Detailed view for Rv1905c

Basic information

TDR Targets ID: 981912
Mycobacterium tuberculosis, Probable D-amino acid oxidase Aao
Source Database / ID:  Tuberculist 

pI: 5.9629 | Length (AA): 320 | MW (Da): 34076 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 320 1c0p (A) 1004 1355 30.00 0 1 1.2717 -0.51
5 317 1c0p (A) 1004 1352 35.00 0 1 1.17083 -0.02
7 319 4qfc (B) 2 332 29.00 0 1 1.36433 -0.72
7 318 4qfc (B) 2 331 32.00 0 1 1.3967 -0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127583)

Species Accession Gene Product
Candida albicans CaO19.10583   D-amino acid oxidase
Candida albicans CaO19.8559   putative d-amino acid oxidase
Candida albicans CaO19.3065   D-amino acid oxidase
Candida albicans CaO19.944   putative d-amino acid oxidase
Caenorhabditis elegans CELE_F18E3.7   Protein DDO-2, isoform B
Caenorhabditis elegans CELE_Y69A2AR.5   Protein DAAO-1
Caenorhabditis elegans CELE_C47A10.5   Protein DDO-1, isoform B
Dictyostelium discoideum DDB_G0273783   D-amino-acid:oxygen oxidoreductase
Dictyostelium discoideum DDB_G0273291   D-amino-acid:oxygen oxidoreductase
Drosophila melanogaster Dmel_CG12338   CG12338 gene product from transcript CG12338-RB
Drosophila melanogaster Dmel_CG11236   CG11236 gene product from transcript CG11236-RA
Homo sapiens ENSG00000203797   D-aspartate oxidase
Homo sapiens ENSG00000110887   D-amino-acid oxidase
Loa Loa (eye worm) LOAG_03943   hypothetical protein
Mycobacterium leprae ML2011   PROBABLE D-AMINO ACID OXIDASE AAO
Mus musculus ENSMUSG00000042096   D-amino acid oxidase
Mus musculus ENSMUSG00000063428   D-aspartate oxidase
Mycobacterium tuberculosis Rv1905c   Probable D-amino acid oxidase Aao
Mycobacterium ulcerans MUL_2926   D-amino acid oxidase Aao
Schistosoma japonicum Sjp_0008140   ko:K00272 D-aspartate oxidase [EC1.4.3.1], putative
Schistosoma mansoni Smp_170430   d-amino acid oxidase
Schmidtea mediterranea mk4.003324.03   D-amino-acid oxidase
Schmidtea mediterranea mk4.000344.03   D-amino-acid oxidase
Schmidtea mediterranea mk4.000344.09   D-amino-acid oxidase

