Detailed information for compound 222064

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 400.352 | Formula: C22H26BrNO
  • H donors: 1 H acceptors: 1 LogP: 5.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(Cc1ccc(cc1)Br)CN1C2CCC1CC(C2)c1ccccc1
  • InChi: 1S/C22H26BrNO/c23-19-8-6-16(7-9-19)12-22(25)15-24-20-10-11-21(24)14-18(13-20)17-4-2-1-3-5-17/h1-9,18,20-22,25H,10-15H2
  • InChiKey: IYFITMLPVWGURC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 18 (vesicular acetylcholine transporter), member 3 Starlite/ChEMBL References
Rattus norvegicus Dopamine transporter Starlite/ChEMBL References
Homo sapiens sigma non-opioid intracellular receptor 1 Starlite/ChEMBL References
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 Get druggable targets OG5_133283 All targets in OG5_133283
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative Get druggable targets OG5_133283 All targets in OG5_133283
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Onchocerca volvulus Vesicular acetylcholine transporter homolog Get druggable targets OG5_133283 All targets in OG5_133283
Schistosoma mansoni vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi vesicular acetylcholine transporter unc-17 Get druggable targets OG5_133283 All targets in OG5_133283
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 552 aa 41.5 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Serotonin transporter   630 aa 629 aa 47.1 %
Echinococcus multilocularis sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Dopamine transporter   619 aa 604 aa 37.9 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Serotonin transporter   630 aa 585 aa 34.2 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Serotonin transporter   630 aa 581 aa 40.1 %
Brugia malayi Abnormal catecholamine distribution protein 1 solute carrier family 18 (vesicular acetylcholine transporter), member 3 532 aa 504 aa 34.3 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Serotonin transporter   630 aa 520 aa 36.2 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 509 aa 28.3 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 31.8 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Neospora caninum sodium-dependent transporter, putative Dopamine transporter   619 aa 498 aa 32.3 %
Brugia malayi Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 30.9 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 605 aa 37.7 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Serotonin transporter   630 aa 638 aa 25.1 %
Onchocerca volvulus Serotonin transporter   630 aa 611 aa 26.4 %
Onchocerca volvulus Transmembrane protein 120 homolog Serotonin transporter   630 aa 571 aa 31.2 %
Echinococcus granulosus sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 582 aa 35.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0346 0.0501
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0014 0.0073 0.0719
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0022 0.0202 0.2076
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0026 0.0259 0.0395
Onchocerca volvulus 0.0032 0.0346 0.0877
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0017 0.0121 0.0175
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0009 0.0004 0.0006
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.0006 0.0004
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0009 0.0006 0.0024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0026 0.0259 0.7728
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.022 0.0318
Brugia malayi dehydrogenases, short chain protein 9 0.0009 0.0006 0.001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.001 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Schistosoma mansoni gabp alpha 0.0034 0.0376 0.0544
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0335 0.0335
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.0346 0.0528
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0009 0.0006 0.0024
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0339 0.0518
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0027 0.024
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0009 0.0006 0.0009
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0009 0.0006 0.0091
Schistosoma mansoni single-minded 0.0029 0.031 0.0448
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0036 0.0404 0.4192
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Onchocerca volvulus 0.0032 0.0346 0.0877
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0031 0.0335 0.0484
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0009 0.0004 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.0153 0.0233
Toxoplasma gondii oxidoreductase, putative 0.0009 0.0006 0.0067
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.0006 0.0091
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0026 0.0259 0.0374
Echinococcus granulosus eukaryotic initiation factor 4A 0.0011 0.0028 0.004
Loa Loa (eye worm) oxidoreductase 0.0009 0.0006 0.001
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0011 0.0028 0.0036
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0346 0.0501
Brugia malayi hypothetical protein 0.0031 0.0335 0.0511
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0949 0.9905
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0335 0.0484
Brugia malayi Cytochrome P450 family protein 0.0011 0.0027 0.0041
Echinococcus multilocularis serotonin transporter 0.0182 0.2612 0.2612
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0346 0.0501
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.0346 0.0501
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.0346 0.0501
Echinococcus multilocularis retinol dehydrogenase 11 0.0009 0.0006 0.0006
Echinococcus multilocularis conserved hypothetical protein 0.0009 0.0006 0.0006
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0009 0.0006 0.0009
Entamoeba histolytica short chain dehydrogenase family protein 0.0009 0.0006 0.0091
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0182 0.0272
Schistosoma mansoni hypothetical protein 0.0032 0.0346 0.0501
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Schistosoma mansoni lipoxygenase 0.0065 0.0851 0.1231
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.0346 0.0528
Echinococcus granulosus g protein coupled receptor 0.0032 0.0346 0.0501
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0009 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0445 0.6552 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0027 0.024
Entamoeba histolytica short chain dehydrogenase family protein 0.0009 0.0006 0.0091
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.6552 1
Loa Loa (eye worm) RecQ helicase 0.0021 0.0186 0.0284
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0026 0.0259 1
Schistosoma mansoni adenoreceptor 0.0032 0.0346 0.0501
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0346 0.0346
Schistosoma mansoni sodium-dependent amino acid transporter 0.0031 0.0335 0.0484
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0335 0.0484
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus granulosus bloom syndrome protein 0.0021 0.0186 0.027
Brugia malayi hypothetical protein 0.0017 0.0121 0.0184
Mycobacterium leprae Probable polyketide synthase Pks1 0.0036 0.0404 0.6461
Echinococcus multilocularis 0.0011 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0029 0.0302 0.0461
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0346 0.0501
Echinococcus multilocularis muscleblind protein 1 0.0221 0.3186 0.3186
Leishmania major eukaryotic initiation factor 4a, putative 0.0011 0.0028 0.0036
Giardia lamblia DINP protein human, muc B family 0.0009 0.0004 0.0157
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0011 0.0027 0.0243
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0346 0.0346
Onchocerca volvulus 0.0032 0.0346 0.0877
Leishmania major pteridine reductase 1 0.0009 0.0006 0.0004
Onchocerca volvulus 0.0031 0.0339 0.0859
Plasmodium falciparum flap endonuclease 1 0.0012 0.0051 0.1531
