Detailed view for PF3D7_1247800

Basic information

TDR Targets ID: 5512
Plasmodium falciparum, dipeptidyl aminopeptidase 2
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.2171 | Length (AA): 590 | MW (Da): 69642 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00112   Papain family cysteine protease
PF08773   Cathepsin C exclusion domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005764   lysosome  
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
106 486 1cs8 (A) 3 219 20.00 0 1 0.7 0.4
161 191 2eof (A) 8 38 19.00 0.93 0.02 0.382142 -1.67
226 570 2c0y (A) 11 313 27.00 0.00000015 1 0.502346 0.85
499 560 3u8e (A) 161 202 48.00 0.01 0.58 0.101685 0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, Female Gametocyte, Male Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile merozoite, sporozoite, late schizont. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Ring, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, early schizont, late trophozoite. Otto TD PlasmoDB
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_130494)

Species Accession Gene Product
Babesia bovis BBOV_I000540   preprocathepsin c precursor, putative
Babesia bovis BBOV_II000170   cathepsin C precursor, putative
Caenorhabditis elegans CELE_F36D3.9   Protein CPR-2
Cryptosporidium hominis Chro.40239   preprocathepsin c precursor
Cryptosporidium parvum cgd4_2110   preprocathepsin c precursor, putative
Dictyostelium discoideum DDB_G0292462   hypothetical protein
Giardia lamblia GL50803_14566   Dipeptidyl-peptidase I precursor
Homo sapiens ENSG00000109861   cathepsin C
Mus musculus ENSMUSG00000030560   cathepsin C
Neospora caninum NCLIV_041870   hypothetical protein
Plasmodium berghei PBANKA_1460700   dipeptidyl aminopeptidase 2
Plasmodium berghei PBANKA_0931300   dipeptidyl aminopeptidase 1, putative
Plasmodium falciparum PF3D7_1116700   dipeptidyl aminopeptidase 1
Plasmodium falciparum PF3D7_1247800   dipeptidyl aminopeptidase 2
Plasmodium knowlesi PKNH_1467500   dipeptidyl aminopeptidase 2, putative
Plasmodium knowlesi PKNH_0914400   dipeptidyl aminopeptidase 1, putative
Plasmodium vivax PVX_091465   dipeptidyl aminopeptidase 1, putative
Plasmodium vivax PVX_101280   dipeptidyl aminopeptidase 2, putative
Plasmodium yoelii PY02150   Homo sapiens P3ECSL-related
Plasmodium yoelii PY05365   cathepsin c precursor
