Detailed view for Bm1_13830

Basic information

TDR Targets ID: 242860
Brugia malayi, eukaryotic initiation factor 4A
Source Database / ID:  GenBank

pI: 5.1172 | Length (AA): 413 | MW (Da): 46777 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00270   DEAD/DEAH box helicase
PF00271   Helicase conserved C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004386   helicase activity  
GO:0003676   nucleic acid binding  
GO:0008026   ATP-dependent helicase activity  
GO:0005524   ATP binding  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 412 5e7i (A) 140 574 29.00 0.021 1 1.28186 0
34 407 3eiq (A) 22 400 71.00 0 1 1.77827 -1.21
46 395 4kbf (A) 3 354 34.00 0 1 1.39516 -1.26
283 375 5lb3 (B) 263 355 23.00 0.031 1 0.644882 -1.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126984)

Species Accession Gene Product
Arabidopsis thaliana AT3G13920   translational initiation factor 4A-1
Arabidopsis thaliana AT1G54270   eukaryotic initiation factor 4A-2
Arabidopsis thaliana AT1G51380   DEAD-box ATP-dependent RNA helicase 34
Arabidopsis thaliana AT1G72730   eukaryotic initiation factor 4A-3
Babesia bovis BBOV_III010250   eukaryotic translation initiation factor 4A, putative
Brugia malayi Bm1_13830   eukaryotic initiation factor 4A
Candida albicans CaO19.10834   similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit
Candida albicans CaO19.3324   similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit
Caenorhabditis elegans CELE_F57B9.6   Protein INF-1, isoform B
Cryptosporidium hominis Chro.10108   eukaryotic initiation factor 4A (eIF4A) (eIF-4A)
Cryptosporidium parvum cgd1_880   eukaryotic initiation factor 4A (eIF4A) (eIF-4A)
Dictyostelium discoideum DDB_G0269146   DEAD/DEAH box helicase domain-containing protein
Drosophila melanogaster Dmel_CG9075   Eukaryotic initiation factor 4a
Escherichia coli b3162   ATP-dependent RNA helicase
Echinococcus granulosus EgrG_000666300   eukaryotic initiation factor 4A III
Echinococcus granulosus EgrG_000150000   eukaryotic initiation factor 4A
Entamoeba histolytica EHI_093900   DEAD/DEAH box helicase, putative
Echinococcus multilocularis EmuJ_000666300   eukaryotic initiation factor 4A III
Echinococcus multilocularis EmuJ_000150000   eukaryotic initiation factor 4A
Giardia lamblia GL50803_10255   Translation initiation factor eIF-4A, putative
Homo sapiens ENSG00000161960   eukaryotic translation initiation factor 4A1
Homo sapiens ENSG00000156976   eukaryotic translation initiation factor 4A2
Leishmania braziliensis LbrM.01.0740   eukaryotic initiation factor 4a, putative
Leishmania donovani LdBPK_010790.1   Eukaryotic initiation factor 4A-1
Leishmania infantum LinJ.01.0790   eukaryotic initiation factor 4a, putative
Leishmania infantum LinJ.01.0800   eukaryotic initiation factor 4a, putative
Leishmania major LmjF.01.0770   eukaryotic initiation factor 4a, putative
Leishmania major LmjF.01.0780   eukaryotic initiation factor 4a, putative
Leishmania mexicana LmxM.01.0770  
Loa Loa (eye worm) LOAG_02152   hypothetical protein
Mus musculus ENSMUSG00000022884   eukaryotic translation initiation factor 4A2
