Detailed information for compound 280386

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 624.729 | Formula: C35H40N6O5
  • H donors: 6 H acceptors: 5 LogP: 3.04 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 3
  • SMILES: Oc1ccc(cc1)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H]([C@@H](c1ccccc1)C)C(=O)N)Cc1c[nH]c2c1cccc2)N
  • InChi: 1S/C35H40N6O5/c1-21(23-8-3-2-4-9-23)31(32(37)43)40-33(44)29(19-24-20-38-28-11-6-5-10-26(24)28)39-34(45)30-12-7-17-41(30)35(46)27(36)18-22-13-15-25(42)16-14-22/h2-6,8-11,13-16,20-21,27,29-31,38,42H,7,12,17-19,36H2,1H3,(H2,37,43)(H,39,45)(H,40,44)/t21-,27+,29+,30+,31+/m1/s1
  • InChiKey: SVSIHTUAQHQOLO-CSKDIXIBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References
Rattus norvegicus Delta opioid receptor Starlite/ChEMBL References
Rattus norvegicus Kappa opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Kappa opioid receptor   380 aa 408 aa 23.5 %
Echinococcus multilocularis neuropeptide receptor Kappa opioid receptor   380 aa 315 aa 26.3 %
Schistosoma mansoni rhodopsin-like orphan GPCR Kappa opioid receptor   380 aa 363 aa 22.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.2 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Onchocerca volvulus Delta opioid receptor   372 aa 386 aa 22.8 %
Onchocerca volvulus Phospholipase d-related homolog Kappa opioid receptor   380 aa 309 aa 19.4 %
Echinococcus granulosus orexin receptor type 2 Kappa opioid receptor   380 aa 381 aa 23.1 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Delta opioid receptor   372 aa 320 aa 25.6 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Schistosoma japonicum Rhodopsin, putative Kappa opioid receptor   380 aa 352 aa 22.2 %
Echinococcus multilocularis allatostatin A receptor Delta opioid receptor   372 aa 302 aa 28.5 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 319 aa 21.9 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Kappa opioid receptor   380 aa 347 aa 22.5 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Kappa opioid receptor   380 aa 352 aa 19.3 %
Echinococcus granulosus neuropeptide receptor Kappa opioid receptor   380 aa 315 aa 26.0 %
Schistosoma mansoni peptide (allatostatin)-like receptor Delta opioid receptor   372 aa 353 aa 29.2 %
Onchocerca volvulus Delta opioid receptor   372 aa 349 aa 22.1 %
Brugia malayi ORL1-like opioid receptor Delta opioid receptor   372 aa 300 aa 24.7 %
Onchocerca volvulus Mitogen-activated protein kinase kinase kinase 8 homolog Kappa opioid receptor   380 aa 384 aa 20.3 %
Onchocerca volvulus Delta opioid receptor   372 aa 316 aa 26.9 %
Brugia malayi GnHR receptor homolog Delta opioid receptor   372 aa 313 aa 18.5 %
Onchocerca volvulus Programmed cell death protein 5 homolog Kappa opioid receptor   380 aa 353 aa 23.2 %
Onchocerca volvulus Kappa opioid receptor   380 aa 313 aa 20.8 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Delta opioid receptor   372 aa 366 aa 22.7 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Delta opioid receptor   372 aa 315 aa 28.6 %
Onchocerca volvulus Kappa opioid receptor   380 aa 344 aa 24.4 %
Onchocerca volvulus Phosphoinositide 3-kinase adapter subunit homolog Kappa opioid receptor   380 aa 332 aa 23.5 %
Echinococcus granulosus allatostatin A receptor Delta opioid receptor   372 aa 302 aa 27.8 %
Loa Loa (eye worm) neuropeptide F receptor Delta opioid receptor   372 aa 317 aa 23.3 %
Echinococcus multilocularis orexin receptor type 2 Kappa opioid receptor   380 aa 381 aa 22.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.5 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Kappa opioid receptor   380 aa 310 aa 20.0 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Kappa opioid receptor   380 aa 337 aa 25.8 %
Onchocerca volvulus Delta opioid receptor   372 aa 353 aa 21.0 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 332 aa 20.5 %
Onchocerca volvulus Delta opioid receptor   372 aa 344 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0085
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0026 0.0051
Echinococcus multilocularis neuropeptides capa receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.0098
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Loa Loa (eye worm) RNA binding protein 0.0135 0.0304 0.1025
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.0104 0.0208
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0165 0.0379 0.1282
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0104 0.0349
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0086 0.0329
Brugia malayi GnHR receptor homolog 0.0084 0.0173 0.0664
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0054 0.0051
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0107 0.0232 0.0783
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0026 0.0097
Schistosoma mansoni hypothetical protein 0.1237 0.3112 0.8498
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0084 0.0173 0.0347
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0023 0.002 0.0016
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0232 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0137 0.0534
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0005 0.0019
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0143 0.0324 0.1247
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0005 0.0002
Plasmodium vivax phosphodiesterase gamma, putative 0.0143 0.0324 0.2735
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0025 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.1026 0.2574 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Brugia malayi Tachykinin-like peptides receptor 99D 0.0084 0.0173 0.0664
Echinococcus granulosus neuropeptides capa receptor 0.0084 0.0173 0.0347
Trichomonas vaginalis dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0479 0.118 0.454
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0104 0.1945
Echinococcus granulosus allatostatin A receptor 0.0084 0.0173 0.0347
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0072 0.0144 0.0483
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0179
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0117 0.0455
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0035 0.0135
Schistosoma mansoni nAChR subunit 0.0165 0.0381 0.1036
Brugia malayi Dopamine receptor protein 1 0.0084 0.0173 0.0664
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0084 0.0173 0.0347
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0009 0.0009
Brugia malayi hypothetical protein 0.0084 0.0173 0.0664
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0086 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0046 0.0179
Echinococcus granulosus importin subunit beta 1 0.0029 0.0035 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0026 0.0097
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0358 0.0872 0.1759
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0324 0.1253
Leishmania major p-glycoprotein e 0.0028 0.003 0.0113
Brugia malayi hypothetical protein 0.0084 0.0173 0.0664
Onchocerca volvulus 0.0084 0.0173 0.1366
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0005 0.0004
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Mycobacterium tuberculosis Probable oxidoreductase 0.0027 0.0028 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0304 0.0825
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0143 0.0324 0.1187
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0091
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0115 0.0229
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0084 0.0173 0.0469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0173 0.0469
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0084 0.0173 0.0582
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0079 0.0262
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.0137 0.0528
Toxoplasma gondii ABC1 family protein 0.0107 0.0232 0.0783
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0056 0.0209
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0115 0.044
Loa Loa (eye worm) hypothetical protein 0.0193 0.0451 0.1526
Mycobacterium ulcerans polyketide synthase Pks13 0.0036 0.0052 0.0051
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0056 0.0211
Plasmodium falciparum phosphodiesterase delta, putative 0.0143 0.0324 0.2735
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0232 0.023
Echinococcus granulosus g protein coupled receptor 0.0084 0.0173 0.0347
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0026 0.0051
Brugia malayi PHD-finger family protein 0.0029 0.0034 0.0127
Loa Loa (eye worm) G-protein coupled receptor 0.0084 0.0173 0.0582
Schistosoma mansoni biogenic amine receptor 0.0084 0.0173 0.0469
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0021 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0358 0.0872 0.3369
Schistosoma mansoni hypothetical protein 0.0025 0.0024 0.0061
Schistosoma mansoni tyrosine kinase 0.0295 0.0712 0.1942
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0084 0.0173 0.0469
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0143 0.0324 0.0651
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0026 0.0051
Brugia malayi glutathione reductase 0.0044 0.0073 0.0276
Schistosoma mansoni opsin-like receptor 0.0084 0.0173 0.0469
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0358 0.0872 0.1759
Entamoeba histolytica hypothetical protein 0.0076 0.0154 0.3087
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0026 0.0068
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0004 0.0006
Brugia malayi AMP-binding enzyme family protein 0.005 0.0086 0.0328
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0026 0.0051
Loa Loa (eye worm) hypothetical protein 0.0193 0.0451 0.1526
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0358 0.0872 0.1759
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0084 0.0173 0.0469
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0115 0.0229
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0084 0.0173 0.0347
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0027 0.0026
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0344 0.0838 0.2837
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0017 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0137 0.0534
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0037 0.0055 0.0051
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.001
Loa Loa (eye worm) TYRA-2 protein 0.0084 0.0173 0.0582
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1258
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0021 0.0018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0025 0.0025
Echinococcus multilocularis neuropeptide receptor A26 0.0084 0.0173 0.0347
Mycobacterium ulcerans oxidoreductase 0.0027 0.0028 0.0028
Trypanosoma cruzi actin interacting protein-like protein, putative 0.0027 0.0028 0.0104
