Detailed information for compound 699088

Basic information

Technical information
  • TDR Targets ID: 699088
  • Name: 3-methyl-7-[(4-methylphenyl)methyl]-8-piperaz in-1-ylpurine-2,6-dione
  • MW: 354.406 | Formula: C18H22N6O2
  • H donors: 2 H acceptors: 3 LogP: 1.15 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Cn1c(nc2c1c(=O)[nH]c(=O)n2C)N1CCNCC1
  • InChi: 1S/C18H22N6O2/c1-12-3-5-13(6-4-12)11-24-14-15(22(2)18(26)21-16(14)25)20-17(24)23-9-7-19-8-10-23/h3-6,19H,7-11H2,1-2H3,(H,21,25,26)
  • InChiKey: XFJCVDAIIPQXKB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-methyl-7-[(4-methylphenyl)methyl]-8-piperazin-1-yl-purine-2,6-dione
  • 3-methyl-7-[(4-methylphenyl)methyl]-8-(1-piperazinyl)purine-2,6-dione
  • 3-methyl-7-(4-methylbenzyl)-8-piperazin-1-yl-xanthine
  • Oprea1_100547
  • 3-Methyl-7-(4-methyl-benzyl)-8-piperazin-1-yl-3,7-dihydro-purine-2,6-dione
  • ST5009710
  • BAS 01541690

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Macaaca fascicularis T-complex protein 1 subunit beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Neospora caninum TCP-1/cpn60 family chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Giardia lamblia TCP-1 chaperonin subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania major T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania infantum T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum ko:K09494 T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania donovani T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Toxoplasma gondii t-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Theileria parva T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium vivax T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Cryptosporidium hominis TCP-1/cpn60 chaperonin-related protein Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis chaperonin-60kD, ch60, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium knowlesi T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium falciparum T-complex protein 1 subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium yoelii putative T-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Cryptosporidium parvum GroEL-like chaperone (ATpase); T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Babesia bovis T-complex protein beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania braziliensis T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Entamoeba histolytica T-complex protein 1 beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania mexicana T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium berghei T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania mexicana T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 35.1 %
Plasmodium knowlesi T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.1 %
Leishmania infantum T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 550 aa 32.9 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 545 aa 29.7 %
Dictyostelium discoideum chaperonin containing TCP1 alpha subunit T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Cryptosporidium hominis CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 536 aa 28.4 %
Plasmodium berghei T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Trypanosoma cruzi T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Echinococcus granulosus t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Leishmania donovani chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.5 %
Trypanosoma cruzi chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 547 aa 26.0 %
Toxoplasma gondii TCP-1 chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 26.9 %
Schistosoma japonicum ko:K09493 T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 585 aa 31.5 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Entamoeba histolytica chaperonin containing TCP-1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 508 aa 32.7 %
Babesia bovis T-complex protein 1 zeta subunit T-complex protein 1 subunit beta   535 aa 532 aa 26.7 %
Cryptosporidium parvum TCP-1/cpn60 chaperonin family, T-complex protein subunit 7 (eta) T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Neospora caninum Thermosome subunit, related T-complex protein 1 subunit beta   535 aa 527 aa 31.3 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Leishmania major T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.3 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Plasmodium falciparum T-complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 23.1 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Entamoeba histolytica T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 31.6 %
Schistosoma japonicum ko:K09496 T-complex protein 1 subunit delta, putative T-complex protein 1 subunit beta   535 aa 533 aa 32.1 %
Cryptosporidium parvum T complex chaperonin T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 604 aa 22.9 %
Echinococcus granulosus T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 34.0 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 542 aa 27.7 %
Schistosoma mansoni chaperonin containing t-complex protein 1 eta subunit tcph T-complex protein 1 subunit beta   535 aa 536 aa 32.8 %
Giardia lamblia TCP-1 chaperonin subunit gamma T-complex protein 1 subunit beta   535 aa 561 aa 29.8 %
Giardia lamblia TCP-1 chaperonin subunit zeta T-complex protein 1 subunit beta   535 aa 516 aa 24.8 %
Leishmania infantum T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.4 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Plasmodium yoelii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 523 aa 30.0 %
Entamoeba histolytica T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 29.9 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 533 aa 33.8 %
Plasmodium vivax T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Giardia lamblia TCP-1 chaperonin subunit eta T-complex protein 1 subunit beta   535 aa 543 aa 32.0 %
Giardia lamblia TCP-1 chaperonin subunit epsilon T-complex protein 1 subunit beta   535 aa 535 aa 31.6 %
Leishmania infantum chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Plasmodium falciparum T-complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 539 aa 23.4 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 575 aa 23.1 %
Theileria parva T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 522 aa 32.4 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, gamma subunit, tcpg, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Trypanosoma cruzi T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 29.5 %
Echinococcus granulosus T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 517 aa 27.1 %
Trypanosoma brucei T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Trichomonas vaginalis rubisco subunit binding-protein alpha subunit, ruba, putative T-complex protein 1 subunit beta   535 aa 580 aa 23.3 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, beta subunit, tcpb, putative T-complex protein 1 subunit beta   535 aa 541 aa 35.5 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.2 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 533 aa 28.3 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Leishmania infantum chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Dictyostelium discoideum chaperonin containing TCP1 eta subunit T-complex protein 1 subunit beta   535 aa 528 aa 33.5 %
Echinococcus multilocularis t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Loa Loa (eye worm) T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 514 aa 26.5 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Trypanosoma brucei gambiense T-complex protein 1, theta subunit, putative,CCT-theta, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Schistosoma japonicum ko:K09498 T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 552 aa 25.7 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Plasmodium berghei T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 523 aa 30.2 %
Plasmodium yoelii T-complex protein 1 epsilon subunit T-complex protein 1 subunit beta   535 aa 508 aa 32.9 %
Leishmania donovani T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.8 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 528 aa 20.8 %
Leishmania major T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.8 %
Babesia bovis TCP-1/cpn60 chaperonin family protein T-complex protein 1 subunit beta   535 aa 538 aa 30.5 %
Echinococcus multilocularis T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Leishmania mexicana T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.6 %
Leishmania major chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.3 %
Cryptosporidium hominis t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Neospora caninum GL18351, related T-complex protein 1 subunit beta   535 aa 530 aa 26.2 %
Dictyostelium discoideum chaperonin containing TCP1 theta subunit T-complex protein 1 subunit beta   535 aa 501 aa 27.1 %
Mycobacterium tuberculosis 60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (a T-complex protein 1 subunit beta   535 aa 565 aa 23.5 %
Plasmodium vivax heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 540 aa 21.9 %
Plasmodium yoelii chaperonin, 60 kDa T-complex protein 1 subunit beta   535 aa 530 aa 34.9 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Echinococcus granulosus T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Leishmania donovani T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Leishmania mexicana chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.3 %
Brugia malayi T-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 534 aa 35.6 %
Brugia malayi T-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 529 aa 28.4 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 547 aa 32.7 %
Trypanosoma brucei T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 549 aa 35.7 %
Trypanosoma brucei T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.4 %
Leishmania major T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 28.8 %
