Detailed information for compound 378334

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2522.71 | Formula: C96H160Na8O48S8
  • H donors: 16 H acceptors: 32 LogP: 3.24 Rotable bonds: 64
    Rule of 5 violations (Lipinski): 4
  • SMILES: [O-]C(=O)CCCCCSCC1O[C@@H]2O[C@@H]3C(CSCCCCCC(=O)[O-])O[C@H]([C@H]([C@@H]3O)O)O[C@@H]3C(CSCCCCCC(=O)[O-])O[C@H]([C@H]([C@@H]3O)O)O[C@@H]3C(CSCCCCCC(=O)[O-])O[C@H]([C@H]([C@@H]3O)O)O[C@@H]3C(O[C@@H](O[C@@H]4C(O[C@@H](O[C@@H]5C(O[C@@H](O[C@@H]6C(O[C@@H](O[C@@H]1[C@H]([C@@H]2O)O)[C@@H](O)[C@@H]6O)CSCCCCCC(=O)[O-])[C@@H](O)[C@@H]5O)CSCCCCCC(=O)[O-])[C@@H](O)[C@@H]4O)CSCCCCCC(=O)[O-])[C@H]([C@@H]3O)O)CSCCCCCC(=O)[O-].[NaH+].[NaH+].[NaH+].[NaH+].[NaH+].[NaH+].[NaH+].[NaH+]
  • InChi: 1S/C96H160O48S8.8Na/c97-57(98)25-9-1-17-33-145-41-49-81-65(113)73(121)89(129-49)138-82-50(42-146-34-18-2-10-26-58(99)100)131-91(75(123)67(82)115)140-84-52(44-148-36-20-4-12-28-60(103)104)133-93(77(125)69(84)117)142-86-54(46-150-38-22-6-14-30-62(107)108)135-95(79(127)71(86)119)144-88-56(48-152-40-24-8-16-32-64(111)112)136-96(80(128)72(88)120)143-87-55(47-151-39-23-7-15-31-63(109)110)134-94(78(126)70(87)118)141-85-53(45-149-37-21-5-13-29-61(105)106)132-92(76(124)68(85)116)139-83-51(130-90(137-81)74(122)66(83)114)43-147-35-19-3-11-27-59(101)102;;;;;;;;/h49-56,65-96,113-128H,1-48H2,(H,97,98)(H,99,100)(H,101,102)(H,103,104)(H,105,106)(H,107,108)(H,109,110)(H,111,112);;;;;;;;/q;8*+1/p-8/t49?,50?,51?,52?,53?,54?,55?,56?,65?,66?,67?,68?,69?,70?,71?,72?,73?,74?,75?,76?,77?,78?,79?,80?,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96?;;;;;;;;/m1......../s1
  • InChiKey: JMOAPXVBAQBBCQ-WWHVALAKSA-F  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii exonuclease III APE 0.0037 0.0093 0.1272
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0016 0.0013 0.0047
Echinococcus granulosus hypothetical protein 0.0016 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0174
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0095 0.0313 0.0375
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0013 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.0909 0.7373
Loa Loa (eye worm) hypothetical protein 0.0095 0.0313 0.254
Echinococcus multilocularis steroid dehydrogenase 0.0016 0.0013 0.0013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0074 0.0598
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0093 0.1308
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0038
Schistosoma mansoni intermediate filament proteins 0.0031 0.0068 0.024
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0447 0.7824
Schistosoma mansoni hypothetical protein 0.0073 0.0231 0.0811
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.0447 0.0535
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0049 0.086
Loa Loa (eye worm) hypothetical protein 0.0062 0.0189 0.1534
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0168 0.0595 0.0712
Echinococcus granulosus WW domain containing oxidoreductase 0.0016 0.0013 0.0015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0076 0.0092
Schistosoma mansoni hypothetical protein 0.0033 0.0076 0.0269
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0125 0.0432 0.0432
Schistosoma mansoni carbonyl reductase 0.0016 0.0013 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0168 0.0595 0.8329
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0016 0.0013 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0339 0.119
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0013 0.0045
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0027 0.0052 0.1156
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0027 0.0052 0.1156
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.0052 0.0703
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0032 0.0074 0.0867
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0032 0.0074 0.0259
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0013 0.0045
Trichomonas vaginalis steroid dehydrogenase, putative 0.0016 0.0013 0.0181
Leishmania major dehydrogenase-like protein 0.0016 0.0013 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0074 0.0598
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0078 0.0275
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0162 0.0572 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.0078 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.002 0.0441
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0194
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.0074 0.091
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0131 0.0452 0.1473
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0032 0.0074 0.1033
Loa Loa (eye worm) hypothetical protein 0.0054 0.0157 0.1275
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Onchocerca volvulus 0.0026 0.0049 0.0661
Schistosoma mansoni smad1 5 8 and 0.0017 0.0015 0.0053
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0027 0.0052 0.1156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0093 0.0291
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.0248 0.087
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.1069
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Echinococcus granulosus potassium voltage gated channel protein 0.0093 0.0307 0.0367
Schistosoma mansoni hypothetical protein 0.0053 0.0152 0.0534
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0032 0.0074 0.0088
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0056 0.0164 0.2703
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0024 0.0255
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0027 0.0052 0.1156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0631 0.8843
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0013 0.0011
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0013 0.0045
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0016 0.0013 0.0058
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0016 0.0013 0.005
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0074 0.0598
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0032 0.0074 0.0973
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0013 0.0011
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Brugia malayi DnaJ domain containing protein 0.0069 0.0216 0.1751
Entamoeba histolytica hypothetical protein 0.0095 0.0313 0.4286
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Leishmania major cytochrome p450-like protein 0.0027 0.0052 0.0142
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0199 0.0714 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0124 0.1006
Brugia malayi Carboxylesterase family protein 0.0078 0.0248 0.2008
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0016 0.0013 0.0174
Brugia malayi MH2 domain containing protein 0.0017 0.0015 0.0122
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0032 0.0074 0.0259
Loa Loa (eye worm) hypothetical protein 0.0102 0.0341 0.2767
Brugia malayi N-terminal motif family protein 0.0207 0.0744 0.6028
Echinococcus granulosus intermediate filament protein 0.0031 0.0068 0.0082
Loa Loa (eye worm) hypothetical protein 0.0105 0.0355 0.2877
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0114 0.0388 0.3147
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0074 0.091
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0032 0.0074 0.0223
Toxoplasma gondii oxidoreductase, putative 0.0016 0.0013 0.005
