pI: 7.7595 |
Length (AA): 378 |
MW (Da): 43679 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
43 | 375 | 5az0 (A) | 4 | 344 | 33.00 | 0.00000068 | 1 | 1.26145 | -0.59 |
47 | 365 | 1us0 (A) | 3 | 313 | 35.00 | 0 | 1 | 1.37942 | -1.34 |
47 | 365 | 4gac (A) | 5 | 323 | 46.00 | 0 | 1 | 1.44492 | -1.16 |
50 | 365 | 1ah4 (A) | 6 | 313 | 42.00 | 0 | 1 | 1.41998 | -1.19 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126583)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G37760 | aldo-keto reductase family 4 member C8 |
Arabidopsis thaliana | AT2G21250 | putative NADPH dependent mannose 6-phosphate reductase |
Arabidopsis thaliana | AT2G21260 | putative mannose-6P reductase |
Arabidopsis thaliana | AT2G37770 | aldo-keto reductase family 4 member C9 |
Arabidopsis thaliana | AT5G01670 | putative aldose reductase |
Arabidopsis thaliana | AT2G37790 | aldo-keto reductase family 4 member C10 |
Arabidopsis thaliana | AT3G53880 | aldo-keto reductase family 4 member C11 |
Brugia malayi | Bm1_38415 | oxidoreductase, aldo/keto reductase family protein |
Brugia malayi | Bm1_31490 | oxidoreductase, aldo/keto reductase family protein |
Brugia malayi | Bm1_43535 | oxidoreductase, aldo/keto reductase family protein |
Brugia malayi | Bm1_28070 | oxidoreductase, aldo/keto reductase family protein |
Candida albicans | CaO19.6758 | similar to mammalian aldo/keto reductases |
Candida albicans | CaO19.14108 | see also nonallelic CaP19.2244 |
Candida albicans | CaO19.14050 | similar to mammalian aldo/keto reductases |
Candida albicans | CaO19.4317 | Aldose reductase |
Candida albicans | CaO19.6816 | see also nonallelic CaP19.2244 |
Candida albicans | CaO19.6757 | similar to mammalian aldo/keto reductases |
Candida albicans | CaO19.11792 | Aldose reductase |
Candida albicans | CaO19.14049 | similar to mammalian aldo/keto reductases |
Caenorhabditis elegans | CELE_F53F1.2 | Protein F53F1.2 |
Caenorhabditis elegans | CELE_C01G5.5 | Protein C01G5.5 |
Caenorhabditis elegans | CELE_ZC443.1 | Protein ZC443.1 |
Caenorhabditis elegans | CELE_Y39G8B.1 | Protein Y39G8B.1, isoform A |
Caenorhabditis elegans | CELE_ZK1290.5 | Protein ZK1290.5 |
Caenorhabditis elegans | CELE_T08H10.1 | Protein T08H10.1 |
Caenorhabditis elegans | CELE_C07D8.6 | Protein C07D8.6 |
Caenorhabditis elegans | CELE_C35D10.6 | Protein C35D10.6 |
Dictyostelium discoideum | DDB_G0285053 | aldo-keto reductase |
Dictyostelium discoideum | DDB_G0285025 | aldo-keto reductase |
Dictyostelium discoideum | DDB_G0285023 | aldo-keto reductase |
Dictyostelium discoideum | DDB_G0293850 | aldehyde reductase |
Dictyostelium discoideum | DDB_G0285027 | aldo-keto reductase |
Dictyostelium discoideum | DDB_G0268058 | aldo-keto reductase |
Drosophila melanogaster | Dmel_CG6083 | CG6083 gene product from transcript CG6083-RA |
Drosophila melanogaster | Dmel_CG6084 | CG6084 gene product from transcript CG6084-RC |
Drosophila melanogaster | Dmel_CG10863 | CG10863 gene product from transcript CG10863-RA |
Drosophila melanogaster | Dmel_CG9436 | CG9436 gene product from transcript CG9436-RA |
Drosophila melanogaster | Dmel_CG10638 | CG10638 gene product from transcript CG10638-RD |
Drosophila melanogaster | Dmel_CG12766 | CG12766 gene product from transcript CG12766-RA |
Escherichia coli | b1781 | aldo-keto reductase, methylglyoxal to acetol, NADPH-dependent |
Escherichia coli | b0207 | 2,5-diketo-D-gluconate reductase B |
Escherichia coli | b3012 | 2,5-diketo-D-gluconate reductase A |
Echinococcus granulosus | EgrG_000558000 | aldo keto reductase family 1 member B4 |
Echinococcus granulosus | EgrG_000156100 | hypothetical protein |
