Detailed information for compound 1620170

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.359 | Formula: C15H14F7N5S
  • H donors: 1 H acceptors: 3 LogP: 7.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(c1nn2c(n1)nc(cc2Nc1ccc(cc1)S(F)(F)(F)(F)F)C)(F)F
  • InChi: 1S/C15H14F7N5S/c1-3-15(16,17)13-25-14-23-9(2)8-12(27(14)26-13)24-10-4-6-11(7-5-10)28(18,19,20,21)22/h4-8,24H,3H2,1-2H3
  • InChiKey: PYAJSQKAKKJIPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum dihydroorotate dehydrogenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania major dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium knowlesi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium yoelii dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Babesia bovis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei gambiense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium berghei dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium falciparum dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania braziliensis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Theileria parva dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania donovani dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma congolense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania infantum dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530 Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma mansoni dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Neospora caninum dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma japonicum ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0044 0.0098 0.0415
Trypanosoma brucei glucose transporter, putative 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Schistosoma mansoni retinal dehydrogenase 0.0044 0.0098 0.0409
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Schistosoma mansoni hypothetical protein 0.0025 0.0041 0.017
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0044 0.0098 0.0281
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0032 0.0108
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Leishmania major short chain dehydrogenase, putative 0.0044 0.0098 0.0386
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0049 0.0113 0.0474
Trichomonas vaginalis steroid dehydrogenase, putative 0.0044 0.0098 0.0415
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0044 0.0098 0.0415
Plasmodium vivax patched family protein, putative 0.002 0.0024 0.0074
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0787 0.2353 0.3696
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0285 0.0829 0.352
Schistosoma mansoni hypothetical protein 0.0334 0.0978 0.4153
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0041 0.0146
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0044 0.0098 0.0415
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0044 0.0098 0.0415
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0032 0.0041
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.0196 0.0704
Entamoeba histolytica hypothetical protein 0.0044 0.0098 0.0958
Brugia malayi photoreceptor-specific nuclear receptor 0.0049 0.0113 0.0474
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Leishmania major quinonoid dihydropteridine reductase 0.0044 0.0098 0.0386
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0386
Onchocerca volvulus 0.0787 0.2353 1
Entamoeba histolytica hypothetical protein 0.0119 0.0326 0.3369
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0044 0.0098 0.032
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0787 0.2353 0.2352
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Mycobacterium ulcerans short-chain dehydrogenase 0.0044 0.0098 0.0281
Mycobacterium tuberculosis Probable oxidoreductase 0.0044 0.0098 0.032
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0078 0.0202 0.02
Onchocerca volvulus Sepiapterin reductase homolog 0.0044 0.0098 0.0386
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0285 0.0829 0.352
Trichomonas vaginalis glucose transporter, putative 0.0787 0.2353 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0196 0.0742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0049 0.0113 0.0474
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0032 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0098 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0098 0.0386
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0044 0.0098 0.032
Onchocerca volvulus 0.0049 0.0113 0.0451
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Brugia malayi Cytochrome P450 family protein 0.0025 0.0041 0.017
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0035 0.0033
Toxoplasma gondii facilitative glucose transporter GT1 0.0787 0.2353 1
Schistosoma mansoni hypothetical protein 0.0135 0.0373 0.1581
Onchocerca volvulus 0.002 0.0024 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0361 0.1536
Mycobacterium ulcerans oxidoreductase 0.0044 0.0098 0.0281
Schistosoma mansoni carbonyl reductase 0.0044 0.0098 0.0409
Brugia malayi hypothetical protein 0.002 0.0024 0.0098
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0196 0.0704
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0044 0.0098 0.0281
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0044 0.0098 0.121
Schistosoma mansoni hypothetical protein 0.0119 0.0326 0.1378
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0041 0.0038
Loa Loa (eye worm) cytochrome P450 0.0025 0.0041 0.017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0184
Onchocerca volvulus 0.0044 0.0098 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Echinococcus granulosus Niemann Pick C1 protein 0.0326 0.0952 0.1494
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0044 0.0098 0.0409
Schistosoma mansoni hypothetical protein 0.0135 0.0373 0.1581
Leishmania major oxidoreductase-like protein 0.0044 0.0098 0.0386
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0044 0.0098 0.0151
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0045 0.0184
Brugia malayi Patched related family protein 4 0.002 0.0024 0.0098
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Loa Loa (eye worm) histone methyltransferase 0.0016 0.0013 0.0049
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0311 0.12
Echinococcus multilocularis geminin 0.0334 0.0978 0.0977
Leishmania major cathepsin L-like protease 0.0053 0.0127 0.051
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Leishmania major quinonoid dihydropteridine reductase 0.0044 0.0098 0.0386
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0035 0.0141
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0035 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0007 0.003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0044 0.0098 0.0386
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.02 0.0571 0.2405
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0041 0.0038
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0044 0.0098 0.0281
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Brugia malayi Calcitonin receptor-like protein seb-1 0.0285 0.0829 0.352
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0044 0.0098 0.121
Echinococcus granulosus WW domain containing oxidoreductase 0.0044 0.0098 0.0151
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Loa Loa (eye worm) patched family protein 0.002 0.0024 0.0098
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0044 0.0098 0.0096
Echinococcus granulosus carbonyl reductase 1 0.0044 0.0098 0.0151
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0044 0.0098 0.0151
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0044 0.0098 0.0415
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0041 0.0079
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0044 0.0098 0.0409
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0032 0.0041
Echinococcus multilocularis neuropeptide s receptor 0.0357 0.1047 0.1046
Echinococcus multilocularis microtubule associated protein 2 0.0621 0.1849 0.1847
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0049 0.0113 0.0474
Loa Loa (eye worm) hypothetical protein 0.0057 0.0137 0.0578
Trypanosoma cruzi sugar transporter, putative 0.0787 0.2353 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0044 0.0098 0.0386
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0069 0.0287
