Detailed view for Rv1568

Basic information

TDR Targets ID: 5713
Mycobacterium tuberculosis, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA
Source Database / ID:  Tuberculist 

pI: 6.25 | Length (AA): 437 | MW (Da): 46319 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00202   Aminotransferase class-III

Gene Ontology

Mouse over links to read term descriptions.
GO:0008483   transaminase activity  
GO:0004015   adenosylmethionine-8-amino-7-oxononanoate transaminase activity  
GO:0003824   catalytic activity  
GO:0030170   pyridoxal phosphate binding  
GO:0009102   biotin biosynthetic process  

Metabolic Pathways

Biotin metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 437 4wyd (A) 8 437 99.99 0 1 2.16318 -0.92

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3BV0:
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  • 3LV2:
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  • 3TFT:
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  • 3TFU:
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  • 4CXQ:
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  • 4CXR:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
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  • 4MQN:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
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  • 4MQO:
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  • 4MQP:
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  • 4MQQ:
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  • 4MQR:
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  • 4W1V:
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  • 4W1W:
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  • 4W1X:
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  • 4WYA:
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  • 4WYC:
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  • 4WYD:
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  • 4WYE:
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  • 4WYF:
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  • 4WYG:
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  • 4XEW:
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  • 4XJL:
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  • 4XJM:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
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  • 4XJO:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4XJP:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 5KGS:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 5KGT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
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  • 5TE2:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. murphy
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase. hasan
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_128068)

Species Accession Gene Product
Arabidopsis thaliana AT3G22200   gamma-aminobutyrate transaminase POP2
Candida albicans CaO19.11051   second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Candida albicans CaO19.3567   second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Candida albicans CaO19.10122   adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria
Candida albicans CaO19.2591   adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria
Dictyostelium discoideum DDB_G0290721   aminotransferase class-III
Escherichia coli b0774   7,8-diaminopelargonic acid synthase, PLP-dependent
Mycobacterium leprae ML1216   PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA
Mycobacterium tuberculosis Rv3329   Probable aminotransferase
Mycobacterium tuberculosis Rv1568   Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA
Mycobacterium ulcerans MUL_1559   adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Mycobacterium ulcerans MUL_2791   hypothetical protein
Oryza sativa 4328053   Os02g0112900
Oryza sativa 4336982   Os04g0614500
Oryza sativa 4344928   Os08g0205900
Oryza sativa 4336983   Os04g0614600
Saccharomyces cerevisiae YNR058W   adenosylmethionine-8-amino-7-oxononanoate transaminase
Schmidtea mediterranea mk4.074688.01  
Schmidtea mediterranea mk4.027108.13  
Trichomonas vaginalis TVAG_258770   acetylornithine aminotransferase, putative

Essentiality

Rv1568 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu1596 this record Mycobacterium tuberculosis non-essential nmpdr
b0774 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 0   527344   568456  
Annotator: crowther@u.washington.edu. Comment: 2007-12-21. References: 16984394

