Detailed information for compound 507575

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 469.578 | Formula: C28H31N5O2
  • H donors: 1 H acceptors: 2 LogP: 4.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(O/N=C(/c1ccc2c(c1)c1c3CNC(=O)c3c3c(c1n2C(C)C)CCc1c3cn(n1)C)\C)C
  • InChi: 1S/C28H31N5O2/c1-14(2)33-23-10-7-17(16(5)31-35-15(3)4)11-19(23)25-20-12-29-28(34)26(20)24-18(27(25)33)8-9-22-21(24)13-32(6)30-22/h7,10-11,13-15H,8-9,12H2,1-6H3,(H,29,34)/b31-16+
  • InChiKey: WZPJVJBPNASYEY-WCMJOSRZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TEK tyrosine kinase, endothelial Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0004
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0135 0.0162
Toxoplasma gondii beta tubulin 0.0529 0.3191 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.0135 0.0422
Schistosoma mansoni apoferritin-2 0.0157 0.088 0.1058
Leishmania major beta tubulin 0.0529 0.3191 1
Leishmania major hypothetical protein, conserved 0.0254 0.1483 0.4646
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0008
Brugia malayi PHD-finger family protein 0.0028 0.0079 0.0246
Onchocerca volvulus Protein ultraspiracle homolog 0.0048 0.0201 0.0715
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0664 0.0798
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0095 0.0114
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0214 0.0257
Schistosoma mansoni tubulin subunit beta 0.0529 0.3191 0.3835
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0341 0.2023 0.6338
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0201 0.0631
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0046 0.0297
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0235 0.1363 0.9183
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.2721 0.3269
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0012 0.0063
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0012 0.0037
Echinococcus granulosus tubulin alpha 3 chain 0.0398 0.2382 0.2862
Loa Loa (eye worm) alpha-tubulin 0.0398 0.2382 0.4118
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0046 0.0297
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0341 0.2023 0.6338
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0067 0.0319 0.0383
Giardia lamblia Alpha-tubulin 0.0398 0.2382 0.7462
Brugia malayi Tubulin alpha-2 chain 0.0398 0.2382 0.7462
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0046 0.0145
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0139 0.0436
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0022 0.0037 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0197 0.113 0.1358
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0008
Trypanosoma cruzi epsilon tubulin, putative 0.0325 0.1922 0.6023
Echinococcus granulosus ferritin 0.0157 0.088 0.1058
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0243 0.0292
Leishmania major beta tubulin 0.0529 0.3191 1
Schistosoma mansoni cytochrome P450 0.0018 0.0012 0.0014
Schistosoma mansoni alpha tubulin 0.0398 0.2382 0.2862
Echinococcus multilocularis peroxisome assembly protein 26 0.0398 0.2382 0.2862
Trypanosoma cruzi zeta tubulin, putative 0.0421 0.2525 0.7911
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.003 0.0036
Trypanosoma brucei epsilon tubulin 0.0325 0.1922 0.6023
Trichomonas vaginalis D-aminoacylase, putative 0.0254 0.1483 0.4646
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0046 0.0235
Onchocerca volvulus 0.0059 0.0269 0.0957
Loa Loa (eye worm) hypothetical protein 0.0067 0.0319 0.0551
Loa Loa (eye worm) tubulin alpha-2 chain 0.0398 0.2382 0.4118
Entamoeba histolytica hypothetical protein 0.0148 0.0822 0.2574
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.0386 0.0667
Entamoeba histolytica tubulin alpha chain, putative 0.0398 0.2382 0.7462
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0003 0.0008
Echinococcus multilocularis mitogen activated protein kinase 3 0.0202 0.1162 0.1396
Giardia lamblia Kinase, CMGC MAPK 0.0202 0.1162 0.3639
Giardia lamblia Epsilon tubulin 0.0164 0.092 0.2883
Echinococcus granulosus FTZ F1 alpha 0.0048 0.0201 0.0242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1776 0.5564
Trypanosoma brucei alpha tubulin 0.0398 0.2382 0.7462
Echinococcus granulosus tubulin alpha 0.0297 0.1753 0.2106
Echinococcus multilocularis tyrosine protein kinase Src42A 0.005 0.0214 0.0257
Plasmodium falciparum glutathione reductase 0.0046 0.0191 0.0599
Schistosoma mansoni hypothetical protein 0.0148 0.0822 0.0987
Schistosoma mansoni hypothetical protein 0.0129 0.0703 0.0845
Plasmodium falciparum thioredoxin reductase 0.0016 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0341 0.2023 0.3497
Echinococcus multilocularis epidermal growth factor receptor 0.0256 0.1493 0.1794
Entamoeba histolytica hypothetical protein 0.0148 0.0822 0.2574
Echinococcus granulosus histone lysine methyltransferase setb 0.0094 0.0489 0.0588
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0003 0.0008
Trypanosoma cruzi ISWI complex protein 0.0032 0.0099 0.0312
Brugia malayi ecdysone receptor 0.0023 0.0043 0.0136
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0094 0.0489 0.0588
Echinococcus granulosus tyrosine protein kinase Lyn 0.0052 0.0229 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0197 0.113 0.1358
Entamoeba histolytica tubulin family protein 0.0529 0.3191 1
Trypanosoma brucei protein kinase, putative 0.0202 0.1162 0.3639
Onchocerca volvulus 0.0023 0.0046 0.0165
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0003 0.0008
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0136 0.0751 0.2353
Echinococcus granulosus tubulin alpha 1C chain 0.0398 0.2382 0.2862
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0139 0.0436
Echinococcus multilocularis tubulin alpha chain 0.0398 0.2382 0.2862
Loa Loa (eye worm) beta-tubulin 0.0529 0.3191 0.5518
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.014 0.0169
Schistosoma mansoni tubulin subunit beta 0.0529 0.3191 0.3835
Loa Loa (eye worm) alpha-tubulin 0.0398 0.2382 0.4118
Trypanosoma brucei beta tubulin 0.0529 0.3191 1
Brugia malayi Tubulin beta-1 chain 0.0529 0.3191 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0003 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0022 0.0037 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1776 0.5564
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0135 0.0894
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0012 0.0063
Leishmania major hypothetical protein, conserved 0.0032 0.0099 0.0312
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0003 0.0008
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0012 0.0063
Brugia malayi nuclear hormone receptor 0.0023 0.0043 0.0136
Echinococcus granulosus epidermal growth factor receptor 0.0172 0.0974 0.1171
Schistosoma mansoni alpha tubulin 0.0398 0.2382 0.2862
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Schistosoma mansoni retinoic acid receptor RXR 0.0048 0.0201 0.0242
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0048 0.0201 0.0242
Echinococcus granulosus tyrosine protein kinase Src42A 0.005 0.0214 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0751 0.2353
Echinococcus multilocularis dna polymerase kappa 0.0037 0.0135 0.0162
Brugia malayi tubulin alpha-2 chain 0.0398 0.2382 0.7462
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0046 0.0145
Loa Loa (eye worm) hypothetical protein 0.0055 0.0243 0.042
Brugia malayi beta-lactamase family protein 0.0254 0.1483 0.4646
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0202 0.1162 0.3639
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.1066 0.3341
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0139 0.0436
Trypanosoma brucei tubulin gamma chain 0.0325 0.1925 0.603
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0046 0.0297
Echinococcus multilocularis ferritin 0.0157 0.088 0.1058
Entamoeba histolytica tubulin alpha-1 chain 0.0398 0.2382 0.7462
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0022 0.0037 0.0045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.0386 0.1209
Entamoeba histolytica G protein alpha subunit, putative 0.0022 0.0037 0.0116
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0017
Brugia malayi PHD-finger family protein 0.0052 0.0223 0.07
Echinococcus multilocularis carbonic anhydrase II 0.0437 0.2621 0.315
Trypanosoma brucei alpha tubulin 0.0398 0.2382 0.7462
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0187 0.1066 0.1281
Entamoeba histolytica hypothetical protein 0.0148 0.0822 0.2574
Schistosoma mansoni ferritin light chain 0.0157 0.088 0.1058
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0214 0.0257
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0012 0.0012
Brugia malayi ecdysteroid receptor 0.0048 0.0201 0.0631
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0561 0.3735
Echinococcus multilocularis tubulin gamma 1 chain 0.0325 0.1925 0.2313
Brugia malayi Thioredoxin reductase 0.0046 0.0191 0.0599
Loa Loa (eye worm) hypothetical protein 0.0254 0.1483 0.2564
Echinococcus multilocularis expressed protein 0.0022 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0018
Giardia lamblia Beta tubulin 0.0529 0.3191 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0048 0.0201 0.0715
Brugia malayi hypothetical protein 0.0122 0.0662 0.2074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0003 0.0008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0365 0.0439
Loa Loa (eye worm) hypothetical protein 0.0077 0.0379 0.0654