Entamoeba histolytica hypothetical protein 0.0032 0.0074 0.0867
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0199 0.0714 1
Echinococcus granulosus acetylcholinesterase 0.0078 0.0248 0.0297
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0199 0.0714 0.2348
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0073 0.0231 0.0276
Brugia malayi oxidoreductase 0.0016 0.0013 0.0105
Loa Loa (eye worm) acetyltransferase 0.0143 0.05 0.4056
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0027 0.0052 0.1156
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0013 0.0045
Echinococcus granulosus serine protein kinase ATM 0.0095 0.0313 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0631 0.8841
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0039 0.0099 0.0118
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0093 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0631 0.8843
Loa Loa (eye worm) oxidoreductase 0.0016 0.0013 0.0105
Echinococcus granulosus hypothetical protein 0.0016 0.0013 0.0015
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0027 0.0052 0.0913
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0027 0.0052 0.0913
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0162 0.0572 1
Brugia malayi Muscleblind-like protein 0.0334 0.1234 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0287
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0049 0.086
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0032 0.0074 0.1139
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0112 0.1548
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0049 0.086
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0095 0.0313 0.1056
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0016 0.0013 0.0105
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0078 0.0094
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0016 0.0013 0.005
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0027 0.0052 0.1156
Brugia malayi hypothetical protein 0.0258 0.0942 0.7638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0387 0.5417
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0168 0.0595 0.0595
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0168 0.0595 0.2034
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0016 0.0013 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0396 0.5546
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0216 0.0757
Mycobacterium tuberculosis Probable oxidoreductase 0.0016 0.0013 0.0287
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0124 0.1006
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0093 0.0307 0.2489
Schistosoma mansoni hypothetical protein 0.0027 0.0052 0.0183
Leishmania major short chain dehydrogenase, putative 0.0016 0.0013 0.0011
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Echinococcus multilocularis retinol dehydrogenase 11 0.0016 0.0013 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0068 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0668 0.9356
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0535
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0049 0.0648
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0226
Loa Loa (eye worm) hypothetical protein 0.0207 0.0744 0.6028
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0049 0.0516
Loa Loa (eye worm) Smad1 0.0017 0.0015 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0677 0.9486
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0027 0.0052 0.0913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0387 0.5417
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0447 0.7824
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0189 0.0677 0.2226
Leishmania major cytochrome p450-like protein 0.0045 0.0124 0.0381
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0032 0.0074 0.1033
Echinococcus multilocularis oxidoreductase 0.0016 0.0013 0.0013
Mycobacterium tuberculosis Possible oxidoreductase 0.0016 0.0013 0.0287
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.0447 0.1459
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0032 0.0074 0.0259
Brugia malayi MH1 domain containing protein 0.0017 0.0015 0.0122
Mycobacterium ulcerans dehydrogenase/reductase 0.0016 0.0013 0.0226
Leishmania major phosphatidylinositol kinase, putative 0.0032 0.0074 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0437 0.6128
Echinococcus multilocularis acetylcholinesterase 0.0078 0.0248 0.0248
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0027 0.0052 0.0913
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0189 0.0677 0.9481
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0194
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0078 0.0078
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0112 0.1563
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0398
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0013 0.0181
Leishmania major short chain dehydrogenase/reductase, putative 0.0016 0.0013 0.0011
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0016 0.0013 0.0013
Trypanosoma cruzi target of rapamycin kinase 3 0.0189 0.0677 0.2322
Mycobacterium tuberculosis Probable oxidoreductase 0.0016 0.0013 0.0287
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0032 0.0074 0.1139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0189 0.2652
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0032 0.0074 0.1033
Loa Loa (eye worm) oxidoreductase 0.0016 0.0013 0.0105
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0016 0.0013 0.0105
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0032 0.0074 0.0223
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0013 0.0181
Leishmania major hypothetical protein, conserved 0.0796 0.3009 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0016 0.0013 0.0287
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0078 0.1219
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0194
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0016 0.0013 0.0287
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0027 0.0052 0.0913
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.001 0.0034
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0013 0.0181
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0032 0.0074 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0668 0.9356
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0052 0.0148
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0112 0.1548
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.0339 0.0339
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0714 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0076 0.062
Echinococcus granulosus lysine specific demethylase 5A 0.0125 0.0432 0.0517
Onchocerca volvulus 0.0102 0.0341 0.459
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0447 0.1572
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0016 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0102 0.0341 0.2767
Toxoplasma gondii cytochrome p450 superfamily protein 0.0027 0.0052 0.0647
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0226
Loa Loa (eye worm) phosphatidylinositol 3 0.0168 0.0595 0.482
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0199 0.0714 0.2449
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0124 0.0398
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0168 0.0595 0.8329
