Detailed information for compound 1009400

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 457.647 | Formula: C17H13ClINO4
  • H donors: 1 H acceptors: 2 LogP: 3.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1ccc2c(c1)cc(c(=O)o2)C(=O)Oc1cccc(c1)I.Cl
  • InChi: 1S/C17H12INO4.ClH/c18-12-2-1-3-13(8-12)22-16(20)14-7-11-6-10(9-19)4-5-15(11)23-17(14)21;/h1-8H,9,19H2;1H
  • InChiKey: JHKRUQRCNZLPNO-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0274 0.1012
Onchocerca volvulus 0.002 0.0102 0.0377
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0098 0.0196
Echinococcus granulosus dna polymerase eta 0.0016 0.0053 0.0037
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0022 0.0125 0.0157
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.002 0.0102 0.0086
Onchocerca volvulus 0.002 0.0102 0.0377
Trypanosoma cruzi DNA topoisomerase II, putative 0.0022 0.0125 0.0249
Trypanosoma brucei heat shock protein, putative 0.0022 0.0125 0.0249
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0022 0.0125 0.0249
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0102 0.0204
Giardia lamblia Reductase, putative 0.002 0.0102 0.0458
Echinococcus granulosus neutral alpha glucosidase AB 0.0033 0.0274 0.0258
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.002 0.0102 0.0086
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.002 0.0102 0.0086
Schistosoma mansoni cpg binding protein 0.0034 0.0285 0.0269
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0098 0.0868
Onchocerca volvulus 0.0058 0.059 0.2182
Plasmodium vivax hypothetical protein, conserved 0.0058 0.059 0.4787
Trypanosoma cruzi cytochrome p450-like protein, putative 0.003 0.023 0.046
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.023 0.0386
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1024 0.1009
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1024 0.1009
Loa Loa (eye worm) oxidoreductase 0.002 0.0102 0.0204
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0164 0.0328
Trichomonas vaginalis D-aminoacylase, putative 0.0058 0.059 0.2182
Schistosoma mansoni hypothetical protein 0.0347 0.4376 0.4367
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.023 0.0576
Onchocerca volvulus 0.002 0.0098 0.0361
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0025 0.0164 0.0606
Leishmania major pteridine reductase 1 0.002 0.0102 0.0204
Echinococcus granulosus retinol dehydrogenase 11 0.002 0.0102 0.0086
Echinococcus multilocularis tar DNA binding protein 0.0091 0.1024 0.1009
Brugia malayi exodeoxyribonuclease III family protein 0.0099 0.1127 0.2253
Echinococcus multilocularis heat shock protein 90 0.0022 0.0125 0.0109
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0023
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.0098 0.0082
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.002 0.0102 0.0107
Trichomonas vaginalis penicillin-binding protein, putative 0.0058 0.059 0.2182
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.002 0.0102 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.059 0.1181
Echinococcus granulosus oxidoreductase 0.002 0.0102 0.0086
Mycobacterium tuberculosis Probable lipase LipE 0.0058 0.059 0.117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0391 0.0782
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0078 0.0857 0.1714
Mycobacterium leprae putative cytochrome p450 0.003 0.023 0.2623
Mycobacterium ulcerans carveol-like dehydrogenase 0.002 0.0102 0.016
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.0098 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0201 0.2459 0.4917
Echinococcus multilocularis neutral alpha glucosidase AB 0.0033 0.0274 0.0258
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0098 0.0196
Loa Loa (eye worm) dehydrogenase 0.002 0.0102 0.0204
Echinococcus multilocularis lysosomal alpha glucosidase 0.015 0.1804 0.1791
Brugia malayi Endoplasmin precursor 0.0022 0.0125 0.0249
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0102 0.0204
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0098 0.0196
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.002 0.0098 0.0196
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.023 0.0576
Trichomonas vaginalis set domain proteins, putative 0.0219 0.2705 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0053 0.0195
Entamoeba histolytica heat shock protein 90, putative 0.0022 0.0125 0.1107
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0102 0.0204
Echinococcus multilocularis retinol dehydrogenase 11 0.002 0.0102 0.0086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0099 0.1127 0.2253
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.023 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0196
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.002 0.0102 0.0204
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0022 0.0125 0.0157
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.002 0.0102 0.0107
Treponema pallidum exodeoxyribonuclease (exoA) 0.0099 0.1127 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0022 0.0125 0.0234
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0102 0.0377
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Entamoeba histolytica short chain dehydrogenase family protein 0.002 0.0102 0.0905
Leishmania major hypothetical protein, conserved 0.002 0.0098 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Echinococcus multilocularis retinol dehydrogenase 13 0.002 0.0102 0.0086
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.023 0.0576
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0025 0.0164 0.0606
Giardia lamblia Inositol 5-phosphatase 4 0.002 0.0098 0.042
Echinococcus granulosus retinol dehydrogenase 11 0.002 0.0102 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0368 0.4648 1
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0102 0.0107
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Leishmania major DNA topoisomerase ii 0.0022 0.0125 0.0249
Echinococcus granulosus heat shock protein 0.0022 0.0125 0.0109
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Mycobacterium ulcerans putative regultory protein 0.0022 0.0125 0.0234
Loa Loa (eye worm) cytochrome P450 0.003 0.023 0.046
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.023 0.0576
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0249
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.002 0.0102 0.0458
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0196
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0053 0.0105
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Leishmania major hypothetical protein, conserved 0.002 0.0102 0.0204
Brugia malayi dehydrogenases, short chain protein 2 0.002 0.0102 0.0204
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.023 0.0386
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.1578 0.1564
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0099 0.1127 0.1113
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.002 0.0102 0.0377
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0022 0.0125 0.0234
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.023 0.0576