Schistosoma japonicum Sjp_0207730   Cathepsin C precursor, putative
Schistosoma japonicum Sjp_0207740   ko:K01275 cathepsin C [EC3.4.14.1], putative
Schistosoma mansoni Smp_019030   dipeptidyl-peptidase I (C01 family)
Schmidtea mediterranea mk4.002926.00   Dipeptidyl peptidase 1
Schmidtea mediterranea mk4.002926.03   Dipeptidyl peptidase 1
Toxoplasma gondii TGME49_289620   cathepsin CPC1
Toxoplasma gondii TGME49_267490   preprocathepsin c precursor, putative
Theileria parva TP02_0883   cathepsin C, putative
Theileria parva TP03_0357   cathepsin C, putative
Trichomonas vaginalis TVAG_159150   Clan CA, family C1, cathepsin B-like cysteine peptidase

Essentiality

PF3D7_1247800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0931300 Plasmodium berghei Essential plasmo
PBANKA_1460700 Plasmodium berghei Dispensable plasmo
TGME49_289620 Toxoplasma gondii Probably non-essential sidik
TGME49_267490 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Infectious bronchitis virus 3C-like protease Compounds References
Homo sapiens cathepsin C Compounds References
Mus musculus cathepsin C Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Cathepsin L 334 aa 24.8% 298 aa Compounds References
Bos taurus Cathepsin B 335 aa 23.7% 312 aa Compounds References
Oryctolagus cuniculus Cathepsin K 329 aa 27.1% 269 aa Compounds References
Capra hircus Cathepsin B 335 aa 26.5% 302 aa Compounds References
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 340 aa 22.6% 328 aa Compounds References
Rattus norvegicus Cathepsin K 329 aa 26.5% 268 aa Compounds References
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 340 aa 23.6% 275 aa Compounds References
Trypanosoma cruzi major cysteine proteinase, putative 247 aa 19.9% 221 aa Compounds References
Capra hircus Cathepsin H 335 aa 25.7% 269 aa Compounds References
Trypanosoma brucei cysteine peptidase C (CPC) 340 aa 21.9% 292 aa Compounds References
Rattus norvegicus Cathepsin B 339 aa 27.3% 300 aa Compounds References
Rattus norvegicus Cathepsin S 330 aa 23.0% 283 aa Compounds References
Rattus norvegicus Cathepsin L 334 aa 23.8% 294 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0235 1 1
0.3015 0.7275 1
0.023 1 0.5
0.2796 1 1
0.0138 0.3675 0.6616
0.023 1 0.5
0.161 1 1
0.0618 1 1
0.1333 0.3433 1
0.0233 0.8001 1
0.0664 1 1
0.0266 0.6858 1
0.0248 0.2854 1
0.0134 0.3666 1