Trypanosoma brucei gambiense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Toxoplasma gondii T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.8 %
Plasmodium yoelii putative chaperonin T-complex protein 1 subunit beta   535 aa 497 aa 22.7 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 550 aa 32.0 %
Plasmodium berghei T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 537 aa 23.5 %
Plasmodium knowlesi T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 526 aa 31.0 %
Leishmania braziliensis chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Schistosoma mansoni chaperonin containing t-complex protein 1 epsilon subunit tcpe T-complex protein 1 subunit beta   535 aa 505 aa 33.9 %
Dictyostelium discoideum chaperonin containing TCP1 epsilon subunit T-complex protein 1 subunit beta   535 aa 520 aa 34.4 %
Leishmania braziliensis chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 542 aa 26.2 %
Leishmania braziliensis chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Trypanosoma brucei gambiense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Neospora caninum hypothetical protein T-complex protein 1 subunit beta   535 aa 531 aa 29.0 %
Leishmania major T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.5 %
Trypanosoma brucei T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Plasmodium knowlesi T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.7 %
Trypanosoma brucei gambiense T-complex protein 1, eta subunit, putative,t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.4 %
Trypanosoma congolense t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Entamoeba histolytica hypothetical protein T-complex protein 1 subunit beta   535 aa 516 aa 22.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Trypanosoma cruzi chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 528 aa 33.0 %
Cryptosporidium parvum putative t-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 545 aa 28.3 %
Giardia lamblia TCP-1 chaperonin subunit theta T-complex protein 1 subunit beta   535 aa 563 aa 25.2 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Leishmania infantum chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.7 %
Leishmania mexicana T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.2 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 561 aa 23.0 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Leishmania infantum T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Leishmania braziliensis T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Cryptosporidium parvum conserved probable chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.7 %
Brugia malayi T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 502 aa 26.3 %
Theileria parva T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 27.1 %
Babesia bovis t-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Plasmodium vivax T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.4 %
Schistosoma mansoni chaperonin containing t-complex protein 1 gamma subunit tcpg T-complex protein 1 subunit beta   535 aa 552 aa 29.7 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 546 aa 33.7 %
Trypanosoma congolense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.4 %
Plasmodium yoelii T-complex protein 1 T-complex protein 1 subunit beta   535 aa 534 aa 26.2 %
Loa Loa (eye worm) CCT-5 protein T-complex protein 1 subunit beta   535 aa 521 aa 31.3 %
Trypanosoma brucei gambiense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Cryptosporidium hominis T-complex protein 1 T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Trypanosoma brucei T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Plasmodium falciparum T-complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 546 aa 34.4 %
Brugia malayi T-complex protein 1, epsilon subunit T-complex protein 1 subunit beta   535 aa 513 aa 31.4 %
Plasmodium berghei T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 539 aa 34.1 %
Leishmania braziliensis T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Echinococcus multilocularis chaperonin containing TCP1, subunit 5 (epsilon) T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Leishmania donovani T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Schistosoma mansoni chaperonin containing t-complex protein 1 theta subunit tcpq T-complex protein 1 subunit beta   535 aa 515 aa 27.2 %
Schistosoma mansoni chaperonin containing t-complex protein 1 zeta subunit tcpz T-complex protein 1 subunit beta   535 aa 544 aa 26.3 %
Giardia lamblia TCP-1 chaperonin subunit alpha T-complex protein 1 subunit beta   535 aa 528 aa 32.6 %
Trypanosoma brucei gambiense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Trypanosoma brucei T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Trypanosoma cruzi chaperonin/T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 30.9 %
Babesia bovis T-complex protein 1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 32.6 %
Brugia malayi T-complex protein 1, eta subunit T-complex protein 1 subunit beta   535 aa 534 aa 33.1 %
Trichomonas vaginalis chaperonin-60kD, ch60, putative T-complex protein 1 subunit beta   535 aa 538 aa 33.6 %
Plasmodium vivax T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 539 aa 22.4 %
Trypanosoma congolense T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 28.6 %
Echinococcus granulosus T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.5 %
Echinococcus multilocularis T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Echinococcus granulosus chaperonin containing TCP1 subunit 5 epsilon T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Trypanosoma brucei gambiense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, epsilon subunit, tcpe, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 29.8 %
Trypanosoma congolense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 521 aa 29.6 %
Schistosoma japonicum ko:K09499 T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Leishmania major chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Drosophila melanogaster T-complex Chaperonin 5 T-complex protein 1 subunit beta   535 aa 506 aa 34.6 %
Cryptosporidium parvum t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Leishmania infantum T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Plasmodium falciparum T-complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 542 aa 34.9 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 579 aa 23.1 %
Plasmodium knowlesi T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 544 aa 23.5 %
Plasmodium vivax T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.3 %
Trypanosoma brucei t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.6 %
Trypanosoma congolense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 525 aa 34.1 %
Entamoeba histolytica chaperonin-containing TCP-1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 550 aa 23.5 %
Onchocerca volvulus Integrator complex subunit 3 homolog T-complex protein 1 subunit beta   535 aa 534 aa 35.8 %
Toxoplasma gondii T-complex protein 1 delta subunit T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Plasmodium vivax T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Plasmodium berghei T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 526 aa 25.7 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 561 aa 27.1 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Entamoeba histolytica chaperonin containing TCP-1 delta subunit, putative T-complex protein 1 subunit beta   535 aa 531 aa 30.7 %
Cryptosporidium hominis CCTepsilon subunit T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Leishmania mexicana chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.6 %
Theileria parva T-complex protein 1, alpha subunit , putative T-complex protein 1 subunit beta   535 aa 527 aa 34.9 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 549 aa 20.6 %
Cryptosporidium parvum putative T complex chaperonin T-complex protein 1 subunit beta   535 aa 546 aa 25.1 %
Leishmania braziliensis T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Toxoplasma gondii T-complex protein 1, epsilon subunit (TCP-1-epsilon), putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Trypanosoma congolense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 32.2 %
Schistosoma japonicum ko:K09497 T-complex protein 1 subunit epsilon, putative T-complex protein 1 subunit beta   535 aa 505 aa 33.5 %
Entamoeba histolytica T-complex protein 1 theta subunit, putative T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Theileria parva chaperonin 60 kDa, putative T-complex protein 1 subunit beta   535 aa 544 aa 26.1 %
Brugia malayi T-complex protein 1, zeta subunit T-complex protein 1 subunit beta   535 aa 517 aa 27.7 %
Babesia bovis HSP60 fold T-complex protein 1, putative T-complex protein 1 subunit beta   535 aa 497 aa 28.0 %
Dictyostelium discoideum chaperonin containing TCP1 zeta subunit T-complex protein 1 subunit beta   535 aa 523 aa 26.6 %
Plasmodium falciparum T-complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 522 aa 29.9 %
Drosophila melanogaster CG8351 gene product from transcript CG8351-RA T-complex protein 1 subunit beta   535 aa 527 aa 32.3 %
Echinococcus multilocularis T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 27.1 %
Plasmodium knowlesi T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 33.7 %
Babesia bovis heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 530 aa 22.3 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Toxoplasma gondii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 531 aa 29.2 %
Leishmania braziliensis T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 29.1 %
Leishmania mexicana chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 538 aa 26.8 %
Toxoplasma gondii T complex chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.0 %
Leishmania donovani chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Trypanosoma cruzi T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 29.7 %