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Schistosoma mansoni carbonyl reductase 0.002 0.0102 0.0086
Giardia lamblia Histone acetyltransferase GCN5 0.0024 0.0152 0.0926
Plasmodium vivax endoplasmin, putative 0.0022 0.0125 0.0261
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0058 0.059 0.0575
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Mycobacterium tuberculosis Conserved protein 0.0058 0.059 0.117
Brugia malayi Dehydrogenases, short chain protein 30 0.002 0.0102 0.0204
Giardia lamblia Heat shock protein HSP 90-alpha 0.0022 0.0125 0.067
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0102 0.0107
Mycobacterium ulcerans two component regulator - sensor kinase 0.0022 0.0125 0.0234
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0022 0.013 0.0572
Trypanosoma brucei heat shock protein, putative 0.0022 0.0125 0.0249
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.002 0.0102 0.0204
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Plasmodium vivax heat shock protein 86, putative 0.0022 0.0125 0.0261
Toxoplasma gondii exonuclease III APE 0.0099 0.1127 0.5618
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0098 0.0196
Loa Loa (eye worm) cytochrome P450 family protein 0.0076 0.0831 0.1661
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.002 0.0098 0.0196
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.023 0.0576
Echinococcus multilocularis geminin 0.0347 0.4376 0.4367
Chlamydia trachomatis DNA gyrase subunit B 0.0022 0.0125 0.5
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.023 0.0576
Trypanosoma cruzi short chain dehydrogenase, putative 0.002 0.0102 0.0204
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0098 0.0196
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0125 0.0461
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0022 0.0125 0.0234
Entamoeba histolytica hypothetical protein 0.002 0.0102 0.0905
Schistosoma mansoni endoplasmin 0.0022 0.0125 0.0109
Echinococcus multilocularis traf and tnf receptor associated protein 0.002 0.0098 0.0082
Trichomonas vaginalis inositol monophosphatase, putative 0.0025 0.0164 0.0606
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.002 0.0098 0.0082
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0022 0.0125 0.0234
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.002 0.0102 0.0107
Mycobacterium tuberculosis Conserved protein 0.0058 0.059 0.117
Brugia malayi Pre-SET motif family protein 0.0193 0.2358 0.4717
Mycobacterium ulcerans esterase/lipase LipP 0.0058 0.059 0.1747
Brugia malayi Probable DNA topoisomerase II 0.0022 0.0125 0.0249
Schistosoma mansoni inositol monophosphatase 0.0025 0.0164 0.0148
Brugia malayi beta-lactamase family protein 0.0058 0.059 0.1181
Echinococcus multilocularis deoxyribonuclease 1 2 0.002 0.0098 0.0082
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0022 0.0125 0.5
Trypanosoma cruzi mitochondrial protein 99, putative 0.002 0.0098 0.0196
Echinococcus granulosus tar DNA binding protein 0.0091 0.1024 0.1009
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0025 0.0164 0.0606
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.002 0.0098 0.0196
Giardia lamblia Short-chain dehydrogenase, putative 0.002 0.0102 0.0458
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.023 0.0576
Trypanosoma cruzi cytochrome P450, putative 0.0076 0.0831 0.1661
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Trypanosoma brucei heat shock protein, putative 0.0022 0.0125 0.0249
Leishmania major pantothenate kinase subunit, putative 0.002 0.0098 0.0196
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0022 0.0125 0.0466
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.002 0.0102 0.0204
Plasmodium falciparum DNA gyrase subunit B 0.0022 0.0125 0.0261
Echinococcus granulosus integrin alpha ps 0.0022 0.0127 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.023 0.0386
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0098 0.0196
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0099 0.1127 0.2253
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0036 0.0304 0.0608
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0274 0.1012
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0022 0.0125 0.0261
Echinococcus multilocularis synaptojanin 1 0.002 0.0098 0.0082
Onchocerca volvulus 0.002 0.0102 0.0377
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0102 0.016
Loa Loa (eye worm) transcription factor SMAD2 0.0201 0.2459 0.4917
Loa Loa (eye worm) hypothetical protein 0.0058 0.059 0.1181
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0274 0.1012
Trichomonas vaginalis ap endonuclease, putative 0.0099 0.1127 0.4165
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0058 0.059 0.1181
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0091 0.1024 0.2048
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0125 0.0461
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0098 0.0196
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0102 0.0905
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Echinococcus granulosus hypothetical protein 0.002 0.0102 0.0086
Trypanosoma brucei heat shock protein 90, putative 0.0022 0.0125 0.0249
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0196
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0098 0.0868
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0089 0.1005 0.099
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.002 0.0098 0.0361
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0125 0.0461
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.0098 0.0361
Onchocerca volvulus 0.002 0.0102 0.0377
Loa Loa (eye worm) oxidoreductase 0.002 0.0102 0.0204
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0099 0.1127 0.2338
Echinococcus multilocularis integrin alpha ps 0.0022 0.0127 0.0111
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.002 0.0102 0.0377
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0102 0.0377
Mycobacterium tuberculosis Probable esterase LipL 0.0058 0.059 0.117
Schistosoma mansoni heat shock protein 0.0022 0.0125 0.0109
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0102 0.0107
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0022 0.0125 0.0147
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Loa Loa (eye worm) hypothetical protein 0.0022 0.0127 0.0254
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0207 0.0191
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.023 0.0576
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0053 0.0195
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0099 0.1127 0.1113
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.023 0.0576
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0022 0.0125 0.0222
Schistosoma mansoni synaptojanin 0.002 0.0098 0.0082
Schistosoma mansoni cript-related 0.002 0.0098 0.0082
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0164 0.0328
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0026 0.0181 0.0453
Leishmania major RNA-editing complex protein MP100, putative 0.002 0.0098 0.0196