0.023 1 0.5
0.5701 1 1
0.035 1 1
0.0127 0.3283 1
0.0582 1 1
0.0235 0.3659 1
0.2705 0.9985 1
0.0143 0.7001 0.5
0.024 0.2535 1
0.023 0.4654 1
0.4657 1 1
0.2357 1 1
0.023 1 0.5
0.2466 0.4782 1
0.097 1 1
0.023 0.512 1
0.023 0.2846 0.5
3.2138 0.4305 1
0.1195 1 1
0.6816 1 1
0.023 0.5 0.5
0.1404 1 0.5
0.599 1 1
0.7556 1 1
0.2375 1 1
0.023 1 0.5
0.3584 0.6489 1
0.023 1 0.5
0.0383 1 1
0.0235 1 1
3.5082 0.3846 1
0.233 1 1
2.9934 1 1
0.2511 0.9217 1
0.023 1 0.5
0.0642 1 1
0.023 1 0.5
0.7339 1 1
0.0117 0.3307 1
0.023 1 1
0.222 0.9209 1
0.6143 1 1
0.0156 0.4995 1
0.031203 1 1
0.023 0.3196 1
0.1182 1 1
0.0143 0.3405 1
0.2881 1 1
0.0272 0.2927 1
0.2969 1 1
0.2635 1 1
0.023 1 1
0.4413 1 1
0.2953 1 1
0.2209 0.7675 1
0.0143 0.5587 1
2.3572 0.3518 1
0.023 1 0.5
0.023 0.6361 1
0.3172 0.983 0.5
0.0238 0.2846 1
0.0373 0.4466 1
0.4217 1 1
0.0817 0.2656 1
0.0608 1 1
0.023 1 0.5
0.5569 0.9239 1
0.2969 1 1
0.0247 0.2559 1
0.0215 1 1
0.023 0.2683 1
0.2244 0.9224 1
0.0128 0.3532 1
0.0382 0.4157 1
0.063 1 1
0.0212 0.6136 1
0.6098 1 1
0.023 0.2679 1
0.0433 1 1
0.3516 0.9749 1
0.1473 1 1
0.7394 1 1
0.023 0.3502 1
0.0156 0.4995 1
0.023 1 0.5
0.1668 0.2538 1
0.0235 1 1
0.0245 0.5715 0.5232
0.023 0.7056 1
0.023 0.7075 1
0.0961 1 1
0.0341 0.3034 0.5965
0.1734 1 1
0.0496 0.499 1
0.5351 1 1
0.8186 1 1
0.0507 0.2519 1
0.0248 0.2562 1
0.0238 0.2547 1
0.1742 1 1
0.0143 1 1
0.023 1 1
0.0591 0.3201 1
3.2346 0.5716 1
0.339 1 1
0.0493 0.2507 1
0.2972 1 1
0.1077 1 1
0.3516 0.9749 1
0.023 0.515 1
1.0567 1 1
0.0143 0.4647 0.5
0.6426 1 1
0.0983 1 1
0.0534 0.2785 1
0.6881 1 1
0.1719 1 1
0.2969 1 1
0.1905 1 1
0.0238 0.2881 1
0.2705 0.9985 1
0.025 1 1
0.0143 0.3294 0.1388
0.2209 0.7675 1
0.5337 1 1
0.023 1 0.5
0.0445 1 1
3.5082 0.3846 1
0.023 0.2679 1
0.2466 0.4782 1
0.7887 1 1
0.023 0.2773 1
0.023 0.8532 1
0.0591 0.3201 1
0.6087 1 1
0.5701 1 1
0.5644 1 1
0.0233 0.3128 1
0.3584 0.6489 1
0.5365 1 1
0.025 1 1
0.0296 0.2882 0.6678
2.5862 1 1
0.1482 0.356 1
0.0778 1 1
0.0239 0.2887 1
0.023 1 0.5
0.1392 1 1
0.023 1 1
0.8216 1 1
0.023 0.8254 1
0.2972 1 1
0.947 0.396 1
0.0243 0.4311 0.5
0.3802 1 1
0.023 1 0.5
0.1668 0.2538 1
0.6234 1 1
0.00441349 0.95319 0.5
0.0819 0.8322 1
0.4751 0.3081 1
0.035 1 1
5.9868 0.2974 1
0.023 1 1
0.2521 0.339 1
0.1076 0.4197 1
0.0235 1 1
0.0235 1 1
0.2264 1 1
0.022 0.4811 1
0.0441 0.2829 1
0.025 1 1
0.7708 1 1
0.023 1 0.5
0.0226 0.6945 1
