Detailed information for compound 140803

Basic information

Technical information
  • TDR Targets ID: 140803
  • Name: 6-cyano-3-hydroxy-N,2,2-trimethyl-3,4-dihydro chromene-4-carbothioamide
  • MW: 276.354 | Formula: C14H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 1.57 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/N=C(/C1c2cc(C#N)ccc2OC(C1O)(C)C)\S
  • InChi: 1S/C14H16N2O2S/c1-14(2)12(17)11(13(19)16-3)9-6-8(7-15)4-5-10(9)18-14/h4-6,11-12,17H,1-3H3,(H,16,19)
  • InChiKey: HWRIRDKUICPDGI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-cyano-3-hydroxy-N,2,2-trimethyl-chromane-4-carbothioamide
  • 6-cyano-3-hydroxy-N,2,2-trimethyl-3,4-dihydro-2H-1-benzopyran-4-carbothioamide
  • 6-cyano-3-hydroxy-N,2,2-trimethyl-chroman-4-carbothioamide
  • 6-cyano-3-hydroxy-N,2,2-trimethylchroman-4-carbothioamide
  • 6-cyano-3-hydroxy-N,2,2-trimethyl-4-chromancarbothioamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0031 0.0042 0.0151
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Schistosoma mansoni Smad4 0.0016 0.0006 0.0008
Brugia malayi PHD-finger family protein 0.003 0.004 0.0156
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0053 0.167
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0067 0.0127 0.2957
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.017 0.5689
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0067 0.0127 0.2957
Brugia malayi cytochrome P450 0.0067 0.0127 0.051
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0093 0.019 0.4492
Echinococcus multilocularis carbonyl reductase 1 0.0031 0.0042 0.0037
Onchocerca volvulus Cell death protein 3 homolog 0.0283 0.0643 0.5414
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0018 0.0011 0.0035
Schistosoma mansoni microtubule-associated protein tau 0.0722 0.1689 1
Onchocerca volvulus 0.002 0.0017 0.01
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.0137 0.3212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0232
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0088 0.0495
Onchocerca volvulus 0.0016 0.0007 0.0017
Plasmodium falciparum metacaspase 1 0.0135 0.029 1
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1336 0.3153 1
Schistosoma mansoni hypothetical protein 0.0356 0.0817 0.4822
Brugia malayi Cell death protein 3 precursor 0.0283 0.0643 0.2619
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0031 0.0042 0.0314
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0031 0.0042 0.0897
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0007 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0125 0.0267 0.107
Schistosoma mansoni aldehyde dehydrogenase 0.0326 0.0747 0.4403
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0135 0.029 0.3849
Schistosoma mansoni hypothetical protein 0.003 0.004 0.021
Brugia malayi ecdysteroid receptor 0.0095 0.0196 0.0792
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Trypanosoma cruzi metacaspase 5, putative 0.0135 0.029 0.6925
Loa Loa (eye worm) hypothetical protein 0.0095 0.0196 0.0781
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0053 0.1157
Brugia malayi steroid hormone receptor 0.0095 0.0196 0.0792
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0341
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.017 0.5781
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0031 0.0042 0.022
Brugia malayi Ets-domain containing protein 0.0071 0.0138 0.0553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0031 0.0042 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Brugia malayi Cytochrome P450 family protein 0.0067 0.0127 0.051
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0018 0.0011 0.0147
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.0017 0.007
Onchocerca volvulus 0.0045 0.0076 0.0599
Mycobacterium tuberculosis Probable esterase LipL 0.0188 0.0417 0.1323
Schistosoma mansoni caspase-7 (C14 family) 0.0283 0.0643 0.3786
Trypanosoma brucei short-chain dehydrogenase, putative 0.0031 0.0042 0.0897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0094 0.1193
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0067 0.0127 0.0387
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0031 0.0042 0.0314
Echinococcus multilocularis retinol dehydrogenase 11 0.0031 0.0042 0.0037
Brugia malayi photoreceptor-specific nuclear receptor 0.0095 0.0196 0.0792
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0031 0.0042 0.0133
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0067 0.0127 0.0387
Echinococcus granulosus caspase 3 0.0196 0.0437 0.1766
Echinococcus multilocularis protein dispatched 1 0.005 0.0089 0.0084
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0076 0.0599
Brugia malayi Dehydrogenases, short chain protein 30 0.0031 0.0042 0.0163
Echinococcus multilocularis transient receptor potential cation channel 0.0031 0.0042 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0056 0.03
Echinococcus multilocularis thyroid hormone receptor alpha 0.0095 0.0196 0.0191
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0005 0.0016
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0326 0.0747 0.0742
Onchocerca volvulus 0.0152 0.033 0.2761
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0007 0.0017
Loa Loa (eye worm) oxidoreductase 0.0031 0.0042 0.0151
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.005 0.0088 0.0083
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0076 0.0071
Brugia malayi hypothetical protein 0.104 0.2448 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0031 0.0042 0.1295
Onchocerca volvulus 0.002 0.0017 0.01
Brugia malayi Steroid receptor seven-up type 2 0.0095 0.0196 0.0792
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0116 0.2687
Plasmodium vivax hypothetical protein, conserved 0.0135 0.029 0.6925
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0117 0.0459
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0031 0.0042 0.0897
Leishmania major cathepsin L-like protease 0.0062 0.0116 0.1494
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0056 0.0051
Echinococcus granulosus retinol dehydrogenase 11 0.0031 0.0042 0.0151
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Onchocerca volvulus 0.0031 0.0042 0.0314
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0011 0.0036
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0017 0.01
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0133
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0067 0.0127 0.0403
Entamoeba histolytica hypothetical protein 0.0114 0.0241 0.8254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Trypanosoma brucei short-chain dehydrogenase, putative 0.0031 0.0042 0.0897
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0067 0.0127 0.0403
Brugia malayi Pre-SET motif family protein 0.0064 0.0121 0.0487
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0095 0.0196 0.1619
Echinococcus granulosus carbonyl reductase 1 0.0031 0.0042 0.0151
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0095 0.0196 0.1132
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0045 0.0077 0.0606
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.019 0.1572
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.004 0.0477
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0018 0.0011 0.0025
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Schistosoma mansoni smad 0.0016 0.0006 0.0008
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0031 0.0042 0.0151
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0053 0.0405
Trichomonas vaginalis glucosylceramidase, putative 0.0161 0.0353 0.2957
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.0448 0.1822
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0067 0.0127 0.0403
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.0296 0.1201
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0138 0.0132
Leishmania major cathepsin L-like protease 0.0062 0.0116 0.1494
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Echinococcus granulosus cytochrome P450 2K1 0.0067 0.0127 0.0499
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0031 0.0042 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0374 0.3133
Loa Loa (eye worm) hypothetical protein 0.0095 0.0196 0.0781
Loa Loa (eye worm) dehydrogenase 0.0031 0.0042 0.0151
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0018 0.0011 0.0082
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0095 0.0196 0.1132
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.029 0.2423
Trypanosoma brucei metacaspase MCA3 0.0135 0.029 0.6925
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0135 0.0291 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0058 0.1286
Schistosoma mansoni hypothetical protein 0.0212 0.0474 0.2785
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.0417 0.35
Onchocerca volvulus Huntingtin homolog 0.0264 0.0597 0.5026
Mycobacterium leprae Conserved hypothetical protein 0.0067 0.0127 0.0387
Onchocerca volvulus 0.0053 0.0094 0.0751
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0058 0.1286
Mycobacterium leprae putative cytochrome p450 0.0067 0.0127 0.0387
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Onchocerca volvulus 0.0031 0.0042 0.0314
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0135 0.0291 0.1169
Mycobacterium ulcerans oxidoreductase 0.0031 0.0042 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.0161 0.0353 0.2957
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Loa Loa (eye worm) hypothetical protein 0.0064 0.0121 0.0476
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0007 0.0068
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0067 0.0127 0.0403
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0499
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0018 0.0011 0.0082
Toxoplasma gondii ABC1 family protein 0.0188 0.0417 0.5559
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Loa Loa (eye worm) Smad1 0.0016 0.0006 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0067 0.0127 0.0403
Leishmania major short chain dehydrogenase/reductase, putative 0.0031 0.0042 0.0499
Onchocerca volvulus 0.0031 0.0042 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0077 0.0606
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0065 0.0508
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0332 0.0759 0.0754
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0225 0.0505 0.1586
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0095 0.0196 0.0781
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0017
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0194 0.0431 0.1743
Mycobacterium ulcerans short-chain type oxidoreductase 0.0031 0.0042 0.0117
Brugia malayi nuclear receptor NHR-88 0.0045 0.0076 0.03
Echinococcus granulosus guanine nucleotide binding protein G protein 0.002 0.0017 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0095 0.0196 0.0792