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0102 0.0107
Leishmania major endonuclease/exonuclease protein-like protein 0.002 0.0098 0.0196
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0207 0.0596
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Onchocerca volvulus 0.002 0.0102 0.0377
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0274 0.1012
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0102 0.0204
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.0414
Loa Loa (eye worm) hypothetical protein 0.0058 0.059 0.1181
Entamoeba histolytica heat shock protein 90, putative 0.0022 0.0125 0.1107
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0102 0.0107
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.002 0.0102 0.0204
Schistosoma mansoni hypothetical protein 0.0347 0.4376 0.4367
Brugia malayi oxidoreductase 0.002 0.0102 0.0204
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Echinococcus granulosus heat shock protein 90 0.0022 0.0125 0.0109
Mycobacterium ulcerans ketoacyl reductase 0.002 0.0102 0.016
Echinococcus granulosus histone acetyltransferase KAT2B 0.0026 0.0181 0.0165
Toxoplasma gondii ABC1 family protein 0.0058 0.059 0.2689
Loa Loa (eye worm) TOPoisomerase family member 0.0022 0.0125 0.0249
Schistosoma mansoni cpg binding protein 0.0034 0.0285 0.0269
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.002 0.0102 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0102 0.0204
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0089 0.1005 0.099
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.002 0.0102 0.0086
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0758 0.1515
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0274 0.1012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0058 0.059 0.0575
Schistosoma mansoni microtubule-associated protein tau 0.0778 1 1
Echinococcus multilocularis 0.003 0.023 0.0214
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0125 0.0261
Mycobacterium ulcerans hypothetical protein 0.0058 0.059 0.1747
Leishmania major short chain dehydrogenase-like protein 0.002 0.0102 0.0204
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.002 0.0102 0.0086
Mycobacterium ulcerans beta-lactamase 0.0058 0.059 0.1747
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.002 0.0102 0.0905
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Mycobacterium tuberculosis Probable exported protein 0.002 0.0098 0.0098
Brugia malayi Glycosyl hydrolases family 31 protein 0.015 0.1804 0.3607
Plasmodium vivax steroid dehydrogenase, putative 0.002 0.0102 0.004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0748 0.0733
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0022 0.0125 0.0157
Onchocerca volvulus Putative neutral sphingomyelinase 0.002 0.0098 0.0361
Leishmania major oxidoreductase-like protein 0.002 0.0102 0.0204
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0022 0.0125 0.0249
Trichomonas vaginalis DNA topoisomerase II, putative 0.0022 0.0125 0.0461
Mycobacterium tuberculosis Possible ketoacyl reductase 0.002 0.0102 0.0107
Loa Loa (eye worm) hypothetical protein 0.0395 0.5 1
Schistosoma mansoni carbonyl reductase 0.002 0.0102 0.0086
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0023
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0023
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0098 0.0196
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.023 0.0386
Echinococcus multilocularis lysosomal alpha glucosidase 0.015 0.1804 0.1791
Echinococcus granulosus steroid dehydrogenase 0.002 0.0102 0.0086
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1578 0.4956
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0098 0.0196
Schistosoma mansoni integrin alpha-ps 0.0046 0.0442 0.0426
Echinococcus multilocularis neutral sphingomyelinase 0.002 0.0098 0.0082
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0099 0.1127 1
Leishmania major short chain dehydrogenase, putative 0.002 0.0102 0.0204
Plasmodium falciparum DNA topoisomerase 2 0.0022 0.0125 0.0261
Mycobacterium ulcerans dehydrogenase 0.002 0.0102 0.016
Onchocerca volvulus 0.002 0.0102 0.0377
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.023 0.0386
Echinococcus granulosus integrin alpha 3 0.0022 0.0127 0.0111
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0022 0.0125 0.0261
Onchocerca volvulus 0.002 0.0098 0.0361
Onchocerca volvulus 0.0039 0.0342 0.1264
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0395 0.5 0.4992
Onchocerca volvulus 0.002 0.0102 0.0377
Giardia lamblia Hypothetical protein 0.002 0.0102 0.0458
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Brugia malayi Retinol dehydrogenase 12 0.002 0.0102 0.0204
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0098 0.0868
Mycobacterium ulcerans ketoacyl reductase 0.002 0.0102 0.016
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.002 0.0102 0.0107
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0099 0.1127 0.349
Echinococcus multilocularis microtubule associated protein 2 0.0778 1 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0022 0.0125 0.0261
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.059 0.1181
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.002 0.0102 0.004
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0053 0.0468
Brugia malayi hypothetical protein 0.0027 0.0195 0.039
Entamoeba histolytica acetyltransferase, GNAT family 0.0024 0.0152 0.135
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0102 0.0377
Mycobacterium ulcerans lipase LipD 0.0058 0.059 0.1747
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.1578 0.3156
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.002 0.0102 0.0204
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0026 0.0181 0.0668
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0036 0.0304 0.0608
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.0098 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0207 0.0191
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0022 0.0125 0.0157
Toxoplasma gondii heat shock protein 90, putative 0.0022 0.0125 0.0147
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.002 0.0098 0.0196
Schistosoma mansoni ap endonuclease 0.0099 0.1127 0.1113
Trypanosoma cruzi Heat shock protein 83, putative 0.0022 0.0125 0.0249
Onchocerca volvulus 0.002 0.0102 0.0377
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.002 0.0102 0.0107
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.002 0.0102 0.0204
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.002 0.0102 0.0086
Plasmodium falciparum histone acetyltransferase GCN5 0.0024 0.0152 0.0528
Trypanosoma cruzi cytochrome P450, putative 0.0076 0.0831 0.1661
Mycobacterium tuberculosis Conserved protein 0.0022 0.0125 0.0157
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0138 0.1642 0.8432
Brugia malayi heat shock protein 90 0.0022 0.0125 0.0249
Brugia malayi MH1 domain containing protein 0.0014 0.0016 0.0032
Echinococcus granulosus carbonyl reductase 1 0.002 0.0102 0.0086
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0022 0.0125 0.0461