Essentiality

Rv1905c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F18E3.7 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus D-amino-acid oxidase Compounds References
Homo sapiens D-amino-acid oxidase Compounds References
Rattus norvegicus D-aspartate oxidase Compounds References
Sus scrofa D-amino-acid oxidase Compounds References
Homo sapiens D-aspartate oxidase Compounds References
Mus musculus D-aspartate oxidase Compounds References
Mus musculus D-amino acid oxidase Compounds References
Bos taurus D-aspartate oxidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0144 0.3803 0.5
0.0336 0.6253 0.5
0.0536 0.9113 1
0.0923 0.9138 1
0.0144 0.3761 0.5
0.2825 0.9097 1
0.1678 0.3291 1
0.0325 0.9147 1
0.044 0.8756 0.5
0.0308 0.3734 0.5
0.0159 0.4511 1
0.1089 0.9155 1
0.0179 0.7623 0.762
0.0299 0.9091 1
0.0814 0.8819 0.5
0.0143 0.8895 1
0.1293 0.3779 1
0.0292 0.9147 1
0.0154 0.297 0.5
0.3757 0.9044 0.5
0.0659 0.9152 1
0.0143 0.9023 1
0.0154 0.2967 1
0.1095 0.3683 1
0.0179 0.57 1
0.045 0.7668 1
0.0602 0.9137 1
0.2175 0.9165 1
0.045 0.7663 1
0.0146 0.5934 0.5
0.045 0.7663 1
0.0127 0.7978 1
0.0536 0.6129 1
0.0602 0.6164 1
0.0179 0.9091 1
0.0287 0.8823 1
0.2314 0.9076 0.5
0.0778 0.9157 1
0.0179 0.9091 1
0.1313 0.9126 1
0.1205 0.8796 1
0.0172 0.3259 1
0.1089 0.9155 1
0.0536 0.9128 1
0.3355 0.9164 1
0.5317 0.4975 0.5
0.0149 0.6252 1
0.2369 0.8992 0.5
0.1632 0.9163 1
0.0162 0.9119 1
0.0927 0.9145 1
0.0287 0.8823 1
0.3355 0.9164 1
0.1273 0.6489 1
0.015 0.3903 1
0.1811 0.9161 1
0.3757 0.9044 0.5
0.2775 0.9162 1
0.1089 0.9155 1
0.0292 0.9147 1
0.3918 0.9164 1
0.0179 0.9081 1
0.1089 0.9155 1
0.1811 0.9161 1
0.045 0.7663 1
0.0291668 0.946981 1
0.0466 0.9087 1
0.0296 0.9106 1
0.3853 0.903 0.5
0.0179 0.9091 1
0.0159 0.4519 0.5755
0.0779 0.566 1
0.0482 0.4453 0.4973
0.0536 0.6129 1
0.4482 0.9163 1
0.045 0.7663 1
0.2418 0.9163 1
0.0444 0.6207 1
0.0309 0.3612 0.5
0.0154 0.4442 1
0.0452 0.9141 1
0.1622 0.9161 1
0.048 0.9103 1
0.1095 0.3683 1
0.0457 0.6311 1
0.031 0.3875 1
0.0159 0.4467 1
0.0162 0.3428 0.5
0.0144 0.3803 0.5
0.4681 0.3121 1
0.2825 0.9097 1
0.0292 0.8611 0.5
0.1089 0.9155 1
0.1441 0.9149 1
0.187 0.9153 1
0.1708 0.8994 1
0.0144 0.6048 0.5
0.1089 0.9155 1
0.0655 0.7976 1
0.0466 0.9087 1
0.0571 0.8179 1
0.0154 0.297 0.5
0.5039 0.9122 1
0.124 0.9152 1
0.0306 0.9027 0.5
0.2414 0.9163 1
0.187 0.9153 1
0.0583 0.9157 1
0.0149 0.5389 1
0.0459 0.7683 1
0.0447 0.5578 1
0.0536 0.6129 1
0.0633 0.8245 1
0.0179 0.913 1
0.1437 0.9163 1
0.3355 0.9164 1
0.0163 0.4219 0.5
0.1879 0.8806 0.5
0.0979 0.9117 1
0.0179 0.4875 0.5
0.1832 0.9141 1
0.0306 0.8137 1
0.1915 0.9155 1
0.0745 0.8907 0.8861
0.0778 0.9157 1
0.045 0.7663 1
0.0444 0.6331 1
0.082 0.8365 1
0.0433 0.9141 1
0.4514 0.9154 1
0.0735 0.9099 1
0.124 0.9152 1
0.1293 0.3779 1
0.0309 0.9119 1
0.0291668 0.946981 1
0.1063 0.8535 1
0.0149 0.5389 1
0.0622 0.812 1
0.0162 0.3428 0.5
0.0536 0.9161 1