0.023 1 1
0.1074 0.2867 1
0.023 1 1
0.2114 1 1
0.0598 1 1
0.0143 1 1
0.0286 0.3614 0.9684
0.023 1 0.5
0.2357 1 1
0.6625 1 1
0.0156 0.4995 1
0.1025 0.3055 1
0.5701 1 1
0.2209 0.7675 1
0.063 1 1
0.0788 0.9428 1
0.0238 0.2547 1
0.0441 0.2829 1
0.2969 1 1
0.023 1 1
3.2332 0.3663 1
0.5342 1 1
0.0443 0.3302 0.5
0.2809 0.3348 1
0.0239 1 1
1.0567 1 1
0.0255 0.3629 1
0.38 1 1
0.0375 0.9969 1
0.023 0.2558 1
0.3531 1 1
0.0507 0.2519 1
0.5336 1 1
0.023 1 0.5
0.0809 0.8534 0.5
0.2809 0.3348 1
0.1698 1 1
0.023 1 1
0.023 1 1
0.023 1 0.5
0.2253 1 1
0.4617 1 1
0.2395 1 1
0.0156 0.4995 1
0.012 0.4212 1
0.6087 1 1
3.2346 0.5716 1
0.7635 1 1
0.6186 1 1
0.0245 0.5825 0.5345
0.023 1 0.5
0.699 1 1
0.0626 1 1
0.0304 0.786 1
0.0611 1 1
0.1849 1 1
0.0488 0.2933 1
0.0235 1 1
0.2244 0.9224 1
0.0246 0.5819 1
0.4206 1 1
0.2521 0.339 1
0.023 1 0.5
0.023 1 0.5
0.7826 1 1
0.4938 1 1
0.0153 0.3408 1
0.1084 1 1
0.063 1 1
0.0369 0.2826 1
0.2304 1 1
0.023 1 0.5
0.0972 0.6928 1
0.4632 1 1
0.3273 1 1
0.0253 0.2811 1
0.0427 0.3116 0.5
0.0528 0.2548 1
0.6206 1 1
0.0237 1 1
0.0389 0.2741 1
0.6143 1 1
0.5388 0.5622 1
0.1473 1 1
0.2969 1 1
0.023 1 0.5
0.4369 1 1
0.023 1 1
0.4632 1 1
0.0691 1 1
0.4415 1 1
0.0645 1 1
0.2137 1 1
0.2378 1 1
0.0238 0.3244 1
0.6127 1 1
0.023 0.2803 1
0.0238 1 1
0.0389 0.2741 1
0.5644 1 1
0.5225 1 1
0.0657 0.3596 1
0.0293 0.2992 0.6488
0.2304 1 1
0.0156 0.4995 1
0.023 1 0.5
0.0303 0.3359 0.5997
0.2051 1 0.5
0.0165 0.3007 1
0.0137 0.3398 1
0.4351 1 1
0.4229 1 1
0.023 1 0.5
0.5826 1 1
0.0332 0.3236 0.6309
0.023 1 0.5
0.44 0.6244 1
0.0247 0.287 1
0.5826 1 1
0.0234 0.2802 1
0.0657 1 1
0.7363 1 1
0.7826 1 1
0.023 1 0.5
0.0143 0.4761 1
0.023 0.2558 1
0.023 0.9247 0.5
0.0789 0.9465 1
0.3911 1 1
0.023 0.617 1
0.0226 1 1
0.0258 0.2962 1
0.0324 0.3378 0.612
0.2682 1 1
0.6378 1 1
0.0637 0.7565 1
2.5862 1 1
0.947 0.396 1
0.023 1 0.5
0.0235 1 1
0.0235 1 1
0.2365 1 1
0.0405 0.2734 0.5
0.4215 1 1
0.2318 1 1
0.237 1 1
0.038 0.408 1
0.0275 0.3614 1
0.0285 0.3263 1
0.0235 0.8673 1
2.5862 1 1
0.6234 1 1
0.0264 0.2618 1
0.222 0.9209 1
2.5862 1 1
0.1046 1 1
0.023 1 0.5
0.046 1 1
0.3568 0.4479 1
0.0657 0.3596 1
0.2969 1 1
0.1213 1 1
3.1833 1 1
0.0143 0.3059 1
0.0265 1 1
0.1742 1 1
0.0226 1 1
0.023 1 0.5
0.1333 0.3433 1
0.0206 0.2617 1
0.2018 1 1
0.676 1 1
0.1975 0.3004 1
0.023 1 0.5
0.0379 0.4073 1
0.3882 1 1
0.023 1 1
0.1942 1 1
0.023 0.6906 1
0.023 1 1