Schistosoma mansoni T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) T-complex protein 1 subunit beta   535 aa 552 aa 33.5 %
Theileria parva T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 580 aa 33.3 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 33.5 %
Cryptosporidium hominis chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.9 %
Leishmania major chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.1 %
Schistosoma mansoni chaperonin containing t-complex protein 1 delta subunit tcpd T-complex protein 1 subunit beta   535 aa 530 aa 32.8 %
Toxoplasma gondii T-complex protein 1 eta subunit T-complex protein 1 subunit beta   535 aa 546 aa 33.9 %
Leishmania donovani chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Leishmania donovani T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni calpain (C02 family) 0.0082 0.0803 0.0802
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1747 0.1835
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0029
Mycobacterium leprae Probable lipase LipE 0.0071 0.0669 0.4973
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0071 0.0661 0.1184
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0071 0.0661 0.1184
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0104 0.0102
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0027
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0002 0.0004
Giardia lamblia Cathepsin B precursor 0.0094 0.0946 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0002 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0104 0.1098
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0084 0.0821 0.1923
Plasmodium vivax vivapain-2 0.0025 0.0104 0.1273
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0041 0.0293 0.4111
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0706 0.7465
Echinococcus multilocularis caspase 2 0.0062 0.0552 0.058
Trichomonas vaginalis hypothetical protein 0.0025 0.0096 0.1016
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0028 0.03
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0669 0.0667
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0051 0.0053
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0026 0.0027
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0022 0.0058 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Trypanosoma cruzi oligopeptidase b 0.0118 0.1236 0.2896
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0226 0.0627
Brugia malayi proprotein convertase 2 0.0026 0.0107 0.0106
Leishmania major C-8 sterol isomerase-like protein 0.0358 0.4182 0.9796
Trypanosoma cruzi prolyl endopeptidase 0.0276 0.3177 0.7443
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0029 0.0151 0.0353
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0057 0.1007
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0058 0.0608
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0094 0.0946 0.0944
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0367 0.0385
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0171 0.018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0025
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0669 0.0644
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.215 0.3957
Brugia malayi celfurPC protein 0.0026 0.0107 0.0106
Trypanosoma cruzi prefoldin subunit, putative 0.0062 0.0553 0.1295
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0026 0.0366
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0028 0.0331
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0669 0.0667
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0057 0.0134
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0706 0.7465
Plasmodium vivax prefoldin subunit 6, putative 0.0062 0.0553 0.6872
Mycobacterium leprae putative cytochrome p450 0.0071 0.0661 0.4908
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0058 0.0608
Loa Loa (eye worm) hypothetical protein 0.0276 0.3177 0.3159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Brugia malayi Cytochrome P450 family protein 0.0071 0.0661 0.066
Brugia malayi nuclear hormone receptor 0.0021 0.0051 0.0049
Echinococcus granulosus cathepsin l1 0.0025 0.0104 0.0183
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0189 0.2108 0.2107
Onchocerca volvulus 0.0136 0.1462 0.4542
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.2714 0.2695
Leishmania major cathepsin L-like protease 0.0025 0.0104 0.0183
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0104 0.0078
Trypanosoma brucei oligopeptidase b 0.0118 0.1236 0.2896
Loa Loa (eye worm) prolyl oligopeptidase 0.0195 0.2184 0.2164
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0096 0.0225
Echinococcus granulosus cathepsin l cysteine peptidase 0.0025 0.0104 0.0183
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0311 0.3614 0.3796
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0026 0.0107 0.0383
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0082 0.0803 0.1832
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0094 0.0946 1
Brugia malayi endoprotease bli-4 precursor 0.0026 0.0107 0.0106
Brugia malayi Cathepsin L-like precursor 0.0025 0.0104 0.0102
Trichomonas vaginalis calpain, putative 0.0025 0.0096 0.1016
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0058 0.0608
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0026 0.0027
Trypanosoma brucei Calpain-like protein 1.2 0.0025 0.0096 0.0225
Onchocerca volvulus 0.0071 0.0669 0.2019
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0029 0.0151 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0363
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0058 0.006
Loa Loa (eye worm) hypothetical protein 0.0279 0.321 0.3193
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0071 0.0661 0.1184
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0008
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0058 0.0608
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0028 0.0482
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0058 0.0608
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0669 0.1197
Loa Loa (eye worm) subtilase 0.0832 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0025 0.0104 0.1852
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.0661 0.0637
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0026 0.0107 0.0106
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0832 1 1
Brugia malayi cathepsin L-like precursor 0.002 0.0034 0.0032
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0706 0.0742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0051 0.0025
Trypanosoma brucei cysteine peptidase, putative 0.0025 0.0096 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0051 0.0049
Echinococcus multilocularis hypothetical protein 0.0082 0.0803 0.0844
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0051 0.0089
Loa Loa (eye worm) hypothetical protein 0.0041 0.0293 0.0267
Toxoplasma gondii hypothetical protein 0.0025 0.0096 0.0215
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0669 0.1197
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0025 0.0096 0.0225
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0082 0.0803 0.1882
Leishmania major hypothetical protein, conserved 0.0071 0.0669 0.1515
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0051 0.0049
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0029 0.0151 0.2118
Echinococcus granulosus jumonji domain containing protein 0.0043 0.032 0.0565
Brugia malayi Cathepsin L-like precursor 0.0025 0.0104 0.0102
Brugia malayi beta-lactamase 0.0071 0.0669 0.0667
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0025 0.0096 0.0225
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0084 0.0821 0.0862
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0051 0.0049
Onchocerca volvulus 0.0071 0.0669 0.2019
Loa Loa (eye worm) T-complex protein 1 0.0029 0.0151 0.0125
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0082 0.0803 0.1882
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0669 0.1567
Loa Loa (eye worm) hypothetical protein 0.0071 0.0669 0.0644
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.1035 0.1087
Echinococcus granulosus cathepsin L cysteine proteinase 0.0025 0.0104 0.0183
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0151 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Brugia malayi Protein kinase domain containing protein 0.0022 0.0057 0.0055
Leishmania major T-complex protein 1, beta subunit, putative 0.0029 0.0151 0.0294
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0051 0.0089
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0058 0.0608
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0071 0.0661 0.1184
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0575 0.0551
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Toxoplasma gondii ABC1 family protein 0.0071 0.0669 0.2034
Toxoplasma gondii subtilisin SUB11 0.0026 0.0107 0.0251
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0276 0.3177 0.3176
Echinococcus multilocularis cysteine protease 0.0025 0.0104 0.0109
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0051 0.0052
Brugia malayi Bromodomain containing protein 0.0031 0.0171 0.017
Loa Loa (eye worm) beta-lactamase 0.0071 0.0669 0.0644
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Brugia malayi cathepsin B-like cysteine proteinase 0.0279 0.321 0.3209
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0051 0.0052
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0051 0.0052
Echinococcus granulosus calpain 7 C02 family 0.0082 0.0803 0.1418
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0058 0.006
Leishmania major hypothetical protein, conserved 0.0022 0.0057 0.0074
Brugia malayi Cytochrome P450 family protein 0.0071 0.0661 0.066
Schistosoma mansoni jumonji domain containing protein 0.008 0.0779 0.0778
Schistosoma mansoni inositol monophosphatase 0.0074 0.0706 0.0705
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0251 0.0264
Toxoplasma gondii subtilisin SUB1 0.0026 0.0107 0.0251
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.0661 0.0637