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0048 0.0201 0.0348
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0022 0.0037 0.0116
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0022 0.0037 0.0045
Onchocerca volvulus Bile acid receptor homolog 0.0048 0.0201 0.0715
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.006 0.0189
Leishmania major DNA polymerase eta, putative 0.0062 0.0288 0.0902
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0079 0.0397 0.0686
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0079 0.0136
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.048 0.0576
Leishmania major beta tubulin 0.0529 0.3191 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0269 0.0324
Schistosoma mansoni tubulin subunit epsilon 0.0325 0.1922 0.231
Schistosoma mansoni tubulin subunit alpha 0.0398 0.2382 0.2862
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0214 0.0257
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0022 0.0037 0.0045
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.0386 0.1209
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0043 0.0052
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0022 0.0037 0.0045
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0048 0.0201 0.0242
Plasmodium falciparum tubulin beta chain 0.0529 0.3191 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0048 0.0201 0.0242
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0048 0.0201 0.0348
Loa Loa (eye worm) hypothetical protein 0.0148 0.0822 0.1421
Plasmodium vivax hypothetical protein, conserved 0.0254 0.1483 0.4646
Trichomonas vaginalis tubulin alpha chain, putative 0.0529 0.3191 1
Schistosoma mansoni hypothetical protein 0.0043 0.0168 0.0202
Echinococcus multilocularis 0.0076 0.0378 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Leishmania major beta tubulin 0.0529 0.3191 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0201 0.0348
Onchocerca volvulus 0.0023 0.0043 0.0154
Schistosoma mansoni tubulin subunit alpha 0.0136 0.0751 0.0902
Brugia malayi Cytochrome P450 family protein 0.0018 0.0012 0.0037
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.1066 0.3341
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0012 0.0037
Onchocerca volvulus 0.0254 0.1483 0.527
Trichomonas vaginalis tubulin alpha chain, putative 0.0297 0.1753 0.5492
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0365 0.0439
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0128 0.04
Loa Loa (eye worm) beta-lactamase 0.0254 0.1483 0.2564
Loa Loa (eye worm) hypothetical protein 0.0048 0.0201 0.0348
Mycobacterium tuberculosis Probable lipase LipE 0.0254 0.1483 0.1483
Loa Loa (eye worm) hypothetical protein 0.0262 0.1533 0.2651
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0139 0.0436
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0079 0.0094
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0135 0.0422
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0135 0.0162
Schistosoma mansoni tubulin subunit beta 0.0136 0.0751 0.0902
Echinococcus multilocularis Tubulin beta 2C chain 0.0529 0.3191 0.3835
Loa Loa (eye worm) hypothetical protein 0.0084 0.0427 0.0739
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0043 0.0052
Brugia malayi Bromodomain containing protein 0.0155 0.0869 0.2721
Leishmania major beta tubulin 0.0529 0.3191 1
Echinococcus multilocularis zinc finger protein 0.0041 0.0155 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0254 0.1483 0.4646
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.005 0.0214 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0063 0.0196
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0201 0.0242
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0012 0.0012
Plasmodium vivax tubulin epsilon chain, putative 0.0325 0.1922 0.6023
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0484 0.1518
Trichomonas vaginalis tubulin gamma chain, putative 0.0325 0.1925 0.603
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.0386 0.1209
Leishmania major beta tubulin 0.0529 0.3191 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.048 0.0576
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0017
Loa Loa (eye worm) tubulin alpha chain 0.0398 0.2382 0.4118
Toxoplasma gondii alpha-tubulin I, putative 0.0398 0.2382 0.7462
Schistosoma mansoni GTP-binding protein alpha subunit 0.0022 0.0037 0.0045
Echinococcus multilocularis lamin 0.0027 0.0073 0.0088
Trypanosoma cruzi epsilon tubulin, putative 0.0325 0.1922 0.6023
Schistosoma mansoni hypothetical protein 0.0031 0.0095 0.0114
Echinococcus multilocularis lamin dm0 0.0027 0.0073 0.0088
Loa Loa (eye worm) inositol-1 0.0038 0.0139 0.0241
Schistosoma mansoni tyrosine kinase 0.005 0.0214 0.0257
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0022 0.0037 0.0045
Schistosoma mansoni hypothetical protein 0.0031 0.0095 0.0114
Schistosoma mansoni zinc finger protein 0.0032 0.0099 0.012
Schistosoma mansoni ap endonuclease 0.0078 0.0386 0.0464
Loa Loa (eye worm) hypothetical protein 0.0048 0.0201 0.0348
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0043 0.0136
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0135 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0201 0.0242
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0043 0.0136
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0046 0.0186 0.0224
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0095 0.0164
Loa Loa (eye worm) hypothetical protein 0.0048 0.0201 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Echinococcus granulosus survival motor neuron protein 1 0.0469 0.282 0.3388
Schistosoma mansoni cellular tumor antigen P53 0.0148 0.0822 0.0988
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0022 0.0037 0.0116
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0214 0.0257
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0139 0.0923
Echinococcus granulosus beta tubulin 0.0529 0.3191 0.3835
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0254 0.1483 0.1483
Schistosoma mansoni zinc finger protein 0.0041 0.0155 0.0186
Schistosoma mansoni tyrosine kinase 0.0166 0.0938 0.1127
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0017 0.0006 0.0018
Brugia malayi Tubulin beta chain 0.0161 0.0904 0.2834
Plasmodium vivax tubulin gamma chain, putative 0.0325 0.1925 0.603
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0168 0.0291
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0003
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0022 0.0037 0.0045
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0205 0.1179 0.1416
Brugia malayi alpha-tubulin 0.0398 0.2382 0.7462
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.012 0.0793
Trypanosoma cruzi beta tubulin, putative 0.0529 0.3191 1
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0022 0.0037 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.1066 0.1281
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0191 0.0191
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.1776 0.5564
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0254 0.1483 0.4646
Leishmania major beta tubulin 0.0529 0.3191 1
Echinococcus multilocularis tubulin alpha chain 0.0398 0.2382 0.2862
Schistosoma mansoni hypothetical protein 0.002 0.003 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0202 0.1162 0.3639
Echinococcus granulosus roundabout 2 0.0022 0.004 0.0048
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0008
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0022 0.0037 0.0045
Schistosoma mansoni DNA polymerase eta 0.0062 0.0288 0.0346
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0012 0.0021
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0512 0.1603
Trypanosoma brucei alpha tubulin 0.0398 0.2382 0.7462
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0022 0.0037 0.0064
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0003 0.0008
Schistosoma mansoni hypothetical protein 0.0028 0.0079 0.0094
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0043 0.0136
Giardia lamblia Beta tubulin 0.0529 0.3191 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0095 0.0298
Onchocerca volvulus 0.0022 0.0037 0.0132
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0512 0.0884
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.0135 0.0422
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0022 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0254 0.1483 0.2564
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0022 0.0037 0.0116
Onchocerca volvulus Alhambra homolog 0.0028 0.0079 0.0279
Trichomonas vaginalis D-aminoacylase, putative 0.0254 0.1483 0.4646
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0095 0.0114
Entamoeba histolytica hypothetical protein 0.0148 0.0822 0.2574
Echinococcus multilocularis tyrosine protein kinase HCK 0.0041 0.0158 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0201 0.0242
Echinococcus granulosus zinc finger protein 0.0041 0.0155 0.0186
Loa Loa (eye worm) TK protein kinase 0.0041 0.0158 0.0273
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0022 0.0037 0.0116
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0043 0.0052
Echinococcus granulosus peregrin 0.0033 0.0109 0.0131
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0022 0.0037 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1776 0.5564
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.0386 0.2589
