pI: 5.3581 |
Length (AA): 365 |
MW (Da): 39743 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 348 | 2amx (A) | 37 | 371 | 24.00 | 0 | 1 | 1.25432 | -0.55 |
14 | 354 | 3iar (A) | 10 | 349 | 29.00 | 0 | 1 | 1.28575 | -0.69 |
145 | 251 | 3fiw (A) | 47 | 175 | 32.00 | 0.37 | 0.05 | 0.252651 | 1.28 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127245)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G04880 | adenosine deaminase-like protein |
Babesia bovis | BBOV_I001470 | adenosine deaminase, putative |
Brugia malayi | Bm1_18590 | Adenosine/AMP deaminase family protein |
Candida albicans | CaO19.9791 | similar to S. cerevisiae AAH1 (YNL141W) adenine aminohydrolase |
Candida albicans | CaO19.2251 | similar to S. cerevisiae AAH1 (YNL141W) adenine aminohydrolase |
Caenorhabditis elegans | CELE_C06G3.5 | Protein C06G3.5, isoform B |
Caenorhabditis elegans | CELE_C44B7.12 | Protein C44B7.12 |
Dictyostelium discoideum | DDB_G0287371 | adenosine deaminase |
Drosophila melanogaster | Dmel_CG11994 | Adenosine deaminase |
Escherichia coli | b1623 | adenosine deaminase |
Echinococcus granulosus | EgrG_000536400 | adenosine deaminase |
Entamoeba histolytica | EHI_014320 | adenosine deaminase, putative |
Entamoeba histolytica | EHI_005040 | adenosine deaminase, putative |
Echinococcus multilocularis | EmuJ_000536400 | adenosine deaminase |
Homo sapiens | ENSG00000196839 | adenosine deaminase |
Homo sapiens | ENSG00000168803 | adenosine deaminase-like |
Leishmania braziliensis | LbrM.34.2090 | adenine aminohydrolase |
Leishmania donovani | LdBPK_352200.1 | adenine aminohydrolase |
Leishmania infantum | LinJ.35.2200 | adenine aminohydrolase |
Leishmania major | LmjF.35.2160 | adenine aminohydrolase |
Leishmania mexicana | LmxM.34.2160 | adenine aminohydrolase |
Loa Loa (eye worm) | LOAG_13491 | hypothetical protein |
Loa Loa (eye worm) | LOAG_09631 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15299 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12299 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15552 | hypothetical protein |
Mycobacterium leprae | ML0700 | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) |
Mus musculus | ENSMUSG00000017697 | adenosine deaminase |
Mus musculus | ENSMUSG00000027259 | adenosine deaminase-like |
Mycobacterium tuberculosis | Rv3313c | Probable adenosine deaminase Add (adenosine aminohydrolase) |
Mycobacterium ulcerans | MUL_1364 | adenosine deaminase |
Neospora caninum | NCLIV_052400 | adenosine/AMP deaminase domain containing protein, putative |
Neospora caninum | NCLIV_019950 | Adenosine deaminase (EC 3.5.4.4), related |
Oryza sativa | 4344179 | Os07g0661000 |
Onchocerca volvulus | OVOC3922 | Adenosine deaminase homolog |
Plasmodium berghei | PBANKA_0513600 | adenosine deaminase, putative |
Plasmodium falciparum | PF3D7_1029600 | adenosine deaminase |
Plasmodium knowlesi | PKNH_0614300 | adenosine deaminase, putative |
Plasmodium vivax | PVX_111245 | adenosine deaminase, putative |
Plasmodium yoelii | PY02076 | adenosine deaminase |
Saccharomyces cerevisiae | YNL141W | adenine deaminase |
Schistosoma japonicum | Sjp_0056550 | ko:K01488 adenosine deaminase [EC3.5.4.4], putative |
Schistosoma japonicum | Sjp_0051070 | ko:K01488 adenosine deaminase [EC3.5.4.4], putative |
Schistosoma mansoni | Smp_140430 | adenosine deaminase-related |
Schistosoma mansoni | Smp_035700 | adenosine deaminase |
Schmidtea mediterranea | mk4.000517.09 | |
Schmidtea mediterranea | mk4.001281.03 | |
Schmidtea mediterranea | mk4.000517.08 | |
Schmidtea mediterranea | mk4.003471.00 | |
Schmidtea mediterranea | mk4.001179.00 | Putative adenosine deaminase |
Toxoplasma gondii | TGME49_205720 | Adenosine/AMP deaminase domain-containing protein |
Toxoplasma gondii | TGME49_215480 | Adenosine/AMP deaminase domain-containing protein |
Treponema pallidum | TP0045 | adenosine deaminase |
Trichomonas vaginalis | TVAG_416510 | adenosine deaminase, putative |
Trichomonas vaginalis | TVAG_430670 | adenosine deaminase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b1623 | Escherichia coli | non-essential | goodall |
CELE_C06G3.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_0513600 | Plasmodium berghei | Dispensable | plasmo |
TGME49_215480 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_205720 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | adenosine deaminase | Compounds | References |
Plasmodium falciparum | adenosine deaminase | Compounds | References |
Bos taurus | Adenosine deaminase | Compounds | References |
Mus musculus | adenosine deaminase | Compounds | References |