Mus musculus ENSMUSG00000059796   eukaryotic translation initiation factor 4A1
Mycobacterium tuberculosis Rv1253   Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)
Neospora caninum NCLIV_066310   DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related
Oryza sativa 4328286   Os02g0146600
Oryza sativa 4341966   Os06g0701100
Oryza sativa 4352769   Os12g0611200
Onchocerca volvulus OVOC1884   Eukaryotic initiation factor 4A homolog
Plasmodium berghei PBANKA_1331900   eukaryotic initiation factor 4a, putative
Plasmodium falciparum PF3D7_1468700   eukaryotic initiation factor 4A
Plasmodium knowlesi PKNH_1212500   eukaryotic initiation factor 4a, putative
Plasmodium vivax PVX_117030   RNA helicase-1, putative
Plasmodium yoelii PY04360   RNA helicase-1
Saccharomyces cerevisiae YKR059W   translation initiation factor eIF4A
Saccharomyces cerevisiae YJL138C   translation initiation factor eIF4A
Schistosoma japonicum Sjp_0008030   Eukaryotic initiation factor 4A-II, putative
Schistosoma japonicum Sjp_0207480   ATP-dependent RNA helicase eIF4A, putative
Schistosoma japonicum Sjp_0077800   Eukaryotic initiation factor 4A-III, putative
Schistosoma mansoni Smp_031010   DEAD box ATP-dependent RNA helicase
Schistosoma mansoni Smp_097660   DEAD box ATP-dependent RNA helicase
Schmidtea mediterranea mk4.037851.00  
Schmidtea mediterranea mk4.006461.00   Eukaryotic initiation factor 4A
Schmidtea mediterranea mk4.038251.00   Eukaryotic initiation factor 4A
Schmidtea mediterranea mk4.007524.00   Eukaryotic initiation factor 4A
Schmidtea mediterranea mk4.046988.00   Eukaryotic initiation factor 4A
Schmidtea mediterranea mk4.009693.00  
Schmidtea mediterranea mk4.002654.04  
Schmidtea mediterranea mk4.002625.00  
Schmidtea mediterranea mk4.019256.00  
Schmidtea mediterranea mk4.007573.00  
Schmidtea mediterranea mk4.015448.00   Eukaryotic initiation factor 4A
Schmidtea mediterranea mk4.003255.07   Eukaryotic initiation factor 4A
Trypanosoma brucei gambiense Tbg972.9.2490   eukaryotic initiation factor 4a, putative
Trypanosoma brucei Tb927.9.4680   Eukaryotic initiation factor 4A-1
Trypanosoma congolense TcIL3000_9_1560   eukaryotic initiation factor 4a, putative
Trypanosoma cruzi TcCLB.510155.180   Eukaryotic initiation factor 4A-1
Trypanosoma cruzi TcCLB.511585.190   Eukaryotic initiation factor 4A-1
Toxoplasma gondii TGME49_250770   eukaryotic initiation factor-4A, putative
Treponema pallidum TP0770   ATP-dependent RNA helicase
Theileria parva TP02_0123   RNA helicase-1, putative
Trichomonas vaginalis TVAG_209190   DEAD box ATP-dependent RNA helicase, putative
Trichomonas vaginalis TVAG_497090   DEAD box ATP-dependent RNA helicase, putative
Trichomonas vaginalis TVAG_380910   DEAD box ATP-dependent RNA helicase, putative

Essentiality

Bm1_13830 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.3270 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.160.3270 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.3270 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.160.3270 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3162 Escherichia coli non-essential goodall
