Detailed information for compound 509513

Basic information

Technical information
  • TDR Targets ID: 509513
  • Name: 3-[1-(4-methylphenyl)cyclopentyl]-5,6,7,8,9,1 0-hexahydro-[1,2,4]triazolo[4,3-a]azocine
  • MW: 309.448 | Formula: C20H27N3
  • H donors: 0 H acceptors: 2 LogP: 4.74 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C1(CCCC1)c1nnc2n1CCCCCC2
  • InChi: 1S/C20H27N3/c1-16-9-11-17(12-10-16)20(13-5-6-14-20)19-22-21-18-8-4-2-3-7-15-23(18)19/h9-12H,2-8,13-15H2,1H3
  • InChiKey: QCBITCMHMMZFGC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[1-(p-tolyl)cyclopentyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine
  • 3-[1-(4-methylphenyl)cyclopentyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,5-a]azocine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 2 Starlite/ChEMBL References
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 Starlite/ChEMBL References
Mus musculus hydroxysteroid 11-beta dehydrogenase 1 Starlite/ChEMBL References
Mus musculus hydroxysteroid 11-beta dehydrogenase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans short chain dehydrogenase Get druggable targets OG5_132866 All targets in OG5_132866
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_132866 All targets in OG5_132866
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid 11-beta dehydrogenase 1 292 aa 246 aa 25.2 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid (11-beta) dehydrogenase 1 292 aa 250 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0965 0.0963
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0335 0.0333
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0322 0.0336
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0651 0.065
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0118 0.136 0.2142
Schistosoma mansoni peptidylglycine monooxygenase 0.0274 0.3448 0.3446
Echinococcus multilocularis hypothetical protein 0.0021 0.0075 0.0073
Echinococcus multilocularis tubulin alpha chain 0.0021 0.0075 0.0073
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0118 0.136 0.1359
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.072 0.0783
Plasmodium vivax tubulin alpha chain, putative 0.0021 0.0075 0.0784
Onchocerca volvulus Alhambra homolog 0.0031 0.0201 0.03
Brugia malayi Pre-SET motif family protein 0.0065 0.0653 0.1027
Echinococcus granulosus Tubulin beta 2C chain 0.0055 0.0523 0.0522
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0019 0.0038 0.0017
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0965 0.1518
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0019 0.0038 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0436 0.0434
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0135 0.1591 0.2506
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0038 0.0017
Loa Loa (eye worm) beta-tubulin 0.0055 0.0523 0.0822
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0322 0.032
Onchocerca volvulus 0.0491 0.6343 0.9545
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.0038 0.009
Brugia malayi hypoxia-induced factor 1 0.0327 0.4146 0.6535
Onchocerca volvulus Huntingtin homolog 0.013 0.1521 0.2287
Schistosoma mansoni bromodomain containing protein 0.0137 0.162 0.1619
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0436 0.0434
Echinococcus granulosus tubulin alpha 3 chain 0.0021 0.0075 0.0073
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0335 0.0525
Onchocerca volvulus 0.0019 0.0038 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0102 0.1146 0.1145
Echinococcus granulosus tubulin gamma 1 chain 0.0021 0.0075 0.0073
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0386 0.0606
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0081 0.012
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0019 0.0038 0.0167
Leishmania major short chain dehydrogenase, putative 0.0019 0.0038 0.009
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0085 0.0923 0.475
Mycobacterium tuberculosis Possible oxidoreductase 0.0019 0.0038 0.0017
Leishmania major hypothetical protein, conserved 0.0023 0.0091 0.0408
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0081 0.008
Trichomonas vaginalis tubulin epsilon chain, putative 0.0055 0.0523 0.0735
Schistosoma mansoni coup transcription factor 0.0022 0.0081 0.008
Echinococcus granulosus SAM and MBT domain containing protein 0.0103 0.1169 0.1168
Echinococcus multilocularis Tubulin alpha 1 chain 0.0021 0.0075 0.0073
Onchocerca volvulus Huntingtin homolog 0.013 0.1521 0.2287
Loa Loa (eye worm) RNA binding protein 0.0067 0.0685 0.1077
Trichomonas vaginalis tubulin beta chain, putative 0.0021 0.0075 0.0056
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0038 0.0036
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.072 0.0718
Echinococcus multilocularis Tubulin alpha 1 chain 0.0021 0.0075 0.0073
Schistosoma mansoni loxhd1 0.0065 0.0651 0.065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0081 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0653 0.0651
Onchocerca volvulus 0.0019 0.0038 0.0054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0436 0.0684
Trypanosoma brucei tubulin gamma chain 0.0021 0.0075 0.0309
Brugia malayi Tubulin beta-1 chain 0.0055 0.0523 0.0822
Brugia malayi Uncoordinated protein 44 0.0016 0.0002 0.000000076508
Brugia malayi beta-tubulin, identical 0.0055 0.0523 0.0822
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0019 0.0038 0.0036
Onchocerca volvulus 0.0019 0.0038 0.0054
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0023 0.0247
Loa Loa (eye worm) alpha-tubulin 0.0021 0.0075 0.0115
Echinococcus granulosus prolyl 4 hydroxylase subunit alpha 1 0.0023 0.0091 0.0089
Schistosoma mansoni pyruvate kinase 0.0019 0.0042 0.0041
Onchocerca volvulus 0.0019 0.0038 0.0054
Plasmodium falciparum steroid dehydrogenase, putative 0.0019 0.0038 0.0167
Schistosoma mansoni alpha tubulin 0.0021 0.0075 0.0073
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.012 0.1296
Brugia malayi hypothetical protein 0.0019 0.0038 0.0057
Leishmania major oxidoreductase-like protein 0.0019 0.0038 0.009
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.0879 0.0877
Leishmania major gamma-tubulin 0.0021 0.0075 0.0309
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0019 0.0038 0.0036
Brugia malayi Pre-SET motif family protein 0.0451 0.5811 0.9161
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0155 0.0153
Leishmania major short chain dehydrogenase, putative 0.0019 0.0038 0.009
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0081 0.008
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.03 0.0471
Schistosoma mansoni lamin 0.003 0.0188 0.0186
Leishmania major epsilon tubulin, putative 0.0021 0.0075 0.0309
Trypanosoma cruzi beta tubulin, putative 0.0055 0.0523 0.2985
Echinococcus multilocularis tubulin alpha 3 chain 0.0021 0.0075 0.0073
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0283 0.0443
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.012 0.0578
Brugia malayi jmjC domain containing protein 0.0027 0.0154 0.024
Echinococcus granulosus tubulin alpha 1C chain 0.0021 0.0075 0.0073
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0019 0.0038 0.0036
Schistosoma mansoni hypothetical protein 0.0629 0.818 0.8179
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.013 0.1517 0.1515
Brugia malayi intermediate filament protein 0.003 0.0188 0.0294
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Giardia lamblia Beta tubulin 0.0055 0.0523 0.1191
Echinococcus granulosus zinc finger protein 0.0042 0.0355 0.0354
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0207
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.072 0.0767
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0019 0.0038 0.0017
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.012 0.0092
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0019 0.0038 0.0036
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0685 0.1077