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.7

Known modulators for this target

300 chemical compounds are associated with this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0504 0.3871 0.492
0.1214 1 1
0.0654 0.5611 1
0.0184 0.2631 1
0.0161 0.3115 1
0.0184 0.7001 1
0.1072 0.5649 1
0.0312 0.7586 1
0.0954 0.2681 0.9647
0.0627 1 1
0.0156 0.4789 0.4789
0.0632 0.2843 0.526
0.0147 0.4885 1
0.0184 0.6095 1
0.0456 0.9526 1
0.1054 1 1
0.0482 1 1
0.0307 1 1
0.0633 0.2858 0.6465
0.016 0.2879 0.6588
0.0132 0.5128 0.7281
0.154 1 1
0.015 0.3303 1
0.0153 0.4169 0.6009
0.0184 0.3653 0.6518
0.0155 0.4041 0.6521
0.0311 1 1
0.0324 0.2519 1
0.0184 0.4689 1
0.0636 0.2505 0.919
0.154 1 1
0.0303 0.2942 1
0.0323 1 1
0.015 0.3664 1
0.1094 0.2536 0.9142
0.0327 0.386 1
0.0159 0.3607 0.6809
0.0155 0.2612 0.3022
0.0332 0.2664 0.2641
0.1197 1 1
0.0184 0.3899 0.5
0.0158 0.5478 1
0.0184 0.4221 1
0.0472 0.8426 1
0.0147 0.699 0.5
0.035 0.3521 0.6438
0.0184 0.3653 1
0.0184 0.8777 1
0.0242 0.2616 0.8893
0.0173 0.6705 0.7074
0.1584 1 0.5
0.0151 0.3648 0.5031
0.0184 0.5 0.5
0.0337 0.2641 1
0.033 0.4551 1
0.041 0.276 1
0.0184 0.5 0.5
0.048 0.2871 1
0.0147 0.253 0.4979
0.0356 1 1
0.0157 0.3946 1
0.0502 1 1
0.0147 0.4768 0.9486
0.0976 0.2788 1
0.0681 0.2832 0.677
0.1382 0.8453 1
0.0184 1 1
0.1398 1 1
0.0149 0.3575 1
0.0184 1 1
0.0184 0.4463 0.8059
0.0162 0.3392 0.325
0.015 0.2725 1
0.0466 0.3265 1
0.0355 0.4185 1
0.0342 1 1
0.0513 0.3089 1
0.0171 0.3954 0.5935
0.0301 0.5892 1
0.0302 0.4164 0.4172
0.0158 1 1
0.1337 0.8122 1
0.0937 0.323 0.771
0.031 0.6203 1
0.1987 1 1
0.0485 1 1
0.0328 0.3246 1
0.0151 0.2721 0.6738
0.1689 0.9538 1
0.0156 1 0.5
0.0304 0.2884 1
0.1559 0.895 1
0.0634 0.8826 0.882
0.0819 0.5 0.5
0.016 0.3368 1
0.0184 0.4522 0.9368
0.0147 0.3942 0.5598
0.0153 0.4885 1
0.0163 0.8839 1
0.0184 0.516 1
0.03 1 0.5
0.0306 1 1
0.0513 0.3089 1
0.0149 1 0.5
0.0507 1 1
0.03 1 0.5
0.1283 0.2531 1
0.182 1 1
0.0177 0.8024 1
0.0624 0.2847 0.6449
0.0624 0.2733 1
0.0352 0.37 0.6505
0.0184 1 1
0.0612 0.3488 1
0.0616 0.4013 1
0.0975 0.995 1
0.03 0.2683 1
0.0297 1 1
0.1234 0.9794 1
0.0328 0.2702 0.2679
0.0618 0.2691 1
0.0152 0.4377 1
0.0149 0.325 1
0.0162 0.6407 0.6284
0.0791 0.2791 0.7814
0.0184 1 1
0.0171 0.5855 0.5855
0.0176 0.3277 1
0.0665 1 1
0.0184 0.8652 1
0.0515 0.3001 0.9974
0.0154 0.7043 1
0.154 1 1
0.0362 0.3763 1