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0049 0.0113 0.0451
Plasmodium falciparum steroid dehydrogenase, putative 0.0044 0.0098 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Brugia malayi nuclear receptor NHR-88 0.0023 0.0035 0.0141
Mycobacterium leprae Conserved hypothetical protein 0.0025 0.0041 0.0165
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Brugia malayi ecdysteroid receptor 0.0049 0.0113 0.0474
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0035 0.0052
Brugia malayi RNA recognition motif domain containing protein 0.0141 0.0391 0.1657
Echinococcus granulosus cathepsin L cysteine proteinase 0.0014 0.0007 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.0357 0.1047 0.1046
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0049 0.0113 0.0474
Trypanosoma cruzi hexose transporter, putative 0.0787 0.2353 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0014 0.0007 0.0009
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0044 0.0098 0.0415
Toxoplasma gondii oxidoreductase, putative 0.0044 0.0098 0.0386
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0044 0.0098 0.032
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Brugia malayi Cathepsin L-like precursor 0.0014 0.0007 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0311 0.12
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0044 0.0098 0.0409
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0035 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0113 0.0474
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0127 0.051
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0049 0.0113 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0141 0.0391 0.1657
Loa Loa (eye worm) hypothetical protein 0.0076 0.0196 0.0827
Schistosoma mansoni hypothetical protein 0.0334 0.0978 0.4153
Schistosoma mansoni nuclear receptor 0.0023 0.0035 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0049 0.0113 0.0474
Onchocerca volvulus 0.0787 0.2353 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0787 0.2353 1
Leishmania major cathepsin L-like protease 0.0053 0.0127 0.051
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0361 0.1536
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0044 0.0098 0.0415
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0007 0.0024
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0044 0.0098 0.0958
Toxoplasma gondii sugar transporter ST3 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Brugia malayi MH2 domain containing protein 0.0179 0.0506 0.2147
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0114 0.0311 0.1295
Echinococcus granulosus intermediate filament protein 0.0026 0.0045 0.0068
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0109 0.0296 0.1254
Onchocerca volvulus Protein ultraspiracle homolog 0.0049 0.0113 0.0451
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Trypanosoma cruzi cruzipain precursor, putative 0.0053 0.0127 0.051
Loa Loa (eye worm) dehydrogenase 0.0044 0.0098 0.0409
Schistosoma mansoni sugar transporter 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0044 0.0098 0.0386
Brugia malayi cytochrome P450 0.0025 0.0041 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0068 0.0172 0.0726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.0007 0.0024
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0041 0.0079
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0196 0.0805
Loa Loa (eye worm) major facilitator superfamily transporter 0.0787 0.2353 1
Onchocerca volvulus 0.0026 0.0045 0.0161
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0041 0.0038
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Onchocerca volvulus 0.0044 0.0098 0.0386
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0787 0.2353 0.2352
Schistosoma mansoni coup transcription factor 0.0049 0.0113 0.0474
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Onchocerca volvulus 0.0787 0.2353 1
Mycobacterium ulcerans oxidoreductase 0.0044 0.0098 0.0281
Onchocerca volvulus Putative transporter 0.0787 0.2353 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0049 0.0113 0.0112
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0035 0.0141
Brugia malayi Sugar transporter family protein 0.0787 0.2353 1
Schistosoma mansoni cpg binding protein 0.0052 0.0121 0.0508
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Brugia malayi Retinol dehydrogenase 12 0.0044 0.0098 0.0409
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0196 0.0827
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0331 0.0968 0.4109
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Loa Loa (eye worm) cytochrome P450 family protein 0.0142 0.0395 0.1675
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.0668 0.0667
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Onchocerca volvulus 0.002 0.0024 0.0074
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Brugia malayi hypothetical protein 0.0044 0.0098 0.0409
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0032 0.0041
Trypanosoma cruzi hexose transporter, putative 0.0787 0.2353 1
Brugia malayi protein C24B5.3 0.002 0.0024 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0007 0.003
Schistosoma mansoni tar DNA-binding protein 0.0141 0.0391 0.1657
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0041 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0007 0.003
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0386
Echinococcus multilocularis musashi 0.0026 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0232 0.0668 0.2834
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Loa Loa (eye worm) DR-78 0.0023 0.0035 0.0141
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0044 0.0098 0.0386
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.0668 0.1047
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0041 0.0079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.009 0.0238 0.0372
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Schistosoma mansoni patched 1 0.014 0.0388 0.1646
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.0196 0.1997
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0044 0.0098 0.0386
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Schistosoma mansoni hypothetical protein 0.009 0.0238 0.1006
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0044 0.0098 0.0386
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0032 0.0041
Onchocerca volvulus 0.0044 0.0098 0.0386
Onchocerca volvulus 0.0044 0.0098 0.0386
Toxoplasma gondii sugar transporter ST2 0.0787 0.2353 1
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Brugia malayi Patched related family protein 10 0.002 0.0024 0.0098
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0196 0.0827
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Schistosoma mansoni thyroid hormone receptor 0.0049 0.0113 0.0474
Loa Loa (eye worm) CXXC zinc finger family protein 0.0052 0.0121 0.0508
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0044 0.0098 0.0281
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.0113 0.0474
Loa Loa (eye worm) oxidoreductase 0.0044 0.0098 0.0409
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0114 0.0311 0.031
Mycobacterium tuberculosis Probable oxidoreductase 0.0044 0.0098 0.032
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Onchocerca volvulus Glucosylceramidase homolog 0.0131 0.0361 0.151
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0044 0.0098 0.0386
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0035 0.0141
Schistosoma mansoni cytochrome P450 0.0025 0.0041 0.017
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0049 0.0113 0.0474
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0035 0.0033
Echinococcus multilocularis solute carrier family 22 0.0787 0.2353 0.2352
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0474
Schistosoma mansoni sugar transporter 0.0787 0.2353 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0041 0.0146
Loa Loa (eye worm) oxidoreductase 0.0044 0.0098 0.0409
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.014 0.0388 0.1646
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0024
Schistosoma mansoni hypothetical protein 0.0135 0.0373 0.1581
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.02 0.0571 0.2405
