pI: 6.657 |
Length (AA): 764 |
MW (Da): 80534 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 10
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 160 | 3b9w (A) | 199 | 341 | 31.00 | 0.055 | 0.47 | 0.346406 | 0.96 |
23 | 512 | 5da0 (A) | 14 | 476 | 24.00 | 0 | 1 | 0.835961 | 0.53 |
25 | 454 | 5da0 (A) | 16 | 409 | 30.00 | 0 | 0.96 | 0.757427 | 0.8 |
439 | 512 | 3oiz (A) | 399 | 473 | 16.00 | 0 | 0.61 | 0.405459 | -1.22 |
515 | 746 | 2a5v (A) | 0 | 201 | 26.00 | 0 | 1 | 0.418265 | 0.15 |
545 | 760 | 5swc (A) | 0 | 220 | 25.00 | 0.00000000039 | 1 | 0.577623 | -0.28 |
547 | 762 | 3ucj (A) | 6 | 210 | 28.00 | 0 | 1 | 0.565323 | -0.23 |
571 | 760 | 5swc (A) | 26 | 220 | 33.00 | 0 | 1 | 0.536291 | -0.19 |
616 | 684 | 3n2t (A) | 33 | 107 | 36.00 | 0.27 | 0.39 | 0.298914 | 0.99 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129533)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_II006030 | sulfate transporter, putative |
Chlamydia trachomatis | CT_856 | sulfate transporter |
Escherichia coli | b1206 | C4-dicarboxylic acid transporter |
Mycobacterium leprae | ML2279c | Probable transmembrane transport protein |
Mycobacterium tuberculosis | Rv1707 | Probable conserved transmembrane protein |
Mycobacterium tuberculosis | Rv3273 | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) |
Mycobacterium ulcerans | MUL_5080 | transmembrane carbonic anhydrase, SulP |
Mycobacterium ulcerans | MUL_0666 | transmembrane carbonic anhydrase, SulP |
Mycobacterium ulcerans | MUL_0321 | integral membrane transporter |
Neospora caninum | NCLIV_019650 | hypothetical protein |
Plasmodium berghei | PBANKA_1334400 | inorganic anion antiporter, putative |
Plasmodium falciparum | PF3D7_1471200 | inorganic anion exchanger, inorganic anion antiporter |
Plasmodium knowlesi | PKNH_1209800 | sulfate transporter, putative |
Plasmodium vivax | PVX_116910 | sulfate transporter, putative |
Plasmodium yoelii | PY07224 | sulfate permease family protein |
Trypanosoma brucei gambiense | Tbg972.5.1740 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.5.1260 | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative |
Trypanosoma congolense | TcIL3000_5_1250 | hypothetical protein, conserved |
Trypanosoma congolense | TcIL3000_0_42680 | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative |
Trypanosoma cruzi | TcCLB.509601.110 | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative |
Trypanosoma cruzi | TcCLB.509767.110 | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative |
Toxoplasma gondii | TGME49_280500 | inorganic anion transporter, sulfate permease (SulP) family protein |
Theileria parva | TP02_0554 | sulfate transporter, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.1260 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.1260 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.1260 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.5.1260 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1206 | Escherichia coli | non-essential | goodall |
TGME49_280500 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Methanobacterium thermoautotrophicum | Carbonic anhydrase | 176 aa | 27.5% | 167 aa | Compounds | References |
Anopheles gambiae | AGAP002992-PA | 255 aa | 31.9% | 226 aa | Compounds | References |
Candida glabrata CBS 138 | Carbonic anhydrase | 219 aa | 25.6% | 199 aa | Compounds | References |
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) | Carbonic anhydrase 1 | 221 aa | 27.9% | 197 aa | Compounds | References |