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Echinococcus granulosus carbonyl reductase 1 0.0009 0.0006 0.0009
Brugia malayi follicle stimulating hormone receptor 0.0032 0.0346 0.0528
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0346 0.0501
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0027 0.024
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0009 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0064 0.0834 0.1272
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0145 0.0222
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0027 0.024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0026 0.0259 0.0389
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0009 0.0006 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0027 0.024
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0346 0.0346
Schistosoma mansoni microtubule-associated protein tau 0.0468 0.6909 1
Onchocerca volvulus Fatty acid synthase homolog 0.006 0.0777 0.1988
Schistosoma mansoni lamin 0.0019 0.0153 0.0221
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0009 0.0006 0.0024
Brugia malayi PAS domain containing protein 0.0029 0.031 0.0473
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.0346 0.0528
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0009 0.0006 0.0009
Echinococcus granulosus orexin receptor type 2 0.0032 0.0346 0.0501
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Echinococcus granulosus g-protein coupled receptor 0.0032 0.0346 0.0501
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0006 0.0024
Onchocerca volvulus 0.0032 0.0346 0.0877
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0019 0.0155 0.1586
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Leishmania major short chain dehydrogenase, putative 0.0009 0.0006 0.0004
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0006 0.0024
Echinococcus granulosus GA binding protein alpha chain 0.0034 0.0376 0.0544
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0346 0.0528
Mycobacterium ulcerans thioesterase TesA 0.0028 0.0289 0.2984
Brugia malayi Dopamine receptor protein 1 0.0032 0.0346 0.0528
Loa Loa (eye worm) fli-1 protein 0.0102 0.1407 0.2148
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0033 0.0373 0.3864
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0009 0.0006 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0346 0.0501
Echinococcus granulosus importin subunit beta 1 0.0013 0.0071 0.0102
Leishmania major hypothetical protein, conserved 0.0009 0.0006 0.0004
Mycobacterium ulcerans polyketide synthase 0.0036 0.0404 0.4192
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Entamoeba histolytica Ran family GTPase 0.001 0.0018 0.0529
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.001 0.0021 0.0032
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0027 0.0039
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Leishmania major DNA polymerase eta, putative 0.0015 0.0089 0.013
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.0006 0.0091
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.007 0.0926 0.1414
Echinococcus multilocularis GA binding protein alpha chain 0.0034 0.0376 0.0376
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.0006 0.0091
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0346 0.0501
Echinococcus multilocularis serotonin receptor 0.0032 0.0346 0.0346
Mycobacterium ulcerans Type I modular polyketide synthase 0.0033 0.0373 0.3864
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0027 0.0035
Schistosoma mansoni biogenic amine receptor 0.0032 0.0346 0.0501
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0012 0.0051 0.0072
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0027 0.024
Mycobacterium ulcerans carveol-like dehydrogenase 0.0009 0.0006 0.0024
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.0958 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0346 0.0346
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0346 0.0501
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0033 0.0373 0.3864
Mycobacterium tuberculosis Probable thioesterase TesA 0.0028 0.0289 0.2984
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0346 0.0501
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0027 0.024
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0335 0.0484
Schistosoma mansoni lipoxygenase 0.0023 0.022 0.0318
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0027 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0346 0.0501
Echinococcus granulosus WW domain containing oxidoreductase 0.0009 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium ulcerans oxidoreductase 0.0009 0.0006 0.0024
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0009 0.0006 0.0004
Brugia malayi Ets-domain containing protein 0.0034 0.0376 0.0573
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0031 0.0335 0.0335
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0065 0.0851 0.1231
Leishmania major DNA polymerase eta, putative 0.0021 0.0182 0.0272
Loa Loa (eye worm) hypothetical protein 0.004 0.0466 0.0711
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0079 0.2347
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0009 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0026 0.0259 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0031 0.0335 0.0511
Echinococcus granulosus allatostatin A receptor 0.0032 0.0346 0.0501
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0346 0.0501
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.0006 0.0004
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0346 0.0346
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.022 0.0318
Trichomonas vaginalis ap endonuclease, putative 0.0026 0.0259 1
Echinococcus granulosus neuropeptide receptor 0.0032 0.0346 0.0501
Onchocerca volvulus 0.0032 0.0346 0.0877
Echinococcus multilocularis GTP binding nuclear protein Ran 0.001 0.0018 0.0018
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0009 0.0006 0.0246
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0036 0.0404 0.6461
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0335 0.0511
Mycobacterium ulcerans short-chain type oxidoreductase 0.0009 0.0006 0.0024
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0346 0.0346
Mycobacterium ulcerans thioesterase 0.0028 0.0289 0.2984
Loa Loa (eye worm) MH2 domain-containing protein 0.0056 0.0704 0.1075
Schistosoma mansoni carbonyl reductase 0.0009 0.0006 0.0009
Toxoplasma gondii type I fatty acid synthase, putative 0.0024 0.0227 0.2398
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0027 0.024
Brugia malayi hypothetical protein 0.0032 0.0346 0.0528
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.0346 0.0501
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0009 0.0006 0.0067
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0346 0.0346
Echinococcus multilocularis flap endonuclease 1 0.0012 0.0051 0.0051
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0346 0.0346
Onchocerca volvulus 0.0032 0.0346 0.0877
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0221 0.3186 0.4862
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.022 0.6495
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0009 0.0006 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0346 0.0501
Mycobacterium tuberculosis Possible oxidoreductase 0.0009 0.0006 0.0024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0026 0.0259 0.7684
Schistosoma mansoni amine GPCR 0.0032 0.0346 0.0501
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.022 0.6562
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0063 0.0823 0.1257
Loa Loa (eye worm) hypothetical protein 0.0023 0.022 0.0335
Brugia malayi Importin beta-1 subunit 0.0013 0.0071 0.0108
Echinococcus multilocularis vesicular acetylcholine transporter 0.0267 0.3882 0.3882
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0026 0.0259 0.0259
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0027 0.024
Loa Loa (eye worm) dehydrogenase 0.0009 0.0006 0.001
Brugia malayi Methyltransferase-like protein 4 0.001 0.0021 0.0032