CELE_F57B9.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F57B9.6 Caenorhabditis elegans larval arrest wormbase
CELE_F57B9.6 Caenorhabditis elegans slow growth wormbase
TGME49_250770 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens eukaryotic translation initiation factor 4A2 Compounds References
Mus musculus eukaryotic translation initiation factor 4A1 Compounds References
Hepatitis C virus Hepatitis C virus NS3 protease/helicase Compounds References
Hepatitis C virus genotype 1a (isolate H) (HCV) Genome polyprotein Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0697 0.389 1
0.04 0.8259 0.8259
0.0566 0.3562 0.7652
0.0116 0.3178 0.3691
0.0145 0.5927 1
0.00600017 0.272635 1
0.0556 0.448 0.5887
0.0644 0.8159 0.8346
0.0102 0.3266 0.3266
0.0442 0.669 0.669
0.013 0.3264 0.3264
0.079 0.3365 0.6809
0.01 0.37 0.37
0.0292 0.8259 1
0.0724 0.6854 0.6847
0.0124 0.3368 0.3597
0.0174 0.4667 0.5948
0.032 0.343 0.3419
0.0297 0.2634 0.2633
0.0727 0.6735 0.6735
0.0418 0.6279 0.6256
0.0513 0.4973 0.4968
0.0338 0.35 0.35
0.0424 0.4213 0.421
0.0077 0.5142 0.5142
0.0345 0.6326 1
0.0024 0.3995 0.2708
0.0149 0.3833 0.3833
0.0671 0.3102 0.3102
0.0325 0.6237 0.6497
0.0049 0.2581 0.2943
0.0698 0.6492 0.6484
0.0236 0.4947 0.7767
0.0334 0.3361 1
0.0338 0.35 0.35
0.01 0.2564 0.3025
0.0345 0.6326 1
0.0345 0.5208 0.8206
0.0207 0.8807 0.8807
0.0257 0.357 0.5573
0.0052 0.2623 0.2623
0.0674 0.774 1
0.0106 0.3567 0.3567
0.0152 0.5825 1
0.0671 0.3102 0.3102
0.0737 0.9406 1
0.0361 0.3745 0.9776
0.0519 0.4366 0.4365
0.01 0.383 0.383
0.0454 0.9324 0.5
0.0424 0.8641 1
0.0262 0.2603 1
0.0709 0.3453 0.5
0.0274 0.2925 0.288
0.008 0.4751 1
0.0566 0.3562 0.7652
0.0324 0.2628 0.2786
0.0566 0.3562 0.7652
0.0789 0.5131 0.5852
0.0793 0.7496 0.7493
0.0701 0.6585 0.6577
0.01 0.3702 0.3702
0.0566 0.3562 0.7652
0.0827 0.2956 0.2956
0.0223 0.4481 1
0.0105 0.8007 0.7997
0.0671 0.3102 0.3102
0.0097 0.5251 0.5197
0.0196 0.3926 1
0.01 0.2665 0.2665
0.0204 0.4115 0.6478
0.0339 0.9089 1
0.0078 0.6989 0.6989
0.0124 0.3301 0.3927
0.0121 0.5247 1
0.0128 0.8127 0.9966
0.0223 0.4481 1
0.0634 0.377 0.377
0.0674 0.774 1
0.0133 0.2685 0.5523
0.0126 0.3912 1
0.0189 0.6678 0.6678
0.0519 0.4366 0.4365
0.0101 0.2797 0.2797
0.0264 0.5496 0.8918
0.071 0.7875 1
0.0121 0.5247 1
0.079 0.3365 0.6809
0.0254 0.7119 1
0.0121 0.4383 1
0.0566 0.3562 0.7652
0.0745 0.2787 0.2887
0.0171 0.4088 1
0.0312 0.9393 1
0.0101 0.2559 0.2839
0.0395 0.2875 0.3001
0.011 0.3437 0.3437
0.0257 0.357 0.5573
0.0254 0.5243 0.7769
0.0348 0.5802 0.5802
0.0699 0.6417 0.6417
0.0114 0.3694 0.3694
0.0097 0.3574 0.3574
0.0199 0.8014 0.8005
0.0264 0.5496 0.8918
0.0754 0.7075 0.7075
0.079 0.3365 0.6809
0.0195 0.8323 0.9663
0.01 0.383 0.383
0.0072 0.2773 0.4064
0.0737 0.9406 1
0.0674 0.774 1
0.0789 0.5131 0.5852
0.0024 0.8743 0.8743
0.0359 0.8911 1
0.0127 0.4877 1
0.0276 0.4655 1
0.0311 0.4453 0.4433
0.0573 0.8127 1
0.2851 0.4733 0.4733
0.0596 0.8367 1
0.0106 0.3698 0.3698
0.0489 0.4918 1
0.064 0.4902 1
0.035 0.315 0.315
0.0317 0.3091 0.6449
0.0303 0.8373 1
0.0566 0.3562 0.7652
0.0345 0.5208 0.8206
0.0278 0.3399 0.4659
0.0122 0.2889 0
0.0699 0.6417 0.6417
0.0424 0.4213 0.421
0.0212 0.7694 0.7694
0.0321 0.2786 0.2609