Leishmania major hypothetical protein, conserved 0.0016 0.0013 0.0011
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0093 0.0307 0.2489
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0112 0.1813
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0015 0.0122
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0032 0.0074 0.0223
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0013 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0189 0.2652
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0016 0.0013 0.0011
Schistosoma mansoni hypothetical protein 0.0194 0.0695 0.2441
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0168 0.0595 0.8329
Onchocerca volvulus 0.0016 0.0013 0.0174
Schistosoma mansoni voltage-gated potassium channel 0.0093 0.0307 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0313 0.439
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Onchocerca volvulus 0.0024 0.0042 0.0567
Schistosoma mansoni fkbp-rapamycin associated protein 0.0095 0.0313 0.1101
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0641 0.8973
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0074 0.0598
Schistosoma mansoni peptidase Clp (S14 family) 0.0162 0.0572 0.2009
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0099 0.1586
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0016 0.0013 0.0287
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0049 0.086
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0074 0.0598
Mycobacterium tuberculosis Probable dehydrogenase 0.0016 0.0013 0.0287
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0226
Echinococcus granulosus acetylcholinesterase 0.0078 0.0248 0.0297
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.05 0.05
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0032 0.0074 0.0074
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0598
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0013 0.0181
Brugia malayi hypothetical protein 0.0016 0.0013 0.0105
Echinococcus multilocularis GPCR, family 2 0.0033 0.0076 0.0076
Brugia malayi MH2 domain containing protein 0.0017 0.0015 0.0122
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0016 0.0013 0.0181
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0052 0.0148
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0106 0.0357 0.6164
Leishmania major hypothetical protein, conserved 0.0039 0.0099 0.0297
Toxoplasma gondii oxidoreductase, putative 0.0016 0.0013 0.005
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0032 0.0074 0.0259
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0016 0.0013 0.0011
Brugia malayi Cytochrome P450 family protein 0.0067 0.0209 0.1691
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0098 0.1573
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.0078 0.0078
Giardia lamblia Hypothetical protein 0.0032 0.0074 0.0867
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0216 0.0757
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.0339 0.0405
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0088 0.0105
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0032 0.0074 0.0867
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0093 0.1489
Leishmania major hypothetical protein, conserved 0.0016 0.0013 0.0011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0093 0.1489
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0032 0.0074 0.1139
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0027 0.0052 0.1156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0668 0.9356
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0106 0.0357 0.7916
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0015 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0339 0.119
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0099 0.1355
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.2188 0.8354 1
Echinococcus granulosus peptidase Clp S14 family 0.0106 0.0357 0.0428
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0124 0.0398
Schistosoma mansoni smad1 5 8 and 0.0017 0.0015 0.0053
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0032 0.0074 0.091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0398
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0074 0.0598
Toxoplasma gondii carbonyl reductase 1, putative 0.0016 0.0013 0.005
Echinococcus multilocularis Zinc finger, PHD finger 0.0032 0.0074 0.0074
Toxoplasma gondii FATC domain-containing protein 0.0095 0.0313 0.4614
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0013 0.0011
Echinococcus granulosus phd:f box containing protein 0.0033 0.0078 0.0094
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0016 0.0013 0.0226
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.0942 0.1128
Mycobacterium leprae putative cytochrome p450 0.0027 0.0052 0.0703
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0024 0.0531
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0016 0.0013 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0224 0.1813
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0016 0.0013 0.0287
Echinococcus granulosus lamin dm0 0.0031 0.0068 0.0082
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.0341 0.1199
Schistosoma mansoni hypothetical protein 0.0033 0.0076 0.0269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0339 0.119
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0027 0.0052 0.1156
Loa Loa (eye worm) hypothetical protein 0.0334 0.1234 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0125 0.0432 0.0432
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0093 0.0757
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0168 0.0595 0.2089
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0049 0.1088
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0016 0.0013 0.0174
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0093 0.1147
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.2008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0078 0.0634
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0074 0.0214
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0016 0.0013 0.005
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0078 0.0094
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0013 0.0181
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0032 0.0074 0.1033
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0049 0.0398
Entamoeba histolytica hypothetical protein 0.0032 0.0074 0.0867
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0168 0.0595 0.8306
Echinococcus granulosus tar DNA binding protein 0.0069 0.0216 0.0258
Loa Loa (eye worm) hypothetical protein 0.0258 0.0942 0.7638
Echinococcus multilocularis steroid dehydrogenase 0.0016 0.0013 0.0013
Echinococcus multilocularis musashi 0.0031 0.0068 0.0068
Loa Loa (eye worm) dehydrogenase 0.0016 0.0013 0.0105
Onchocerca volvulus 0.0016 0.0013 0.0174
Echinococcus multilocularis smad 0.0017 0.0015 0.0015
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Echinococcus granulosus tumor protein p63 0.0369 0.1368 0.1637
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.1069
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0049 0.086
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.0013 0.0047
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0039 0.0099 0.0099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0095 0.0313 0.254