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0009 0.0006 0.0024
Leishmania major GTP-binding protein, putative 0.001 0.0018 0.0021
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.0006 0.0004
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0011 0.0028 0.0923
Echinococcus granulosus hypothetical protein 0.0032 0.0346 0.0501
Loa Loa (eye worm) hypothetical protein 0.0182 0.2612 0.3986
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0346 0.0346
Brugia malayi G protein-coupled receptor 0.0032 0.0346 0.0528
Echinococcus granulosus single minded 2 0.0022 0.0195 0.0283
Loa Loa (eye worm) serotonin transporter b 0.0182 0.2612 0.3986
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0006 0.0024
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.0346 0.0528
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0072 0.0958 1
Brugia malayi Dopamine receptor 0.0032 0.0346 0.0528
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0009 0.0006 0.0024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0346 0.0346
Schistosoma mansoni neuropeptide receptor 0.0032 0.0346 0.0501
Loa Loa (eye worm) hypothetical protein 0.0013 0.0071 0.0108
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0009 0.0006 0.0004
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0027 0.024
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0084 0.2351
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0021 0.0654
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0335 0.0511
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0011 0.0028 0.1065
Schistosoma mansoni loxhd1 0.0023 0.022 0.0318
Echinococcus granulosus lamin dm0 0.0019 0.0153 0.0221
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0335 0.3528
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0009 0.0006 0.0004
Echinococcus granulosus hypothetical protein 0.0009 0.0006 0.0009
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0065 0.0851 0.0851
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.0006 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0026 0.0259 0.0389
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.0346 0.0501
Echinococcus granulosus somatostatin receptor 0.0032 0.0346 0.0501
Schistosoma mansoni carbonyl reductase 0.0009 0.0006 0.0009
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0182 0.0272
Giardia lamblia Hypothetical protein 0.0009 0.0006 0.0246
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.0006 0.0091
Loa Loa (eye worm) hypothetical protein 0.0031 0.0335 0.0511
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0335 0.0484
Schistosoma mansoni hypothetical protein 0.0032 0.0346 0.0501
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0373 0.0569
Entamoeba histolytica hypothetical protein 0.0011 0.0033 0.1122
Brugia malayi Doublecortin family protein 0.0023 0.022 0.0335
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.0006 0.0004
Brugia malayi ImpB/MucB/SamB family protein 0.0009 0.0004 0.0006
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0033 0.0373 0.5952
Echinococcus granulosus neuropeptide s receptor 0.0032 0.0346 0.0501
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus granulosus microtubule associated protein 2 0.0468 0.6909 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0026 0.0259 0.0389
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0186 0.7158
Brugia malayi Fli-1 protein 0.0102 0.1407 0.2148
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.0153 0.0233
Mycobacterium ulcerans Type I modular polyketide synthase 0.0033 0.0373 0.3864
Mycobacterium tuberculosis Conserved protein 0.001 0.0021 0.0175
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0011 0.0027 0.0338
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0081 0.0854
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.0346 0.0501
Brugia malayi hypothetical protein 0.0098 0.1348 0.2057
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0027 0.0334
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0039 0.0053
Echinococcus multilocularis somatostatin receptor 0.0032 0.0346 0.0346
Onchocerca volvulus 0.0032 0.0346 0.0877
Schistosoma mansoni hypothetical protein 0.0023 0.022 0.0318
Trichomonas vaginalis ap endonuclease, putative 0.0026 0.0259 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0147 0.0225
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0009 0.0006 0.0024
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0036 0.0404 0.6461
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0009 0.0006 0.0004
Onchocerca volvulus 0.0023 0.022 0.055
Schistosoma mansoni neuropeptide receptor 0.0032 0.0346 0.0501
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0017 0.0121 0.0175
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0009 0.0006 0.0006
Brugia malayi Dopamine receptor protein 2 0.0032 0.0346 0.0528
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.001 0.0018 0.0185
Trypanosoma cruzi short chain dehydrogenase, putative 0.0009 0.0006 0.0004
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0267 0.3882 1
Echinococcus granulosus g protein coupled receptor 0.0032 0.0346 0.0501
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0011 0.0033 0.1122
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0027 0.024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0009 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0949 1
Schistosoma mansoni steroid dehydrogenase 0.0009 0.0006 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0949 0.1373
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0039 0.1354
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.0346 0.0528
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0011 0.0033 0.1122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0346 0.0346
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0026 0.0259 0.267
Giardia lamblia Flap structure-specific endonuclease 0.0012 0.0051 0.1981
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0346 0.0346
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0079 0.2198
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.0067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Brugia malayi Retinol dehydrogenase 12 0.0009 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus multilocularis snurportin 1 0.0143 0.2023 0.2023
Entamoeba histolytica hypothetical protein 0.0017 0.0121 0.4584
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.0222
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Treponema pallidum sodium- and chloride- dependent transporter 0.0182 0.2612 1
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0009 0.0006 0.0024
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0009 0.0006 0.0004
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.0346 0.0501
Loa Loa (eye worm) hypothetical protein 0.0021 0.0182 0.0278
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Echinococcus granulosus sex peptide receptor 0.0032 0.0346 0.0501
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0026 0.0259 1
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0006 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0027 0.024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0346 0.0346
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0011 0.0028 0.004
Onchocerca volvulus 0.0019 0.0153 0.0377
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0009 0.0006 0.0024
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0346 0.0346
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0346 0.0346
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0033 0.0373 0.5952
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0011 0.0028 0.0028
Leishmania major cytochrome p450-like protein 0.0011 0.0027 0.0035
Echinococcus multilocularis importin subunit beta 1 0.0013 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0018 0.0145 0.021
Schistosoma mansoni hypothetical protein 0.0032 0.0346 0.0501
Plasmodium falciparum eukaryotic initiation factor 4A 0.0011 0.0028 0.0823
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0012 0.0051 0.0072