0.1173 1 1
0.0147 0.2778 1
0.0148 0.2665 0.5
0.0626 0.2712 0.8944
0.124 0.6814 1
0.0184 1 1
0.0628 0.2511 0.3593
0.0146 0.2601 1
0.0318 0.4167 1
0.0317 0.2554 0.2494
0.0308 0.9106 1
0.0184 1 0.5
0.0184 0.2678 1
0.0531 0.6305 0.9922
0.0155 0.3649 1
0.0319 0.2719 1
0.0184 0.3216 0.3742
0.0161 0.4415 1
0.0154 0.6081 0.5979
0.0149 0.3771 1
0.0159 0.339 1
0.0327 1 1
0.0184 0.5342 1
0.0333 0.892 1
0.0151 1 1
0.062 0.2846 1
0.0681 0.2832 0.677
0.0152 0.9529 0.5
0.0346 0.3365 1
0.0152 0.6247 1
0.2037 0.994 1
0.0295 0.5892 1
0.0309 0.4136 1
0.0529 0.3326 1
0.1549 0.8807 1
0.1559 0.895 1
0.0152 0.2639 0.2929
0.0154 0.2711 0.5
0.0157 0.4324 0.6498
0.0149 0.2592 0.9226
0.154 1 1
0.0974 0.2757 0.9733
0.0151 0.2655 0.2945
0.0184 0.734 1
0.1246 0.783 1
0.0044 0.3083 1
0.0599 0.275 0.6403
0.0473 0.2816 0.5776
0.0482 1 1
0.0758 1 1
0.0969 0.3446 1
0.0309 0.4136 1
0.0322 1 1
0.0674 0.2661 0.9392
0.0169 0.3147 0.3141
0.0155 0.3673 1
0.0486 0.4878 1
0.0148 0.3413 1
0.0485 0.3288 1
0.0161 0.3422 1
0.0927 0.3124 0.9309
0.0182 1 1
0.0309 0.582 1
0.0159 0.6112 0.5979
0.0256 0.2583 1
0.0628 0.3121 1
0.0163 0.3248 1
0.0164 1 1
0.0309 0.4136 1
0.0496 0.4952 1
0.0447 0.4394 1
0.1096 0.2523 0.9081
0.2151 0.9582 1
0.033 1 1
0.0151 0.2995 0.6257
0.0164 1 1
0.06 0.4182 1
0.1564 1 1
0.0184 1 0.5
0.1904 1 1
0.0184 0.3899 0.5
0.0113 0.3653 0.5427
0.0455 1 1
0.0313 0.6002 1
0.016 0.2896 1
0.031 1 1
0.034 0.4216 1
0.0313 0.9981 1
0.1166 1 1
0.0184 0.621 1
0.0298 0.366 1
0.0184 0.5 0.5
0.0352 0.37 0.6505
0.0622 0.3517 0.8776
0.1083 1 1
0.0184 0.4675 1
0.1423 1 0.5
0.0956 1 1
0.0159 0.3569 0.6876
0.0446 1 1
0.0147 0.5666 0.5
0.015 0.8075 0.5
0.0502 0.5443 0.9798
0.0178 1 1
0.0184 0.639 1
0.1188 1 1
0.0184 0.5 0.5
0.0317 0.929 1
0.0151 0.6767 0.5
0.0298 0.603 1
0.0316 0.4456 0.4435
0.0155 0.3177 0.3161
0.0337 0.4762 0.4716
0.0614 0.273 1
0.015 0.5437 0.5
0.0462 0.2969 1
0.1096 0.2535 0.9112
0.0184 0.6038 1
0.0306 0.2694 1
0.0318 0.4167 1
0.0639 1 1
0.0147 0.2506 1
0.1058 0.2921 1
0.1838 0.9314 1
0.0148 0.5914 1
0.061 0.478 1
0.0463 1 1
0.016 0.2896 1
0.0152 0.2583 0.5
0.0158 0.5975 1
0.0351 1 1
0.1137 1 1
0.1765 1 1
0.0609 0.4218 1
0.0154 0.411 0.8774
0.0149 0.3795 1
0.0599 0.275 0.6403
0.0178 0.9045 0.9958
0.0317 1 1
0.0167 0.4189 0.8236
0.1933 1 1
0.0819 0.5 0.5
0.0155 0.8915 1
0.0299 0.2668 1
0.0184 1 1
0.0307 0.6039 1
0.0151 0.5499 0.5432