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0016 0.0013 0.0226
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.0447 0.665
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.035 0.2841
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0013 0.0045
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.0447 0.9908
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0076 0.0092
Echinococcus multilocularis geminin 0.0194 0.0695 0.0695
Loa Loa (eye worm) acetylcholinesterase 1 0.0078 0.0248 0.2008
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0162 0.0572 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0016 0.0013 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0027 0.0052 0.1156
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0013 0.0011
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0093 0.0279
Leishmania major short chain dehydrogenase-like protein 0.0016 0.0013 0.0011
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.0013 0.0013
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0485 0.058
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Loa Loa (eye worm) hypothetical protein 0.0162 0.0572 0.4635
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0016 0.0013 0.0011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.035 0.2841
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0032 0.0074 0.1033
Plasmodium falciparum steroid dehydrogenase, putative 0.0016 0.0013 0.0058
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.0447 0.0447
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.05 0.4056
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0074 0.0867
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0045 0.0124 0.2169
Trichomonas vaginalis protein kinase inhibitor, putative 0.0069 0.0216 0.3027
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0089 0.0291 0.0291
Onchocerca volvulus 0.0031 0.0068 0.0918
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0226
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0199 0.0714 1
Leishmania major hypothetical protein, conserved 0.0016 0.0013 0.0011
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0199 0.0714 0.0714
Onchocerca volvulus 0.0016 0.0013 0.0174
Echinococcus granulosus lamin 0.0031 0.0068 0.0082
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0095 0.0313 0.1056
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0016 0.0013 0.0047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0088 0.0088
Onchocerca volvulus 0.0016 0.0013 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0049 0.0398
Onchocerca volvulus 0.0032 0.0074 0.0991
Loa Loa (eye worm) dehydrogenase 0.0016 0.0013 0.0105
Echinococcus multilocularis dnaJ subfamily C 6 0.0069 0.0216 0.0216
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0016 0.0013 0.0226
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0016 0.0013 0.0181
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0016 0.0013 0.0287
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0016 0.0013 0.0011
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0162 0.0572 0.0684
Leishmania major phosphatidylinositol kinase related protein, putative 0.0032 0.0074 0.0214
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0226
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0287
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0027 0.0052 0.0913
Mycobacterium ulcerans carveol-like dehydrogenase 0.0016 0.0013 0.0226
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0015 0.0053
Schistosoma mansoni hypothetical protein 0.0033 0.0076 0.0269
Loa Loa (eye worm) CYP4Cod1 0.0045 0.0124 0.1006
Leishmania major hypothetical protein, conserved 0.0016 0.0013 0.0011
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0012
Brugia malayi dehydrogenases, short chain protein 9 0.0016 0.0013 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0049 0.0398
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0056 0.0164 0.2745
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0168 0.0595 0.482
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.0013 0.0047
Onchocerca volvulus 0.0016 0.0013 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0677 0.9486
Mycobacterium ulcerans hypothetical protein 0.0026 0.0049 0.086
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0013 0.0013
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0032 0.0074 0.0259
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Schistosoma mansoni lamin 0.0031 0.0068 0.024
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0287
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0074 0.0598
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0013 0.0181
Leishmania major phosphatidylinositol 4-kinase, putative 0.0032 0.0074 0.0214
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0078 0.0238
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0013 0.0011
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0016 0.0013 0.0287
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0032 0.0074 0.1033
Brugia malayi Smad1 0.0017 0.0015 0.0122
Schistosoma mansoni jumonji/arid domain-containing protein 0.0125 0.0432 0.1517
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Loa Loa (eye worm) oxidoreductase 0.0016 0.0013 0.0105
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0078 0.0078
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0074 0.0867
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0099 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0641 0.8973
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0027 0.0052 0.0913
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0199 0.0714 0.2508
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0049 0.0132
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0032 0.0074 0.0867
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.001
Brugia malayi Carboxylesterase family protein 0.0078 0.0248 0.2008
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0099 0.031
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0162 0.0572 0.0572
Schistosoma mansoni smad1 5 8 and 0.0017 0.0015 0.0053
Echinococcus multilocularis Smad4 0.0017 0.0015 0.0015
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.005
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0074 0.0867
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.0013 0.0011
Echinococcus granulosus Smad4 0.0017 0.0015 0.0018
Mycobacterium tuberculosis Probable oxidoreductase 0.0016 0.0013 0.0287
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0032 0.0074 0.0088
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0093 0.1439
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0076 0.0076
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0016 0.0013 0.0047
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0162 0.0572 1
Mycobacterium ulcerans ketoacyl reductase 0.0016 0.0013 0.0226
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0027 0.0052 0.0913
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0016 0.0013 0.0287
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0078 0.0634
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0032 0.0074 0.1033
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0013 0.0013
Mycobacterium ulcerans ketoacyl reductase 0.0016 0.0013 0.0226