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Mycobacterium tuberculosis Possible oxidoreductase 0.0027 0.0028 0.0025
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0358 0.0872 0.3369
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0084 0.0173 0.0469
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0116 0.0231
Leishmania major ABC-thiol transporter 0.0028 0.003 0.0113
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0143 0.0324 0.0651
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.1026 0.2574 1
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0102 0.0398
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Echinococcus granulosus somatostatin receptor 0.0084 0.0173 0.0347
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0059 0.0889
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0027 0.0085
Mycobacterium ulcerans thioesterase 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0113
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.003 0.0226
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0009 0.0009
Loa Loa (eye worm) TK/EGFR protein kinase 0.0924 0.2315 0.7847
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1173 0.2949 0.5956
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0116 0.0231
Onchocerca volvulus 0.0084 0.0173 0.1366
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1258
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0165 0.0381 0.1468
Echinococcus multilocularis neuropeptides capa receptor 0.0084 0.0173 0.0347
Mycobacterium tuberculosis Probable reductase 0.0101 0.0217 0.0214
Mycobacterium ulcerans lipase LipD 0.0107 0.0232 0.0232
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.1026 0.2574 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0025 0.0025
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni tyrosine kinase 0.0497 0.1225 0.3343
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0358 0.0872 0.1759
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0193 0.0451 0.1229
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.103 0.2585 0.8766
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0358 0.0872 0.1759
Brugia malayi cell division control protein 2 homolog 0.0052 0.0092 0.0351
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0143 0.0324 0.0651
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0358 0.0872 0.1759
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0026 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0049 0.0046
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0005 0.0004
Loa Loa (eye worm) PDE1B protein 0.0143 0.0324 0.1093
Trypanosoma brucei L-galactonolactone oxidase 0.0027 0.0028 0.011
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0005 0.0002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0056 0.0148
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0023 0.002 0.0016
Echinococcus granulosus g-protein coupled receptor 0.0084 0.0173 0.0347
Brugia malayi nuclear hormone receptor 0.0026 0.0026 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0026 0.0097
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0497 0.1225 0.2472
Mycobacterium ulcerans DNA polymerase IV 0.007 0.0137 0.0137
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0026 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0173 0.0469
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.0092 0.0183
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0143 0.0324 0.1247
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0005 0.0002
Brugia malayi Cytochrome P450 family protein 0.0026 0.0027 0.0098
Mycobacterium leprae PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE) 0.393 0.9975 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.0246 0.0243
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0143 0.0324 0.1253
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.0092 0.0308
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0232 0.023
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0004 0.0008
Echinococcus multilocularis geminin 0.1237 0.3112 0.6285
Echinococcus multilocularis sex peptide receptor 0.0084 0.0173 0.0347
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0143 0.0324 0.1253
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0092 0.028
Schistosoma mansoni hypothetical protein 0.0017 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.008 0.0267
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0026 0.0068
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0115 0.0309
Mycobacterium tuberculosis Conserved protein 0.0107 0.0232 0.023
Mycobacterium ulcerans UDP-N-acetylenolpyruvoylglucosamine reductase 0.393 0.9975 0.9975
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0165 0.0381 0.1468
Brugia malayi Protein kinase domain containing protein 0.0052 0.0092 0.0351
Trypanosoma brucei hypothetical protein, conserved 0.0143 0.0324 0.1258
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0104 0.0255
Brugia malayi G-protein coupled receptor 0.0084 0.0173 0.0664
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni neuropeptide receptor 0.0084 0.0173 0.0469
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0358 0.0872 0.3369
Mycobacterium leprae Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD 0.2497 0.6322 0.6338
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0143 0.0324 0.1258
Entamoeba histolytica multidrug resistance protein, putative 0.0028 0.003 0.0226
Echinococcus multilocularis multidrug resistance associated protein 4 0.0021 0.0014 0.0026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0026 0.0085
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.0217 0.0214
Schistosoma mansoni neuropeptide receptor 0.0084 0.0173 0.0469
Schistosoma mansoni neuropeptide F-like receptor 0.0084 0.0173 0.0469
Brugia malayi Amyloid A4 extracellular domain containing protein 0.1003 0.2515 0.9729
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0232 0.0902
Echinococcus multilocularis fmrfamide receptor 0.0084 0.0173 0.0347
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0017 0.0003 0.0003
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0004 0.0006
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0143 0.0324 0.1247
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0026 0.0097
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0104 0.1945
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0021 0.0021
Echinococcus multilocularis zinc finger protein 0.0024 0.002 0.0038
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1173 0.2949 0.5956
Loa Loa (eye worm) beta-lactamase 0.0107 0.0232 0.0783
Echinococcus granulosus epidermal growth factor receptor 0.0497 0.1225 0.2472
Schistosoma mansoni hypothetical protein 0.0084 0.0173 0.0469
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0143 0.0324 0.1093
Echinococcus multilocularis glycine receptor subunit beta 0.0358 0.0872 0.1759
Schistosoma mansoni neurotransmitter gated ion channel 0.0165 0.0381 0.1036
Giardia lamblia DINP protein human, muc B family 0.0045 0.0076 0.0158
Onchocerca volvulus 0.0358 0.0872 0.7359
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0079 0.0156
Echinococcus multilocularis nAChR subunit 0.0358 0.0872 0.1759
Leishmania major D-lactate dehydrogenase-like protein 0.0027 0.0028 0.0104
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0092 0.0183
Onchocerca volvulus 0.0358 0.0872 0.7359
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0056 0.0809
Mycobacterium leprae ProbableUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.1764 0.4456 0.4467
Schistosoma mansoni neuropeptide receptor 0.0084 0.0173 0.0469
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0084 0.0173 0.0469
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Mycobacterium tuberculosis Possible flavoprotein 0.0027 0.0028 0.0025
Brugia malayi beta-lactamase family protein 0.0107 0.0232 0.0893
Mycobacterium ulcerans UDP-N-acetylmuramyl tripeptide synthase 0.0479 0.118 0.118
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramoylalanine-D-glutamate ligase 0.2976 0.7542 0.7547
Brugia malayi beta-lactamase family protein 0.0107 0.0232 0.0893
Schistosoma mansoni survival motor neuron protein 0.0049 0.0085 0.0229
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.0217 0.0217
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.0137 0.0528
Schistosoma mansoni amine GPCR 0.0084 0.0173 0.0469
Mycobacterium leprae Probable UDP-N-acetylmuramate-alanine ligase MurC 0.0753 0.1878 0.1882
Loa Loa (eye worm) hypothetical protein 0.0107 0.0232 0.0783
Echinococcus multilocularis allatostatin A receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0165 0.0379 0.1282
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Mycobacterium ulcerans UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase 0.1764 0.4456 0.4455
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.1026 0.2574 1
Brugia malayi MAP kinase sur-1 0.1026 0.2574 0.9957
Leishmania major importin beta-1 subunit, putative 0.0024 0.0021 0.0075
Echinococcus granulosus neuropeptide Y receptor 0.0084 0.0173 0.0347
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Onchocerca volvulus 0.0084 0.0173 0.1366
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Brugia malayi Furin-like cysteine rich region family protein 0.0924 0.2315 0.8952
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramate-alanine ligase 0.2517 0.6373 0.6368
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0084 0.0173 0.0582
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.1026 0.2574 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Brugia malayi Thioredoxin reductase 0.0044 0.0073 0.0276
Echinococcus granulosus zinc finger protein 0.0024 0.002 0.0038
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0036 0.0052 0.0049
Trypanosoma cruzi hypothetical protein 0.0021 0.0014 0.0049
Brugia malayi AKH receptor 0.0084 0.0173 0.0664
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0005 0.0004
Echinococcus granulosus neuropeptide receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0014 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Echinococcus granulosus g protein coupled receptor 0.0084 0.0173 0.0347
Schistosoma mansoni hypothetical protein 0.0084 0.0173 0.0469
Trichomonas vaginalis CMGC family protein kinase 0.1026 0.2574 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1173 0.2949 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0005 0.0004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0232 0.0893
Onchocerca volvulus 0.0358 0.0872 0.7359
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0019 0.0035
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0065 0.0119
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Loa Loa (eye worm) hypothetical protein 0.0193 0.0451 0.1526
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0143 0.0324 0.0651
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0143 0.0324 0.1253