Echinococcus granulosus | EgrG_000155400 | aldo keto reductase family 1 member B4 |
Echinococcus granulosus | EgrG_000156400 | aldo keto reductase family 1 member B4 |
Echinococcus granulosus | EgrG_000155600 | aldo keto reductase family 1 member B4 |
Echinococcus granulosus | EgrG_001163800 | aldehyde reductase |
Echinococcus granulosus | EgrG_000523800 | aldo keto reductase family 1 member B4 |
Echinococcus granulosus | EgrG_000155500 | aldo keto reductase |
Echinococcus granulosus | EgrG_000155900 | aldo keto reductase family 1 member B4 |
Echinococcus granulosus | EgrG_000156300 | aldo keto reductase family 1 member B4 |
Echinococcus granulosus | EgrG_000110500 | aldo keto reductase |
Echinococcus granulosus | EgrG_000156200 | aldo keto reductase |
Echinococcus granulosus | EgrG_000787800 | aldo keto reductase family 1 member B4 |
Echinococcus granulosus | EgrG_001163200 | aldo keto reductase family 1 member B4 |
Entamoeba histolytica | EHI_178670 | aldose reductase, putative |
Entamoeba histolytica | EHI_039190 | aldose reductase, putative |
Entamoeba histolytica | EHI_029620 | aldose reductase, putative |
Echinococcus multilocularis | EmuJ_000155400 | aldo keto reductase family 1, member B4 |
Echinococcus multilocularis | EmuJ_000155900 | aldo keto reductase family 1, member B4 |
Echinococcus multilocularis | EmuJ_001163200 | aldo keto reductase family 1, member B4 |
Echinococcus multilocularis | EmuJ_000787800 | aldo keto reductase family 1, member B4 |
Echinococcus multilocularis | EmuJ_000156300 | aldo keto reductase family 1, member B4 |
Echinococcus multilocularis | EmuJ_000558000 | aldo keto reductase family 1, member B4 |
Echinococcus multilocularis | EmuJ_000156050 | aldo keto reductase |
Echinococcus multilocularis | EmuJ_000155500 | aldo keto reductase |
Echinococcus multilocularis | EmuJ_000156200 | aldo keto reductase |
Echinococcus multilocularis | EmuJ_000110500 | aldo keto reductase |
Echinococcus multilocularis | EmuJ_000156100 | aldo keto reductase family 1, member B4 |
Echinococcus multilocularis | EmuJ_000156400 | aldo keto reductase family 1, member B4 |
Echinococcus multilocularis | EmuJ_000523800 | aldo keto reductase family 1, member B4 |
Echinococcus multilocularis | EmuJ_000155600 | aldo keto reductase family 1, member B4 |
Echinococcus multilocularis | EmuJ_001163800 | aldehyde reductase |
Echinococcus multilocularis | EmuJ_000156000 | aldo keto reductase family 1, member B4 |
Giardia lamblia | GL50803_9008 | Aldose reductase |
Giardia lamblia | GL50803_7260 | Aldose reductase |
Homo sapiens | ENSG00000117448 | aldo-keto reductase family 1, member A1 (aldehyde reductase) |
Homo sapiens | ENSG00000122787 | aldo-keto reductase family 1, member D1 |
Homo sapiens | ENSG00000198074 | aldo-keto reductase family 1, member B10 (aldose reductase) |
Homo sapiens | ENSG00000085662 | aldo-keto reductase family 1, member B1 (aldose reductase) |
Leishmania braziliensis | LbrM.27.2620 | aldo-keto reductase-like protein |
Leishmania braziliensis | LbrM.32.0530 | prostaglandin f synthase, putative |
Leishmania braziliensis | LbrM.31.3240 | aldehyde reductase, putative,oxidoreductase, putative |
Leishmania braziliensis | LbrM.31.2410 | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase |
Leishmania donovani | LdBPK_272360.1 | aldo-keto reductase-like protein |
Leishmania donovani | LdBPK_312980.1 | aldehyde reductase, putative |
Leishmania donovani | LdBPK_320470.1 | prostaglandin f synthase, putative |
Leishmania donovani | LdBPK_312210.1 | prostaglandin f2-alpha synthase |
Leishmania infantum | LinJ.31.2210 | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase |