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0016 0.0013 0.0013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0095 0.0313 0.254
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0355 0.4972
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0016 0.0013 0.0013
Echinococcus multilocularis microtubule associated protein 2 0.0754 0.2846 0.2846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0668 0.9356
Brugia malayi jmjC domain containing protein 0.0125 0.0432 0.35
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.001 0.001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0032 0.0074 0.1033
Schistosoma mansoni retinal dehydrogenase 0.0016 0.0013 0.0045
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0027 0.0052 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0168 0.0595 0.8329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0668 0.9356
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0049 0.0132
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0088 0.0309
Loa Loa (eye worm) hypothetical protein 0.0073 0.0231 0.1871
Onchocerca volvulus 0.0016 0.0013 0.0174
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0095 0.0313 0.0313
Schistosoma mansoni ap endonuclease 0.0037 0.0093 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0714 1
Echinococcus granulosus geminin 0.0194 0.0695 0.0832
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0013 0.0181
Schistosoma mansoni hypothetical protein 0.0032 0.0074 0.0259
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0032 0.0074 0.0088
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0032 0.0074 0.0223
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0013 0.0011
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0162 0.0572 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0024 0.0255
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0287
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0199 0.0714 0.2449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.002 0.0441
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0062 0.0189 0.0625
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0078 0.0634
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0013 0.0107
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0032 0.0074 0.0973
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0016 0.0013 0.0047
Echinococcus multilocularis 0.0032 0.0074 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.011 0.1545
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0216 0.0757
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0098 0.1215
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.002 0.0441
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0631 0.8843
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0032 0.0074 0.1033
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0016 0.0013 0.0287
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0076 0.062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Echinococcus granulosus dnaJ subfamily C 6 0.0069 0.0216 0.0259
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0016 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0016 0.0013 0.0011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0049 0.0516
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0013 0.0045
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.001 0.0214
Leishmania major pteridine reductase 1 0.0016 0.0013 0.0011
Brugia malayi Trypsin family protein 0.0102 0.0341 0.2767
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0013 0.0107
Leishmania major short chain dehydrogenase/reductase, putative 0.0016 0.0013 0.0011
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0032 0.0074 0.0973
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0016 0.0013 0.0287
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0131 0.0452 0.0452
Leishmania major oxidoreductase-like protein 0.0016 0.0013 0.0011
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0216 0.1747
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.05 0.1758
Entamoeba histolytica hypothetical protein 0.0032 0.0074 0.0867
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.0013 0.0047
Echinococcus multilocularis muscleblind protein 0.0334 0.1234 0.1234
Brugia malayi jmjC domain containing protein 0.0033 0.0078 0.0634
Leishmania major short chain dehydrogenase, putative 0.0016 0.0013 0.0011
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0016 0.0013 0.0045
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0027 0.0052 0.0913
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0287
Loa Loa (eye worm) phosphatidylinositol 3 0.0199 0.0714 0.5787
Schistosoma mansoni cytochrome P450 0.0027 0.0052 0.0183
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0076 0.062
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0095 0.0313 0.1101
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0099 0.031
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0027 0.0052 0.0913
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0068 0.0553
Schistosoma mansoni voltage-gated potassium channel 0.0093 0.0307 0.1079
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0032 0.0074 0.1139
Echinococcus granulosus steroid dehydrogenase 0.0016 0.0013 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0027 0.0052 0.1156
Schistosoma mansoni lamin 0.0031 0.0068 0.024
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0032 0.0074 0.0223
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0027 0.0052 0.0913
Mycobacterium ulcerans short-chain dehydrogenase 0.0016 0.0013 0.0226
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0078 0.0634
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0015 0.0015
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0162 0.0572 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0074 0.0214
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0013 0.0058
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.0339 0.2746
Echinococcus multilocularis retinol dehydrogenase 11 0.0016 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0313 0.439
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0032 0.0074 0.091
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0078 0.0238
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0013 0.0015
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0027 0.0052 0.0913
Plasmodium vivax JmjC domain containing protein 0.0033 0.0078 0.1219
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0049 0.0648
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0016 0.0013 0.0287
Leishmania major hypothetical protein, conserved 0.0033 0.0078 0.0228
Schistosoma mansoni hypothetical protein 0.0069 0.0216 0.0759
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0032 0.0074 0.0867
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0027 0.0052 0.0913
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0093 0.0112
Brugia malayi isocitrate dehydrogenase 0.0016 0.001 0.0078
Trypanosoma cruzi short chain dehydrogenase, putative 0.0016 0.0013 0.0011
Brugia malayi FAT domain containing protein 0.0073 0.0231 0.1871
Schistosoma mansoni hypothetical protein 0.0033 0.0076 0.0269
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0226
Brugia malayi Cytochrome P450 family protein 0.0045 0.0124 0.1006
Brugia malayi MH2 domain containing protein 0.025 0.0909 0.7373