0.0769 1 1
0.0153 0.8865 1
0.0148 0.5012 1
0.0168 0.3038 1
0.1553 0.9183 1
0.0635 0.2967 1
0.0165 0.2595 0.9816
0.0319 0.2719 1
0.0149 0.4706 0.5
0.034 1 1
0.035 0.3734 1
0.0165 0.3144 0.3091
0.1331 1 1
0.0338 0.8215 1
0.0462 1 1
0.0158 0.8809 1
0.0149 0.2895 0.5
0.0184 0.5909 1
0.0184 0.2695 0.2639
0.0324 0.3219 0.4456
0.0447 0.4394 1
0.015 0.3354 0.6603
0.0309 0.6009 1
0.0184 0.5 0.5
0.0184 1 1
0.0184 0.7582 0.742
0.0812 0.3817 1
0.1222 0.9544 1
0.0306 0.3566 1
0.0151 0.4266 0.5975
0.0302 0.4115 0.4172
0.0328 1 1
0.2213 1 1
0.0484 0.4096 1
0.1818 1 1
0.0153 0.7455 0.5
0.0491 0.5044 0.9328
0.2041 0.8844 1
0.1822 1 1
0.0504 0.3871 0.492
0.1709 1 0.5
0.045 1 1
0.016 0.4152 1
0.0154 0.3825 1
0.0158 0.6431 1
0.0184 0.4689 1
0.0152 0.3286 1
0.017 1 1
0.1124 1 1
0.0184 0.5979 0.5979
0.0471 0.3705 0.9629
0.0515 0.3001 0.9974
0.0529 0.3326 1
0.0184 0.3538 1
0.0297 0.5015 1
0.0304 0.8588 1
0.0184 0.8862 1
0.0927 0.4327 0.7661
0.0152 1 1
0.0308 0.3811 0.5812
0.0164 0.3383 1
0.1398 1 1
0.0184 0.8791 0.5
0.0184 0.4675 1
0.0184 0.29 0.5
0.0164 0.4529 0.626
0.0968 0.2768 0.9679
0.0309 0.4136 1
0.0152 0.2835 1
0.0147 0.3122 0.299
0.0161 0.4753 0.6681
0.0184 0.5 0.5
0.016 0.5835 1
0.0148 0.3061 0.5
0.0146 0.3393 0.6214
0.0328 0.3429 1
0.0148 0.406 0.5447
0.0184 1 1
0.0184 0.4927 1
0.0294 0.5128 1
0.0626 0.2712 0.8944
0.0319 1 1
0.0162 0.3392 0.325
0.0504 0.3871 0.492
0.0167 0.3458 1
0.0482 1 1
0.0184 0.5 0.5
0.0529 0.3326 1
0.0482 1 1
0.0175 0.4045 1
0.0143 0.3413 0.4264
0.0184 1 1
0.1072 0.5649 1
0.0475 0.5079 0.5044
0.0184 0.2631 1
0.0337 0.2642 1
0.0494 1 1
0.0309 0.2578 0.2515
0.051 0.5432 1
0.0178 0.3146 1
0.0348 0.3391 0.3339
0.0151 0.5001 0.5
0.0184 0.8591 0.5
0.0447 1 1
0.0153 1 1
0.0324 0.9706 1
0.045 0.5485 1
0.0164 0.3259 1
0.1246 0.783 1
0.064 0.2531 1
0.0154 0.3101 0.3019
0.0485 0.3288 1
0.0152 0.4057 0.5426
0.0184 0.7617 0.7874
0.138 0.6841 1
0.0334 0.5149 1
0.015 0.2786 1
0.0184 0.6109 1
0.0151 0.4469 1
0.0515 0.3001 0.9974
0.0106 0.6983 1
0.0161 0.3102 1
0.03 1 1
0.0599 0.275 0.6403
0.0316 0.6039 1
0.0172 1 1
0.0181 0.4415 1
0.0333 0.3847 1
0.0152 0.5463 1
0.0315 0.589 1
0.016 0.7684 1
0.0319 0.3481 1
0.0308 0.6047 1
0.0184 1 1
0.0599 0.275 0.6403
0.0343 0.4675 1
0.0176 1 1
0.1607 1 1
0.0463 0.4657 1
0.0688 0.2753 1
0.0148 0.314 1
0.0184 0.5 0.5
0.015 0.2813 1
0.0149 0.3833 1
0.0334 0.6006 1