0.023 0.5 0.5
0.3934 1 1
0.0638 1 1
0.2114 1 1
0.1742 1 1
0.023 1 0.5
0.0446 1 1
0.023 0.3232 1
0.0169 1 0.5
0.08 1 1
0.023 0.4654 1
0.2705 0.9985 1
0.037 0.2801 0.6588
0.1014 1 1
0.156 1 1
0.023 0.2902 1
0.0628 0.4036 1
0.023 1 1
0.4274 1 1
0.0156 0.4995 1
0.6169 1 1
4.5221 1 1
0.0235 1 1
0.023 1 0.5
3.3664 0.6372 1
0.3593 1 1
0.023 1 0.5
0.6463 1 1
0.0389 0.2741 1
0.4156 1 1
0.023 1 0.5
0.382 0.3066 1
0.023 1 0.5
3.3175 0.63 1
0.0255 0.3398 1
0.0118 0.4166 1
0.023 1 0.5
0.0235 1 1
0.0327 0.3149 0.7267
2.9216 1 1
0.1983 1 1
0.3015 0.7275 1
0.2521 0.339 1
0.5302 1 1
0.5388 0.5622 1
0.1074 0.2867 1
0.1535 1 1
0.023 1 0.5
2.9934 1 1
0.1732 1 1
0.5337 1 1
0.2969 1 1
0.5026 1 1
0.0774 1 1
0.1568 1 1
0.024 0.2535 1
0.2589 1 1
0.1619 1 1
0.0838 1 1
0.3027 1 1
0.023 0.2616 0.5
0.0514 0.3144 0.8245
3.2346 0.5716 1
0.4759 1 1
0.6234 1 1
0.0393 1 1
0.0648 1 1
0.0368 0.6181 1
0.0122 0.2527 0.5
0.6463 1 1
0.0417 0.5784 0.5
0.023 1 1
0.023 1 0.5
0.023 1 1
0.0585 1 1
0.023 1 0.5
0.0265 1 1
0.0562 1 1
0.472 1 1
0.2664 1 1
0.273 1 1
0.0248 0.2562 1
0.8216 1 1
0.2809 0.3348 1
0.023 1 1
0.023 1 0.5
0.0324 0.3378 0.612
0.023 0.279 1
0.0788 0.8317 1
0.0206 1 1
0.0417 0.3568 0.3553
0.023 0.3502 1
0.1777 1 1
0.023 1 0.5
0.023 1 0.5
0.0443 0.3302 0.5
0.0706 1 0.5
0.0327 0.3149 0.7267
0.2318 1 1
0.3615 1 1
0.023 1 0.5
0.023 1 0.5
0.0462 0.6783 1
0.322 1 1
0.5569 0.9239 1
0.382 0.3066 1
0.023 0.2687 1
0.0235 1 1
0.023 0.3658 1
0.023 0.5 0.5
0.0197 0.2644 1
0.023 1 1
0.0639 1 1
0.0464 0.4963 1
0.4309 1 1
0.2536 0.8813 1
0.023 1 0.5
0.1166 0.3866 1
0.5644 1 1
0.1549 1 1
0.1012 1 0.5
0.0648 1 1
0.4632 1 1
0.106 1 1
0.0183 0.4958 1
0.3376 1 1
0.2114 1 1
0.6276 1 1
0.2796 1 1
0.023 1 0.5
0.6343 1 1
0.0235 1 1
0.0226 1 1
0.025 1 1
0.023 0.6946 1
0.0247 0.4345 0.5
0.023 1 1
0.6169 1 1
0.6195 1 1
0.0235 1 1
0.023 1 0.5
0.369 1 1
0.575 1 1
0.6206 1 1
0.0399 0.5089 1
0.023 1 0.5
0.0616 1 0.5
0.023 1 0.5
0.0393 1 0.5
2.3572 0.3518 1
0.5911 1 1
0.023 1 1
0.0979 1 1
0.5376 1 1
0.5607 1 1
0.023 1 0.5
0.0778 1 1
0.2969 1 1
0.0129 0.3625 1
0.023 1 0.5
0.0247 0.2559 1
0.3778 0.8068 1
0.0235 1 1
0.0272 0.2862 1
0.2809 0.3348 1
0.5361 1 1
0.1076 0.4197 1
0.0232 1 1
0.2969 1 1
0.2593 1 1
0.6198 1 1
0.5289 1 1
0.0233 0.2841 1
0.0254 0.6272 1
0.0218 0.5645 1
0.2804 1 1
0.023 0.7733 1
0.1305 1 1
0.6234 1 1
0.6605 1 1
0.0412 1 1
0.0246 0.8152 1
1.0567 1 1