Echinococcus granulosus retinol dehydrogenase 11 0.0044 0.0098 0.0151
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0069 0.0157
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0041 0.0079
Schistosoma mansoni carbonyl reductase 0.0044 0.0098 0.0409
Brugia malayi Patched related family protein 12 0.002 0.0024 0.0098
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0032 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0361 0.1536
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0041 0.0079
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Trypanosoma cruzi hexose transporter, putative 0.0787 0.2353 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0014 0.0007 0.0006
Echinococcus multilocularis protein patched 0.014 0.0388 0.0387
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Leishmania major glucose transporter, lmgt1 0.0787 0.2353 1
Schistosoma mansoni glucose transport protein 0.0787 0.2353 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0787 0.2353 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Trypanosoma cruzi short chain dehydrogenase, putative 0.0044 0.0098 0.0386
Brugia malayi Cathepsin L-like precursor 0.0014 0.0007 0.0024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0114 0.0311 0.1236
Onchocerca volvulus 0.0066 0.0166 0.0676
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0196 0.1997
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0361 0.1536
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0049 0.0113 0.0474
Giardia lamblia Sugar-proton symporter 0.0787 0.2353 1
Schistosoma mansoni hypothetical protein 0.0787 0.2353 1
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0137 0.0555
Brugia malayi hypothetical protein 0.0026 0.0043 0.0176
Echinococcus granulosus steroid dehydrogenase 0.0044 0.0098 0.0151
Echinococcus granulosus carbonyl reductase 1 0.0044 0.0098 0.0151
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0114 0.0311 0.0486
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0044 0.0098 0.0958
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0113 0.0474
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0196 0.0704
Schistosoma mansoni microtubule-associated protein tau 0.0621 0.1849 0.7855
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.02 0.0571 0.2405
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0044 0.0098 0.032
Trypanosoma brucei sugar transporter, putative 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0044 0.0098 0.032
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.02 0.0571 0.2424
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0044 0.0098 0.032
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.0202 0.0856
Schistosoma mansoni sugar transporter 0.0787 0.2353 1
Brugia malayi hypothetical protein 0.0787 0.2353 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0032 0.0041
Loa Loa (eye worm) oxidoreductase 0.0044 0.0098 0.0409
Loa Loa (eye worm) hypothetical protein 0.0057 0.0137 0.0578
Brugia malayi Cytochrome P450 family protein 0.0034 0.0069 0.0287
Leishmania major quinonoid dihydropteridine reductase 0.0044 0.0098 0.0386
Brugia malayi nuclear hormone receptor 0.0023 0.0035 0.0141
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0044 0.0098 0.0386
Trypanosoma brucei oxidoreductase-like protein 0.0044 0.0098 0.0281
Trypanosoma cruzi short chain dehydrogenase, putative 0.0044 0.0098 0.0386
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0041 0.0038
Echinococcus granulosus retinol dehydrogenase 11 0.0044 0.0098 0.0151
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0285 0.0829 0.352
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0035 0.0141
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0043 0.0176
Schistosoma mansoni dihydroorotate dehydrogenase 0.02 0.0571 0.2424
Schistosoma mansoni cpg binding protein 0.0055 0.013 0.0546
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0041 0.0038
Onchocerca volvulus 0.002 0.0024 0.0074
Brugia malayi intermediate filament protein 0.0026 0.0045 0.0184
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0041 0.0038
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0196 0.3032
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.0196 0.0704
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0003 0.0003
Mycobacterium ulcerans dehydrogenase 0.0044 0.0098 0.0281
Onchocerca volvulus 0.0127 0.0349 0.1456
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.02 0.0571 0.21
Mycobacterium leprae putative cytochrome p450 0.0025 0.0041 0.0165
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0043 0.0176
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0035 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Toxoplasma gondii patched family protein 0.002 0.0024 0.0074
Mycobacterium ulcerans short-chain dehydrogenase 0.0044 0.0098 0.0281
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.02 0.0571 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0042 0.0092 0.0362
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Trypanosoma brucei glucose transporter, putative 0.0787 0.2353 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.009 0.0238 0.0237
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Echinococcus granulosus neuropeptide receptor A26 0.0357 0.1047 0.1644
Trichomonas vaginalis conserved hypothetical protein 0.0787 0.2353 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0044 0.0098 0.0386
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0032 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0098 0.0386
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0041 0.0079
Schistosoma mansoni glucose transport protein 0.0787 0.2353 1
Brugia malayi ecdysone receptor 0.0023 0.0035 0.0141
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0787 0.2353 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0041 0.0038
Brugia malayi hypothetical protein 0.0127 0.0349 0.1476
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0032 0.0041
Onchocerca volvulus 0.0044 0.0098 0.0386
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0141 0.0391 0.1657
Onchocerca volvulus 0.0044 0.0098 0.0386
Schistosoma mansoni cpg binding protein 0.0055 0.013 0.0546
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Echinococcus granulosus cpg binding protein 0.0055 0.013 0.0202
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0032 0.0132
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0787 0.2353 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0041 0.0079
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Trypanosoma brucei glucose transporter, putative 0.0787 0.2353 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.0007 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Loa Loa (eye worm) patched family protein 0.002 0.0024 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0049 0.0113 0.0474
Leishmania major cytochrome p450-like protein 0.0025 0.0041 0.0146
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0044 0.0098 0.0409
Entamoeba histolytica hypothetical protein 0.0119 0.0326 0.3369
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0044 0.0098 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Loa Loa (eye worm) MH2 domain-containing protein 0.0179 0.0506 0.2147
Toxoplasma gondii aldehyde dehydrogenase 0.0114 0.0311 0.1295
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0044 0.0098 0.0386
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0044 0.0098 0.0415
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0128 0.045
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Toxoplasma gondii transporter, major facilitator family protein 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0474
Onchocerca volvulus 0.0787 0.2353 1
Leishmania major 3-keto-dihydrosphingosine reductase 0.0044 0.0098 0.0386
Echinococcus multilocularis dnaJ subfamily B 0.0735 0.2193 0.2192
Echinococcus multilocularis cathepsin L cysteine protease 0.0014 0.0007 0.0006
Onchocerca volvulus 0.0044 0.0098 0.0386
Loa Loa (eye worm) oxidoreductase 0.0044 0.0098 0.0409
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0032 0.0132
Schistosoma mansoni hypothetical protein 0.009 0.0238 0.1006
Echinococcus multilocularis solute carrier family 22 0.0787 0.2353 0.2352
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0132