Echinococcus multilocularis serine protein kinase ATM 0.0095 0.0313 0.0313
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Onchocerca volvulus 0.0095 0.0316 0.4247
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0131 0.0452 0.1586
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0027 0.0052 0.0913
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0049 0.086
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0049 0.0516
Trypanosoma cruzi short chain dehydrogenase, putative 0.0016 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0104 0.035 0.2841
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0013 0.0013
Plasmodium vivax steroid dehydrogenase, putative 0.0016 0.0013 0.0058
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0007 0.0008
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0032 0.0074 0.0223
Mycobacterium ulcerans short-chain dehydrogenase 0.0016 0.0013 0.0226
Loa Loa (eye worm) cytochrome P450 0.0027 0.0052 0.0423
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0112 0.0134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0194
Onchocerca volvulus 0.0053 0.0152 0.2045
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0216 0.1747
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0013 0.0011
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0074 0.0867
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0027 0.0052 0.0604
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0216 0.0216
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.001
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2188 0.8354 0.8354
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0093 0.2067
Loa Loa (eye worm) carboxylesterase 0.0078 0.0248 0.2008
Echinococcus multilocularis conserved hypothetical protein 0.0016 0.0013 0.0013
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0131 0.0452 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0093 0.1633
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0016 0.0013 0.0045
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0016 0.0013 0.0226
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0078 0.0275
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.001 0.0078
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0024 0.042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0068 0.0553
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0078 0.0973
Entamoeba histolytica hypothetical protein 0.0032 0.0074 0.0867
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0027 0.0052 0.1156
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0268 0.0979 0.7935
Echinococcus multilocularis retinol dehydrogenase 13 0.0016 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0714 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.005
Echinococcus granulosus microtubule associated protein 2 0.0754 0.2846 0.3407
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0013 0.0045
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0447 0.1572
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0032 0.0074 0.0973
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0032 0.0074 0.0088
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0032 0.0074 0.0223
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.0016 0.0055
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0157 0.0552
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0074 0.0223
Loa Loa (eye worm) phosphatidylinositol kinase 0.0032 0.0074 0.0598
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0106 0.0357 0.7916
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0093 0.0307 0.0367
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0016 0.0013 0.0287
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0032 0.0074 0.1139
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0078 0.0078
Loa Loa (eye worm) RNA binding protein 0.0069 0.0216 0.1747
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0027 0.0052 0.0913
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0105 0.0355 0.5245
Echinococcus multilocularis carboxylesterase 5A 0.0078 0.0248 0.0248
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0093 0.0093
Schistosoma mansoni smad 0.0017 0.0015 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0015 0.0122
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0032 0.0074 0.0074
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0074 0.0867
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Schistosoma mansoni microtubule-associated protein tau 0.0754 0.2846 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0027 0.0052 0.1156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.0339 0.0405
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0016 0.0013 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0433 0.6061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0668 0.9356
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0027 0.0052 0.0913
Loa Loa (eye worm) oxidoreductase 0.0016 0.0013 0.0105
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0099 0.1586
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0013 0.0011
Brugia malayi Dehydrogenases, short chain protein 30 0.0016 0.0013 0.0105
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0226
Brugia malayi MH1 domain containing protein 0.0017 0.0015 0.0122
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0226
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0016 0.0013 0.0181
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Onchocerca volvulus 0.0031 0.0068 0.0918
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0016 0.0013 0.0013
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0032 0.0074 0.0074
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.0013 0.0047
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0076 0.062
Onchocerca volvulus 0.0054 0.0157 0.2115
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0131 0.0452 0.7897
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0016 0.0013 0.0011
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0115 0.0392 0.5424
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.0909 0.7373
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0027 0.0052 0.0148
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0032 0.0074 0.0867
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0016 0.0013 0.0287
Onchocerca volvulus 0.0016 0.0013 0.0174
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0074 0.0598
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0027 0.0052 0.1156
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0093 0.0757
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0074 0.0598
Echinococcus multilocularis 0.0027 0.0052 0.0052
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0078 0.0275
Brugia malayi jmjC domain containing protein 0.0033 0.0078 0.0634
Plasmodium vivax hypothetical protein 0.0032 0.0074 0.1139
Echinococcus multilocularis tumor protein p63 0.0369 0.1368 0.1368
Echinococcus granulosus oxidoreductase 0.0016 0.0013 0.0015
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0098 0.1215
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.0339 0.2746
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0016 0.0013 0.0011
Echinococcus granulosus smad 0.0017 0.0015 0.0018
Schistosoma mansoni hypothetical protein 0.0071 0.0224 0.0786