Onchocerca volvulus Cell death protein 3 homolog 0.0062 0.0552 0.1648
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0669 0.7068
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0051 0.0089
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0028 0.005
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0118 0.1236 0.2896
Mycobacterium tuberculosis Conserved protein 0.0022 0.0062 0.0067
Trypanosoma brucei calpain-like protein, putative 0.0082 0.0803 0.1882
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0118 0.1236 1
Trypanosoma brucei kinesin, putative 0.0058 0.0499 0.117
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0071 0.0661 0.1184
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0051 0.0049
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0028 0.0067
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0226 0.2387
Leishmania major kinesin, putative 0.0058 0.0499 0.1116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0104 0.1098
Echinococcus multilocularis calpain A 0.0232 0.2639 0.2771
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0051 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0025 0.0096 0.1016
Trypanosoma brucei cytochrome P450, putative 0.0071 0.0661 0.155
Brugia malayi hypothetical protein 0.0043 0.032 0.0318
Leishmania major cysteine peptidase A (CPA) 0.0025 0.0104 0.0183
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0002 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0002 0.0026
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0058 0.0608
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0195 0.2184 0.2294
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0071 0.0661 0.155
Echinococcus multilocularis apoptotic protease activating factor 1 0.0062 0.0552 0.058
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0669 0.1197
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0026 0.0107 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0367 0.0365
Loa Loa (eye worm) hypothetical protein 0.0189 0.2108 0.2087
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0071 0.0661 0.2992
Leishmania major cathepsin L-like protease 0.0025 0.0104 0.0183
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Loa Loa (eye worm) hypothetical protein 0.0479 0.5667 0.5655
Schistosoma mansoni hypothetical protein 0.0062 0.0553 0.0551
Loa Loa (eye worm) hypothetical protein 0.0071 0.0669 0.0644
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0071 0.0661 0.1184
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0226 0.0529
Leishmania major hypothetical protein, unknown function 0.0025 0.0096 0.0165
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0104 0.0109
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Toxoplasma gondii hypothetical protein 0.0041 0.0293 0.084
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0082 0.0803 0.1882
Leishmania major hypothetical protein, conserved 0.0025 0.0102 0.0179
Echinococcus multilocularis cathepsin b 0.0279 0.321 0.3372
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0071 0.0661 0.1184
Echinococcus multilocularis survival motor neuron protein 1 0.0479 0.5667 0.5952
Trichomonas vaginalis abcb9, putative 0.0022 0.0058 0.0608
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0084 0.0821 0.1923
Brugia malayi Cathepsin L-like precursor 0.0025 0.0104 0.0102
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0058 0.0608
Trypanosoma brucei calpain-like protein, putative 0.0082 0.0803 0.1882
Entamoeba histolytica protein kinase, putative 0.0058 0.0499 0.701
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0195 0.2184 0.3855
Trichomonas vaginalis abcb9, putative 0.0022 0.0058 0.0608
Loa Loa (eye worm) hypothetical protein 0.0071 0.0669 0.0644
Schistosoma mansoni survival motor neuron protein 0.0098 0.099 0.0989
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0096 0.0225
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0669 0.1197
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0051 0.0089
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Trypanosoma brucei antigen, putative 0.0082 0.0803 0.1882
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0669 0.1197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0712 0.0711
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0104 0.1098
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0071 0.0661 0.1184
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0669 0.1197
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0611 0.4457
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0071 0.0661 0.2992
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0071 0.0661 0.1184
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0026 0.0024
Trypanosoma brucei Calpain-like protein CALP1.3 0.0025 0.0096 0.0225
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0051 0.0053
Schistosoma mansoni Mername-AA248 (C02 family) 0.0082 0.0803 0.0802
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.5393 1
Echinococcus granulosus Furin 1 0.0026 0.0107 0.0189
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0293 0.0291
Leishmania major p-glycoprotein 0.0022 0.0058 0.0074
Loa Loa (eye worm) fibroinase 0.0025 0.0104 0.0078
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0102 0.0239
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0055 0.0057
Plasmodium falciparum calpain 0.0025 0.0096 0.1711
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0706 0.1655
Onchocerca volvulus 0.0026 0.0107 0.0232
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Trichomonas vaginalis taga, putative 0.0022 0.0058 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Echinococcus granulosus cathepsin L 0.0017 0.0002 0.0003
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0025 0.0096 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Schistosoma mansoni calpain-7 (C02 family) 0.0082 0.0803 0.0802
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0311 0.3614 0.6378
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.1135
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0071 0.0661 0.2992
Brugia malayi Cathepsin L-like precursor 0.0025 0.0104 0.0102
Trypanosoma brucei Calpain-like protein 2 0.0025 0.0096 0.0225
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0051 0.0049
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0025 0.0096 0.0215
Brugia malayi hypothetical protein 0.0062 0.0552 0.055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0104 0.1098
Brugia malayi ecdysteroid receptor 0.0021 0.0051 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.1135
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0104 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0096 0.1016
Echinococcus multilocularis calpain 0.0082 0.0803 0.0844
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0071 0.0661 0.1184
Echinococcus granulosus furin 0.0026 0.0107 0.0189
Plasmodium falciparum T-complex protein 1 subunit beta 0.0029 0.0151 0.2705
Brugia malayi Cytochrome P450 family protein 0.0071 0.0661 0.066
Echinococcus multilocularis neuroendocrine convertase 2 0.0026 0.0107 0.0113
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0034 0.0032
Brugia malayi ABC transporter family protein 0.0022 0.0058 0.0056
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0669 0.0702
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0026 0.0107 0.0383
Loa Loa (eye worm) hypothetical protein 0.0043 0.032 0.0295
Loa Loa (eye worm) endoprotease bli-4 0.0026 0.0107 0.0081
Brugia malayi Cell death protein 3 precursor 0.0062 0.0552 0.055
Trichomonas vaginalis esterase, putative 0.0071 0.0669 0.7068
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0071 0.0661 0.155
Schistosoma mansoni multidrug resistance protein 0.0022 0.0058 0.0056
Mycobacterium tuberculosis Conserved protein 0.0071 0.0669 0.1197
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0026 0.0107 0.0113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0051 0.0049
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0104 0.1458
Plasmodium falciparum subtilisin-like protease 2 0.0026 0.0107 0.1915
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0151 0.0149
Echinococcus multilocularis membrane bound transcription factor site 1 0.0026 0.0107 0.0113
Loa Loa (eye worm) hypothetical protein 0.0062 0.0553 0.0528
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0025 0.0096 0.0225
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0071 0.0661 0.2992
Plasmodium falciparum prefoldin subunit 6, putative 0.0062 0.0553 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0226 0.0399
Mycobacterium ulcerans lipase LipD 0.0071 0.0669 0.3026
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0022 0.0058 0.0093
Plasmodium falciparum subtilisin-like protease 3 0.0026 0.0107 0.1915
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0029 0.0151 0.0353
Loa Loa (eye worm) hypothetical protein 0.0041 0.0293 0.0267
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0051 0.0049
Loa Loa (eye worm) hypothetical protein 0.0136 0.1462 0.1439
Loa Loa (eye worm) hypothetical protein 0.0062 0.0552 0.0527
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0002 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.1135
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0226 0.02
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Leishmania major hypothetical protein, conserved 0.0022 0.0062 0.0085
Brugia malayi hypothetical protein 0.0025 0.0102 0.01
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0094 0.0946 0.2217
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0082 0.0803 0.1882
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0151 0.0149
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0057 0.0692
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0712 0.0748
Plasmodium vivax multidrug resistance protein 1, putative 0.0022 0.0058 0.0695
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0029 0.0151 0.0158
Echinococcus granulosus membrane bound transcription factor site 1 0.0026 0.0107 0.0189