0.0184 0.2613 0.5
0.0626 0.2712 0.8944
0.09 1 1
0.0769 1 1
0.016 0.2896 1
0.0156 0.6673 0.6445
0.1382 0.8453 1
0.048 0.2753 0.6219
0.0473 0.2816 0.5776
0.0184 0.6558 0.8087
0.0184 0.6349 0.6257
0.0175 0.8952 1
0.0319 1 1
0.1337 0.8122 1
0.0184 0.7455 0.7455
0.0148 0.2661 0.5
0.0184 1 1
0.0184 0.6303 0.6257
0.0455 0.283 0.2785
0.0147 0.7908 0.5
0.0184 1 1
0.0184 0.5 0.5
0.0184 0.4556 1
0.0798 1 1
0.0184 0.4675 1
0.0184 0.4689 1
0.0331 1 1
0.0184 0.634 1
0.1904 1 1
0.0184 1 0.5
0.0184 0.8821 1
0.0501 0.508 0.952
0.0446 0.6051 1
0.0473 0.2816 0.5776
0.0152 0.3189 0.3189
0.0149 0.3391 1
0.0744 0.7574 1
0.0486 0.675 1
0.0504 0.3871 0.492
0.1767 1 1
0.0304 0.5762 0.5
0.0625 0.3108 0.8779
0.048 0.2735 0.9521
0.0454 1 1
0.0184 0.8837 1
0.182 0.674 1
0.0148 0.5353 0.5235
0.0309 0.4136 1
0.0171 0.2573 1
0.0163 1 1
0.0306 0.3075 1
0.0629 0.2507 1
0.0147 1 0.5
0.0148 0.5824 0.5
0.0161 0.2828 0.5959
0.0184 1 0.5
0.0184 0.4675 1
0.0177 0.4048 0.5
0.1605 1 1
0.0184 0.6371 1
0.0315 1 1
0.032 0.5 0.5
0.0151 0.2674 0.6265
0.0184 1 1
0.0172 0.4865 1
0.0148 0.8837 1
0.0184 0.4888 1
0.0481 0.5705 1
0.0184 0.4689 1
0.0329 0.3619 0.3906
0.0149 0.3771 1
0.0159 0.7188 0.7075
0.0148 0.27 0.5
0.048 0.2735 0.9521
0.138 0.6841 1
0.0154 0.2895 1
0.0158 0.3373 0.3241
0.0184 1 0.5
0.0309 0.9248 1
0.0184 1 1
0.0149 0.2895 0.3082
0.0332 0.3057 1
0.0184 1 1
0.0962 0.5417 1
0.0316 0.3644 1
0.0148 0.3061 0.5
0.0184 0.4146 0.5
0.0168 1 1
0.0471 0.3705 0.9629
0.0156 0.3565 0.6674
0.0165 0.5993 0.5993
0.0156 0.4152 1
0.0981 0.2772 0.9992
0.0184 1 1
0.0959 0.2681 0.9652
0.0148 0.2951 0.2951
0.0362 0.5852 1
0.0442 0.2806 1
0.046 0.4973 1
0.0482 0.5197 1
0.0149 1 1
0.0295 0.5892 1
0.0314 0.3598 0.5
0.0184 0.5 0.5
0.03 0.2683 1
0.154 1 1
0.0147 0.2611 0.2466
0.0184 0.4247 1
0.0298 0.3859 1
0.154 1 1
0.0476 0.497 0.9624
0.0148 0.3428 0.6737
0.0184 0.3653 1
0.129 0.2535 1
0.0333 0.331 1
0.0316 0.5965 1
0.1933 1 1
0.0184 0.5 0.5
0.1058 0.2921 1
0.03 1 0.5
0.0326 0.6697 1
0.0153 0.6686 0.6443
0.062 0.3102 0.8975
0.0328 0.4498 1
0.0304 0.3225 0.3199
0.0148 0.5353 0.5235
0.0506 0.303 1
0.0326 0.6566 1
0.0332 1 1
0.0522 1 1
0.016 0.4098 0.5
0.1389 1 1
0.0154 0.3159 1
0.0161 0.7065 1
0.0295 0.5931 1
0.0529 0.3326 1
0.0503 0.2897 0.9898
0.046 1 1
0.0329 0.3679 1
0.0303 0.283 1
0.0312 0.3688 1
0.1398 1 1
0.0184 0.4857 1
0.0322 0.6232 1