Leishmania infantum | LinJ.27.2360 | aldo-keto reductase-like protein |
Leishmania infantum | LinJ.32.0470 | prostaglandin f synthase, putative |
Leishmania infantum | LinJ.31.2980 | aldehyde reductase, putative,oxidoreductase, putative |
Leishmania major | LmjF.31.2880 | aldehyde reductase, putative,oxidoreductase, putative |
Leishmania major | LmjF.27.2410 | aldo-keto reductase-like protein |
Leishmania major | LmjF.32.0460 | prostaglandin f synthase, putative |
Leishmania major | LmjF.31.2150 | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase |
Leishmania mexicana | LmxM.30.2880 | aldehyde reductase, putative,oxidoreductase, putative |
Leishmania mexicana | LmxM.31.0460 | prostaglandin f synthase, putative |
Leishmania mexicana | LmxM.27.2410 | aldo-keto reductase-like protein |
Leishmania mexicana | LmxM.30.2150 | prostaglandin f2-alpha synthase |
Loa Loa (eye worm) | LOAG_07850 | oxidoreductase |
Loa Loa (eye worm) | LOAG_14089 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00382 | oxidoreductase |
Loa Loa (eye worm) | LOAG_12297 | oxidoreductase |
Loa Loa (eye worm) | LOAG_07631 | oxidoreductase |
Loa Loa (eye worm) | LOAG_07633 | oxidoreductase |
Mycobacterium leprae | ML1669 | PROBABLE OXIDOREDUCTASE |
Mycobacterium leprae | ML1668B | Conserved hypothetical protein |
Mus musculus | ENSMUSG00000029762 | aldo-keto reductase family 1, member B8 |
Mus musculus | ENSMUSG00000071551 | aldo-keto reductase family 1, member C19 |
Mus musculus | ENSMUSG00000038641 | aldo-keto reductase family 1, member D1 |
Mus musculus | ENSMUSG00000061758 | aldo-keto reductase family 1, member B10 (aldose reductase) |
Mus musculus | ENSMUSG00000028692 | aldo-keto reductase family 1, member A1 (aldehyde reductase) |
Mus musculus | ENSMUSG00000052131 | aldo-keto reductase family 1, member B7 |
Mus musculus | ENSMUSG00000021207 | aldo-keto reductase family 1, member C21 |
Mus musculus | ENSMUSG00000001642 | aldo-keto reductase family 1, member B3 (aldose reductase) |
Mycobacterium tuberculosis | Rv2971 | Probable oxidoreductase |
Mycobacterium ulcerans | MUL_1987 | oxidoreductase |
Neospora caninum | NCLIV_033820 | Oxidoreductase, aldo/keto reductase family, related |
Oryza sativa | 4335054 | Os04g0167800 |
Oryza sativa | 4335974 | Os04g0447500 |
Oryza sativa | 4328139 | Os02g0123500 |
Oryza sativa | 4327475 | Os01g0847600 |
Oryza sativa | 4335975 | Os04g0447600 |
Oryza sativa | 4338987 | Os05g0456300 |
Oryza sativa | 4339090 | Os05g0474600 |
Oryza sativa | 4335976 | Os04g0447700 |
Oryza sativa | 4327476 | Os01g0847700 |
Oryza sativa | 9271397 | Os01g0847800 |
Onchocerca volvulus | OVOC7491 |
|
Onchocerca volvulus | OVOC7490 |
|
Onchocerca volvulus | OVOC7492 |
|
Onchocerca volvulus | OVOC12715 |
|
Onchocerca volvulus | OVOC4708 |
|
Onchocerca volvulus | OVOC12059 |
|
Saccharomyces cerevisiae | YOR120W | glycerol 2-dehydrogenase (NADP(+)) GCY1 |
Saccharomyces cerevisiae | YDR368W | trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 |
Saccharomyces cerevisiae | YJR096W | aldo-keto reductase superfamily protein |
Saccharomyces cerevisiae | YHR104W | trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) |
Schistosoma japonicum | Sjp_0217190 | ko:K00011 aldehyde reductase [EC1.1.1.21], putative |
Schistosoma japonicum | Sjp_0128820 | IPR001395,Aldo/keto reductase,domain-containing |
Schistosoma mansoni | Smp_053220.2 | aldo-keto reductase |
Schistosoma mansoni | Smp_150700 | pol-related |
Schistosoma mansoni | Smp_053220.1 | aldo-keto reductase |
Schmidtea mediterranea | mk4.001259.08 | Aldo-keto reductase family 1 member C-like protein 1 |
Schmidtea mediterranea | mk4.000349.02 | Aldo-keto reductase family 1 member C-like protein 1 |