0.0067 0.5537 1
0.0165 0.2634 1
0.0361 0.3745 0.9776
0.0102 0.383 0.383
0.011 0.3437 0.3437
0.0072 0.4877 0.561
0.0025 0.4782 0.4782
0.013 0.3264 0.3264
0.0128 0.3096 0.5214
0.0139 0.9117 0.5
0.0114 0.3694 0.3694
0.0635 0.739 1
0.0098 0.3702 0.3702
0.0661 0.7207 1
0.0101 0.5353 0.5353
0.0278 0.3399 0.4659
0.0634 0.377 0.377
0.0338 0.35 0.35
0.0303 0.4186 1
0.0128 0.8127 0.9966
0.0566 0.3562 0.7652
0.0177 0.619 0.6361
0.0264 0.5496 0.8918
0.079 0.4499 0.5
0.0614 0.6146 1
0.0187 0.6871 0.705
0.0291 0.8197 0.7767
0.0096 0.3741 0.4303
0.0176 0.7799 0.9762
0.0076 0.308 1
0.0395 0.2875 0.3001
0.0417 0.2918 1
0.003 0.3966 0.8913
0.0257 0.357 0.5573
0.0278 0.3399 0.4659
0.0105 0.6384 0.6384
0.1804 0.2909 0.2909
0.0099 0.3855 0.3706
0.0148 0.499 0.5711
0.0337 0.7159 1
0.0076 0.4751 1
0.0286 0.3493 0
0.0127 0.6734 0.6734
0.0101 0.3831 0.3831
0.0586 0.4086 1
0.0124 0.3368 0.3597
0.0703 0.6478 0.6472
0.0379 0.3761 0.7914
0.0192 0.6775 1
0.0264 0.5496 0.8918
0.0077 0.4923 0.4923
0.015 0.4641 0.5678
0.0155 0.2552 1
0.0692 0.6447 0.644
0.0072 0.4877 0.561
0.0167 0.3471 0.3515
0.0027 0.4828 0.4828
0.0125 0.2848 0.4124
0.0279 0.696 1
0.0086 0.5556 0.736
0.0789 0.5131 0.5852
0.0519 0.4366 0.4365
0.0205 0.3624 0.3624
0.0125 0.3615 0.4826
0.079 0.4499 0.5
0.0258 0.464 0.4625
0.0707 0.5258 0.5467
0.0698 0.6373 0.6373
0.012 0.2996 0.3816
0.0154 0.2827 0.4236
0.0178 0.4601 1
0.0148 0.5393 0.5
0.0441 0.3004 0.4053
0.0258 0.9268 1
0.0097 0.3823 0.3823
0.0789 0.5131 0.5852
0.0417 0.2918 1
0.0196 0.6 0.4864
0.0083 0.9531 0.9531
0.0074 0.4035 0.4035
0.0593 0.6427 1
0.0376 0.3002 0.2997
0.0108 0.3564 0.3564
0.0737 0.9406 1
0.0573 0.8127 1
0.0069 0.8108 0.7935
0.079 0.3365 0.6809
0.0436 0.4428 1
0.0102 0.383 0.383
0.0291 0.2526 0.2526
0.0595 0.3549 0.9917
0.0593 0.6427 1
0.0144 0.9833 1
0.0338 0.35 0.35
0.0128 0.4283 0.4228
0.0318 0.4102 1
0.0028 0.5069 0.5069
0.0148 0.4005 0.4717
0.0212 0.3752 0.3752
0.0129 0.6843 0.6843
0.0595 0.3549 0.9917
0.0123 0.3916 0.3916
0.0141 0.4273 0.4273
0.0789 0.5131 0.5852
0.0698 0.6563 0.6561
0.01 0.383 0.383
0.0425 0.3479 0.6407
0.012 0.5066 0.5066
0.0171 0.6798 0.6654
0.0107 0.3565 0.3565
0.0075 0.4384 0.4384
0.0441 0.3004 0.4053
0.071 0.7875 1
0.0329 0.8163 1
0.0148 0.5393 0.5
0.04 0.3241 0.3241
0.0591 0.2976 1
0.0566 0.3562 0.7652
0.0297 0.2634 0.2633
0.0128 0.3096 0.5214
0.0778 0.5716 1
0.0324 0.3056 1
0.0338 0.35 0.35
0.0072 0.4877 0.561
0.0441 0.3004 0.4053
0.0317 0.5615 1
0.0361 0.3745 0.9776
0.0441 0.3004 0.4053
0.0254 0.7119 1
0.079 0.4499 0.5
0.0133 0.2685 0.5523
0.0147 0.4373 0.8771
0.0055 0.9752 0.9752
0.0361 0.3745 0.9776
0.0199 0.552 0.5631
0.0303 0.4186 1
0.0102 0.5273 0.5273
0.0029 0.4655 0.3025
0.0262 0.8185 0.8185
0.0754 0.7075 0.7075
0.0724 0.6854 0.6847
0.0052 0.2623 0.2623
0.0393 0.5178 0.4028
0.0671 0.3102 0.3102
0.0674 0.774 1
0.0445 0.4471 1
0.0395 0.2875 0.3001
0.0278 0.3399 0.4659
0.0789 0.5131 0.5852
0.0221 0.2542 1
0.0398 0.4015 1
0.0257 0.357 0.5573
0.0448 0.5673 1
0.079 0.4499 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Bm1_13830 (Brugia malayi), eukaryotic initiation factor 4A
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