Echinococcus granulosus neuropeptide s receptor 0.0357 0.1047 0.1644
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Onchocerca volvulus 0.0022 0.0032 0.0108
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Brugia malayi latrophilin 2 splice variant baaae 0.0195 0.0556 0.2357
Leishmania major hypothetical protein, conserved 0.0044 0.0098 0.0386
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0032 0.0108
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0044 0.0098 0.0409
Echinococcus granulosus GPCR family 2 0.009 0.0238 0.0372
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0032 0.0031
Loa Loa (eye worm) oxidoreductase 0.0044 0.0098 0.0409
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0787 0.2353 1
Onchocerca volvulus 0.0787 0.2353 1
Toxoplasma gondii patched family protein 0.002 0.0024 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0787 0.2353 1
Echinococcus multilocularis sterol regulatory element binding protein 0.014 0.0388 0.0387
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0044 0.0098 0.0409
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0196 0.1997
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0361 0.1536
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0044 0.0098 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0196 0.0704
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0041 0.0038
Trypanosoma cruzi glucose transporter, putative 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0176
Loa Loa (eye worm) patched family protein 0.002 0.0024 0.0098
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0326 0.0952 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0068 0.0172 0.0171
Toxoplasma gondii histone lysine methyltransferase SET1 0.0098 0.0261 0.1082
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0035 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0141 0.0391 0.1657
Schistosoma mansoni thyroid hormone receptor 0.0049 0.0113 0.0474
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0386
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0049 0.0113 0.0175
Toxoplasma gondii patched family protein 0.002 0.0024 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Loa Loa (eye worm) patched family protein 0.002 0.0024 0.0098
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0032 0.0132
Echinococcus multilocularis solute carrier family 22 0.0787 0.2353 0.2352
Trypanosoma brucei short-chain dehydrogenase, putative 0.0044 0.0098 0.0281
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.0098 0.0958
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0068 0.0172 0.0171
Trypanosoma brucei short-chain dehydrogenase, putative 0.0044 0.0098 0.0281
Onchocerca volvulus 0.0787 0.2353 1
Leishmania major quinonoid dihydropteridine reductase 0.0044 0.0098 0.0386
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0049 0.0113 0.0474
Loa Loa (eye worm) hypothetical protein 0.0057 0.0137 0.0578
Echinococcus granulosus sterol regulatory element binding protein 0.014 0.0388 0.0608
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0041 0.0038
Echinococcus multilocularis cysteine protease 0.0014 0.0007 0.0006
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0787 0.2353 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0049 0.0113 0.0112
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0044 0.0098 0.0281
Brugia malayi Cytochrome P450 family protein 0.0034 0.0069 0.0287
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0041 0.0079
Leishmania major short chain dehydrogenase/reductase, putative 0.0044 0.0098 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0044 0.0098 0.0415
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0041 0.0079
Mycobacterium ulcerans ketoacyl reductase 0.0044 0.0098 0.0281
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0044 0.0098 0.032
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Schistosoma mansoni aldehyde dehydrogenase 0.0114 0.0311 0.1316
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0044 0.0098 0.032
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0068 0.0172 0.0726
Echinococcus multilocularis cpg binding protein 0.0055 0.013 0.0128
Onchocerca volvulus 0.0787 0.2353 1
Brugia malayi major facilitator superfamily protein 0.0787 0.2353 1
Trichomonas vaginalis sugar transport protein, putative 0.0787 0.2353 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0049 0.0113 0.0175
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0044 0.0098 0.0386
Loa Loa (eye worm) patched family protein 0.002 0.0024 0.0098
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0035 0.0141
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.0098 0.0096
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0041 0.0146
Brugia malayi dehydrogenases, short chain protein 2 0.0044 0.0098 0.0409
Schistosoma mansoni hypothetical protein 0.009 0.0238 0.1006
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0032 0.0268
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0032 0.0132
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0108 0.0453
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0041 0.0079
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.02 0.0571 0.2322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Brugia malayi hypothetical protein 0.002 0.0024 0.0098
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0041 0.0038
Echinococcus granulosus hypothetical protein 0.0044 0.0098 0.0151
Schistosoma mansoni RAR-like nuclear receptor 0.0049 0.0113 0.0474
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0044 0.0098 0.121
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0049 0.0113 0.0474
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0078 0.0202 0.02
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0137 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0044 0.0098 0.0281
Echinococcus multilocularis steroid dehydrogenase 0.0044 0.0098 0.0096
Brugia malayi Major Facilitator Superfamily protein 0.0787 0.2353 1
Echinococcus granulosus Protein patched homolog 1 0.014 0.0388 0.0608
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0049 0.0113 0.0474
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0069 0.0157
Toxoplasma gondii oxidoreductase, putative 0.0044 0.0098 0.0386
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0569 0.2419
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0178
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0044 0.0098 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.0196 0.0742
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.02 0.0571 0.2353
Loa Loa (eye worm) hypothetical protein 0.0057 0.0137 0.0578
Onchocerca volvulus 0.0787 0.2353 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0049 0.0113 0.0474
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Onchocerca volvulus 0.0044 0.0098 0.0386
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0044 0.0098 0.0409
Leishmania major dehydrogenase-like protein 0.0044 0.0098 0.0386
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0044 0.0098 0.032
Trypanosoma brucei short-chain dehydrogenase, putative 0.0044 0.0098 0.0281
Brugia malayi hypothetical protein 0.0119 0.0326 0.1378
Schistosoma mansoni steroid dehydrogenase 0.0044 0.0098 0.0409
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0119 0.0326 0.0509
Brugia malayi conserved hypotetical protein 0.0023 0.0035 0.0141
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0044 0.0098 0.032
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0787 0.2353 0.2352
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Schistosoma mansoni steroid dehydrogenase 0.0044 0.0098 0.0409
Leishmania major hypothetical protein, conserved 0.0044 0.0098 0.0386
Brugia malayi nuclear receptor NHR-67 0.0023 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0098 0.0386
Echinococcus granulosus geminin 0.0334 0.0978 0.1535
Trypanosoma brucei glucose transporter 1E 0.0787 0.2353 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0044 0.0098 0.0096
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0137 0.0555
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0013 0.0011
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0044 0.0098 0.032
Leishmania major cytochrome p450-like protein 0.0034 0.0069 0.0264