Echinococcus multilocularis potassium voltage gated channel protein 0.0093 0.0307 0.0307
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0078 0.0275
Mycobacterium ulcerans oxidoreductase 0.0016 0.0013 0.0226
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0099 0.1266
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0074 0.0223
Loa Loa (eye worm) oxidoreductase 0.0016 0.0013 0.0105
Schistosoma mansoni carbonyl reductase 0.0016 0.0013 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0016 0.0013 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0074 0.1033
Loa Loa (eye worm) oxidoreductase 0.0016 0.0013 0.0105
Echinococcus granulosus cytochrome P450 2K1 0.0027 0.0052 0.0063
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.1069
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0073 0.0231 0.0231
Echinococcus multilocularis lamin dm0 0.0031 0.0068 0.0068
Schistosoma mansoni Smad4 0.0017 0.0015 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0194
Toxoplasma gondii target of rapamycin (TOR), putative 0.0187 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Echinococcus granulosus muscleblind protein 0.0334 0.1234 0.1477
Schistosoma mansoni jumonji/arid domain-containing protein 0.0125 0.0432 0.1517
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0013 0.0015
Brugia malayi Isocitrate dehydrogenase 0.0016 0.001 0.0078
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0162 0.0572 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0015 0.0018
Brugia malayi intermediate filament protein 0.0031 0.0068 0.0553
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0016 0.0013 0.0174
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0032 0.0074 0.1033
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0078 0.0275
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0032 0.0074 0.0598
Loa Loa (eye worm) oxidoreductase 0.0016 0.0013 0.0105
Schistosoma mansoni survival motor neuron protein 0.0053 0.0152 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0677 0.9486
Mycobacterium tuberculosis Conserved hypothetical protein 0.0032 0.0074 0.1632
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0016 0.0013 0.0011
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.005
Brugia malayi jmjC domain containing protein 0.0125 0.0432 0.35
Onchocerca volvulus 0.0016 0.0013 0.0174
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0032 0.0074 0.1033
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Echinococcus granulosus retinol dehydrogenase 11 0.0016 0.0013 0.0015
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0078 0.0634
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0162 0.0572 0.854
Mycobacterium ulcerans short-chain dehydrogenase 0.0016 0.0013 0.0226
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0027 0.0052 0.0913
Leishmania major phosphatidylinositol 3-kinase, putative 0.0168 0.0595 0.195
Onchocerca volvulus 0.0032 0.0074 0.0991
Leishmania major hypothetical protein, unknown function 0.0032 0.0074 0.0214
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0068 0.0553
Mycobacterium ulcerans ketoacyl reductase 0.0016 0.0013 0.0226
Schistosoma mansoni hypothetical protein 0.0036 0.0088 0.0309
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0209 0.1691
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0013 0.0015
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0078 0.0078
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0049 0.086
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0027 0.0052 0.1156
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0199 0.0714 1
Schistosoma mansoni hypothetical protein 0.0194 0.0695 0.2441
Brugia malayi hypothetical protein 0.0016 0.0013 0.0105
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0032 0.0074 0.0259
Schistosoma mansoni jumonji domain containing protein 0.0125 0.0432 0.1517
Schistosoma mansoni carbonyl reductase 0.0016 0.0013 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0677 0.9486
Mycobacterium tuberculosis Probable oxidoreductase 0.0016 0.0013 0.0287
Brugia malayi Retinol dehydrogenase 12 0.0016 0.0013 0.0105
Mycobacterium ulcerans short-chain dehydrogenase 0.0016 0.0013 0.0226
Loa Loa (eye worm) oxidoreductase 0.0016 0.0013 0.0105
Mycobacterium ulcerans dehydrogenase 0.0016 0.0013 0.0226
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0027 0.0052 0.0913
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0032 0.0074 0.0598
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0199 0.0714 0.2348
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0049 0.1088
Trypanosoma brucei cytochrome P450, putative 0.0045 0.0124 0.1624
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0051 0.0147 0.195
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0013 0.0045
Entamoeba histolytica protein kinase rad3, putative 0.0095 0.0313 0.4286
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0093 0.1147
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0032 0.0074 0.1139
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0027 0.0052 0.1156
Leishmania major hypothetical protein, conserved 0.0016 0.0013 0.0011
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0032 0.0074 0.1033
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0078 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0231 0.3234
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0076 0.0076
Onchocerca volvulus 0.0016 0.0013 0.0174
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0013 0.0013
Brugia malayi Dehydrogenases, short chain protein 2 0.0016 0.0013 0.0105
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0032 0.0074 0.0259
Brugia malayi dehydrogenases, short chain protein 2 0.0016 0.0013 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0027 0.0052 0.1156
Echinococcus multilocularis muscleblind protein 1 0.0334 0.1234 0.1234
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0152 0.1233
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0074 0.1139
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0032 0.0074 0.0074
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0131 0.0452 0.054
Brugia malayi TAR-binding protein 0.0069 0.0216 0.1747
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0287
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0125 0.0432 0.0517
Leishmania major cytochrome p450-like protein 0.0027 0.0052 0.0142
Brugia malayi cytochrome P450 0.0027 0.0052 0.0423
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0027 0.0052 0.1156
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0199 0.0714 0.5787
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0216 0.0757
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0095 0.0313 0.4286
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0078 0.0094
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0598
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0032 0.0074 0.1033
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0013 0.0011
Giardia lamblia GTOR 0.0199 0.0714 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0162 0.0572 0.854
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0074 0.0598
Toxoplasma gondii hypothetical protein 0.0056 0.0164 0.2344
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0016 0.0013 0.0287
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0095 0.0313 0.4313