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0004
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0022 0.0037 0.0116
Brugia malayi Doublecortin family protein 0.002 0.003 0.0093
Onchocerca volvulus Huntingtin homolog 0.0122 0.0662 0.2352
Plasmodium falciparum carbonic anhydrase 0.0341 0.2023 0.6338
Giardia lamblia Kinase, PLK 0.0187 0.1066 0.3341
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.1776 1
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0201 0.0242
Echinococcus multilocularis tubulin alpha chain 0.0398 0.2382 0.2862
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0187 0.1066 0.1844
Schistosoma mansoni hypothetical protein 0.1353 0.8322 1
Schistosoma mansoni zinc finger protein 0.0023 0.0043 0.0052
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0022 0.0037 0.0045
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.0288 0.0902
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0104
Plasmodium falciparum tubulin gamma chain 0.0325 0.1925 0.603
Echinococcus granulosus dna polymerase eta 0.0062 0.0288 0.0346
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0437 0.2621 0.315
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0003 0.0008
Schistosoma mansoni peptidase Clp (S14 family) 0.0235 0.1363 0.1637
Trichomonas vaginalis tubulin alpha chain, putative 0.0161 0.0904 0.2834
Onchocerca volvulus 0.002 0.003 0.0106
Onchocerca volvulus 0.0148 0.0822 0.2921
Loa Loa (eye worm) hypothetical protein 0.0237 0.138 0.2385
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.2721 0.3269
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0043 0.0052
Trypanosoma brucei beta tubulin 0.0529 0.3191 1
Echinococcus granulosus alpha tubulin 0.0398 0.2382 0.2862
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0022 0.0037 0.0116
Toxoplasma gondii hypothetical protein 0.0341 0.2023 0.6338
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0012 0.0012
Echinococcus granulosus epidermal growth factor receptor 0.0256 0.1493 0.1794
Leishmania major carbonic anhydrase-like protein 0.0437 0.2621 0.8213
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0254 0.1483 0.2564
Schistosoma mansoni lamin 0.0027 0.0073 0.0088
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0003 0.0008
Brugia malayi Bromodomain containing protein 0.0033 0.0109 0.0342
Brugia malayi hypothetical protein 0.0025 0.006 0.0189
Echinococcus multilocularis beta LACTamase domain containing family member 0.0254 0.1483 0.1782
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0288 0.0902
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0012 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.1066 0.3341
Echinococcus granulosus mitogen activated protein kinase 3 0.0202 0.1162 0.1396
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0012 0.0037
Leishmania major beta tubulin 0.0529 0.3191 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0004
Echinococcus granulosus tyrosine protein kinase Blk 0.0046 0.0186 0.0224
Echinococcus granulosus insulin receptor 0.0219 0.1267 0.1522
Onchocerca volvulus 0.0027 0.0073 0.0259
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0269 0.0324
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0237 0.138 0.4323
Echinococcus granulosus ecdysone induced protein 78C 0.0048 0.0201 0.0242
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0235 0.1363 0.427
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0012 0.0012
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0022 0.0037 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0048 0.0201 0.0631
Echinococcus multilocularis roundabout 2 0.0022 0.004 0.0048
Trypanosoma brucei hypothetical protein, conserved 0.0254 0.1483 0.4646
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0187 0.1069 0.1848
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0043 0.0052
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0135 0.0422
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0398 0.2382 0.7462
Echinococcus granulosus tumor protein p63 0.101 0.6185 0.7431
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.014 0.0169
Schistosoma mansoni hypothetical protein 0.0018 0.0012 0.0014
Echinococcus granulosus tubulin alpha chain 0.0398 0.2382 0.2862
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Schistosoma mansoni hypothetical protein 0.1353 0.8322 1
Entamoeba histolytica protein kinase, putative 0.0041 0.0158 0.0495
Loa Loa (eye worm) tubulin beta-4 chain 0.0529 0.3191 0.5518
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0191 0.0599
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.006 0.0072
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0504 0.3039 0.5254
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0235 0.1363 0.1637
Echinococcus granulosus tubulin alpha chain 0.0398 0.2382 0.2862
Loa Loa (eye worm) glutathione reductase 0.0046 0.0191 0.0331
Echinococcus multilocularis tar DNA binding protein 0.0197 0.113 0.1358
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0043 0.0136
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0048 0.0201 0.0348
Schistosoma mansoni microtubule-associated protein tau 0.0701 0.4267 0.5128
Echinococcus multilocularis Tubulin beta 2C chain 0.0529 0.3191 0.3835
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0048 0.0201 0.0631
Echinococcus multilocularis tumor protein p63 0.101 0.6185 0.7431
Brugia malayi Cytochrome P450 family protein 0.0035 0.012 0.0376
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0043 0.0052
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.1066 0.3341
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.0135 0.0422
Echinococcus granulosus tyrosine protein kinase Src64B 0.005 0.0214 0.0257
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.1351 0.2336
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0043 0.0052
Trichomonas vaginalis tubulin alpha chain, putative 0.0161 0.0904 0.2834
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.003 0.0093
Giardia lamblia Alpha-tubulin 0.0398 0.2382 0.7462
Schistosoma mansoni tyrosine kinase 0.0166 0.0938 0.1127
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0262 0.1533 0.4804
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0043 0.0075
Schistosoma mansoni tubulin subunit delta 0.0136 0.0751 0.0902
Leishmania major pantothenate kinase subunit, putative 0.0017 0.0006 0.0018
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0202 0.0242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0504 0.3039 0.3652
Schistosoma mansoni tar DNA-binding protein 0.0197 0.113 0.1358
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0214 0.0257
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Echinococcus granulosus dna polymerase kappa 0.0037 0.0135 0.0162
Brugia malayi Cytochrome P450 family protein 0.0035 0.012 0.0376
Brugia malayi protein-tyrosine kinase 0.0046 0.0186 0.0584
Leishmania major DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0051
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0043 0.0052
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0003 0.0008
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0262 0.1533 0.2651
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0022 0.0037 0.0045
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0135 0.0233
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.0386 0.1209
Toxoplasma gondii beta-tubulin, putative 0.0529 0.3191 1
Brugia malayi hypothetical protein 0.002 0.003 0.0093
Leishmania major gamma-tubulin 0.0325 0.1925 0.603
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0307 0.1812 0.5677
Brugia malayi Bromodomain containing protein 0.0079 0.0396 0.124
Echinococcus granulosus GPCR family 2 0.0031 0.0095 0.0114
Trichomonas vaginalis CMGC family protein kinase 0.0202 0.1162 0.3639
Schistosoma mansoni nuclear receptor 0.0023 0.0043 0.0052
Treponema pallidum NADH oxidase 0.0016 0.0003 0.0014
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0012 0.0012
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0012 0.0014
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0164 0.092 0.2883
Brugia malayi Steroid receptor seven-up type 2 0.0048 0.0201 0.0631
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0186 0.0224
Trypanosoma brucei cytochrome P450, putative 0.0035 0.012 0.0376
Schistosoma mansoni inositol monophosphatase 0.0038 0.0139 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0043 0.0052
Schistosoma mansoni tyrosine kinase 0.0166 0.0938 0.1127
Mycobacterium ulcerans hypothetical protein 0.0023 0.0046 0.0297
Schistosoma mansoni cell adhesion molecule 0.0019 0.0022 0.0027
Plasmodium vivax SET domain protein, putative 0.0059 0.0269 0.0844
Mycobacterium ulcerans cell division protein FtsZ 0.0136 0.0751 0.5055
Treponema pallidum bacterioferrin (TpF1) 0.0157 0.088 0.4957
Schistosoma mansoni lipoxygenase 0.0086 0.0435 0.0522
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.006 0.0104
Brugia malayi Probable ClpP-like protease 0.0235 0.1363 0.427
Echinococcus multilocularis tubulin alpha 0.0297 0.1753 0.2106
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.001 0.0031
Echinococcus multilocularis tubulin alpha chain 0.0398 0.2382 0.2862
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0202 0.0242
Loa Loa (eye worm) hypothetical protein 0.0341 0.2023 0.3497
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0114 0.0697
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0254 0.1483 0.1483
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0437 0.2621 0.4532