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0067 0.0127 0.0387
Echinococcus granulosus smad 0.0016 0.0006 0.0005
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0135 0.0291 1
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.0291 0.2425
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0067 0.0127 0.0387
Plasmodium vivax hypothetical protein, conserved 0.0188 0.0417 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0135 0.0291 0.0286
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0188 0.0417 0.1697
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0058 0.1856
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.002 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0232
Plasmodium vivax hypothetical protein, conserved 0.003 0.004 0.0858
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0092 0.0189 0.1558
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0018 0.0011 0.0019
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0007 0.0008
Mycobacterium tuberculosis Conserved protein 0.0188 0.0417 0.1323
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.002 0.0017 0.0048
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Schistosoma mansoni aldehyde dehydrogenase 0.0326 0.0747 0.4403
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0053 0.0094 0.0281
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0135 0.0291 0.6929
Mycobacterium ulcerans hypothetical protein 0.0188 0.0417 0.1309
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0042 0.0133
Brugia malayi hypothetical protein 0.0025 0.0027 0.0103
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.002 0.0017 0.007
Brugia malayi Pre-SET motif family protein 0.0448 0.1035 0.4224
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0011 0.0147
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Mycobacterium ulcerans hypothetical protein 0.0053 0.0094 0.0281
Onchocerca volvulus 0.0188 0.0417 0.35
Loa Loa (eye worm) hypothetical protein 0.0059 0.0108 0.0421
Entamoeba histolytica hypothetical protein 0.0114 0.0241 0.8254
Giardia lamblia Short-chain dehydrogenase, putative 0.0031 0.0042 0.1106
Brugia malayi Heterochromatin protein 1 0.0072 0.0141 0.0566
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0026
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0031 0.0042 0.0133
Echinococcus granulosus nuclear receptor nhr 48 0.0045 0.0076 0.0289
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0071 0.0137 1
Onchocerca volvulus 0.0148 0.0321 0.2678
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.0448 0.1822
Onchocerca volvulus 0.0016 0.0007 0.0017
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0031 0.0042 0.0037
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0031 0.0042 0.0897
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.002 0.0017 0.0048
Echinococcus multilocularis aryl hydrocarbon receptor 0.0046 0.0078 0.0073
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.0137 0.3212
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.0196 0.0792
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0232
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0045 0.0077 0.0606
Brugia malayi ecdysone receptor 0.0045 0.0076 0.03
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0031 0.0042 0.0133
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0053 0.167
Onchocerca volvulus 0.0031 0.0042 0.0314
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0005 0.0012
Brugia malayi orphan nuclear receptor NR2E1 0.0045 0.0076 0.03
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0042 0.0133
Loa Loa (eye worm) hypothetical protein 0.0053 0.0094 0.0362
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0018 0.0011 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0095 0.0196 0.0792
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0095 0.0196 0.1132
Echinococcus multilocularis chromobox protein 1 0.0072 0.0141 0.0136
Loa Loa (eye worm) oxidoreductase 0.0031 0.0042 0.0151
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0095 0.0196 0.0781
Echinococcus multilocularis lamin dm0 0.0057 0.0104 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0161 0.0353 0.2957
Brugia malayi bHLH-PAS transcription factor 0.0129 0.0276 0.1121
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0026
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0045 0.0076 0.0071
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.0137 0.1785
Brugia malayi Ets-domain containing protein 0.0071 0.0138 0.0553
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0094 0.0281
Loa Loa (eye worm) cytochrome P450 0.0067 0.0127 0.0499
Schistosoma mansoni steroid hormone receptor ad4bp 0.0095 0.0196 0.1132
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0071 0.0137 0.1785
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0058 0.168
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.029 0.2423
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0319 0.0314
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0008
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0018 0.0011 0.0035
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0011 0.0082
Echinococcus multilocularis ubiquitin specific protease 41 0.0135 0.0291 0.0286
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0034 0.0029
Schistosoma mansoni retinal dehydrogenase 0.0031 0.0042 0.022
Schistosoma mansoni steroid dehydrogenase 0.0031 0.0042 0.022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0196 0.0191
Leishmania major hypothetical protein, conserved 0.0031 0.0042 0.0499
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Trypanosoma brucei short-chain dehydrogenase, putative 0.0031 0.0042 0.0897
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.0042 0.0499
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0018 0.0011 0.0212
Brugia malayi Smad1 0.0016 0.0006 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0095 0.0196 0.0792
Leishmania major cytochrome p450-like protein 0.0067 0.0127 0.1644
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0006 0.0001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0135 0.0291 0.2425
Loa Loa (eye worm) G protein alpha subunit 3 0.002 0.0017 0.0048
Echinococcus granulosus WW domain containing oxidoreductase 0.0031 0.0042 0.0151
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0225 0.0505 0.2054
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0214 0.0865
Giardia lamblia Kinase, CMGC MAPK 0.0093 0.019 0.6406
Brugia malayi N-terminal motif family protein 0.0196 0.0435 0.1768
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0094 0.1193
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0006 0.0001
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0031 0.0042 0.1106
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0135 0.029 0.3849
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0193 0.0428 0.1731
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0031 0.0042 0.0314
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0053 0.0405
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0067 0.0127 0.0387
Giardia lamblia Hypothetical protein 0.0031 0.0042 0.1106
Echinococcus multilocularis peregrin 0.0038 0.0059 0.0054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0188 0.0417 0.1323
Onchocerca volvulus 0.0031 0.0042 0.0314
Echinococcus granulosus geminin 0.0356 0.0817 0.3324
Trichomonas vaginalis glucosylceramidase, putative 0.0246 0.0555 0.467
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.002 0.0017 0.0012
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0031 0.0042 0.0897
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0071 0.0137 0.042
Loa Loa (eye worm) beta-lactamase 0.0188 0.0417 0.1687
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0048
Echinococcus granulosus steroid dehydrogenase 0.0031 0.0042 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0095 0.0196 0.0781
Loa Loa (eye worm) hypothetical protein 0.0264 0.0597 0.2423
Echinococcus multilocularis cysteine protease 0.0016 0.0007 0.0002
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0041 0.016
Brugia malayi hypothetical protein 0.0016 0.0006 0.0018
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0076 0.03
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0018 0.0011 0.0019
Echinococcus granulosus cathepsin l1 0.0016 0.0007 0.0008
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0045 0.0076 0.0419
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0067 0.0127 0.0403
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0018 0.0011 0.0147
Schistosoma mansoni steroid dehydrogenase 0.0031 0.0042 0.022
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0092 0.0189 0.2474
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0053 0.0195
Mycobacterium ulcerans putative regulatory protein 0.0129 0.0276 0.0862
Brugia malayi acetyltransferase, GNAT family protein 0.0314 0.0717 0.2923
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.0196 0.0792
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.0417 0.35
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0499
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0188 0.0417 0.2447
Mycobacterium ulcerans ketoacyl reductase 0.0031 0.0042 0.0117
Onchocerca volvulus 0.0057 0.0104 0.0843
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0005 0.0012
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0067 0.0127 0.0403
Brugia malayi hypothetical protein 0.0264 0.0597 0.2432
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0067 0.0127 0.0403
Onchocerca volvulus 0.0016 0.0007 0.0017
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0474 0.1099 0.4478
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0058 0.0053
Onchocerca volvulus 0.0031 0.0042 0.0314
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0011 0.0147
Schistosoma mansoni patched 1 0.0044 0.0074 0.0407
Leishmania major hypothetical protein, conserved 0.0031 0.0042 0.0499
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.029 0.2423
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0056 0.0207
Mycobacterium ulcerans lipase LipD 0.0188 0.0417 0.1309
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0067 0.0127 0.0403
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0135 0.029 0.2423
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Schistosoma mansoni steroid dehydrogenase 0.0031 0.0042 0.022
Onchocerca volvulus 0.0045 0.0077 0.0606
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0196 0.0781
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.002
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.002 0.0017 0.0048
Brugia malayi nuclear hormone receptor 0.0045 0.0076 0.03
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0093 0.019 0.2497