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0133 0.0207
Schistosoma mansoni pyruvate kinase 0.0037 0.0283 0.0281
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.0038 0.009
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0322 0.0336
Brugia malayi Tubulin alpha-2 chain 0.0021 0.0075 0.0115
Brugia malayi Bromodomain containing protein 0.0036 0.027 0.0423
Loa Loa (eye worm) RecQ helicase 0.0024 0.0105 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0685 0.0683
Echinococcus multilocularis lamin 0.003 0.0188 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0081 0.0126
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0038 0.0036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0166 0.2009 0.2008
Mycobacterium ulcerans putative regulatory protein 0.0078 0.0831 0.0892
Schistosoma mansoni jumonji domain containing protein 0.0146 0.1732 0.173
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0315
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.4114 0.617
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0155 0.0177
Trichomonas vaginalis tubulin gamma chain, putative 0.0021 0.0075 0.0056
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0038 0.0036
Brugia malayi hypothetical protein 0.0019 0.0038 0.0057
Trypanosoma cruzi ISWI complex protein 0.0033 0.0232 0.1246
Brugia malayi Tubulin alpha-2 chain 0.0021 0.0075 0.0115
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0158 0.1902 0.2109
Mycobacterium ulcerans lipase LipD 0.004 0.0322 0.0319
Loa Loa (eye worm) hypothetical protein 0.0102 0.1146 0.1805
Leishmania major hypothetical protein, conserved 0.004 0.0322 0.1783
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0019 0.0038 0.0017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0201 0.2159
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0087 0.0072
Onchocerca volvulus 0.0019 0.0038 0.0054
Giardia lamblia Gamma tubulin 0.0021 0.0075 0.009
Toxoplasma gondii endonuclease IV APN 0.0085 0.0923 1
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0038 0.009
Schistosoma mansoni dopamine-beta-monooxygenase 0.0519 0.6716 0.6715
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0081 0.0126
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0021
Echinococcus multilocularis lamin dm0 0.003 0.0188 0.0186
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Mycobacterium ulcerans short chain dehydrogenase 0.0685 0.8931 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0019 0.0038 0.0057
Mycobacterium tuberculosis Probable dehydrogenase 0.0019 0.0038 0.0017
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0155 0.0153
Echinococcus granulosus WW domain containing oxidoreductase 0.0019 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0322 0.043
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0188 0.0294
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.012 0.1272
Schistosoma mansoni hypothetical protein 0.0045 0.0386 0.0384
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0081 0.008
Toxoplasma gondii carbonyl reductase 1, putative 0.0019 0.0038 0.041
Giardia lamblia Pyruvate kinase 0.0019 0.0042 0.0011
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0019 0.0038 0.009
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0283 0.0443
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0322 0.0505
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0155 0.0438
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0158 0.1902 1
Onchocerca volvulus 0.0051 0.0471 0.0706
Brugia malayi mbt repeat family protein 0.0103 0.1169 0.1841
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0143 0.1699 0.2677
Echinococcus multilocularis musashi 0.003 0.0188 0.0186
Loa Loa (eye worm) oxidoreductase 0.0019 0.0038 0.0057
Echinococcus multilocularis polycomb protein SCMH1 0.0103 0.1169 0.1168
Loa Loa (eye worm) hypothetical protein 0.0354 0.4512 0.7112
Brugia malayi PHD-finger family protein 0.0054 0.051 0.0801
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0081 0.008
Toxoplasma gondii alpha tubulin TUBA1 0.0021 0.0075 0.0809
Treponema pallidum fructose-bisphosphate aldolase 0.0324 0.4114 1
Brugia malayi Doublecortin family protein 0.0065 0.0651 0.1024
Trichomonas vaginalis tubulin beta chain, putative 0.0021 0.0075 0.0056
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0143 0.1699 0.2677
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.0038 0.009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0324 0.4114 1
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0038 0.0036
Brugia malayi DOMON domain containing protein 0.0053 0.0489 0.0769
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0081 0.008
Echinococcus multilocularis tubulin beta 1 chain 0.0055 0.0523 0.0522
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Echinococcus granulosus bloom syndrome protein 0.0024 0.0105 0.0103
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0087 0.0129
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.072 0.7798
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0081 0.008
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0282 0.0281
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0155 0.0241
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0019 0.0038 0.0057
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0038 0.009
Trypanosoma brucei beta tubulin 0.0021 0.0075 0.0309
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0133 0.0234
Trypanosoma brucei beta tubulin 0.0055 0.0523 0.2985
Loa Loa (eye worm) hypothetical protein 0.0027 0.0154 0.024
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0019 0.0038 0.0017
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0023 0.0091 0.0408
Schistosoma mansoni carbonyl reductase 0.0019 0.0038 0.0036
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0408 0.5228 0.5227
Echinococcus granulosus alpha tubulin 0.0021 0.0075 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0322 0.1783
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0155 0.0177
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0653 0.0651
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0829 0.0827
Trichomonas vaginalis tubulin epsilon chain, putative 0.0021 0.0075 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0081 0.0126
Leishmania major dehydrogenase-like protein 0.0019 0.0038 0.009
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0154 0.0784
Leishmania major protein kinase, putative 0.0033 0.0227 0.1218
Loa Loa (eye worm) MBCTL1 0.0118 0.136 0.2142
Leishmania major pyruvate kinase 0.0037 0.0283 0.155
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0685 0.1077
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0002 0.000000048524
Trypanosoma brucei beta tubulin 0.0055 0.0523 0.2985
Echinococcus multilocularis oxidoreductase 0.0019 0.0038 0.0036
Giardia lamblia Beta tubulin 0.0055 0.0523 0.1191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.4114 0.617
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0038 0.0017
Loa Loa (eye worm) hypothetical protein 0.0251 0.3133 0.4937
Mycobacterium tuberculosis Possible oxidoreductase 0.0019 0.0038 0.0017
Echinococcus multilocularis tubulin alpha chain 0.0021 0.0075 0.0073
Onchocerca volvulus 0.004 0.0322 0.0482
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0081 0.012
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0038 0.0017
Echinococcus granulosus tubulin epsilon chain 0.0021 0.0075 0.0073
Mycobacterium leprae Possible regulatory protein 0.0027 0.0155 0.0628
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0201 0.02
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0081 0.0126
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0038 0.0036
Leishmania major hypothetical protein, conserved 0.0033 0.0232 0.1246
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0019 0.0038 0.0036
Trypanosoma cruzi epsilon tubulin, putative 0.0021 0.0075 0.0309