Onchocerca volvulus 0.0096 0.0497 0.1768
Schistosoma mansoni tubulin subunit alpha 0.0398 0.2382 0.2862
Toxoplasma gondii exonuclease III APE 0.0078 0.0386 0.1209
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0046 0.0235
Loa Loa (eye worm) DR-78 0.0023 0.0043 0.0075
Brugia malayi Pre-SET motif family protein 0.0411 0.246 0.7709
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0751 0.2353
Loa Loa (eye worm) hypothetical protein 0.0098 0.0512 0.0884
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0202 0.1162 0.3639
Trypanosoma brucei zeta tubulin, putative 0.0421 0.2525 0.7911
Echinococcus granulosus tubulin alpha chain 0.0398 0.2382 0.2862
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0205 0.1179 0.1416
Echinococcus granulosus tyrosine protein kinase HCK 0.0041 0.0158 0.019
Loa Loa (eye worm) tubulin beta chain 0.0529 0.3191 0.5518
Echinococcus granulosus muscleblind protein 0.0151 0.0839 0.1008
Trypanosoma cruzi alpha tubulin, putative 0.0398 0.2382 0.7462
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0561 0.0561
Mycobacterium tuberculosis Conserved protein 0.0254 0.1483 0.1483
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0104
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.0818 0.5477
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.113 0.1954
Echinococcus granulosus tubulin epsilon chain 0.0325 0.1922 0.231
Leishmania major beta tubulin 0.0529 0.3191 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.1776 0.5564
Schistosoma mansoni hypothetical protein 0.0096 0.0497 0.0598
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0048 0.0201 0.0631
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0139 0.0436
Onchocerca volvulus 0.0167 0.094 0.3339
Schistosoma mansoni steroid hormone receptor ad4bp 0.0048 0.0201 0.0242
Loa Loa (eye worm) BEN-1 protein 0.0529 0.3191 0.5518
Mycobacterium ulcerans beta-lactamase 0.0254 0.1483 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0048 0.0201 0.0242
Toxoplasma gondii thioredoxin reductase 0.0046 0.0191 0.0599
Schistosoma mansoni coup transcription factor 0.0048 0.0201 0.0242
Trichomonas vaginalis tubulin beta chain, putative 0.0398 0.2382 0.7462
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0095 0.0114
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0046 0.0145
Trypanosoma brucei beta tubulin 0.0529 0.3191 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0202 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0048 0.0201 0.0631
Brugia malayi RNA binding protein 0.0197 0.113 0.354
Loa Loa (eye worm) TAR-binding protein 0.0197 0.113 0.1954
Loa Loa (eye worm) G protein alpha subunit 3 0.0022 0.0037 0.0064
Brugia malayi TAR-binding protein 0.0197 0.113 0.354
Echinococcus granulosus neuropeptide s receptor 0.0453 0.2721 0.3269
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.003 0.0036
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0235 0.1363 0.1637
Brugia malayi beta-lactamase 0.0254 0.1483 0.4646
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.1066 0.3341
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.001 0.0031
Plasmodium falciparum LCCL domain-containing protein 0.002 0.003 0.0093
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0048 0.0201 0.0242
Echinococcus granulosus carbonic anhydrase 0.0341 0.2023 0.2431
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0635 0.4235
Echinococcus multilocularis Tubulin beta 2C chain 0.0529 0.3191 0.3835
Leishmania major DNA polymerase eta, putative 0.0036 0.0128 0.04
Loa Loa (eye worm) hypothetical protein 0.0048 0.0202 0.0348
Trypanosoma cruzi hypothetical protein, conserved 0.0254 0.1483 0.4646
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Schistosoma mansoni apoferritin-2 0.0157 0.088 0.1058
Leishmania major delta tubulin, putative 0.0307 0.1812 0.5677
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0235 0.1363 0.9188
Loa Loa (eye worm) carbonic anhydrase 3 0.0437 0.2621 0.4532
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0012 0.0037
Plasmodium vivax tubulin alpha chain, putative 0.0398 0.2382 0.7462
Loa Loa (eye worm) tubulin beta-2A chain 0.0529 0.3191 0.5518
Onchocerca volvulus Tyrosine kinase homolog 0.0175 0.0994 0.3532
Mycobacterium tuberculosis Probable esterase LipL 0.0254 0.1483 0.1483
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0635 0.0635
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.001 0.0051
Loa Loa (eye worm) doublecortin family protein 0.002 0.003 0.0051
Schistosoma mansoni tyrosine kinase 0.0219 0.1267 0.1522
Brugia malayi Tubulin alpha-2 chain 0.0398 0.2382 0.7462
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0406 0.2284
Schistosoma mansoni lamin 0.0027 0.0073 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0012 0.0012
Trypanosoma brucei zeta tubulin 0.0421 0.2525 0.7911
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0022
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0671 0.0807
Loa Loa (eye worm) tubulin alpha-3 chain 0.0237 0.138 0.2385
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0202 0.1162 0.3639
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0043 0.0075
Brugia malayi MAP kinase sur-1 0.0202 0.1162 0.3639
Plasmodium falciparum glutathione reductase 0.0016 0.0003 0.0008
Schistosoma mansoni GTP-binding protein alpha subunit 0.0022 0.0037 0.0045
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0079 0.0094
Leishmania major beta tubulin 0.0529 0.3191 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.0201 0.0242
Echinococcus multilocularis Tubulin beta 2C chain 0.0529 0.3191 0.3835
Brugia malayi conserved hypotetical protein 0.0023 0.0043 0.0136
Leishmania major beta tubulin 0.0529 0.3191 1
Echinococcus granulosus lamin 0.0027 0.0073 0.0088
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0043 0.0052
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0235 0.1363 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0243 0.0292
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1162 0.1396
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0046 0.0145
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0012 0.0012
Echinococcus multilocularis microtubule associated protein 2 0.0701 0.4267 0.5128
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0048 0.0201 0.0631
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0017
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0139 0.0436
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0122 0.0147
Trypanosoma brucei epsilon tubulin 0.0297 0.1753 0.5492
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0157 0.088 0.5904
Echinococcus multilocularis geminin 0.1353 0.8322 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0187 0.1066 0.1281
Loa Loa (eye worm) hypothetical protein 0.0398 0.2382 0.4118
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0012 0.0012
Echinococcus multilocularis dna polymerase eta 0.0062 0.0288 0.0346
Giardia lamblia DINP protein human, muc B family 0.0037 0.0135 0.0422
Echinococcus granulosus Tubulin beta 2C chain 0.0529 0.3191 0.3835
Trichomonas vaginalis tubulin gamma chain, putative 0.0325 0.1922 0.6023
Echinococcus multilocularis carbonic anhydrase 0.0341 0.2023 0.2431
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0048 0.0201 0.0242
Mycobacterium ulcerans esterase/lipase LipP 0.0254 0.1483 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0048 0.0201 0.0242
Echinococcus granulosus tubulin alpha 1C chain 0.0398 0.2382 0.2862
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0489 0.0588
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0136 0.0751 0.5502
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.012 0.0207
Loa Loa (eye worm) hypothetical protein 0.0062 0.0288 0.0498
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0048 0.0201 0.0242
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0012 0.0063
Echinococcus multilocularis tubulin alpha 3 chain 0.0398 0.2382 0.2862
Echinococcus multilocularis survival motor neuron protein 1 0.0469 0.282 0.3388
Schistosoma mansoni RAR-like nuclear receptor 0.0048 0.0201 0.0242
Loa Loa (eye worm) hypothetical protein 0.0031 0.0095 0.0164
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0043 0.0052
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0043 0.0052
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0437 0.2621 0.8213
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.012 0.0207
Loa Loa (eye worm) MBCTL1 0.0055 0.0243 0.042
Schistosoma mansoni ferritin 0.0157 0.088 0.1058
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0046 0.0145
Loa Loa (eye worm) hypothetical protein 0.0469 0.282 0.4875
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0064
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0139 0.0167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0319 0.0999
Echinococcus granulosus Tubulin beta 2C chain 0.0529 0.3191 0.3835
Loa Loa (eye worm) tubulin beta chain 0.0136 0.0751 0.1298
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0128 0.04
Echinococcus multilocularis insulin receptor 0.0219 0.1267 0.1522
Trypanosoma brucei beta tubulin 0.0297 0.1753 0.5492
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0012 0.0063
Trypanosoma brucei unspecified product 0.0026 0.0063 0.0196
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.0386 0.0386
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0193 0.0232
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0154 0.086 0.086