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Schistosoma mansoni steroid dehydrogenase 0.002 0.0102 0.0086
Trypanosoma brucei heat shock protein, putative 0.0022 0.0125 0.0249
Trypanosoma cruzi PAB1-binding protein , putative 0.0042 0.0391 0.0782
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.023 0.0576
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.002 0.0102 0.0086
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.023 0.0386
Loa Loa (eye worm) beta-lactamase 0.0058 0.059 0.1181
Trypanosoma cruzi DNA topoisomerase II, putative 0.0022 0.0125 0.0249
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0102 0.0204
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0102 0.0107
Echinococcus granulosus WW domain containing oxidoreductase 0.002 0.0102 0.0086
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.002 0.0102 0.0023
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0098 0.0196
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0681 0.3182
Schistosoma mansoni ap endonuclease 0.0099 0.1127 0.1113
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0022 0.0125 0.0249
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.002 0.0102 0.0107
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0022 0.0125 0.0461
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.002 0.0098 0.0196
Brugia malayi MH2 domain containing protein 0.0014 0.0016 0.0032
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.002 0.0102 0.0377
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Trypanosoma brucei Heat shock protein 83, putative 0.0022 0.0125 0.0249
Toxoplasma gondii oxidoreductase, putative 0.002 0.0102 0.0023
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0304 0.0288
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0102 0.0107
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.023 0.0386
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0125 0.0249
Trichomonas vaginalis bromodomain-containing protein, putative 0.0026 0.0181 0.0668
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0304 0.0288
Brugia malayi Cytochrome P450 family protein 0.0076 0.0831 0.1661
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Trichomonas vaginalis receptor histidine kinase, putative 0.0022 0.0125 0.0461
Echinococcus granulosus dna polymerase kappa 0.0016 0.0053 0.0037
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.023 0.0722
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0274 0.0548
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0058 0.059 0.1747
Trypanosoma brucei PAB1-binding protein , putative 0.0042 0.0391 0.0782
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0193 0.2358 0.4717
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.002 0.0102 0.0204
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0022 0.0125 0.0147
Onchocerca volvulus 0.0032 0.026 0.0963
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0102 0.0204
Brugia malayi MH2 domain containing protein 0.0014 0.0016 0.0032
Onchocerca volvulus 0.002 0.0102 0.0377
Trichomonas vaginalis Phospholipase C precursor, putative 0.002 0.0098 0.0361
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0395 0.5 0.4992
Trichomonas vaginalis esterase, putative 0.0058 0.059 0.2182
Schistosoma mansoni cpg binding protein 0.0032 0.026 0.0245
Loa Loa (eye worm) RNA binding protein 0.0091 0.1024 0.2048
Loa Loa (eye worm) integrin alpha pat-2 0.0102 0.1172 0.2343
Leishmania major short chain dehydrogenase/reductase, putative 0.002 0.0102 0.0204
Trypanosoma cruzi short chain dehydrogenase, putative 0.002 0.0102 0.0204
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0053 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0098 0.0196
Echinococcus granulosus tumor protein p63 0.0264 0.3283 0.3272
Echinococcus granulosus synaptojanin 1 0.002 0.0098 0.0082
Echinococcus granulosus geminin 0.0347 0.4376 0.4367
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Mycobacterium ulcerans DNA gyrase subunit B 0.0022 0.0125 0.0234
Leishmania major DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.002 0.0098 0.0361
Loa Loa (eye worm) hypothetical protein 0.0046 0.0438 0.0876
Trypanosoma brucei heat shock protein 90, putative 0.0022 0.0125 0.0249
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.1578 0.1564
Onchocerca volvulus Sepiapterin reductase homolog 0.002 0.0102 0.0377
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0058 0.059 0.117
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0058 0.059 0.1181
Onchocerca volvulus 0.0028 0.0207 0.0765
Loa Loa (eye worm) hypothetical protein 0.0058 0.059 0.1181
Trichomonas vaginalis sensor histidine kinase, putative 0.0022 0.0125 0.0461
Trichomonas vaginalis D-aminoacylase, putative 0.0058 0.059 0.2182
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.023 0.046
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.007
Brugia malayi kinase, mitochondrial precursor 0.0395 0.5 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0152 0.0304
Schistosoma mansoni steroid dehydrogenase 0.002 0.0102 0.0086
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Mycobacterium ulcerans short chain dehydrogenase 0.0252 0.313 1
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Mycobacterium tuberculosis Possible two component sensor kinase 0.0022 0.0125 0.0157
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Schistosoma mansoni steroid dehydrogenase 0.002 0.0102 0.0086
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0164 0.0328
Brugia malayi cytochrome P450 0.003 0.023 0.046
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0022 0.0125 0.0109
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.002 0.0102 0.0204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0304 0.0288
Echinococcus granulosus endonuclease exonuclease phosphatase 0.002 0.0098 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0304 0.0288
Onchocerca volvulus 0.002 0.0102 0.0377
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0102 0.0107
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0022 0.0125 0.0157
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.059 0.1181
Schistosoma mansoni steroid dehydrogenase 0.002 0.0102 0.0086
Schistosoma mansoni cytochrome P450 0.003 0.023 0.0214
Loa Loa (eye worm) endoplasmin 0.0022 0.0125 0.0249
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.002 0.0102 0.0905
Brugia malayi Smad1 0.0014 0.0016 0.0032
Loa Loa (eye worm) hypothetical protein 0.0039 0.0342 0.0684
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0022 0.0125 0.0261
Loa Loa (eye worm) cytochrome P450 family protein 0.0076 0.0831 0.1661
Brugia malayi RNA recognition motif domain containing protein 0.0091 0.1024 0.2048
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Trichomonas vaginalis maltase-glucoamylase, putative 0.0033 0.0274 0.1012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0019 0.0086 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0053 0.0037
Loa Loa (eye worm) oxidoreductase 0.002 0.0102 0.0204
Echinococcus granulosus dnaJ subfamily B 0.0461 0.5861 0.5854
Trypanosoma brucei heat shock protein, putative 0.0022 0.0125 0.0249