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.009 0.0238 0.0372
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Onchocerca volvulus Protein patched homolog 0.002 0.0024 0.0074
Echinococcus granulosus lamin dm0 0.0026 0.0045 0.0068
Trypanosoma brucei glucose transporter 2A 0.0787 0.2353 1
Onchocerca volvulus 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Loa Loa (eye worm) oxidoreductase 0.0022 0.0032 0.0132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0044 0.0098 0.032
Mycobacterium tuberculosis Possible oxidoreductase 0.0044 0.0098 0.032
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0119 0.0326 0.0324
Brugia malayi hypothetical protein 0.0026 0.0043 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0032 0.0108
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0035 0.0117
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.0202 0.0856
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0044 0.0098 0.0386
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0032 0.0132
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0787 0.2353 1
Echinococcus multilocularis oxidoreductase 0.0044 0.0098 0.0096
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0041 0.0079
Leishmania major short chain dehydrogenase/reductase, putative 0.0044 0.0098 0.0386
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0044 0.0098 0.0386
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0569 0.2419
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Loa Loa (eye worm) oxidoreductase 0.0044 0.0098 0.0409
Plasmodium vivax steroid dehydrogenase, putative 0.0044 0.0098 0.0386
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0386
Echinococcus granulosus synaptic vesicle 2 protein 0.0787 0.2353 0.3696
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0113 0.0474
Leishmania major myo-inositol/proton symporter (MIT) 0.0787 0.2353 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0128 0.045
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0049 0.0113 0.0112
Onchocerca volvulus 0.002 0.0024 0.0074
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0049 0.0113 0.045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0049 0.0113 0.0474
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0474
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0044 0.0098 0.032
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0014 0.0007 0.003
Leishmania major quinonoid dihydropteridine reductase 0.0044 0.0098 0.0386
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0035 0.0141
Brugia malayi Steroid receptor seven-up type 2 0.0049 0.0113 0.0474
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0474
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0069 0.0264
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0044 0.0098 0.0096
Brugia malayi Zinc finger, C2H2 type family protein 0.0078 0.0202 0.0851
Mycobacterium ulcerans hypothetical protein 0.0076 0.0196 0.0704
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.02 0.0571 0.2405
Onchocerca volvulus 0.0052 0.0121 0.0486
Toxoplasma gondii carbonyl reductase 1, putative 0.0044 0.0098 0.0386
Schistosoma mansoni glucose transporter 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0349 0.1476
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.009 0.0238 0.1006
Brugia malayi hypothetical protein 0.002 0.0024 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0007 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0569 0.2419
Brugia malayi Major Facilitator Superfamily protein 0.0787 0.2353 1
Brugia malayi hypothetical protein 0.0232 0.0668 0.2834
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0787 0.2353 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0043 0.0176
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0032 0.0041
Trypanosoma brucei glucose transporter, putative 0.0787 0.2353 1
Onchocerca volvulus 0.0047 0.0108 0.043
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0787 0.2353 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0078 0.0202 0.0829
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.0098 0.0958
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0007 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0176
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0049 0.0113 0.0175
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0196 0.0827
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Plasmodium vivax sugar transporter, putative 0.0787 0.2353 1
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0044 0.0098 0.032
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0041 0.0079
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0032 0.0108
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0041 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.02 0.0571 0.2424
Onchocerca volvulus 0.0787 0.2353 1
Brugia malayi dehydrogenases, short chain protein 9 0.0044 0.0098 0.0409
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0787 0.2353 1
Brugia malayi CXXC zinc finger family protein 0.0052 0.0121 0.0508
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0007 0.003
Mycobacterium ulcerans short-chain type oxidoreductase 0.0044 0.0098 0.0281
Loa Loa (eye worm) sugar transporter 0.0787 0.2353 1
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0388 0.1651
Mycobacterium ulcerans dehydrogenase/reductase 0.0044 0.0098 0.0281
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0044 0.0098 0.032
Loa Loa (eye worm) RNA binding protein 0.0141 0.0391 0.1657
Loa Loa (eye worm) hypothetical protein 0.0171 0.0484 0.2051
Mycobacterium tuberculosis Probable dehydrogenase 0.0044 0.0098 0.032
Leishmania major quinonoid dihydropteridine reductase 0.0044 0.0098 0.0386
Echinococcus multilocularis expressed conserved protein 0.0306 0.0893 0.0891
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0113 0.0175
Mycobacterium tuberculosis Probable oxidoreductase 0.0044 0.0098 0.032
Schistosoma mansoni hypothetical protein 0.0735 0.2193 0.932
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Toxoplasma gondii patched family protein 0.002 0.0024 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Onchocerca volvulus 0.0023 0.0035 0.0117
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.0202 0.0856
Entamoeba histolytica short chain dehydrogenase family protein 0.0044 0.0098 0.0958
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0032 0.0041
Loa Loa (eye worm) hypothetical protein 0.0057 0.0137 0.0578
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0044 0.0098 0.032
Loa Loa (eye worm) steroid hormone receptor 0.0049 0.0113 0.0474
Echinococcus granulosus lamin 0.0026 0.0045 0.0068
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0041 0.0038
Onchocerca volvulus 0.0787 0.2353 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0044 0.0098 0.0281
Loa Loa (eye worm) hypothetical protein 0.0195 0.0556 0.2357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Echinococcus multilocularis ecdysone induced protein 78C 0.0049 0.0113 0.0112
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0041 0.0038
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Brugia malayi Dehydrogenases, short chain protein 30 0.0044 0.0098 0.0409
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Loa Loa (eye worm) sugar transporter 0.0787 0.2353 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0113 0.0112
Echinococcus granulosus solute carrier family 22 0.0787 0.2353 0.3696
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0049 0.0113 0.0112
Schistosoma mansoni intermediate filament proteins 0.0026 0.0045 0.0184
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0068 0.0172 0.0726
Onchocerca volvulus 0.0787 0.2353 1
Trichomonas vaginalis conserved hypothetical protein 0.0787 0.2353 1
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Leishmania major dihydroorotate dehydrogenase 0.02 0.0571 0.2405
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0196 0.0805
Schistosoma mansoni tar DNA-binding protein 0.0141 0.0391 0.1657
Loa Loa (eye worm) transcription factor SMAD2 0.0179 0.0506 0.2147
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0041 0.0079
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0043 0.0065
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0043 0.0041
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0044 0.0098 0.0415