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0012 0.0037
Schistosoma mansoni hypothetical protein 0.0032 0.0099 0.012
Echinococcus multilocularis Tubulin alpha 1 chain 0.0398 0.2382 0.2862
Trypanosoma brucei epsilon tubulin 0.0325 0.1922 0.6023
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0022 0.0037 0.0116
Loa Loa (eye worm) hypothetical protein 0.0082 0.0414 0.0716
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0254 0.1483 0.1483
Loa Loa (eye worm) tubulin alpha chain 0.0398 0.2382 0.4118
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0022 0.0037 0.0116
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.0386 0.1209
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0235 0.1363 0.427
Schistosoma mansoni bromodomain containing protein 0.0131 0.0718 0.0862
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0063 0.0196
Onchocerca volvulus Huntingtin homolog 0.0122 0.0662 0.2352
Leishmania major beta tubulin 0.0529 0.3191 1
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.1066 0.3341
Trichomonas vaginalis penicillin-binding protein, putative 0.0254 0.1483 0.4646
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0193 0.0232
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0191 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0048 0.0201 0.0631
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0114 0.0114
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0116 0.0139
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0341 0.2023 0.6338
Schistosoma mansoni carbonic anhydrase-related 0.0341 0.2023 0.2431
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0269 0.0844
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1776 0.5564
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.1069 0.3349
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0022 0.0037 0.0116
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0224 0.1294 0.1555
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0046 0.0145
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0081 0.0406 0.2676
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.006 0.0072
Brugia malayi Furin-like cysteine rich region family protein 0.0256 0.1493 0.4678
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0529 0.3191 0.3835
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0048 0.0201 0.0631
Loa Loa (eye worm) hypothetical protein 0.0027 0.007 0.0121
Loa Loa (eye worm) tubulin alpha 2 0.0262 0.1533 0.2651
Echinococcus granulosus tubulin delta chain 0.0136 0.0751 0.0902
Trypanosoma cruzi tubulin delta chain 0.0307 0.1812 0.5677
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.012 0.0376
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0437 0.2621 0.8213
Echinococcus granulosus peptidase Clp S14 family 0.0154 0.086 0.1033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Brugia malayi follicle stimulating hormone receptor 0.0233 0.1351 0.4233
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0122 0.0147
Echinococcus granulosus tubulin gamma 1 chain 0.0325 0.1925 0.2313
Loa Loa (eye worm) hypothetical protein 0.0086 0.0439 0.0759
Brugia malayi Protein kinase domain containing protein 0.0219 0.1267 0.397
Brugia malayi nuclear receptor NHR-88 0.0023 0.0043 0.0136
Echinococcus multilocularis musashi 0.0027 0.0073 0.0088
Trypanosoma brucei ISWI complex protein 0.0032 0.0099 0.0312
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0235 0.1363 1
Echinococcus granulosus tubulin subunit TubB 0.0398 0.2382 0.2862
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0139 0.1005
Echinococcus multilocularis Tubulin alpha 1 chain 0.0398 0.2382 0.2862
Mycobacterium ulcerans bacterioferritin BfrA 0.0157 0.088 0.593
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Mycobacterium tuberculosis Probable hydrolase 0.0254 0.1483 0.1483
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0051
Leishmania major cytochrome p450-like protein 0.0018 0.0012 0.0037
Schistosoma mansoni tyrosine kinase 0.0256 0.1493 0.1794
Echinococcus granulosus Tubulin beta 2C chain 0.0529 0.3191 0.3835
Onchocerca volvulus 0.0082 0.0414 0.1471
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0064
Echinococcus multilocularis tubulin subunit TubB 0.0398 0.2382 0.2862
Brugia malayi beta-lactamase family protein 0.0254 0.1483 0.4646
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0003 0.0008
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.005 0.0214 0.0257
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0122 0.0147
Echinococcus multilocularis tyrosine protein kinase Srms 0.0046 0.0186 0.0224
Leishmania major beta tubulin 0.0529 0.3191 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0136 0.0751 0.0751
Brugia malayi cytochrome P450 0.0018 0.0012 0.0037
Brugia malayi nuclear receptor RXR 0.0025 0.006 0.0189
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0046 0.0145
Brugia malayi Protein kinase domain containing protein 0.0092 0.0475 0.149
Schistosoma mansoni rab6-interacting 0.002 0.003 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0504 0.3039 0.9522
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0191 0.023
Schistosoma mansoni carbonic anhydrase-related 0.0341 0.2023 0.2431
Brugia malayi intermediate filament protein 0.0027 0.0073 0.0229
Trichomonas vaginalis D-aminoacylase, putative 0.0254 0.1483 0.4646
Leishmania major beta tubulin 0.0529 0.3191 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0135 0.0422
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0202 0.0242
Loa Loa (eye worm) hypothetical protein 0.0254 0.1483 0.2564
Loa Loa (eye worm) hypothetical protein 0.0235 0.1363 0.2356
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0254 0.1483 0.2564
Brugia malayi hypothetical protein 0.0023 0.0043 0.0136
Loa Loa (eye worm) hypothetical protein 0.0945 0.5784 1
Toxoplasma gondii ABC1 family protein 0.0254 0.1483 0.4646
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0043 0.0154
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0043 0.0052
Onchocerca volvulus 0.0254 0.1483 0.527
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0048 0.0201 0.0242
Echinococcus multilocularis tubulin alpha 3 chain 0.0398 0.2382 0.2862
Echinococcus multilocularis tubulin alpha 1C chain 0.0398 0.2382 0.2862
Mycobacterium ulcerans bacterioferritin BfrB 0.0157 0.088 0.593
Trypanosoma brucei unspecified product 0.0037 0.0135 0.0422
Loa Loa (eye worm) hypothetical protein 0.0146 0.0813 0.1406
Echinococcus granulosus twitchin 0.0017 0.0005 0.0006
Echinococcus multilocularis tubulin alpha chain 0.0398 0.2382 0.2862
Trichomonas vaginalis tubulin beta chain, putative 0.0529 0.3191 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.006 0.0072
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0202 0.0348
Brugia malayi Pre-SET motif family protein 0.0059 0.0269 0.0844
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.1776 0.5564
Trichomonas vaginalis tubulin, putative 0.0529 0.3191 1
Brugia malayi SRC-1 0.005 0.0214 0.067
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0012 0.0012
Schistosoma mansoni loxhd1 0.002 0.003 0.0036
Brugia malayi hypothetical protein 0.0148 0.0822 0.2574
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0022
Echinococcus multilocularis muscleblind protein 0.0151 0.0839 0.1008
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0202 0.1162 0.3639
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0048 0.0201 0.0242
Echinococcus multilocularis beta tubulin 0.0529 0.3191 0.3835
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1776 0.5564
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0022 0.0037 0.0045
Brugia malayi hypothetical protein 0.0023 0.0043 0.0136
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.005 0.0214 0.0257
Trichomonas vaginalis tubulin beta chain, putative 0.0398 0.2382 0.7462
Echinococcus granulosus geminin 0.1353 0.8322 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0008
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0191 0.0599
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0043 0.0136
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0012 0.0063
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0012 0.0012
Brugia malayi Cell division protein ftsZ 0.0136 0.0751 0.2353
Giardia lamblia PHD finger protein 15 0.0028 0.0079 0.0246
Loa Loa (eye worm) cytochrome P450 0.0018 0.0012 0.0021
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0022 0.0037 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1776 0.5564
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0064
Echinococcus multilocularis beta tubulin 0.0529 0.3191 0.3835
Trichomonas vaginalis tubulin beta chain, putative 0.0161 0.0904 0.2834
Trypanosoma brucei trypanothione reductase 0.0046 0.0191 0.0599
Echinococcus granulosus tubulin alpha 3 chain 0.0398 0.2382 0.2862
Schistosoma mansoni rab6-interacting 0.002 0.003 0.0036
Leishmania major beta tubulin 0.0529 0.3191 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0161 0.0904 0.2834
Echinococcus multilocularis Tubulin alpha 1 chain 0.0398 0.2382 0.2862
Trichomonas vaginalis tubulin beta chain, putative 0.0398 0.2382 0.7462
Echinococcus multilocularis tubulin epsilon chain 0.0325 0.1922 0.231
Schistosoma mansoni nuclear receptor 0.0023 0.0043 0.0052
Loa Loa (eye worm) TK/EGFR protein kinase 0.0256 0.1493 0.2581
Schistosoma mansoni ferritin light chain 0.0157 0.088 0.1058
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.1066 0.3341