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.023 0.0576
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.023 0.046
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.016 0.193 1
Leishmania major alpha glucosidase II subunit, putative 0.0033 0.0274 0.0548
Loa Loa (eye worm) inositol-1 0.0025 0.0164 0.0328
Chlamydia trachomatis DNA gyrase subunit B 0.0022 0.0125 0.5
Brugia malayi beta-lactamase family protein 0.0058 0.059 0.1181
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Loa Loa (eye worm) oxidoreductase 0.002 0.0102 0.0204
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0098 0.0196
Trypanosoma brucei oxidoreductase-like protein 0.002 0.0102 0.0204
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0274 0.243
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0022 0.0125 0.0109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0304 0.0288
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0102 0.0086
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.023 0.0576
Leishmania major dehydrogenase-like protein 0.002 0.0102 0.0204
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0098 0.0868
Trypanosoma cruzi short-chain dehydrogenase, putative 0.002 0.0102 0.0204
Mycobacterium leprae Probable two component sensor kinase MprB 0.0022 0.0125 0.0466
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.023 0.0386
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0022 0.0125 0.0461
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0022 0.0125 0.0249
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.002 0.0098 0.0361
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0102 0.0204
Plasmodium falciparum steroid dehydrogenase, putative 0.002 0.0102 0.004
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.002 0.0102 0.0107
Onchocerca volvulus 0.0087 0.0975 0.3603
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Echinococcus multilocularis inositol monophosphatase 1 0.0025 0.0164 0.0148
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0102 0.0086
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.002 0.0102 0.0905
Schistosoma mansoni neutral sphingomyelinase 0.002 0.0098 0.0082
Onchocerca volvulus 0.002 0.0102 0.0377
Echinococcus granulosus hypothetical protein 0.002 0.0102 0.0086
Plasmodium vivax DNA topoisomerase II, putative 0.0022 0.0125 0.0261
Echinococcus multilocularis integrin alpha 3 0.0022 0.0127 0.0111
Toxoplasma gondii LsmAD domain-containing protein 0.0042 0.0391 0.16
Loa Loa (eye worm) oxidoreductase 0.002 0.0102 0.0204
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.023 0.0386
Schistosoma mansoni hypothetical protein 0.002 0.0098 0.0082
Brugia malayi acetyltransferase, GNAT family protein 0.0089 0.1005 0.2009
Leishmania major hypothetical protein, conserved 0.002 0.0102 0.0204
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0098 0.0196
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0102 0.0377
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.023 0.0386
Schistosoma mansoni hypothetical protein 0.0022 0.0127 0.0111
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.002 0.0102 0.0086
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1578 0.4956
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0025 0.0164 0.0362
Trypanosoma brucei heat shock protein, putative 0.0022 0.0125 0.0249
Mycobacterium leprae Probable two-component sensor kinase 0.0022 0.0125 0.0466
Leishmania major hypothetical protein, conserved 0.0022 0.0125 0.0249
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0022 0.0125 0.0157
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Echinococcus multilocularis dna polymerase eta 0.0016 0.0053 0.0037
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.002 0.0102 0.0107
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0395 0.5 0.4992
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.002 0.0098 0.0196
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0098 0.0196
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0022 0.013 0.0168
Leishmania major 3-keto-dihydrosphingosine reductase 0.002 0.0102 0.0204
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Brugia malayi CCR4 0.002 0.0098 0.0196
Toxoplasma gondii DNA topoisomerase 2, putative 0.0022 0.0125 0.0147
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0026 0.0181 0.0806
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.002 0.0102 0.0905
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.002 0.0098 0.0196
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0102 0.0204
Leishmania major cytochrome p450-like protein 0.003 0.023 0.046
Echinococcus granulosus beta LACTamase domain containing family member 0.0058 0.059 0.0575
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.002 0.0102 0.0107
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0022 0.0125 0.0461
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0022 0.0125 0.0222
Brugia malayi Glycosyl hydrolases family 31 protein 0.0033 0.0274 0.0548
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0099 0.1127 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Brugia malayi Cytochrome P450 family protein 0.007 0.0758 0.1515
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0102 0.016
Brugia malayi hypothetical protein 0.002 0.0102 0.0204
Brugia malayi MH2 domain containing protein 0.0201 0.2459 0.4917
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0102 0.0086
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.002 0.0098 0.0196
Schistosoma mansoni alpha-glucosidase 0.013 0.153 0.1516
Schistosoma mansoni pyruvate dehydrogenase 0.0373 0.4713 0.4705
Echinococcus multilocularis dnaJ subfamily B 0.0461 0.5861 0.5854
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0102 0.0905
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.023 0.0576
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0102 0.0204
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.002 0.0102 0.0204
Mycobacterium tuberculosis Probable hydrolase 0.0058 0.059 0.117
Trypanosoma brucei RNA editing exonuclease 2 0.002 0.0098 0.0196
Toxoplasma gondii oxidoreductase, putative 0.002 0.0102 0.0023
Schistosoma mansoni alpha glucosidase 0.0033 0.0274 0.0258
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0099 0.1127 0.2253
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0022 0.0125 0.0157
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.023 0.0386
Leishmania major short chain dehydrogenase, putative 0.002 0.0102 0.0204
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0098 0.0196
Leishmania major hypothetical protein, conserved 0.002 0.0098 0.0196
Giardia lamblia Pms1-like protein 0.0022 0.0125 0.067
Echinococcus multilocularis tumor protein p63 0.0264 0.3283 0.3272
Leishmania major hypothetical protein, conserved 0.002 0.0102 0.0204
Trypanosoma cruzi heat shock protein 85, putative 0.0022 0.0125 0.0249
Mycobacterium tuberculosis Probable oxidoreductase 0.0252 0.313 0.6698
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0053 0.0105
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0098 0.0868