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0026 0.0107 0.0251
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0232 0.2636 0.2635
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.1747 0.1725
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0669 0.832
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0071 0.0661 0.1184
Schistosoma mansoni calpain C (C02 family) 0.0082 0.0803 0.0802
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0022 0.0058 0.0059
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0026 0.0061
Toxoplasma gondii prefoldin subunit 6, putative 0.0062 0.0553 0.1665
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0025 0.0104 0.1852
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Trypanosoma brucei Calpain-like protein 1.1 0.0025 0.0096 0.0225
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0226 0.2387
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0026 0.0107 0.0151
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0025
Loa Loa (eye worm) hypothetical protein 0.0071 0.0669 0.0644
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0118 0.1236 0.5698
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0102 0.125
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0025 0.0096 0.1016
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0151 0.0149
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0082 0.0803 0.1882
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0669 0.7068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0071 0.0661 0.1184
Brugia malayi calpain 5 0.0025 0.0096 0.0094
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0226 0.2387
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Brugia malayi KE2 family protein 0.0062 0.0553 0.0551
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Schistosoma mansoni multidrug resistance protein 0.0022 0.0058 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0051 0.0089
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0058 0.0608
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0028 0.0002
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0058 0.0608
Trichomonas vaginalis abcb9, putative 0.0022 0.0058 0.0608
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0096 0.0225
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0367 0.0365
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0118 0.1236 0.2896
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0071 0.0661 0.2992
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Echinococcus granulosus cathepsin b 0.0279 0.321 0.5665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0002 0.002
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0235 0.2676 0.4938
Schistosoma mansoni alpha-glucosidase 0.0137 0.1475 0.1473
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0058 0.0608
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0057 0.0092
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0025 0.0104 0.0078
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0041 0.0293 0.3095
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0058 0.006
Mycobacterium ulcerans hypothetical protein 0.0022 0.0062 0.0169
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.9521 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0226 0.0471
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0058 0.0608
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0706 0.7465
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0058 0.0608
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0026 0.0061
Entamoeba histolytica P-glycoprotein-5 0.0022 0.0058 0.0808
Trypanosoma brucei prefoldin subunit, putative 0.0062 0.0553 0.1295
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0071 0.0661 0.2992
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0279 0.321 0.3209
Brugia malayi jmjC domain containing protein 0.0101 0.1035 0.1033
Loa Loa (eye worm) calpain D 0.0025 0.0096 0.007
Onchocerca volvulus 0.0022 0.0058 0.0074
Loa Loa (eye worm) proprotein convertase 2 0.0026 0.0107 0.0081
Leishmania major calpain family cysteine protease-like protein 0.0025 0.0096 0.0165
Brugia malayi MH2 domain containing protein 0.0238 0.2714 0.2713
Leishmania major cytochrome p450-like protein 0.0071 0.0661 0.1498
Toxoplasma gondii cytochrome p450 superfamily protein 0.0071 0.0661 0.2011
Giardia lamblia Cathepsin B precursor 0.0094 0.0946 1
Schistosoma mansoni alpha glucosidase 0.0035 0.0226 0.0224
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0051 0.0053
Loa Loa (eye worm) hypothetical protein 0.0161 0.1766 0.1744
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4268 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0195 0.2184 0.6842
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0058 0.0608
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0104 0.1458
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Giardia lamblia Hypothetical protein 0.0062 0.0553 0.5723
Onchocerca volvulus 0.0071 0.0669 0.2019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0051 0.0049
Echinococcus granulosus acylamino acid releasing enzyme 0.0041 0.0293 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Echinococcus granulosus apoptotic protease activating factor 1 0.0062 0.0552 0.0974
Echinococcus multilocularis 0.0026 0.0107 0.0113
Echinococcus granulosus neuroendocrine convertase 2 0.0026 0.0107 0.0189
Trypanosoma cruzi kinesin, putative 0.0058 0.0499 0.117
Trypanosoma brucei calpain-like protein, putative 0.0082 0.0803 0.1882
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0421 0.0987
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0025 0.0096 0.1016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Brugia malayi beta-lactamase family protein 0.0071 0.0669 0.0667
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0028 0.0067
Toxoplasma gondii subtilisin SUB12 0.004 0.0279 0.0795
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0026 0.0107 0.0106
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0021 0.0055 0.0096
Entamoeba histolytica hypothetical protein 0.0075 0.0712 1
Onchocerca volvulus 0.0025 0.0104 0.0221
Giardia lamblia TCP-1 chaperonin subunit beta 0.0029 0.0151 0.1356
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0041 0.0293 0.084
Toxoplasma gondii hypothetical protein 0.0059 0.0514 0.1542
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0051 0.0049
Trypanosoma brucei unspecified product 0.0019 0.0026 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Schistosoma mansoni calpain-7 (C02 family) 0.0082 0.0803 0.0802
Mycobacterium ulcerans hypothetical protein 0.0071 0.0669 0.3026
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0082 0.0803 0.1882
Echinococcus multilocularis calpain 5 0.0082 0.0803 0.0844
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0071 0.0661 0.1184
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0084 0.0821 0.1873
Brugia malayi PHD-finger family protein 0.0031 0.0171 0.017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0104 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0104 0.1098
Echinococcus granulosus Dipeptidyl peptidase 9 0.0084 0.0821 0.1448
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0171 0.0303
Mycobacterium ulcerans beta-lactamase 0.0071 0.0669 0.3026
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0057 0.0031
Plasmodium falciparum phd finger protein, putative 0.0031 0.0171 0.308
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0025 0.0096 0.1016
Onchocerca volvulus Alhambra homolog 0.0031 0.0171 0.0436
Schistosoma mansoni smdr2 0.0022 0.0058 0.0056
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0232 0.2636 0.2635
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Schistosoma mansoni cytochrome P450 0.0071 0.0661 0.066
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0096 0.0225
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0071 0.0669 0.0644
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0041 0.0293 0.0686
Trypanosoma cruzi cytochrome P450, putative 0.0071 0.0661 0.155
Echinococcus granulosus cathepsin l1 0.002 0.0034 0.0061
Entamoeba histolytica P-glycoprotein-1 0.0022 0.0058 0.0808
Entamoeba histolytica P-glycoprotein 5, putative 0.0022 0.0058 0.0808
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0104 0.1098
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0096 0.0225
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0051 0.0049
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0051 0.0089
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0118 0.1236 0.2255
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0051 0.0049
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0026 0.0024
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0026 0.0046
Echinococcus multilocularis prefoldin subunit 6 0.0062 0.0553 0.058
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0071 0.0661 0.155
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0226 0.2387
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0706 0.1603
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0058 0.0102
Brugia malayi Cathepsin L-like precursor 0.0025 0.0104 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0041 0.0293 0.0291
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0071 0.0661 0.2992
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0669 0.4973
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0104 0.0221
Brugia malayi cytochrome P450 0.0071 0.0661 0.066
Schistosoma mansoni calpain-2 (C02 family) 0.0025 0.0096 0.0094
Loa Loa (eye worm) cysteine protease 0.0025 0.0104 0.0078
Onchocerca volvulus 0.0021 0.0051 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0226 0.0224
Brugia malayi prolyl oligopeptidase family protein 0.0276 0.3177 0.3176
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0058 0.0102
Leishmania major cathepsin L-like protease 0.0025 0.0104 0.0183
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0026 0.0107 0.0251
Toxoplasma gondii subtilisin SUB8 0.0026 0.0107 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0051 0.0049