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.1026 0.2574 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.0246 0.0243
Mycobacterium tuberculosis L-gulono-1,4-lactone dehydrogenase 0.0027 0.0028 0.0025
Plasmodium vivax glutathione reductase, putative 0.0044 0.0073 0.0604
Leishmania major hypothetical protein, conserved 0.0143 0.0324 0.1253
Schistosoma mansoni amine GPCR 0.0084 0.0173 0.0469
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0004 0.0008
Echinococcus multilocularis microtubule associated protein 2 0.1453 0.3662 0.7396
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0085
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Echinococcus multilocularis GPCR, family 2 0.0017 0.0004 0.0006
Brugia malayi beta-lactamase 0.0107 0.0232 0.0893
Onchocerca volvulus Huntingtin homolog 0.0125 0.0278 0.227
Echinococcus multilocularis somatostatin receptor 0.0084 0.0173 0.0347
Brugia malayi follicle stimulating hormone receptor 0.0344 0.0838 0.3236
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0084 0.0173 0.0347
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1959 0.4951 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Echinococcus granulosus dna polymerase kappa 0.007 0.0137 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0026 0.0085
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0143 0.0324 0.1187
Onchocerca volvulus 0.0358 0.0872 0.7359
Trypanosoma brucei alkyl-dihydroxyacetone phosphate synthase 0.0027 0.0028 0.011
Entamoeba histolytica protein kinase, putative 0.0057 0.0104 0.1945
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0232 0.0897
Schistosoma mansoni hypothetical protein 0.0314 0.076 0.2073
Echinococcus granulosus mitogen activated protein kinase 0.1026 0.2574 0.5199
Trypanosoma brucei trypanothione reductase 0.0044 0.0073 0.0282
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0084 0.0173 0.0347
Loa Loa (eye worm) GABA receptor subunit 0.0193 0.0451 0.1526
Onchocerca volvulus 0.0084 0.0173 0.1366
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0165 0.0381 0.1468
Mycobacterium leprae Polyketide synthase Pks13 0.0036 0.0052 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0173 0.0469
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0084 0.0173 0.0469
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0143 0.0324 0.1258
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0059 0.0223
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0366 0.0892 0.2432
Schistosoma mansoni ap endonuclease 0.0039 0.0059 0.0157
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0232 0.023
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0028 0.003 0.0113
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0073 0.0277
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.0028 0.003 0.0226
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0084 0.0173 0.0347
Chlamydia trachomatis bifunctional UDP-N-acetylmuramate-alanine ligase/D-alanine-D-alanine ligase 0.2517 0.6373 0.6354
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.2735
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0086 0.0083
Echinococcus multilocularis snurportin 1 0.0314 0.076 0.1533
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0154 0.0308
Loa Loa (eye worm) hypothetical protein 0.0039 0.006 0.0198
Echinococcus multilocularis g-protein coupled receptor 0.0084 0.0173 0.0347
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0004 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0137 0.0534
Mycobacterium tuberculosis Probable oxidoreductase 0.0027 0.0028 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.0337 0.0679
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.003 0.0099
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0085
Mycobacterium ulcerans oxidoreductase 0.0027 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Echinococcus granulosus folylpolyglutamate synthase mitochondrial 0.0479 0.118 0.2382
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0102 0.0857
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.1173 0.2949 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0165 0.0381 0.1468
Trypanosoma brucei multidrug resistance protein E 0.0028 0.003 0.0118
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0059 0.0195
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Schistosoma mansoni DNA polymerase eta 0.0038 0.0056 0.0148
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0232 0.0828
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0121 0.0241
Brugia malayi putative neuropeptide receptor NPR1 0.0084 0.0173 0.0664
Echinococcus granulosus cyclin dependent kinase 0.0052 0.0092 0.0183
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0143 0.0324 0.0651
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.0092 0.0183
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0479 0.118 0.2382
Brugia malayi steroid hormone receptor 0.0026 0.0026 0.0097
Brugia malayi jmjC domain containing protein 0.0063 0.0121 0.0461
Mycobacterium leprae Probable oxidoreductase 0.0027 0.0028 0.0028
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0059 0.0058
Brugia malayi jmjC domain containing protein 0.0061 0.0116 0.0442
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0028 0.003 0.0098
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0358 0.0872 0.1759
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0077 0.0291
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0073 0.007
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0143 0.0324 0.0651
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Schistosoma mansoni neuropeptide receptor 0.0084 0.0173 0.0469
Brugia malayi Serotonin receptor 0.0084 0.0173 0.0664
Trichomonas vaginalis CMGC family protein kinase 0.1026 0.2574 1
Echinococcus granulosus FAD binding protein type 2 0.0027 0.0028 0.0054
Loa Loa (eye worm) hypothetical protein 0.0107 0.0232 0.0783
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0358 0.0872 0.2379
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1173 0.2949 0.5956
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0287
Loa Loa (eye worm) acetyltransferase 0.0155 0.0354 0.1197
Brugia malayi G protein-coupled receptor F59B2.13 0.0084 0.0173 0.0664
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0102 0.0392
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0304 0.0825
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0102 0.0857
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0005 0.0002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0055 0.018
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0005 0.0004
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0054 0.0448
Loa Loa (eye worm) hypothetical protein 0.079 0.1974 0.669
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0005 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0005 0.0002
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.0092 0.0183
Brugia malayi RE15519p 0.0084 0.0173 0.0664
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0005 0.0002
Schistosoma mansoni zinc finger protein 0.0024 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0005 0.0002
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0028 0.003 0.0113
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0005 0.0004
Leishmania major cytochrome p450-like protein 0.0026 0.0027 0.0098
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.1026 0.2574 0.8728
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0165 0.0381 0.0766
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0304 0.0825
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0026 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0026 0.0097
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Echinococcus granulosus dro:myosuppressin receptor 0.0084 0.0173 0.0347
Mycobacterium ulcerans folylpolyglutamate synthase protein FolC 0.1443 0.3638 0.3638
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0004 0.0006
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0046 0.0179
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0026 0.0109
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0358 0.0872 0.3369
Brugia malayi hypothetical protein 0.0036 0.0052 0.0195
Plasmodium falciparum thioredoxin reductase 0.0044 0.0073 0.0604
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0046 0.0179
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Echinococcus multilocularis orexin receptor type 2 0.0084 0.0173 0.0347
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0026 0.0051
Treponema pallidum UDP-N-acetylmuramate--L-alanine ligase 0.2517 0.6373 0.6352
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Onchocerca volvulus 0.0084 0.0173 0.1366
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0125 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0304 0.0825
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0027 0.0028 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0079 0.0211
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0086 0.0083
Echinococcus granulosus tm gpcr rhodopsin 0.0084 0.0173 0.0347
Schistosoma mansoni nAChR subunit 0.0358 0.0872 0.2379
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Brugia malayi hypothetical protein 0.0165 0.0381 0.1468
Onchocerca volvulus 0.0084 0.0173 0.1366
Echinococcus granulosus glycine receptor subunit alpha 1 0.0358 0.0872 0.1759
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0232 0.0232
Loa Loa (eye worm) acetylcholine receptor protein 0.0165 0.0381 0.1287
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0054 0.0448
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0026 0.0051
Brugia malayi intracellular kinase 0.0057 0.0104 0.0399
Schistosoma mansoni nAChR subunit 0.0165 0.0381 0.1036
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0026 0.0085
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.008 0.0669
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0092 0.028
Trypanosoma brucei protein kinase, putative 0.0057 0.0104 0.0406
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.001
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0028 0.003 0.0113
Mycobacterium ulcerans polyketide synthase 0.0024 0.0021 0.0021
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0143 0.0324 0.0881
Mycobacterium tuberculosis Decaprenylphosphoryl-beta-D-ribose 2'-oxidase 0.0027 0.0028 0.0025
Onchocerca volvulus 0.0107 0.0232 0.1873
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0084 0.0173 0.0664
Schistosoma mansoni growth hormone secretagogue receptor 0.0084 0.0173 0.0469
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0004 0.0011
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.0092 0.0353
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0004 0.0006
Mycobacterium ulcerans oxidoreductase 0.0027 0.0028 0.0028
Echinococcus multilocularis G protein coupled receptor 139 0.0084 0.0173 0.0347