Schistosoma mansoni short-chain dehydrogenase/reductase 0.002 0.0102 0.0086
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0053 0.0105
Leishmania major hypothetical protein, conserved 0.002 0.0098 0.0196
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0207 0.0191
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0098 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0102 0.0204
Loa Loa (eye worm) heat shock protein 90 0.0022 0.0125 0.0249
Leishmania major short chain dehydrogenase/reductase, putative 0.002 0.0102 0.0204
Loa Loa (eye worm) Smad1 0.0014 0.0016 0.0032
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.023 0.0386
Brugia malayi beta-lactamase 0.0058 0.059 0.1181
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.002 0.0098 0.0082
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0102 0.0377
Mycobacterium leprae Probable lipase LipE 0.0058 0.059 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.002 0.0102 0.0204
Schistosoma mansoni carbon catabolite repressor protein 0.002 0.0098 0.0082
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1578 0.4956
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0164 0.0328
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0022 0.0125 0.0234
Toxoplasma gondii carbonyl reductase 1, putative 0.002 0.0102 0.0023
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.026 0.0521
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.002 0.0102 0.016
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.002 0.0098 0.0082
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0099 0.1127 0.2253
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.023 0.0386
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.002 0.0102 0.0377
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0102 0.0204
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.1578 0.332
Brugia malayi RNA binding protein 0.0091 0.1024 0.2048
Echinococcus multilocularis oxidoreductase 0.002 0.0102 0.0086
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.002 0.0102 0.0204
Echinococcus granulosus cpg binding protein 0.0034 0.0285 0.0269
Brugia malayi Dehydrogenases, short chain protein 2 0.002 0.0102 0.0204
Loa Loa (eye worm) hypothetical protein 0.0058 0.059 0.1181
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0099 0.1127 1
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.002 0.0102 0.0107
Schistosoma mansoni alpha-glucosidase 0.013 0.153 0.1516
Onchocerca volvulus 0.002 0.0102 0.0377
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0207 0.0191
Brugia malayi TAR-binding protein 0.0091 0.1024 0.2048
Echinococcus multilocularis retinol dehydrogenase 11 0.002 0.0102 0.0086
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0022 0.0125 0.0461
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0098 0.0196
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0076 0.0831 0.2528
Echinococcus granulosus neutral sphingomyelinase 0.002 0.0098 0.0082
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0019 0.0086 0.007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0058 0.059 0.0575
Schistosoma mansoni hypothetical protein 0.003 0.023 0.0214
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0138 0.1642 0.3285
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.002 0.0102 0.0377
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Brugia malayi CXXC zinc finger family protein 0.0032 0.026 0.0521
Loa Loa (eye worm) hypothetical protein 0.0058 0.059 0.1181
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0102 0.0107
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0207 0.0191
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0105
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0022 0.0125 0.0249
Schistosoma mansoni steroid dehydrogenase 0.002 0.0102 0.0086
Echinococcus granulosus carbonyl reductase 1 0.002 0.0102 0.0086
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0102 0.0204
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1024 0.1009
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.023 0.0576
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.002 0.0102 0.0204
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Schistosoma mansoni nocturnin 0.002 0.0098 0.0082
Schistosoma mansoni heat shock protein 0.0022 0.0125 0.0109
Brugia malayi dehydrogenases, short chain protein 9 0.002 0.0102 0.0204
Loa Loa (eye worm) CYP4Cod1 0.0076 0.0831 0.1661
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0022 0.0125 0.0466
Leishmania major developmentally regulated phosphoprotein-like protein 0.0395 0.5 1
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Onchocerca volvulus 0.0058 0.059 0.2182
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.002 0.0102 0.0204
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.023 0.0386
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0099 0.1127 1
Trypanosoma cruzi pantothenate kinase subunit, putative 0.002 0.0098 0.0196
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.002 0.0102 0.0023
Schistosoma mansoni carbonyl reductase 0.002 0.0102 0.0086
Onchocerca volvulus 0.0058 0.059 0.2182
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0098 0.0196
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0102 0.0204
Trypanosoma brucei developmentally regulated phosphoprotein 0.0395 0.5 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.002 0.0102 0.0377
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0053 0.0037
Schistosoma mansoni integrin alpha-ps 0.0024 0.0152 0.0136
Mycobacterium tuberculosis Probable lipase LipD 0.0058 0.059 0.117
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.002 0.0102 0.0204
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.023 0.0386
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.002 0.0098 0.0196
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0102 0.016
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0098 0.0196
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Mycobacterium tuberculosis Probable dehydrogenase 0.002 0.0102 0.0107
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0102 0.0204
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0053 0.0105
Schistosoma mansoni endoplasmin 0.0022 0.0125 0.0109
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0025 0.0164 0.1456
Leishmania major hypothetical protein, conserved 0.0058 0.059 0.1181
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.002 0.0098 0.0361
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0023
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0022 0.0125 0.0461
Trichomonas vaginalis D-aminoacylase, putative 0.0058 0.059 0.2182
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.023 0.0576
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0098 0.0196
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0016 0.0032
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.002 0.0098 0.0361
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.002 0.0102 0.0204
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.023 0.046
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0098 0.0196