0.0235 1 1
0.947 0.396 1
0.023 1 1
0.0994 1 1
0.023 1 1
0.2052 1 1
0.0235 1 1
0.2589 1 1
0.6165 1 1
0.0162 0.3209 1
0.023 1 0.5
0.023 1 0.5
0.5225 1 1
0.03 0.3614 1
0.0645 0.3994 1
3.4299 1 1
0.023 1 0.5
0.026 0.306 1
0.023 1 1
0.6098 1 1
2.9942 0.426 1
0.023 0.7784 1
0.0235 1 1
0.0373 0.4466 1
0.0142 0.3589 1
0.3518 1 1
0.0573 1 1
0.023 1 0.5
0.0119 0.4304 1
0.1547 1 1
0.0789 1 1
0.6509 1 1
0.3152 1 1
0.0235 1 1
0.0124 0.3253 1
0.023 1 0.5
0.0238 1 1
0.4156 1 1
2.5479 0.3858 1
0.0222 0.3329 1
0.0173 0.8016 1
0.023 0.3452 1
0.0686 0.8155 1
0.3584 0.6489 1
0.395 1 1
0.023 1 0.5
0.023 1 0.5
0.7524 1 1
0.1074 0.2867 1
0.024 0.2865 1
0.2488 1 1
0.2387 1 1
0.726 1 1
0.0324 1 1
2.9561 0.4648 1
0.5926 1 1
0.0235 1 1
0.538 1 1
0.4609 0.6331 1
0.023 1 0.5
0.694 1 1
0.022 0.7645 1
0.3172 0.983 0.5
0.0639 1 1
0.4274 1 1
0.0143 0.679 1
0.2969 1 1
0.4554 1 1
0.1158 1 0.5
0.0911 1 1
0.2658 1 1
0.0235 1 1
0.023 0.4868 1
0.023 0.253 1
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0.0114 0.4212 1
0.2809 0.3348 1
0.0217 1 1
0.035 1 1
0.0584 0.7917 1
0.024 1 1
0.0215 1 1
0.5365 1 1
0.0789 0.9465 1
0.0627 1 1
0.5393 1 1
0.023 0.5408 1
0.023 0.5 0.5
3.8231 1 1
0.025 1 1
3.2346 0.5716 1
0.4632 1 1
0.0206 0.8835 1
0.6661 1 1
0.0393 1 0.5
0.023 1 0.5
1.7328 1 1
0.0818 1 0.5
0.2318 1 1
0.1084 1 1
0.0111 0.6672 1
0.2209 0.7675 1
0.023 1 1
4.5931 1 1
0.0279 0.3059 0.6508
0.0235 1 1
0.4303 1 1
0.1668 0.2538 1
0.3516 1 1
2.5479 0.3858 1
0.0272 0.2927 1
0.0813 0.9286 1
0.023 1 0.5
0.3904 1 1
0.0248 0.2562 1
4.2257 1 1
0.1606 1 0.5
0.023 1 0.5
0.023 1 1
0.2244 0.9224 1
0.4079 1 1
0.6568 1 1
0.0245 0.8215 1
0.2589 1 1
0.2137 1 1
0.022 0.4811 1
0.0832 1 1
0.0889 1 1
0.0235 1 1
0.023 1 0.5
0.2008 1 1
0.0401 0.2502 1
0.023 1 0.5
0.0143 0.8028 0.5
0.2521 0.339 1
0.5151 1 1
0.2521 0.339 1
0.023 1 1
0.023 1 0.5
0.2969 1 1
0.023 1 0.5
0.0496 0.7015 1
0.254 1 1
0.024 0.2535 1
0.0197 1 1
0.4596 1 1
0.0237 0.5293 1
0.5701 1 1
0.2738 1 1
0.023 1 0.5
0.0778 1 1
0.023 0.8402 1
0.023 1 0.5
0.0363 0.3734 1
0.0789 0.9465 1
0.0415 1 1
0.023 1 1
0.0887 1 1
0.6143 1 1
0.2504 1 1
0.0817 0.2656 1
0.023 0.2687 1
0.3137 1 1
0.023 1 1
0.012 0.4565 0.5
0.0894 0.5926 1
0.382 0.3066 1
0.023 1 0.5
0.3306 1 1
0.5302 1 1
0.0111 0.6672 1
0.0378 1 1
0.3611 1 1
0.0441 0.2829 1
0.0118 0.3305 1
0.023 0.46 1
0.0233 0.2874 1
0.0357 0.3132 0.5031
0.4688 1 1
0.222 0.9209 1