Onchocerca volvulus 0.0037 0.0055 0.035
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0056 0.0148
Echinococcus granulosus neuropeptide receptor 0.0084 0.0173 0.0347
Mycobacterium tuberculosis Probable oxidoreductase 0.0027 0.0028 0.0025
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0005 0.0013
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.1026 0.2574 0.8728
Loa Loa (eye worm) TK/INSR protein kinase 0.0295 0.0712 0.2412
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0358 0.0872 0.3369
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0084 0.0173 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0026 0.0085
Onchocerca volvulus 0.0057 0.0104 0.0776
Schistosoma mansoni tyrosine kinase 0.0497 0.1225 0.3343
Brugia malayi nuclear receptor NHR-88 0.0026 0.0026 0.0097
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Echinococcus multilocularis insulin receptor 0.0295 0.0712 0.1436
Plasmodium falciparum protein kinase 5 0.0052 0.0092 0.077
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0004 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0079 0.0156
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0143 0.0324 0.1253
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0084 0.0173 0.0469
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0005 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0324 0.1253
Schistosoma mansoni adenoreceptor 0.0084 0.0173 0.0469
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0021 0.0075
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Schistosoma mansoni cytochrome P450 0.0018 0.0005 0.0009
Giardia lamblia Multidrug resistance-associated protein 1 0.0028 0.003 0.0002
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0358 0.0872 0.2379
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0085 0.0325
Schistosoma mansoni ap endonuclease 0.0039 0.0059 0.0157
Mycobacterium ulcerans hypothetical protein 0.005 0.0086 0.0085
Onchocerca volvulus 0.0107 0.0232 0.1873
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0017 0.0004 0.0001
Onchocerca volvulus 0.0165 0.0381 0.3146
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0084 0.0173 0.0347
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.0104 0.0874
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.0354 0.1366
Loa Loa (eye worm) hypothetical protein 0.0193 0.0451 0.1526
Onchocerca volvulus 0.0084 0.0173 0.1366
Loa Loa (eye worm) hypothetical protein 0.0143 0.0324 0.1093
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0027 0.0085
Toxoplasma gondii thioredoxin reductase 0.0044 0.0073 0.0242
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.1026 0.2574 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0026 0.0097
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramyl tripeptide synthase 0.1443 0.3638 0.3609
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0073 0.0604
Echinococcus granulosus nAChR subunit 0.0193 0.0451 0.0909
Brugia malayi hypothetical protein 0.0165 0.0381 0.1468
Echinococcus granulosus insulin receptor 0.0295 0.0712 0.1436
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0026 0.0051
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0005 0.0004
Onchocerca volvulus 0.0358 0.0872 0.7359
Leishmania major L-gulonolactone oxidase, putative 0.0027 0.0028 0.0104
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0005 0.0002
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0143 0.0324 0.0651
Schistosoma mansoni hypothetical protein 0.0017 0.0004 0.0008
Mycobacterium ulcerans thioesterase TesA 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0193 0.0451 0.1526
Leishmania major DNA polymerase kappa, putative 0.0045 0.0076 0.0289
Brugia malayi hypothetical protein 0.0084 0.0173 0.0664
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0085
Giardia lamblia Kinase, CMGC MAPK 0.1026 0.2574 0.8715
Leishmania major cAMP-specific phosphodiesterase, putative 0.0143 0.0324 0.1253
Mycobacterium ulcerans oxidoreductase 0.0027 0.0028 0.0028
Schistosoma mansoni tyrosine kinase 0.0491 0.1212 0.3306
Brugia malayi hypothetical protein 0.0084 0.0173 0.0664
Toxoplasma gondii exonuclease III APE 0.0039 0.0059 0.0195
Schistosoma mansoni biogenic amine (5HT) receptor 0.0084 0.0173 0.0469
Entamoeba histolytica hypothetical protein 0.0076 0.0154 0.3087
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Mycobacterium ulcerans UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 0.394 1 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0021 0.0021
Schistosoma mansoni microtubule-associated protein tau 0.1453 0.3662 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0015 0.0047
Schistosoma mansoni hypothetical protein 0.0076 0.0154 0.0416
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0358 0.0872 0.3369
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0028 0.0028
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0232 0.023
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.0217 0.0214
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0358 0.0872 0.1759
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0071 0.0491
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0035 0.0135
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0025 0.0022
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0026 0.0068
Schistosoma mansoni nAChR subunit 0.0358 0.0872 0.2379
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0193 0.0451 0.1229
Echinococcus multilocularis mitogen activated protein kinase 0.1026 0.2574 0.5199
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0005 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.1026 0.2574 0.7029
Onchocerca volvulus 0.005 0.0086 0.0621
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0137 0.0534
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0143 0.0324 0.1253
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0059 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0049 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0026 0.0068
Echinococcus multilocularis FAD binding protein, type 2 0.0027 0.0028 0.0054
Echinococcus multilocularis neuropeptide Y receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Brugia malayi RNA binding protein 0.0135 0.0304 0.1169
Echinococcus granulosus tar DNA binding protein 0.0135 0.0304 0.061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.008 0.0233
Mycobacterium tuberculosis Probable dehydrogenase 0.0027 0.0028 0.0025
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0004 0.0008
Brugia malayi Cytochrome P450 family protein 0.0037 0.0054 0.0204
Onchocerca volvulus Neuropeptide F receptor homolog 0.0084 0.0173 0.1366
Loa Loa (eye worm) G-protein coupled receptor 0.0084 0.0173 0.0582
Loa Loa (eye worm) hypothetical protein 0.0212 0.05 0.1692
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Mycobacterium tuberculosis Possible oxidoreductase 0.0027 0.0028 0.0025
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0028 0.003 0.0118
Toxoplasma gondii bifunctional protein FolC subfamily protein 0.0479 0.118 0.3999
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0324 0.1187
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0085
Loa Loa (eye worm) hypothetical protein 0.0045 0.0075 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0071 0.0277
Schistosoma mansoni nAChR subunit 0.0358 0.0872 0.2379
Schistosoma mansoni tyrosine kinase 0.0491 0.1212 0.3306
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0084 0.0173 0.0664
Loa Loa (eye worm) hypothetical protein 0.0193 0.0451 0.1526
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0173 0.0469
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0092 0.0214
Mycobacterium tuberculosis Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD 0.2497 0.6322 0.6337
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0021 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0232 0.063
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0084 0.0173 0.0347
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0358 0.0872 0.3369
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0076 0.0289
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0143 0.0324 0.1247
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.007 0.0137 0.0457
Brugia malayi RNA, U transporter 1 0.0084 0.0173 0.0664
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.0098
Echinococcus multilocularis neuropeptide receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) neuropeptide F receptor 0.0084 0.0173 0.0582
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0059 0.0224
Echinococcus multilocularis protein kinase shaggy 0.0057 0.0104 0.0208
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Trichomonas vaginalis CMGC family protein kinase 0.1026 0.2574 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0358 0.0872 0.2954
Brugia malayi Importin beta-1 subunit 0.0029 0.0035 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0137 0.0534
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0005 0.0002
Brugia malayi hypothetical protein 0.0158 0.0362 0.1394
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0086 0.1519
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Plasmodium falciparum glutathione reductase 0.0044 0.0073 0.0604
Echinococcus granulosus fmrfamide receptor 0.0084 0.0173 0.0347
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0143 0.0324 0.1247
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0026 0.0051
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0154 0.0416
Plasmodium vivax importin-beta 2, putative 0.0029 0.0035 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0143 0.0324 0.1093
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.008 0.0267
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0143 0.0324 0.0881
Entamoeba histolytica ABC transporter, putative 0.0028 0.003 0.0226
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.076 0.2575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0026 0.0085
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0092 0.0353
Schistosoma mansoni multidrug resistance protein 0.0028 0.003 0.0079
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0092 0.1661
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramyl pentapeptide synthase 0.1764 0.4456 0.4434
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0104 0.0349
Leishmania major alkyldihydroxyacetonephosphate synthase 0.0027 0.0028 0.0104
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0054 0.0054
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0084 0.0173 0.0582
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.0104 0.0281
Schistosoma mansoni biogenic amine receptor 0.0084 0.0173 0.0469
Mycobacterium leprae possible ligase 0.0479 0.118 0.1183
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0304 0.0825
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0425 0.1042 0.3529