Trypanosoma brucei cytochrome P450, putative 0.0076 0.0831 0.1661
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.002 0.0102 0.0204
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.1578 0.8081
Leishmania major hypothetical protein, conserved 0.0042 0.0391 0.0782
Entamoeba histolytica DNA topoisomerase II, putative 0.0022 0.0125 0.1107
Giardia lamblia hypothetical protein 0.002 0.0098 0.042
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0053 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1024 0.1009
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.023 0.046
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0102 0.0107
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.023 0.0386
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0058 0.059 0.117
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0058 0.059 0.117
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0022 0.0125 0.0461
Brugia malayi Cytochrome P450 family protein 0.003 0.023 0.046
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.002 0.0102 0.016
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Brugia malayi Integrin alpha pat-2 precursor 0.0046 0.0442 0.0884
Leishmania major cytochrome p450-like protein 0.003 0.023 0.046
Schistosoma mansoni steroid dehydrogenase 0.002 0.0102 0.0086
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Entamoeba histolytica sphingomyelinase C precursor, putative 0.002 0.0098 0.0868
Loa Loa (eye worm) hypothetical protein 0.0058 0.059 0.1181
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0022 0.0125 0.0249
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0099 0.1127 0.2253
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0022 0.0125 0.0222
Plasmodium vivax hypothetical protein, conserved 0.002 0.0102 0.004
Mycobacterium ulcerans oxidoreductase 0.002 0.0102 0.016
Mycobacterium leprae Conserved hypothetical protein 0.003 0.023 0.2623
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0022 0.0125 0.0249
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.002 0.0102 0.0086
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0053 0.0105
Trichomonas vaginalis receptor histidine kinase, putative 0.0022 0.0125 0.0461
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0022 0.0125 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0152 0.0304
Trypanosoma brucei DNA topoisomerase ii 0.0022 0.0125 0.0249
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0053 0.0037
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0022 0.0125 0.0249
Schistosoma mansoni integrin alpha 0.0046 0.0442 0.0426
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0138 0.1642 0.3285
Schistosoma mansoni steroid dehydrogenase 0.002 0.0102 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0042 0.0391 0.2849
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.015 0.1804 0.3607
Loa Loa (eye worm) acetyltransferase 0.0089 0.1005 0.2009
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.002 0.0098 0.0196
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0016 0.0032
Mycobacterium ulcerans short-chain type oxidoreductase 0.002 0.0102 0.016
Plasmodium vivax ataxin-2 like protein, putative 0.0042 0.0391 0.2849
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0274 0.1012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.1578 0.1564
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0022 0.0125 0.0157
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.002 0.0098 0.0196
Leishmania major hypothetical protein, conserved 0.002 0.0102 0.0204
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.023 0.0576
Brugia malayi hypothetical protein 0.002 0.0102 0.0204
Leishmania major mitochondrial DNA topoisomerase II 0.0022 0.0125 0.0249
Trichomonas vaginalis steroid dehydrogenase, putative 0.002 0.0102 0.0377
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.023 0.0576
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0102 0.0204
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.0098 0.0361
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0102 0.0204
Schistosoma mansoni inositol monophosphatase 0.0025 0.0164 0.0148
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0033 0.0274 0.0961
Trypanosoma cruzi mitochondrial protein 99, putative 0.002 0.0098 0.0196
Schistosoma mansoni pyruvate dehydrogenase 0.0395 0.5 0.4992
Echinococcus granulosus traf and tnf receptor associated protein 0.002 0.0098 0.0082
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0102 0.016
Mycobacterium leprae conserved hypothetical protein 0.0058 0.059 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0098 0.0196
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Trichomonas vaginalis ap endonuclease, putative 0.0099 0.1127 0.4165
Schistosoma mansoni steroid dehydrogenase 0.002 0.0102 0.0086
Mycobacterium tuberculosis Probable two component sensor kinase 0.0022 0.0125 0.0157
Onchocerca volvulus 0.002 0.0102 0.0377
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.023 0.0386
Onchocerca volvulus 0.0219 0.2705 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.002 0.0102 0.0204
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0022 0.0125 0.0234
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.002 0.0102 0.0204
Trypanosoma brucei heat shock protein, putative 0.0022 0.0125 0.0249
Entamoeba histolytica short chain dehydrogenase family protein 0.002 0.0102 0.0905
Loa Loa (eye worm) oxidoreductase 0.002 0.0102 0.0204
Brugia malayi Inositol-1 0.0025 0.0164 0.0328
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0196
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.002 0.0102 0.0905
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0274 0.1012
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0098 0.0868
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.023 0.0576
Trypanosoma brucei unspecified product 0.0016 0.0053 0.0105
Brugia malayi Pre-SET motif family protein 0.0028 0.0207 0.0414
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Echinococcus granulosus inositol monophosphatase 1 0.0025 0.0164 0.0148
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.023 0.0386
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0102 0.0204
Schistosoma mansoni short chain dehydrogenase 0.002 0.0102 0.0086
Echinococcus granulosus carbonyl reductase 1 0.002 0.0102 0.0086
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0053 0.0105
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0022 0.0125 0.0234
Echinococcus granulosus cytochrome P450 2K1 0.003 0.023 0.0214
Loa Loa (eye worm) oxidoreductase 0.002 0.0102 0.0204
Echinococcus multilocularis integrin alpha ps 0.0046 0.0442 0.0426
Loa Loa (eye worm) oxidoreductase 0.002 0.0102 0.0204
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0022 0.0125 0.0461
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.002 0.0102 0.016
Schistosoma mansoni DNA polymerase eta 0.0016 0.0053 0.0037
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.002 0.0102 0.0086
Echinococcus multilocularis steroid dehydrogenase 0.002 0.0102 0.0086
Echinococcus multilocularis steroid dehydrogenase 0.002 0.0102 0.0086
