pI: 6.0605 |
Length (AA): 436 |
MW (Da): 46111 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 435 | 3tfu (A) | 7 | 433 | 86.00 | 0 | 1 | 1.99035 | -0.75 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Ortholog group members (OG5_128068)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G22200 | gamma-aminobutyrate transaminase POP2 |
Candida albicans | CaO19.11051 | second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase |
Candida albicans | CaO19.3567 | second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase |
Candida albicans | CaO19.10122 | adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria |
Candida albicans | CaO19.2591 | adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria |
Dictyostelium discoideum | DDB_G0290721 | aminotransferase class-III |
Escherichia coli | b0774 | 7,8-diaminopelargonic acid synthase, PLP-dependent |
Mycobacterium leprae | ML1216 | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA |
Mycobacterium tuberculosis | Rv3329 | Probable aminotransferase |
Mycobacterium tuberculosis | Rv1568 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA |
Mycobacterium ulcerans | MUL_1559 | adenosylmethionine-8-amino-7-oxononanoate aminotransferase |
Mycobacterium ulcerans | MUL_2791 | hypothetical protein |
Oryza sativa | 4328053 | Os02g0112900 |
Oryza sativa | 4336982 | Os04g0614500 |
Oryza sativa | 4344928 | Os08g0205900 |
Oryza sativa | 4336983 | Os04g0614600 |
Saccharomyces cerevisiae | YNR058W | adenosylmethionine-8-amino-7-oxononanoate transaminase |
Schmidtea mediterranea | mk4.074688.01 | |
Schmidtea mediterranea | mk4.027108.13 | |
Trichomonas vaginalis | TVAG_258770 | acetylornithine aminotransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1596 | Mycobacterium tuberculosis | non-essential | nmpdr |
b0774 | Escherichia coli | non-essential | goodall |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium tuberculosis | 0 527344 568456 | |
Annotator: | crowther@u.washington.edu. | Comment: | 2007-12-21. | References: | 16984394 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Compound | Source | Reference |
---|---|---|
Curated by TDRTargets | References | |
Curated by TDRTargets | References |
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | Compounds | References |
Target | Type | Source | Notes |
---|---|---|---|
ML1216 | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 1 ) |
1 literature reference was collected for this gene.