0.3709 0.916 1
0.0452 0.4693 1
0.0633 0.8245 1
0.1095 0.3683 1
0.0148 0.9002 0.5
0.0602 0.8964 0.5
0.2752 0.9155 1
0.0143 0.8895 1
0.0179 0.896 0.5
0.0306 0.9027 0.5
0.0357 0.4297 0.5
0.1708 0.8994 1
0.1297 0.9161 1
0.048 0.9103 1
0.0335 0.9115 1
0.0291668 0.946981 1
0.0147 0.5385 1
0.0477 0.5704 1
0.0432 0.6339 1
0.1093 0.9163 1
0.2232 0.9151 1
0.0165 0.2797 1
0.1678 0.3291 1
0.0357 0.9033 0.5
0.4264 0.4056 1
0.0453 0.915 1
0.0179 0.5984 0.5
0.1879 0.8806 0.5
0.413 0.5794 1
0.1999 0.916 1
0.1043 0.9161 1
0.0145 0.2524 0.2522
0.1463 0.9159 1
0.0714 0.2684 1
0.0893 0.9159 1
0.0482 0.4453 0.4973
0.2379 0.9164 1
0.0948 0.916 1
0.0925 0.9126 1
0.413 0.5794 1
0.1127 0.9151 1
0.3355 0.9164 1
0.1366 0.912 1
0.3809 0.9158 1
0.1095 0.3683 1
0.0536 0.3014 1
0.0147 0.5385 1
0.2375 0.9101 1
0.1246 0.9162 1
0.187 0.9153 1
0.1095 0.3683 1
0.2172 0.9163 1
0.0444 0.5285 1
0.2418 0.9163 1
0.0291668 0.946981 1
0.0322 0.9099 1
0.0791 0.9104 1
0.0792 0.7475 1
0.0357 0.9125 1
0.1093 0.9163 1
0.0645 0.8217 1
0.2138 0.9164 1
0.1832 0.9138 1
0.048 0.8623 0.5
0.0149 0.6369 0.6369
0.0432 0.4727 0.5
0.1293 0.3779 1
0.3882 0.9162 1
0.1293 0.3779 1
0.2379 0.9164 1
0.1529 0.9163 1
0.1861 0.9151 1
0.3524 0.9091 1
0.1353 0.9162 1
0.0357 0.9091 1
0.0314 0.9057 0.5
0.2172 0.9163 1
0.0145 0.4435 0.5698
0.1291 0.9156 1
0.0578 0.912 1
0.0179 0.712 0.6868
0.1095 0.3683 1
0.0172 0.3259 1
0.1205 0.8796 1
0.0457 0.6352 1
0.0468 0.9068 0.5
0.1277 0.9153 1
0.1478 0.9164 1
0.6997 0.9091 1
0.0536 0.9143 1
0.2829 0.9154 1
0.106 0.9136 1
0.1697 0.9106 1
0.0536 0.8985 0.5
0.0291668 0.946981 1
0.0357 0.9053 0.5
0.046 0.6069 0.8824
0.1468 0.9165 1
0.0911 0.9153 1
0.2045 0.9164 1
0.0575 0.6663 0.5
0.0291668 0.946981 1
0.05 0.286 1
0.0179 0.2674 0.5
0.0578 0.7451 1
0.0317 0.3625 1
0.2175 0.9165 1
0.2652 0.9164 1
0.0154 0.4501 1
0.3533 0.9161 1
0.0144 0.3725 0.5
0.1063 0.8535 1
0.3355 0.9164 1
0.0602 0.6164 1
0.0336 0.6253 0.5
0.0603 0.9091 1
0.0357 0.9138 1
0.0287 0.9139 1
0.0298 0.8981 0.5
0.0602 0.6164 1
0.0457 0.6311 1
0.0624 0.7619 1
0.1861 0.9151 1
0.0536 0.8987 0.5
0.0602 0.9137 1
0.0792 0.7475 1
0.0291668 0.946981 1
0.0571 0.8179 1
0.045 0.7662 1
0.3462 0.9062 0.5
0.0536 0.9154 1
0.0446 0.9126 1
0.0179 0.8891 1
0.0179 0.8766 0.5
0.0454 0.915 1
0.0584 0.9141 1
0.0179 0.6257 1
0.0432 0.6283 1
0.1095 0.3683 1
0.1586 0.913 1
0.0452 0.4693 1
0.0179 0.9003 0.5
0.0536 0.9154 1
0.0144 0.6119 0.5
0.0172 0.3259 1
0.0145 0.5533 1
0.0536 0.6129 1
0.0172 0.3227 1
0.0302 0.9147 1
0.0159 0.4456 1
0.0448 0.737 1
0.0308 0.8371 0.5
0.1146 0.9152 1
0.3533 0.9161 1
0.0287 0.9091 1
0.0357 0.9151 1
0.0591 0.901 0.5
0.1069 0.8627 0.5
0.2349 0.9124 1
0.1915 0.9155 1
0.4044 0.9085 0.5
0.0163 0.653 1
0.0306 0.8137 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv1905c (Mycobacterium tuberculosis), Probable D-amino acid oxidase Aao
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