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0626 0.1466
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0071 0.0661 0.1184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0051 0.0025
Loa Loa (eye worm) prolyl oligopeptidase 0.0041 0.0293 0.0267
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0082 0.0803 0.1882
Trypanosoma cruzi conserved protein 0.0025 0.0096 0.0225
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0058 0.0608
Leishmania major cathepsin L-like protease 0.0025 0.0104 0.0183
Trypanosoma cruzi prefoldin subunit, putative 0.0062 0.0553 0.1295
Giardia lamblia Alanyl dipeptidyl peptidase 0.0041 0.0293 0.2899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0051 0.0025
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0026 0.0107 0.0189
Echinococcus granulosus dna polymerase kappa 0.0019 0.0026 0.0046
Trypanosoma brucei calpain-like protein, putative 0.0082 0.0803 0.1882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0028 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0071 0.0661 0.1184
Echinococcus granulosus cysteine protease 0.0017 0.0002 0.0003
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0029 0.0151 0.1595
Echinococcus granulosus prefoldin subunit 6 0.0062 0.0553 0.0975
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0058 0.0608
Trypanosoma brucei hypothetical protein 0.0025 0.0096 0.0225
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0171 0.0454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0002 0.0004
Plasmodium vivax subtilisin-like protease 2, putative 0.0026 0.0107 0.1316
Loa Loa (eye worm) hypothetical protein 0.0071 0.0669 0.0644
Entamoeba histolytica hypothetical protein 0.0075 0.0712 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0051 0.0089
Trypanosoma cruzi subtilisin peptidase 0.0026 0.0107 0.0251
Onchocerca volvulus Prolyl endopeptidase homolog 0.0276 0.3177 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.1035 0.1826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Leishmania major cathepsin L-like protease 0.0074 0.0695 0.1577
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0367 0.0385
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0025
Loa Loa (eye worm) hypothetical protein 0.0194 0.2169 0.2149
Schistosoma mansoni hypothetical protein 0.0031 0.0171 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0051 0.0089
Echinococcus multilocularis cathepsin L 0.0017 0.0002 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0058 0.0608
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0026 0.0107 0.0251
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0102 0.182
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0081
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0218 0.2473 0.2472
Echinococcus granulosus dna polymerase eta 0.0019 0.0026 0.0046
Loa Loa (eye worm) inositol-1 0.0074 0.0706 0.0682
Entamoeba histolytica prefoldin subunit 6, putative 0.0062 0.0553 0.7758
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0062 0.0145
Giardia lamblia Alanyl dipeptidyl peptidase 0.0041 0.0293 0.2899
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0094 0.0946 0.2169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.0661 0.0637
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0058 0.0608
Loa Loa (eye worm) hypothetical protein 0.0189 0.2108 0.2087
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0071 0.0661 0.1184
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0118 0.1236 0.2896
Mycobacterium tuberculosis Conserved protein 0.0071 0.0669 0.1197
Schistosoma mansoni hypothetical protein 0.0062 0.0552 0.055
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0071 0.0661 0.1498
Schistosoma mansoni site-1 peptidase (S08 family) 0.0026 0.0107 0.0106
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Brugia malayi calpain D 0.0025 0.0096 0.0094
Echinococcus multilocularis cathepsin b 0.0279 0.321 0.3372
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0712 0.1257
Brugia malayi steroid hormone receptor 0.0021 0.0051 0.0049
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0028 0.0027
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0071 0.0661 0.2992
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0171 0.0454
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Leishmania major cathepsin L-like protease 0.0074 0.0695 0.1577
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0028 0.0399
Onchocerca volvulus 0.0025 0.0104 0.0221
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.1747 0.3083
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Brugia malayi calpain family protein 1 0.0218 0.2473 0.2472
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0028 0.0011
Echinococcus multilocularis prolyl endopeptidase 0.0276 0.3177 0.3337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Trichomonas vaginalis calpain, putative 0.0025 0.0096 0.1016
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0002 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0104 0.1098
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0189 0.2108 0.372
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Entamoeba histolytica calpain family cysteine protease, putative 0.0025 0.0096 0.1349
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0002 0.0004
Brugia malayi Inositol-1 0.0074 0.0706 0.0705
Schistosoma mansoni hypothetical protein 0.0071 0.0661 0.066
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Brugia malayi Cathepsin L-like cysteine proteinase 0.002 0.0034 0.0032
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0082 0.0803 0.1832
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0293 0.4111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0025
Giardia lamblia PHD finger protein 15 0.0031 0.0171 0.158
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0695 0.1629
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0071 0.0661 0.2992
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0051 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0025
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0421 0.0987
Loa Loa (eye worm) hypothetical protein 0.0218 0.2473 0.2453
Echinococcus multilocularis acylamino acid releasing enzyme 0.0041 0.0293 0.0308
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0026 0.0107 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Onchocerca volvulus 0.0189 0.2108 0.6598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0367 0.0365
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0051 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0102 0.182
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1911 0.4476
Echinococcus granulosus inhibitor of apoptosis protein 0.0189 0.2108 0.372
Echinococcus multilocularis Furin 1 0.0026 0.0107 0.0113
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0051 0.0049
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0058 0.0608
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0102 0.0234
Schistosoma mansoni hypothetical protein 0.0075 0.0712 0.0711
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0058 0.0608
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0022 0.0058 0.5
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0171 0.0146
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0051 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0051 0.0049
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0421 0.0987
Schistosoma mansoni multidrug resistance protein 0.0022 0.0058 0.0056
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0151 0.0149
Echinococcus granulosus calpain A 0.0082 0.0803 0.1418
Echinococcus granulosus cytochrome P450 2K1 0.0071 0.0661 0.1167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0002 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0669 0.7068
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0293 0.4111
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0084 0.0821 0.1923
Trypanosoma brucei calpain, putative 0.0025 0.0096 0.0225
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0082 0.0803 0.1832
Leishmania major subtilisin-like serine peptidase 0.0026 0.0107 0.0192
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0025
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0058 0.0608
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0226 0.2387
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0058 0.0608
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0051 0.0025
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0706 0.2153
Brugia malayi calpain 5 0.0058 0.0499 0.0498
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0195 0.2184 0.2183
Loa Loa (eye worm) cathepsin B 0.0094 0.0946 0.0922
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0358 0.4182 0.4181
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0022 0.0058 0.0074
Brugia malayi neuroendocrine convertase 1 precursor 0.0026 0.0107 0.0106
Onchocerca volvulus 0.0022 0.0057 0.0073
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0082 0.0803 0.1882
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0058 0.0102
Toxoplasma gondii subtilisin SUB5 0.0026 0.0107 0.0251
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0051 0.0053
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0051 0.0049
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0118 0.1236 0.2853
Plasmodium falciparum subtilisin-like protease 1 0.0026 0.0107 0.1915
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0706 1
Echinococcus multilocularis geminin 0.0205 0.2304 0.2419
Loa Loa (eye worm) calpain 0.0082 0.0803 0.0779
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1747 0.1835
Brugia malayi Cytochrome P450 family protein 0.0071 0.0661 0.066
Echinococcus granulosus calpain A 0.0232 0.2639 0.4657
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0251 0.0443
Loa Loa (eye worm) hypothetical protein 0.0183 0.2036 0.2015
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0293 0.363
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.4268 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0251 0.0226