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0027 0.024
Loa Loa (eye worm) transcription factor SMAD2 0.0056 0.0704 0.1075
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.0346 0.0528
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0346 0.0501
Schistosoma mansoni hypothetical protein 0.0011 0.0027 0.0039
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0009 0.0006 0.0004
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0009 0.0006 0.0004
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0027 0.0035
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0009 0.0006 0.0024
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.0346 0.0501
Leishmania major eukaryotic initiation factor 4a, putative 0.0011 0.0028 0.0036
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0011 0.0028 0.004
Onchocerca volvulus 0.0032 0.0346 0.0877
Plasmodium vivax importin-beta 2, putative 0.0013 0.0071 0.1962
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0006 0.0004
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0009 0.0006 0.0004
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0006 0.0024
Leishmania major hypothetical protein, conserved 0.0009 0.0006 0.0004
Brugia malayi larval opioid receptor 0.0032 0.0346 0.0528
Schistosoma mansoni carbonyl reductase 0.0009 0.0006 0.0009
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0028 0.0289 0.4588
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Schistosoma mansoni opsin-like receptor 0.0032 0.0346 0.0501
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus multilocularis dna polymerase kappa 0.0009 0.0004 0.0004
Loa Loa (eye worm) doublecortin family protein 0.0023 0.022 0.0335
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0009 0.0006 0.019
Loa Loa (eye worm) hypothetical protein 0.0221 0.3186 0.4862
Leishmania major short chain dehydrogenase/reductase, putative 0.0009 0.0006 0.0004
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0009 0.0006 0.0067
Loa Loa (eye worm) oxidoreductase 0.0009 0.0006 0.001
Loa Loa (eye worm) intermediate filament protein 0.0019 0.0153 0.0233
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0027 0.0035
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0009 0.0006 0.0067
Schistosoma mansoni steroid dehydrogenase 0.0009 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0009
Trypanosoma brucei importin beta-1 subunit, putative 0.0013 0.0071 0.0102
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0011 0.0028 0.0923
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.0346 0.0501
Leishmania major hypothetical protein, conserved 0.0009 0.0006 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0009 0.0006 0.0009
Loa Loa (eye worm) oxidoreductase 0.0009 0.0006 0.001
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0346 0.0346
Echinococcus multilocularis geminin 0.0119 0.1651 0.1651
Schistosoma mansoni sodium/chloride dependent transporter 0.0182 0.2612 0.378
Trypanosoma cruzi importin beta-1 subunit, putative 0.0011 0.0033 0.0044
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0346 0.0501
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0012 0.0051 0.0072
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0011 0.0028 0.0923
Loa Loa (eye worm) hypothetical protein 0.0058 0.0742 0.1132
Brugia malayi GnHR receptor homolog 0.0032 0.0346 0.0528
Schistosoma mansoni rab6-interacting 0.0023 0.022 0.0318
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0346 0.0501
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.0346 0.0501
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0346 0.0528
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0346 0.0346
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.022 0.0318
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0027 0.0274 0.2832
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0026 0.0259 0.267
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0009 0.0006 0.0006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0145 0.0145
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0335 0.0484
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0024 0.0231 0.2377
Brugia malayi hypothetical protein 0.0032 0.0346 0.0528
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0335 0.0511
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0346 0.0346
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0009 0.0006 0.0004
Schistosoma mansoni amine GPCR 0.0032 0.0346 0.0501
Echinococcus granulosus carbonyl reductase 1 0.0009 0.0006 0.0009
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0027 0.0035
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.0006 0.0091
Brugia malayi hypothetical protein 0.0032 0.0346 0.0528
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0346 0.0501
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Echinococcus granulosus geminin 0.0119 0.1651 0.2389
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0335 0.0511
Schistosoma mansoni ran 0.001 0.0018 0.0025
Schistosoma mansoni hypothetical protein 0.0119 0.1651 0.2389
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.0006 0.0024
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0145 0.0222
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.0067
Toxoplasma gondii hypothetical protein 0.0031 0.0335 0.3528
Loa Loa (eye worm) oxidoreductase 0.0009 0.0006 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0346 0.0501
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Schistosoma mansoni myosin xvIII 0.0032 0.0346 0.0501
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0006 0.0004
Echinococcus multilocularis steroid dehydrogenase 0.0009 0.0006 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0027 0.0041
Brugia malayi cytochrome P450 0.0011 0.0027 0.0041
Echinococcus granulosus retinol dehydrogenase 11 0.0009 0.0006 0.0009
Schistosoma mansoni steroid dehydrogenase 0.0009 0.0006 0.0009
Schistosoma mansoni amine GPCR 0.0032 0.0346 0.0501
Brugia malayi Muscleblind-like protein 0.0221 0.3186 0.4862
Schistosoma mansoni neuropeptide receptor 0.0032 0.0346 0.0501
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0182 0.2612 0.378
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0346 0.0501
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0022 0.0202 0.318
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0027 0.0274 0.2832
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0346 0.0346
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0346 0.0501
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0032 0.0357 0.3702
Mycobacterium ulcerans oxidoreductase 0.0009 0.0006 0.0024
Echinococcus multilocularis GPCR, family 2 0.0018 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0033 0.0373 0.3864
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.0958 0.0958
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0143 0.2023 0.3087
Echinococcus multilocularis RUN 0.0023 0.022 0.022
Mycobacterium leprae Polyketide synthase Pks13 0.005 0.0622 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0335 0.0484
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0346 0.0346
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0031 0.0335 0.0484
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0027 0.024
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.001 0.0018 0.034
Schistosoma mansoni cytochrome P450 0.0011 0.0027 0.0039
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0031 0.0335 0.0335
Schistosoma mansoni terminal deoxycytidyl transferase 0.0009 0.0004 0.0006
Loa Loa (eye worm) norepinephrine transporter 0.0182 0.2612 0.3986
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0072 0.0958 0.1462
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0033 0.0373 0.3864
Schistosoma mansoni DNA polymerase eta 0.0021 0.0182 0.0264
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0027 0.024
Schistosoma mansoni histamine h1 receptor 0.0032 0.0346 0.0501
Echinococcus granulosus RUN 0.0023 0.022 0.0318
Brugia malayi AKH receptor 0.0032 0.0346 0.0528
Schistosoma mansoni vesicular acetylcholine transporter 0.0267 0.3882 0.5618