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0018 0.0011 0.0035
Onchocerca volvulus Glucosylceramidase homolog 0.0161 0.0353 0.2957
Mycobacterium ulcerans esterase/lipase LipP 0.0188 0.0417 0.1309
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0058 0.0715
Leishmania major cytochrome p450-like protein 0.0067 0.0127 0.1644
Echinococcus granulosus beta LACTamase domain containing family member 0.0188 0.0417 0.1687
Leishmania major short chain dehydrogenase, putative 0.0031 0.0042 0.0499
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0053 0.0094 0.0297
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.012 0.047
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.002 0.0017 0.0012
Echinococcus granulosus hypothetical protein 0.0031 0.0042 0.0151
Echinococcus granulosus guanine nucleotide binding protein G protein 0.002 0.0017 0.0048
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.002
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0045 0.0077 0.0606
Brugia malayi conserved hypotetical protein 0.0045 0.0076 0.03
Loa Loa (eye worm) hypothetical protein 0.0188 0.0417 0.1687
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0027 0.0782
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0031 0.0042 0.0037
Onchocerca volvulus 0.0016 0.0007 0.0017
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0031 0.0042 0.022
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0034 0.0118
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0104 0.0406
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0017
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0018 0.0011 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0094 0.0374
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0011 0.0147
Onchocerca volvulus Bile acid receptor homolog 0.0095 0.0196 0.1619
Loa Loa (eye worm) hypothetical protein 0.0095 0.0196 0.0781
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0135 0.029 0.1179
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0095 0.0196 0.0781
Echinococcus multilocularis survival motor neuron protein 1 0.104 0.2448 0.2444
Brugia malayi hypothetical protein 0.005 0.0088 0.0353
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Trypanosoma cruzi short chain dehydrogenase, putative 0.0031 0.0042 0.0897
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0007 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0005 0.0012
Plasmodium vivax vivapain-2 0.0016 0.0007 0.0047
Loa Loa (eye worm) hypothetical protein 0.0052 0.0092 0.0356
Toxoplasma gondii carbonyl reductase 1, putative 0.0031 0.0042 0.0499
Leishmania major protein kinase, putative 0.005 0.0089 0.1126
Echinococcus multilocularis caspase 2 0.0283 0.0643 0.0638
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0027 0.0541
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.019 0.1572
Onchocerca volvulus 0.0031 0.0042 0.0314
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0017 0.01
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0046 0.0078 0.0073
Brugia malayi oxidoreductase 0.0031 0.0042 0.0163
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0046 0.0079 0.1781
Echinococcus multilocularis chromobox protein 1 0.0072 0.0141 0.0136
Echinococcus granulosus intermediate filament protein 0.0057 0.0104 0.0406
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0031 0.0042 0.0163
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0225 0.0505 0.05
Schistosoma mansoni ets-related 0.0215 0.0482 0.2832
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.002 0.0017 0.006
Brugia malayi dehydrogenases, short chain protein 2 0.0031 0.0042 0.0163
Echinococcus granulosus thyroid hormone receptor alpha 0.0045 0.0076 0.0289
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0058 0.0168
Leishmania major cytochrome p450-like protein 0.0125 0.0267 0.3527
Echinococcus multilocularis retinol dehydrogenase 11 0.0031 0.0042 0.0037
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0093 0.019 0.4492
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.019 0.1099
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0048
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0031 0.0042 0.0897
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.012 0.0115
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0018 0.0011 0.0025
Schistosoma mansoni hypothetical protein 0.0114 0.0241 0.14
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.0042 0.0499
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.0042 0.0314
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0062 0.0196
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0062 0.199
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Schistosoma mansoni lamin 0.0057 0.0104 0.059
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0031 0.0042 0.0499
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0011 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0007 0.0012
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0116 0.0453
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0095 0.0196 0.0792
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0069 0.026
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0042 0.1295
Brugia malayi hypothetical protein 0.0031 0.0042 0.0163
Schistosoma mansoni steroid dehydrogenase 0.0031 0.0042 0.022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0188 0.0417 0.1323
Echinococcus multilocularis carbonyl reductase 1 0.0031 0.0042 0.0037
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0018 0.0011 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0027 0.0782
Leishmania major 3-keto-dihydrosphingosine reductase 0.0031 0.0042 0.0499
Schistosoma mansoni ap endonuclease 0.0038 0.0058 0.0315
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0067 0.0127 0.0403
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.012 0.047
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0135 0.029 0.2423
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0008
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0006 0.0005
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0031 0.0042 0.0133
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0067 0.0127 0.0387
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0064 0.012 0.038
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0135 0.0291 0.1696
Brugia malayi hypothetical protein 0.0586 0.1365 0.5571
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Trypanosoma brucei glucosidase, putative 0.0035 0.0053 0.1157
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0041 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0007 0.0017
Entamoeba histolytica short chain dehydrogenase family protein 0.0031 0.0042 0.1295
Echinococcus granulosus chromobox protein 1 0.0072 0.0141 0.0555
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0031 0.0042 0.1295
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0018 0.0011 0.0019
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0046 0.0079 0.1781
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0007 0.0047
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0067 0.0127 0.0387
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0018 0.0011 0.0147
Brugia malayi hypothetical protein 0.0045 0.0076 0.03
Mycobacterium ulcerans TetR family transcriptional regulator 0.1336 0.3153 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0135 0.029 0.2423
Onchocerca volvulus 0.0031 0.0042 0.0314
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Loa Loa (eye worm) dehydrogenase 0.0031 0.0042 0.0151
Schistosoma mansoni retinoic acid receptor RXR 0.0095 0.0196 0.1132
Mycobacterium leprae Probable lipase LipE 0.0188 0.0417 0.1309
Echinococcus granulosus tumor protein p63 0.0332 0.0759 0.3087
Leishmania major metacaspase, putative 0.0135 0.029 0.3849
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.0349 0.1408
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0011 0.0147
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0067 0.0127 0.0387
Loa Loa (eye worm) oxidoreductase 0.0031 0.0042 0.0151
Schistosoma mansoni single-minded 0.0175 0.0385 0.2253
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.002
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0246 0.0555 0.2251
Brugia malayi hypothetical protein 0.0045 0.0076 0.03
Echinococcus granulosus hypothetical protein 0.0031 0.0042 0.0151
Loa Loa (eye worm) hypoxia-induced factor 1 0.054 0.1257 0.5123
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0031 0.0042 0.0897
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0057 0.018
Loa Loa (eye worm) hypothetical protein 0.0283 0.0643 0.261
Trypanosoma brucei metacaspase MCA2 0.0135 0.029 0.6925
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0053 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.029 0.2423
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.004 0.0145
Trichomonas vaginalis glucosylceramidase, putative 0.0246 0.0555 0.467
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0007 0.0017
Echinococcus granulosus caspase 0.0332 0.0759 0.3085
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0007 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0428 0.2511
Toxoplasma gondii oxidoreductase, putative 0.0031 0.0042 0.0499
Loa Loa (eye worm) hypothetical protein 0.0095 0.0196 0.0781
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0042 0.0897
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.029 0.2423
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0108
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Schistosoma mansoni hypothetical protein 0.0064 0.012 0.0682
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0474 0.1099 0.1094
Brugia malayi nuclear hormone receptor family member odr-7 0.0045 0.0076 0.03
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0053 0.0195
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0018 0.0011 0.0147
Echinococcus granulosus single minded 2 0.0129 0.0276 0.1111
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0116 0.2687
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.002 0.0017 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0057 0.018
Entamoeba histolytica hypothetical protein 0.0031 0.0042 0.1295
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0027 0.0541
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0067 0.0127 0.0387
Loa Loa (eye worm) PHD-finger family protein 0.003 0.004 0.0145
Echinococcus granulosus apoptotic protease activating factor 1 0.0148 0.0321 0.1291
Trypanosoma brucei cytochrome P450, putative 0.0125 0.0267 0.6345
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0135 0.029 0.2423
Echinococcus multilocularis lamin 0.0057 0.0104 0.0099
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.004 0.021
Loa Loa (eye worm) oxidoreductase 0.0031 0.0042 0.0151