Toxoplasma gondii subtilisin SUB9 0.0026 0.0107 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Loa Loa (eye worm) cytochrome P450 0.0071 0.0661 0.0637
Toxoplasma gondii prolyl endopeptidase 0.0276 0.3177 1
Schistosoma mansoni inositol monophosphatase 0.0074 0.0706 0.0705
Onchocerca volvulus Deterin homolog 0.0189 0.2108 0.6598
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.1747 0.1745
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4268 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0058 0.0608
Onchocerca volvulus 0.0025 0.0104 0.0221
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0232 0.2636 0.4651
Toxoplasma gondii subtilisin SUB4 0.0026 0.0107 0.0251
Schistosoma mansoni inhibitor of apoptosis protein 0.0189 0.2108 0.2107
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0032
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Plasmodium falciparum multidrug resistance protein 1 0.0022 0.0058 0.1011
Brugia malayi prolyl oligopeptidase family protein 0.0084 0.0821 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0026 0.0107 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0051 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0104 0.1098
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0226 0.2387
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0367 0.0647
Entamoeba histolytica cysteine protease, putative 0.0025 0.0104 0.1458
Schistosoma mansoni hypothetical protein 0.0025 0.0096 0.0094
Mycobacterium tuberculosis Conserved protein 0.0071 0.0669 0.1197
Brugia malayi Kringle domain containing protein 0.0022 0.0057 0.0055
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0071 0.0661 0.2992
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0071 0.0661 0.2992
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Mycobacterium ulcerans hypothetical protein 0.0192 0.215 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0071 0.0661 0.1184
Echinococcus granulosus calpain 0.0082 0.0803 0.1418
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0025 0.0096 0.0225
Trypanosoma brucei calpain, putative 0.0025 0.0096 0.0225
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0057 0.0101
Schistosoma mansoni hypothetical protein 0.0189 0.2108 0.2107
Echinococcus multilocularis inhibitor of apoptosis protein 0.0189 0.2108 0.2214
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0071 0.0661 0.1184
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0041 0.0293 0.3095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0022 0.0058 0.0093
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0026 0.0061
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0028 0.0004
Loa Loa (eye worm) hypothetical protein 0.0358 0.4182 0.4167
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0695 0.1629
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0071 0.0661 0.2992
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0096 0.0225
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0082 0.0803 0.1882
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.0076
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Leishmania major oligopeptidase b 0.0118 0.1236 0.2853
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0226 0.317
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0226 0.2387
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0051 0.0053
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0171 0.017
Brugia malayi Cathepsin L-like precursor 0.002 0.0034 0.0032
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0002 0.0004
Echinococcus multilocularis 0.0071 0.0661 0.0695
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0081
Loa Loa (eye worm) calpain family protein 1 0.0218 0.2473 0.2453
Schistosoma mansoni alpha-glucosidase 0.0137 0.1475 0.1473
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0611 0.1089
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.1135
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0706 0.1246
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0025 0.0096 0.0225
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0028 0.0025
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0102 0.0239
Plasmodium vivax subtilisin-like serine protease, putative 0.0026 0.0107 0.1316
Loa Loa (eye worm) ctsf protein 0.0025 0.0104 0.0078
Leishmania major cathepsin L-like protease 0.0025 0.0104 0.0183
Toxoplasma gondii subtilisin SUB6 0.0026 0.0107 0.0251
Echinococcus multilocularis calpain 7 (C02 family) 0.0082 0.0803 0.0844
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0082 0.0803 0.1882
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Echinococcus granulosus geminin 0.0205 0.2304 0.4065
Brugia malayi multidrug resistance protein 3 0.0022 0.0058 0.0056
Toxoplasma gondii subtilisin SUB10 0.0026 0.0107 0.0251
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0279 0.321 0.3209
Leishmania major hypothetical protein, conserved 0.0025 0.0096 0.0165
Leishmania major cytochrome p450-like protein 0.0071 0.0661 0.1498
Echinococcus multilocularis cysteine protease 0.0025 0.0104 0.0109
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0071 0.0661 0.1184
Trypanosoma cruzi major cysteine proteinase, putative 0.006 0.0524 0.1227
Schistosoma mansoni site-1 peptidase (S08 family) 0.0026 0.0107 0.0106
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0669 0.1567
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.4268 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0026 0.0107 0.0151
Brugia malayi nuclear receptor NHR-88 0.0021 0.0051 0.0049
Schistosoma mansoni hypothetical protein 0.0205 0.2304 0.2302
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0051 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0051 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0669 0.7068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0002 0.002
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0084 0.0821 0.2516
Mycobacterium tuberculosis Probable peptidase 0.0118 0.1236 0.2255
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0071 0.0661 0.2992
Toxoplasma gondii t-complex protein beta subunit 0.0029 0.0151 0.0389
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0026 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0171 0.2116
Loa Loa (eye worm) hypothetical protein 0.0062 0.0552 0.0527
Trypanosoma brucei subtilisin peptidase 0.0026 0.0107 0.0251
Leishmania major cytochrome p450-like protein 0.0071 0.0661 0.1498
Leishmania major prefoldin subunit, putative 0.0062 0.0553 0.1241
Trypanosoma cruzi kinesin, putative 0.0058 0.0499 0.117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Brugia malayi calpain family protein 1 0.0218 0.2473 0.2472
Loa Loa (eye worm) hypothetical protein 0.0022 0.0057 0.0031
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0706 0.3203
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Trypanosoma brucei cysteine peptidase C (CPC) 0.0094 0.0946 0.2217
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0002 0.0026
Leishmania major calpain protease-like protein 0.0025 0.0096 0.0165
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0025 0.0096 0.1016
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0104 0.0109
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0226 0.2387
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0293 0.0686
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0058 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0051 0.0049
Schistosoma mansoni hypothetical protein 0.0205 0.2304 0.2302
Treponema pallidum mcbG protein 0.0022 0.0062 1
Loa Loa (eye worm) CYP4Cod1 0.0071 0.0661 0.0637
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0051 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0051 0.0049
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0189 0.2108 0.2107
Loa Loa (eye worm) hypothetical protein 0.0025 0.0096 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0104 0.1098
Entamoeba histolytica P-glyco protein 6, putative 0.0022 0.0058 0.0808
Trypanosoma brucei prolyl endopeptidase 0.0276 0.3177 0.7443
Echinococcus multilocularis calpain family protein 1, d 0.0161 0.1766 0.1855
Brugia malayi jmjC domain containing protein 0.0037 0.0251 0.025
Echinococcus multilocularis dna polymerase eta 0.0019 0.0026 0.0027
Schistosoma mansoni coup transcription factor 0.0021 0.0051 0.0049
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0051 0.0025
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0669 0.1197
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0008
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0293 0.0291
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0367 0.0365
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0025
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0276 0.3177 0.7428
Echinococcus granulosus cathepsin b 0.0279 0.321 0.5665
Giardia lamblia Cathepsin B precursor 0.0094 0.0946 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0025 0.0104 0.1098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0051 0.0025
Echinococcus granulosus peregrin 0.0031 0.0171 0.0303
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0706 0.1655
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0051 0.0089
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0367 0.0342
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0026 0.0276
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0058 0.0608
Plasmodium vivax calpain, putative 0.0082 0.0803 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0028 0.003
Loa Loa (eye worm) multidrug resistance protein 3 0.0022 0.0058 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0034 0.0482
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0058 0.006
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0058 0.0102
Onchocerca volvulus 0.0092 0.0923 0.2827
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0706 0.1655
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0051 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0669 0.3026
