pI: 7.7128 |
Length (AA): 155 |
MW (Da): 17505 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127571)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G44620 | protein-tyrosine phosphatase |
Brugia malayi | Bm1_37740 | Low molecular weight phosphotyrosine protein phosphatase containing protein |
Candida albicans | CaO19.5104 | C terminus of potential Low molecular weight phosphoTyrosine Phosphatase |
Candida albicans | CaO19.12570 | 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene |
Caenorhabditis elegans | CELE_Y94H6A.7 | Protein Y94H6A.7 |
Dictyostelium discoideum | DDB_G0267484 | acid phosphatase 1 |
Drosophila melanogaster | Dmel_CG33748 | CG33748 gene product from transcript CG33748-RA |
Drosophila melanogaster | Dmel_CG33747 | CG33747 gene product from transcript CG33747-RC |
Drosophila melanogaster | Dmel_CG31469 | CG31469 gene product from transcript CG31469-RA |
Escherichia coli | b2061 | colanic acid production protein-tyrosine-phosphatase |
Escherichia coli | b0982 | Protein-tyrosine-phosphatase, role in O-antigen capsule formation |
Entamoeba histolytica | EHI_103800 | protein tyrosine phosphatase, putative |
Entamoeba histolytica | EHI_153650 | protein tyrosine phosphatase, putative |
Giardia lamblia | GL50803_14456 | Low molecular weight protein-tyrosine-phosphatase |
Homo sapiens | ENSG00000143727 | acid phosphatase 1, soluble |
Loa Loa (eye worm) | LOAG_09034 | phosphotyrosine protein phosphatase |
Mus musculus | 102642088 | low molecular weight phosphotyrosine protein phosphatase-like |
Mus musculus | ENSMUSG00000044573 | acid phosphatase 1, soluble |
Mycobacterium tuberculosis | Rv2234 | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) |
Mycobacterium ulcerans | MUL_1319 | phosphotyrosine protein phosphatase PtpA |
Oryza sativa | 4346297 | Os08g0557400 |
Onchocerca volvulus | OVOC4340 |
|
Saccharomyces cerevisiae | YPR073C | Ltp1p |
Trichomonas vaginalis | TVAG_388870 | low molecular weight protein-tyrosine-phosphatase, putative |
Trichomonas vaginalis | TVAG_458720 | low molecular weight protein-tyrosine-phosphatase, putative |
Trichomonas vaginalis | TVAG_350160 | low molecular weight protein tyrosine phosphatase, putative |
Trichomonas vaginalis | TVAG_174880 | low molecular weight protein tyrosine phosphatase, putative |
Trichomonas vaginalis | TVAG_376230 | low molecular weight protein tyrosine phosphatase, putative |
Trichomonas vaginalis | TVAG_005380 | low molecular weight protein-tyrosine-phosphatase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b0982 | Escherichia coli | non-essential | goodall |
b2061 | Escherichia coli | non-essential | goodall |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Saccharomyces cerevisiae | Ltp1p | Compounds | References |
Influenza A virus | Neuraminidase | Compounds | References |
Homo sapiens | acid phosphatase 1, soluble | Compounds | References |
Bos taurus | Low molecular weight phosphotyrosine protein phosphatase | Compounds | References |
Influenza A virus | Neuraminidase | Compounds | References |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | Compounds | References |