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0067 0.0127 0.0403
Brugia malayi beta-lactamase 0.0188 0.0417 0.1697
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Schistosoma mansoni steroid dehydrogenase 0.0031 0.0042 0.022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0095 0.0196 0.0792
Plasmodium vivax metacaspase 1, putative 0.0135 0.029 0.6925
Mycobacterium ulcerans short-chain dehydrogenase 0.0031 0.0042 0.0117
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.0042 0.0314
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.0017 0.006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0094 0.0362
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0067 0.0127 0.0387
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0428 0.2511
Onchocerca volvulus 0.0049 0.0084 0.0671
Loa Loa (eye worm) hypothetical protein 0.0095 0.0196 0.0781
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0067 0.0127 0.0387
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0027 0.0301
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0053 0.0207
Onchocerca volvulus 0.0076 0.015 0.1227
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0076 0.0289
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0093 0.019 0.0758
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0036
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0058 0.0229
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1336 0.3153 1
Plasmodium vivax vivapain-2 0.0016 0.0007 0.0047
Mycobacterium ulcerans dehydrogenase 0.0031 0.0042 0.0117
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0031 0.0042 0.0897
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0076 0.015 0.0858
Toxoplasma gondii oxidoreductase, putative 0.0031 0.0042 0.0499
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0093 0.019 0.4492
Leishmania major pteridine reductase 1 0.0031 0.0042 0.0499
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0005 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0095 0.0196 0.0792
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0017
Echinococcus granulosus caspase 2 0.0283 0.0643 0.261
Leishmania major hypothetical protein, conserved 0.0031 0.0042 0.0499
Echinococcus multilocularis steroid dehydrogenase 0.0031 0.0042 0.0037
Trichomonas vaginalis penicillin-binding protein, putative 0.0188 0.0417 0.35
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0314 0.0717 0.4228
Mycobacterium ulcerans short-chain dehydrogenase 0.0031 0.0042 0.0117
Brugia malayi Retinol dehydrogenase 12 0.0031 0.0042 0.0163
Leishmania major aldehyde dehydrogenase, putative 0.0018 0.0011 0.0082
Onchocerca volvulus 0.0188 0.0417 0.35
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0018 0.0011 0.0019
Plasmodium falciparum steroid dehydrogenase, putative 0.0031 0.0042 0.1296
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0018 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Brugia malayi tailless protein 0.0045 0.0076 0.03
Mycobacterium tuberculosis Possible oxidoreductase 0.0031 0.0042 0.0133
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Echinococcus multilocularis microtubule associated protein 2 0.0722 0.1689 0.1685
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.0042 0.0314
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.002 0.0017 0.006
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0011 0.0147
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0116 0.2687
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0071 0.0137 0.4636
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0527 0.2135
Loa Loa (eye worm) DR-78 0.0045 0.0076 0.0289
Entamoeba histolytica short chain dehydrogenase family protein 0.0031 0.0042 0.1295
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0018 0.0011 0.0051
Schistosoma mansoni nuclear receptor 0.0045 0.0076 0.0419
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0135 0.029 0.1695
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0058 0.1857
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0092 0.0189 0.2474
Leishmania major short chain dehydrogenase-like protein 0.0031 0.0042 0.0499
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0053 0.0094 0.0281
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.0017 0.007
Brugia malayi Bromodomain containing protein 0.0038 0.0059 0.0232
Loa Loa (eye worm) hypothetical protein 0.0053 0.0094 0.0362
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0018 0.0011 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0017
Brugia malayi hypothetical protein 0.002 0.0017 0.006
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.0095 0.0196 0.0792
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0428 0.2511
Onchocerca volvulus 0.0045 0.0076 0.0599
Echinococcus granulosus peregrin 0.0038 0.0059 0.022
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0053 0.0405
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.0042 0.0314
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0045 0.0076 0.03
Echinococcus granulosus ubiquitin specific protease 41 0.0135 0.0291 0.1169
Mycobacterium ulcerans ketoacyl reductase 0.0031 0.0042 0.0117
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0018 0.0011 0.0035
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Mycobacterium ulcerans beta-lactamase 0.0188 0.0417 0.1309
Schistosoma mansoni intermediate filament proteins 0.0057 0.0104 0.059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0017
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.0349 0.1408
Brugia malayi jmjC domain containing protein 0.0099 0.0205 0.0827
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0031 0.0042 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0025
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0053 0.0643
Echinococcus granulosus guanine nucleotide binding protein subunit 0.002 0.0017 0.0048
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0225 0.0505 0.2966
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.0188 0.0417 0.1687
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.002 0.0017 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0161 0.0353 0.2957
Echinococcus multilocularis caspase 0.0332 0.0759 0.0754
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0225 0.0505 0.6736
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0062 0.018
Mycobacterium tuberculosis Probable dehydrogenase 0.0031 0.0042 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Mycobacterium tuberculosis Probable lipase LipE 0.0188 0.0417 0.1323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.0196 0.0792
Echinococcus multilocularis expressed conserved protein 0.0097 0.0199 0.0194
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0048
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0225 0.0505 0.16
Brugia malayi G-protein alpha subunit 0.002 0.0017 0.006
Echinococcus granulosus microtubule associated protein 2 0.0722 0.1689 0.6894
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.0042 0.0499
Loa Loa (eye worm) oxidoreductase 0.0031 0.0042 0.0151
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0005 0.0016
Echinococcus granulosus carbonyl reductase 1 0.0031 0.0042 0.0151
Echinococcus granulosus chromobox protein 1 0.0072 0.0141 0.0555
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0225 0.0505 0.1586
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0042 0.0133
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0017
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0018 0.0011 0.0035
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0018 0.0011 0.0035
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0074 0.0281
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.0417 0.35
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0018 0.0011 0.0019
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0319 0.1286
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0037 0.0269
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.002 0.0017 0.007
Schistosoma mansoni hypothetical protein 0.0067 0.0127 0.0724
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0018 0.0011 0.0019
Onchocerca volvulus 0.0057 0.0104 0.0843
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0045 0.0077 0.1733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0017
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.002
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0005 0.0016
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0056 0.0207
Mycobacterium ulcerans aldehyde dehydrogenase 0.0326 0.0747 0.2355
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0094 0.0297
Schistosoma mansoni steroid dehydrogenase 0.0031 0.0042 0.022
Trichomonas vaginalis bromodomain-containing protein, putative 0.0092 0.0189 0.1558
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.0042 0.0499
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0031 0.0042 0.0897
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0011 0.0036
Onchocerca volvulus Sepiapterin reductase homolog 0.0031 0.0042 0.0314
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.002
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0072 0.057
Onchocerca volvulus 0.0031 0.0042 0.0314
Trypanosoma brucei short-chain dehydrogenase, putative 0.0031 0.0042 0.0897
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0246 0.0555 0.2261
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0018 0.0011 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0474 0.1099 0.1094
Brugia malayi hypoxia-induced factor 1 0.054 0.1257 0.5129
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0007 0.0017
Trypanosoma brucei Metacaspase-4 0.0135 0.029 0.6925
Brugia malayi jmjC domain containing protein 0.0037 0.0056 0.0219
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0007 0.0002
Brugia malayi Dehydrogenases, short chain protein 2 0.0031 0.0042 0.0163
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0076 0.0419
Echinococcus multilocularis cysteine protease 0.0016 0.0007 0.0002
Schistosoma mansoni carbonyl reductase 0.0031 0.0042 0.022
Trichomonas vaginalis inositol monophosphatase, putative 0.0071 0.0137 0.1124
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0121 0.0116
Echinococcus granulosus Smad4 0.0016 0.0006 0.0005
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0018 0.0011 0.0006
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0018 0.0011 0.0025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0095 0.0196 0.0781
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0095 0.0196 0.0781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0094 0.3097
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0018 0.0011 0.0019
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0045 0.0077 0.0606
Loa Loa (eye worm) hypothetical protein 0.0264 0.0597 0.2423