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.0038 0.009
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0038 0.0017
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0021
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Plasmodium vivax SET domain protein, putative 0.0065 0.0653 0.7063
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0451 0.5811 0.9161
Schistosoma mansoni hypothetical protein 0.0033 0.0232 0.023
Plasmodium vivax tubulin gamma chain, putative 0.0021 0.0075 0.0784
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0105 0.0162
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0441 0.044
Echinococcus multilocularis Tubulin beta 2C chain 0.0055 0.0523 0.0522
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Entamoeba histolytica tubulin family protein 0.0055 0.0523 0.1191
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0322 0.0336
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.3133 0.3131
Echinococcus multilocularis microtubule associated protein 2 0.0765 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0081 0.008
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0139 0.1646 0.2592
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0209 0.0208
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0154 0.0152
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.1169 0.1168
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0038 0.0036
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0965 0.0963
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0019 0.0038 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0322 0.032
Mycobacterium tuberculosis Conserved protein 0.004 0.0322 0.0336
Onchocerca volvulus 0.0053 0.0489 0.0734
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.0135
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0322 0.0336
Trichomonas vaginalis tubulin beta chain, putative 0.0021 0.0075 0.0056
Trichomonas vaginalis tubulin beta chain, putative 0.0055 0.0523 0.0735
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0154 0.0152
Leishmania major hypothetical protein, conserved 0.0019 0.0038 0.009
Schistosoma mansoni hypothetical protein 0.0368 0.4692 0.4691
Echinococcus multilocularis lysine specific demethylase 5A 0.0103 0.1158 0.1157
Echinococcus granulosus hypothetical protein 0.0019 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0274 0.3448 0.5434
Entamoeba histolytica tubulin family protein 0.0055 0.0523 0.1191
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0042 0.0217
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.012 0.1076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0181 0.0282
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0408 0.5228 0.5227
Trichomonas vaginalis tubulin epsilon chain, putative 0.0021 0.0075 0.0056
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0081 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0038 0.009
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0283 0.155
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0038 0.0036
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0283 0.155
Echinococcus multilocularis Tubulin beta 2C chain 0.0055 0.0523 0.0522
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0055 0.0523 0.0522
Trichomonas vaginalis tubulin gamma chain, putative 0.0021 0.0075 0.0056
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0283 0.3042
Trypanosoma cruzi alpha tubulin, putative 0.0021 0.0075 0.0309
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0019 0.0038 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0322 0.032
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0038 0.0036
Brugia malayi tubulin alpha-2 chain 0.0021 0.0075 0.0115
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0105 0.0101
Loa Loa (eye worm) prolyl 4-hydroxylase 2 0.0023 0.0091 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0081 0.0126
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0038 0.0037
Loa Loa (eye worm) tubulin alpha chain 0.0021 0.0075 0.0115
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.012 0.0109
Loa Loa (eye worm) hypothetical protein 0.0021 0.0075 0.0115
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0002 0.000000048524
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0081 0.0126
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.012 0.1296
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0105 0.0101
Brugia malayi DOMON domain containing protein 0.0053 0.0489 0.0769
Onchocerca volvulus 0.0019 0.0038 0.0054
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.0038 0.009
Loa Loa (eye worm) oxidoreductase 0.0019 0.0038 0.0057
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0081 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.064 0.1007
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0299 0.0395
Echinococcus granulosus tubulin alpha 3 chain 0.0021 0.0075 0.0073
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0038 0.0036
Schistosoma mansoni pyruvate kinase 0.0037 0.0283 0.0281
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0038 0.0036
Onchocerca volvulus 0.0022 0.0081 0.012
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0143 0.1699 1
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0283 0.0371
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0081 0.0126
Leishmania major short chain dehydrogenase-like protein 0.0019 0.0038 0.009
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0019 0.0038 0.0036
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0038 0.009
Mycobacterium leprae conserved hypothetical protein 0.0025 0.012 0.0439
Echinococcus granulosus pyruvate kinase 0.0019 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0038 0.0036
Onchocerca volvulus 0.0088 0.0965 0.1449
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0038 0.009
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0118 0.136 0.1359
Brugia malayi jmjC domain containing protein 0.0107 0.1214 0.1911
Onchocerca volvulus 0.0103 0.1169 0.1757
Schistosoma mansoni zinc finger protein 0.0033 0.0232 0.023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.4114 0.617
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0274 0.3448 0.3446
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0081 0.0126
Mycobacterium tuberculosis Conserved protein 0.004 0.0322 0.0336
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0155 0.0177
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0081 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0155 0.0177
Echinococcus granulosus beta tubulin 0.0055 0.0523 0.0522
Echinococcus multilocularis Tubulin beta 2C chain 0.0055 0.0523 0.0522
Echinococcus multilocularis pyruvate kinase 0.0019 0.0042 0.0041
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0103 0.1169 0.1757
Leishmania major hypothetical protein, conserved 0.0019 0.0038 0.009
Schistosoma mansoni retinal dehydrogenase 0.0019 0.0038 0.0036
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0081 0.008
Loa Loa (eye worm) hypoxia-induced factor 1 0.0327 0.4146 0.6535
Echinococcus granulosus phd:f box containing protein 0.0027 0.0154 0.0152
Onchocerca volvulus 0.0019 0.0038 0.0054
Echinococcus multilocularis transfer RNA-Lys 0.0078 0.0831 0.0829
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0283 0.0443
Echinococcus multilocularis tubulin epsilon chain 0.0021 0.0075 0.0073
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0283 0.155
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0019 0.0038 0.0054
Leishmania major 3-keto-dihydrosphingosine reductase 0.0019 0.0038 0.009
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.0038 0.0036
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0363 0.0361
Chlamydia trachomatis pyruvate kinase 0.0037 0.0283 0.2028
Onchocerca volvulus 0.0019 0.0038 0.0054
Echinococcus multilocularis tubulin alpha chain 0.0021 0.0075 0.0073