0.0237 0.834 0.5
0.6525 1 1
0.5522 1 1
0.2705 0.9985 1
0.1668 0.2538 1
0.023 1 0.5
0.0235 1 1
0.0236 0.287 1
0.6098 1 1
0.0421 0.8435 1
0.024 1 1
0.4388 1 1
0.6636 1 1
0.2705 0.9985 1
0.023 0.7695 1
0.2809 0.3348 1
0.1091 1 0.5
0.038 0.408 1
0.3157 1 1
0.039 1 1
0.0215 1 1
0.0162 1 1
0.0838 1 1
0.0327 0.3149 0.7267
0.3597 1 1
0.023 1 0.5
0.0235 1 1
0.3371 1 0.5
0.2707 0.2951 1
0.035 1 1
0.2521 0.339 1
0.7238 1 1
0.7661 1 1
0.023 0.8894 1
0.2536 0.8813 1
0.5291 1 1
0.0611 0.8952 1
0.2539 1 1
2.3572 0.3518 1
0.023 1 0.5
0.1076 0.4197 1
0.0148 0.6166 1
0.2539 1 1
0.023 0.5856 1
0.0235 0.2705 1
0.5461 1 1
0.2804 1 1
0.1006 1 1
0.3525 0.6531 1
0.4559 1 1
0.029 0.3429 0.7158
0.0657 0.3596 1
0.2769 1 1
0.6534 1 1
0.023 1 1
0.0268 0.9201 1
0.7108 1 1
0.4667 1 1
0.0429 1 1
0.023 1 1
0.8216 1 1
0.023 0.2708 1
0.0809 0.8534 0.5
0.023 1 1
0.0373 0.4466 1
0.023 1 1
0.5261 1 1
0.023 1 0.5
0.023 1 0.5
0.0237 0.2705 1
0.0443 0.3294 0.5
0.023 1 0.5
0.1137 1 1
0.0118 0.2787 1
0.4736 1 1
0.0959 0.6423 1
0.0143 0.3565 1
0.0833 0.8054 1
0.3895 1 0.5
0.0492 0.2607 1
0.1482 0.356 1
0.023 0.6552 1
0.023 0.4467 1
0.4309 1 1
0.0375 0.4091 1
0.6046 1 1
0.6169 1 1
0.2318 1 1
0.317 1 1
0.3131 1 1
0.0431 1 1
0.2969 1 1
0.413 1 1
0.1575 1 1
0.2539 1 1
0.1129 1 1
0.4144 1 1
0.4716 0.6579 1
0.0398 1 1
0.4924 1 1
0.0375 0.6357 1
0.023 1 0.5
0.5365 1 1
0.2521 0.339 1
0.1158 1 0.5
0.6087 1 1
0.3628 1 1
0.5644 1 1
0.0181 1 1
0.0245 0.4131 1
0.035 1 1
0.0829 1 1
0.0437 0.5008 1
0.4565 1 1
0.1076 0.4197 1
0.025 0.5666 0.5292
0.2521 0.339 1
0.035 1 1
0.1076 0.4197 1
0.0236 0.2802 1
0.0143 0.7732 0.5
0.023 1 0.5
0.2387 1 1
0.023 0.5081 1
0.0405 0.2734 0.5
0.0393 1 1
0.1076 0.4197 1
0.0244 0.6305 1
0.1102 1 1
0.4217 1 1
0.023 0.2902 1
0.023 1 0.5
0.0393 1 1
0.3015 0.7275 1
0.023 0.3502 1
0.021 0.5992 1
0.156 1 1
0.023 1 1
0.1664 1 1
0.4073 1 1
3.2338 0.3659 1
0.1668 0.2538 1
0.0299 0.2799 1
0.5805 1 1
0.0645 1 1
0.0573 1 1
0.0417 0.3568 0.3553
0.0704 0.3975 0.8118
0.023 0.7253 1
0.025 1 1
0.1536 0.8947 1
0.0838 1 1
0.0371 0.3349 1
0.023 1 0.5
0.023 1 1
0.1171 1 1
0.023 0.2866 1
0.5146 1 1
0.7082 1 1
6.697 1 1
0.1668 0.2538 1
0.0924296 0.309096 0.394112
0.0373 1 1
0.44 0.6244 1
0.2969 1 1
0.1938 0.4513 1
0.078 0.7951 1
0.3157 1 1
0.023 1 0.5
0.0303 0.3359 0.5997
0.947 0.396 1
0.023 0.2558 1
0.1975 0.3004 1
0.1182 1 1
0.0437 1 1
0.7699 1 1
0.0234 0.2802 1