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0137 0.0491
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0035 0.0052
Loa Loa (eye worm) cysteine protease 0.0014 0.0007 0.0024
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.014 0.0388 0.1646
Echinococcus multilocularis FTZ F1 alpha 0.0049 0.0113 0.0112
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0113 0.0474
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Echinococcus granulosus expressed conserved protein 0.0306 0.0893 0.14
Brugia malayi RNA binding protein 0.0141 0.0391 0.1657
Schistosoma mansoni steroid hormone receptor ad4bp 0.0049 0.0113 0.0474
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.0202 0.0856
Brugia malayi Major Facilitator Superfamily protein 0.0787 0.2353 1
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0007 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0032 0.0132
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0049 0.0113 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0032 0.0108
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0569 0.2419
Brugia malayi oxidoreductase 0.0044 0.0098 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0787 0.2353 1
Onchocerca volvulus 0.0044 0.0098 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0114 0.0311 0.1316
Trichomonas vaginalis glucose transporter, putative 0.0787 0.2353 1
Onchocerca volvulus 0.0023 0.0035 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0474
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0078 0.0202 0.2057
Schistosoma mansoni tar DNA-binding protein 0.0141 0.0391 0.1657
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0044 0.0098 0.0958
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0044 0.0098 0.0409
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Echinococcus multilocularis GPCR, family 2 0.009 0.0238 0.0237
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0007 0.003
Mycobacterium tuberculosis Probable oxidoreductase 0.0044 0.0098 0.032
Brugia malayi nuclear receptor RXR 0.0026 0.0043 0.0176
Onchocerca volvulus Protein patched homolog 0.002 0.0024 0.0074
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0113 0.0474
Schistosoma mansoni steroid dehydrogenase 0.0044 0.0098 0.0409
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0041 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0049 0.0113 0.0474
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0069 0.0287
Echinococcus granulosus oxidoreductase 0.0044 0.0098 0.0151
Loa Loa (eye worm) dehydrogenase 0.0044 0.0098 0.0409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0113 0.0474
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0032 0.0108
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.0326 0.0952 0.4044
Brugia malayi hypothetical protein 0.0787 0.2353 1
Echinococcus multilocularis cysteine protease 0.0014 0.0007 0.0006
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0069 0.0287
Entamoeba histolytica hypothetical protein 0.0119 0.0326 0.3369
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0044 0.0098 0.0386
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Onchocerca volvulus 0.0787 0.2353 1
Onchocerca volvulus 0.0022 0.0032 0.0108
Loa Loa (eye worm) oxidoreductase 0.0044 0.0098 0.0409
Brugia malayi steroid hormone receptor 0.0049 0.0113 0.0474
Trichomonas vaginalis glucosylceramidase, putative 0.0138 0.0383 0.1626
Echinococcus granulosus dnaJ subfamily B 0.0735 0.2193 0.3444
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0044 0.0098 0.0386
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0196 0.3032
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0113 0.0474
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.0202 0.0856
Brugia malayi Cathepsin L-like precursor 0.0014 0.0007 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Brugia malayi hypothetical protein 0.0044 0.0098 0.0409
Schistosoma mansoni hypothetical protein 0.009 0.0238 0.1006
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0032 0.0108
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0044 0.0098 0.0958
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0045 0.0184
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0049 0.0113 0.0474
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0044 0.0098 0.0281
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Mycobacterium ulcerans ketoacyl reductase 0.0044 0.0098 0.0281
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0787 0.2353 0.2352
Echinococcus granulosus microtubule associated protein 2 0.0621 0.1849 0.2903
Loa Loa (eye worm) hypothetical protein 0.0076 0.0196 0.0827
Trypanosoma brucei THT1 - hexose transporter, putative 0.0787 0.2353 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0044 0.0098 0.121
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0196 0.0704
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0043 0.0176
Leishmania major hypothetical protein, conserved 0.0044 0.0098 0.0386
Leishmania major cytochrome p450-like protein 0.0025 0.0041 0.0146
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0199 0.0569 0.2415
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0196 0.0704
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0137 0.0452
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0035 0.0033
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0008 0.0026
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0044 0.0098 0.0386
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Echinococcus multilocularis synaptic vesicle 2 protein 0.0787 0.2353 0.2352
Onchocerca volvulus 0.002 0.0024 0.0074
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0003 0.0008
Trypanosoma brucei glucose transporter, putative 0.0787 0.2353 1
Schistosoma mansoni hypothetical protein 0.0135 0.0373 0.1581
Mycobacterium tuberculosis Probable oxidoreductase 0.0044 0.0098 0.032
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Leishmania major hypothetical protein, conserved 0.0044 0.0098 0.0386
Schistosoma mansoni nuclear receptor 0.0023 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.009 0.0238 0.1006
Leishmania major cathepsin L-like protease 0.0053 0.0127 0.051
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0035 0.0033
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0044 0.0098 0.0151
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0474
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0032 0.0041
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0035 0.0141
Schistosoma mansoni steroid dehydrogenase 0.0044 0.0098 0.0409
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0035 0.0141
Echinococcus granulosus Sugar transporter ERD6 protein 0.0787 0.2353 0.3696
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0068 0.0172 0.0268
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0049 0.0113 0.0175
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0043 0.0176
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0787 0.2353 1
Brugia malayi hypothetical protein 0.002 0.0024 0.0098
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Loa Loa (eye worm) oxidoreductase 0.0044 0.0098 0.0409
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0044 0.0098 0.032
Echinococcus multilocularis carbonyl reductase 1 0.0044 0.0098 0.0096
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0787 0.2353 0.2352
Echinococcus granulosus tar DNA binding protein 0.0141 0.0391 0.0612
Echinococcus multilocularis retinol dehydrogenase 13 0.0044 0.0098 0.0096
Brugia malayi hypothetical protein 0.0787 0.2353 1
Brugia malayi TAR-binding protein 0.0141 0.0391 0.1657
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0045 0.0184
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0007 0.0024
Echinococcus granulosus FTZ F1 alpha 0.0049 0.0113 0.0175
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0041 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0113 0.0175
Echinococcus granulosus solute carrier family 22 0.0787 0.2353 0.3696
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0035 0.0052
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0069 0.0264
Schistosoma mansoni hypothetical protein 0.0047 0.0108 0.0453
Trypanosoma brucei short-chain dehydrogenase, putative 0.0044 0.0098 0.0281
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0474