Brugia malayi hypothetical protein 0.0042 0.0391 0.0782
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0099 0.1127 1
Echinococcus granulosus integrin alpha ps 0.0046 0.0442 0.0426
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0098 0.0868
Plasmodium falciparum heat shock protein 90 0.0022 0.0125 0.0261
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0053 0.0105
Schistosoma mansoni pyruvate dehydrogenase 0.0373 0.4713 0.4705
Schistosoma mansoni synaptojanin 0.002 0.0098 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0042 0.0391 0.0782
Mycobacterium ulcerans ketoacyl reductase 0.002 0.0102 0.016
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0053 0.0105
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0972 0.0957
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0125 0.0249
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0138 0.1642 0.3285
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Loa Loa (eye worm) hypothetical protein 0.0078 0.0857 0.1714
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.002 0.0098 0.0082
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0102 0.0377
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0102 0.0107
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0033 0.0274 0.0548
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0098 0.0868
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.023 0.0386
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Schistosoma mansoni steroid dehydrogenase 0.002 0.0102 0.0086
Trichomonas vaginalis penicillin-binding protein, putative 0.0058 0.059 0.2182
Trypanosoma cruzi heat shock protein 85, putative 0.0022 0.0125 0.0249
Schistosoma mansoni steroid dehydrogenase 0.002 0.0102 0.0086
Loa Loa (eye worm) oxidoreductase 0.002 0.0102 0.0204
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.1578 0.1564
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0102 0.016
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0207 0.0191
Leishmania major cytochrome p450-like protein 0.0076 0.0831 0.1661
Echinococcus multilocularis conserved hypothetical protein 0.002 0.0102 0.0086
Toxoplasma gondii heat shock protein HSP90 0.0022 0.0125 0.0147
Loa Loa (eye worm) dehydrogenase 0.002 0.0102 0.0204
Mycobacterium ulcerans oxidoreductase 0.002 0.0102 0.016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0249
Echinococcus granulosus lysosomal alpha glucosidase 0.015 0.1804 0.1791
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0026 0.0181 0.0453
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0274 0.243
Trypanosoma brucei glucosidase, putative 0.0033 0.0274 0.0548
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0102 0.0107
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.002 0.0102 0.0086
Schistosoma mansoni cellular tumor antigen P53 0.0039 0.0342 0.0326
Mycobacterium ulcerans two component sensor kinase MprB 0.0022 0.0125 0.0234
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Schistosoma mansoni DNA topoisomerase II 0.0022 0.0125 0.0109
Brugia malayi Cytochrome P450 family protein 0.0076 0.0831 0.1661
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0304 0.0288
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0025 0.0164 0.0362
Schistosoma mansoni hypothetical protein 0.0461 0.5861 0.5854
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.002 0.0098 0.0868
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0102 0.0204
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.002 0.0102 0.0023
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0102 0.0377
Trichomonas vaginalis sucrase-isomaltase, putative 0.0033 0.0274 0.1012
Plasmodium vivax SET domain protein, putative 0.0028 0.0207 0.1061
Schistosoma mansoni retinal dehydrogenase 0.002 0.0102 0.0086
Leishmania major DNA polymerase eta, putative 0.0016 0.0053 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0304 0.0288
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0102 0.0107
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.002 0.0098 0.0868
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0274 0.0548
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0207 0.0191
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.023 0.0576
Echinococcus multilocularis heat shock protein 0.0022 0.0125 0.0109
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0102 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0204
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0022 0.0125 0.0234
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0098 0.0196
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0022 0.0125 0.0157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Leishmania major hypothetical protein, conserved 0.002 0.0102 0.0204
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0022 0.0125 0.0157
Mycobacterium tuberculosis Conserved protein 0.0058 0.059 0.117
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0102 0.0086
Echinococcus multilocularis cpg binding protein 0.0034 0.0285 0.0269
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.002 0.0102 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0102 0.0377
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0102 0.016
Loa Loa (eye worm) TAR-binding protein 0.0091 0.1024 0.2048
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.002 0.0102 0.0204
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0102 0.0204
Trypanosoma cruzi short-chain dehydrogenase, putative 0.002 0.0102 0.0204
Plasmodium falciparum endoplasmin, putative 0.0022 0.0125 0.0261
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0102 0.0107
Mycobacterium ulcerans dehydrogenase/reductase 0.002 0.0102 0.016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0185 0.0169
Echinococcus granulosus carbonyl reductase 1 0.002 0.0102 0.0086
Trypanosoma cruzi heat shock protein 85, putative 0.0022 0.0125 0.0249
Echinococcus multilocularis integrin alpha ps 0.0046 0.0442 0.0426
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0098 0.0196
Trypanosoma brucei heat shock protein, putative 0.0022 0.0125 0.0249
Brugia malayi MH1 domain containing protein 0.0014 0.0016 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0053 0.0105
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.002 0.0102 0.0086
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.002 0.0102 0.0204
Leishmania major heat shock protein 83-1 0.0022 0.0125 0.0249
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0395 0.5 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0102 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.0042 0.0391 0.2849
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0102 0.0204
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0053 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1024 0.1009

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 25.34 % Antiinvasive activity in human HT1080 cells assessed as number of cells migrated at 1 uM after 24 hrs by Boyden chamber invasion assay ChEMBL. 18329754

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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