Trypanosoma cruzi alkyl-dihydroxyacetone phosphate synthase, putative 0.0027 0.0028 0.0104
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0358 0.0872 0.3369
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0084 0.0173 0.0469
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0115 0.0114
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0232 0.0466
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0005 0.0004
Loa Loa (eye worm) ACC-1 protein 0.0358 0.0872 0.2954
Brugia malayi AMP-binding enzyme family protein 0.005 0.0086 0.0328
Loa Loa (eye worm) cytochrome P450 0.0018 0.0005 0.0012
Leishmania major hypothetical protein, conserved 0.0107 0.0232 0.0897
Brugia malayi TAR-binding protein 0.0135 0.0304 0.1169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Brugia malayi Protein kinase domain containing protein 0.0295 0.0712 0.2751
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0121 0.0326
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0004 0.0006
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0056 0.0216
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0005 0.0004
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0025 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0079 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0137 0.0534
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.0104 0.04
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.0092 0.0183
Loa Loa (eye worm) glutathione reductase 0.0044 0.0073 0.0242
Echinococcus multilocularis neuropeptide FF receptor 2 0.0084 0.0173 0.0347
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0092 0.1661
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0026 0.0051
Trypanosoma brucei DNA polymerase IV, putative 0.007 0.0137 0.0534
Onchocerca volvulus 0.0084 0.0173 0.1366
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0026 0.0097
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0092 0.0308
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0056 0.021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Brugia malayi hypothetical protein 0.0165 0.0381 0.1468
Loa Loa (eye worm) hypothetical protein 0.0125 0.0278 0.094
Brugia malayi ORL1-like opioid receptor 0.0084 0.0173 0.0664
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0143 0.0324 0.0881
Echinococcus granulosus 7tm_1 domain containing protein 0.0084 0.0173 0.0347
Brugia malayi hypothetical protein 0.0125 0.0278 0.1072
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0185
Schistosoma mansoni myosin xvIII 0.0084 0.0173 0.0469
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0059 0.0224
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0358 0.0872 0.1759
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.0354 0.0964
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0358 0.0872 0.2954
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0137 0.0534
Echinococcus granulosus GPCR family 2 0.0017 0.0004 0.0006
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0035 0.0113
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0232 0.0828
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0021 0.0078
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0009
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0005 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0005 0.0002
Brugia malayi hypothetical protein 0.0241 0.0575 0.2219
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Onchocerca volvulus 0.0084 0.0173 0.1366
Onchocerca volvulus 0.0026 0.0026 0.0109
Echinococcus granulosus geminin 0.1237 0.3112 0.6285
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni hypothetical protein 0.0021 0.0014 0.0033
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.0092 0.0358
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0054 0.0179
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0074 0.0147
Trichomonas vaginalis DNA polymerase eta, putative 0.007 0.0137 0.0457
Brugia malayi Cytochrome P450 family protein 0.0026 0.0027 0.0098
Loa Loa (eye worm) TAR-binding protein 0.0135 0.0304 0.1025
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0027 0.0085
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.103 0.2585 1
Schistosoma mansoni tyrosine kinase 0.0295 0.0712 0.1942
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0102 0.0857
Echinococcus multilocularis multidrug resistance associated protein 1 0.0028 0.003 0.0059
Schistosoma mansoni biogenic amine (5HT) receptor 0.0084 0.0173 0.0469
Loa Loa (eye worm) hypothetical protein 0.0193 0.0451 0.1526
Treponema pallidum UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD) 0.394 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0084 0.0173 0.0469
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0005 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.0246 0.0243
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0358 0.0872 0.2954
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0059 0.0116
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0287
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0084 0.0173 0.0347
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0027 0.0098
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0295 0.0712 0.1436
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0011 0.0011
Mycobacterium ulcerans beta-lactamase 0.0107 0.0232 0.0232
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0005 0.0002
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0165 0.0381 0.0766
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Brugia malayi Bromodomain containing protein 0.0043 0.0069 0.0262
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0358 0.0872 0.2379
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0059 0.0224
Leishmania major hypothetical protein, conserved 0.0056 0.0102 0.0392
Trypanosoma brucei unspecified product 0.0026 0.0026 0.01
Echinococcus granulosus neuropeptide Y receptor 0.0084 0.0173 0.0347
Brugia malayi hypothetical protein 0.0084 0.0173 0.0664
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.0092 0.0358
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0059 0.0488
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0092 0.0308
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.0217 0.0214
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0021 0.0018
Leishmania major hypothetical protein, conserved 0.0143 0.0324 0.1253
Giardia lamblia Hypothetical protein 0.0143 0.0324 0.1007
Mycobacterium ulcerans dehydrogenase 0.0027 0.0028 0.0028
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0074 0.0147
Loa Loa (eye worm) alkyldihydroxyacetonephosphate synthase 0.0027 0.0028 0.0091
Schistosoma mansoni bromodomain containing protein 0.0068 0.0134 0.0362
Schistosoma mansoni importin beta-1 0.0029 0.0035 0.0091
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Echinococcus multilocularis serotonin receptor 0.0084 0.0173 0.0347
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0092 0.0353
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0073 0.0242
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.0104 0.0208
Echinococcus granulosus epidermal growth factor receptor 0.0924 0.2315 0.4674
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0026 0.0051
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0179
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0143 0.0324 0.0881
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0026 0.0097
Brugia malayi Melatonin receptor type 1A 0.0084 0.0173 0.0664
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Mycobacterium tuberculosis Conserved protein 0.0027 0.0028 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0005 0.0002
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.0092 0.0183
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0358 0.0872 0.3369
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0056 0.0209
Schistosoma mansoni opsin-like receptor 0.0084 0.0173 0.0469
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0232 0.0232
Brugia malayi FAD linked oxidases, C-terminal domain containing protein 0.0027 0.0028 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.0137 0.0528
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0179
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1707 0.431 0.8706
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0173 0.0469
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.2735
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0004 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0358 0.0872 0.3369
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0358 0.0872 0.3369
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0143 0.0324 0.0881
Echinococcus granulosus nAChR subunit 0.0358 0.0872 0.1759
Onchocerca volvulus 0.0193 0.0451 0.3752
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Entamoeba histolytica hypothetical protein 0.0076 0.0154 0.3087
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0026 0.0097
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Schistosoma mansoni nAChR subunit 0.0358 0.0872 0.2379
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0324 0.1253
Onchocerca volvulus 0.0165 0.0381 0.3146
Echinococcus granulosus sex peptide receptor 0.0084 0.0173 0.0347
Echinococcus granulosus serotonin receptor 0.0084 0.0173 0.0347
Entamoeba histolytica hypothetical protein 0.0193 0.0451 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0143 0.0324 0.1253
Echinococcus granulosus tm gpcr rhodopsin 0.1959 0.4951 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0056 0.021
Onchocerca volvulus 0.0084 0.0173 0.1366
Chlamydia trachomatis UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase 0.1443 0.3638 0.3603
Schistosoma mansoni neurotransmitter gated ion channel 0.0165 0.0381 0.1036
Loa Loa (eye worm) hypothetical protein 0.0055 0.01 0.0336
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0358 0.0872 0.3369
Echinococcus multilocularis g protein coupled receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0158 0.0362 0.1222
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0055 0.0205
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.103 0.2585 0.5221
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Mycobacterium tuberculosis Conserved protein 0.0107 0.0232 0.023
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0005 0.0004
Treponema pallidum folylpolyglutamate synthetase (folC) 0.1443 0.3638 0.36
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.1026 0.2574 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0084 0.0173 0.0347
Brugia malayi neuropeptide F receptor 0.0084 0.0173 0.0664
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Echinococcus granulosus folylpolyglutamate synthase, mitochondrial 0.0479 0.118 0.2382
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0005 0.0002
Brugia malayi hypothetical protein 0.0056 0.0102 0.0391
Brugia malayi Dopamine receptor 0.0084 0.0173 0.0664