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Brugia malayi CHE-14 protein 0.014 0.0388 0.1646
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0041 0.0038
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0035 0.0117
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0032 0.0108
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0176
Loa Loa (eye worm) fibroinase 0.0014 0.0007 0.0024
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0035 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0013 0.0018
Mycobacterium ulcerans carveol-like dehydrogenase 0.0044 0.0098 0.0281
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0078 0.0202 0.0856
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0386
Echinococcus multilocularis tar DNA binding protein 0.0141 0.0391 0.039
Brugia malayi nuclear receptor RXR 0.0023 0.0035 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0007 0.003
Schistosoma mansoni survival motor neuron protein 0.0047 0.0108 0.0453
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Plasmodium falciparum hexose transporter 0.0787 0.2353 1
Schistosoma mansoni steroid dehydrogenase 0.0044 0.0098 0.0409
Brugia malayi Myosin head containing protein 0.002 0.0024 0.0098
Echinococcus multilocularis carbonyl reductase 1 0.0044 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0032 0.0108
Brugia malayi nuclear hormone receptor 0.0049 0.0113 0.0474
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0032 0.0108
Leishmania major short chain dehydrogenase-like protein 0.0044 0.0098 0.0386
Leishmania major glucose transporter, lmgt3 0.0787 0.2353 1
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0569 0.2419
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0041 0.0038
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0013 0.0003 0.0002
Schistosoma mansoni steroid dehydrogenase 0.0044 0.0098 0.0409
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0044 0.0098 0.0386
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0041 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0049 0.0113 0.0474
Schistosoma mansoni steroid dehydrogenase 0.0044 0.0098 0.0409
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0041 0.0038
Echinococcus granulosus cathepsin l1 0.0014 0.0007 0.0009
Mycobacterium leprae Probable oxidoreductase 0.0044 0.0098 0.121
Brugia malayi hypothetical protein 0.0023 0.0035 0.0141
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0044 0.0098 0.121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Loa Loa (eye worm) ctsf protein 0.0014 0.0007 0.0024
Echinococcus granulosus solute carrier family 22 0.0787 0.2353 0.3696
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0044 0.0098 0.0386
Brugia malayi protein C24B5.3 0.002 0.0024 0.0098
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Mycobacterium ulcerans short-chain dehydrogenase 0.0044 0.0098 0.0281
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0044 0.0098 0.0386
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0044 0.0098 0.0386
Brugia malayi tailless protein 0.0023 0.0035 0.0141
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0041 0.0038
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0041 0.0079
Entamoeba histolytica hypothetical protein 0.0119 0.0326 0.3369
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0032 0.0049
Leishmania major hypothetical protein, conserved 0.0044 0.0098 0.0386
Leishmania major quinonoid dihydropteridine reductase 0.0044 0.0098 0.0386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0044 0.0098 0.0281
Echinococcus granulosus hypothetical protein 0.0044 0.0098 0.0151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0128 0.045
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0361 0.1536
Onchocerca volvulus 0.002 0.0024 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0098 0.0386
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0044 0.0098 0.0415
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0474
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Brugia malayi Niemann-Pick C1 protein precursor 0.0326 0.0952 0.4044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0007 0.003
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0044 0.0098 0.032
Echinococcus multilocularis cathepsin L cysteine protease 0.0014 0.0007 0.0006
Echinococcus multilocularis protein dispatched 1 0.016 0.0448 0.0447
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0361 0.1536
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0044 0.0098 0.0386
Trichomonas vaginalis glucosylceramidase, putative 0.0138 0.0383 0.1626
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0032 0.0132
Echinococcus multilocularis retinol dehydrogenase 11 0.0044 0.0098 0.0096
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0044 0.0098 0.032
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0014 0.0007 0.0024
Onchocerca volvulus 0.0044 0.0098 0.0386
Brugia malayi Sugar transporter family protein 0.0787 0.2353 1
Schistosoma mansoni carbonyl reductase 0.0044 0.0098 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0113 0.0474
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0044 0.0098 0.0151
Echinococcus multilocularis carbonyl reductase 1 0.0044 0.0098 0.0096
Onchocerca volvulus Bile acid receptor homolog 0.0049 0.0113 0.0451
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0014 0.0007 0.0006
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Echinococcus granulosus Solute carrier family 22 5 0.211 0.6365 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0044 0.0098 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0127 0.0406
Schistosoma mansoni steroid dehydrogenase 0.0044 0.0098 0.0409
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0068 0.0172 0.0268
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0044 0.0098 0.0386
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.009 0.0238 0.1006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0035 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0032 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0569 0.2419
Trypanosoma cruzi hexose transporter, putative 0.0787 0.2353 1
Schistosoma mansoni steroid dehydrogenase 0.0044 0.0098 0.0409
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0032 0.0041
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0041 0.0146
Onchocerca volvulus 0.0787 0.2353 1
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0044 0.0098 0.032
Echinococcus multilocularis Niemann Pick C1 protein 0.0465 0.1376 0.1375
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.02 0.0571 0.2405
Toxoplasma gondii sugar transporter ST1 0.0787 0.2353 1
Plasmodium falciparum lipid/sterol:H+ symporter 0.002 0.0024 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0196 0.0805
Onchocerca volvulus 0.0022 0.0032 0.0108
Loa Loa (eye worm) major facilitator superfamily transporter 0.0787 0.2353 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0041 0.0079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0068 0.0172 0.0726
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0041 0.0146
Brugia malayi Cytochrome P450 family protein 0.0142 0.0395 0.1675
Brugia malayi hypothetical protein 0.0023 0.0035 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0014 0.0007 0.003
Giardia lamblia Hexose transporter 0.0787 0.2353 1
Plasmodium vivax hexose transporter 0.0787 0.2353 1
Schistosoma mansoni tar DNA-binding protein 0.0141 0.0391 0.1657
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0044 0.0098 0.0096
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.02 0.0571 0.2322
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0787 0.2353 0.3696
Echinococcus multilocularis steroid dehydrogenase 0.0044 0.0098 0.0096
Toxoplasma gondii hypothetical protein 0.002 0.0024 0.0074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0311 0.12
Echinococcus granulosus Niemann Pick C1 protein 0.0465 0.1376 0.2161
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0098 0.0386
Echinococcus multilocularis solute carrier family 22 0.0787 0.2353 0.2352
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0132
Schistosoma mansoni zinc finger protein 0.0023 0.0035 0.0141
Schistosoma mansoni hypothetical protein 0.0195 0.0556 0.2357
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0003 0.0003
Onchocerca volvulus 0.0044 0.0098 0.0386