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0125 0.0267 0.0831
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0474 0.1099 0.6496
Loa Loa (eye worm) hypothetical protein 0.0201 0.0448 0.1812
Echinococcus granulosus histone acetyltransferase KAT2B 0.0305 0.0696 0.2829
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.002 0.0017 0.006
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0046 0.0078 0.0298
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0314 0.0717 0.0712
Loa Loa (eye worm) hypothetical protein 0.0095 0.0196 0.0781
Loa Loa (eye worm) TAR-binding protein 0.0193 0.0428 0.1731
Leishmania major hypothetical protein, conserved 0.0031 0.0042 0.0499
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0141 0.1151
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0045 0.0077 0.0606
Schistosoma mansoni hypothetical protein 0.0356 0.0817 0.4822
Echinococcus multilocularis 0.0067 0.0127 0.0122
Schistosoma mansoni hypothetical protein 0.0043 0.007 0.0385
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0067 0.0127 0.0403
Mycobacterium ulcerans transcriptional regulator 0.1336 0.3153 1
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Trypanosoma brucei short-chain dehydrogenase, putative 0.0031 0.0042 0.0897
Onchocerca volvulus Alhambra homolog 0.003 0.004 0.03
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1203 0.2836 0.8994
Loa Loa (eye worm) hypothetical protein 0.0054 0.0097 0.0378
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0074 0.0281
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0005 0.0016
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.002 0.0017 0.007
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0018 0.0011 0.0025
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0067 0.0127 0.0403
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0095 0.0196 0.1132
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0018 0.0011 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Onchocerca volvulus 0.0212 0.0474 0.3983
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.0017 0.006
Loa Loa (eye worm) hypothetical protein 0.0137 0.0296 0.1191
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0076 0.0071
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.002 0.0017 0.006
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0031 0.0042 0.0133
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0095 0.0196 0.1132
Loa Loa (eye worm) hypothetical protein 0.0188 0.0417 0.1687
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0067 0.0127 0.0387
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0018 0.0011 0.0051
Schistosoma mansoni hypothetical protein 0.0064 0.012 0.0682
Toxoplasma gondii exonuclease III APE 0.0038 0.0058 0.0715
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Leishmania major protein kinase, putative 0.0046 0.0079 0.099
Trypanosoma cruzi cytochrome P450, putative 0.0125 0.0267 0.6345
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0058 0.1286
Echinococcus granulosus transcription factor eb 0.0126 0.0269 0.1081
Echinococcus multilocularis geminin 0.0356 0.0817 0.0812
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0018 0.0011 0.0147
Echinococcus multilocularis steroid dehydrogenase 0.0031 0.0042 0.0037
Onchocerca volvulus 0.0016 0.0007 0.0017
Trypanosoma cruzi short chain dehydrogenase, putative 0.0031 0.0042 0.0897
Brugia malayi Fli-1 protein 0.0215 0.0482 0.1962
Schistosoma mansoni survival motor neuron protein 0.0212 0.0474 0.2785
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0067 0.0127 0.0387
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0103 0.2377
Brugia malayi Latrophilin receptor protein 2 0.0064 0.012 0.0482
Echinococcus granulosus lamin dm0 0.0057 0.0104 0.0406
Trichomonas vaginalis steroid dehydrogenase, putative 0.0031 0.0042 0.0314
Loa Loa (eye worm) nuclear receptor NHR-67 0.0045 0.0076 0.0289
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Brugia malayi beta-lactamase family protein 0.0188 0.0417 0.1697
Giardia lamblia Reductase, putative 0.0031 0.0042 0.1106
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0045 0.0076 0.0071
Schistosoma mansoni inositol monophosphatase 0.0071 0.0137 0.0786
Brugia malayi aldehyde dehydrogenase 0.0018 0.0011 0.0037
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0121 0.0116
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0018 0.0011 0.0147
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0031 0.0042 0.0897
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0188 0.0417 0.2447
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0046 0.0079 0.1781
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0018 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Echinococcus multilocularis protein patched 0.0044 0.0074 0.0069
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0018 0.0011 0.0025
Echinococcus granulosus tar DNA binding protein 0.0193 0.0428 0.1731
Echinococcus multilocularis retinol dehydrogenase 13 0.0031 0.0042 0.0037
Loa Loa (eye worm) acetyltransferase 0.0314 0.0717 0.2915
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0241 0.0965
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0374 0.3133
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0077 0.0606
Loa Loa (eye worm) hypothetical protein 0.0095 0.0196 0.0781
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0031 0.0042 0.0151
Loa Loa (eye worm) fli-1 protein 0.0215 0.0482 0.1952
Schistosoma mansoni chromobox protein 0.0072 0.0141 0.0805
Loa Loa (eye worm) hypothetical protein 0.0152 0.033 0.1331
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0018 0.0011 0.0147
Schistosoma mansoni alpha-glucosidase 0.0137 0.0296 0.1727
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0018 0.0011 0.0035
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0084 0.0469
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0045 0.0077 1
Loa Loa (eye worm) oxidoreductase 0.0031 0.0042 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0042 0.0897
Loa Loa (eye worm) nuclear hormone receptor 0.0045 0.0076 0.0289
Mycobacterium ulcerans carveol-like dehydrogenase 0.0031 0.0042 0.0117
Onchocerca volvulus Huntingtin homolog 0.0264 0.0597 0.5026
Schistosoma mansoni chromobox protein 0.0072 0.0141 0.0805
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0474 0.1099 0.4485
Echinococcus multilocularis FTZ F1 alpha 0.0095 0.0196 0.0191
Echinococcus granulosus carbonyl reductase 1 0.0031 0.0042 0.0151
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0094 0.0281
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0031 0.0042 0.0897
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0026
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.0349 0.1418
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0018 0.0011 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Brugia malayi Cytochrome P450 family protein 0.0154 0.0336 0.1364
Schistosoma mansoni nuclear receptor nhr-48 0.0045 0.0076 0.0419
Mycobacterium ulcerans dehydrogenase/reductase 0.0031 0.0042 0.0117
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Echinococcus granulosus mitogen activated protein kinase 0.0093 0.019 0.0758
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0045 0.0076 0.0419
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0057 0.018
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0474 0.1099 0.6496
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0071 0.0137 0.1124
Loa Loa (eye worm) cytochrome P450 family protein 0.0154 0.0336 0.1354
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0341
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0031 0.0042 0.0314
Onchocerca volvulus 0.0031 0.0042 0.0314
Loa Loa (eye worm) ctsf protein 0.0016 0.0007 0.0008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0135 0.029 0.2423
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0156 0.0896
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0058 0.0217
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0031 0.0042 0.0897
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0067 0.0127 0.0387
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0067 0.0127 0.0387
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Loa Loa (eye worm) hypothetical protein 0.0041 0.0065 0.0245
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0133
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0116 0.2687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Schistosoma mansoni carbonyl reductase 0.0031 0.0042 0.022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0214 0.0209
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0031 0.0042 0.0037
Echinococcus multilocularis transfer RNA-Lys 0.0129 0.0276 0.0271
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0042 0.0133
Mycobacterium leprae Possible regulatory protein 0.0045 0.0077 0.0227
Leishmania major cathepsin L-like protease 0.0062 0.0116 0.1494
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0053 0.0405
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.0042 0.0499
Mycobacterium ulcerans oxidoreductase 0.0031 0.0042 0.0117
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0031 0.0042 0.2448
Brugia malayi hypothetical protein 0.0114 0.0241 0.0976
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0042 0.0897
Brugia malayi nuclear receptor NHR-67 0.0045 0.0076 0.03
Loa Loa (eye worm) hypothetical protein 0.0148 0.0321 0.1291
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0095 0.0196 0.0781
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0031 0.0042 0.0117
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.002 0.0017 0.007
Brugia malayi hypothetical protein 0.005 0.0088 0.0353
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.002 0.0017 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0121 0.069
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0088 0.0353
Schistosoma mansoni hypothetical protein 0.0137 0.0296 0.1728
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0074 0.0069
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0076 0.0419
Echinococcus multilocularis caspase 3 0.0196 0.0437 0.0432
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0121 0.069
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0135 0.0291 0.3851
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0094 0.0281
Echinococcus granulosus lamin 0.0057 0.0104 0.0406
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0046 0.0078 0.0298
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0005 0.0012
Plasmodium vivax steroid dehydrogenase, putative 0.0031 0.0042 0.0897
Brugia malayi beta-lactamase family protein 0.0188 0.0417 0.1697
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Brugia malayi hypothetical protein 0.0148 0.0321 0.1302