0.0517 0.5358 1
0.0299 0.5568 0.5
0.0819 0.5 0.5
0.1699 1 0.5
0.0184 1 1
0.0148 0.3365 1
0.1398 1 1
0.0184 0.4721 0.4639
0.1779 1 1
0.0471 0.3807 1
0.0501 0.2892 1
0.0455 0.5637 1
0.0154 0.2711 0.5
0.0152 0.6247 1
0.0303 0.6359 1
0.1245 1 1
0.016 0.7077 0.7437
0.0184 0.5 0.5
0.0513 0.3089 1
0.0177 0.4847 1
0.1398 1 1
0.0173 0.7854 1
0.0328 1 1
0.0184 0.3774 1
0.0327 0.3644 1
0.0184 1 0.5
0.0158 1 1
0.0324 0.2519 1
0.0158 0.8674 1
0.0169 0.4152 1
0.0503 0.2897 0.9898
0.0324 0.2519 1
0.0165 0.3753 1
0.031 0.5559 0.5
0.0184 0.5 0.5
0.1818 1 1
0.0297 0.4774 1
0.1696 0.9771 1
0.0167 0.288 0.5661
0.0473 0.2816 0.5776
0.0309 0.4136 1
0.0304 0.6047 1
0.0456 0.9526 1
0.0473 0.2816 0.5776
0.1818 1 1
0.0924 0.3121 0.9275
0.0153 0.2883 1
0.0184 0.4801 1
0.0302 0.3122 0.311
0.0155 0.4837 1
0.015 0.9614 1
0.0054 0.3811 0.5
0.0454 1 1
0.0326 0.4283 1
0.1698 0.9857 1
0.0184 0.6196 1
0.0161 0.6484 1
0.0312 0.6232 1
0.0975 0.9952 1
0.0148 0.432 0.6155
0.0161 0.3254 0.3158
0.0158 0.2909 0.6819
0.0317 0.5578 1
0.0807 1 1
0.0161 0.5912 0.5
0.1731 0.9983 1
0.1793 1 1
0.0321 0.2644 0.2577
0.0155 1 0.5
0.0137 0.3628 1
0.0303 0.3163 1
0.0149 0.2592 0.9226
0.0155 0.2963 0.6351
0.0299 0.4224 0.6293
0.0626 0.2724 1
0.0184 0.5901 0.5979
0.0312 0.6232 1
0.0609 0.4218 1
0.0148 0.2853 1
0.0602 0.4503 1
0.0184 1 1
0.0313 0.6046 1
0.0309 0.4136 1
0.0319 0.3816 0.5898
0.0603 0.8206 1
0.0155 0.7891 1
0.0309 0.4136 1
0.0184 0.4689 1
0.0159 0.3982 0.4089
0.033 0.4527 1
0.0628 0.3121 1
0.0317 1 1
0.0304 0.3172 1
0.0157 0.4379 0.6131
0.0329 0.3619 0.3906
0.0184 0.4675 1
0.0154 0.5798 1
0.0906 1 1
0.0299 1 1
0.0153 0.6659 0.5
0.0713 0.4228 1
0.0184 0.5505 0.7439
0.0184 1 0.5
0.1592 0.9269 1
0.0151 0.4497 0.7007
0.0151 1 1
0.0184 1 0.5
0.0311 0.2567 0.2514
0.1814 1 1
0.0152 0.8217 0.5
0.0151 0.4315 1
0.0147 0.6022 1
0.0184 0.7617 0.7874
0.0159 0.5165 1
0.046 0.4646 1
0.0131 0.8591 0.5
0.0256 0.2583 1
0.0314 0.6196 1
0.0306 0.2732 1
0.0325 1 0.5
0.0152 0.5 0.6481
0.016 0.2561 0.5
0.0793 0.951 1
0.1778 1 1
0.0306 0.3666 0.5558
0.017 0.7284 0.7231
0.0455 0.9201 1
0.0446 1 1
0.1385 0.9295 1
0.0484 0.4096 1
0.036 0.3744 0.5
0.0267 0.3223 1
0.0294 0.3191 1
0.0149 0.3956 0.6357
0.154 1 1
0.1853 1 1
0.0151 0.3792 1
0.0333 0.4324 1
0.0149 0.4032 0.5442
0.0184 1 1
0.0308 0.3054 0.3901
0.0299 0.2986 1
0.0494 0.2756 0.7605
0.1072 0.5649 1
0.061 0.4825 1
