pI: 8.6125 |
Length (AA): 553 |
MW (Da): 62802 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 44 | 2ov2 (I) | 10 | 43 | 56.00 | 0.0000034 | 0.6 | 0.583483 | 0.78 |
11 | 44 | 2odb (B) | 11 | 44 | 56.00 | 0.0000045 | 0.49 | 0.588483 | 0.62 |
15 | 61 | 1f3m (A) | 78 | 128 | 40.00 | 0 | 0.58 | 0.520291 | -0.93 |
133 | 533 | 3v5w (A) | 44 | 455 | 21.00 | 0 | 1 | 0.929436 | 0.17 |
252 | 548 | 4xbr (A) | 193 | 589 | 65.00 | 0 | 1 | 1.33907 | -0.72 |
259 | 545 | 4ks7 (A) | 386 | 672 | 62.00 | 0 | 1 | 1.19939 | -1.1 |
259 | 549 | 3fxz (A) | 249 | 539 | 48.00 | 0 | 1 | 1.06262 | -1.06 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131977)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_15470 | serine/threonine-protein kinase PAK 7 |
Caenorhabditis elegans | CELE_C45B11.1 | Protein PAK-2, isoform B |
Drosophila melanogaster | Dmel_CG18582 | mushroom bodies tiny |
Echinococcus granulosus | EgrG_000857800 | serine:threonine protein kinase PAK 4 |
Echinococcus multilocularis | EmuJ_000857800 | serine:threonine protein kinase PAK 4 |
Homo sapiens | ENSG00000101349 | p21 protein (Cdc42/Rac)-activated kinase 7 |
Homo sapiens | ENSG00000130669 | p21 protein (Cdc42/Rac)-activated kinase 4 |
Loa Loa (eye worm) | LOAG_03732 | STE/STE20/PAKB protein kinase |
Mus musculus | ENSMUSG00000030602 | p21 protein (Cdc42/Rac)-activated kinase 4 |
Mus musculus | ENSMUSG00000039913 | p21 protein (Cdc42/Rac)-activated kinase 7 |
Schmidtea mediterranea | mk4.021809.00 | |
Schmidtea mediterranea | mk4.010637.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 4 | Compounds | References |
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 7 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 27.1% | 280 aa | Compounds | References |
Rattus norvegicus | MAP kinase p38 alpha | 360 aa | 24.1% | 295 aa | Compounds | References |
Sus scrofa | Glycogen synthase kinase 3 beta | 420 aa | 25.5% | 364 aa | Compounds | References |
Rattus norvegicus | Serine/threonine-protein kinase pim-3 | 326 aa | 26.4% | 261 aa | Compounds | References |
Bos taurus | Glycogen synthase kinase-3 beta splice variant X1 | 419 aa | 25.5% | 364 aa | Compounds | References |
Rattus norvegicus | Glycogen synthase kinase-3 beta | 420 aa | 25.5% | 364 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 25.5% | 286 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 23.2% | 284 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 23.9% | 285 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 29.7% | 158 aa | Compounds | References |