pI: 8.2819 |
Length (AA): 491 |
MW (Da): 50988 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
18 | 428 | 5lm4 (A) | 42 | 486 | 22.00 | 0.15 | 1 | 1.05637 | -0.06 |
20 | 426 | 5dwy (A) | 8 | 427 | 30.00 | 0 | 1 | 1.19392 | -0.63 |
22 | 428 | 5lm4 (A) | 46 | 486 | 28.00 | 0 | 0.92 | 1.09162 | 0 |
26 | 418 | 2nwl (A) | 12 | 415 | 31.00 | 0 | 1 | 1.13941 | -0.38 |
71 | 207 | 3llq (A) | 13 | 148 | 32.00 | 0.044 | 0.04 | 0.220722 | 1.63 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Dormant phase. | hasan |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase. | murphy |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_126739)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_42930 | Excitatory amino acid transporter |
Caenorhabditis elegans | CELE_C12D12.2 | Protein GLT-1, isoform B |
Caenorhabditis elegans | CELE_Y53C12A.2 | Protein GLT-5 |
Caenorhabditis elegans | CELE_T22E5.2 | Protein GLT-4 |
Caenorhabditis elegans | CELE_R05G6.6 | Protein GLT-6 |
Chlamydia trachomatis | CT_401 | glutamate symporter |
Drosophila melanogaster | Dmel_CG3747 | Excitatory amino acid transporter 1 |
Drosophila melanogaster | Dmel_CG3159 | Excitatory amino acid transporter 2 |
Escherichia coli | b3528 | C4-dicarboxylic acid, orotate and citrate transporter |
Escherichia coli | b4077 | glutamate/aspartate:proton symporter |
Echinococcus granulosus | EgrG_000819900 | Excitatory amino acid transporter |
Echinococcus granulosus | EgrG_000812100 | excitatory amino acid transporter 2 |
Echinococcus granulosus | EgrG_000820100 | Excitatory amino acid transporter |
Echinococcus granulosus | EgrG_000469500 | sodium:dicarboxylate symporter |
Echinococcus granulosus | EgrG_000751200 | neutral amino acid transporter |
Echinococcus granulosus | EgrG_001182500 | excitatory amino acid transporter 3 |
Echinococcus granulosus | EgrG_001168200 | neutral amino acid transporter A |
Echinococcus granulosus | EgrG_000668500 | excitatory amino acid transporter 2 |
Echinococcus granulosus | EgrG_001168300 | neutral amino acid transporter A |
Echinococcus multilocularis | EmuJ_000751200 | neutral amino acid transporter excitatory amino acid transporter |
Echinococcus multilocularis | EmuJ_001168200 | neutral amino acid transporter A |
Echinococcus multilocularis | EmuJ_001168100 | neutral amino acid transporter A |
Echinococcus multilocularis | EmuJ_000469500 | sodium:dicarboxylate symporter |
Echinococcus multilocularis | EmuJ_001182500 | excitatory amino acid transporter 3 |
Echinococcus multilocularis | EmuJ_001168300 | neutral amino acid transporter A |
Echinococcus multilocularis | EmuJ_000668500 | excitatory amino acid transporter 2 |
Echinococcus multilocularis | EmuJ_000820100 | Excitatory amino acid transporter |
Echinococcus multilocularis | EmuJ_000819900 | Excitatory amino acid transporter |
Echinococcus multilocularis | EmuJ_000812100 | excitatory amino acid transporter 2 |
Homo sapiens | ENSG00000105143 | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 |
Homo sapiens | ENSG00000106688 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
Homo sapiens | ENSG00000105281 | solute carrier family 1 (neutral amino acid transporter), member 5 |
Homo sapiens | ENSG00000079215 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
Homo sapiens | ENSG00000110436 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
Loa Loa (eye worm) | LOAG_07869 | excitatory amino acid transporter |
Mus musculus | ENSMUSG00000024935 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
Mus musculus | ENSMUSG00000020142 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 |
Mus musculus | ENSMUSG00000005360 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
Mus musculus | ENSMUSG00000001918 | solute carrier family 1 (neutral amino acid transporter), member 5 |
Mus musculus | ENSMUSG00000005357 | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 |
Mus musculus | ENSMUSG00000005089 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
Mycobacterium tuberculosis | Rv2443 | Probable C4-dicarboxylate-transport transmembrane protein DctA |
Onchocerca volvulus | OVOC9973 | Excitatory amino acid transporter homolog |
Schistosoma japonicum | Sjp_0123600 | Excitatory amino acid transporter 2, putative |
Schistosoma japonicum | Sjp_0037260 | ko:K05613 solute carrier family 1 (glial high affinity glutamate transporter),, putative |
Schistosoma japonicum | Sjp_0037270 | ko:K05614 solute carrier family 1 (glial high affinity glutamate transporter),, putative |
Schistosoma mansoni | Smp_016600 | solute carrier family 1 (glial high affinity glutamate transporter |
Schmidtea mediterranea | mk4.004152.01 | |
Schmidtea mediterranea | mk4.001719.05 | |
Schmidtea mediterranea | mk4.010462.02 | |
Schmidtea mediterranea | mk4.044600.00 | Sodium/dicarboxylate symporter-related |
Schmidtea mediterranea | mk4.016506.00 | Excitatory amino acid transporter 2 |
Schmidtea mediterranea | mk4.004152.00 | |
Theileria parva | TP04_0725 | glutamate transporter, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0789 | Na+/H+-dicarboxylate symporter |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2486 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
b3528 | Escherichia coli | non-essential | goodall |
b4077 | Escherichia coli | non-essential | goodall |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Excitatory amino acid transporter 1 | Compounds | References |
Rattus norvegicus | Excitatory amino acid transporter 3 | Compounds | References |
Homo sapiens | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | Compounds | References |
Homo sapiens | solute carrier family 1 (neutral amino acid transporter), member 5 | Compounds | References |
Homo sapiens | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | Compounds | References |
Homo sapiens | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | Compounds | References |
Rattus norvegicus | Amino acid transporter | Compounds | References |