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Mycobacterium ulcerans dehydrogenase 0.0009 0.0006 0.0024
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.0006 0.0091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.0143 0.2023 0.2928
Schistosoma mansoni steroid dehydrogenase 0.0009 0.0006 0.0009
Brugia malayi Dehydrogenases, short chain protein 30 0.0009 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0056 0.0715 0.1091
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0017 0.0123 0.1302
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0031 0.0335 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0145 0.0222
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0011 0.0028 0.0246
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0027 0.024
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.0346 0.0528
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.001 0.0018 0.0027
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0466 0.0711
Schistosoma mansoni polycystin 1-related 0.0023 0.022 0.0318
Schistosoma mansoni biogenic amine receptor 0.0032 0.0346 0.0501
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.00000000005964 0.00000000062873
Brugia malayi sulfakinin receptor protein 0.0032 0.0346 0.0528
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0027 0.024
Leishmania major dehydrogenase-like protein 0.0009 0.0006 0.0004
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.0006 0.0091
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.0006 0.0024
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.0006 0.0091
Schistosoma mansoni ran 0.001 0.0018 0.0025
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0031 0.0339 0.3517
Loa Loa (eye worm) cytochrome P450 0.0011 0.0027 0.0041
Plasmodium vivax RNA helicase-1, putative 0.0011 0.0028 0.0645
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0267 0.3882 0.5924
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0346 0.0501
Schistosoma mansoni steroid dehydrogenase 0.0009 0.0006 0.0009
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.022 0.022
Brugia malayi Ets-domain containing protein 0.0034 0.0376 0.0573
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0009 0.0006 0.0024
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0011 0.0028 0.0028
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0027 0.0041
Entamoeba histolytica Flap nuclease, putative 0.0012 0.0051 0.1853
Brugia malayi neuropeptide F receptor 0.0032 0.0346 0.0528
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0949 0.1373
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Onchocerca volvulus 0.0182 0.2612 0.6723
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0027 0.024
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0027 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.0013 0.0071 0.0102
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0346 0.0501
Brugia malayi hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0027 0.024
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0335 0.0511
Plasmodium falciparum steroid dehydrogenase, putative 0.0009 0.0006 0.019
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0027 0.0041
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0027 0.024
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.0346 0.0528
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0027 0.024
Onchocerca volvulus 0.0019 0.0153 0.0377
Echinococcus multilocularis oxidoreductase 0.0009 0.0006 0.0006
Onchocerca volvulus 0.0023 0.022 0.055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0346 0.0501
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0346 0.0346
Brugia malayi vesicular acetylcholine transporter unc-17 0.0267 0.3882 0.5924
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0335 0.0484
Loa Loa (eye worm) hypothetical protein 0.0182 0.2612 0.3986
Toxoplasma gondii carbonyl reductase 1, putative 0.0009 0.0006 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0027 0.024
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Brugia malayi Serotonin receptor 0.0032 0.0346 0.0528
Echinococcus granulosus vesicular acetylcholine transporter 0.0267 0.3882 0.5618
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0195 0.2005
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0346 0.0346
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0346 0.0346
Echinococcus granulosus snurportin 1 0.0143 0.2023 0.2928
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.0006 0.0091
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0072 0.0958 0.1456
Brugia malayi exodeoxyribonuclease III family protein 0.0026 0.0259 0.0395
Brugia malayi Flap endonuclease-1 0.0012 0.0051 0.0078
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Leishmania major hypothetical protein, conserved 0.0009 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.022 0.0335
Onchocerca volvulus 0.0032 0.0346 0.0877
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Giardia lamblia Reductase, putative 0.0009 0.0006 0.0246
Leishmania major short chain dehydrogenase/reductase, putative 0.0009 0.0006 0.0004
Schistosoma mansoni steroid dehydrogenase 0.0009 0.0006 0.0009
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0011 0.0028 0.0036
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Toxoplasma gondii HEAT repeat-containing protein 0.0013 0.0071 0.0746
Onchocerca volvulus 0.0032 0.0346 0.0877
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0346 0.0501
Leishmania major 3-keto-dihydrosphingosine reductase 0.0009 0.0006 0.0004
Echinococcus granulosus neuropeptide receptor 0.0032 0.0346 0.0501
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0009 0.0006 0.0006
Mycobacterium tuberculosis Hypothetical protein 0.001 0.0021 0.0175
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0009 0.0006 0.001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Schistosoma mansoni hypothetical protein 0.0032 0.0346 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0346 0.0501
Schistosoma mansoni hypothetical protein 0.0017 0.0121 0.0175
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Schistosoma mansoni biogenic amine receptor 0.0032 0.0346 0.0501
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0153 0.0233
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0011 0.0028 0.004
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0027 0.0035
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.0346 0.0528
Mycobacterium ulcerans short-chain dehydrogenase 0.0011 0.0038 0.0352
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0335 0.0484
Trichomonas vaginalis importin beta-1, putative 0.0011 0.0033 0.1122
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0027 0.024
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Loa Loa (eye worm) oxidoreductase 0.0009 0.0006 0.001
Schistosoma mansoni steroid dehydrogenase 0.0009 0.0006 0.0009
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0346 0.0501
Brugia malayi ORL1-like opioid receptor 0.0032 0.0346 0.0528
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0027 0.024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0346 0.0501
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Loa Loa (eye worm) oxidoreductase 0.0009 0.0006 0.001
Leishmania major cytochrome p450-like protein 0.0011 0.0027 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0949 0.9905
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.0006 0.0006
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0027 0.024
Loa Loa (eye worm) hypothetical protein 0.0182 0.2612 0.3986
Brugia malayi RNA, U transporter 1 0.0038 0.0443 0.0676
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0335 0.0511
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0022 0.0196 0.2063
Leishmania major oxidoreductase-like protein 0.0009 0.0006 0.0004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0027 0.0284
Onchocerca volvulus 0.0058 0.0745 0.1907
Loa Loa (eye worm) flap endonuclease-1 0.0012 0.0051 0.0078
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0346 0.0346