Schistosoma mansoni microtubule-associated protein tau 0.0765 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0081 0.0126
Plasmodium vivax JmjC domain containing protein 0.0027 0.0154 0.1647
Brugia malayi hypothetical protein 0.013 0.1521 0.2396
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0019 0.0038 0.009
Echinococcus granulosus peregrin 0.0036 0.027 0.0268
Trypanosoma cruzi tubulin gamma chain 0.0021 0.0075 0.0309
Schistosoma mansoni rab6-interacting 0.0065 0.0651 0.065
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0274 0.3448 0.3446
Mycobacterium ulcerans hypothetical protein 0.004 0.0322 0.0319
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0081 0.0126
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0081 0.008
Onchocerca volvulus 0.0514 0.6645 1
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0019 0.0038 0.0017
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0038 0.0017
Leishmania major hypothetical protein, conserved 0.0019 0.0038 0.009
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0023 0.0033
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Loa Loa (eye worm) tubulin beta-2A chain 0.0055 0.0523 0.0822
Trichomonas vaginalis tubulin alpha chain, putative 0.0021 0.0075 0.0056
Schistosoma mansoni prolyl 4-hydroxylase alpha subunit 1 0.0023 0.0091 0.0089
Trypanosoma brucei epsilon tubulin 0.0021 0.0075 0.0309
Giardia lamblia Fructose-bisphosphate aldolase 0.0324 0.4114 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0021 0.0075 0.0576
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0038 0.009
Schistosoma mansoni zinc finger protein 0.0042 0.0355 0.0354
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0154 0.0152
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0023 0.0021
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.0038 0.009
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.041
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0154 0.0784
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0085 0.0923 1
Schistosoma mansoni tubulin subunit alpha 0.0021 0.0075 0.0073
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0081 0.0126
Loa Loa (eye worm) tubulin alpha chain 0.0021 0.0075 0.0115
Echinococcus multilocularis beta tubulin 0.0055 0.0523 0.0522
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Schistosoma mansoni tubulin subunit beta 0.0055 0.0523 0.0522
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0038 0.0036
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0155 0.0177
Loa Loa (eye worm) hypothetical protein 0.0065 0.0651 0.1024
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0274 0.3448 0.5434
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0038 0.009
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0143 0.1699 0.1698
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.072 0.0718
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0436 0.0434
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0019 0.0038 0.0017
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0038 0.0017
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0143 0.1699 1
Trypanosoma brucei beta tubulin 0.0055 0.0523 0.2985
Echinococcus granulosus tubulin alpha chain 0.0021 0.0075 0.0073
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0038 0.009
Echinococcus granulosus Tubulin beta 2C chain 0.0055 0.0523 0.0522
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0685 0.0683
Schistosoma mansoni tubulin subunit beta 0.0055 0.0523 0.0522
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0019 0.0038 0.041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0322 0.0319
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0019 0.0038 0.0036
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0155 0.0788
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0102 0.1146 0.1145
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0038 0.0036
Entamoeba histolytica hypothetical protein 0.0025 0.012 0.0201
Plasmodium vivax multidomain scavenger receptor, putative 0.0065 0.0651 0.7047
Loa Loa (eye worm) hypothetical protein 0.0088 0.0968 0.1523
Schistosoma mansoni tubulin subunit gamma 0.0021 0.0075 0.0073
Brugia malayi steroid hormone receptor 0.0022 0.0081 0.0126
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0023 0.022
Schistosoma mansoni hypothetical protein 0.0051 0.0471 0.0469
Toxoplasma gondii beta-tubulin, putative 0.0055 0.0523 0.5668
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0274 0.3448 0.5434
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0038 0.009
Schistosoma mansoni polycystin 1-related 0.0065 0.0651 0.065
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0155 0.0177
Loa Loa (eye worm) DOMON domain-containing protein 0.0053 0.0489 0.0769
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0317 0.4019 0.4018
Loa Loa (eye worm) mbt repeat family protein 0.0103 0.1169 0.1841
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0283 0.3062
Brugia malayi Bromodomain containing protein 0.0083 0.0897 0.1412
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0023 0.0033
Brugia malayi beta-lactamase family protein 0.004 0.0322 0.0505
Echinococcus multilocularis pyruvate kinase 0.0029 0.0179 0.0177
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0019 0.0038 0.041
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Schistosoma mansoni jumonji/arid domain-containing protein 0.0107 0.1214 0.1212
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.0038 0.0036
Echinococcus granulosus histone acetyltransferase MYST2 0.0118 0.136 0.1359
Brugia malayi dehydrogenases, short chain protein 9 0.0019 0.0038 0.0057
Brugia malayi hypothetical protein 0.0491 0.6343 1
Schistosoma mansoni hypothetical protein 0.0368 0.4692 0.4691
Loa Loa (eye worm) hypothetical protein 0.013 0.1521 0.2396
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0081 0.008
Brugia malayi Dehydrogenases, short chain protein 30 0.0019 0.0038 0.0057
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0685 0.1077
Giardia lamblia Alpha-tubulin 0.0021 0.0075 0.009
Echinococcus multilocularis pyruvate kinase 0.0037 0.0283 0.0281
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0282 0.0281
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.0038 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0436 0.0434
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0154 0.0152
Schistosoma mansoni myelin transcription factor 1 myt1 0.0118 0.136 0.1359
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0471 0.074
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.0038 0.009
Toxoplasma gondii beta tubulin 0.0055 0.0523 0.5668
Schistosoma mansoni survival motor neuron protein 0.0051 0.0471 0.0469
Echinococcus granulosus tubulin subunit beta 0.0055 0.0523 0.0522
Toxoplasma gondii oxidoreductase, putative 0.0019 0.0038 0.041
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0081 0.0126
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0322 0.0336
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0154 0.0784
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.3133 0.3131
Brugia malayi Tubulin alpha chain 0.0021 0.0075 0.0115
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.013 0.1517 0.1515
Echinococcus granulosus tubulin subunit TubB 0.0021 0.0075 0.0073
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0154 0.0152
Echinococcus multilocularis tubulin subunit beta 0.0055 0.0523 0.0522
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0019 0.0038 0.0054
Trypanosoma brucei alpha tubulin 0.0021 0.0075 0.0309
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0038 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0283 0.0443
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0965 0.0963
Schistosoma mansoni lipoxygenase 0.0201 0.2467 0.2465
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.4114 0.617
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0085 0.0923 0.1453