0.0168 0.3108 0.9694
0.0184 0.6319 1
0.0158 0.9224 0.9216
0.066 0.7719 1
0.0354 1 0.5
0.0303 0.3462 1
0.0328 1 1
0.0156 0.9892 1
0.1532 0.8582 1
0.0161 0.3256 1
0.0933 0.2537 1
0.016 0.3017 0.3017
0.0529 0.3326 1
0.0306 0.5817 1
0.062 0.2846 1
0.0152 0.2696 0.5
0.0304 0.3172 1
0.0503 0.2897 0.9898
0.0169 0.4651 0.7201
0.0184 1 1
0.0184 0.4028 1
0.033 0.4137 1
0.0184 1 0.5
0.0165 1 1
0.0161 0.3726 1
0.0321 1 1
0.1788 1 1
0.0903 0.3134 0.9673
0.1382 0.8453 1
0.0152 0.7912 1
0.0408 0.4431 1
0.016 0.2896 1
0.0184 0.6359 0.6257
0.0156 0.3842 0.6378
0.0349 0.3701 0.6783
0.0452 1 1
0.0334 1 1
0.1818 1 1
0.0819 0.5 0.5
0.0184 0.5153 0.5
0.0317 0.362 1
0.0184 1 0.5
0.0347 1 1
0.024 0.6218 1
0.1086 0.5901 1
0.0163 0.3068 1
0.0494 0.2756 0.7605
0.0182 0.4629 1
0.013 0.3566 1
0.0309 0.4136 1
0.015 0.8075 0.5
0.0922 0.31 0.7661
0.0184 0.7001 1
0.0155 1 1
0.0302 0.3048 1
0.0336 1 1
0.0299 0.3005 1
0.0629 0.2507 1
0.0184 0.5505 0.7439
0.0184 1 0.5
0.0624 0.283 0.6428
0.0152 0.3253 0.6476
0.0184 1 1
0.0159 0.339 1
0.0157 1 1
0.0161 0.441 1
0.0149 0.4884 1
0.0606 0.4887 1
0.0184 0.5923 0.5
0.0148 0.3164 0.3038
0.0184 0.4184 1
0.0158 0.4918 0.5
0.0482 1 1
0.0184 0.5 0.5
0.1171 1 1
0.1584 1 0.5
0.0456 0.9526 1
0.1798 1 1
0.0148 0.3546 0
0.0297 1 1
0.0166 1 1
0.0154 0.8883 1
0.0456 0.9526 1
0.1228 1 1
0.0148 0.2853 1
0.0184 1 1
0.0154 0.4081 0.877
0.0928 0.2558 0.7732
0.0445 1 1
0.0163 0.3055 0.6236
0.1683 1 1
0.0169 0.3491 1
0.0503 0.2897 0.9898
0.1813 1 1
0.0184 0.4221 0.6432
0.0455 1 1
0.0184 0.4268 0.8191
0.024 0.4823 0.4643
0.0184 1 1
0.0158 1 1
0.0163 0.3271 0.7033
0.0304 0.5762 0.5
0.0178 0.301 1
0.0147 0.2641 0.2578
0.182 0.674 1
0.052 0.539 0.9921
0.0171 0.4531 0.5
0.0349 1 1
0.1097 0.2546 0.9181
0.0161 0.275 0.5
0.0323 1 1
0.0461 0.4927 0.9624
0.0959 0.2681 0.9652
0.0184 1 1
0.112 1 1
0.0148 0.3596 1
0.0442 0.2806 1
0.0177 1 0.5
0.0303 0.2942 1
0.0309 0.4136 1

Assayability

Assay information

  • ChEMBL
  • PubChem BioAssay. Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)

Reagent availability

  • Reagent:
  • Target Type Source Notes
    Rv1568 cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 1 )

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Rv1568 (Mycobacterium tuberculosis), Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA
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