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0031 0.0335 0.0335
Echinococcus multilocularis dna polymerase eta 0.0021 0.0182 0.0182
Echinococcus multilocularis serotonin receptor 0.0032 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.0018 0.0145 0.021
Brugia malayi AMP-binding enzyme family protein 0.001 0.0024 0.0036
Onchocerca volvulus 0.007 0.0926 0.2374
Schistosoma mansoni intermediate filament proteins 0.0019 0.0153 0.0221
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0009 0.0004 0.0006
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0009 0.0006 0.0091
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0346 0.0501
Trichomonas vaginalis flap endonuclease-1, putative 0.0012 0.0051 0.1853
Onchocerca volvulus 0.0032 0.0346 0.0877
Brugia malayi putative neuropeptide receptor 0.0032 0.0346 0.0528
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.0006 0.0024
Mycobacterium ulcerans polyketide synthase Pks13 0.005 0.0622 0.6475
Onchocerca volvulus 0.0013 0.0057 0.0131
Leishmania major short chain dehydrogenase, putative 0.0009 0.0006 0.0004
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0009 0.0006 0.0004
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0011 0.0028 0.029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0346 0.0501
Echinococcus granulosus serotonin receptor 0.0032 0.0346 0.0501
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0027 0.024
Schistosoma mansoni flap endonuclease-1 0.0011 0.0034 0.0049
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0346 0.0501
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0335 0.0335
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.012 0.0173
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0335 0.0484
Echinococcus granulosus g protein coupled receptor 0.0032 0.0346 0.0501
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0006 0.0004
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0027 0.0035
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0031 0.0339 0.0518
Brugia malayi bHLH-PAS transcription factor 0.0022 0.0195 0.0298
Toxoplasma gondii exonuclease III APE 0.0026 0.0259 0.2726
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.6552 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0346 0.0501
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0011 0.0028 0.0923
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.0346 0.0528
Trichomonas vaginalis steroid dehydrogenase, putative 0.0009 0.0006 0.0091
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.0067
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0346 0.0346
Mycobacterium ulcerans Type I modular polyketide synthase 0.0033 0.0373 0.3864
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0346 0.0346
Echinococcus granulosus oxidoreductase 0.0009 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0018 0.0145 0.021
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0346 0.0346
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0949 0.9905
Giardia lamblia Short-chain dehydrogenase, putative 0.0009 0.0006 0.0246
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus multilocularis lamin 0.0019 0.0153 0.0153
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.0958 0.1386
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0346 0.0501
Echinococcus granulosus flap endonuclease 1 0.0012 0.0051 0.0074
Brugia malayi hypothetical protein 0.0023 0.022 0.0335
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0346 0.0346
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0346 0.0501
Schistosoma mansoni neuropeptide receptor 0.0032 0.0346 0.0501
Loa Loa (eye worm) hypothetical protein 0.0011 0.0028 0.0042
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0072 0.0958 0.1386
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0186 0.0284
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0027 0.024
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.001 0.0018 0.0027
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0009 0.0006 0.001
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0027 0.024
Schistosoma mansoni hypothetical protein 0.004 0.0466 0.0674
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0346 0.0501
Echinococcus granulosus muscleblind protein 0.0221 0.3186 0.4611
Brugia malayi RE15519p 0.0032 0.0346 0.0528
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0346 0.0501
Toxoplasma gondii hypothetical protein 0.0031 0.0335 0.3528
Echinococcus multilocularis musashi 0.0019 0.0153 0.0153
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0009 0.0006 0.0004
Onchocerca volvulus 0.0032 0.0346 0.0877
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.0006 0.0004
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0346 0.0501
Schistosoma mansoni hypothetical protein 0.0119 0.1651 0.2389
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0335 0.3528
Echinococcus granulosus GTP binding nuclear protein Ran 0.001 0.0018 0.0025
Brugia malayi G-protein coupled receptor 0.0032 0.0346 0.0528
Brugia malayi Cytochrome P450 family protein 0.0011 0.0027 0.0041
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.005 0.0622 0.6475
Entamoeba histolytica hypothetical protein 0.0009 0.0006 0.0091
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.022 0.022
Loa Loa (eye worm) oxidoreductase 0.0009 0.0006 0.001
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.0006 0.0091
Mycobacterium tuberculosis Possible oxidoreductase 0.0009 0.0006 0.0024
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.0006 0.0024
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.0006 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0026 0.0259 0.0894
Mycobacterium ulcerans dehydrogenase/reductase 0.0009 0.0006 0.0024
Entamoeba histolytica hypothetical protein 0.0017 0.0121 0.4584
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.0006 0.0004
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.001 0.0018 0.0523
Schistosoma mansoni lamin 0.0019 0.0153 0.0221
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Plasmodium vivax amine transporter, putative 0.0031 0.0335 1
Loa Loa (eye worm) dehydrogenase 0.0009 0.0006 0.001
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0009 0.0006 0.0004
Brugia malayi hypoxia-induced factor 1 0.0091 0.1233 0.1882
Leishmania major hypothetical protein, conserved 0.001 0.0021 0.0025
Echinococcus granulosus hypothetical protein 0.0009 0.0006 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0346 0.0501
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0346 0.0346
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0032 0.0357 0.3702
Echinococcus granulosus steroid dehydrogenase 0.0009 0.0006 0.0009
Echinococcus multilocularis sex peptide receptor 0.0032 0.0346 0.0346
Onchocerca volvulus 0.0032 0.0346 0.0877
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0335 0.0484
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Brugia malayi hypothetical protein 0.0032 0.0346 0.0528
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0346 0.0501
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0335 0.3528
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0346 0.0501
Toxoplasma gondii oxidoreductase, putative 0.0009 0.0006 0.0067
Schistosoma mansoni ap endonuclease 0.0026 0.0259 0.0374
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.0346 0.0501
Brugia malayi hypothetical protein 0.0032 0.0346 0.0528
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0148 0.4415
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.0006 0.0004
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0012 0.0051 0.054
Schistosoma mansoni amine GPCR 0.0032 0.0346 0.0501
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Echinococcus granulosus lamin 0.0019 0.0153 0.0221
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0346 0.0346
Brugia malayi hypothetical protein 0.0023 0.022 0.0335
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Plasmodium falciparum importin beta, putative 0.0013 0.0071 0.2115
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0335 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0033 0.0373 0.0569