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.0038 0.009
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.1169 0.1168
Schistosoma mansoni lipoxygenase 0.0317 0.4019 0.4018
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0087 0.0265
Onchocerca volvulus 0.0019 0.0038 0.0054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0102 0.1146 0.1145
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Trichomonas vaginalis tubulin gamma chain, putative 0.0055 0.0523 0.0735
Trypanosoma cruzi ISWI complex protein 0.0033 0.0232 0.1246
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0322 0.0336
Brugia malayi TAR-binding protein 0.0067 0.0685 0.1077
Schistosoma mansoni tubulin subunit beta 0.0055 0.0523 0.0522
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0201 0.02
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0038 0.0017
Echinococcus multilocularis RUN 0.0065 0.0651 0.065
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0155 0.0788
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0651 0.065
Echinococcus granulosus hypothetical protein 0.0019 0.0038 0.0036
Schistosoma mansoni hypothetical protein 0.0031 0.0201 0.02
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0081 0.008
Echinococcus granulosus Tubulin beta 2C chain 0.0055 0.0523 0.0522
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0322 0.043
Echinococcus granulosus intermediate filament protein 0.003 0.0188 0.0186
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0283 0.0275
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0154 0.0152
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0019 0.0038 0.0167
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0154 0.0152
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.0038 0.009
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Loa Loa (eye worm) dehydrogenase 0.0019 0.0038 0.0057
Loa Loa (eye worm) oxidoreductase 0.0019 0.0038 0.0057
Onchocerca volvulus 0.004 0.0322 0.0482
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0019 0.0038 0.0057
Loa Loa (eye worm) oxidoreductase 0.0019 0.0038 0.0057
Schistosoma mansoni alpha tubulin 0.0021 0.0075 0.0073
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0081 0.008
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0441 0.044
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0019 0.0038 0.0057
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0322 0.1783
Loa Loa (eye worm) oxidoreductase 0.0019 0.0038 0.0057
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0209 0.0208
Plasmodium falciparum tubulin beta chain 0.0055 0.0523 0.5559
Schistosoma mansoni tubulin subunit beta 0.0055 0.0523 0.0522
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0436 0.0684
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0081 0.008
Loa Loa (eye worm) oxidoreductase 0.0019 0.0038 0.0057
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Plasmodium falciparum phd finger protein, putative 0.0031 0.0201 0.1982
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.4114 0.617
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0154 0.167
Echinococcus granulosus Tubulin alpha 1 chain 0.0021 0.0075 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0685 0.0683
Echinococcus multilocularis tubulin gamma 1 chain 0.0021 0.0075 0.0073
Trichomonas vaginalis tubulin beta chain, putative 0.0021 0.0075 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0685 0.0683
Loa Loa (eye worm) hypothetical protein 0.0065 0.0651 0.1024
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0011 0.0014
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0081 0.008
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0081 0.008
Mycobacterium leprae conserved hypothetical protein 0.004 0.0322 0.1523
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0653 0.7071
Plasmodium vivax hypothetical protein, conserved 0.004 0.0322 0.3468
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0093 0.1023 0.1611
Trichomonas vaginalis tubulin epsilon chain, putative 0.0055 0.0523 0.0735
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0283 0.1313
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0651 0.065
Schistosoma mansoni single-minded 0.0106 0.1197 0.1195
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0038 0.0036
Brugia malayi dehydrogenases, short chain protein 2 0.0019 0.0038 0.0057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.0412
Onchocerca volvulus 0.0019 0.0038 0.0054
Trypanosoma cruzi epsilon tubulin, putative 0.0021 0.0075 0.0309
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0085 0.0923 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.0038 0.009
Echinococcus granulosus tubulin alpha chain 0.0021 0.0075 0.0073
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0201 0.218
Brugia malayi beta-lactamase family protein 0.004 0.0322 0.0505
Echinococcus multilocularis tubulin alpha chain 0.0021 0.0075 0.0073
Mycobacterium ulcerans hypothetical protein 0.0022 0.0087 0.0056
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0023 0.0247
Echinococcus granulosus tar DNA binding protein 0.0067 0.0685 0.0683
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0081 0.008
Loa Loa (eye worm) DOMON domain-containing protein 0.0053 0.0489 0.0769
Loa Loa (eye worm) hypothetical protein 0.007 0.0728 0.1145
Echinococcus granulosus lamin 0.003 0.0188 0.0186
Onchocerca volvulus 0.0023 0.0091 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0038 0.009
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0019 0.0038 0.009
Echinococcus granulosus Tubulin alpha 1 chain 0.0021 0.0075 0.0073
Echinococcus granulosus pyruvate kinase 0.0019 0.0042 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.4114 0.617
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.0038 0.009
Trypanosoma brucei oxidoreductase-like protein 0.0019 0.0038 0.009
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0283 0.0371
Plasmodium falciparum tubulin gamma chain 0.0021 0.0075 0.0576
Giardia lamblia Pyruvate kinase 0.0037 0.0283 0.0601
Echinococcus multilocularis zinc finger protein 0.0042 0.0355 0.0354
Echinococcus granulosus pyruvate kinase 0.0037 0.0283 0.0281
Echinococcus multilocularis tubulin alpha 1C chain 0.0021 0.0075 0.0073
Trypanosoma brucei alpha tubulin 0.0021 0.0075 0.0309
Toxoplasma gondii alpha-tubulin I, putative 0.0021 0.0075 0.0809
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0322 0.0319
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0038 0.0384
Giardia lamblia Alpha-tubulin 0.0021 0.0075 0.009
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0081 0.012
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0019 0.0038 0.0036
Brugia malayi PHD-finger family protein 0.0031 0.0201 0.0315
Brugia malayi mbt repeat family protein 0.0103 0.1169 0.1841
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0081 0.0126
Loa Loa (eye worm) dehydrogenase 0.0019 0.0038 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Onchocerca volvulus 0.003 0.0188 0.028
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0042 0.0433
Echinococcus granulosus pyruvate kinase 0.0019 0.0042 0.0041
Trypanosoma brucei epsilon tubulin 0.0021 0.0075 0.0309
Leishmania major pteridine reductase 1 0.0019 0.0038 0.009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.072 0.0718
Echinococcus multilocularis beta tubulin 0.0055 0.0523 0.0522
Loa Loa (eye worm) tubulin gamma chain 0.0021 0.0075 0.0115
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.041
Brugia malayi prolyl 4-hydroxylase 0.0023 0.0091 0.0141
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0283 0.0292
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.0038 0.009
Schistosoma mansoni lamin 0.003 0.0188 0.0186
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0085 0.0923 0.1011
Mycobacterium leprae Probable lipase LipE 0.004 0.0322 0.1523
Loa Loa (eye worm) beta-lactamase 0.004 0.0322 0.0505