Schmidtea mediterranea | mk4.020436.00 | |
Schmidtea mediterranea | mk4.015469.01 | |
Trypanosoma brucei gambiense | Tbg972.11.5340 | prostaglandin f synthase. putative |
Trypanosoma brucei gambiense | Tbg.972.2.3200 | aldo-keto reductase, putative |
Trypanosoma brucei | Tb927.11.4700 | prostaglandin f synthase |
Trypanosoma brucei | Tb927.2.5180 | aldo-keto reductase, putative |
Trypanosoma congolense | TcIL3000.11.4810 | prostaglandin f synthase, putative |
Trypanosoma congolense | TcIL3000_2_1280 | aldo-keto reductase, putative |
Trypanosoma cruzi | TcCLB.511287.49 | aldo-keto reductase |
Trypanosoma cruzi | TcCLB.511627.120 | aldo/keto reductase, putative |
Toxoplasma gondii | TGME49_273920 | aldose reductase, putative |
Trichomonas vaginalis | TVAG_080780 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_044820 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_506800 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_054660 | aldo/keto reductase, putative |
Trichomonas vaginalis | TVAG_562150 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_370500 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_348390 | dihydrodiol dehydrogenase, putative |
Trichomonas vaginalis | TVAG_175700 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_245190 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_495740 | dihydrodiol dehydrogenase, putative |
Trichomonas vaginalis | TVAG_048690 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_312310 | aldo/keto reductase, putative |
Trichomonas vaginalis | TVAG_602270 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_411870 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_007830 | aldo/keto reductase, putative |
Trichomonas vaginalis | TVAG_465230 | dihydrodiol dehydrogenase, putative |
Trichomonas vaginalis | TVAG_102160 | aldo-keto reductase, putative |
Trichomonas vaginalis | TVAG_090550 | aldo-keto reductase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.2310 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.2310 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.2310 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb11.02.2310 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.2.5180 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.5180 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.5180 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.2.5180 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0207 | Escherichia coli | non-essential | goodall |
b1781 | Escherichia coli | non-essential | goodall |
b3012 | Escherichia coli | non-essential | goodall |
CELE_F53F1.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F53F1.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C01G5.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_273920 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | aldo-keto reductase family 1, member B10 (aldose reductase) | Compounds | References |
Sus scrofa | Aldose reductase | Compounds | References |
Mus musculus | aldo-keto reductase family 1, member C21 | Compounds | References |
Homo sapiens | aldo-keto reductase family 1, member A1 (aldehyde reductase) | Compounds | References |
Sus scrofa | Aldehyde reductase | Compounds | References |
Rattus norvegicus | Aldose reductase-related protein 1 | Compounds | References |
Bos taurus | Aldose reductase | Compounds | References |
Rattus norvegicus | Aldehyde reductase | Compounds | References |
Homo sapiens | aldo-keto reductase family 1, member B1 (aldose reductase) | Compounds | References |
Rattus norvegicus | Aldose reductase | Compounds | References |