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0346 0.0501
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.0006 0.0004
Echinococcus granulosus intermediate filament protein 0.0019 0.0153 0.0221
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Onchocerca volvulus Neuropeptide F receptor homolog 0.0032 0.0346 0.0877
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0006 0.0004
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0027 0.024
Mycobacterium tuberculosis Polyketide synthase Pks13 0.005 0.0622 0.6475
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0027 0.024
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0009 0.0006 0.0004
Onchocerca volvulus 0.0031 0.0335 0.0847
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0027 0.024
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.0006 0.0004
Schistosoma mansoni retinal dehydrogenase 0.0009 0.0006 0.0009
Entamoeba histolytica hypothetical protein 0.0017 0.0121 0.4584
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0027 0.024
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0027 0.0281 0.2902
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Loa Loa (eye worm) hypothetical protein 0.0031 0.0335 0.0511
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.0006 0.0091
Brugia malayi Cytochrome P450 family protein 0.0034 0.0373 0.0569
Mycobacterium ulcerans polyketide synthase MbtD 0.001 0.0024 0.0207
Mycobacterium ulcerans polyketide synthase 0.0033 0.0373 0.3864
Onchocerca volvulus 0.0032 0.0346 0.0877
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0027 0.024
Mycobacterium ulcerans polyketide synthase Pks9 0.0022 0.0202 0.2076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0145 0.021
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0009 0.0006 0.0024
Loa Loa (eye worm) acyl carrier protein 0.0015 0.0101 0.0153
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.001 0.0018 0.0021
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0009 0.0006 0.0024
Echinococcus multilocularis muscleblind protein 0.0221 0.3186 0.3186
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0742 0.1132
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.0346 0.0528
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0036 0.0404 0.4192
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0949 0.9905
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.0346 0.0528
Echinococcus multilocularis transient receptor potential cation channel 0.0009 0.0006 0.0006
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0039 0.1354
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0009 0.0006 0.0091
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Schistosoma mansoni opsin-like receptor 0.0032 0.0346 0.0501
Brugia malayi eukaryotic initiation factor 4A 0.0011 0.0028 0.0042
Giardia lamblia Methyltransferase like 2 0.001 0.0021 0.0801
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0011 0.0028 0.0036
Entamoeba histolytica hypothetical protein 0.0017 0.0121 0.4584
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0089 0.013
Schistosoma mansoni hypothetical protein 0.0018 0.0145 0.021
Echinococcus granulosus retinol dehydrogenase 11 0.0009 0.0006 0.0009
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0012 0.0042 0.0399
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium leprae putative cytochrome p450 0.0011 0.0027 0.0334
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0346 0.0528
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.0006 0.0004
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0346 0.0501
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0009 0.0006 0.0004
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0036 0.0404 0.4192
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.001 0.0024 0.0207
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.6552 1
Schistosoma mansoni ets-related 0.0102 0.1407 0.2037
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0335 0.0484
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.0067
Trypanosoma cruzi short chain dehydrogenase, putative 0.0009 0.0006 0.0004
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0036 0.0404 0.4192
Onchocerca volvulus 0.0032 0.0346 0.0877
Schistosoma mansoni rab6-interacting 0.0023 0.022 0.0318
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0346 0.0501
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0182 0.0278
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0182 0.2612 0.3986
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.0346 0.0528
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0027 0.024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.0346 0.0528
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.0958 1
Echinococcus granulosus dna polymerase kappa 0.0009 0.0004 0.0006
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0006 0.0024
Loa Loa (eye worm) oxidoreductase 0.0009 0.0006 0.001
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0009 0.0006 0.0024
Plasmodium vivax flap endonuclease 1, putative 0.0012 0.0051 0.1367
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.0006 0.0006
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0015 0.0089 0.094
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0011 0.0028 0.0055
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.0346 0.0501
Echinococcus multilocularis retinol dehydrogenase 13 0.0009 0.0006 0.0006
Loa Loa (eye worm) solute carrier family 6 member 4 0.0182 0.2612 0.3986
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0335 0.0511
Loa Loa (eye worm) hypothetical protein 0.0227 0.3285 0.5013
Brugia malayi neuropeptide F receptor 0.0032 0.0346 0.0528
Echinococcus multilocularis lamin dm0 0.0019 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0019 0.0151 0.0231
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0742 0.1132
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0346 0.0346
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Mycobacterium ulcerans fatty acid synthase Fas 0.0011 0.0027 0.0243
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0009 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0031 0.0335 0.0511
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Brugia malayi intermediate filament protein 0.0019 0.0153 0.0233
Trypanosoma brucei oxidoreductase-like protein 0.0009 0.0006 0.0004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.001 0.0018 0.0021
Loa Loa (eye worm) fatty acid synthase 0.0033 0.0366 0.0558
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Schistosoma mansoni aryl hydrocarbon receptor 0.0029 0.031 0.0448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0346 0.0501
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0335 0.0484
Echinococcus granulosus dna polymerase eta 0.0021 0.0182 0.0264
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0009 0.0006 0.001
Echinococcus granulosus carbonyl reductase 1 0.0009 0.0006 0.0009
Schistosoma mansoni ap endonuclease 0.0026 0.0259 0.0374
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.0006 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Brugia malayi Serotonin receptor 0.0032 0.0346 0.0528
Schistosoma mansoni importin beta-1 0.0013 0.0071 0.0102
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.0006 0.0091
Plasmodium falciparum amino acid transporter, putative 0.0031 0.0335 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.001 0.0018 0.0677
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0027 0.024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Brugia malayi hypothetical protein 0.007 0.0926 0.1414
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0036 0.0404 0.4192
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0026 0.0259 0.0389
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Schistosoma mansoni amine GPCR 0.0032 0.0346 0.0501
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0034 0.0376 0.0573
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.082 0.1252
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0027 0.0274 0.4353