Echinococcus multilocularis mitogen activated protein kinase 3 0.0093 0.019 0.0185
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0499
Plasmodium falciparum phd finger protein, putative 0.003 0.004 0.1239
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0018 0.0011 0.0037
Onchocerca volvulus 0.0032 0.0044 0.0331
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0499
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0084 0.1921
Echinococcus granulosus expressed protein 0.002 0.0017 0.0048
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0188 0.0417 0.1687
Loa Loa (eye worm) inositol-1 0.0071 0.0137 0.0542
Trypanosoma brucei hypothetical protein, conserved 0.0188 0.0417 1
Schistosoma mansoni thyroid hormone receptor 0.0095 0.0196 0.1132
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0232
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0031 0.0042 0.0163
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.0042 0.0499
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Echinococcus multilocularis carbonyl reductase 1 0.0031 0.0042 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.0448 0.1812
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0074 0.0582
Brugia malayi dehydrogenases, short chain protein 9 0.0031 0.0042 0.0163
Echinococcus granulosus mitogen activated protein kinase 3 0.0093 0.019 0.0758
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.019 0.1572
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.002 0.0017 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0095 0.0196 0.0781
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.019 0.1572
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0045 0.0077 0.1733
Schistosoma mansoni steroid dehydrogenase 0.0031 0.0042 0.022
Echinococcus multilocularis oxidoreductase 0.0031 0.0042 0.0037
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0135 0.029 0.2423
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0007 0.0002
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0135 0.0291 0.6929
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0094 0.0374
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0094 0.3097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0095 0.0196 0.1132
Loa Loa (eye worm) RNA binding protein 0.0193 0.0428 0.1731
Onchocerca volvulus 0.0092 0.0188 0.1557
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Schistosoma mansoni hypothetical protein 0.0148 0.0321 0.1873
Schistosoma mansoni trimeric G-protein alpha o subunit 0.002 0.0017 0.007
Loa Loa (eye worm) aldehyde dehydrogenase 0.0018 0.0011 0.0025
Schistosoma mansoni cytochrome P450 0.0067 0.0127 0.0724
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0058 0.3716
Mycobacterium tuberculosis Probable hydrolase 0.0188 0.0417 0.1323
Schistosoma mansoni hypothetical protein 0.0043 0.007 0.0385
Mycobacterium tuberculosis Conserved protein 0.0188 0.0417 0.1323
Brugia malayi follicle stimulating hormone receptor 0.0406 0.0936 0.3817
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.029 0.2423
Echinococcus multilocularis inositol monophosphatase 1 0.0071 0.0137 0.0132
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0095 0.0196 0.0781
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0092 0.0189 0.4451
Mycobacterium tuberculosis Probable lipase LipD 0.0188 0.0417 0.1323
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0067 0.0127 0.2957
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0031 0.0042 0.0499
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0007 0.0068
Brugia malayi hypothetical protein 0.0152 0.033 0.1342
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0141 0.1151
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Loa Loa (eye worm) hypothetical protein 0.0103 0.0214 0.0854
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0031 0.0042 0.0314
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0006 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0094 0.1193
Schistosoma mansoni ap endonuclease 0.0038 0.0058 0.0315
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0006 0.0005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0121 0.1568
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Echinococcus granulosus guanine nucleotide binding protein subunit 0.002 0.0017 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0326 0.0747 0.2355
Toxoplasma gondii cathepsin CPL 0.0016 0.0007 0.0026
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0031 0.0042 0.0897
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0018 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0057 0.0104 0.0406
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0018 0.0011 0.0019
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0067 0.0127 0.0387
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0205 0.02
Echinococcus granulosus caspase 8 0.0135 0.029 0.1168
Trypanosoma brucei oxidoreductase-like protein 0.0031 0.0042 0.0897
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0241 0.0236
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0074 0.0281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0017
Echinococcus granulosus histone acetyltransferase KAT2B 0.0092 0.0189 0.0751
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0031 0.0042 0.0037
Schistosoma mansoni caspase-7 (C14 family) 0.0332 0.0759 0.4475
Leishmania major hypothetical protein, conserved 0.0188 0.0417 0.5559
Echinococcus multilocularis transcription factor eb 0.0126 0.0269 0.0264
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0076 0.03
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0005 0.0012
Echinococcus multilocularis mitogen activated protein kinase 0.0093 0.019 0.0185
Mycobacterium ulcerans aldehyde dehydrogenase 0.0326 0.0747 0.2355
Trichomonas vaginalis adenylate cyclase, putative 0.0045 0.0077 0.0606
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0118
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0018 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0292
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0053 0.0094 0.0281
Mycobacterium tuberculosis Possible oxidoreductase 0.0031 0.0042 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0108
Schistosoma mansoni steroid dehydrogenase 0.0031 0.0042 0.022
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0135 0.0291 0.0286
Brugia malayi CHE-14 protein 0.0044 0.0074 0.0292
Schistosoma mansoni nuclear receptor 0.0045 0.0076 0.0419
Trypanosoma cruzi metacaspase, putative 0.0135 0.029 0.6925
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0126 0.0269 0.1092
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0018 0.0011 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0042 0.0897
Entamoeba histolytica cysteine protease, putative 0.0016 0.0007 0.0068
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0031 0.0042 0.022
Loa Loa (eye worm) hypothetical protein 0.0188 0.0417 0.1687
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0067 0.0127 0.0403
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0326 0.0747 0.2367
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0037 0.0269
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0042 0.0897
Echinococcus granulosus retinol dehydrogenase 11 0.0031 0.0042 0.0151
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0058 1
Onchocerca volvulus 0.0016 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0126 0.0268 0.1075
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0031 0.0042 0.0117
Leishmania major short chain dehydrogenase/reductase, putative 0.0031 0.0042 0.0499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Brugia malayi MH2 domain containing protein 0.0234 0.0527 0.2145
Brugia malayi nuclear receptor RXR 0.0045 0.0076 0.03
Loa Loa (eye worm) hypothetical protein 0.0061 0.0113 0.0442
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.0196 0.0792
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0076 0.0599
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.005 0.0088 0.0341
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0332 0.0759 0.3085
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0031 0.0042 0.0133
Loa Loa (eye worm) oxidoreductase 0.0031 0.0042 0.0151
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0031 0.0042 0.1296
Mycobacterium ulcerans short-chain dehydrogenase 0.0031 0.0042 0.0117
Brugia malayi nuclear hormone receptor 0.0095 0.0196 0.0792
Echinococcus granulosus ecdysone induced protein 78C 0.0095 0.0196 0.0781
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0135 0.0291 0.2425
Trypanosoma brucei metacaspase 5, putative 0.0135 0.029 0.6925
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0018 0.0011 0.0212
Leishmania major short chain dehydrogenase, putative 0.0031 0.0042 0.0499
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0088 0.0353
Schistosoma mansoni GTP-binding protein alpha subunit 0.002 0.0017 0.007
Echinococcus multilocularis Smad4 0.0016 0.0006 0.0001
Leishmania major dehydrogenase-like protein 0.0031 0.0042 0.0499
Plasmodium falciparum metacaspase-like protein 0.0135 0.029 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0341
Schistosoma mansoni carbonyl reductase 0.0031 0.0042 0.022
Brugia malayi RNA recognition motif domain containing protein 0.0193 0.0428 0.1741
Onchocerca volvulus 0.0509 0.1183 1
Echinococcus granulosus oxidoreductase 0.0031 0.0042 0.0151
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0094 0.0281
Giardia lamblia PHD finger protein 15 0.003 0.004 0.1048
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0135 0.029 0.2423
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Loa Loa (eye worm) oxidoreductase 0.0031 0.0042 0.0151
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0145
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0042 0.0897
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0053 0.0405
Brugia malayi Cytochrome P450 family protein 0.0125 0.0267 0.1081
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.002 0.0017 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0065 0.0508
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0031 0.0042 0.0897
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0067 0.0127 0.0403
Echinococcus multilocularis expressed protein 0.002 0.0017 0.0012
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0017 0.01
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.002 0.0017 0.01
Schistosoma mansoni gabp alpha 0.0071 0.0138 0.0786
Schistosoma mansoni hypothetical protein 0.0064 0.012 0.0682
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0005 0.0016
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0031 0.0042 0.0117
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0053 0.0405
Echinococcus multilocularis nuclear receptor nhr 48 0.0045 0.0076 0.0071
