.0029
Entamoeba histolytica hypothetical protein, conserved 0.0052 0.009 0.0816
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0009 0.0021
Mycobacterium tuberculosis Probable oxidoreductase 0.0052 0.009 0.0088

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 422 % Percentage opening of human Maxi-K channel in transfected oocyte cells at 20 uM ChEMBL. 15380205
Relaxation (functional) = 14 % Percentage relaxation of phenylephrine-contracted rabbit corpus cavernosum tissue strips at concentration of 10 uM ChEMBL. 15380205

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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