Loa Loa (eye worm) oxidoreductase 0.0044 0.0098 0.0409
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0078 0.0202 0.0314
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Mycobacterium ulcerans ketoacyl reductase 0.0044 0.0098 0.0281
Brugia malayi Dehydrogenases, short chain protein 2 0.0044 0.0098 0.0409
Leishmania major glucose transporter/membrane transporter D2, putative 0.0787 0.2353 1
Echinococcus multilocularis lamin 0.0026 0.0045 0.0043
Brugia malayi Latrophilin receptor protein 2 0.009 0.0238 0.1006
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0003 0.0002
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0008 0.0026
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Schistosoma mansoni glucose transport protein 0.0787 0.2353 1
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0078 0.0202 0.0314
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Echinococcus multilocularis carbonyl reductase 1 0.0044 0.0098 0.0096
Onchocerca volvulus 0.0787 0.2353 1
Mycobacterium ulcerans sugar transporter 0.0787 0.2353 1
Trichomonas vaginalis conserved hypothetical protein 0.0787 0.2353 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0041 0.0038
Onchocerca volvulus 0.0787 0.2353 1
Leishmania major short chain dehydrogenase, putative 0.0044 0.0098 0.0386
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0787 0.2353 0.3696
Loa Loa (eye worm) hypothetical protein 0.0787 0.2353 1
Trypanosoma brucei glucose transporter, putative 0.0787 0.2353 1
Onchocerca volvulus 0.002 0.0024 0.0074
Onchocerca volvulus 0.0026 0.0045 0.0161
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.009 0.0238 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0049 0.0113 0.0474
Schistosoma mansoni lamin 0.0026 0.0045 0.0184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0128 0.045
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0035 0.0141
Echinococcus multilocularis lamin dm0 0.0026 0.0045 0.0043
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0199 0.0569 0.2415
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0127 0.051
Echinococcus granulosus carbonyl reductase 1 0.0044 0.0098 0.0151
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0049 0.0113 0.0474
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0032 0.0108
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0032 0.0132
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0098 0.0386
Brugia malayi Patched family protein 0.002 0.0024 0.0098
Onchocerca volvulus 0.0044 0.0098 0.0386
Leishmania major glucose transporter, lmgt2 0.0787 0.2353 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0041 0.0038
Brugia malayi Cathepsin L-like precursor 0.0014 0.0007 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Trichomonas vaginalis sugar transporter, putative 0.0787 0.2353 1
Trypanosoma brucei glucose transporter, putative 0.0787 0.2353 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0044 0.0098 0.0958
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Trypanosoma cruzi hexose transporter 0.0787 0.2353 1
Schistosoma mansoni transcription factor LCR-F1 0.0119 0.0326 0.1378
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0141
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0787 0.2353 0.3696
Loa Loa (eye worm) hypothetical protein 0.0076 0.0196 0.0827
Onchocerca volvulus 0.0076 0.0196 0.0805
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0035 0.0052
Leishmania major pteridine reductase 1 0.0044 0.0098 0.0386
Schistosoma mansoni retinoic acid receptor RXR 0.0049 0.0113 0.0474
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0409
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0787 0.2353 1
Echinococcus granulosus ecdysone induced protein 78C 0.0049 0.0113 0.0175
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Trypanosoma brucei THT1 - hexose transporter, putative 0.0787 0.2353 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Schistosoma mansoni lamin 0.0026 0.0045 0.0184
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0098
Entamoeba histolytica short chain dehydrogenase family protein 0.0044 0.0098 0.0958
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0049 0.0113 0.0474
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0041 0.0079
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0044 0.0098 0.0281
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0044 0.0098 0.032
Brugia malayi Sugar transporter family protein 0.0787 0.2353 1
Schistosoma mansoni short chain dehydrogenase 0.0044 0.0098 0.0409
Echinococcus granulosus mixed lineage leukemia protein mll 0.0013 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0787 0.2353 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0068 0.0172 0.0726
Trypanosoma brucei glucose transporter, putative 0.0787 0.2353 1
Schistosoma mansoni sugar transporter 0.0787 0.2353 1
Echinococcus multilocularis conserved hypothetical protein 0.0044 0.0098 0.0096
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0035 0.0141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0098 0.0409
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0113 0.0112
Schistosoma mansoni steroid dehydrogenase 0.0044 0.0098 0.0409
Mycobacterium ulcerans short chain dehydrogenase 0.0044 0.0098 0.0281
Mycobacterium ulcerans integral membrane transport protein 0.0787 0.2353 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Echinococcus multilocularis Niemann Pick C1 protein 0.0326 0.0952 0.0951
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0032 0.0041
Brugia malayi Patched protein homolog 1 0.002 0.0024 0.0098
Trichomonas vaginalis glucose transporter, putative 0.0787 0.2353 1
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0007 0.0024
Brugia malayi nuclear receptor NHR-88 0.0049 0.0113 0.0474
Echinococcus granulosus carbonyl reductase 1 0.0044 0.0098 0.0151
Leishmania major hypothetical protein, conserved 0.0787 0.2353 1
Echinococcus multilocularis 0.0025 0.0041 0.004
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0044 0.0098 0.0096
Plasmodium falciparum dihydroorotate dehydrogenase 0.02 0.0571 0.2405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Brugia malayi major facilitator superfamily protein 0.0787 0.2353 1
Echinococcus granulosus solute carrier family 22 0.0787 0.2353 0.3696
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0007 0.003
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0044 0.0098 0.0281
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0041 0.0079
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0127 0.051
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0041 0.0079

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 6.7 microL/min/mg Intrinsic clearance in mouse liver microsomes ChEMBL. 21696174
EC50 (functional) = 0.55 uM Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay in presence of human serum ChEMBL. 21696174
IC50 (binding) = 75 nM BindingDB_Patents: Inhibiton Assay. For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002) JBiol Chem., 277, 41827-41834, and Baldwin, et al. (2005) J. Biol. Chem., 280. 21847-21853.Briefly, this colorimetric assay monitors the reduction of 2,6-dichloroindophenol (DCIP) at 600 nm (e = 18.8 mM-1cm-1) for measuring DHOD inhibition. The assay was carried out using a solution containing 100 mM HEPES, pH 8.0, 150 mM NaCl, 10% glycerol, 0.1% Triton X-100, 20 micro molar CoQD (coenzyme QD), 200 micro molar L-dihydroorotate, and 120 micro molar DCIP. Reactions are initiated by addition of enzyme to a final concentration in the range of about 5 nM to about 50 nM while maintaining the temperature of a circulating water bath at 25° C. Alternatively, for potent compounds, activity was determined by directly measuring the production of orotic acid at 296 nm (ε = 4.3 mM-1 cm-1). ChEMBL. No reference
IC50 (binding) = 0.075 uM Inhibition of Plasmodium falciparum C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay ChEMBL. 21696174
IC50 (binding) > 100 uM Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay ChEMBL. 21696174
PPB (ADMET) = 97.7 % Plasma protein binding in human by chromatographic method ChEMBL. 21696174

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 21696174

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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