Loa Loa (eye worm) hypothetical protein 0.0491 0.6343 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0021 0.0075 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0081 0.008
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0019 0.0038 0.009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0436 0.0434
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Echinococcus granulosus tubulin alpha 1C chain 0.0021 0.0075 0.0073
Leishmania major pyruvate kinase 0.0037 0.0283 0.155
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Giardia lamblia PHD finger protein 15 0.0031 0.0201 0.0401
Onchocerca volvulus 0.0027 0.0155 0.023
Schistosoma mansoni rab6-interacting 0.0065 0.0651 0.065
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.072 0.0767
Echinococcus multilocularis tubulin alpha chain 0.0021 0.0075 0.0073
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0322 0.043
Giardia lamblia Beta tubulin 0.0055 0.0523 0.1191
Trypanosoma brucei alpha tubulin 0.0021 0.0075 0.0309
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0282 0.0281
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0385 0.0383
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0038 0.009
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0322 0.043
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0317 0.4019 0.4018
Brugia malayi isocitrate dehydrogenase 0.0018 0.0023 0.0033
Leishmania major hypothetical protein, conserved 0.0019 0.0038 0.009
Echinococcus multilocularis prolyl 4 hydroxylase subunit alpha 1 0.0023 0.0091 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0436 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0081 0.0126
Echinococcus granulosus peroxisome assembly protein 26 0.0021 0.0075 0.0073
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Echinococcus granulosus Tubulin beta 2C chain 0.0055 0.0523 0.0522
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0003 0.0002
Brugia malayi Tubulin gamma chain 0.0021 0.0075 0.0115
Echinococcus granulosus geminin 0.0368 0.4692 0.4691
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0038 0.0036
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0019 0.0038 0.0036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0081 0.008
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0087 0.0135
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.012 0.0578
Brugia malayi Retinol dehydrogenase 12 0.0019 0.0038 0.0057
Loa Loa (eye worm) runx1 0.0062 0.0611 0.0961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0081 0.0126
Echinococcus multilocularis SAM and MBT domain containing protein 0.0103 0.1169 0.1168
Loa Loa (eye worm) oxidoreductase 0.0019 0.0038 0.0057
Echinococcus multilocularis Protein lozenge 0.0062 0.0611 0.061
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0155 0.0788
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0081 0.0126
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.0879 0.0877
Entamoeba histolytica tubulin alpha chain, putative 0.0021 0.0075 0.009
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Loa Loa (eye worm) BEN-1 protein 0.0055 0.0523 0.0822
Echinococcus granulosus beta tubulin 0.0055 0.0523 0.0522
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0324 0.4114 1
Echinococcus multilocularis conserved hypothetical protein 0.0019 0.0038 0.0036
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0038 0.0017
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0019 0.0038 0.0017
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0143 0.1699 1
Onchocerca volvulus 0.003 0.0188 0.028
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0038 0.0036
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0019 0.0038 0.0057
Echinococcus granulosus single minded 2 0.0082 0.0881 0.0879
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0081 0.0126
Loa Loa (eye worm) intermediate filament protein 0.003 0.0188 0.0294
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0023 0.0021
Trypanosoma brucei alpha tubulin 0.0021 0.0075 0.0309
Echinococcus granulosus tubulin alpha chain 0.0021 0.0075 0.0073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Loa Loa (eye worm) hypothetical protein 0.013 0.1521 0.2396
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Echinococcus granulosus tubulin beta 1 chain 0.0055 0.0523 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0155 0.0177
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.072 0.0767
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0038 0.0017
Echinococcus multilocularis Ankyrin 0.0016 0.0004 0.0002
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0143 0.1699 0.1698
Mycobacterium ulcerans beta-lactamase 0.004 0.0322 0.0319
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Loa Loa (eye worm) tubulin beta-4 chain 0.0055 0.0523 0.0822
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0038 0.0036
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0066 0.0484
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Trichomonas vaginalis tubulin, putative 0.0055 0.0523 0.0735
Entamoeba histolytica tubulin gamma chain 0.0021 0.0075 0.009
Onchocerca volvulus 0.0078 0.0831 0.1248
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0081 0.008
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.0038 0.009
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.0038 0.009
Echinococcus granulosus lamin dm0 0.003 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.0274 0.3448 0.5434
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0154 0.1459
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0363 0.0361
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0829 0.0827
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0105 0.0103
Echinococcus granulosus steroid dehydrogenase 0.0019 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Loa Loa (eye worm) tubulin beta chain 0.0055 0.0523 0.0822
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.072 0.0718
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0038 0.009
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0166 0.2009 0.2008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.041
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0155 0.0788
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0283 0.0443
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0141
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Schistosoma mansoni jumonji/arid domain-containing protein 0.0107 0.1214 0.1212
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Toxoplasma gondii tetratricopeptide repeat-containing protein 0.0023 0.0091 0.0988
Trypanosoma brucei ISWI complex protein 0.0033 0.0232 0.1246
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0019 0.0038 0.0017
Trichomonas vaginalis esterase, putative 0.004 0.0322 0.043
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0038 0.0017
Trichomonas vaginalis set domain proteins, putative 0.0514 0.6643 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0021 0.0075 0.0809
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0322 0.0336
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0141
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0019 0.0038 0.0036
Loa Loa (eye worm) DOMON domain-containing protein 0.0053 0.0489 0.0769
Plasmodium falciparum LCCL domain-containing protein 0.0065 0.0651 0.698
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Mycobacterium ulcerans epimerase 0.0022 0.0087 0.0056
Echinococcus granulosus tubulin alpha chain 0.0021 0.0075 0.0073
Trypanosoma brucei 2OG-Fe(II) oxygenase superfamily, putative 0.0023 0.0091 0.0408
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0021
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0143 0.1699 0.4076
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0019 0.0038 0.009
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0154 0.024
Onchocerca volvulus 0.0053 0.0489 0.0734
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0087 0.0056