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0032 0.0074 0.0074
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0105
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0078 0.0634
Loa Loa (eye worm) DnaJ domain-containing protein 0.0069 0.0216 0.1751
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.2008
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0093 0.1308
Loa Loa (eye worm) hypothetical protein 0.0334 0.1234 1
Mycobacterium ulcerans short-chain type oxidoreductase 0.0016 0.0013 0.0226
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0168 0.0595 0.2034
Mycobacterium tuberculosis Probable oxidoreductase 0.0016 0.0013 0.0287
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0162 0.0572 1
Echinococcus granulosus retinol dehydrogenase 11 0.0016 0.0013 0.0015
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0677 0.9486
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0168 0.0595 0.8306
Brugia malayi jmjC domain containing protein 0.0033 0.0078 0.0634
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0049 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0764 0.2885 1
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0013 0.0011
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0168 0.0595 0.195
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0398
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0032 0.0074 0.0088
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0013 0.0045
Schistosoma mansoni ap endonuclease 0.0037 0.0093 0.0328
Brugia malayi Augmenter of liver regeneration 0.0039 0.0099 0.0801
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0313 0.439
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0027 0.0052 0.0913
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.1069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0074 0.1033
Mycobacterium ulcerans oxidoreductase 0.0016 0.0013 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0631 0.8843
Echinococcus multilocularis lamin 0.0031 0.0068 0.0068
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0032 0.0074 0.1139
Brugia malayi RNA binding protein 0.0069 0.0216 0.1747
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0164 0.2745
Onchocerca volvulus Sepiapterin reductase homolog 0.0016 0.0013 0.0174
Brugia malayi Cytochrome P450 family protein 0.0045 0.0124 0.1006
Echinococcus granulosus carboxylesterase 5A 0.0078 0.0248 0.0297
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0447 0.7824
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0007 0.0007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.0341 0.1199
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0016 0.0013 0.0011
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0013 0.0226
Loa Loa (eye worm) oxidoreductase 0.0016 0.0013 0.0105
Giardia lamblia Phosphatidylinositol 4-kinase 0.0032 0.0074 0.0867
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0216 0.1747
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0013 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0668 0.9356
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0027 0.0052 0.1156
Loa Loa (eye worm) hepatopoietin HPO2 0.0039 0.0099 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0168 0.0595 0.8329
Onchocerca volvulus 0.0016 0.0013 0.0174
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0099 0.1355
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0016 0.0013 0.0015
Echinococcus granulosus GPCR family 2 0.0033 0.0076 0.0092
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0074 0.0598
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0078 0.1041
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0093 0.1189
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0112 0.1563
Loa Loa (eye worm) hypothetical protein 0.0071 0.0224 0.1813
Mycobacterium leprae conserved hypothetical protein 0.0032 0.0074 0.1087
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0016 0.0013 0.0105
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0131 0.0452 0.7897
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0164 0.1476
Brugia malayi Cytochrome P450 family protein 0.0027 0.0052 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0631 0.8841
Brugia malayi Probable ClpP-like protease 0.0162 0.0572 0.4635
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.002 0.0441
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0199 0.0714 0.0854
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0207 0.0744 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0162 0.0572 1
Trypanosoma brucei oxidoreductase-like protein 0.0016 0.0013 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0631 0.8841
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0013 0.0226
Onchocerca volvulus 0.0016 0.0013 0.0174
Leishmania major 3-keto-dihydrosphingosine reductase 0.0016 0.0013 0.0011
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0013 0.0015
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0032 0.0074 0.0088
Echinococcus multilocularis peptidase Clp (S14 family) 0.0106 0.0357 0.0357
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.0942 0.0942
Echinococcus multilocularis acetylcholinesterase 0.0078 0.0248 0.0248
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0013 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0027 0.0052 0.1156
Brugia malayi follicle stimulating hormone receptor 0.0268 0.0979 0.7935
Brugia malayi jmjC domain containing protein 0.0033 0.0078 0.0634
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0216 0.0757
Onchocerca volvulus 0.0016 0.0013 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0387 0.5417
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0015 0.0015
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0032 0.0074 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.0125 0.0432 0.35
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0032 0.0074 0.0223
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0027 0.0052 0.0913
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0131 0.0452 0.366
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0016 0.0013 0.0058
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0016 0.0013 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.0339 0.0339
Brugia malayi hypothetical protein 0.0036 0.0088 0.0712
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0027 0.0052 0.1156
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.035 0.2841
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0013 0.0181
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.001 0.001

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 7 uM In vitro reversal activity versus ~90% block by rocuronium in isolated mouse hemidiaphragm,expressed as effective conc. ChEMBL. 11960492
ED50 (functional) = 0.74 uM kg-1 In vivo reversal activity versus ~90% block by rocuronium in guinea pig ChEMBL. 11960492
Max reversal (functional) = 78.4 % In vivo reversal activity versus ~90% block by rocuronium in guinea pig, expressed as % of maximum reversal at 2.5 umol/kg conc. ChEMBL. 11960492
Max reversal (functional) = 81.7 % In vitro reversal activity versus ~90% block by rocuronium in isolated mouse hemidiaphragm,expressed as % of maximum reversal at 12.6 uM conc. ChEMBL. 11960492

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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