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Onchocerca volvulus 0.0193 0.0451 0.3752
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0059 0.0229
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0019 0.0047
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0086 0.0086
Leishmania major cytochrome p450-like protein 0.0018 0.0005 0.0013
Onchocerca volvulus 0.0049 0.0085 0.0614
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0024 0.0045
Mycobacterium ulcerans UDP-N-acetylmuramate--L-alanine ligase 0.2517 0.6373 0.6373
Leishmania major actin interacting protein-like protein 0.0027 0.0028 0.0104
Treponema pallidum UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (murE) 0.1764 0.4456 0.4423
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0121 0.0326
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0086 0.0086
Brugia malayi G protein-coupled receptor 0.0084 0.0173 0.0664
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Mycobacterium leprae PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) 0.1443 0.3638 0.3647
Echinococcus granulosus glycine receptor subunit alpha 1 0.0358 0.0872 0.1759
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0005 0.0012
Brugia malayi G-protein coupled receptor 0.0084 0.0173 0.0664
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0092 0.028
Trypanosoma cruzi multidrug resistance protein E, putative 0.0028 0.003 0.0113
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.0246 0.0246
Mycobacterium ulcerans flavoprotein 0.0027 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0125 0.0278 0.094
Mycobacterium ulcerans polyketide synthase 0.0026 0.0025 0.0025
Leishmania major cytochrome p450-like protein 0.0018 0.0005 0.0013
Onchocerca volvulus Huntingtin homolog 0.0125 0.0278 0.227
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0232 0.0828
Echinococcus granulosus multidrug resistance associated protein 4 0.0021 0.0014 0.0026
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0143 0.0324 0.0651
Echinococcus granulosus tachykinin peptides receptor 99D 0.0084 0.0173 0.0347
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni nAChR subunit 0.0358 0.0872 0.2379
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0005 0.0004
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0084 0.0173 0.0664
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0143 0.0324 0.0881
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0059 0.0116
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0358 0.0872 0.1759
Mycobacterium tuberculosis Conserved protein 0.0107 0.0232 0.023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0053 0.0105
Loa Loa (eye worm) hypothetical protein 0.0044 0.0071 0.0237
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0479 0.118 0.2382
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0232 0.023
Brugia malayi larval opioid receptor 0.0084 0.0173 0.0664
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0165 0.0381 0.1287
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0026 0.0051
Schistosoma mansoni histamine h1 receptor 0.0084 0.0173 0.0469
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0358 0.0872 0.2954
Schistosoma mansoni biogenic amine receptor 0.0084 0.0173 0.0469
Leishmania major pentamidine resistance protein 1 0.0028 0.003 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0324 0.1187
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.0217 0.0214
Echinococcus granulosus tm gpcr rhodopsin 0.0084 0.0173 0.0347
Brugia malayi Bromodomain containing protein 0.008 0.0164 0.0631
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Mycobacterium tuberculosis Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) 0.1443 0.3638 0.3645
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0084 0.0173 0.0469
Echinococcus multilocularis nAChR subunit 0.0193 0.0451 0.0909
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0004 0.001
Giardia lamblia hypothetical protein 0.0143 0.0324 0.1007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0059 0.0056
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0143 0.0324 0.0651
Chlamydia trachomatis UDP-N-acetylenolpyruvoylglucosamine reductase 0.393 0.9975 0.9975
Echinococcus granulosus orexin receptor type 2 0.0084 0.0173 0.0347
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0027 0.0098
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0084 0.0173 0.0347
Schistosoma mansoni amine GPCR 0.0084 0.0173 0.0469
Giardia lamblia Multidrug resistance-associated protein 1 0.0028 0.003 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0005 0.0002
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0021 0.0065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0079 0.0156
Echinococcus multilocularis dna polymerase kappa 0.007 0.0137 0.0275
Brugia malayi hypothetical protein 0.0084 0.0173 0.0664
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0358 0.0872 0.3369
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Echinococcus granulosus glycine receptor subunit beta 0.0358 0.0872 0.1759
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0092 0.0353
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0092 0.0183
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Entamoeba histolytica hypothetical protein 0.0076 0.0154 0.3087
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Brugia malayi polk-prov protein 0.0044 0.0071 0.0271
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0028 0.003 0.0113
Echinococcus multilocularis neuropeptide s receptor 0.0084 0.0173 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0137 0.0534
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0084 0.0173 0.0347
Echinococcus multilocularis g protein coupled receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0096
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0358 0.0872 0.1759
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0232 0.0466
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0143 0.0324 0.1247
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.008 0.0159
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0086 0.1519
Mycobacterium leprae putative cytochrome p450 0.0018 0.0005 0.0004
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.2735
Schistosoma mansoni hypothetical protein 0.0038 0.0056 0.0149
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Brugia malayi cytochrome P450 0.0018 0.0005 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0026 0.0097
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0017 0.0003 0.0003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0026 0.0068
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0005 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.007 0.0137 0.0534
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.001 0.0007
Schistosoma mansoni amine GPCR 0.0084 0.0173 0.0469
Echinococcus granulosus dna polymerase eta 0.0038 0.0056 0.0109
Schistosoma mansoni hypothetical protein 0.0017 0.0004 0.0008
Echinococcus multilocularis G-protein coupled receptor, putative 0.0084 0.0173 0.0347
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0358 0.0872 0.3369
Schistosoma mansoni multidrug resistance protein 0.0028 0.003 0.0079
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0026 0.0097
Schistosoma mansoni neuropeptide f receptor 76f 0.0084 0.0173 0.0469
Onchocerca volvulus 0.0084 0.0173 0.1366
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0084 0.0173 0.0469
Leishmania major D-lactate dehydrogenase-like protein 0.0027 0.0028 0.0104
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0006 0.001
Echinococcus granulosus biogenic amine 5HT receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Treponema pallidum UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (murF) 0.1764 0.4456 0.4423
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0102 0.0392
Loa Loa (eye worm) hypothetical protein 0.0047 0.008 0.0268
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0084 0.0173 0.0582
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0084 0.0173 0.0347
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0683 0.1699 0.1701
Loa Loa (eye worm) hypothetical protein 0.0241 0.0575 0.1945
Echinococcus granulosus G protein coupled receptor 139 0.0084 0.0173 0.0347
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.0104 0.04
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0011 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0026 0.0085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0026 0.0051
Onchocerca volvulus 0.0084 0.0173 0.1366
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0005 0.0004
Trichomonas vaginalis esterase, putative 0.0107 0.0232 0.0828
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0358 0.0872 0.2954
Schistosoma mansoni coup transcription factor 0.0026 0.0026 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0324 0.1253
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0193 0.0451 0.1741
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0232 0.0828
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0092 0.0214
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0121 0.0404
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0017 0.0003 0.0003
Brugia malayi Cytochrome P450 family protein 0.0018 0.0005 0.0013
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0165 0.0381 0.0766
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0143 0.0324 0.1253
Onchocerca volvulus 0.0084 0.0173 0.1366
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0024 0.0045
Echinococcus multilocularis mitogen activated protein kinase 3 0.1026 0.2574 0.5199
Chlamydia trachomatis UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminoligase 0.1764 0.4456 0.4425
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0232 0.0828
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.0104 0.0349
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0056 0.0109
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0026 0.0068
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0056 0.0184
Echinococcus granulosus neuropeptide receptor A26 0.0084 0.0173 0.0347
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0026 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0005 0.0002
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0143 0.0324 0.1253
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0358 0.0872 0.2379
Schistosoma mansoni hypothetical protein 0.0017 0.0004 0.0008
Brugia malayi multidrug resistance related protein 1 0.0028 0.003 0.0112
Mycobacterium leprae possible oxidoreductase 0.0027 0.0028 0.0028
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0005 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0137 0.0534
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0104 0.0255
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0324 0.1253
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0026 0.0051