0.025 1 1
0.2383 1 1
0.1828 1 0.5
3.3664 0.6372 1
6.2752 1 1
0.023 1 0.5
0.0654 0.4154 0.5
0.023 1 0.5
0.2521 0.339 1
0.023 0.4654 1
0.023 0.2565 1
0.8216 1 1
0.0131 0.4533 1
0.025 1 1
0.0134 0.3704 1
0.2246 1 1
0.023 1 0.5
0.2969 1 1
0.3876 1 1
0.023 1 0.5
0.1536 0.8947 1
0.1682 1 1
0.023 0.8709 0.5
0.7826 1 1
0.023 1 0.5
0.7734 1 1
0.4734 0.4615 0.5303
0.2068 1 1
0.023 0.7733 1
0.0213 0.4208 1
5.9139 1 1
0.0437 0.5008 1
0.2375 1 1
0.476 1 1
0.023 1 0.5
0.0377 0.6482 1
0.0235 1 1
0.1166 0.3866 1
0.1171 1 1
0.023 0.3196 1
1.7328 1 1
0.0205 0.2899 1
0.0264 0.2618 1
0.1099 1 0.5
0.023 0.9373 1
0.0117 1 0.5
0.6143 1 1
0.0268 0.7531 1
0.7297 1 1
0.1668 0.2538 1
0.5501 1 1
0.0197 0.2644 1
0.0252 0.3063 1
0.2969 1 1
0.023 1 1
0.0235 0.2705 1
0.0248 0.2682 1
0.1668 0.2538 1
0.4217 1 1
1.0328 1 1
0.023 1 0.5
0.0238 1 1
0.023 0.2914 1
2.5862 1 1
0.0633 0.3274 1
0.0412 1 1
0.0238 0.4279 1
0.2593 1 1
0.0215 1 1
0.1698 1 1
0.4716 0.6579 1
0.0611 0.4097 1
0.0263 0.6358 1
0.0461 0.505 1
0.0241 0.2868 1
0.6378 1 1
0.0162 0.3209 1
0.276 1 1
0.0245 0.5825 0.5345
0.8186 1 1
0.0244 0.255 1
0.0143 0.7759 0.5
0.1013 1 1
0.0245 0.5715 0.5232
0.0232 0.4179 0.5867
0.0393 0.661 1
0.0282 0.595 0.9885
0.0585 1 1
0.118 0.3571 1
0.6185 1 1
0.0645 1 1
0.0324 0.3378 0.612
0.0664 1 1
0.023 1 0.5
0.2152 1 1
0.2809 0.3348 1
0.023 1 0.5
0.0437 0.5008 1
0.2521 0.339 1
0.0237 1 1
0.0363 0.3734 1
0.7802 1 1
0.023 1 1
0.0469 0.3505 1
0.6636 1 1
0.0454 1 1
0.0601 0.3184 1
0.0225 1 0.5
0.0614 0.5286 1
0.023 1 0.5
0.0493 0.2507 1
0.382 0.3066 1
0.0438 0.4732 1
0.023 1 1
0.1077 1 1
0.2664 1 1
0.023 0.2623 0.5
0.1034 1 0.5
3.6841 0.3323 1
6.3526 1 1
0.1532 1 1
0.1084 1 1
0.0357 0.3132 0.5031
0.5061 1 1
0.4944 1 1
0.1938 0.4513 1
0.0385 0.5087 1
0.3189 1 1

Assayability

Assay information

  • Assay for Cathepsin C (3.4.14.1 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.
  • ChEMBL
  • Inhibition of Plasmodium falciparum 3D7 PFL2290w by fluorescence spectrophotometry

Reagent availability

  • Reagent:
  • Target Type Source Notes
    PF3D7_1247800 purified protein BRENDA A protein with this EC number or name or sequence has been purified from Plasmodium falciparum ( 1 )

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier PF3D7_1247800 (Plasmodium falciparum), dipeptidyl aminopeptidase 2
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