Plasmodium vivax tubulin alpha chain, putative 0.0021 0.0075 0.0784
Brugia malayi Protein kinase domain containing protein 0.0016 0.0002 0.000000076508
Toxoplasma gondii oxidoreductase, putative 0.0019 0.0038 0.041
Schistosoma mansoni tubulin subunit alpha 0.0021 0.0075 0.0073
Echinococcus multilocularis retinol dehydrogenase 13 0.0019 0.0038 0.0036
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0038 0.0036
Echinococcus granulosus RUN 0.0065 0.0651 0.065
Onchocerca volvulus 0.0065 0.0651 0.0978
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0201 0.0315
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.012 0.0092
Onchocerca volvulus 0.0019 0.0038 0.0054
Mycobacterium ulcerans endonuclease IV 0.0085 0.0923 0.0996
Echinococcus granulosus Tubulin alpha 1 chain 0.0021 0.0075 0.0073
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0081 0.008
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0155 0.0177
Schistosoma mansoni alpha tubulin 0.0021 0.0075 0.0073
Schistosoma mansoni tubulin subunit epsilon 0.0021 0.0075 0.0073
Onchocerca volvulus 0.0019 0.0038 0.0054
Entamoeba histolytica tubulin alpha-1 chain 0.0021 0.0075 0.009
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0685 0.0683
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.0038 0.009
Loa Loa (eye worm) hypothetical protein 0.0153 0.1835 0.2892
Onchocerca volvulus 0.004 0.0322 0.0482
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0019 0.0038 0.0017
Brugia malayi jmjC domain containing protein 0.0166 0.2009 0.3166
Schistosoma mansoni tubulin subunit alpha 0.0021 0.0075 0.0073
Brugia malayi Bromodomain containing protein 0.0163 0.1959 0.3087
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0651 0.065
Echinococcus granulosus histone lysine methyltransferase setb 0.0102 0.1146 0.1145
Echinococcus granulosus tubulin alpha chain 0.0021 0.0075 0.0073
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Brugia malayi Death domain containing protein 0.0016 0.0002 0.000000076508
Trichomonas vaginalis tubulin beta chain, putative 0.0021 0.0075 0.0056
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0103 0.1169 0.1168
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0385 0.0383
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0038 0.009
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0155 0.0177
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0081 0.008
Echinococcus multilocularis transcription factor Dp 1 0.0083 0.0895 0.0893
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0003 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0436 0.0434
Loa Loa (eye worm) tubulin beta-1 chain 0.0055 0.0523 0.0822
Echinococcus multilocularis Tubulin beta 2C chain 0.0055 0.0523 0.0522
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.4114 0.617
Loa Loa (eye worm) oxidoreductase 0.0019 0.0038 0.0057
Brugia malayi hypothetical protein 0.0251 0.3133 0.4937
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0158 0.1902 0.2096
Onchocerca volvulus Sepiapterin reductase homolog 0.0019 0.0038 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0038 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0081 0.008
Echinococcus multilocularis Tubulin beta 2C chain 0.0055 0.0523 0.0522
Echinococcus multilocularis Tubulin alpha 1 chain 0.0021 0.0075 0.0073
Mycobacterium tuberculosis Probable oxidoreductase 0.0685 0.8931 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0621 0.0619
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.4114 0.617
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0154 0.0152
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0155 0.0788
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.0038 0.009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0155 0.0241
Brugia malayi ecdysteroid receptor 0.0022 0.0081 0.0126
Brugia malayi nuclear receptor NHR-88 0.0022 0.0081 0.0126
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0019 0.0038 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0201 0.02
Loa Loa (eye worm) jmjC domain-containing protein 0.0107 0.1214 0.1911
Leishmania major hypothetical protein, unknown function 0.0023 0.0091 0.0408
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0019 0.0038 0.041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0081 0.0126
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0283 0.0423
Echinococcus multilocularis histone acetyltransferase MYST2 0.0118 0.136 0.1359
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0019 0.0038 0.009
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0335 0.0333
Brugia malayi PAS domain containing protein 0.0106 0.1197 0.1884
Schistosoma mansoni lozenge 0.0062 0.0611 0.061
Echinococcus granulosus tubulin alpha 0.0021 0.0075 0.0073
Brugia malayi jmjC domain containing protein 0.0027 0.0154 0.024
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0019 0.0038 0.0036
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0282 0.0281
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0155 0.0788
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0038 0.009
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0155 0.0788
Leishmania major hypothetical protein, conserved 0.0027 0.0154 0.0784
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0283 0.0423
Brugia malayi beta-lactamase 0.004 0.0322 0.0505
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0023 0.0021
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0154 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0081 0.0126
Echinococcus multilocularis tubulin alpha 1C chain 0.0021 0.0075 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0155 0.0177
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.072 0.4158
Echinococcus multilocularis tubulin alpha 3 chain 0.0021 0.0075 0.0073
Loa Loa (eye worm) hypothetical protein 0.0491 0.6343 1
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0038 0.009
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0201 0.218
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0322 0.1783
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0143 0.1699 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0019 0.0038 0.0017
Echinococcus granulosus polycomb protein SCMH1 0.0103 0.1169 0.1168
Loa Loa (eye worm) hypothetical protein 0.0085 0.0923 0.1453
Trichomonas vaginalis tubulin alpha chain, putative 0.0055 0.0523 0.0735
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0154 0.0152
Schistosoma mansoni tubulin subunit beta 0.0055 0.0523 0.0522
Echinococcus granulosus Tubulin beta 2C chain 0.0055 0.0523 0.0522
Trichomonas vaginalis tubulin beta chain, putative 0.0021 0.0075 0.0056
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Loa Loa (eye worm) hypothetical protein 0.0083 0.0899 0.1415
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0155 0.0177
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Onchocerca volvulus 0.0065 0.0651 0.0978
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.3193 0.3559
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.0038 0.0036
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0081 0.008
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Brugia malayi RNA binding protein 0.0067 0.0685 0.1077
Echinococcus granulosus oxidoreductase 0.0019 0.0038 0.0036
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0023 0.0091 0.0408
Chlamydia trachomatis endonuclease IV 0.0085 0.0923 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0283 0.0443
Loa Loa (eye worm) doublecortin family protein 0.0065 0.0651 0.1024
Loa Loa (eye worm) hypothetical protein 0.0088 0.0965 0.1518
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0038 0.0036
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0081 0.008
Echinococcus multilocularis tubulin subunit TubB 0.0021 0.0075 0.0073
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Echinococcus multilocularis pyruvate kinase 0.0037 0.0283 0.0281