Echinococcus multilocularis carbonic anhydrase 0.0341 0.2023 0.2431
Echinococcus granulosus Tubulin alpha 1 chain 0.0398 0.2382 0.2862
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0266 0.046
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0043 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0043 0.0052
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0139 0.0167
Echinococcus granulosus tyrosine kinase 0.0046 0.0186 0.0224
Trichomonas vaginalis set domain proteins, putative 0.0468 0.2814 0.8817
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.001 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0048 0.0201 0.0631
Schistosoma mansoni polycystin 1-related 0.002 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0094 0.0489 0.0845
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.005 0.0214 0.0257
Brugia malayi G-protein alpha subunit 0.0022 0.0037 0.0116
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0012 0.0012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0254 0.1483 1
Trichomonas vaginalis ferritin, putative 0.0157 0.088 0.2758
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0012 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0202 0.1162 0.3639
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0214 0.0257
Echinococcus granulosus Tubulin alpha 1 chain 0.0398 0.2382 0.2862
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0201 0.0242
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0235 0.1363 0.9188
Loa Loa (eye worm) tubulin alpha 2 0.0262 0.1533 0.2651
Brugia malayi Tubulin alpha chain 0.0398 0.2382 0.7462
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0224 0.1294 0.1555
Loa Loa (eye worm) hypothetical protein 0.0088 0.0452 0.0781
Toxoplasma gondii hypothetical protein 0.0081 0.0406 0.1271
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0064
Onchocerca volvulus 0.0468 0.2814 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0201 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0046 0.0297
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0048 0.0201 0.0242
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Schistosoma mansoni tyrosine kinase 0.005 0.0214 0.0257
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0136
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0022 0.0037 0.0116
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0003 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0012 0.0012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.0822 0.0987
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0012 0.0063
Brugia malayi mbt repeat family protein 0.0048 0.0202 0.0632
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0012 0.0063
Onchocerca volvulus 0.0082 0.0414 0.1471
Loa Loa (eye worm) hypothetical protein 0.0049 0.0205 0.0354
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0148 0.0177
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0135 0.0422
Echinococcus multilocularis RUN 0.002 0.003 0.0036
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.015 0.018
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.003 0.0036
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0561 0.0561
Brugia malayi jmjC domain containing protein 0.0093 0.048 0.1503
Echinococcus granulosus expressed protein 0.0022 0.0037 0.0045
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0022 0.0037 0.0045
Schistosoma mansoni thyroid hormone receptor 0.0177 0.1002 0.1204
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0135 0.0422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0048 0.0201 0.0348
Echinococcus granulosus tubulin subunit beta 0.0529 0.3191 0.3835
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0254 0.1483 0.1782
Brugia malayi Muscleblind-like protein 0.0151 0.0839 0.263
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Echinococcus granulosus Tubulin alpha 1 chain 0.0398 0.2382 0.2862
Loa Loa (eye worm) tubulin gamma chain 0.0325 0.1925 0.3328
Brugia malayi tailless protein 0.0023 0.0043 0.0136
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.003 0.0036
Echinococcus granulosus tubulin beta 1 chain 0.0529 0.3191 0.3835
Trypanosoma brucei polo-like protein kinase 0.0187 0.1066 0.3341
Loa Loa (eye worm) hypothetical protein 0.0151 0.0839 0.1451
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0017
Trypanosoma brucei alpha tubulin 0.0398 0.2382 0.7462
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Leishmania major beta tubulin 0.0529 0.3191 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0022 0.0037 0.0045
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0012 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0012 0.0012
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0012 0.0063
Brugia malayi jmjC domain containing protein 0.0038 0.014 0.044
Schistosoma mansoni survival motor neuron protein 0.0096 0.0497 0.0598
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0046 0.0046
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0022 0.0037 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0048 0.0201 0.0348
Loa Loa (eye worm) hypothetical protein 0.0254 0.1483 0.2564
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0048 0.0201 0.0348
Echinococcus granulosus expressed protein 0.0157 0.088 0.1058
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0504 0.3039 0.3652
Loa Loa (eye worm) BEN-1 protein 0.0529 0.3191 0.5518
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0406 0.1271
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0484 0.1518
Entamoeba histolytica tubulin gamma chain 0.0325 0.1925 0.603
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0043 0.0154
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0386 0.1209
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Brugia malayi Cation transporter family protein 0.0082 0.0414 0.1297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0008
Brugia malayi nuclear receptor NHR-67 0.0023 0.0043 0.0136
Trypanosoma cruzi tubulin delta chain 0.0307 0.1812 0.5677
Brugia malayi hypothetical protein 0.0469 0.282 0.8835
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.113 0.354
Schistosoma mansoni tubulin subunit beta 0.0529 0.3191 0.3835
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.246 0.4254
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0046 0.0145
Trichomonas vaginalis esterase, putative 0.0254 0.1483 0.4646
Echinococcus multilocularis Tubulin beta 2C chain 0.0529 0.3191 0.3835
Echinococcus granulosus tar DNA binding protein 0.0197 0.113 0.1358
Echinococcus multilocularis mitogen activated protein kinase 0.0202 0.1162 0.1396
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0254 0.1483 0.1782
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0008
Echinococcus multilocularis peregrin 0.0033 0.0109 0.0131
Brugia malayi Tubulin beta chain 0.0136 0.0751 0.2353
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0046 0.0046
Brugia malayi serine/threonine-protein kinase plk-2 0.0187 0.1066 0.3341
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.2721 0.3269
Onchocerca volvulus 0.0082 0.0414 0.1471
Trichomonas vaginalis tubulin, putative 0.0161 0.0904 0.2834
Loa Loa (eye worm) hypothetical protein 0.0048 0.0201 0.0348
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.003 0.0036
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0073 0.0126
Echinococcus granulosus Tubulin beta 2C chain 0.0529 0.3191 0.3835
Schistosoma mansoni tubulin subunit alpha 0.0398 0.2382 0.2862
Trypanosoma brucei unspecified product 0.0026 0.0063 0.0196
Schistosoma mansoni tar DNA-binding protein 0.0197 0.113 0.1358
Leishmania major beta tubulin 0.0529 0.3191 1
Trichomonas vaginalis tubulin beta chain, putative 0.0398 0.2382 0.7462
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0022 0.0037 0.0116
Brugia malayi hypothetical protein 0.0025 0.006 0.0189
Brugia malayi nuclear receptor NHR-88 0.0048 0.0201 0.0631
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0048 0.0201 0.0348
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0671 0.0807
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0561 0.0561
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0157 0.088 0.088
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.001 0.0055
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0104
Schistosoma mansoni ap endonuclease 0.0078 0.0386 0.0464
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0048 0.0201 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0269 0.0324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0504 0.3039 0.3652
Giardia lamblia Beta tubulin 0.0529 0.3191 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0254 0.1483 0.4646
Echinococcus multilocularis GPCR, family 2 0.0031 0.0095 0.0114
Trypanosoma cruzi tubulin gamma chain 0.0325 0.1925 0.603
Schistosoma mansoni hypothetical protein 0.0308 0.1818 0.2185
Brugia malayi nuclear hormone receptor 0.0048 0.0201 0.0631
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.1066 0.3341
Echinococcus granulosus carbonic anhydrase II 0.0437 0.2621 0.315
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.0288 0.0902
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0235 0.1363 0.427
Echinococcus granulosus carbonic anhydrase 0.0341 0.2023 0.2431
Leishmania major beta tubulin 0.0529 0.3191 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0191 0.023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0048 0.0201 0.0631
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0437 0.2621 0.8213