Trypanosoma cruzi folylpolyglutamate synthetase 0.0479 0.118 0.4581
Loa Loa (eye worm) hypothetical protein 0.0107 0.0232 0.0783
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0025 0.0022
Brugia malayi neuropeptide F receptor 0.0084 0.0173 0.0664
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0005 0.0004
Echinococcus multilocularis neuropeptide Y receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.0304 0.1025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0173 0.0469
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0001 0.0005
Leishmania major folylpolyglutamate synthetase 0.0479 0.118 0.4581
Onchocerca volvulus Putative nachr subunit 0.0358 0.0872 0.7359
Brugia malayi sulfakinin receptor protein 0.0084 0.0173 0.0664
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0116 0.0231
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0143 0.0324 0.2735
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0026 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0056 0.0052
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0028 0.003 0.0113
Echinococcus multilocularis glycine receptor subunit beta 0.0358 0.0872 0.1759
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0086 0.0085
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0084 0.0173 0.0469
Onchocerca volvulus 0.0084 0.0173 0.1366
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0358 0.0872 0.2379
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0184
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0085
Brugia malayi hypothetical protein 0.0165 0.0381 0.1468
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0026 0.0068
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0232 0.023
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0026 0.0097
Toxoplasma gondii hypothetical protein 0.0165 0.0379 0.1282
Brugia malayi alkyldihydroxyacetonephosphate synthase 0.0027 0.0028 0.0104
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0084 0.0173 0.0347
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylenolpyruvoylglucosamine reductase 0.393 0.9975 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0143 0.0324 0.0881
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0193 0.0451 0.1741
Trypanosoma brucei protein kinase, putative 0.1026 0.2574 1
Mycobacterium tuberculosis Probable UDP-N-acetylenolpyruvoylglucosamine reductase MurB (UDP-N-acetylmuramate dehydrogenase) 0.393 0.9975 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0358 0.0872 0.2954
Echinococcus granulosus glycine receptor subunit beta 0.0358 0.0872 0.1759
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0019 0.0035
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.0575 0.1159
Echinococcus multilocularis tar DNA binding protein 0.0135 0.0304 0.061
Trypanosoma cruzi actin interacting protein-like protein, putative 0.0027 0.0028 0.0104
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Echinococcus multilocularis 0.0018 0.0005 0.0007
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0004 0.0006
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0005 0.0013
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0005 0.0004
Schistosoma mansoni opsin-like receptor 0.0084 0.0173 0.0469
Echinococcus granulosus 7TM GPCR rhodopsin 0.0084 0.0173 0.0347
Echinococcus granulosus g protein coupled receptor 0.0084 0.0173 0.0347
Onchocerca volvulus 0.0084 0.0173 0.1366
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0173 0.0469
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0086 0.0085
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.2735
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0115 0.0309
Mycobacterium tuberculosis Possible alkyldihydroxyacetonephosphate synthase AgpS (alkyl-DHAP synthase) (alkylglycerone-phosphate synthase) 0.0027 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0143 0.0324 0.0651
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni folylpolyglutamate synthase 0.0479 0.118 0.322
Schistosoma mansoni hypothetical protein 0.0049 0.0085 0.0229
Trypanosoma brucei unspecified product 0.0026 0.0026 0.01
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0143 0.0324 0.2735
Echinococcus multilocularis neuropeptide receptor 0.0084 0.0173 0.0347
Mycobacterium tuberculosis Probable UDP-N-acetylmuramate-alanine ligase MurC 0.0753 0.1878 0.188
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0026 0.0051
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0165 0.0381 0.1468
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0076 0.0295
Loa Loa (eye worm) hypothetical protein 0.0193 0.0451 0.1526
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.2735
Loa Loa (eye worm) hypothetical protein 0.0042 0.0066 0.022
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0086 0.0329
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0358 0.0872 0.2954
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0004 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.007 0.0137 0.0137
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.003 0.0226
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0104 0.0328
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0358 0.0872 0.1759
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.01 0.0336
Brugia malayi hypothetical protein 0.0076 0.0154 0.0589
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0358 0.0872 0.1759
Brugia malayi Cation transporter family protein 0.0358 0.0872 0.3369
Brugia malayi hypothetical protein 0.0084 0.0173 0.0664
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0026 0.0085
Echinococcus granulosus multidrug resistance associated protein 7 0.0028 0.003 0.0059
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0035 0.0068
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0005 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0026 0.0051
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0092 0.0308
Brugia malayi ecdysteroid receptor 0.0026 0.0026 0.0097
Loa Loa (eye worm) melatonin receptor type 1A 0.0084 0.0173 0.0582
Loa Loa (eye worm) FolC protein 0.0479 0.118 0.3999
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0084 0.0173 0.1366
Echinococcus granulosus alpha 1A adrenergic receptor 0.0084 0.0173 0.0347
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0116 0.0312
Loa Loa (eye worm) multidrug resistance-associated protein 0.0021 0.0015 0.0045
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0005 0.0004
Brugia malayi hypothetical protein 0.0084 0.0173 0.0664
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1173 0.2949 0.8053
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0005 0.0004
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.0304 0.1169
Onchocerca volvulus 0.0107 0.0232 0.1873
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0079 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0173 0.0469
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0027 0.0103
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0143 0.0324 0.1187
Loa Loa (eye worm) hypothetical protein 0.1173 0.2949 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0358 0.0872 0.3369
Brugia malayi Serotonin receptor 0.0084 0.0173 0.0664
Plasmodium vivax protein kinase Crk2 0.0052 0.0092 0.077
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0028 0.003 0.0118
Loa Loa (eye worm) hypothetical protein 0.0165 0.0379 0.1282
Loa Loa (eye worm) hypothetical protein 0.0056 0.0102 0.0343
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Echinococcus granulosus mitogen activated protein kinase 3 0.1026 0.2574 0.5199
Mycobacterium tuberculosis Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.1764 0.4456 0.4465
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0358 0.0872 0.1759
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Mycobacterium ulcerans hypothetical protein 0.0107 0.0232 0.0232
Schistosoma mansoni tyrosine kinase 0.0491 0.1212 0.3306
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0104 0.0328
Plasmodium vivax dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0479 0.118 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.01 0.0383
Trypanosoma brucei folylpolyglutamate synthase, putative 0.0479 0.118 0.4584
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0179
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0179
Schistosoma mansoni hypothetical protein 0.0084 0.0173 0.0469
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0358 0.0872 0.1759
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0003 0.0007
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Loa Loa (eye worm) neuropeptide F receptor 0.0084 0.0173 0.0582
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0084 0.0173 0.0664
Schistosoma mansoni acetylcholine receptor subunit beta 0.0165 0.0381 0.1036
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0232 0.0783
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0232 0.063
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0125 0.0249
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0165 0.0381 0.0766
Brugia malayi Cation transporter family protein 0.0358 0.0872 0.3369
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0025 0.0022
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0026 0.0109
Brugia malayi ABC transporter transmembrane region family protein 0.0028 0.003 0.0112
Echinococcus multilocularis serotonin receptor 0.0084 0.0173 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0071 0.0277
Schistosoma mansoni hypothetical protein 0.0084 0.0173 0.0469
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Brugia malayi FolC bifunctional protein 0.0479 0.118 0.4562
Echinococcus granulosus biogenic amine 5HT receptor 0.0084 0.0173 0.0347
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0115 0.0114
Schistosoma mansoni multidrug resistance protein 0.0028 0.003 0.0079
Loa Loa (eye worm) hypothetical protein 0.0193 0.0451 0.1526
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0358 0.0872 0.2379
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0232 0.023
Loa Loa (eye worm) hypothetical protein 0.0143 0.0324 0.1093
Schistosoma mansoni nAChR subunit 0.0358 0.0872 0.2379
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Loa Loa (eye worm) ACC-1 protein 0.0358 0.0872 0.2954
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0006 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0232 0.0897
Echinococcus multilocularis epidermal growth factor receptor 0.0924 0.2315 0.4674
Brugia malayi AMP-binding enzyme family protein 0.005 0.0086 0.0328
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0143 0.0324 0.1258
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0143 0.0324 0.0881
Brugia malayi putative neuropeptide receptor 0.0084 0.0173 0.0664
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.008 0.0233
Echinococcus granulosus peptide allatostatin:somatostatin 0.0084 0.0173 0.0347