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0205 0.0816
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0071 0.0137 0.1124
Mycobacterium leprae conserved hypothetical protein 0.0188 0.0417 0.1309
Schistosoma mansoni coup transcription factor 0.0095 0.0196 0.1132
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0072 0.057
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.017 0.5784
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0011 0.0147
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0053 0.0048
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0031 0.0042 0.0133
Loa Loa (eye worm) hypothetical protein 0.0064 0.012 0.047
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0031 0.0042 0.0117
Echinococcus granulosus carbonyl reductase 1 0.0031 0.0042 0.0151
Brugia malayi MAP kinase sur-1 0.0093 0.019 0.0769
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.002 0.0017 0.0048
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0095 0.0196 0.0191
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0067 0.0127 0.0387
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0135 0.0291 0.6929
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0067 0.0127 0.0387
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0406 0.0936 0.381
Echinococcus multilocularis tumor protein p63 0.0332 0.0759 0.0754
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0095 0.0196 0.1132
Schistosoma mansoni alpha glucosidase 0.0035 0.0053 0.0283
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0428 0.2511
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Mycobacterium tuberculosis Conserved protein 0.0188 0.0417 0.1323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0095 0.0196 0.0781
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0196 0.0781
Loa Loa (eye worm) cytochrome P450 family protein 0.0125 0.0267 0.107
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0091
Loa Loa (eye worm) hypothetical protein 0.0044 0.0074 0.0281
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0007 0.0068
Trypanosoma brucei protein kinase, putative 0.0093 0.019 0.4492
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0094 0.0374
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0031 0.0042 0.0133
Echinococcus multilocularis conserved hypothetical protein 0.0031 0.0042 0.0037
Schistosoma mansoni steroid dehydrogenase 0.0031 0.0042 0.022
Entamoeba histolytica acyl-coA synthetase, putative 0.0053 0.0094 0.3097
Schistosoma mansoni alpha-glucosidase 0.0137 0.0296 0.1727
Trypanosoma cruzi metacaspase 5, putative 0.0135 0.029 0.6925
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0031 0.0042 0.0133
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.012 0.047
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0076 0.0289
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Brugia malayi intermediate filament protein 0.0057 0.0104 0.0418
Entamoeba histolytica hypothetical protein 0.0114 0.0241 0.8254
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0031 0.0042 0.0133
Echinococcus granulosus FTZ F1 alpha 0.0095 0.0196 0.0781
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0196 0.0191
Schistosoma mansoni lamin 0.0057 0.0104 0.059
Onchocerca volvulus 0.0031 0.0042 0.0314
Loa Loa (eye worm) hypothetical protein 0.0196 0.0435 0.1758
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0586 0.1365 0.5566
Schistosoma mansoni hypothetical protein 0.0043 0.007 0.0385
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0326 0.0747 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0027 0.0541
Trichomonas vaginalis set domain proteins, putative 0.0509 0.1183 1
Brugia malayi TAR-binding protein 0.0193 0.0428 0.1741
Onchocerca volvulus 0.013 0.0278 0.2316
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0141 0.0555
Trichomonas vaginalis guanylate cyclase, putative 0.0045 0.0077 0.0606
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0214 0.731
Trichomonas vaginalis glucosylceramidase, putative 0.0161 0.0353 0.2957
Trypanosoma cruzi metacaspase, putative 0.0135 0.029 0.6925
Loa Loa (eye worm) steroid hormone receptor 0.0095 0.0196 0.0781
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0006 0.0005
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0133
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0017
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0045 0.0076 0.0289
Schistosoma mansoni zinc finger protein 0.0045 0.0076 0.0419
Trichomonas vaginalis glucosylceramidase, putative 0.0246 0.0555 0.467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.0137 0.3212
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0326 0.0747 0.3035
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0095 0.0196 0.0191
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0011 0.0147
Trypanosoma cruzi cytochrome P450, putative 0.0125 0.0267 0.6345
Leishmania major aldehyde dehydrogenase, putative 0.0018 0.0011 0.0082
Schistosoma mansoni caspase-3 (C14 family) 0.0332 0.0759 0.4475
Brugia malayi RNA binding protein 0.0193 0.0428 0.1741
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0093 0.019 0.4492
Onchocerca volvulus 0.002 0.0017 0.01
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0218 0.1262
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0135 0.0291 0.1169
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0053 0.0405
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Entamoeba histolytica hypothetical protein 0.0114 0.0241 0.8254
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0188 0.0417 0.1323
Echinococcus multilocularis musashi 0.0057 0.0104 0.0099
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0031 0.0042 0.0897
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0094 0.0281
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0212 0.0474 0.193
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0225 0.0505 0.2044
Loa Loa (eye worm) hypothetical protein 0.104 0.2448 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0031 0.0042 0.0897
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0042 0.0133
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0067 0.0127 0.0403
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0031 0.0042 0.0117
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0031 0.0042 0.1295
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Echinococcus multilocularis smad 0.0016 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0188 0.0417 0.1687
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.0196 0.0792
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0031 0.0042 0.1296
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.0017 0.007
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0018 0.0011 0.0147
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0018 0.0011 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Leishmania major hypothetical protein, conserved 0.0025 0.0027 0.0301
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0018 0.0011 0.0082
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0018 0.0011 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0161 0.0353 0.2957
Echinococcus multilocularis GPCR, family 2 0.0064 0.012 0.0115
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0067 0.0127 0.2957
Onchocerca volvulus 0.0188 0.0417 0.35
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0018 0.0011 0.0019
Brugia malayi nuclear hormone receptor family member nhr-6 0.0045 0.0076 0.03
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.0196 0.0792
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0072 0.057
Echinococcus granulosus survival motor neuron protein 1 0.104 0.2448 1
Trypanosoma cruzi metacaspase, putative 0.0135 0.029 0.6925
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0042 0.0133
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Schistosoma mansoni short chain dehydrogenase 0.0031 0.0042 0.022
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Brugia malayi chromobox protein homolog 3 0.0041 0.0065 0.0257
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0018 0.0011 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Schistosoma mansoni steroid dehydrogenase 0.0031 0.0042 0.022
Trypanosoma cruzi metacaspase, putative 0.0135 0.029 0.6925
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0018 0.0011 0.0212
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0031 0.0042 0.0897
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0042 0.0897
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0053 0.0405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0017
Trichomonas vaginalis esterase, putative 0.0188 0.0417 0.35
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0031 0.0042 0.0314
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0093 0.019 0.2497
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0062 0.1378
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.002
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0093 0.019 0.4492
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0474 0.1099 0.4478
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0135 0.029 0.2423
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0018 0.0011 0.0082
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.016
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.002 0.0017 0.006
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0031 0.0042 0.0151
Brugia malayi Cytochrome P450 family protein 0.0125 0.0267 0.1081
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0018 0.0011 0.0212
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0104 0.0418
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0031 0.0042 0.0117
Toxoplasma gondii aldehyde dehydrogenase 0.0326 0.0747 1
Leishmania major hypothetical protein, conserved 0.0031 0.0042 0.0499
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0018 0.0011 0.0036
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0005 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0246 0.0555 0.467
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0349 0.0344
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.0042 0.0314
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0104 0.0406
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0095 0.0196 0.0191
Trichomonas vaginalis guanylate cyclase, putative 0.0045 0.0077 0.0606
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0064 0.012 0.0364
Brugia malayi PAS domain containing protein 0.0175 0.0385 0.1563
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0121 0.0476
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0188 0.0417 0.1309
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0031 0.0042 0.1295
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0121 0.069
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Mycobacterium ulcerans ketoacyl reductase 0.0031 0.0042 0.0117