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0635 0.0635
Trypanosoma brucei tubulin delta chain 0.0307 0.1812 0.5677
Treponema pallidum cell division protein FtsZ 0.0136 0.0751 0.4228
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0202 0.1162 0.3639
Onchocerca volvulus 0.0023 0.0043 0.0154
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0386 0.1209
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0437 0.2621 0.8213
Echinococcus granulosus microtubule associated protein 2 0.0701 0.4267 0.5128
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0703 0.0845
Brugia malayi beta-tubulin, identical 0.0529 0.3191 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0202 0.1162 0.3639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0048 0.0201 0.0348
Loa Loa (eye worm) steroid hormone receptor 0.0048 0.0201 0.0348
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.005 0.0214 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.1066 0.3341
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Mycobacterium tuberculosis Conserved protein 0.0254 0.1483 0.1483
Plasmodium vivax delta tubulin, putative 0.0136 0.0751 0.2353
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0386 0.1209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0048 0.0201 0.0348
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0243 0.0292
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0202 0.0716
Leishmania major cytochrome p450-like protein 0.0035 0.012 0.0376
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0512 0.1603
Brugia malayi Tubulin alpha chain 0.0136 0.0751 0.2353
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0235 0.1363 1
Schistosoma mansoni tyrosine kinase 0.0172 0.0974 0.1171
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0048 0.0201 0.0631
Loa Loa (eye worm) TK protein kinase 0.0046 0.0186 0.0322
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Trichomonas vaginalis tubulin epsilon chain, putative 0.0398 0.2382 0.7462
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0154 0.086 0.5763
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0187 0.1066 0.3341
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.015 0.018
Echinococcus granulosus Tubulin beta 2C chain 0.0529 0.3191 0.3835
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0063 0.0196
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0012 0.0063
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.0822 0.0987
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0235 0.1363 0.427
Echinococcus multilocularis thyroid hormone receptor alpha 0.0177 0.1002 0.1204
Onchocerca volvulus 0.0254 0.1483 0.527
Trichomonas vaginalis tubulin, putative 0.0164 0.0923 0.2891
Brugia malayi tubulin alpha chain - mouse 0.0398 0.2382 0.7462
Schistosoma mansoni tar DNA-binding protein 0.0197 0.113 0.1358
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0048 0.0201 0.0242
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0139 0.0436
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0003 0.0008
Trichomonas vaginalis tubulin alpha chain, putative 0.0161 0.0904 0.2834
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0043 0.0075
Schistosoma mansoni tubulin subunit beta 0.0529 0.3191 0.3835
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0135 0.0894
Echinococcus multilocularis tyrosine protein kinase Fgr 0.005 0.0214 0.0257
Mycobacterium leprae Probable lipase LipE 0.0254 0.1483 1
Trypanosoma cruzi zeta tubulin, putative 0.0421 0.2525 0.7911
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.003 0.0036
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.0818 0.0818
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0064
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0012 0.0063
Schistosoma mansoni lipoxygenase 0.0122 0.0664 0.0798
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0073 0.0126
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.0386 0.0464
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0022 0.0037 0.0045
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0048 0.0201 0.0242
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0341 0.2023 0.6338
Loa Loa (eye worm) RNA binding protein 0.0197 0.113 0.1954
Toxoplasma gondii alpha tubulin TUBA1 0.0398 0.2382 0.7462
Mycobacterium leprae cell division protein FtsZ 0.0136 0.0751 0.5023
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0135 0.0162
Brugia malayi Tubulin gamma chain 0.0325 0.1925 0.603
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0082 0.0414 0.0497
Trichomonas vaginalis tubulin gamma chain, putative 0.0136 0.0751 0.2353
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0122 0.0662 0.1144
Echinococcus multilocularis expressed protein 0.0157 0.088 0.1058
Brugia malayi hypothetical protein 0.0022 0.0037 0.0116
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0154 0.086 0.086
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0243 0.0292
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0022 0.0037 0.0045
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0254 0.1483 0.1483
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0172 0.0974 0.1171
Schistosoma mansoni hypothetical protein 0.0341 0.2023 0.2431
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0561 0.0561
Mycobacterium leprae conserved hypothetical protein 0.0254 0.1483 1
Schistosoma mansoni tubulin subunit beta 0.0529 0.3191 0.3835
Brugia malayi Cytochrome P450 family protein 0.0018 0.0012 0.0037
Plasmodium vivax glutathione reductase, putative 0.0046 0.0191 0.0599
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.0818 0.5506
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0079 0.0246
Brugia malayi nuclear receptor RXR 0.0023 0.0043 0.0136
Brugia malayi Inositol-1 0.0038 0.0139 0.0436
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0202 0.1162 0.3639
Echinococcus multilocularis tubulin alpha 1C chain 0.0398 0.2382 0.2862
Trichomonas vaginalis tubulin, putative 0.0161 0.0904 0.2834
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0022 0.0037 0.0045
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.006 0.0072
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0022 0.0037 0.0116
Trypanosoma brucei alpha tubulin, putative 0.0161 0.0904 0.2834
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0046 0.0145
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0012 0.0037
Echinococcus granulosus peroxisome assembly protein 26 0.0398 0.2382 0.2862
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0003 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0003 0.0008
Schistosoma mansoni ferritin 0.0157 0.088 0.1058
Entamoeba histolytica tubulin family protein 0.0529 0.3191 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0139 0.0436
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.014 0.0169
Trichomonas vaginalis tubulin gamma chain, putative 0.0529 0.3191 1
Giardia lamblia Gamma tubulin 0.0325 0.1925 0.603
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0046 0.0297
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0157 0.088 0.088
Schistosoma mansoni kinase 0.0096 0.05 0.06
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0202 0.1162 0.3639
Schistosoma mansoni tyrosine kinase 0.0172 0.0974 0.1171
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0012 0.0012
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.013 0.0225
Brugia malayi glutathione reductase 0.0046 0.0191 0.0599
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0046 0.0297
Loa Loa (eye worm) hypothetical protein 0.0151 0.0839 0.1451
Trichomonas vaginalis tubulin epsilon chain, putative 0.0529 0.3191 1
Loa Loa (eye worm) tubulin alpha 2 0.0101 0.0531 0.0918
Echinococcus multilocularis 0.0018 0.0012 0.0014
Schistosoma mansoni tubulin subunit gamma 0.0325 0.1925 0.2313
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Brugia malayi steroid hormone receptor 0.0048 0.0201 0.0631
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0139 0.0436
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0437 0.2621 0.315
Plasmodium falciparum thioredoxin reductase 0.0046 0.0191 0.0599
Echinococcus granulosus beta LACTamase domain containing family member 0.0254 0.1483 0.1782
Leishmania major trypanothione reductase 0.0046 0.0191 0.0599
Trypanosoma brucei beta tubulin 0.0529 0.3191 1
Mycobacterium tuberculosis Probable reductase 0.0106 0.0561 0.0561
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0122 0.0147
Schistosoma mansoni hypothetical protein 0.0031 0.0095 0.0114
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0079 0.0246
Brugia malayi mbt repeat family protein 0.0048 0.0202 0.0632
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0157 0.088 0.6453
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0082 0.0414 0.0497
Onchocerca volvulus 0.0022 0.0037 0.0132
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0008
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0003
Schistosoma mansoni nephrin 0.0018 0.0017 0.0021
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0043 0.0136
Toxoplasma gondii beta-1 tubulin, putative 0.0529 0.3191 1
Leishmania major cytochrome p450-like protein 0.0018 0.0012 0.0037
Schistosoma mansoni carbonic anhydrase 0.0341 0.2023 0.2431
Trichomonas vaginalis tubulin epsilon chain, putative 0.0398 0.2382 0.7462
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0043 0.0052
Trypanosoma cruzi ISWI complex protein 0.0032 0.0099 0.0312
