pI: 7.3927 |
Length (AA): 430 |
MW (Da): 50244 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
205 | 288 | 1uhr (A) | 8 | 91 | 58.00 | 0 | 1 | 1.00005 | -1.33 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127069)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G14170 | chromodomain remodeling complex protein CHC1 |
Arabidopsis thaliana | AT3G01890 | Swi/Snf complex component SWP73-like protein |
Brugia malayi | Bm1_44510 | brahma associated protein 60 kDa |
Brugia malayi | Bm1_38005 | Amiloride-sensitive sodium channel family protein |
Brugia malayi | Bm1_55005 | brahma associated protein 60 kDa |
Candida albicans | CaO19.9805 | subunit of SWI/SNF transcription activation complex |
Candida albicans | CaO19.2265 | subunit of SWI/SNF transcription activation complex |
Caenorhabditis elegans | CELE_T28F2.7 | Protein ACD-5 |
Caenorhabditis elegans | CELE_C18E3.2 | Protein SWSN-2.2 |
Caenorhabditis elegans | CELE_ZK1128.5 | Protein HAM-3 |
Cryptosporidium hominis | Chro.30113 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d3; Rsc6p |
Cryptosporidium parvum | cgd3_840 | RSC6/BAF60A ortholog with a SWIB domain |
Dictyostelium discoideum | DDB_G0273203 | CHC group protein |
Dictyostelium discoideum | DDB_G0273725 | CHC group protein |
Drosophila melanogaster | Dmel_CG10972 | pickpocket 12 |
Drosophila melanogaster | Dmel_CG4303 | Brahma associated protein 60kD |
Drosophila melanogaster | Dmel_CG3478 | pickpocket |
Echinococcus granulosus | EgrG_000613400 | SWI:SNF matrix associated |
Echinococcus multilocularis | EmuJ_000612800 | SWI:SNF matrix associated |
Echinococcus multilocularis | EmuJ_000613200 | SWI:SNF matrix associated |
Echinococcus multilocularis | EmuJ_000613400 | SWI:SNF matrix associated |
Homo sapiens | ENSG00000108684 | acid-sensing (proton-gated) ion channel 2 |
Homo sapiens | ENSG00000082014 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
Homo sapiens | ENSG00000110881 | acid-sensing (proton-gated) ion channel 1 |
Homo sapiens | ENSG00000066117 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 |
Homo sapiens | ENSG00000108604 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 |
Loa Loa (eye worm) | LOAG_02020 | brahma associated protein |
Loa Loa (eye worm) | LOAG_03801 | amiloride-sensitive sodium channel family protein |
Mus musculus | ENSMUSG00000028949 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
Mus musculus | ENSMUSG00000023018 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 |
Mus musculus | ENSMUSG00000020704 | acid-sensing (proton-gated) ion channel 2 |
Mus musculus | ENSMUSG00000078619 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 |
Mus musculus | ENSMUSG00000023017 | acid-sensing (proton-gated) ion channel 1 |
Oryza sativa | 4335638 | Os04g0382100 |
Onchocerca volvulus | OVOC4277 |
|
Saccharomyces cerevisiae | YNR023W | Snf12p |
Saccharomyces cerevisiae | YCR052W | Rsc6p |
Schistosoma japonicum | Sjp_0015370 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2, putative |
Schistosoma japonicum | Sjp_0119920 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1, putative |
Schistosoma mansoni | Smp_134310 | brg-1 associated factor |
Schmidtea mediterranea | mk4.000918.00 | Brahma-associated protein of 60 kDa |
Trichomonas vaginalis | TVAG_355010 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C18E3.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C18E3.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_ZK1128.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK1128.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_ZK1128.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_ZK1128.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_ZK1128.5 | Caenorhabditis elegans | sterile | wormbase |
YCR052W | Saccharomyces cerevisiae | inviable | yeastgenome |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | acid-sensing (proton-gated) ion channel 1 | Compounds | References |