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0346 0.0501
Brugia malayi hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0346 0.0501
Schistosoma mansoni steroid dehydrogenase 0.0009 0.0006 0.0009
Loa Loa (eye worm) hypoxia-induced factor 1 0.0091 0.1233 0.1882
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0027 0.024
Brugia malayi cytoplasmic intermediate filament protein 0.001 0.0021 0.0032
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0186 0.0186
Brugia malayi hypothetical protein 0.0009 0.0006 0.001
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.0346 0.0501
Brugia malayi oxidoreductase 0.0009 0.0006 0.001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0949 0.0949
Echinococcus multilocularis microtubule associated protein 2 0.0468 0.6909 0.6909
Loa Loa (eye worm) hypothetical protein 0.0031 0.0335 0.0511
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0346 0.0501
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0009 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0098 0.1348 0.2057
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0039 0.0053
Leishmania major short chain dehydrogenase-like protein 0.0009 0.0006 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0006 0.0004
Echinococcus granulosus serotonin transporter 0.0182 0.2612 0.378
Echinococcus multilocularis retinol dehydrogenase 11 0.0009 0.0006 0.0006
Onchocerca volvulus 0.0031 0.0335 0.0847
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0528
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0346 0.0501
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0186 0.7158
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0009 0.0006 0.0009
Brugia malayi Cytochrome P450 family protein 0.0011 0.0027 0.0041
Echinococcus granulosus carbonyl reductase 1 0.0009 0.0006 0.0009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0346 0.0346
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0346 0.0346
Brugia malayi dehydrogenases, short chain protein 2 0.0009 0.0006 0.001
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0032 0.0346 0.0877
Leishmania major hypothetical protein, conserved 0.0009 0.0006 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0027 0.024
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Brugia malayi MH2 domain containing protein 0.0056 0.0704 0.1075
Echinococcus granulosus GPCR family 2 0.0018 0.0145 0.021
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0335 0.0484
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Schistosoma mansoni steroid dehydrogenase 0.0009 0.0006 0.0009
Trichomonas vaginalis ran, putative 0.001 0.0018 0.0529
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0346 0.0346
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0009 0.0006 0.0091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0742 0.1132
Schistosoma mansoni methyltransferase-related 0.001 0.0021 0.003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0145 0.0145
Brugia malayi Melatonin receptor type 1A 0.0032 0.0346 0.0528
Brugia malayi G-protein coupled receptor 0.0032 0.0346 0.0528
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0017 0.0121 0.0121
Schistosoma mansoni short chain dehydrogenase 0.0009 0.0006 0.0009
Brugia malayi hypothetical protein 0.0032 0.0346 0.0528
Brugia malayi hypothetical protein 0.0032 0.0346 0.0528
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0949 0.1442
Schistosoma mansoni steroid dehydrogenase 0.0009 0.0006 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0145 0.021
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.0006 0.0006
Brugia malayi hypothetical protein 0.0009 0.0006 0.001
Loa Loa (eye worm) oxidoreductase 0.0009 0.0006 0.001
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0027 0.024
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.0346 0.0528
Brugia malayi Dehydrogenases, short chain protein 2 0.0009 0.0006 0.001
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.0006 0.0006
Onchocerca volvulus 0.0031 0.0335 0.0847
Onchocerca volvulus 0.0032 0.0346 0.0877
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0335 0.0511
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0009 0.0006 0.0024
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.0006 0.0091
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0009 0.0006 0.0091
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0346 0.0346
Schistosoma mansoni opsin-like receptor 0.0032 0.0346 0.0501
Brugia malayi hypothetical protein 0.0032 0.0346 0.0528
Onchocerca volvulus 0.0022 0.0195 0.0487
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0009 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0006 0.0024
Toxoplasma gondii type I fatty acid synthase, putative 0.0036 0.0404 0.4257
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0346 0.0528
Plasmodium falciparum transporter, putative 0.0031 0.0335 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0346 0.0501
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0027 0.024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.001
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0.0027 0.024
Leishmania major importin beta-1 subunit, putative 0.0011 0.0033 0.0044
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0346 0.0346
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0949 0.1373
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0009 0.0006 0.0004
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0006 0.0067
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0346 0.0501
Echinococcus multilocularis steroid dehydrogenase 0.0009 0.0006 0.0006
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0039 0.0053
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.6552 1
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0009 0.0006 0.0009
Leishmania major cytochrome p450-like protein 0.0011 0.0027 0.0035
Mycobacterium tuberculosis Probable dehydrogenase 0.0009 0.0006 0.0024
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0346 0.0346
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0346 0.0346
Onchocerca volvulus 0.0032 0.0346 0.0877
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0335 0.0484
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.001
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0027 0.024
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.0006 0.0024
Echinococcus granulosus fmrfamide receptor 0.0032 0.0346 0.0501
Echinococcus multilocularis transfer RNA-Lys 0.0022 0.0195 0.0195

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 4.95 nM Sigma 2 binding assay was done rat liver membrane,by labelling the binding site with [3H]-DTG (DuPont-NEN) in the presence of [3H]-(+)-pentazocine (100 nM) ChEMBL. 9397171
Ki (binding) = 10.3 nM Binding to vesicular acetylcholine transporter of torpedo synaptic vesicles ChEMBL. 9397171
Ki (binding) = 10.3 nM Binding to vesicular acetylcholine transporter of torpedo synaptic vesicles ChEMBL. 9397171
Ki (binding) = 30.89 nM Sigma-1 binding assay was done in guinea pig membranes by labelling the binding site with [3H]-(+)-pentazocine ChEMBL. 9397171
Ki (binding) = 30.89 nM Sigma-1 binding assay was done in guinea pig membranes by labelling the binding site with [3H]-(+)-pentazocine ChEMBL. 9397171
Ki (binding) = 234 nM Binding affinity of the compound for serotonin transporter was determined in rat cortical membrane ChEMBL. 9397171
Ki (binding) = 234 nM Binding affinity of the compound for serotonin transporter was determined in rat cortical membrane ChEMBL. 9397171
Ki (binding) = 306 nM Binding affinity of the compound for dopamine transporter was determined in rat striatal membrane ChEMBL. 9397171
Ki (binding) = 306 nM Binding affinity of the compound for dopamine transporter was determined in rat striatal membrane ChEMBL. 9397171
Ki (binding) = 1490 nM In vitro binding affinity for D2/D3 receptors in rat striatal homogenates by [125I]-NCQ298 displacement. ChEMBL. 9397171

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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