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0005 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0067 0.0127 0.0403
Loa Loa (eye worm) hypothetical protein 0.0056 0.0102 0.0396
Plasmodium vivax SET domain protein, putative 0.0064 0.0121 0.2821
Trichomonas vaginalis penicillin-binding protein, putative 0.0188 0.0417 0.35
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.004 0.0035
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.012 0.0115
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0133
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0031 0.0042 0.0897
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0018 0.0011 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0065 0.0508
Brugia malayi hypothetical protein 0.0031 0.0042 0.0163
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1336 0.3153 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0027 0.0541
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0031 0.0042 0.0897
Loa Loa (eye worm) hypothetical protein 0.0135 0.0291 0.1169
Echinococcus granulosus GPCR family 2 0.0064 0.012 0.047
Toxoplasma gondii cytochrome p450 superfamily protein 0.0067 0.0127 0.1644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0017
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0005 0.0016
Onchocerca volvulus 0.0095 0.0196 0.1619
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0138 0.0542
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0007 0.0008
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0007 0.0008
Schistosoma mansoni aryl hydrocarbon receptor 0.0175 0.0386 0.2262
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.0527 0.2135
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Schistosoma mansoni hypothetical protein 0.0043 0.007 0.0385
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0046 0.0079 0.1781
Echinococcus multilocularis caspase 8 0.0135 0.029 0.0286
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.0435 0.3647
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0045 0.0076 0.0289
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.0042 0.0314
Brugia malayi nuclear receptor NHR-88 0.0095 0.0196 0.0792
Onchocerca volvulus 0.0046 0.0079 0.0626
Trypanosoma cruzi hypothetical protein, conserved 0.0188 0.0417 1
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0042 0.1295
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0031 0.0042 0.0151
Brugia malayi Aldehyde dehydrogenase protein 4 0.0018 0.0011 0.0037
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0135 0.0291 0.1696
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0232
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0349 0.0344
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.0042 0.0314
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0135 0.029 0.2423
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0499
Echinococcus multilocularis tar DNA binding protein 0.0193 0.0428 0.0423
Echinococcus granulosus expressed conserved protein 0.0097 0.0199 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0077 0.0606
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0138 0.0542
Leishmania major aldehyde dehydrogenase, putative 0.0018 0.0011 0.0082
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.002 0.0017 0.007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0058 0.0184
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0007 0.0008
Echinococcus multilocularis apoptotic protease activating factor 1 0.0148 0.0321 0.0316
Echinococcus multilocularis ecdysone induced protein 78C 0.0095 0.0196 0.0191
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.0017 0.006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0246 0.0555 0.467
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0011 0.0147
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0031 0.0042 0.0897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0474 0.1099 0.6496
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0126 0.0268 0.1075
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0095 0.0196 0.0781
Loa Loa (eye worm) hypothetical protein 0.0095 0.0196 0.0781
Trichomonas vaginalis glucosylceramidase, putative 0.0246 0.0555 0.467
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0057 0.018
Echinococcus multilocularis beta LACTamase domain containing family member 0.0188 0.0417 0.0412
Onchocerca volvulus Protein ultraspiracle homolog 0.0095 0.0196 0.1619
Loa Loa (eye worm) cysteine protease 0.0016 0.0007 0.0008
Trypanosoma brucei metacaspase 0.0135 0.029 0.6925
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0008
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0018 0.0011 0.0037
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0008
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0067 0.0127 0.1644
Schistosoma mansoni GTP-binding protein alpha subunit 0.002 0.0017 0.007
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.0042 0.0499
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.005 0.0088 0.0495
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0135 0.029 0.3849
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0048
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0018 0.0011 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0095 0.0196 0.1132
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.004 0.0477
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0067 0.0127 0.0387
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0005 0.0016
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0076 0.0071
Echinococcus multilocularis carbonyl reductase 1 0.0031 0.0042 0.0037
Echinococcus granulosus inositol monophosphatase 1 0.0071 0.0137 0.0542
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0011 0.0036
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0058 0.045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0056 0.03
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0058 0.1286
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0095 0.0196 0.0191
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Loa Loa (eye worm) hypothetical protein 0.0135 0.029 0.1168
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0448 0.1035 0.4217
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0005 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Loa Loa (eye worm) hypothetical protein 0.0188 0.0417 0.1687
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.0323
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0045 0.0077 0.0963
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.012 0.0482
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0007 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0241 0.14
Echinococcus granulosus aryl hydrocarbon receptor 0.0046 0.0078 0.0298
Loa Loa (eye worm) CYP4Cod1 0.0125 0.0267 0.107
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0018 0.0011 0.0147
Mycobacterium leprae Probable oxidoreductase 0.0031 0.0042 0.0117
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0289
Schistosoma mansoni hypothetical protein 0.0064 0.012 0.0682
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0067 0.0127 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0116 0.2687
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0053 0.0405
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0069 0.0064
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.002 0.0017 0.007
Loa Loa (eye worm) fibroinase 0.0016 0.0007 0.0008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0094 0.0281
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0031 0.0042 0.0897
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0007 0.0068
Entamoeba histolytica G protein alpha subunit, putative 0.002 0.0017 0.0413
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.002 0.0017 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0053 0.1157
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0042 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0095 0.0196 0.0792
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0007 0.0012
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0031 0.0042 0.0117
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0042 0.0117
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.005 0.0088 0.0341
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0006 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0474 0.1099 0.4478
Onchocerca volvulus 0.0016 0.0007 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0161 0.0353 0.2957
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0067 0.0127 0.0403
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0428 0.2511
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0214 0.0854
Mycobacterium ulcerans short-chain dehydrogenase 0.0031 0.0042 0.0117
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0093 0.019 0.2497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0095 0.0196 0.0781
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0067 0.0127 0.0403
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0058 0.045
Brugia malayi nuclear receptor RXR 0.005 0.0088 0.0353
Brugia malayi Inositol-1 0.0071 0.0137 0.0553
Schistosoma mansoni RAR-like nuclear receptor 0.0095 0.0196 0.1132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0042 0.0163
Schistosoma mansoni inositol monophosphatase 0.0071 0.0137 0.0786
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0076 0.0289
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0151
Leishmania major oxidoreductase-like protein 0.0031 0.0042 0.0499
Onchocerca volvulus 0.0031 0.0042 0.0314
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0135 0.0291 0.118
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0031 0.0042 0.1295
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0067 0.0127 0.0387
Trypanosoma cruzi hypothetical protein, conserved 0.0188 0.0417 1
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.002 0.0017 0.007
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0017 0.01
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.0042 0.0314
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.002 0.0017 0.01

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.6 uM Inhibition of spontaneous tone in guinea pig tracheal spirals ChEMBL. 1875351
IC50 (functional) = 5.92 uM Inhibition of spontaneous tone in guinea pig tracheal spirals ChEMBL. 1875351
Intinsic activity (functional) = 0.84 Evaluated by measuring inhibition of spontaneous tone in guinea pig tracheal spirals ChEMBL. 1875351
Intinsic activity (functional) = 0.93 Evaluated by measuring inhibition of spontaneous tone in guinea pig tracheal spirals ChEMBL. 1875351

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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