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0026 0.0107 0.0151
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0058 0.006
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0071 0.0661 0.2992
Loa Loa (eye worm) calpain family protein 1 0.0161 0.1766 0.1744
Plasmodium vivax vivapain-2 0.0025 0.0104 0.1273
Entamoeba histolytica hypothetical protein 0.0075 0.0712 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0226 0.0237
Brugia malayi prolyl oligopeptidase family protein 0.0195 0.2184 0.2183
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0071 0.0661 0.2992
Echinococcus multilocularis peregrin 0.0031 0.0171 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0062 0.0145
Mycobacterium leprae Conserved hypothetical protein 0.0071 0.0661 0.4908
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0276 0.3177 0.3176
Schistosoma mansoni furin-1 (S08 family) 0.0026 0.0107 0.0106
Echinococcus granulosus calpain 5 0.0082 0.0803 0.1418
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0251 0.025
Brugia malayi calpain 7 0.0082 0.0803 0.0802
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0058 0.0102
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1911 0.4476
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0051 0.0025
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0071 0.0661 0.155
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0058 0.0102
Trypanosoma brucei glucosidase, putative 0.0035 0.0226 0.0529
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0058 0.0102
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0051 0.0053
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0695 0.1629
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0226 0.317
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0104 0.0102
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0279 0.321 0.3209
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0028 0.0005
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0706 0.9915
Toxoplasma gondii cathepsin B 0.0094 0.0946 0.2915
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0358 0.4182 0.9797
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0051 0.0049
Schistosoma mansoni hypothetical protein 0.0022 0.0057 0.0055
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0071 0.0661 0.2992
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0226 0.2387
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0279 0.321 0.7521
Schistosoma mansoni hypothetical protein 0.0098 0.099 0.0989
Entamoeba histolytica hypothetical protein 0.0075 0.0712 1
Echinococcus granulosus prolyl endopeptidase 0.0276 0.3177 0.5606
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0669 0.0667
Echinococcus granulosus survival motor neuron protein 1 0.0479 0.5667 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.1135
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0104 0.1098
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0071 0.0661 0.2992
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0058 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0025 0.0104 0.1098
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0057 0.006
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0041 0.0293 0.4111
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0084 0.0821 0.0819
Trypanosoma cruzi cytochrome P450, putative 0.0071 0.0661 0.155
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0051 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0226 0.0529
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0082 0.0803 0.1882
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0104 0.0102
Brugia malayi beta-lactamase family protein 0.0071 0.0669 0.0667
Schistosoma mansoni caspase-7 (C14 family) 0.0062 0.0552 0.055
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.032 0.0336
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0367 0.0647
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0071 0.0661 0.2992
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0553 0.5841
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0232 0.2636 0.2768
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0026 0.0107 0.0383
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0279 0.321 0.3209
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0025 0.0096 0.1016
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0293 0.0686
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0002 0.0026
Onchocerca volvulus 0.0062 0.0552 0.1648
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0041 0.0293 0.0291
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0695 0.1629
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0051 0.0053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0104 0.0078
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1911 0.4442
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0051 0.0049
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0082 0.0803 0.1882
Loa Loa (eye worm) calpain 5 0.0058 0.0499 0.0475
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0025 0.0104 0.1852
Trichomonas vaginalis calpain, putative 0.0025 0.0096 0.1016
Brugia malayi Cathepsin L-like precursor 0.0025 0.0104 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0363
Brugia malayi Cathepsin L-like precursor 0.002 0.0034 0.0032
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0058 0.0808
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0029 0.0151 0.1859
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Schistosoma mansoni DNA polymerase eta 0.0019 0.0026 0.0024
Onchocerca volvulus Cathepsin F homolog 0.0025 0.0104 0.0221
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0025 0.0096 0.0225
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0026 0.0024
Onchocerca volvulus 0.0098 0.099 0.3042
Entamoeba histolytica P-glycoprotein-2, putative 0.0022 0.0058 0.0808
Onchocerca volvulus 0.0025 0.0104 0.0221
Entamoeba histolytica cysteine protease, putative 0.0017 0.0002 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0669 0.7068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0061
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0026 0.0276
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0058 0.0608
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0062 0.1093
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.099 0.0989
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0189 0.2108 0.2214
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0104 0.0221
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0559 0.131
Trypanosoma brucei C-8 sterol isomerase, putative 0.0358 0.4182 0.9797
Brugia malayi hypothetical protein 0.0075 0.0712 0.0711
Onchocerca volvulus 0.0025 0.0104 0.0221
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0421 0.0987
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0028 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0293 0.3095
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0251 0.025
Trichomonas vaginalis chaperonin, putative 0.0029 0.0151 0.1595
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0669 0.118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0171 0.0146
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0058 0.006
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0071 0.0661 0.2992
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0026 0.0107 0.1135
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.2714 0.2695
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0084 0.0821 0.1923
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0104 0.0243
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0071 0.0661 0.2992
Entamoeba histolytica calpain large subunit domain III containing protein 0.0058 0.0499 0.701
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0669 0.3026
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0058 0.0808
Trypanosoma cruzi oligopeptidase b 0.0118 0.1236 0.2896
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0189 0.2108 0.2107
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0293 0.4111
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0293 0.4111
Toxoplasma gondii cathepsin CPL 0.0025 0.0104 0.024
Leishmania major cathepsin L-like protease 0.0074 0.0695 0.1577
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0002 0.0026
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0026 0.0107 0.0251
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0025
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0695 0.1629
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0026 0.0107 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0051 0.0025
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0026 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0051 0.0049
Loa Loa (eye worm) hypothetical protein 0.0053 0.0443 0.0418
Toxoplasma gondii subtilisin SUB7 0.0026 0.0107 0.0251
Onchocerca volvulus 0.0025 0.0104 0.0221
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0669 0.1567
Plasmodium vivax subtilisin-like protease 1 0.0026 0.0107 0.1316
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0071 0.0661 0.2992
Trypanosoma brucei prolyl oligopeptidase, putative 0.0118 0.1236 0.2896
Plasmodium falciparum peptidase, putative 0.0041 0.0293 0.5283
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0026 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0071 0.0661 0.1184
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0096 0.0165
Leishmania major hypothetical protein, conserved 0.0022 0.0062 0.0085
Toxoplasma gondii subtilisin SUB2 0.0026 0.0107 0.0251
Onchocerca volvulus 0.0025 0.0104 0.0221
Echinococcus granulosus caspase 2 0.0062 0.0552 0.0974
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0102 0.0239
Brugia malayi hypothetical protein 0.0479 0.5667 0.5666

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 25.17 uM PubChem BioAssay. MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_Dose_CherryPick_Activity_Set5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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