Leishmania major beta tubulin 0.0055 0.0523 0.2985
Brugia malayi nuclear hormone receptor 0.0022 0.0081 0.0126
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0081 0.008
Loa Loa (eye worm) alpha-tubulin 0.0021 0.0075 0.0115
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0274 0.3448 0.3446
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0038 0.009
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0023 0.0091 0.0988
Loa Loa (eye worm) hypothetical protein 0.0118 0.136 0.2142
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Toxoplasma gondii ABC1 family protein 0.004 0.0322 0.3486
Loa Loa (eye worm) hypothetical protein 0.003 0.0188 0.0294
Loa Loa (eye worm) BEN-1 protein 0.0055 0.0523 0.0822
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Brugia malayi alpha-tubulin 0.0021 0.0075 0.0115
Onchocerca volvulus 0.0019 0.0038 0.0054
Echinococcus granulosus transcription factor Dp 1 0.0083 0.0895 0.0893
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0441 0.044
Schistosoma mansoni carbonyl reductase 0.0019 0.0038 0.0036
Loa Loa (eye worm) oxidoreductase 0.0019 0.0038 0.0057
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0154 0.024
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0155 0.0153
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0154 0.0152
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0322 0.043
Plasmodium falciparum alpha tubulin 1 0.0021 0.0075 0.0576
Plasmodium falciparum alpha tubulin 2 0.0021 0.0075 0.0576
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0335 0.0525
Echinococcus multilocularis Polycystic kidney disease protein 0.0065 0.0651 0.065
Leishmania major hypothetical protein, conserved 0.0019 0.0038 0.009
Brugia malayi oxidoreductase 0.0019 0.0038 0.0057
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Brugia malayi DOMON domain containing protein 0.0053 0.0489 0.0769
Plasmodium vivax steroid dehydrogenase, putative 0.0019 0.0038 0.0384
Loa Loa (eye worm) hypothetical protein 0.0103 0.1169 0.1841
Brugia malayi jmjC domain containing protein 0.0027 0.0154 0.024
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0143 0.1699 0.1698
Brugia malayi bHLH-PAS transcription factor 0.0078 0.0831 0.1307
Schistosoma mansoni tubulin subunit beta 0.0055 0.0523 0.0522
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Plasmodium vivax tubulin beta chain, putative 0.0055 0.0523 0.5656
Echinococcus granulosus tubulin beta 4A class IVa 0.0055 0.0523 0.0522
Trypanosoma brucei beta tubulin 0.0055 0.0523 0.2985
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0322 0.0505
Plasmodium vivax tubulin epsilon chain, putative 0.0021 0.0075 0.0784
Echinococcus multilocularis peroxisome assembly protein 26 0.0021 0.0075 0.0073
Echinococcus granulosus lysine specific demethylase 5A 0.0107 0.1214 0.1212
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0685 0.0683
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0154 0.167
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0002 0.000000048524
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0038 0.009
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0322 0.032
Brugia malayi hypothetical protein 0.0354 0.4512 0.7112
Echinococcus granulosus Ankyrin 0.0016 0.0004 0.0002
Echinococcus granulosus Polycystic kidney disease protein 0.0065 0.0651 0.065
Schistosoma mansoni intermediate filament proteins 0.003 0.0188 0.0186
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.012 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.0038 0.009
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0023 0.0091 0.0988
Brugia malayi hypothetical protein 0.0065 0.0651 0.1024
Schistosoma mansoni carbonyl reductase 0.0019 0.0038 0.0036
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.041
Loa Loa (eye worm) tubulin alpha-2 chain 0.0021 0.0075 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0081 0.008
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0283 0.0423
Echinococcus multilocularis tubulin alpha 0.0021 0.0075 0.0073
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0019 0.0038 0.0017
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Brugia malayi jmjC domain containing protein 0.0027 0.0154 0.024
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0038 0.0036
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0042 0.0459
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0154 0.0152
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0155 0.0153
Toxoplasma gondii beta-1 tubulin, putative 0.0055 0.0523 0.5668
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0653 0.0651
Schistosoma mansoni hypothetical protein 0.0065 0.0651 0.065
Echinococcus multilocularis pyruvate kinase 0.0019 0.0042 0.0041
Echinococcus multilocularis pyruvate kinase 0.0019 0.0042 0.0041
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0081 0.008
Mycobacterium tuberculosis Conserved protein 0.004 0.0322 0.0336
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0038 0.0057
Brugia malayi tubulin alpha chain - mouse 0.0021 0.0075 0.0115
Leishmania major protein kinase, putative 0.0027 0.0155 0.0788
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.0038 0.009
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0154 0.024
Echinococcus multilocularis geminin 0.0368 0.4692 0.4691
Plasmodium falciparum pyruvate kinase 0.0037 0.0283 0.2886
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0299 0.0395
Echinococcus multilocularis peregrin 0.0036 0.027 0.0268
Schistosoma mansoni aryl hydrocarbon receptor 0.0106 0.1197 0.1195
Brugia malayi hypothetical protein 0.0065 0.0651 0.1024
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0188 0.0294
Onchocerca volvulus 0.0065 0.0653 0.098
Loa Loa (eye worm) hypothetical protein 0.0027 0.0154 0.024
Toxoplasma gondii hypoxia- inducible factor prolyl hydroxylase (phd2), putative 0.0023 0.0091 0.0988
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0019 0.0038 0.009
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0038 0.0017
Leishmania major alpha tubulin 0.0021 0.0075 0.0309
Trypanosoma brucei epsilon tubulin 0.0021 0.0075 0.0309
Echinococcus granulosus pyruvate kinase 0.0037 0.0283 0.0281
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.0038 0.0036
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0283 0.155
Leishmania major alpha tubulin 0.0021 0.0075 0.0309

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2 nM Inhibition of human 11betaHSD1 by SPA assay ChEMBL. 18440812
IC50 (binding) = 2 nM Inhibition of human 11betaHSD1 by SPA assay ChEMBL. 18440812
IC50 (binding) = 25 nM Inhibition of mouse 11betaHSD1 by SPA assay ChEMBL. 18440812
IC50 (binding) = 25 nM Inhibition of mouse 11betaHSD1 by SPA assay ChEMBL. 18440812
IC50 (binding) = 503 nM Inhibition of human 11betaHSD2 by SPA assay ChEMBL. 18440812
IC50 (binding) = 503 nM Inhibition of human 11betaHSD2 by SPA assay ChEMBL. 18440812
IC50 (binding) > 4000 nM Inhibition of mouse 11betaHSD2 by SPA assay ChEMBL. 18440812
IC50 (binding) > 4000 nM Inhibition of mouse 11betaHSD2 by SPA assay ChEMBL. 18440812
Inhibition (functional) = 3 % Inhibition of 11betaHSD1 in mouse phamacodynamic model assessed as inhibition of [3H]cortisone to [3H]cortisol at 10 mg/kg, po after 4 hrs ChEMBL. 18440812
Inhibition (functional) = 3 % Inhibition of 11betaHSD1 in mouse phamacodynamic model assessed as inhibition of [3H]cortisone to [3H]cortisol at 10 mg/kg, po after 4 hrs ChEMBL. 18440812
Inhibition (functional) = 35 % Inhibition of 11betaHSD1 in mouse phamacodynamic model assessed as inhibition of [3H]cortisone to [3H]cortisol at 10 mg/kg, po after 1 hr ChEMBL. 18440812
Inhibition (functional) = 35 % Inhibition of 11betaHSD1 in mouse phamacodynamic model assessed as inhibition of [3H]cortisone to [3H]cortisol at 10 mg/kg, po after 1 hr ChEMBL. 18440812

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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