Onchocerca volvulus 0.0165 0.0381 0.3146
Schistosoma mansoni alpha-1 adrenergic receptor 0.0084 0.0173 0.0469
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0143 0.0324 0.1253
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.0354 0.0713
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0232 0.1957
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0324 0.1187
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0005 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0003 0.0003
Trypanosoma brucei p-glycoprotein 0.0028 0.003 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.0137 0.0528
Brugia malayi hypothetical protein 0.0084 0.0173 0.0664
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Brugia malayi excitatory GABA receptor EXP-1A 0.0358 0.0872 0.3369
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.01 0.0383
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0165 0.0381 0.1468
Echinococcus multilocularis fmrfamide receptor 0.0084 0.0173 0.0347
Schistosoma mansoni acetylcholine receptor-related 0.0165 0.0381 0.1036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0084 0.0173 0.0347
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0143 0.0324 0.0881
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0017 0.0003 0.0003
Echinococcus granulosus glycine receptor subunit alpha 1 0.0358 0.0872 0.1759
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0085
Onchocerca volvulus Putative folylpolyglutamate synthase 0.0479 0.118 1
Echinococcus multilocularis epidermal growth factor receptor 0.0497 0.1225 0.2472
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase 0.0479 0.118 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0079 0.0299
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0065 0.1019
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0076 0.0073
Schistosoma mansoni tyrosine kinase 0.0924 0.2315 0.632
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0143 0.0324 0.0651
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0324 0.1253
Brugia malayi hypothetical protein 0.0165 0.0381 0.1468
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0165 0.0381 0.0766
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0102 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0026 0.0097
Loa Loa (eye worm) hypothetical protein 0.0165 0.0381 0.1287
Trypanosoma cruzi L-galactonolactone oxidase, putative 0.0027 0.0028 0.0104
Mycobacterium leprae Probable lipase LipE 0.0107 0.0232 0.0232
Echinococcus granulosus neuropeptide FF receptor 2 0.0084 0.0173 0.0347
Plasmodium falciparum importin beta, putative 0.0029 0.0035 0.0284
Onchocerca volvulus 0.0084 0.0173 0.1366
Loa Loa (eye worm) hypothetical protein 0.0107 0.0232 0.0783
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0143 0.0324 0.0881
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.103 0.2585 0.5221
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0028 0.003 0.0113
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1173 0.2949 0.5956
Echinococcus multilocularis dna polymerase eta 0.0038 0.0056 0.0109
Schistosoma mansoni multidrug resistance protein 0.0028 0.003 0.0079
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.003 0.0226
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0092 0.0248
Trypanosoma cruzi alkyl-dihydroxyacetone phosphate synthase, putative 0.0027 0.0028 0.0104
Onchocerca volvulus 0.0358 0.0872 0.7359
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0005 0.0002
Echinococcus granulosus microtubule associated protein 2 0.1453 0.3662 0.7396
Trypanosoma brucei unspecified product 0.0062 0.0117 0.0455
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.0104 0.0874
Plasmodium falciparum phosphodiesterase gamma, putative 0.0143 0.0324 0.2735
Schistosoma mansoni neurotransmitter gated ion channel 0.0193 0.0451 0.1229
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.001 0.0029
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0092 0.0353
Giardia lamblia MRP-like ABC transporter 0.0028 0.003 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0079 0.0211
Mycobacterium ulcerans oxidoreductase 0.0027 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0026 0.0097
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0092 0.1664
Loa Loa (eye worm) hypothetical protein 0.0043 0.0069 0.0228
Brugia malayi hypothetical protein 0.0084 0.0173 0.0664
Echinococcus granulosus hypothetical protein 0.0084 0.0173 0.0347
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.003 0.0226
Brugia malayi Dopamine receptor protein 2 0.0084 0.0173 0.0664
Giardia lamblia ABC transporter, putative 0.0028 0.003 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.0217 0.0214
Schistosoma mansoni neuropeptide F-like receptor 0.0084 0.0173 0.0469
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0165 0.0381 0.1287
Echinococcus granulosus neuropeptides capa receptor 0.0084 0.0173 0.0347
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0143 0.0324 0.0651
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0059 0.01
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0295 0.0712 0.1436
Treponema pallidum UDP-N-acetylenolpyruvoylglucosamine reductase 0.393 0.9975 0.9975
Echinococcus granulosus protein kinase shaggy 0.0057 0.0104 0.0208
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0115 0.0112
Loa Loa (eye worm) hypothetical protein 0.0107 0.0232 0.0783
Echinococcus granulosus multidrug resistance associated protein 1 0.0028 0.003 0.0059
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0085
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0358 0.0872 0.3369
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0053 0.0105
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0086 0.0329
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Mycobacterium ulcerans UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.1764 0.4456 0.4455
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.0092 0.0353
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0324 0.1093
Echinococcus multilocularis multidrug resistance associated protein 7 0.0028 0.003 0.0059
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0065 0.0536
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0193 0.0451 0.1741
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0056 0.0109
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0173 0.0469
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0358 0.0872 0.1759
Loa Loa (eye worm) LGC-31 protein 0.0358 0.0872 0.2954
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0084 0.0173 0.0469
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0026 0.0051
Schistosoma mansoni hypothetical protein 0.1237 0.3112 0.8498
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.0575 0.1159
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0059 0.0488
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0036 0.0052 0.0049
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0193 0.0451 0.1741
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0086 0.0085
Trypanosoma cruzi folylpolyglutamate synthase, putative 0.0479 0.118 0.4581
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0021 0.0021
Trypanosoma cruzi L-galactonolactone oxidase 0.0027 0.0028 0.0104
Mycobacterium tuberculosis Possible ligase 0.0479 0.118 0.118
Onchocerca volvulus 0.0158 0.0362 0.2982
Onchocerca volvulus 0.0084 0.0173 0.1366
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0028 0.003 0.0098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0049 0.0046
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0021 0.0021
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0143 0.0324 0.1187
Onchocerca volvulus 0.0057 0.0104 0.0778
Mycobacterium tuberculosis Possible oxidoreductase 0.0027 0.0028 0.0025
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0084 0.0173 0.0664
Schistosoma mansoni nAChR subunit 0.0358 0.0872 0.2379
Schistosoma mansoni amine GPCR 0.0084 0.0173 0.0469
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0143 0.0324 0.1258
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0026 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0026 0.0085
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0582
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0173 0.0347
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0092 0.0248
Echinococcus granulosus snurportin 1 0.0314 0.076 0.1533
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0086 0.0085
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0115 0.0384
Loa Loa (eye worm) hypothetical protein 0.0165 0.0379 0.1282
Echinococcus multilocularis g protein coupled receptor 0.0084 0.0173 0.0347
Leishmania major trypanothione reductase 0.0044 0.0073 0.0277
Echinococcus multilocularis 0.0286 0.0689 0.1389
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0059 0.015
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0143 0.0324 0.1187
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0358 0.0872 0.1759
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0154 0.0308
Brugia malayi Cation transporter family protein 0.0358 0.0872 0.3369
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0287
Echinococcus granulosus neuropeptide s receptor 0.0084 0.0173 0.0347
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0358 0.0872 0.1759

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 209 nM In vitro effective dose of the compound against [35S]-GTP-gammaS, binding to rat brain membranes ChEMBL. 14736254
Ki (binding) = 23.4 nM Displacement of [3H]-endomorphin-2 from Opioid receptor mu 1 of rat brain membranes ChEMBL. 14736254
Ki (binding) = 23.4 nM Displacement of [3H]-endomorphin-2 from Opioid receptor mu 1 of rat brain membranes ChEMBL. 14736254
Ki (binding) = 26.3 nM Displacement of [3H]-DAMGO from Opioid receptor mu 1 of rat brain membranes ChEMBL. 14736254
Ki (binding) = 26.3 nM Displacement of [3H]-DAMGO from Opioid receptor mu 1 of rat brain membranes ChEMBL. 14736254
Ki (binding) = 65.4 nM Displacement of [3H]-Dynorphin A from Opioid receptor kappa 1 of rat brain membranes (DAMGO/DADLE quenching of mu/delta receptor binding) ChEMBL. 14736254
Ki (binding) = 65.4 nM Displacement of [3H]-Dynorphin A from Opioid receptor kappa 1 of rat brain membranes (DAMGO/DADLE quenching of mu/delta receptor binding) ChEMBL. 14736254
Ki (binding) = 4630 nM Displacement of [3H]Ile5,6-deltorphin II from opioid receptor delta 1 of rat brain membranes ChEMBL. 14736254
Ki (binding) = 4630 nM Displacement of [3H]Ile5,6-deltorphin II from opioid receptor delta 1 of rat brain membranes ChEMBL. 14736254
Max stimulation (functional) = 126 % In vitro percent maximal stimulation of [35S]-GTP-gammaS, binding by the compound in rat brain membranes ChEMBL. 14736254
Ratio (binding) = 176 Relative affinity for delta and kappa opioid receptors ChEMBL. 14736254

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.