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0022 0.0037 0.0045
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0043 0.0052
Schistosoma mansoni hypothetical protein 0.0031 0.0095 0.0114
Echinococcus granulosus RUN 0.002 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0082 0.0414 0.0716
Schistosoma mansoni carbonic anhydrase-related 0.0341 0.2023 0.2431
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0297 0.1753 0.5492
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.012 0.0376
Trichomonas vaginalis tubulin beta chain, putative 0.0398 0.2382 0.7462
Plasmodium vivax tubulin alpha chain, putative 0.0398 0.2382 0.7462
Loa Loa (eye worm) CYP4Cod1 0.0035 0.012 0.0207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0504 0.3039 0.3652
Echinococcus granulosus intermediate filament protein 0.0027 0.0073 0.0088
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0703 0.0845
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Onchocerca volvulus 0.0048 0.0202 0.0716
Giardia lamblia Delta tubulin 0.0136 0.0751 0.2353
Trypanosoma brucei carbonic anhydrase-like protein 0.0437 0.2621 0.8213
Echinococcus multilocularis tubulin beta 1 chain 0.0529 0.3191 0.3835
Trichomonas vaginalis CMGC family protein kinase 0.0202 0.1162 0.3639
Schistosoma mansoni ferritin 0.0157 0.088 0.1058
Leishmania major zeta tubulin, putative 0.0421 0.2525 0.7911
Schistosoma mansoni tyrosine kinase 0.0219 0.1267 0.1522
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0012 0.0063
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0079 0.0246
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0243 0.0761
Echinococcus granulosus tubulin beta 4A class IVa 0.0529 0.3191 0.3835
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0012 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0504 0.3039 0.3652
Echinococcus granulosus tubulin alpha chain 0.0398 0.2382 0.2862
Echinococcus granulosus tubulin alpha chain 0.0398 0.2382 0.2862
Onchocerca volvulus 0.0027 0.0073 0.0259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0504 0.3039 0.3652
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Onchocerca volvulus Serine\/threonine kinase homolog 0.0187 0.1066 0.379
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0022 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0122 0.0662 0.1144
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0202 0.0242
Loa Loa (eye worm) tubulin beta-1 chain 0.0529 0.3191 0.5518
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0406 0.1271
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0003 0.0008
Plasmodium falciparum phd finger protein, putative 0.0028 0.0079 0.0246
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0497 0.1559
Echinococcus multilocularis tyrosine protein kinase Src64B 0.005 0.0214 0.0257
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.0386 0.0464
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0048 0.0201 0.0631
Loa Loa (eye worm) hypothetical protein 0.0254 0.1483 0.2564
Echinococcus multilocularis peptidase Clp (S14 family) 0.0154 0.086 0.1033
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0022 0.0037 0.0064
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0202 0.1162 0.2008
Plasmodium falciparum tubulin delta chain, putative 0.0136 0.0751 0.2353
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0104
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0664 0.0798
Trichomonas vaginalis tubulin beta chain, putative 0.0398 0.2382 0.7462
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0022 0.0037 0.0116
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0202 0.0242
Treponema pallidum exodeoxyribonuclease (exoA) 0.0078 0.0386 0.2173
Trichomonas vaginalis tubulin epsilon chain, putative 0.0136 0.0751 0.2353
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0148 0.0177
Onchocerca volvulus 0.002 0.003 0.0106
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0361 0.0434
Schistosoma mansoni alpha tubulin 0.0398 0.2382 0.2862
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.0822 0.0987
Onchocerca volvulus 0.0161 0.0904 0.3214
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0235 0.1363 0.7674
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0504 0.3039 0.3652
Loa Loa (eye worm) TK/INSR protein kinase 0.0219 0.1267 0.219
Onchocerca volvulus 0.0048 0.0201 0.0715
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0046 0.0297
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Loa Loa (eye worm) SRC-1 0.005 0.0214 0.037
Echinococcus multilocularis hypothetical protein 0.0398 0.2382 0.2862
Echinococcus multilocularis tubulin subunit beta 0.0529 0.3191 0.3835
Plasmodium falciparum alpha tubulin 2 0.0398 0.2382 0.7462
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.0386 0.2818
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0256 0.0307
Schistosoma mansoni thyroid hormone receptor 0.0177 0.1002 0.1204
Schistosoma mansoni ferritin 0.0157 0.088 0.1058
Echinococcus granulosus carbonic anhydrase 0.0341 0.2023 0.2431
Mycobacterium ulcerans hypothetical protein 0.0254 0.1483 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0048 0.0201 0.0242
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Echinococcus multilocularis tubulin delta chain 0.0136 0.0751 0.0902
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0193 0.0232
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0022 0.0037 0.0116
Plasmodium vivax tubulin beta chain, putative 0.0529 0.3191 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0073 0.0088
Leishmania major epsilon tubulin, putative 0.0325 0.1922 0.6023
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0048 0.0201 0.0631
Schistosoma mansoni inositol monophosphatase 0.0038 0.0139 0.0167
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.006 0.0189
Echinococcus granulosus lamin dm0 0.0027 0.0073 0.0088
Echinococcus granulosus beta tubulin 0.0529 0.3191 0.3835
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0022 0.0037 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0386 0.1209
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Echinococcus multilocularis FTZ F1 alpha 0.0048 0.0201 0.0242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0048 0.0201 0.0631
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0095 0.0114
Leishmania major alpha tubulin 0.0398 0.2382 0.7462
Mycobacterium ulcerans lipase LipD 0.0254 0.1483 1
Onchocerca volvulus 0.0022 0.0037 0.0132
Brugia malayi hypothetical protein 0.002 0.003 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0012 0.0012
Echinococcus multilocularis carbonic anhydrase 0.0341 0.2023 0.2431
Plasmodium falciparum tubulin epsilon chain, putative 0.0325 0.1922 0.6023
Trichomonas vaginalis tubulin epsilon chain, putative 0.0529 0.3191 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1776 0.5564
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0104
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.0135 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1776 0.5564
Plasmodium falciparum alpha tubulin 1 0.0398 0.2382 0.7462
Entamoeba histolytica serine/threonine protein kinase, putative 0.0187 0.1066 0.3341
Echinococcus multilocularis tyrosine protein kinase Blk 0.0046 0.0186 0.0224
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0341 0.2023 0.6338
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0095 0.0298
Mycobacterium tuberculosis Probable lipase LipD 0.0254 0.1483 0.1483
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0135 0.0422
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.0386 0.1209
Echinococcus multilocularis muscleblind protein 1 0.0151 0.0839 0.1008
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.014 0.0243
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0012 0.0012
Echinococcus granulosus mitogen activated protein kinase 0.0202 0.1162 0.1396
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.0386 0.1209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0489 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0048 0.0201 0.0631
Schistosoma mansoni tubulin subunit beta 0.0529 0.3191 0.3835
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0075
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0202 0.0242
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0079 0.0094
Toxoplasma gondii tubulin, putative 0.0027 0.0072 0.0225
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0341 0.2023 0.3497
Echinococcus multilocularis epidermal growth factor receptor 0.0172 0.0974 0.1171
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0073 0.0229
Loa Loa (eye worm) hypothetical protein 0.0027 0.0073 0.0126
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0243 0.0292
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0135 0.0135

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4 nM Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control ChEMBL. 18308565
IC50 (binding) = 4 nM Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control ChEMBL. 18308565
IC50 (binding) = 11 nM Inhibition of human recombinant VEGFR2 by HTRF assay ChEMBL. 18308565
IC50 (binding) = 11 nM Inhibition of human recombinant VEGFR2 by HTRF assay ChEMBL. 18308565
IC50 (binding) = 66 nM Inhibition of human recombinant TIE2 by HTRF assay ChEMBL. 18308565
IC50 (binding) = 66 nM Inhibition of human recombinant TIE2 by HTRF assay ChEMBL. 18308565

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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